BLAST table : Heda_00110

DB	UniProtKB

	accession	Evalue	Score	Ident.	link	product	gene	organism	ec
1	Q67G47_9ACTO (Q67G47)	1e-133	479	100%	UniProt GenBank	Putative N,N-dimethyltransferase		Streptomyces griseoruber
2	D1A6T9_THECD (D1A6T9)	1e-78	296	62%	UniProt GenBank	Methyltransferase type 12	Tcur_2798	Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
3	O54260_STRNO (O54260)	5e-70	268	57%	UniProt GenBank	SnogX	snogX	Streptomyces nogalater
4	E8RWU8_MICSL (E8RWU8)	2e-66	256	55%	UniProt GenBank	Methyltransferase type 12	ML5_4437	Micromonospora sp. (strain L5)
5	D9T281_MICAI (D9T281)	3e-66	255	55%	UniProt GenBank	Methyltransferase type 11	Micau_3984	Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
6	Q8KRX6_9ACTO (Q8KRX6)	8e-63	244	54%	UniProt GenBank	NbmE	nbmE	Streptomyces narbonensis
7	Q54529_9ACTO (Q54529)	8e-63	244	54%	UniProt GenBank	RdmD	rdmD	Streptomyces purpurascens
8	Q0PY17_STRMY (Q0PY17)	1e-62	243	52%	UniProt GenBank	N-methyltransferase	midK	Streptomyces mycarofaciens
9	A8Y8F7_STRAM (A8Y8F7)	1e-60	237	53%	UniProt GenBank	Probable NDP-aminohexose N-dimethyltransferase	srm1*c	Streptomyces ambofaciens
10	E8RWU3_MICSL (E8RWU3)	2e-60	236	50%	UniProt GenBank	Methyltransferase type 11	ML5_4432	Micromonospora sp. (strain L5)
11	Q9ZGH6_9ACTO (Q9ZGH6)	2e-60	236	52%	UniProt GenBank	N,N-dimethyltransferase	desVI	Streptomyces venezuelae
12	D9T286_MICAI (D9T286)	3e-60	236	50%	UniProt GenBank	Methyltransferase type 11	Micau_3989	Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
13	Q83WE2_MICGR (Q83WE2)	3e-60	235	51%	UniProt GenBank	N, N-dimethyltransferase	mydG	Micromonospora griseorubida
14	A8WDM8_9ACTO (A8WDM8)	3e-59	233	50%	UniProt GenBank	N-methyltransferase		Streptomyces eurythermus
15	P95748_STRFR (P95748)	9e-59	231	51%	UniProt GenBank	N-methyltransferase	tylMI(orf3*)	Streptomyces fradiae Streptomyces roseoflavus
16	O87832_STRAT (O87832)	1e-58	231	51%	UniProt GenBank	Methyltransferase	oleM1	Streptomyces antibioticus
17	Q8VWA4_9ACTO (Q8VWA4)	1e-58	230	52%	UniProt GenBank	AclP	aclP	Streptomyces galilaeus
18	Q5Y9G1_9ACTO (Q5Y9G1)	4e-58	229	49%	UniProt GenBank	N-methyltransferase	eryCVI	Aeromicrobium erythreum
19	D1H0I7_9ACTO (D1H0I7)	8e-58	228	50%	UniProt GenBank	Putative N,N-dimethyltransferase	ravNMT	Streptomyces sp. C23201NS3
20	A4F7N5_SACEN (A4F7N5)	3e-57	226	50%	UniProt GenBank	TDP-desosamine-N-dimethyltransferase	eryCVI SACE_0718	Saccharopolyspora erythraea (strain NRRL 23338)
21	O33940_SACER (O33940)	3e-57	226	50%	UniProt GenBank	EryCVI Putative TDP-N-dimethyldesosamine-N-methyltransferase	eryCVI EryCVI	Saccharopolyspora erythraea Streptomyces erythraeus
22	D1A6S9_THECD (D1A6S9)	3e-57	225	50%	UniProt GenBank	Methyltransferase type 11	Tcur_2788	Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
23	A0ACH8_STRAM (A0ACH8)	2e-56	223	51%	UniProt GenBank	Putative TDP-N-dimethyldesosamine-N-methyltransferase	SAMR0472	Streptomyces ambofaciens ATCC 23877
24	B5G876_9ACTO (B5G876)	4e-56	222	54%	UniProt GenBank	Methyltransferase type 11	SSBG_00484	Streptomyces sp. SPB74
25	A8LZQ3_SALAI (A8LZQ3)	9e-56	221	47%	UniProt GenBank	Methyltransferase type 12	Sare_2049	Salinispora arenicola (strain CNS-205)
26	Q9F836_9ACTO (Q9F836)	9e-56	221	51%	UniProt GenBank	Daunosaminyl-N,N-dimethyltransferase	megDIII	Micromonospora megalomicea subsp. nigra
