BLAST table : Medem_00260

DB	UniProtKB

	accession	Evalue	Score	Ident.	link	product	gene	organism
1	Q7WT16_9ACTO (Q7WT16)	3e-80	301	100%	UniProt GenBank	Putative uncharacterized protein med-ORF10	med-ORF10	Streptomyces sp. AM-7161
2	Q2J5J0_FRASC (Q2J5J0)	3e-52	207	68%	UniProt GenBank	Aromatic-ring-hydroxylating dioxygenase, beta subunit	Francci3_4104	Frankia sp. (strain CcI3)
3	Q9ZA28_STRVN (Q9ZA28)	3e-36	155	55%	UniProt GenBank	Gra-orf31 protein	gra-orf31	Streptomyces violaceoruber
4	E3T4B5_9ACTO (E3T4B5)	5e-36	154	54%	UniProt GenBank	Putative uncharacterized protein	gra-orf31	Streptomyces vietnamensis
5	D3U1V2_9BACT (D3U1V2)	1e-35	153	55%	UniProt GenBank	ActVI-A like		uncultured soil bacterium V167
6	E3J3P6_FRASU (E3J3P6)	2e-34	148	56%	UniProt GenBank	Aromatic-ring-hydroxylating dioxygenase beta subunit	FraEuI1c_1316	Frankia sp. (strain EuI1c)
7	D9W5A3_9ACTO (D9W5A3)	2e-33	145	56%	UniProt GenBank	DNA-binding protein	SSNG_07333	Streptomyces sp. C
8	Q53925_STRCO (Q53925)	8e-32	140	51%	UniProt GenBank	Hydroxylacyl-CoA dehydrogenase	ORFA SCO5071	Streptomyces coelicolor
9	D6EWC3_STRLI (D6EWC3)	1e-31	139	51%	UniProt GenBank	Hydroxylacyl-CoA dehydrogenase	SSPG_02618	Streptomyces lividans TK24
10	C7PWR4_CATAD (C7PWR4)	3e-31	138	55%	UniProt GenBank	Aromatic-ring-hydroxylating dioxygenase beta subunit	Caci_6494	Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
11	Q54278_SACHI (Q54278)	1e-28	129	52%	UniProt GenBank	DNA-binding protein		Saccharopolyspora hirsuta
12	D9UBS1_STRPR (D9UBS1)	2e-28	129	47%	UniProt GenBank	Putative aromatase	cpp13	Streptomyces pristinaespiralis
13	B5HIV3_STRPR (B5HIV3)	2e-28	129	47%	UniProt GenBank	Aromatic-ring-hydroxylating dioxygenase	SSDG_05090	Streptomyces pristinaespiralis ATCC 25486
14	Q54997_9ACTO (Q54997)	3e-27	125	52%	UniProt GenBank	ActVI-ORFA homolog	frnO	Streptomyces roseofulvus
15	B2HGM9_MYCMM (B2HGM9)	1e-21	106	42%	UniProt GenBank	Putative uncharacterized protein	MMAR_1563	Mycobacterium marinum (strain ATCC BAA-535 / M)
16	C0JWC8_9ACTO (C0JWC8)	9e-20	100	45%	UniProt GenBank	PokC1	pokC1	Streptomyces diastatochromogenes
17	B8Y4H2_STRAU (B8Y4H2)	5e-16	87.8	42%	UniProt GenBank	Putative cyclase	sa16	Streptomyces aureofaciens
18	B8Y4G8_STRAU (B8Y4G8)	3e-15	85.5	38%	UniProt GenBank	Putative cyclase	sa12	Streptomyces aureofaciens
19	Q70J90_STRGR (Q70J90)	3e-15	85.1	41%	UniProt GenBank	Cyclase	cmmX	Streptomyces griseus subsp. griseus
20	Q3S8Q7_STRRM (Q3S8Q7)	7e-14	80.9	39%	UniProt GenBank	OxyI	oxyI	Streptomyces rimosus
21	Q4R0M5_STRCX (Q4R0M5)	7e-14	80.9	39%	UniProt GenBank	Putative uncharacterized protein chaN	chaN	Streptomyces chartreusis
22	B6SEE8_9ACTO (B6SEE8)	1e-13	80.1	37%	UniProt GenBank	Aln2	aln2	Streptomyces sp. CM020
23	D7BZR6_STRBB (D7BZR6)	1e-13	79.7	36%	UniProt GenBank	Hydroxylacyl-CoA dehydrogenase	SBI_06851	Streptomyces bingchenggensis (strain BCW-1)
