| accession | DB | alignment | Evalue | Score | Ident. | link | information | pubmed |
1
|
Q49BE1_STRHY (Q49BE1) |
|
|
0.0 |
13480 |
100% |
|
- Product
- HbmAI
- Gene
- hbmAI
- Organism
- Streptomyces hygroscopicus
|
1uniprot[Pubmed] 16085885 Insights into the biosynthesis of the benzoquinone ansamycins geldanamycin and herbimycin, obtained by gene sequencing and disruption.(Appl. Environ. Microbiol.) [2005] |
|
2
|
Q84G24_STRHY (Q84G24) |
|
|
0.0 |
12260 |
93% |
|
- Product
- GdmAI
- Gene
- gdmAI
- Organism
- Streptomyces hygroscopicus
|
1uniprot[Pubmed] 12586396 [Medline] 22474162 Cloning and characterization of a gene cluster for geldanamycin production in Streptomyces hygroscopicus NRRL 3602.(FEMS Microbiol. Lett.) [2003] |
|
3
|
Q1L0T2_STRHY (Q1L0T2) |
|
|
0.0 |
12250 |
93% |
|
- Product
- GelA
- Gene
-
- Organism
- Streptomyces hygroscopicus subsp. duamyceticus
|
1uniprot[Pubmed] 18600054 Characterization of tailoring genes involved in the modification of geldanamycin polyketide in Streptomyces hygroscopicus JCM4427.(J. Microbiol. Biotechnol.) [2008] |
|
4
|
F1CT51_9ACTO (F1CT51) |
|
|
0.0 |
11610 |
89% |
|
- Product
- GdmAI
- Gene
- gdmAI
- Organism
- Streptomyces autolyticus
|
1uniprot[Pubmed] 21544574 Streptomyces autolyticus JX-47 Large-Insert Bacterial Artificial Chromosome Library Construction and Identification of Clones Covering Geldanamycin Biosynthesis Gene Cluster.(Curr. Microbiol.) [2011] |
|
5
|
C6W8V1_ACTMD (C6W8V1) |
|
|
0.0 |
7838 |
64% |
|
- Product
- Acyl transferase
- Gene
- Amir_3294
- Organism
- Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971)
|
1uniprot Complete genome sequence of Actinosynnema mirum type strain (101).(Stand. Genomic Sci.) [2009] |
|
9
|
A4KCE5_9ACTO (A4KCE5) |
|
(13 hsp) |
0.0 |
4328 |
51% |
|
- Product
- Tautomycetin biosynthetic PKS
- Gene
-
- Organism
- Streptomyces sp. CK4412
|
1uniprot[Pubmed] 17379718 Isolation of the biosynthetic gene cluster for tautomycetin, a linear polyketide T cell-specific immunomodulator from Streptomyces sp. CK4412.(Microbiology) [2007] | 2uniprot[Pubmed] 20623733 Biochemical and structural characterization of the tautomycetin thioesterase: analysis of a stereoselective polyketide hydrolase.(Angew. Chem. Int. Ed.) [2010] | [pubmed all]
|
10
|
C6ZCS0_9ACTO (C6ZCS0) |
|
(13 hsp) |
0.0 |
4311 |
51% |
|
- Product
- Type I modular polyketide synthase
- Gene
- ttnB
- Organism
- Streptomyces griseochromogenes
|
1uniprot[Pubmed] 19191560 Characterization of the Tautomycetin Biosynthetic Gene Cluster from Streptomyces griseochromogenes Provides New Insight into Dialkylmaleic Anhydride Biosynthesis.(J. Nat. Prod.) [2009] |
|
11
|
Q6W5P7_9ACTO (Q6W5P7) |
|
(11 hsp) |
0.0 |
4261 |
48% |
|
- Product
- FscE
- Gene
- fscE
- Organism
- Streptomyces sp. FR-008
|
1uniprot[Pubmed] 14652074 Organizational and Mutational Analysis of a Complete FR-008/Candicidin Gene Cluster Encoding a Structurally Related Polyene Complex.(Chem. Biol.) [2003] |
|
15
|
Q84G22_STRHY (Q84G22) |
|
(10 hsp) |
0.0 |
4063 |
63% |
|
- Product
