| accession | DB | alignment | Evalue | Score | Ident. | link | information | pubmed |
1
|
Q7WT14_9ACTO (Q7WT14) |
|
|
0.0 |
734 |
100% |
|
- Product
- C-glycosyl transferase
- Gene
- med-ORF8
- Organism
- Streptomyces sp. AM-7161
|
1uniprot Cloning, sequencing and heterologous expression of the medermycin biosynthetic gene cluster of Streptomyces sp. AM-7161: towards comparative analysis of the benzoisochromanequione gene clusters.(Microbiology (Mosc.)) [2003] |
|
2
|
C4NYL6_9ACTO (C4NYL6) |
|
|
1e-105 |
386 |
57% |
|
- Product
- SaqGT5
- Gene
- saqGT5
- Organism
- Micromonospora sp. Tu 6368
|
1uniprot[Pubmed] 17497146 A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007] | 2uniprot[Pubmed] 19384899 Cloning and sequencing of the biosynthetic gene cluster for saquayamycin z and galtamycin B and the elucidation of the assembly of their saccharide chains.(Chembiochem) [2009] | [pubmed all]
|
3
|
Q2HR56_9ACTO (Q2HR56) |
|
|
1e-103 |
379 |
54% |
|
- Product
- Putative C-glycosyltransferase
- Gene
- schS7
- Organism
- Streptomyces sp. SCC 2136
|
1uniprot Angucyclines Sch 47554 and Sch 47555 from Streptomyces sp. SCC-2136: Cloning, Sequencing, and Characterization.(Mol. Cells) [2006] | 2uniprot Molecular cloning and characterization of biosynthetic genes cluster of Sch 47554 from Streptomyces sp. SCC 2136. [2004] |
|
4
|
Q9ZGC0_STRCY (Q9ZGC0) |
|
|
1e-101 |
371 |
56% |
|
- Product
- Glycosyl transferase homolog
- Gene
- lanGT2
- Organism
- Streptomyces cyanogenus
|
1uniprot[Pubmed] 9933932 [Medline] 99132695 Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin biosynthesis.(FEMS Microbiol. Lett.) [1999] |
|
5
|
Q9RPA7_STRFR (Q9RPA7) |
|
|
4e-91 |
339 |
50% |
|
- Product
- Glycosyl transferase
- Gene
- urdGT2
- Organism
- Streptomyces fradiae
Streptomyces roseoflavus
|
1uniprot[Pubmed] 10658661 [Medline] 20121748 Two new tailoring enzymes, a glycosyltransferase and an oxygenase, involved in biosynthesis of the angucycline antibiotic urdamycin A in Streptomyces fradiae Tu2717.(Microbiology) [2000] | 2uniprot[Pubmed] 17640665 Structure and action of the C-C bond-forming glycosyltransferase UrdGT2 involved in the biosynthesis of the antibiotic urdamycin.(J. Mol. Biol.) [2007] | [pubmed all]
|
8
|
Q9ZA43_STRVN (Q9ZA43) |
|
|
5e-83 |
313 |
46% |
|
- Product
- Putative glycosyl transferase
- Gene
- gra-orf14
- Organism
- Streptomyces violaceoruber
|
1uniprot[Pubmed] 2583128 [Medline] 90060034 Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber Tu22.(EMBO J.) [1989] | 2uniprot[Pubmed] 7476861 [Medline] 96027933 Identification of Streptomyces violaceoruber Tu22 genes involved in the biosynthesis of granaticin.(Mol. Gen. Genet.) [1995] | 3uniprot[Pubmed] 9831526 [Medline] 99051446 The granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tu22: sequence analysis and expression in a heterologous host.(Chem. Biol.) [1998] | [pubmed all]
|
11
|
D9UBQ7_STRPR (D9UBQ7) |
|
|
3e-78 |
296 |
51% |
|
- Product
- Putative glycosyltransferase
- Gene
- cpp27
- Organism
- Streptomyces pristinaespiralis
|
1uniprot[Pubmed] 21342465 Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011] |
|
14
|
D8HZA4_AMYMU (D8HZA4) |
|
|
2e-77 |
294 |
45% |
|
- Product
- DNTP-hexose glycosyl transferase
- Gene
- AMED_0639
- Organism
- Amycolatopsis mediterranei (strain U-32)
|
1uniprot[Pubmed] 20567260 Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010] |
|
15
|
O52563_AMYMD (O52563) |
|
|
2e-77 |
294 |
45% |
|
- Product
- Putative dNTP-hexose glycosyltransferase