27	Q67G36_9ACTO (Q67G36)	4e-55	218	48%	UniProt GenBank	N,N-dimethyltransferase		Streptomyces griseoruber
28	Q7WT22_9ACTO (Q7WT22)	3e-54	216	54%	UniProt GenBank	N-methyl transferase	med-ORF15	Streptomyces sp. AM-7161
29	Q0H2X7_9ACTO (Q0H2X7)	1e-53	214	50%	UniProt GenBank	Putative aminomethylase	atS10	Actinomadura melliaura
30	Q9RN53_STRNO (Q9RN53)	3e-53	212	47%	UniProt GenBank	Putative amino methylase	snogA	Streptomyces nogalater
31	Q8KNF4_MICEC (Q8KNF4)	5e-53	211	45%	UniProt GenBank	CalS10	calS10	Micromonospora echinospora Micromonospora purpurea
32	Q9L4U1_9ACTO (Q9L4U1)	2e-52	210	43%	UniProt GenBank	Putative aminomethylase	aknX2	Streptomyces galilaeus
33	E1ARK0_STRAU (E1ARK0)	3e-52	209	47%	UniProt GenBank	Putative NDP-aminohexose N-dimethyltransferase	sa52	Streptomyces aureofaciens
34	B5G896_9ACTO (B5G896)	6e-51	205	42%	UniProt GenBank	Methyltransferase type 11	SSBG_00504	Streptomyces sp. SPB74
35	Q00510_STRAM (Q00510)	2e-50	203	47%	UniProt GenBank	Probable NDP-aminohexose N-dimethyltransferase SrmX	srm9c srmX	Streptomyces ambofaciens
36	Q2J5F9_FRASC (Q2J5F9)	5e-49	198	46%	UniProt GenBank	Methyltransferase type 11	Francci3_4135	Frankia sp. (strain CcI3)
37	Q8GMH8_STRGL (Q8GMH8)	9e-49	197	44%	UniProt GenBank	N-methyl transferase		Streptomyces globisporus
38	Q9ALP0_9PSEU (Q9ALP0)	1e-47	194	43%	UniProt GenBank	Probable N-dimethyltransferase	spnS	Saccharopolyspora spinosa
39	Q4JHQ0_9PSEU (Q4JHQ0)	3e-47	192	42%	UniProt GenBank	BusS	busS	Saccharopolyspora pogona
40	D5SLQ3_STRCL (D5SLQ3)	2e-44	183	45%	UniProt GenBank	Putative aminomethylase	SCLAV_p1362	Streptomyces clavuligerus ATCC 27064
41	C6WK00_ACTMD (C6WK00)	1e-42	177	46%	UniProt GenBank	Methyltransferase type 11	Amir_4362	Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971)
42	D9VC57_9ACTO (D9VC57)	6e-41	171	40%	UniProt GenBank	Putative uncharacterized protein	SSMG_03445	Streptomyces sp. AA4
43	A1YZ58_9ACTO (A1YZ58)	8e-39	164	45%	UniProt GenBank	PdmO	pdmO	Actinomadura hibisca
44	E5DUG6_9NOCA (E5DUG6)	2e-36	156	39%	UniProt GenBank	NocS2	nocS2	Nocardia sp. ATCC 202099
45	Q76KZ2_STRHA (Q76KZ2)	7e-36	155	40%	UniProt GenBank	N-methyltransferase	vinG	Streptomyces halstedii
46	O30769_9ACTO (O30769)	2e-34	150	53%	UniProt GenBank	N-methyltransferase homolog		Streptomyces caelestis
47	D7B030_NOCDD (D7B030)	8e-34	148	41%	UniProt GenBank	Methyltransferase type 11	Ndas_4732	Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488) Actinomadura dassonvillei
48	D6GX12_9EURY (D6GX12)	8e-34	148	33%	UniProt GenBank	Methyltransferase type 11	BJBARM5_1036	Candidatus Parvarchaeum acidophilus ARMAN-5
49	D6AT94_STRFL (D6AT94)	1e-33	147	39%	UniProt GenBank	N-methyltransferase	SSGG_05538	Streptomyces roseosporus NRRL 15998
50	D3EL41_GEOS4 (D3EL41)	2e-33	146	38%	UniProt GenBank	Methyltransferase type 12	GYMC10_3744	Geobacillus sp. (strain Y412MC10)
51	B5JL16_9BACT (B5JL16)	1e-27	127	36%	UniProt GenBank	Methyltransferase domain family	VDG1235_1133	Verrucomicrobiae bacterium DG1235
52	D7BG71_MEISD (D7BG71)	5e-25	119	47%	UniProt GenBank	Methyltransferase type 12	Mesil_0044	Meiothermus silvanus (strain ATCC 700542 / DSM 9946 / VI-R2) Thermus silvanus
53	F0TCW0_METSL (F0TCW0)	2e-23	114	32%	UniProt GenBank	Methyltransferase type 12	Metbo_2286	Methanobacterium sp. (strain AL-21)