- GdmAIII
- Gene
- gdmAIII
- Organism
- Streptomyces hygroscopicus
|
1uniprot[Pubmed] 12586396 [Medline] 22474162 Cloning and characterization of a gene cluster for geldanamycin production in Streptomyces hygroscopicus NRRL 3602.(FEMS Microbiol. Lett.) [2003] |
|
16
|
Q1L0T0_STRHY (Q1L0T0) |
|
(10 hsp) |
0.0 |
4056 |
63% |
|
- Product
- GelC
- Gene
-
- Organism
- Streptomyces hygroscopicus subsp. duamyceticus
|
1uniprot[Pubmed] 18600054 Characterization of tailoring genes involved in the modification of geldanamycin polyketide in Streptomyces hygroscopicus JCM4427.(J. Microbiol. Biotechnol.) [2008] |
|
17
|
F1CT53_9ACTO (F1CT53) |
|
(10 hsp) |
0.0 |
4011 |
63% |
|
- Product
- GdmAIII
- Gene
- gdmAIII
- Organism
- Streptomyces autolyticus
|
1uniprot[Pubmed] 21544574 Streptomyces autolyticus JX-47 Large-Insert Bacterial Artificial Chromosome Library Construction and Identification of Clones Covering Geldanamycin Biosynthesis Gene Cluster.(Curr. Microbiol.) [2011] |
|
19
|
Q49BD9_STRHY (Q49BD9) |
|
(10 hsp) |
0.0 |
3978 |
63% |
|
- Product
- HbmAIII
- Gene
- hbmAIII
- Organism
- Streptomyces hygroscopicus
|
1uniprot[Pubmed] 16085885 Insights into the biosynthesis of the benzoquinone ansamycins geldanamycin and herbimycin, obtained by gene sequencing and disruption.(Appl. Environ. Microbiol.) [2005] |
|
20
|
A1YAM7_AMYOR (A1YAM7) |
|
(12 hsp) |
0.0 |
3865 |
52% |
|
- Product
- Polyketide synthase type I
- Gene
-
- Organism
- Amycolatopsis orientalis
Nocardia orientalis
|
1uniprot[Pubmed] 17136886 Genomic analyses lead to novel secondary metabolites. Part 3. ECO-0501, a novel antibacterial of a new class.(J. Antibiot.) [2006] |
|
21
|
A4FDM8_SACEN (A4FDM8) |
|
(10 hsp) |
0.0 |
3757 |
54% |
|
- Product
- Modular polyketide synthase-
- Gene
- SACE_2875
- Organism
- Saccharopolyspora erythraea (strain NRRL 23338)
|
1uniprot[Pubmed] 17369815 Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007] |
|
22
|
D7CC08_STRBB (D7CC08) |
|
(8 hsp) |
0.0 |
3656 |
52% |
|
- Product
- Putative type I polyketide synthase
- Gene
- pks5-2
SBI_01382
- Organism
- Streptomyces bingchenggensis (strain BCW-1)
|
1uniprot[Pubmed] 20581206 Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010] |
|
23
|
B6ZK65_STRLS (B6ZK65) |
|
(8 hsp) |
0.0 |
3599 |
53% |
|
- Product
- Putative polyketide synthase
- Gene
- lsd12
- Organism
- Streptomyces lasaliensis
|
1uniprot[Pubmed] 19129623 Identification of a gene cluster of polyether antibiotic lasalocid from Streptomyces lasaliensis.(Biosci. Biotechnol. Biochem.) [2009] | 2uniprot[Pubmed] 18710235 Epoxide hydrolase Lsd19 for polyether formation in the biosynthesis of lasalocid A: direct experimental evidence on polyene-polyepoxide hypothesis in polyether biosynthesis.(J. Am. Chem. Soc.) [2008] | [pubmed all]
|
26
|
B2HF44_MYCMM (B2HF44) |
|
(5 hsp) |
0.0 |
3513 |
49% |
|
- Product
- Polyketide synthase, Pks12
- Gene
- pks12
MMAR_3025
- Organism
- Mycobacterium marinum (strain ATCC BAA-535 / M)
|
1uniprot[Pubmed] 18403782 Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis.(Genome Res.) [2008] |