- Gene
-
- Organism
- Amycolatopsis mediterranei
Nocardia mediterranei
|
1uniprot[Pubmed] 9512878 [Medline] 98174059 Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699.(Chem. Biol.) [1998] | 2uniprot[Pubmed] 9497318 [Medline] 98165773 3-amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the formation of the precursor of mC7N units in rifamycin and related antibiotics.(J. Biol. Chem.) [1998] | 3uniprot[Pubmed] 11278540 [Medline] 21201076 Mutational analysis and reconstituted expression of the biosynthetic genes involved in the formation of 3-amino-5-hydroxybenzoic acid, the starter unit of rifamycin biosynthesis in amycolatopsis Mediterranei S699.(J. Biol. Chem.) [2001] | [pubmed all]
|
17
|
D1A6R8_THECD (D1A6R8) |
|
|
9e-76 |
288 |
46% |
|
- Product
- Putative uncharacterized protein
- Gene
- Tcur_2776
- Organism
- Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
|
1uniprot Complete genome sequence of Thermomonospora curvata type strain (B9).(Stand. Genomic Sci.) [2011] |
|
18
|
Q67G44_9ACTO (Q67G44) |
|
|
1e-74 |
285 |
47% |
|
- Product
- Glycosyltransferase
- Gene
-
- Organism
- Streptomyces griseoruber
|
1uniprot[Pubmed] 15271354 The hedamycin locus implicates a novel aromatic PKS priming mechanism.(Chem. Biol.) [2004] |
|
21
|
Q56176_STRVN (Q56176) |
|
|
1e-59 |
235 |
44% |
|
- Product
- ORF5; putative
- Gene
-
- Organism
- Streptomyces violaceoruber
|
1uniprot[Pubmed] 7476861 [Medline] 96027933 Identification of Streptomyces violaceoruber Tu22 genes involved in the biosynthesis of granaticin.(Mol. Gen. Genet.) [1995] |
|
22
|
Q6QWC4_STRGL (Q6QWC4) |
|
|
2e-59 |
234 |
60% |
|
- Product
- Glycosyltransferase lndGT2
- Gene
-
- Organism
- Streptomyces globisporus
|
1uniprot[Pubmed] 15123249 Generation of new landomycins by combinatorial biosynthetic manipulation of the LndGT4 gene of the landomycin E cluster in S. globisporus.(Chem. Biol.) [2004] |
|
23
|
Q7X2H0_9ACTO (Q7X2H0) |
|
|
3e-59 |
233 |
36% |
|
- Product
- Putative C-glycosyltransferase
- Gene
- gilGT
- Organism
- Streptomyces griseoflavus
|
1uniprot[Pubmed] 12822997 [Medline] 22708304 The complete gene cluster of the antitumor agent gilvocarcin V and its implication for the biosynthesis of the gilvocarcins.(J. Am. Chem. Soc.) [2003] |
|
26
|
A8Y8I2_STRAM (A8Y8I2) |
|
|
6e-48 |
196 |
40% |
|
- Product
- Putative glycosyltransferase
- Gene
- srm18
- Organism
- Streptomyces ambofaciens
|
1uniprot Organization of the biosynthetic gene cluster for the macrolide antibiotic spiramycin in Streptomyces ambofaciens.(Microbiology (Mosc.)) [2007] |
|
27
|
D6MSX4_9ACTO (D6MSX4) |
|
|
8e-48 |
196 |
35% |
|
- Product
- SsfS6
- Gene
- ssfS6
- Organism
- Streptomyces sp. SF2575
|
1uniprot[Pubmed] 19908837 Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.(J. Am. Chem. Soc.) [2009] |
|
28
|
D1A6T1_THECD (D1A6T1) |
|
|
2e-47 |
194 |
39% |
|
- Product
- Putative uncharacterized protein
- Gene
- Tcur_2790
- Organism
- Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
|
1uniprot Complete genome sequence of Thermomonospora curvata type strain (B9).(Stand. Genomic Sci.) [2011] |
|
29
|
D8I4K4_AMYMU (D8I4K4) |
|
|
1e-43 |
182 |
35% |
|
- Product
- Putative glycosyl transferase
- Gene
- AMED_5418
- Organism
- Amycolatopsis mediterranei (strain U-32)
|
1uniprot[Pubmed] 20567260 Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010] |
|
30
|
Q4R0L9_STRCX (Q4R0L9) |
|
|
2e-43 |
181 |
37% |
|
- Product
- ChaGT1 protein
- Gene
- chaGT1
- Organism
