BLAST table : Fren_00150

DBUniProtKB
accessionDBalignmentEvalueScoreIdent.linkproductgeneorganismec
1
 Q54997_9ACTO
(Q54997)		 
[query] 1 - 160 (160)
[subject] 1 - 160 (160)
 2e-85 318   100% ActVI-ORFA homolog frnO Streptomyces roseofulvus
2
 F3Z6S7_9ACTO
(F3Z6S7)		 
[query] 10 - 104 (160)
[subject] 1 - 95 (152)
 5e-37 157   96% Putative ORFX STTU_0694 Streptomyces sp. Tu6071
3
 D9UBS1_STRPR
(D9UBS1)		 
[query] 23 - 156 (160)
[subject] 16 - 149 (152)
 2e-35 152   55% Putative aromatase cpp13 Streptomyces pristinaespiralis
4
 B5HIV3_STRPR
(B5HIV3)		 
[query] 23 - 156 (160)
[subject] 16 - 149 (152)
 2e-35 152   55% Aromatic-ring-hydroxylating dioxygenase SSDG_05090 Streptomyces pristinaespiralis ATCC 25486
5
 Q2J5J0_FRASC
(Q2J5J0)		 
[query] 20 - 159 (160)
[subject] 5 - 144 (149)
 6e-34 147   52% Aromatic-ring-hydroxylating dioxygenase, beta subunit Francci3_4104 Frankia sp. (strain CcI3)
6
 B2D1N8_9ACTO
(B2D1N8)		 
[query] 91 - 160 (160)
[subject] 1 - 70 (70)
 7e-33 144   100% Frenolicin biosynthetic protein Streptomyces sp. WXC
7
 Q7WT16_9ACTO
(Q7WT16)		 Jump to Medem_00260 
[query] 25 - 156 (160)
[subject] 10 - 141 (146)
 7e-31 137   52% Putative uncharacterized protein med-ORF10 med-ORF10 Streptomyces sp. AM-7161
8
 D9UKN6_9ACTO
(D9UKN6)		 
[query] 98 - 160 (160)
[subject] 1 - 63 (63)
 2e-27 125   100% Aromatic-ring-hydroxylating dioxygenase SSLG_05752 Streptomyces sp. SPB78
9
 E3J3P6_FRASU
(E3J3P6)		 
[query] 22 - 156 (160)
[subject] 7 - 139 (142)
 2e-26 122   50% Aromatic-ring-hydroxylating dioxygenase beta subunit FraEuI1c_1316 Frankia sp. (strain EuI1c)
10
 Q9ZA28_STRVN
(Q9ZA28)		 Jump to Grana_00310 
[query] 25 - 157 (160)
[subject] 10 - 140 (142)
 3e-26 122   50% Gra-orf31 protein gra-orf31 Streptomyces violaceoruber
11
 D3U1V2_9BACT
(D3U1V2)		 
[query] 24 - 156 (160)
[subject] 17 - 147 (153)
 2e-25 119   50% ActVI-A like uncultured soil bacterium V167
12
 E3T4B5_9ACTO
(E3T4B5)		 
[query] 25 - 159 (160)
[subject] 10 - 142 (142)
 5e-25 117   46% Putative uncharacterized protein gra-orf31 Streptomyces vietnamensis
13
 D9W5A3_9ACTO
(D9W5A3)		 
[query] 25 - 159 (160)
[subject] 12 - 144 (144)
 1e-24 116   49% DNA-binding protein SSNG_07333 Streptomyces sp. C
14
 C7PWR4_CATAD
(C7PWR4)		 
[query] 18 - 156 (160)
[subject] 3 - 142 (154)
 2e-24 115   50% Aromatic-ring-hydroxylating dioxygenase beta subunit Caci_6494 Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
15
 Q54278_SACHI
(Q54278)		 
[query] 25 - 159 (160)
[subject] 10 - 142 (147)
 2e-23 112   50% DNA-binding protein Saccharopolyspora hirsuta
16
 D6EWC3_STRLI
(D6EWC3)		 
[query] 24 - 159 (160)
[subject] 9 - 144 (146)
 2e-21 105   42% Hydroxylacyl-CoA dehydrogenase SSPG_02618 Streptomyces lividans TK24
17
 Q53925_STRCO
(Q53925)		 Jump to Actino_00020 
[query] 24 - 159 (160)
[subject] 9 - 144 (146)
 3e-21 105   42% Hydroxylacyl-CoA dehydrogenase ORFA
SCO5071		 Streptomyces coelicolor
18
 B2HGM9_MYCMM
(B2HGM9)		 
[query] 8 - 156 (160)
[subject] 6 - 151 (153)
 2e-19 99.4 38% Putative uncharacterized protein MMAR_1563 Mycobacterium marinum (strain ATCC BAA-535 / M)