24	B5G899_9ACTO (B5G899)	1e-13	79.7	41%	UniProt GenBank	Hydroxylacyl-CoA dehydrogenase	SSBG_00507	Streptomyces sp. SPB74
25	Q53670_STRAA (Q53670)	2e-13	79	38%	UniProt GenBank	Cyclase	mtmX	Streptomyces argillaceus
26	D6MSU8_9ACTO (D6MSU8)	2e-13	79	39%	UniProt GenBank	SsfY4	ssfY4	Streptomyces sp. SF2575
27	Q2J5F3_FRASC (Q2J5F3)	1e-12	76.3	38%	UniProt GenBank	Hydroxylacyl-CoA dehydrogenase	Francci3_4141	Frankia sp. (strain CcI3)
28	Q9RN65_STRNO (Q9RN65)	1e-12	76.3	41%	UniProt GenBank	SnoO	snoO	Streptomyces nogalater
29	Q9L4U3_9ACTO (Q9L4U3)	2e-12	75.9	38%	UniProt GenBank	AknV	aknV	Streptomyces galilaeus
30	A1C176_9ACTO (A1C176)	3e-12	75.5	35%	UniProt GenBank	Aromatase		Streptomyces echinatus
31	B2D1N8_9ACTO (B2D1N8)	3e-12	75.1	52%	UniProt GenBank	Frenolicin biosynthetic protein		Streptomyces sp. WXC
32	E8W954_STRFA (E8W954)	5e-12	74.7	38%	UniProt GenBank	Nuclear transport factor 2	Sfla_5320	Streptomyces flavogriseus (strain ATCC 33331 / DSM 40990 / IAF-45CD)
33	Q53879_STRS5 (Q53879)	5e-12	74.7	37%	UniProt GenBank	Putative uncharacterized protein		Streptomyces sp. (strain C5)
34	D1A615_THECD (D1A615)	2e-11	72.8	39%	UniProt GenBank	Putative uncharacterized protein	Tcur_2764	Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
35	Q8VWB6_9ACTO (Q8VWB6)	2e-11	72.4	37%	UniProt GenBank	AknE1	aknE1	Streptomyces galilaeus
36	E1ARK7_STRAU (E1ARK7)	3e-11	72.4	37%	UniProt GenBank	Putative cyclase	sa45	Streptomyces aureofaciens
37	Q9ZAT9_STRPE (Q9ZAT9)	3e-11	72	35%	UniProt GenBank	Daunorubicin biosynthesis enzyme	dpsH	Streptomyces peucetius
38	Q935Z5_9ACTO (Q935Z5)	4e-11	71.2	38%	UniProt GenBank	RdmK	rdmK	Streptomyces purpurascens
39	Q9L554_9ACTO (Q9L554)	5e-11	71.2	37%	UniProt GenBank	AknE1	aknE1	Streptomyces galilaeus
40	F3Z6S7_9ACTO (F3Z6S7)	1e-10	70.1	54%	UniProt GenBank	Putative ORFX	STTU_0694	Streptomyces sp. Tu6071
41	E8SDG1_MICSL (E8SDG1)	2e-10	69.3	36%	UniProt GenBank	Nuclear transport factor 2	ML5_4399	Micromonospora sp. (strain L5)
42	D9T2B9_MICAI (D9T2B9)	2e-10	69.3	36%	UniProt GenBank	Nuclear transport factor 2	Micau_4022	Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
43	Q2PA04_9ACTO (Q2PA04)	5e-09	64.7	35%	UniProt GenBank	Cyclase	stfX	Streptomyces steffisburgensis
44	Q9KHL2_9ACTO (Q9KHL2)	7e-09	63.9	34%	UniProt GenBank	EncG	encG	Streptomyces maritimus
45	B5G889_9ACTO (B5G889)	2e-08	62.8	34%	UniProt GenBank	Granaticin polyketide synthase bifunctional cyclase/dehydratase	SSBG_00497	Streptomyces sp. SPB74
46	D9UKN6_9ACTO (D9UKN6)	3e-07	58.9	48%	UniProt GenBank	Aromatic-ring-hydroxylating dioxygenase	SSLG_05752	Streptomyces sp. SPB78
47	F4CM68_9PSEU (F4CM68)	0.0002	49.3	36%	UniProt GenBank	Putative uncharacterized protein	Psed_0485	Pseudonocardia dioxanivorans CB1190