|
27
|
A0PQM7_MYCUA (A0PQM7) |
|
(5 hsp) |
0.0 |
3513 |
49% |
|
- Product
- Polyketide synthase, Pks12
- Gene
- pks12
MUL_2266
- Organism
- Mycobacterium ulcerans (strain Agy99)
|
1uniprot[Pubmed] 17210928 Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer.(Genome Res.) [2007] |
|
28
|
Q7VES2_MYCBO (Q7VES2) |
|
(5 hsp) |
0.0 |
3512 |
50% |
|
- Product
- Probable polyketide synthase pks12
- Gene
- pks12
Mb2074c
- Organism
- Mycobacterium bovis
|
1uniprot[Pubmed] 12788972 [Medline] 22709107 The complete genome sequence of Mycobacterium bovis.(Proc. Natl. Acad. Sci. U.S.A.) [2003] |
|
30
|
C1APW8_MYCBT (C1APW8) |
|
(5 hsp) |
0.0 |
3487 |
50% |
|
- Product
- Putative polyketide synthase
- Gene
- pks12
JTY_2062
- Organism
- Mycobacterium bovis (strain BCG / Tokyo 172 / ATCC 35737 / TMC 1019)
|
1uniprot[Pubmed] 19200449 Whole genome sequence analysis of Mycobacterium bovis bacillus Calmette-Guerin (BCG) Tokyo 172: a comparative study of BCG vaccine substrains.(Vaccine) [2009] |
|
31
|
A1KK94_MYCBP (A1KK94) |
|
(5 hsp) |
0.0 |
3487 |
50% |
|
- Product
- Probable polyketide synthase pks12
- Gene
- pks12
BCG_2067c
- Organism
- Mycobacterium bovis (strain BCG / Pasteur 1173P2)
|
1uniprot[Pubmed] 17372194 Genome plasticity of BCG and impact on vaccine efficacy.(Proc. Natl. Acad. Sci. U.S.A.) [2007] |
|
37
|
O53490_MYCTU (O53490) |
|
(5 hsp) |
0.0 |
3474 |
50% |
|
- Product
- Probable polyketide synthase pks12
- Gene
- pks12
Rv2048c
- Organism
- Mycobacterium tuberculosis
|
1uniprot[Pubmed] 9634230 [Medline] 98295987 Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.(Nature) [1998] |
|
38
|
Q7D7J7_MYCTU (Q7D7J7) |
|
(5 hsp) |
0.0 |
3474 |
50% |
|
- Product
- Polyketide synthase
- Gene
- MT2108
- Organism
- Mycobacterium tuberculosis
|
1uniprot[Pubmed] 12218036 [Medline] 22206494 Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.(J. Bacteriol.) [2002] |
|
41
|
Q9ADL6_SORCE (Q9ADL6) |
|
(12 hsp) |
0.0 |
3462 |
47% |
|
- Product
- Soraphen polyketide synthase A
- Gene
- sorA
- Organism
- Sorangium cellulosum
Polyangium cellulosum
|
1uniprot[Pubmed] 12039053 [Medline] 22035375 Characterization of the biosynthetic gene cluster for the antifungal polyketide soraphen A from Sorangium cellulosum So ce26.(Gene) [2002] |
|
42
|
Q73Z07_MYCPA (Q73Z07) |
|
(5 hsp) |
0.0 |
3425 |
50% |
|
- Product
- Pks12
- Gene
- pks12
MAP_1796c
- Organism
- Mycobacterium paratuberculosis
|
1uniprot[Pubmed] 16116077 The complete genome sequence of Mycobacterium avium subspecies paratuberculosis.(Proc. Natl. Acad. Sci. U.S.A.) [2005] |
|
44
|
C0SMW4_9ACTO (C0SMW4) |
|
(24 hsp) |
0.0 |
3338 |
50% |
|
- Product
- Type I modular polyketide synthase
- Gene
- ttmJ
- Organism
- Streptomyces spiroverticillatus
|
1uniprot[Pubmed] 16707708 Utilization of the methoxymalonyl-acyl carrier protein biosynthesis locus for cloning of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus.(J. Bacteriol.) [2006] | 2uniprot[Pubmed] 18708355 Characterization of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus unveiling new insights into dialkylmaleic anhydride and polyketide biosynthesis.(J. Biol. Chem.) [2008] | [pubmed all]