19
 Q70J90_STRGR
(Q70J90)		 Jump to Chro_00080 
[query] 25 - 156 (160)
[subject] 11 - 140 (142)
 8e-19 97.1 45% Cyclase cmmX Streptomyces griseus subsp. griseus
20
 C0JWC8_9ACTO
(C0JWC8)		 Jump to Polk_00330 
[query] 24 - 156 (160)
[subject] 14 - 144 (150)
 3e-18 95.1 46% PokC1 pokC1 Streptomyces diastatochromogenes
21
 Q935Z5_9ACTO
(Q935Z5)		 
[query] 23 - 156 (160)
[subject] 319 - 450 (452)
 2e-16 89   46% RdmK rdmK Streptomyces purpurascens
22
 Q53879_STRS5
(Q53879)		 Jump to Dauno_00030 
[query] 24 - 156 (160)
[subject] 21 - 148 (151)
 3e-16 88.6 46% Putative uncharacterized protein Streptomyces sp. (strain C5)
23
 B5G899_9ACTO
(B5G899)		 
[query] 23 - 156 (160)
[subject] 10 - 141 (144)
 5e-15 84.3 44% Hydroxylacyl-CoA dehydrogenase SSBG_00507 Streptomyces sp. SPB74
24
 D6MSU8_9ACTO
(D6MSU8)		 
[query] 40 - 156 (160)
[subject] 4 - 119 (123)
 1e-14 83.6 43% SsfY4 ssfY4 Streptomyces sp. SF2575
25
 Q3S8Q7_STRRM
(Q3S8Q7)		 Jump to Oxtet_00090 
[query] 24 - 156 (160)
[subject] 15 - 145 (150)
 1e-14 83.2 41% OxyI oxyI Streptomyces rimosus
26
 A1C176_9ACTO
(A1C176)		 Jump to Aran_00080 
[query] 23 - 156 (160)
[subject] 14 - 145 (151)
 7e-14 80.9 42% Aromatase Streptomyces echinatus
27
 B6SEE8_9ACTO
(B6SEE8)		 Jump to Alnu_00030 
[query] 22 - 156 (160)
[subject] 33 - 162 (172)
 1e-13 79.7 41% Aln2 aln2 Streptomyces sp. CM020
28
 Q9L4U3_9ACTO
(Q9L4U3)		 Jump to Acla_00240 
[query] 23 - 156 (160)
[subject] 10 - 141 (144)
 2e-13 79.3 41% AknV aknV Streptomyces galilaeus
29
 Q9ZAT9_STRPE
(Q9ZAT9)		 Jump to Adria_00050 
[query] 24 - 156 (160)
[subject] 64 - 191 (194)
 2e-13 79   42% Daunorubicin biosynthesis enzyme dpsH Streptomyces peucetius
30
 Q53670_STRAA
(Q53670)		 Jump to Mith_00130 
[query] 16 - 156 (160)
[subject] 9 - 147 (150)
 3e-13 79   39% Cyclase mtmX Streptomyces argillaceus
31
 D1A615_THECD
(D1A615)		 
[query] 22 - 157 (160)
[subject] 12 - 143 (146)
 5e-13 77.8 40% Putative uncharacterized protein Tcur_2764 Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
32
 E8W954_STRFA
(E8W954)		 
[query] 13 - 156 (160)
[subject] 5 - 148 (151)
 6e-13 77.8 40% Nuclear transport factor 2 Sfla_5320 Streptomyces flavogriseus (strain ATCC 33331 / DSM 40990 / IAF-45CD)
33
 E8SDG1_MICSL
(E8SDG1)		 
[query] 26 - 156 (160)
[subject] 15 - 143 (146)
 8e-13 77.4 42% Nuclear transport factor 2 ML5_4399 Micromonospora sp. (strain L5)
34
 D9T2B9_MICAI
(D9T2B9)		 
[query] 26 - 156 (160)
[subject] 15 - 143 (146)
 8e-13 77.4 42% Nuclear transport factor 2 Micau_4022 Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
35
 B8Y4H2_STRAU
(B8Y4H2)		 
[query] 22 - 159 (160)
[subject] 17 - 147 (147)
 2e-12 75.9 38% Putative cyclase sa16 Streptomyces aureofaciens
36
 B8Y4G8_STRAU
(B8Y4G8)		 
[query] 23 - 156 (160)
[subject] 19 - 151 (156)
 2e-12 75.9 39% Putative cyclase sa12 Streptomyces aureofaciens
37
 Q9RN65_STRNO
(Q9RN65)		 Jump to Nogl_00140 
[query] 4 - 156 (160)
[subject] 8 - 154 (155)
 4e-12 74.7 42% SnoO snoO Streptomyces nogalater
38
 Q2J5F3_FRASC
(Q2J5F3)		 