accession

alignment

Evalue

Score

Ident.

link

information

pubmed

Q7WT16_9ACTO
(Q7WT16)

3e-80

301

100%

Product: Putative uncharacterized protein med-ORF10
Gene: med-ORF10
Organism: Streptomyces sp. AM-7161

1uniprot
Cloning, sequencing and heterologous expression of the medermycin biosynthetic gene cluster of Streptomyces sp. AM-7161: towards comparative analysis of the benzoisochromanequione gene clusters.(Microbiology (Mosc.)) [2003]

Q2J5J0_FRASC
(Q2J5J0)

3e-52

207

68%

Product: Aromatic-ring-hydroxylating dioxygenase, beta subunit
Gene: Francci3_4104
Organism: Frankia sp. (strain CcI3)

1uniprot[Pubmed] 17151343
Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007]

Q9ZA28_STRVN
(Q9ZA28)

3e-36

155

55%

Product: Gra-orf31 protein
Gene: gra-orf31
Organism: Streptomyces violaceoruber

[pubmed all]
1uniprot[Pubmed] 2583128 [Medline] 90060034 Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber Tu22.(EMBO J.) [1989]
2uniprot[Pubmed] 7476861 [Medline] 96027933 Identification of Streptomyces violaceoruber Tu22 genes involved in the biosynthesis of granaticin.(Mol. Gen. Genet.) [1995]
3uniprot[Pubmed] 9831526 [Medline] 99051446 The granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tu22: sequence analysis and expression in a heterologous host.(Chem. Biol.) [1998]

Q53925_STRCO
(Q53925)

8e-32

140

51%

Product: Hydroxylacyl-CoA dehydrogenase
Gene: ORFA
SCO5071
Organism: Streptomyces coelicolor

[pubmed all]
1uniprot[Pubmed] 12000953 [Medline] 21996410 Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).(Nature) [2002]
2uniprot[Pubmed] 7929165 [Medline] 95014254 DNA sequence and functions of the actVI region of the actinorhodin biosynthetic gene cluster of Streptomyces coelicolor A3(2).(J. Biol. Chem.) [1994]

C7PWR4_CATAD
(C7PWR4)

3e-31

138

55%

Product: Aromatic-ring-hydroxylating dioxygenase beta subunit
Gene: Caci_6494
Organism: Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)

1uniprot
Complete genome sequence of Catenulispora acidiphila type strain (ID 139908).(Stand. Genomic Sci.) [2009]

Q54278_SACHI
(Q54278)

1e-28

129

52%

Product: DNA-binding protein
Gene
Organism: Saccharopolyspora hirsuta

1uniprot[Pubmed] 8341260 [Medline] 93341453
Saccharopolyspora hirsuta 367 encodes clustered genes similar to ketoacyl synthase, ketoacyl reductase, acyl carrier protein, and biotin carboxyl carrier protein.(Mol. Gen. Genet.) [1993]

D9UBS1_STRPR
(D9UBS1)