- Streptomyces chartreusis
|
1uniprot[Pubmed] 15911378 Biosynthesis of the antitumor agent chartreusin involves the oxidative rearrangement of an anthracyclic polyketide.(Chem. Biol.) [2005] |
|
32
|
Q67G38_9ACTO (Q67G38) |
|
|
1e-40 |
172 |
37% |
|
- Product
- Glycosyltransferase
- Gene
-
- Organism
- Streptomyces griseoruber
|
1uniprot[Pubmed] 15271354 The hedamycin locus implicates a novel aromatic PKS priming mechanism.(Chem. Biol.) [2004] |
|
33
|
Q8GHC2_9ACTO (Q8GHC2) |
|
|
6e-38 |
163 |
37% |
|
- Product
- Glycosyltransferase
- Gene
- cloM
- Organism
- Streptomyces roseochromogenes subsp. oscitans
|
1uniprot[Pubmed] 12480894 [Medline] 22368916 Molecular cloning and sequence analysis of the clorobiocin biosynthetic gene cluster: new insights into the biosynthesis of aminocoumarin antibiotics.(Microbiology) [2002] |
|
34
|
Q9L9F5_STRSH (Q9L9F5) |
|
|
4e-36 |
156 |
36% |
|
- Product
- NovM
- Gene
- novM
- Organism
- Streptomyces spheroides
Streptomyces caeruleus
|
1uniprot[Pubmed] 10770754 [Medline] 20233587 Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891.(Antimicrob. Agents Chemother.) [2000] |
|
35
|
Q9F8U7_9ACTO (Q9F8U7) |
|
|
2e-35 |
154 |
36% |
|
- Product
- Glycosyl transferase
- Gene
- couM
- Organism
- Streptomyces rishiriensis
|
1uniprot[Pubmed] 11036020 [Medline] 20493109 Identification of the coumermycin A(1) biosynthetic gene cluster of Streptomyces rishiriensis DSM 40489.(Antimicrob. Agents Chemother.) [2000] |
|
36
|
Q9ZGB8_STRCY (Q9ZGB8) |
|
|
5e-35 |
153 |
34% |
|
- Product
- Glycosyl transferase homolog
- Gene
- lanGT1
- Organism
- Streptomyces cyanogenus
|
1uniprot[Pubmed] 9933932 [Medline] 99132695 Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin biosynthesis.(FEMS Microbiol. Lett.) [1999] |
|
37
|
A4FK43_SACEN (A4FK43) |
|
|
6e-34 |
149 |
34% |
|
- Product
- Putative glycosyl transferase, related to UDP-glucuronosyltransferase
- Gene
- iroB
SACE_5174
- Organism
- Saccharopolyspora erythraea (strain NRRL 23338)
|
1uniprot[Pubmed] 17369815 Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007] |
|
38
|
D8I4K0_AMYMU (D8I4K0) |
|
|
5e-33 |
146 |
35% |
|
- Product
- Putative glycosyl transferase
- Gene
- AMED_5414
- Organism
- Amycolatopsis mediterranei (strain U-32)
|
1uniprot[Pubmed] 20567260 Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010] |
|
39
|
Q194P6_STRAA (Q194P6) |
|
|
3e-32 |
144 |
36% |
|
- Product
- Glycosyltransferase
- Gene
- mtmGII
- Organism
- Streptomyces argillaceus
|
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996] | 2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996] | 3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997] | 4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998] | 5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999] | 6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999] | 7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000] | 8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001] | 9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003] | 10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999] | 11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002] | 12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000] | 13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000] | 14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002] | 15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003] | 16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996] | 17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004] | 18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997] | 19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005] | 20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000] | [pubmed all]