[query] 23 - 156 (160)
[subject] 14 - 145 (150)
 8e-12 73.9 39% Hydroxylacyl-CoA dehydrogenase Francci3_4141 Frankia sp. (strain CcI3)
39
 D7BZR6_STRBB
(D7BZR6)		 
[query] 16 - 156 (160)
[subject] 11 - 149 (152)
 1e-11 73.6 38% Hydroxylacyl-CoA dehydrogenase SBI_06851 Streptomyces bingchenggensis (strain BCW-1)
40
 B5G889_9ACTO
(B5G889)		 
[query] 24 - 156 (160)
[subject] 320 - 448 (450)
 4e-11 71.6 41% Granaticin polyketide synthase bifunctional cyclase/dehydratase SSBG_00497 Streptomyces sp. SPB74
41
 Q9L554_9ACTO
(Q9L554)		 Jump to Acla_00040 
[query] 24 - 156 (160)
[subject] 320 - 448 (450)
 4e-11 71.6 42% AknE1 aknE1 Streptomyces galilaeus
42
 Q4R0M5_STRCX
(Q4R0M5)		 Jump to Chart_00070 
[query] 25 - 156 (160)
[subject] 13 - 141 (145)
 1e-10 70.1 39% Putative uncharacterized protein chaN chaN Streptomyces chartreusis
43
 Q8VWB6_9ACTO
(Q8VWB6)		 
[query] 11 - 156 (160)
[subject] 311 - 448 (450)
 3e-10 68.6 40% AknE1 aknE1 Streptomyces galilaeus
44
 Q2PA04_9ACTO
(Q2PA04)		 Jump to Stref_00110 
[query] 25 - 156 (160)
[subject] 13 - 143 (146)
 2e-09 66.2 36% Cyclase stfX Streptomyces steffisburgensis
45
 Q9KHL2_9ACTO
(Q9KHL2)		 Jump to Enter_00030 
[query] 16 - 156 (160)
[subject] 20 - 158 (163)
 2e-08 62.8 31% EncG encG Streptomyces maritimus
46
 E1ARK7_STRAU
(E1ARK7)		 
[query] 25 - 146 (160)
[subject] 20 - 143 (156)
 1e-07 60.1 37% Putative cyclase sa45 Streptomyces aureofaciens
47
 Q2J5F8_FRASC
(Q2J5F8)		 
[query] 22 - 156 (160)
[subject] 13 - 148 (152)
 3e-06 55.5 34% Putative uncharacterized protein Francci3_4136 Frankia sp. (strain CcI3)
48
 D1XIB4_9ACTO
(D1XIB4)		 
[query] 28 - 156 (160)
[subject] 16 - 143 (151)
 9e-06 53.9 37% Aromatic-ring-hydroxylating dioxygenase beta subunit SACTEDRAFT_2424 Streptomyces sp. SA3_actE
49
 E4WAC6_RHOE1
(E4WAC6)		 
[query] 23 - 156 (160)
[subject] 13 - 144 (150)
 1e-05 53.5 35% Putative uncharacterized protein REQ_44380 Rhodococcus equi (strain 103S)
Corynebacterium equi
50
 E9SWH2_COREQ
(E9SWH2)		 
[query] 23 - 156 (160)
[subject] 12 - 143 (149)
 1e-05 53.5 35% Ring hydroxylating beta subunit superfamily protein HMPREF0724_10472 Rhodococcus equi ATCC 33707
51
 D7AZ66_NOCDD
(D7AZ66)		 
[query] 23 - 158 (160)
[subject] 3 - 136 (137)
 0.0005 48.1 33% Aromatic-ring-hydroxylating dioxygenase beta subunit Ndas_4660 Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei
52
 F8AWU0_9ACTO
(F8AWU0)		 
[query] 23 - 155 (160)
[subject] 9 - 132 (150)
 0.0006 47.8 32% Nuclear transport factor 2 FsymDg_2998 Frankia symbiont of Datisca glomerata
accessionDBalignmentEvalueScoreIdent.linkinformationpubmed
1
 Q54997_9ACTO
(Q54997)		 
[query] 1 - 160 (160)
[subject] 1 - 160 (160)
 2e-85 318   100%
Product
ActVI-ORFA homolog
Gene
frnO
Organism
Streptomyces roseofulvus
1uniprot[Pubmed] 8181754 [Medline] 94237486
Cloning, sequencing and deduced functions of a cluster of Streptomyces genes probably encoding biosynthesis of the polyketide antibiotic frenolicin.(Gene) [1994]
3
 D9UBS1_STRPR
(D9UBS1)		 
[query] 23 - 156 (160)
[subject] 16 - 149 (152)