54	F6D3J1_9EURY (F6D3J1)	5e-22	108	33%	UniProt GenBank	Methyltransferase type 11	MSWAN_0365	Methanobacterium sp. SWAN-1
55	D8NNC6_RALSO (D8NNC6)	1e-21	107	33%	UniProt GenBank	Putative N,N-dimethyltransferase	RCFBP_20777	Ralstonia solanacearum Pseudomonas solanacearum
56	E6W5A8_DESIS (E6W5A8)	2e-19	100	34%	UniProt GenBank	Methyltransferase type 11	Selin_2472	Desulfurispirillum indicum (strain ATCC BAA-1389 / S5)
57	C0EHP4_9CLOT (C0EHP4)	9e-18	95.1	31%	UniProt GenBank	Putative uncharacterized protein	CLOSTMETH_03389	Clostridium methylpentosum DSM 5476
58	E4VN82_9HELI (E4VN82)	1e-17	94.4	25%	UniProt GenBank	Methyltransferase type 11	HCCG_02116	Helicobacter cinaedi CCUG 18818
59	Q1JZZ3_DESAC (Q1JZZ3)	1e-17	94.4	31%	UniProt GenBank	Methyltransferase type 12	Dace_2449	Desulfuromonas acetoxidans DSM 684
60	B5EGU4_GEOBB (B5EGU4)	3e-16	90.1	33%	UniProt GenBank	SAM-dependent methyltransferase, type 11	Gbem_2569	Geobacter bemidjiensis (strain Bem / ATCC BAA-1014 / DSM 16622)
61	D8FZB9_9CYAN (D8FZB9)	3e-14	83.2	30%	UniProt GenBank	Methyltransferase type 11	OSCI_2320014	Oscillatoria sp. PCC 6506
62	C6JL20_FUSVA (C6JL20)	4e-14	82.8	28%	UniProt GenBank	S-adenosylmethionine-dependent methyltransferase	FVAG_02720	Fusobacterium varium ATCC 27725
63	B3EBP4_GEOLS (B3EBP4)	6e-14	82.4	29%	UniProt GenBank	Methyltransferase type 11	Glov_3377	Geobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ)
64	C4FIR8_9AQUI (C4FIR8)	9e-14	81.6	29%	UniProt GenBank	SAM-dependent methyltransferase	SULYE_0458	Sulfurihydrogenibium yellowstonense SS-5
65	C7Q3F3_CATAD (C7Q3F3)	3e-13	80.1	39%	UniProt GenBank	Methyltransferase type 12	Caci_6880	Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
66	C0CWX1_9CLOT (C0CWX1)	4e-13	79.3	28%	UniProt GenBank	Putative uncharacterized protein	CLOSTASPAR_01492	Clostridium asparagiforme DSM 15981
67	C3WEX4_FUSMR (C3WEX4)	1e-12	78.2	28%	UniProt GenBank	Putative uncharacterized protein	FMAG_01992	Fusobacterium mortiferum ATCC 9817
68	E5BY46_9FUSO (E5BY46)	1e-12	77.8	28%	UniProt GenBank	Putative uncharacterized protein	FUAG_02934	Fusobacterium ulcerans ATCC 49185
69	Q2LVN7_SYNAS (Q2LVN7)	2e-12	77	28%	UniProt GenBank	SAM-dependent methyltransferase	SYNAS_22660 SYN_00826	Syntrophus aciditrophicus (strain SB)
70	Q9RR75_DEIRA (Q9RR75)	3e-12	76.6	33%	UniProt GenBank	Putative uncharacterized protein	DR_2622	Deinococcus radiodurans
71	D3QCG2_STALH (D3QCG2)	5e-12	75.9	32%	UniProt GenBank	Methyltransferase	SLGD_01324	Staphylococcus lugdunensis (strain HKU09-01)
72	F8KJN3_STALU (F8KJN3)	5e-12	75.9	32%	UniProt GenBank	Putative uncharacterized protein	SLUG_13210	Staphylococcus lugdunensis
73	E6M742_STALU (E6M742)	5e-12	75.9	32%	UniProt GenBank	Methyltransferase	HMPREF0790_0217	Staphylococcus lugdunensis M23590	2.1.1.- niceE keggE
74	B1KLB2_SHEWM (B1KLB2)	9e-12	75.1	33%	UniProt GenBank	Methyltransferase type 11	Swoo_1549	Shewanella woodyi (strain ATCC 51908 / MS32)
75	C4RCS7_9ACTO (C4RCS7)	1e-11	74.7	35%	UniProt GenBank	Methyltransferase type 11	MCAG_00257	Micromonospora sp. ATCC 39149
76	Q4L6U2_STAHJ (Q4L6U2)	2e-11	73.9	28%	UniProt GenBank	Similar to ubiE/COQ5 methyltransferase family	SH1324	Staphylococcus haemolyticus (strain JCSC1435)
77	F6BJP8_9FIRM (F6BJP8)	4e-11	73.2	37%	UniProt GenBank	Methyltransferase type 12	Thexy_1976	Thermoanaerobacterium xylanolyticum LX-11