|
40
|
D8I4I4_AMYMU (D8I4I4) |
|
|
3e-32 |
144 |
31% |
|
- Product
- Putative glycosyl transferase
- Gene
- AMED_5398
- Organism
- Amycolatopsis mediterranei (strain U-32)
|
1uniprot[Pubmed] 20567260 Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010] |
|
41
|
Q2HR28_9ACTO (Q2HR28) |
|
|
4e-32 |
143 |
33% |
|
- Product
- Putative O-glycosyltransferase
- Gene
- schS9
- Organism
- Streptomyces sp. SCC 2136
|
1uniprot Angucyclines Sch 47554 and Sch 47555 from Streptomyces sp. SCC-2136: Cloning, Sequencing, and Characterization.(Mol. Cells) [2006] | 2uniprot Molecular cloning and characterization of biosynthetic genes cluster of Sch 47554 from Streptomyces sp. SCC 2136. [2004] |
|
42
|
D7BZS5_STRBB (D7BZS5) |
|
|
8e-32 |
142 |
33% |
|
- Product
- IroB
- Gene
- SBI_06860
- Organism
- Streptomyces bingchenggensis (strain BCW-1)
|
1uniprot[Pubmed] 20581206 Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010] |
|
43
|
B3TMN6_9ACTO (B3TMN6) |
|
|
8e-32 |
142 |
33% |
|
- Product
- Glycosyltransferase
- Gene
- KijA4
- Organism
- Actinomadura kijaniata
|
1uniprot[Pubmed] 17985890 Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007] |
|
44
|
C0JWA3_9ACTO (C0JWA3) |
|
|
8e-32 |
142 |
34% |
|
- Product
- PokGT1
- Gene
- pokGT1
- Organism
- Streptomyces diastatochromogenes
|
1uniprot[Pubmed] 19266534 Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009] |
|
45
|
Q194P9_STRAA (Q194P9) |
|
|
2e-31 |
141 |
34% |
|
- Product
- Glycosyltransferase
- Gene
- mtmGIII
- Organism
- Streptomyces argillaceus
|
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996] | 2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996] | 3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997] | 4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998] | 5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999] | 6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999] | 7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000] | 8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001] | 9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003] | 10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999] | 11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002] | 12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000] | 13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000] | 14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002] | 15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003] | 16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996] | 17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004] | 18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997] | 19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005] | 20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000] | [pubmed all]
|
46
|
B3TMP7_9ACTO (B3TMP7) |
|
|
2e-31 |
141 |
32% |
|
- Product
- Glycosyltransferase
- Gene
- KijC3
- Organism
- Actinomadura kijaniata
|
1uniprot[Pubmed] 17985890 Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007] |
|
47
|
C4NYL1_9ACTO (C4NYL1) |
|
|
6e-31 |
139 |
33% |
|
- Product
- SaqGT4
- Gene
- saqGT4
- Organism
- Micromonospora sp. Tu 6368
|