 2e-35 152   55%
Product
Putative aromatase
Gene
cpp13
Organism
Streptomyces pristinaespiralis
1uniprot[Pubmed] 21342465
Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011]
5
 Q2J5J0_FRASC
(Q2J5J0)		 
[query] 20 - 159 (160)
[subject] 5 - 144 (149)
 6e-34 147   52%
Product
Aromatic-ring-hydroxylating dioxygenase, beta subunit
Gene
Francci3_4104
Organism
Frankia sp. (strain CcI3)
1uniprot[Pubmed] 17151343
Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007]
7
 Q7WT16_9ACTO
(Q7WT16)		 Jump to Medem_00260 
[query] 25 - 156 (160)
[subject] 10 - 141 (146)
 7e-31 137   52%
Product
Putative uncharacterized protein med-ORF10
Gene
med-ORF10
Organism
Streptomyces sp. AM-7161
1uniprot
Cloning, sequencing and heterologous expression of the medermycin biosynthetic gene cluster of Streptomyces sp. AM-7161: towards comparative analysis of the benzoisochromanequione gene clusters.(Microbiology (Mosc.)) [2003]
10
 Q9ZA28_STRVN
(Q9ZA28)		 Jump to Grana_00310 
[query] 25 - 157 (160)
[subject] 10 - 140 (142)
 3e-26 122   50%
Product
Gra-orf31 protein
Gene
gra-orf31
Organism
Streptomyces violaceoruber
1uniprot[Pubmed] 2583128 [Medline] 90060034
Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber Tu22.(EMBO J.) [1989]
2uniprot[Pubmed] 7476861 [Medline] 96027933
Identification of Streptomyces violaceoruber Tu22 genes involved in the biosynthesis of granaticin.(Mol. Gen. Genet.) [1995]
3uniprot[Pubmed] 9831526 [Medline] 99051446
The granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tu22: sequence analysis and expression in a heterologous host.(Chem. Biol.) [1998]
[pubmed all]
14
 C7PWR4_CATAD
(C7PWR4)		 
[query] 18 - 156 (160)
[subject] 3 - 142 (154)
 2e-24 115   50%
Product
Aromatic-ring-hydroxylating dioxygenase beta subunit
Gene
Caci_6494
Organism
Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
1uniprot
Complete genome sequence of Catenulispora acidiphila type strain (ID 139908).(Stand. Genomic Sci.) [2009]
15
 Q54278_SACHI
(Q54278)		 
[query] 25 - 159 (160)
[subject] 10 - 142 (147)
 2e-23 112   50%
Product
DNA-binding protein
Gene
 
Organism
Saccharopolyspora hirsuta
1uniprot[Pubmed] 8341260 [Medline] 93341453
Saccharopolyspora hirsuta 367 encodes clustered genes similar to ketoacyl synthase, ketoacyl reductase, acyl carrier protein, and biotin carboxyl carrier protein.(Mol. Gen. Genet.) [1993]
17
 Q53925_STRCO
(Q53925)		 Jump to Actino_00020 
[query] 24 - 159 (160)
[subject] 9 - 144 (146)
 3e-21 105   42%
Product
Hydroxylacyl-CoA dehydrogenase
Gene
ORFA
SCO5071
Organism
Streptomyces coelicolor
1uniprot[Pubmed] 12000953 [Medline] 21996410
Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).(Nature) [2002]
2uniprot[Pubmed] 7929165 [Medline] 95014254
DNA sequence and functions of the actVI region of the actinorhodin biosynthetic gene cluster of Streptomyces coelicolor A3(2).(J. Biol. Chem.) [1994]
[pubmed all]
18
 B2HGM9_MYCMM
(B2HGM9)		 
[query] 8 - 156 (160)
[subject] 6 - 151 (153)
 2e-19 99.4 38%
Product
Putative uncharacterized protein
Gene
MMAR_1563
Organism