78	Q1Q1V2_9BACT (Q1Q1V2)	4e-11	72.8	25%	UniProt GenBank	Putative uncharacterized protein	kuste3229	Candidatus Kuenenia stuttgartiensis
79	C1ARK2_RHOOB (C1ARK2)	5e-11	72.8	37%	UniProt GenBank	Putative methyltransferase	ROP_04320	Rhodococcus opacus (strain B4)	2.1.1.- niceE keggE
80	C9YU18_STRSW (C9YU18)	6e-11	72.4	40%	UniProt GenBank	Putative methyltransferase	SCAB_81911	Streptomyces scabies (strain 87.22) Streptomyces scabiei
81	A3JFM6_9ALTE (A3JFM6)	7e-11	72	36%	UniProt GenBank	Putative uncharacterized protein	MELB17_06309	Marinobacter sp. ELB17
82	E5BHC9_9FUSO (E5BHC9)	8e-11	72	25%	UniProt GenBank	S-adenosylmethionine (SAM)-dependent methyltransferase	FSBG_01399	Fusobacterium sp. 3_1_5R
83	Q053E7_LEPBL (Q053E7)	8e-11	71.6	26%	UniProt GenBank	Methyltransferase	LBL_1018	Leptospira borgpetersenii serovar Hardjo-bovis (strain L550)
84	Q04RD2_LEPBJ (Q04RD2)	8e-11	71.6	26%	UniProt GenBank	Methyltransferase	LBJ_2032	Leptospira borgpetersenii serovar Hardjo-bovis (strain JB197)
85	E5C1M0_9FUSO (E5C1M0)	9e-11	71.6	25%	UniProt GenBank	S-adenosylmethionine (SAM)-dependent methyltransferase	FGAG_00964	Fusobacterium gonidiaformans ATCC 25563
86	Q1PUV5_9BACT (Q1PUV5)	1e-10	71.2	25%	UniProt GenBank	Putative uncharacterized protein	kustc0258	Candidatus Kuenenia stuttgartiensis
87	Q6GGB0_STAAR (Q6GGB0)	1e-10	71.2	33%	UniProt GenBank	Putative uncharacterized protein	SAR1668	Staphylococcus aureus (strain MRSA252)
88	E5QUV4_STAAH (E5QUV4)	1e-10	71.2	33%	UniProt GenBank	Methyltransferase	HMPREF0772_11550	Staphylococcus aureus (strain TCH60)	2.1.1.- niceE keggE
89	E5TAC7_STAAU (E5TAC7)	1e-10	71.2	33%	UniProt GenBank	Putative uncharacterized protein	CGSSa00_07480	Staphylococcus aureus subsp. aureus CGS00
90	D6SJ25_STAAU (D6SJ25)	1e-10	71.2	33%	UniProt GenBank	Methyltransferase	HMPREF0769_12089	Staphylococcus aureus subsp. aureus MN8	2.1.1.- niceE keggE
91	D6LYE9_STAAU (D6LYE9)	1e-10	71.2	33%	UniProt GenBank	Putative uncharacterized protein	SIAG_00696	Staphylococcus aureus subsp. aureus EMRSA16
92	D6J112_STAAU (D6J112)	1e-10	71.2	33%	UniProt GenBank	Putative uncharacterized protein	SAZG_01618	Staphylococcus aureus subsp. aureus M809
93	D6HHF2_STAAU (D6HHF2)	1e-10	71.2	33%	UniProt GenBank	Putative uncharacterized protein	SCAG_01993	Staphylococcus aureus subsp. aureus 58-424
94	D6H0F9_STAAU (D6H0F9)	1e-10	71.2	33%	UniProt GenBank	Putative methyltransferase	SAVG_02164	Staphylococcus aureus subsp. aureus M1015
95	D2USL0_STAAU (D2USL0)	1e-10	71.2	33%	UniProt GenBank	Putative methyltransferase	SHAG_01575	Staphylococcus aureus subsp. aureus A017934/97
96	D2GRZ2_STAAU (D2GRZ2)	1e-10	71.2	33%	UniProt GenBank	Putative methyltransferase	SFAG_01623	Staphylococcus aureus subsp. aureus C160
97	D2GGU5_STAAU (D2GGU5)	1e-10	71.2	33%	UniProt GenBank	Methyltransferase type 12	SDAG_01623	Staphylococcus aureus subsp. aureus Btn1260
98	D2G9Q8_STAAU (D2G9Q8)	1e-10	71.2	33%	UniProt GenBank	Methyltransferase type 12	SAYG_00230	Staphylococcus aureus subsp. aureus WW2703/97
99	D2G2F9_STAAU (D2G2F9)	1e-10	71.2	33%	UniProt GenBank	Methyltransferase type 12	SAXG_01229	Staphylococcus aureus subsp. aureus WBG10049
100	D2FVU7_STAAU (D2FVU7)	1e-10	71.2	33%	UniProt GenBank	Putative methyltransferase	SAWG_01607	Staphylococcus aureus subsp. aureus M899