|
45
|
C6W8U9_ACTMD (C6W8U9) |
|
(9 hsp) |
0.0 |
3267 |
55% |
|
- Product
- Short-chain dehydrogenase/reductase SDR
- Gene
- Amir_3292
- Organism
- Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971)
|
1uniprot Complete genome sequence of Actinosynnema mirum type strain (101).(Stand. Genomic Sci.) [2009] |
|
47
|
Q1WEK8_9ACTO (Q1WEK8) |
|
(16 hsp) |
0.0 |
3245 |
50% |
|
- Product
- Polyketide synthase
- Gene
- merB
- Organism
- Streptomyces sp. NRRL 30748
|
1uniprot[Pubmed] 16806745 Isolation and characterization of meridamycin biosynthetic gene cluster from Streptomyces sp. NRRL 30748.(Gene) [2006] |
|
48
|
A0FCL2_STRVO (A0FCL2) |
|
(14 hsp) |
0.0 |
3224 |
49% |
|
- Product
- MerB
- Gene
- merB
- Organism
- Streptomyces violaceoniger
|
1uniprot[Pubmed] 17159202 Organization of the biosynthetic gene cluster in Streptomyces sp. DSM 4137 for the novel neuroprotectant polyketide meridamycin.(Microbiology) [2006] |
|
51
|
Q54297_STRHY (Q54297) |
|
(15 hsp) |
0.0 |
3174 |
50% |
|
- Product
- Polyketide synthase
- Gene
- rapA
- Organism
- Streptomyces hygroscopicus
|
1uniprot[Pubmed] 7644502 [Medline] 95372374 The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin.(Proc. Natl. Acad. Sci. U.S.A.) [1995] | 2uniprot[Pubmed] 8635730 [Medline] 96186895 Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase.(Gene) [1996] | 3uniprot[Pubmed] 8635756 [Medline] 96186896 Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase.(Gene) [1996] | [pubmed all]
|
52
|
Q6JHN6_9PSEU (Q6JHN6) |
|
(15 hsp) |
0.0 |
3161 |
49% |
|
- Product
- ObsC
- Gene
-
- Organism
- Saccharopolyspora spinosa
|
1uniprot[Pubmed] 15346767 Analysis of a 108-kb region of the Saccharopolyspora spinosa genome covering the obscurin polyketide synthase locus.(DNA Seq.) [2004] |
|
53
|
A4F5C6_SORCE (A4F5C6) |
|
(9 hsp) |
0.0 |
3160 |
47% |
|
- Product
- Polyketide synthase
- Gene
- spiG
- Organism
- Sorangium cellulosum
Polyangium cellulosum
|
1uniprot[Pubmed] 17317575 Spiroketal polyketide formation in Sorangium: Identification of the biosynthetic gene cluster for the highly cytotoxic spirangienes.(Chem. Biol.) [2007] |
|
54
|
Q06BM4_STRHY (Q06BM4) |
|
(9 hsp) |
0.0 |
3153 |
64% |
|
- Product
- GdmPKS
- Gene
- gdmPKS
- Organism
- Streptomyces hygroscopicus
|
1uniprot[Pubmed] 18214443 The LuxR family members GdmRI and GdmRII are positive regulators of geldanamycin biosynthesis in Streptomyces hygroscopicus 17997.(Arch. Microbiol.) [2008] |
|
55
|
Q53840_SORCE (Q53840) |
|
(17 hsp) |
0.0 |
3143 |
47% |
|
- Product
- Soraphen polyketide synthase B
- Gene
- sorB
- Organism
- Sorangium cellulosum
Polyangium cellulosum
|
1uniprot[Pubmed] 7601830 [Medline] 95325306 A Sorangium cellulosum (myxobacterium) gene cluster for the biosynthesis of the macrolide antibiotic soraphen A: cloning, characterization, and homology to polyketide synthase genes from actinomycetes.(J. Bacteriol.) [1995] | 2uniprot[Pubmed] 12039053 [Medline] 22035375 Characterization of the biosynthetic gene cluster for the antifungal polyketide soraphen A from Sorangium cellulosum So ce26.(Gene) [2002] | [pubmed all]