Mycobacterium marinum (strain ATCC BAA-535 / M)
1uniprot[Pubmed] 18403782
Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis.(Genome Res.) [2008]
20
 C0JWC8_9ACTO
(C0JWC8)		 Jump to Polk_00330 
[query] 24 - 156 (160)
[subject] 14 - 144 (150)
 3e-18 95.1 46%
Product
PokC1
Gene
pokC1
Organism
Streptomyces diastatochromogenes
1uniprot[Pubmed] 19266534
Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009]
22
 Q53879_STRS5
(Q53879)		 Jump to Dauno_00030 
[query] 24 - 156 (160)
[subject] 21 - 148 (151)
 3e-16 88.6 46%
Product
Putative uncharacterized protein
Gene
 
Organism
Streptomyces sp. (strain C5)
1uniprot[Pubmed] 8655529 [Medline] 96236066
Cloning, sequencing, and analysis of aklaviketone reductase from Streptomyces sp. strain C5.(J. Bacteriol.) [1996]
24
 D6MSU8_9ACTO
(D6MSU8)		 
[query] 40 - 156 (160)
[subject] 4 - 119 (123)
 1e-14 83.6 43%
Product
SsfY4
Gene
ssfY4
Organism
Streptomyces sp. SF2575
1uniprot[Pubmed] 19908837
Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.(J. Am. Chem. Soc.) [2009]
25
 Q3S8Q7_STRRM
(Q3S8Q7)		 Jump to Oxtet_00090 
[query] 24 - 156 (160)
[subject] 15 - 145 (150)
 1e-14 83.2 41%
Product
OxyI
Gene
oxyI
Organism
Streptomyces rimosus
1uniprot[Pubmed] 16597959
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.(Appl. Environ. Microbiol.) [2006]
27
 B6SEE8_9ACTO
(B6SEE8)		 Jump to Alnu_00030 
[query] 22 - 156 (160)
[subject] 33 - 162 (172)
 1e-13 79.7 41%
Product
Aln2
Gene
aln2
Organism
Streptomyces sp. CM020
1uniprot[Pubmed] 18940666
Characterization of the alnumycin gene cluster reveals unusual gene products for pyran ring formation and dioxan biosynthesis.(Chem. Biol.) [2008]
28
 Q9L4U3_9ACTO
(Q9L4U3)		 Jump to Acla_00240 
[query] 23 - 156 (160)
[subject] 10 - 141 (144)
 2e-13 79.3 41%
Product
AknV
Gene
aknV
Organism
Streptomyces galilaeus
1uniprot[Pubmed] 11016846 [Medline] 20469061
A gene cluster from Streptomyces galilaeus involved in glycosylation of aclarubicin.(Mol. Gen. Genet.) [2000]
29
 Q9ZAT9_STRPE
(Q9ZAT9)		 Jump to Adria_00050 
[query] 24 - 156 (160)
[subject] 64 - 191 (194)
 2e-13 79   42%
Product
Daunorubicin biosynthesis enzyme
Gene
dpsH
Organism
Streptomyces peucetius
1uniprot[Pubmed] 8955419 [Medline] 97113559
Enhanced antibiotic production by manipulation of the Streptomyces peucetius dnrH and dnmT genes involved in doxorubicin (adriamycin) biosynthesis.(J. Bacteriol.) [1996]
2uniprot[Pubmed] 9864344 [Medline] 99084971
Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene.(J. Bacteriol.) [1999]
[pubmed all]
30
 Q53670_STRAA
(Q53670)		 Jump to Mith_00130 
[query] 16 - 156 (160)
[subject] 9 - 147 (150)
 3e-13 79   39%
Product
Cyclase
Gene
mtmX
Organism
Streptomyces argillaceus
1uniprot[Pubmed] 8654997 [Medline] 96257259
Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144
An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479
Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047
Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478
Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236
Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456
Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776
The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809
Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752
The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297
Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254
Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461
Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994
Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398
Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238
Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589
MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823
Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316
Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873
The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]
[pubmed all]
31
 D1A615_THECD
(D1A615)		 
[query] 22 - 157 (160)
[subject] 12 - 143 (146)
 5e-13 77.8 40%
Product
Putative uncharacterized protein
Gene
Tcur_2764
Organism
Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
1uniprot
Complete genome sequence of Thermomonospora curvata type strain (B9).(Stand. Genomic Sci.) [2011]
35
 B8Y4H2_STRAU
(B8Y4H2)		 
[query] 22 - 159 (160)
[subject] 17 - 147 (147)
 2e-12 75.9 38%
Product
Putative cyclase
Gene
sa16
Organism
Streptomyces aureofaciens
1uniprot[Pubmed] 20490753
Identification and characterization of an indigoidine-like gene for a blue pigment biosynthesis in Streptomyces aureofaciens CCM 3239.(Folia Microbiol. (Praha)) [2010]
36
 B8Y4G8_STRAU
(B8Y4G8)		 
[query] 23 - 156 (160)
[subject] 19 - 151 (156)
 2e-12 75.9 39%
Product
Putative cyclase
Gene
sa12
Organism
Streptomyces aureofaciens
1uniprot[Pubmed] 20490753
Identification and characterization of an indigoidine-like gene for a blue pigment biosynthesis in Streptomyces aureofaciens CCM 3239.(Folia Microbiol. (Praha)) [2010]
37
 Q9RN65_STRNO
(Q9RN65)		 Jump to Nogl_00140 
[query] 4 - 156 (160)
[subject] 8 - 154 (155)
 4e-12 74.7 42%
Product
SnoO
Gene
snoO
Organism
Streptomyces nogalater
1uniprot[Pubmed] 9349712 [Medline] 98007868
Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.(Mol. Gen. Genet.) [1997]
2uniprot[Pubmed] 10639368 [Medline] 20106987
Identification of a cyclase gene dictating the C-9 stereochemistry of anthracyclines from Streptomyces nogalater.(Antimicrob. Agents Chemother.) [2000]
[pubmed all]
38
 Q2J5F3_FRASC
(Q2J5F3)		 
[query] 23 - 156 (160)
[subject] 14 - 145 (150)
 8e-12 73.9 39%
Product
Hydroxylacyl-CoA dehydrogenase
Gene
Francci3_4141
Organism
Frankia sp. (strain CcI3)
1uniprot[Pubmed] 17151343
Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007]
39
 D7BZR6_STRBB
(D7BZR6)		 
[query] 16 - 156 (160)
[subject] 11 - 149 (152)
 1e-11 73.6 38%
Product
Hydroxylacyl-CoA dehydrogenase
Gene
SBI_06851
Organism
Streptomyces bingchenggensis (strain BCW-1)
1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]
41
 Q9L554_9ACTO
(Q9L554)		 Jump to Acla_00040 
[query] 24 - 156 (160)
[subject] 320 - 448 (450)
 4e-11 71.6 42%
Product
AknE1
Gene