accession

alignment

Evalue

Score

Ident.

link

information

pubmed

Q67G47_9ACTO
(Q67G47)

1e-133

479

100%

Product: Putative N,N-dimethyltransferase
Gene
Organism: Streptomyces griseoruber

1uniprot[Pubmed] 15271354
The hedamycin locus implicates a novel aromatic PKS priming mechanism.(Chem. Biol.) [2004]

D1A6T9_THECD
(D1A6T9)

1e-78

296

62%

Product: Methyltransferase type 12
Gene: Tcur_2798
Organism: Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)

1uniprot
Complete genome sequence of Thermomonospora curvata type strain (B9).(Stand. Genomic Sci.) [2011]

O54260_STRNO
(O54260)

5e-70

268

57%

Product: SnogX
Gene: snogX
Organism: Streptomyces nogalater

[pubmed all]
1uniprot[Pubmed] 8668120 [Medline] 96242142 A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.(Mol. Gen. Genet.) [1996]
2uniprot[Pubmed] 9349712 [Medline] 98007868 Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.(Mol. Gen. Genet.) [1997]
3uniprot[Pubmed] 8760909 [Medline] 96349102 Production of hybrid anthracycline antibiotics by heterologous expression of Streptomyces nogalater nogalamycin biosynthesis genes.(Microbiology) [1996]

Q54529_9ACTO
(Q54529)

8e-63

244

54%

Product: RdmD
Gene: rdmD
Organism: Streptomyces purpurascens

[pubmed all]
1uniprot[Pubmed] 7751313 [Medline] 95270621 Nucleotide sequences and expression of genes from Streptomyces purpurascens that cause the production of new anthracyclines in Streptomyces galilaeus.(J. Bacteriol.) [1995]
2uniprot[Pubmed] 8081500 [Medline] 94362902 Hybrid anthracycline antibiotics: production of new anthracyclines by cloned genes from Streptomyces purpurascens in Streptomyces galilaeus.(Microbiology) [1994]

Q0PY17_STRMY
(Q0PY17)

1e-62

243

52%

Product: N-methyltransferase
Gene: midK
Organism: Streptomyces mycarofaciens

1uniprot[Pubmed] 17342257
Cloning and characterization of genes encoded in dTDP-D-mycaminose biosynthetic pathway from a midecamycin-producing strain, Streptomyces mycarofaciens.(Acta Biochim. Biophys. Sin.) [2007]

A8Y8F7_STRAM
(A8Y8F7)

1e-60

237

53%

Product: Probable NDP-aminohexose N-dimethyltransferase
Gene: srm1*c
Organism: Streptomyces ambofaciens

1uniprot
Organization of the biosynthetic gene cluster for the macrolide antibiotic spiramycin in Streptomyces ambofaciens.(Microbiology (Mosc.)) [2007]

Q9ZGH6_9ACTO
(Q9ZGH6)

2e-60

236

52%

Product: N,N-dimethyltransferase
Gene: desVI
Organism: Streptomyces venezuelae

[pubmed all]
1uniprot[Pubmed] 9770448 [Medline] 98445333 A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity.(Proc. Natl. Acad. Sci. U.S.A.) [1998]
2uniprot[Pubmed] 18327916 Three-dimensional structure of DesVI from Streptomyces venezuelae: a sugar N,N-dimethyltransferase required for dTDP-desosamine biosynthesis.(Biochemistry) [2008]

Q83WE2_MICGR
(Q83WE2)

3e-60

235

51%

Product: N, N-dimethyltransferase
Gene: mydG
Organism: Micromonospora griseorubida

1uniprot[Pubmed] 12583909 [Medline] 22472038
Organization of the biosynthetic gene cluster for the polyketide macrolide mycinamicin in Micromonospora griseorubida.(FEMS Microbiol. Lett.) [2003]

P95748_STRFR
(P95748)

9e-59

231

51%

Product: N-methyltransferase
Gene: tylMI(orf3*)
Organism: Streptomyces fradiae
Streptomyces roseoflavus

[pubmed all]
1uniprot[Pubmed] 9031628 [Medline] 97183662 Analysis of four tylosin biosynthetic genes from the tylLM region of Streptomyces fradiae.(Gene) [1997]
2uniprot[Pubmed] 21142177 Molecular architecture of TylM1 from Streptomyces fradiae: an N,N-dimethyltransferase involved in the production of dTDP-D-mycaminose.(Biochemistry) [2011]

O87832_STRAT
(O87832)

1e-58

231

51%

Product: Methyltransferase
Gene: oleM1
Organism: Streptomyces antibioticus

1uniprot[Pubmed] 9749673 [Medline] 98420102
Analysis of a Streptomyces antibioticus chromosomal region involved in oleandomycin biosynthesis, which encodes two glycosyltransferases responsible for glycosylation of the macrolactone ring.(Mol. Gen. Genet.) [1998]