|
56
|
Q52V50_9ACTO (Q52V50) |
|
(15 hsp) |
0.0 |
3124 |
48% |
|
- Product
- Polyketide synthase type I
- Gene
-
- Organism
- Streptomyces aizunensis
|
1uniprot[Pubmed] 15844935 Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example.(J. Nat. Prod.) [2005] |
|
58
|
A0ACH1_STRAM (A0ACH1) |
|
(14 hsp) |
0.0 |
3097 |
49% |
|
- Product
- Putative polyketide synthase B
- Gene
- SAMR0465
- Organism
- Streptomyces ambofaciens ATCC 23877
|
1uniprot[Pubmed] 16956972 Evolution of the terminal regions of the Streptomyces linear chromosome.(Mol. Biol. Evol.) [2006] | 2uniprot Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877.(Microbiology (Mosc.)) [2006] |
|
60
|
C0SMW2_9ACTO (C0SMW2) |
|
(12 hsp) |
0.0 |
3070 |
48% |
|
- Product
- Type I modular polyketide synthase
- Gene
- ttmH
- Organism
- Streptomyces spiroverticillatus
|
1uniprot[Pubmed] 16707708 Utilization of the methoxymalonyl-acyl carrier protein biosynthesis locus for cloning of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus.(J. Bacteriol.) [2006] | 2uniprot[Pubmed] 18708355 Characterization of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus unveiling new insights into dialkylmaleic anhydride and polyketide biosynthesis.(J. Biol. Chem.) [2008] | [pubmed all]
|
61
|
Q6MZA4_MYCUA (Q6MZA4) |
|
(25 hsp) |
0.0 |
3068 |
46% |
|
- Product
- Type I modular polyketide synthase
- Gene
- mlsA1
MUP040c
- Organism
- Mycobacterium ulcerans (strain Agy99)
|
1uniprot[Pubmed] 15758215 Functional analysis and annotation of the virulence plasmid pMUM001 from Mycobacterium ulcerans.(Microbiology) [2005] | 2uniprot[Pubmed] 14736915 Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans.(Proc. Natl. Acad. Sci. U.S.A.) [2004] | [pubmed all]
|
63
|
E0D203_9ACTO (E0D203) |
|
(12 hsp) |
0.0 |
3046 |
51% |
|
- Product
- Polyketide synthase
- Gene
- gfsB
- Organism
- Streptomyces graminofaciens
|
1uniprot[Pubmed] 20589823 Cloning and characterization of the biosynthetic gene cluster of 16-membered macrolide antibiotic FD-891: involvement of a dual functional cytochrome P450 monooxygenase catalyzing epoxidation and hydroxylation.(Chembiochem) [2010] |
|
64
|
Q6W5P9_9ACTO (Q6W5P9) |
|
(11 hsp) |
0.0 |
3039 |
49% |
|
- Product
- FscB
- Gene
- fscB
- Organism
- Streptomyces sp. FR-008
|
1uniprot[Pubmed] 14652074 Organizational and Mutational Analysis of a Complete FR-008/Candicidin Gene Cluster Encoding a Structurally Related Polyene Complex.(Chem. Biol.) [2003] |
|
65
|
Q54296_STRHY (Q54296) |
|
(23 hsp) |
0.0 |
3017 |
48% |
|
- Product
- Polyketide synthase
- Gene
- rapB
- Organism
- Streptomyces hygroscopicus
|
1uniprot[Pubmed] 7644502 [Medline] 95372374 The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin.(Proc. Natl. Acad. Sci. U.S.A.) [1995] | 2uniprot[Pubmed] 8635730 [Medline] 96186895 Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase.(Gene) [1996] | 3uniprot[Pubmed] 8635756 [Medline] 96186896 Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase.(Gene) [1996] | [pubmed all]