2e-28

129

47%

Product: Putative aromatase
Gene: cpp13
Organism: Streptomyces pristinaespiralis

1uniprot[Pubmed] 21342465
Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011]

Q54997_9ACTO
(Q54997)

3e-27

125

52%

Product: ActVI-ORFA homolog
Gene: frnO
Organism: Streptomyces roseofulvus

1uniprot[Pubmed] 8181754 [Medline] 94237486
Cloning, sequencing and deduced functions of a cluster of Streptomyces genes probably encoding biosynthesis of the polyketide antibiotic frenolicin.(Gene) [1994]

B2HGM9_MYCMM
(B2HGM9)

1e-21

106

42%

Product: Putative uncharacterized protein
Gene: MMAR_1563
Organism: Mycobacterium marinum (strain ATCC BAA-535 / M)

1uniprot[Pubmed] 18403782
Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis.(Genome Res.) [2008]

C0JWC8_9ACTO
(C0JWC8)

9e-20

100

45%

Product: PokC1
Gene: pokC1
Organism: Streptomyces diastatochromogenes

1uniprot[Pubmed] 19266534
Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009]

B8Y4H2_STRAU
(B8Y4H2)

5e-16

87.8

42%

Product: Putative cyclase
Gene: sa16
Organism: Streptomyces aureofaciens

1uniprot[Pubmed] 20490753
Identification and characterization of an indigoidine-like gene for a blue pigment biosynthesis in Streptomyces aureofaciens CCM 3239.(Folia Microbiol. (Praha)) [2010]

B8Y4G8_STRAU
(B8Y4G8)

3e-15

85.5

38%

Product: Putative cyclase
Gene: sa12
Organism: Streptomyces aureofaciens

1uniprot[Pubmed] 20490753
Identification and characterization of an indigoidine-like gene for a blue pigment biosynthesis in Streptomyces aureofaciens CCM 3239.(Folia Microbiol. (Praha)) [2010]

Q3S8Q7_STRRM
(Q3S8Q7)

7e-14

80.9

39%

Product: OxyI
Gene: oxyI
Organism: Streptomyces rimosus

1uniprot[Pubmed] 16597959
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.(Appl. Environ. Microbiol.) [2006]

Q4R0M5_STRCX
(Q4R0M5)

7e-14

80.9

39%

Product: Putative uncharacterized protein chaN
Gene: chaN
Organism: Streptomyces chartreusis

1uniprot[Pubmed] 15911378
Biosynthesis of the antitumor agent chartreusin involves the oxidative rearrangement of an anthracyclic polyketide.(Chem. Biol.) [2005]

B6SEE8_9ACTO
(B6SEE8)

1e-13

80.1

37%

Product: Aln2
Gene: aln2
Organism: Streptomyces sp. CM020

1uniprot[Pubmed] 18940666
Characterization of the alnumycin gene cluster reveals unusual gene products for pyran ring formation and dioxan biosynthesis.(Chem. Biol.) [2008]

D7BZR6_STRBB
(D7BZR6)

1e-13

79.7

36%

Product: Hydroxylacyl-CoA dehydrogenase
Gene: SBI_06851
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

Q53670_STRAA
(Q53670)

2e-13

38%

Product: Cyclase
Gene: mtmX
Organism: Streptomyces argillaceus

[pubmed all]
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]

D6MSU8_9ACTO
(D6MSU8)

2e-13

39%

Product: SsfY4
Gene: ssfY4
Organism: Streptomyces sp. SF2575

1uniprot[Pubmed] 19908837
Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.(J. Am. Chem. Soc.) [2009]

Q2J5F3_FRASC
(Q2J5F3)

1e-12

76.3

38%

Product: Hydroxylacyl-CoA dehydrogenase
Gene: Francci3_4141
Organism: Frankia sp. (strain CcI3)

1uniprot[Pubmed] 17151343
Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007]

Q9RN65_STRNO
(Q9RN65)