Q8VWA4_9ACTO
(Q8VWA4)

1e-58

230

52%

Product: AclP
Gene: aclP
Organism: Streptomyces galilaeus

1uniprot[Pubmed] 12399480 [Medline] 22286521
Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus.(J. Bacteriol.) [2002]

Q5Y9G1_9ACTO
(Q5Y9G1)

4e-58

229

49%

Product: N-methyltransferase
Gene: eryCVI
Organism: Aeromicrobium erythreum

1uniprot[Pubmed] 15257441
The erythromycin biosynthetic gene cluster of Aeromicrobium erythreum.(J. Ind. Microbiol. Biotechnol.) [2004]

A4F7N5_SACEN
(A4F7N5)

3e-57

226

50%

Product: TDP-desosamine-N-dimethyltransferase
Gene: eryCVI
SACE_0718
Organism: Saccharopolyspora erythraea (strain NRRL 23338)

1uniprot[Pubmed] 17369815
Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007]

O33940_SACER
(O33940)

3e-57

226

50%

Product: EryCVI
Putative TDP-N-dimethyldesosamine-N-methyltransferase
Gene: eryCVI
EryCVI
Organism: Saccharopolyspora erythraea
Streptomyces erythraeus

[pubmed all]
1uniprot[Pubmed] 9353926 [Medline] 98015410 Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production.(Microbiology)
2uniprot[Pubmed] 9393448 [Medline] 98055166 Analysis of seven genes from the eryAI-eryK region of the erythromycin biosynthetic gene cluster in Saccharopolyspora erythraea.(Mol. Gen. Genet.) [1997]

D1A6S9_THECD
(D1A6S9)

3e-57

225

50%

Product: Methyltransferase type 11
Gene: Tcur_2788
Organism: Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)

1uniprot
Complete genome sequence of Thermomonospora curvata type strain (B9).(Stand. Genomic Sci.) [2011]

A0ACH8_STRAM
(A0ACH8)

2e-56

223

51%

Product: Putative TDP-N-dimethyldesosamine-N-methyltransferase
Gene: SAMR0472
Organism: Streptomyces ambofaciens ATCC 23877

1uniprot[Pubmed] 16956972
Evolution of the terminal regions of the Streptomyces linear chromosome.(Mol. Biol. Evol.) [2006]

2uniprot
Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877.(Microbiology (Mosc.)) [2006]

Q9F836_9ACTO
(Q9F836)

9e-56

221

51%

Product: Daunosaminyl-N,N-dimethyltransferase
Gene: megDIII
Organism: Micromonospora megalomicea subsp. nigra

1uniprot[Pubmed] 10972798 [Medline] 20430101
Biosynthesis of the anti-parasitic agent megalomicin: transformation of erythromycin to megalomicin in Saccharopolyspora erythraea.(Mol. Microbiol.) [2000]

Q67G36_9ACTO
(Q67G36)

4e-55

218

48%

Product: N,N-dimethyltransferase
Gene
Organism: Streptomyces griseoruber

1uniprot[Pubmed] 15271354
The hedamycin locus implicates a novel aromatic PKS priming mechanism.(Chem. Biol.) [2004]

Q7WT22_9ACTO
(Q7WT22)

3e-54

216

54%

Product: N-methyl transferase
Gene: med-ORF15
Organism: Streptomyces sp. AM-7161

1uniprot
Cloning, sequencing and heterologous expression of the medermycin biosynthetic gene cluster of Streptomyces sp. AM-7161: towards comparative analysis of the benzoisochromanequione gene clusters.(Microbiology (Mosc.)) [2003]

Q0H2X7_9ACTO
(Q0H2X7)

1e-53

214

50%

Product: Putative aminomethylase
Gene: atS10
Organism: Actinomadura melliaura

1uniprot[Pubmed] 16873021
Deciphering indolocarbazole and enediyne aminodideoxypentose biosynthesis through comparative genomics: insights from the AT2433 biosynthetic locus.(Chem. Biol.) [2006]

Q9RN53_STRNO
(Q9RN53)

3e-53

212

47%

Product: Putative amino methylase
Gene: snogA
Organism: Streptomyces nogalater

[pubmed all]
1uniprot[Pubmed] 9349712 [Medline] 98007868 Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.(Mol. Gen. Genet.) [1997]
2uniprot[Pubmed] 10639368 [Medline] 20106987 Identification of a cyclase gene dictating the C-9 stereochemistry of anthracyclines from Streptomyces nogalater.(Antimicrob. Agents Chemother.) [2000]

Q8KNF4_MICEC
(Q8KNF4)

5e-53

211

45%

Product: CalS10
Gene: calS10
Organism: Micromonospora echinospora
Micromonospora purpurea

1uniprot[Pubmed] 12183629 [Medline] 22171414
The calicheamicin gene cluster and its iterative type I enediyne PKS.(Science) [2002]