|
66
|
B5L6M3_MICCH (B5L6M3) |
|
(8 hsp) |
0.0 |
3014 |
50% |
|
- Product
- Putative type I polyketide synthase
- Gene
-
- Organism
- Micromonospora chalcea
|
1uniprot[Pubmed] 18586939 Cloning and characterization of the tetrocarcin A gene cluster from Micromonospora chalcea NRRL 11289 reveals a highly conserved strategy for tetronate biosynthesis in spirotetronate antibiotics.(J. Bacteriol.) [2008] |
|
68
|
Q93NW6_9ACTO (Q93NW6) |
|
(23 hsp) |
0.0 |
2991 |
48% |
|
- Product
- AmphC
- Gene
- amphC
- Organism
- Streptomyces nodosus
|
1uniprot[Pubmed] 11451671 [Medline] 21344785 Amphotericin biosynthesis in Streptomyces nodosus: deductions from analysis of polyketide synthase and late genes.(Chem. Biol.) [2001] | 2uniprot[Pubmed] 16079135 Biosynthesis of amphotericin derivatives lacking exocyclic carboxyl groups.(J. Biol. Chem.) [2005] | [pubmed all]
|
70
|
A0FCL3_STRVO (A0FCL3) |
|
(23 hsp) |
0.0 |
2965 |
46% |
|
- Product
- MerC
- Gene
- merC
- Organism
- Streptomyces violaceoniger
|
1uniprot[Pubmed] 17159202 Organization of the biosynthetic gene cluster in Streptomyces sp. DSM 4137 for the novel neuroprotectant polyketide meridamycin.(Microbiology) [2006] |
|
71
|
D6C477_9ACTO (D6C477) |
|
(13 hsp) |
0.0 |
2961 |
51% |
|
- Product
- Modular polyketide synthase
- Gene
- meiA3
- Organism
- Streptomyces nanchangensis
|
1uniprot[Pubmed] 12811466 [Medline] 22777186 Identification of a gene cluster encoding meilingmycin biosynthesis among multiple polyketide synthase contigs isolated from Streptomyces nanchangensis NS3226.(Arch. Microbiol.) [2003] | 2uniprot[Pubmed] 20348291 Cloning of separate meilingmycin biosynthesis gene clusters by use of acyltransferase-ketoreductase didomain PCR amplification.(Appl. Environ. Microbiol.) [2010] | [pubmed all]
|
72
|
Q0R4M3_STRAT (Q0R4M3) |
|
(9 hsp) |
0.0 |
2961 |
50% |
|
- Product
- ChlA5
- Gene
-
- Organism
- Streptomyces antibioticus
|
1uniprot[Pubmed] 16793515 Genetic characterization of the chlorothricin gene cluster as a model for spirotetronate antibiotic biosynthesis.(Chem. Biol.) [2006] |
|
73
|
B3TMP1_9ACTO (B3TMP1) |
|
(9 hsp) |
0.0 |
2909 |
50% |
|
- Product
- Polyketide synthase
- Gene
- KijS4
- Organism
- Actinomadura kijaniata
|
1uniprot[Pubmed] 17985890 Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007] |
|
74
|
A0ACH2_STRAM (A0ACH2) |
|
(6 hsp) |
0.0 |
2891 |
49% |
|
- Product
- Putative polyketide synthase B
- Gene
- SAMR0466
- Organism
- Streptomyces ambofaciens ATCC 23877
|
1uniprot[Pubmed] 16956972 Evolution of the terminal regions of the Streptomyces linear chromosome.(Mol. Biol. Evol.) [2006] | 2uniprot Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877.(Microbiology (Mosc.)) [2006] |
|
75
|
D7C2B8_STRBB (D7C2B8) |
|
(14 hsp) |
0.0 |
2888 |
47% |
|
- Product
- Type I modular polyketide synthase
- Gene
- pks3-2
SBI_00651
- Organism