1e-12

76.3

41%

Product: SnoO
Gene: snoO
Organism: Streptomyces nogalater

[pubmed all]
1uniprot[Pubmed] 9349712 [Medline] 98007868 Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.(Mol. Gen. Genet.) [1997]
2uniprot[Pubmed] 10639368 [Medline] 20106987 Identification of a cyclase gene dictating the C-9 stereochemistry of anthracyclines from Streptomyces nogalater.(Antimicrob. Agents Chemother.) [2000]

Q9L4U3_9ACTO
(Q9L4U3)

2e-12

75.9

38%

Product: AknV
Gene: aknV
Organism: Streptomyces galilaeus

1uniprot[Pubmed] 11016846 [Medline] 20469061
A gene cluster from Streptomyces galilaeus involved in glycosylation of aclarubicin.(Mol. Gen. Genet.) [2000]

Q53879_STRS5
(Q53879)

5e-12

74.7

37%

Product: Putative uncharacterized protein
Gene
Organism: Streptomyces sp. (strain C5)

1uniprot[Pubmed] 8655529 [Medline] 96236066
Cloning, sequencing, and analysis of aklaviketone reductase from Streptomyces sp. strain C5.(J. Bacteriol.) [1996]

D1A615_THECD
(D1A615)

2e-11

72.8

39%

Product: Putative uncharacterized protein
Gene: Tcur_2764
Organism: Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)

1uniprot
Complete genome sequence of Thermomonospora curvata type strain (B9).(Stand. Genomic Sci.) [2011]

Q8VWB6_9ACTO
(Q8VWB6)

2e-11

72.4

37%

Product: AknE1
Gene: aknE1
Organism: Streptomyces galilaeus

1uniprot[Pubmed] 12399480 [Medline] 22286521
Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus.(J. Bacteriol.) [2002]

E1ARK7_STRAU
(E1ARK7)

3e-11

72.4

37%

Product: Putative cyclase
Gene: sa45
Organism: Streptomyces aureofaciens

1uniprot[Pubmed] 21393365
The role of two SARP family transcriptional regulators in regulation of the auricin gene cluster in Streptomyces aureofaciens CCM 3239.(Microbiology) [2011]

Q9ZAT9_STRPE
(Q9ZAT9)

3e-11

35%

Product: Daunorubicin biosynthesis enzyme
Gene: dpsH
Organism: Streptomyces peucetius

[pubmed all]
1uniprot[Pubmed] 8955419 [Medline] 97113559 Enhanced antibiotic production by manipulation of the Streptomyces peucetius dnrH and dnmT genes involved in doxorubicin (adriamycin) biosynthesis.(J. Bacteriol.) [1996]
2uniprot[Pubmed] 9864344 [Medline] 99084971 Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene.(J. Bacteriol.) [1999]

Q9L554_9ACTO
(Q9L554)

5e-11

71.2

37%

Product: AknE1
Gene: aknE1
Organism: Streptomyces galilaeus

1uniprot[Pubmed] 12137949 [Medline] 22133312
Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster.(Gene) [2002]

Q2PA04_9ACTO
(Q2PA04)

5e-09

64.7

35%

Product: Cyclase
Gene: stfX
Organism: Streptomyces steffisburgensis

1uniprot[Pubmed] 16751529
Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin.(Appl. Environ. Microbiol.) [2006]

Q9KHL2_9ACTO
(Q9KHL2)

7e-09

63.9

34%

Product: EncG
Gene: encG
Organism: Streptomyces maritimus

[pubmed all]
1uniprot Natural Metabolic Diversity Encoded by the Enterocin Biosynthesis Gene Cluster.(J. Am. Chem. Soc.) [2000]
2uniprot[Pubmed] 11137817 [Medline] 20579517 Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate 'Streptomyces maritimus': evidence for the derailment of an aromatic polyketide synthase.(Chem. Biol.) [2000]
3uniprot[Pubmed] 11948863 [Medline] 21942282 A mechanism of benzoic acid biosynthesis in plants and bacteria that mirrors fatty acid beta-oxidation.(Chembiochem) [2001]