Q9L4U1_9ACTO
(Q9L4U1)

2e-52

210

43%

Product: Putative aminomethylase
Gene: aknX2
Organism: Streptomyces galilaeus

1uniprot[Pubmed] 11016846 [Medline] 20469061
A gene cluster from Streptomyces galilaeus involved in glycosylation of aclarubicin.(Mol. Gen. Genet.) [2000]

E1ARK0_STRAU
(E1ARK0)

3e-52

209

47%

Product: Putative NDP-aminohexose N-dimethyltransferase
Gene: sa52
Organism: Streptomyces aureofaciens

1uniprot[Pubmed] 21393365
The role of two SARP family transcriptional regulators in regulation of the auricin gene cluster in Streptomyces aureofaciens CCM 3239.(Microbiology) [2011]

Q00510_STRAM
(Q00510)

2e-50

203

47%

Product: Probable NDP-aminohexose N-dimethyltransferase
SrmX
Gene: srm9c
srmX
Organism: Streptomyces ambofaciens

1uniprot[Pubmed] 1508047 [Medline] 92374852
Characterization of a novel regulatory gene governing the expression of a polyketide synthase gene in Streptomyces ambofaciens.(Mol. Microbiol.) [1992]

2uniprot
Organization of the biosynthetic gene cluster for the macrolide antibiotic spiramycin in Streptomyces ambofaciens.(Microbiology (Mosc.)) [2007]

Q2J5F9_FRASC
(Q2J5F9)

5e-49

198

46%

Product: Methyltransferase type 11
Gene: Francci3_4135
Organism: Frankia sp. (strain CcI3)

1uniprot[Pubmed] 17151343
Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007]

Q8GMH8_STRGL
(Q8GMH8)

9e-49

197

44%

Product: N-methyl transferase
Gene
Organism: Streptomyces globisporus

1uniprot[Pubmed] 12183628 [Medline] 22171413
Biosynthesis of the enediyne antitumor antibiotic C-1027.(Science) [2002]

Q9ALP0_9PSEU
(Q9ALP0)

1e-47

194

43%

Product: Probable N-dimethyltransferase
Gene: spnS
Organism: Saccharopolyspora spinosa

1uniprot[Pubmed] 11358695 [Medline] 21257765
Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa.(Chem. Biol.) [2001]

Q4JHQ0_9PSEU
(Q4JHQ0)

3e-47

192

42%

Product: BusS
Gene: busS
Organism: Saccharopolyspora pogona

1uniprot[Pubmed] 16179985
Butenyl-spinosyns, a natural example of genetic engineering of antibiotic biosynthetic genes.(J. Ind. Microbiol. Biotechnol.) [2006]

D5SLQ3_STRCL
(D5SLQ3)

2e-44

183

45%

Product: Putative aminomethylase
Gene: SCLAV_p1362
Organism: Streptomyces clavuligerus ATCC 27064

1uniprot
The sequence of a 1.8 Mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.(Genome Biol. Evol.) [2010]

C6WK00_ACTMD
(C6WK00)

1e-42

177

46%

Product: Methyltransferase type 11
Gene: Amir_4362
Organism: Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971)

1uniprot
Complete genome sequence of Actinosynnema mirum type strain (101).(Stand. Genomic Sci.) [2009]

E5DUG6_9NOCA
(E5DUG6)

2e-36

156

39%

Product: NocS2
Gene: nocS2
Organism: Nocardia sp. ATCC 202099

1uniprot[Pubmed] 20473441
Moving posttranslational modifications forward to biosynthesize the glycosylated thiopeptide nocathiacin I in Nocardia sp. ATCC202099.(Mol. Biosyst.) [2010]

Q76KZ2_STRHA
(Q76KZ2)

7e-36

155

40%

Product: N-methyltransferase
Gene: vinG
Organism: Streptomyces halstedii

1uniprot[Pubmed] 15112997
Cloning, sequencing, and functional analysis of the biosynthetic gene cluster of macrolactam antibiotic vicenistatin in Streptomyces halstedii.(Chem. Biol.) [2004]

O30769_9ACTO
(O30769)

2e-34

150

53%

Product: N-methyltransferase homolog
Gene
Organism: Streptomyces caelestis

1uniprot[Pubmed] 9393718 [Medline] 98053867
Identification and characterization of the niddamycin polyketide synthase genes from Streptomyces caelestis.(J. Bacteriol.) [1997]

D7B030_NOCDD
(D7B030)

8e-34

148

41%

Product: Methyltransferase type 11
Gene: Ndas_4732
Organism: Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei

1uniprot
Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010]

D6GX12_9EURY
(D6GX12)

8e-34

148

33%

Product: Methyltransferase type 11
Gene: BJBARM5_1036
Organism: Candidatus Parvarchaeum acidophilus ARMAN-5

1uniprot[Pubmed] 20421484
Enigmatic, ultrasmall, uncultivated Archaea.(Proc. Natl. Acad. Sci. U.S.A.) [2010]