- Streptomyces bingchenggensis (strain BCW-1)
|
1uniprot[Pubmed] 20581206 Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010] |
|
76
|
C0SMW3_9ACTO (C0SMW3) |
|
(8 hsp) |
0.0 |
2877 |
48% |
|
- Product
- Type I modular polyketide synthase
- Gene
- ttmI
- Organism
- Streptomyces spiroverticillatus
|
1uniprot[Pubmed] 16707708 Utilization of the methoxymalonyl-acyl carrier protein biosynthesis locus for cloning of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus.(J. Bacteriol.) [2006] | 2uniprot[Pubmed] 18708355 Characterization of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus unveiling new insights into dialkylmaleic anhydride and polyketide biosynthesis.(J. Biol. Chem.) [2008] | [pubmed all]
|
78
|
Q54299_STRHY (Q54299) |
|
(15 hsp) |
0.0 |
2850 |
50% |
|
- Product
- Polyketide synthase
- Gene
- rapC
- Organism
- Streptomyces hygroscopicus
|
1uniprot[Pubmed] 7644502 [Medline] 95372374 The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin.(Proc. Natl. Acad. Sci. U.S.A.) [1995] | 2uniprot[Pubmed] 8635730 [Medline] 96186895 Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase.(Gene) [1996] | 3uniprot[Pubmed] 8635756 [Medline] 96186896 Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase.(Gene) [1996] | [pubmed all]
|
79
|
Q76KY0_STRHA (Q76KY0) |
|
(14 hsp) |
0.0 |
2847 |
48% |
|
- Product
- Polyketide synthase modules 1-3
- Gene
- vinP1
- Organism
- Streptomyces halstedii
|
1uniprot[Pubmed] 15112997 Cloning, sequencing, and functional analysis of the biosynthetic gene cluster of macrolactam antibiotic vicenistatin in Streptomyces halstedii.(Chem. Biol.) [2004] |
|
81
|
D2CKM4_PSEAH (D2CKM4) |
|
(24 hsp) |
0.0 |
2814 |
48% |
|
- Product
- CppC
- Gene
- cppC
- Organism
- Pseudonocardia autotrophica
Amycolata autotrophica Nocardia autotrophica
|
1uniprot[Pubmed] 19697072 Identification of functionally clustered nystatin-like biosynthetic genes in a rare actinomycetes, Pseudonocardia autotrophica.(J. Ind. Microbiol. Biotechnol.) [2009] |
|
82
|
Q93NX8_9ACTO (Q93NX8) |
|
(12 hsp) |
0.0 |
2810 |
46% |
|
- Product
- AmphJ
- Gene
- amphJ
- Organism
- Streptomyces nodosus
|
1uniprot[Pubmed] 11451671 [Medline] 21344785 Amphotericin biosynthesis in Streptomyces nodosus: deductions from analysis of polyketide synthase and late genes.(Chem. Biol.) [2001] | 2uniprot[Pubmed] 16079135 Biosynthesis of amphotericin derivatives lacking exocyclic carboxyl groups.(J. Biol. Chem.) [2005] | [pubmed all]
|
84
|
B5M9L2_STRLS (B5M9L2) |
|
(6 hsp) |
0.0 |
2788 |
47% |
|
- Product
- Lasalocid modular polyketide synthase
Putative polyketide synthase
- Gene
- lasAV
lsd15
- Organism
- Streptomyces lasaliensis
|
1uniprot[Pubmed] 19129623 Identification of a gene cluster of polyether antibiotic lasalocid from Streptomyces lasaliensis.(Biosci. Biotechnol. Biochem.) [2009] | 2uniprot[Pubmed] 18710235 Epoxide hydrolase Lsd19 for polyether formation in the biosynthesis of lasalocid A: direct experimental evidence on polyene-polyepoxide hypothesis in polyether biosynthesis.(J. Am. Chem. Soc.) [2008] | [pubmed all]