aknE1
Organism
Streptomyces galilaeus
1uniprot[Pubmed] 12137949 [Medline] 22133312
Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster.(Gene) [2002]
42
 Q4R0M5_STRCX
(Q4R0M5)		 Jump to Chart_00070 
[query] 25 - 156 (160)
[subject] 13 - 141 (145)
 1e-10 70.1 39%
Product
Putative uncharacterized protein chaN
Gene
chaN
Organism
Streptomyces chartreusis
1uniprot[Pubmed] 15911378
Biosynthesis of the antitumor agent chartreusin involves the oxidative rearrangement of an anthracyclic polyketide.(Chem. Biol.) [2005]
43
 Q8VWB6_9ACTO
(Q8VWB6)		 
[query] 11 - 156 (160)
[subject] 311 - 448 (450)
 3e-10 68.6 40%
Product
AknE1
Gene
aknE1
Organism
Streptomyces galilaeus
1uniprot[Pubmed] 12399480 [Medline] 22286521
Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus.(J. Bacteriol.) [2002]
44
 Q2PA04_9ACTO
(Q2PA04)		 Jump to Stref_00110 
[query] 25 - 156 (160)
[subject] 13 - 143 (146)
 2e-09 66.2 36%
Product
Cyclase
Gene
stfX
Organism
Streptomyces steffisburgensis
1uniprot[Pubmed] 16751529
Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin.(Appl. Environ. Microbiol.) [2006]
45
 Q9KHL2_9ACTO
(Q9KHL2)		 Jump to Enter_00030 
[query] 16 - 156 (160)
[subject] 20 - 158 (163)
 2e-08 62.8 31%
Product
EncG
Gene
encG
Organism
Streptomyces maritimus
1uniprot
Natural Metabolic Diversity Encoded by the Enterocin Biosynthesis Gene Cluster.(J. Am. Chem. Soc.) [2000]
2uniprot[Pubmed] 11137817 [Medline] 20579517
Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate 'Streptomyces maritimus': evidence for the derailment of an aromatic polyketide synthase.(Chem. Biol.) [2000]
3uniprot[Pubmed] 11948863 [Medline] 21942282
A mechanism of benzoic acid biosynthesis in plants and bacteria that mirrors fatty acid beta-oxidation.(Chembiochem) [2001]
[pubmed all]
46
 E1ARK7_STRAU
(E1ARK7)		 
[query] 25 - 146 (160)
[subject] 20 - 143 (156)
 1e-07 60.1 37%
Product
Putative cyclase
Gene
sa45
Organism
Streptomyces aureofaciens
1uniprot[Pubmed] 21393365
The role of two SARP family transcriptional regulators in regulation of the auricin gene cluster in Streptomyces aureofaciens CCM 3239.(Microbiology) [2011]
47
 Q2J5F8_FRASC
(Q2J5F8)		 
[query] 22 - 156 (160)
[subject] 13 - 148 (152)
 3e-06 55.5 34%
Product
Putative uncharacterized protein
Gene
Francci3_4136
Organism
Frankia sp. (strain CcI3)
1uniprot[Pubmed] 17151343
Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007]
49
 E4WAC6_RHOE1
(E4WAC6)		 
[query] 23 - 156 (160)
[subject] 13 - 144 (150)
 1e-05 53.5 35%
Product
Putative uncharacterized protein
Gene
REQ_44380
Organism
Rhodococcus equi (strain 103S)
Corynebacterium equi
1uniprot[Pubmed] 20941392
The genome of a pathogenic rhodococcus: cooptive virulence underpinned by key gene acquisitions.(PLoS Genet.) [2010]
51
 D7AZ66_NOCDD
(D7AZ66)		 
[query] 23 - 158 (160)
[subject] 3 - 136 (137)
 0.0005 48.1 33%
Product
Aromatic-ring-hydroxylating dioxygenase beta subunit
Gene
Ndas_4660
Organism
Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei
1uniprot
Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010]