D7BG71_MEISD
(D7BG71)

5e-25

119

47%

Product: Methyltransferase type 12
Gene: Mesil_0044
Organism: Meiothermus silvanus (strain ATCC 700542 / DSM 9946 / VI-R2)
Thermus silvanus

1uniprot
Complete genome sequence of Meiothermus silvanus type strain (VI-R2T).(Stand. Genomic Sci.) [2010]

D8NNC6_RALSO
(D8NNC6)

1e-21

107

33%

Product: Putative N,N-dimethyltransferase
Gene: RCFBP_20777
Organism: Ralstonia solanacearum
Pseudomonas solanacearum

1uniprot
Genomes of three tomato pathogens within the Ralstonia solanacearum species complex reveal significant evolutionary divergence.(BMC Genomics) [2010]

D8FZB9_9CYAN
(D8FZB9)

3e-14

83.2

30%

Product: Methyltransferase type 11
Gene: OSCI_2320014
Organism: Oscillatoria sp. PCC 6506

1uniprot
The Genome Sequence of the Cyanobacterium Oscillatoria sp. PCC 6506 Reveals Several Gene Clusters Responsible for the Biosynthesis of Toxins and Secondary Metabolites.(J. Bacteriol.) [2010]

C7Q3F3_CATAD
(C7Q3F3)

3e-13

80.1

39%

Product: Methyltransferase type 12
Gene: Caci_6880
Organism: Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)

1uniprot
Complete genome sequence of Catenulispora acidiphila type strain (ID 139908).(Stand. Genomic Sci.) [2009]

Q9RR75_DEIRA
(Q9RR75)

3e-12

76.6

33%

Product: Putative uncharacterized protein
Gene: DR_2622
Organism: Deinococcus radiodurans

1uniprot[Pubmed] 10567266 [Medline] 20036896
Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1.(Science) [1999]

D3QCG2_STALH
(D3QCG2)

5e-12

75.9

32%

Product: Methyltransferase
Gene: SLGD_01324
Organism: Staphylococcus lugdunensis (strain HKU09-01)

1uniprot[Pubmed] 20047907
Complete genome sequence of Staphylococcus lugdunensis strain HKU09-01.(J. Bacteriol.) [2010]

Q4L6U2_STAHJ
(Q4L6U2)

2e-11

73.9

28%

Product: Similar to ubiE/COQ5 methyltransferase family
Gene: SH1324
Organism: Staphylococcus haemolyticus (strain JCSC1435)

1uniprot[Pubmed] 16237012
Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species.(J. Bacteriol.) [2005]

Q1Q1V2_9BACT
(Q1Q1V2)

4e-11

72.8

25%

Product: Putative uncharacterized protein
Gene: kuste3229
Organism: Candidatus Kuenenia stuttgartiensis

1uniprot[Pubmed] 16598256
Deciphering the evolution and metabolism of an anammox bacterium from a community genome.(Nature) [2006]

C9YU18_STRSW
(C9YU18)

6e-11

72.4

40%

Product: Putative methyltransferase
Gene: SCAB_81911
Organism: Streptomyces scabies (strain 87.22)
Streptomyces scabiei

1uniprot[Pubmed] 20064060
Streptomyces scabies 87-22 contains a coronafacic acid-like biosynthetic cluster that contributes to plant-microbe interactions.(Mol. Plant Microbe Interact.) [2010]

Q053E7_LEPBL
(Q053E7)

8e-11

71.6

26%

Product: Methyltransferase
Gene: LBL_1018
Organism: Leptospira borgpetersenii serovar Hardjo-bovis (strain L550)

1uniprot[Pubmed] 16973745
Genome reduction in Leptospira borgpetersenii reflects limited transmission potential.(Proc. Natl. Acad. Sci. U.S.A.) [2006]

Q04RD2_LEPBJ
(Q04RD2)

8e-11

71.6

26%

Product: Methyltransferase
Gene: LBJ_2032
Organism: Leptospira borgpetersenii serovar Hardjo-bovis (strain JB197)

1uniprot[Pubmed] 16973745
Genome reduction in Leptospira borgpetersenii reflects limited transmission potential.(Proc. Natl. Acad. Sci. U.S.A.) [2006]

Q1PUV5_9BACT
(Q1PUV5)

1e-10

71.2

25%

Product: Putative uncharacterized protein
Gene: kustc0258
Organism: Candidatus Kuenenia stuttgartiensis

1uniprot[Pubmed] 16598256
Deciphering the evolution and metabolism of an anammox bacterium from a community genome.(Nature) [2006]

Q6GGB0_STAAR
(Q6GGB0)

1e-10

71.2

33%

Product: Putative uncharacterized protein
Gene: SAR1668
Organism: Staphylococcus aureus (strain MRSA252)

1uniprot[Pubmed] 15213324
Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance.(Proc. Natl. Acad. Sci. U.S.A.) [2004]