|
85
|
A4FH83_SACEN (A4FH83) |
|
(11 hsp) |
0.0 |
2787 |
49% |
|
- Product
- Type I modular polyketide synthase
- Gene
- SACE_4139
- Organism
- Saccharopolyspora erythraea (strain NRRL 23338)
|
1uniprot[Pubmed] 17369815 Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007] |
|
86
|
Q5VKR4_SACER (Q5VKR4) |
|
(11 hsp) |
0.0 |
2787 |
49% |
|
- Product
- Type I PKS
- Gene
- pkeAIII
- Organism
- Saccharopolyspora erythraea
Streptomyces erythraeus
|
1uniprot[Pubmed] 15925898 A new modular polyketide synthase in the erythromycin producer Saccharopolyspora erythraea.(J. Mol. Microbiol. Biotechnol.) [2004] |
|
88
|
A0ACI3_STRAM (A0ACI3) |
|
(11 hsp) |
0.0 |
2782 |
48% |
|
- Product
- Putative type I modular polyketide synthase
- Gene
- SAMR0477
- Organism
- Streptomyces ambofaciens ATCC 23877
|
1uniprot[Pubmed] 16956972 Evolution of the terminal regions of the Streptomyces linear chromosome.(Mol. Biol. Evol.) [2006] | 2uniprot Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877.(Microbiology (Mosc.)) [2006] |
|
91
|
Q93HJ3_STRAW (Q93HJ3) |
|
(9 hsp) |
0.0 |
2778 |
49% |
|
- Product
- Modular polyketide synthase
- Gene
- olmA3
SAV2897 SAV_2897
- Organism
- Streptomyces avermitilis
|
1uniprot[Pubmed] 11572948 [Medline] 21477403 Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.(Proc. Natl. Acad. Sci. U.S.A.) [2001] | 2uniprot[Pubmed] 12692562 [Medline] 22608306 Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis.(Nat. Biotechnol.) [2003] | [pubmed all]
|
92
|
Q9L4X2_9ACTO (Q9L4X2) |
|
(12 hsp) |
0.0 |
2743 |
48% |
|
- Product
- NysJ
- Gene
- nysJ
- Organism
- Streptomyces noursei
|
1uniprot[Pubmed] 10873841 [Medline] 20334850 Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: analysis of the gene cluster and deduction of the biosynthetic pathway.(Chem. Biol.) [2000] |
|
93
|
Q0R4M5_STRAT (Q0R4M5) |
|
(13 hsp) |
0.0 |
2714 |
48% |
|
- Product
- ChlA3
- Gene
-
- Organism
- Streptomyces antibioticus
|
1uniprot[Pubmed] 16793515 Genetic characterization of the chlorothricin gene cluster as a model for spirotetronate antibiotic biosynthesis.(Chem. Biol.) [2006] |
|
96
|
B2HNF5_MYCMM (B2HNF5) |
|
(11 hsp) |
0.0 |
2693 |
45% |
|
- Product
- Type I modular polyketide synthase
- Gene
- MMAR_3798
- Organism
- Mycobacterium marinum (strain ATCC BAA-535 / M)
|
1uniprot[Pubmed] 18403782 Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis.(Genome Res.) [2008] |
|
99
|
B6CLY8_9MYCO (B6CLY8) |
|
(26 hsp) |
0.0 |
2593 |
46% |
|
- Product
- Type I modular polyketide synthase, MlsA1
- Gene
- mlsA1
MULP_065
- Organism
- Mycobacterium liflandii 128FXT
|
1uniprot[Pubmed] 18840298 Deciphering the genetic basis for polyketide variation among mycobacteria producing mycolactones.(BMC Genomics) [2008] |
|
100
|
Q9KID7_STRHY (Q9KID7) |
|
(13 hsp) |
0.0 |
2580 |
48% |
|
- Product
- FkbA
- Gene
- fkbA
- Organism
- Streptomyces hygroscopicus subsp. ascomyceticus
|
1uniprot[Pubmed] 10863099 [Medline] 20323220 The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units.(Gene) [2000] |
|