1uniprot[Pubmed] 17497146 A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007] | 2uniprot[Pubmed] 19384899 Cloning and sequencing of the biosynthetic gene cluster for saquayamycin z and galtamycin B and the elucidation of the assembly of their saccharide chains.(Chembiochem) [2009] | [pubmed all]
|
48
|
A4GV85_9ACTO (A4GV85) |
|
|
8e-31 |
139 |
32% |
|
- Product
- Glycosyltransferase
- Gene
- holC
- Organism
- Streptomyces rufochromogenes
|
1uniprot[Pubmed] 17497146 A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007] |
|
49
|
D7BZS3_STRBB (D7BZS3) |
|
|
1e-30 |
139 |
32% |
|
- Product
- Glycosyl transferase, NDP-D-desosamine: 3-L-mycarosyl erythronolide B
- Gene
- SBI_06858
- Organism
- Streptomyces bingchenggensis (strain BCW-1)
|
1uniprot[Pubmed] 20581206 Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010] |
|
50
|
C4NYL0_9ACTO (C4NYL0) |
|
|
1e-30 |
138 |
35% |
|
- Product
- SaqGT3
- Gene
- saqGT3
- Organism
- Micromonospora sp. Tu 6368
|
1uniprot[Pubmed] 17497146 A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007] | 2uniprot[Pubmed] 19384899 Cloning and sequencing of the biosynthetic gene cluster for saquayamycin z and galtamycin B and the elucidation of the assembly of their saccharide chains.(Chembiochem) [2009] | [pubmed all]
|
51
|
C4NCL8_9ACTO (C4NCL8) |
|
|
2e-30 |
138 |
34% |
|
- Product
- Rhamnosyltransferase
- Gene
- cpz31
- Organism
- Streptomyces sp. MK730-62F2
|
1uniprot[Pubmed] 19351877 Identification and manipulation of the caprazamycin gene cluster leads to new simplified liponucleoside antibiotics and gives insights into the biosynthetic pathway.(J. Biol. Chem.) [2009] |
|
52
|
Q8FIW3_ECOL6 (Q8FIW3) |
|
|
5e-30 |
136 |
30% |
|
- Product
- Putative glucosyltransferase
- Gene
- iroB
c1254
- Organism
- Escherichia coli O6
|
1uniprot[Pubmed] 12471157 [Medline] 22388234 Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli.(Proc. Natl. Acad. Sci. U.S.A.) [2002] |
|
53
|
E1PH77_ECOAB (E1PH77) |
|
|
6e-30 |
136 |
30% |
|
- Product
- Putative glucosyltransferase
- Gene
- iroB
ECABU_c12110
- Organism
- Escherichia coli OR:K5:H- (strain ABU 83972)
|
1uniprot[Pubmed] 20865122 Host imprints on bacterial genomes--rapid, divergent evolution in individual patients.(PLoS Pathog.) [2010] |
|
54
|
Q6KD92_ECOLX (Q6KD92) |
|
|
6e-30 |
136 |
30% |
|
- Product
- IroB protein
- Gene
- iroB
- Organism
- Escherichia coli
|
1uniprot[Pubmed] 15292145 Analysis of the genome structure of the nonpathogenic probiotic Escherichia coli strain Nissle 1917.(J. Bacteriol.) [2004] |
|
57
|
O87831_STRAT (O87831) |
|
|
9e-30 |
135 |
30% |
|
- Product
- Glycosyltransferase
- Gene
- oleG2
- Organism
- Streptomyces antibioticus
|
1uniprot[Pubmed] 9749673 [Medline] 98420102 Analysis of a Streptomyces antibioticus chromosomal region involved in oleandomycin biosynthesis, which encodes two glycosyltransferases responsible for glycosylation of the macrolactone ring.(Mol. Gen. Genet.) [1998] |
|
58
|
Q6U5X7_KLEPN (Q6U5X7) |
|
|
2e-29 |
134 |
30% |
|
- Product
- IroB
- Gene
- iroB
LV240
- Organism
- Klebsiella pneumoniae
|
1uniprot[Pubmed] 15276215 Sequencing and analysis of the large virulence plasmid pLVPK of Klebsiella pneumoniae CG43.(Gene) [2004] |
|
59
|
C4XCY8_KLEPN (C4XCY8) |
|
|
2e-29 |
134 |
30% |
|
- Product
- Putative glucosyltransferase
- Gene
- iroB
KP1_p028
- Organism
- Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044
|
1uniprot[Pubmed] 19447910 Genome sequencing and comparative analysis of Klebsiella pneumoniae NTUH-K2044, a strain causing liver abscess and meningitis.(J. Bacteriol.) [2009] |
|
61
|
Q0TL40_ECOL5 (Q0TL40) |
|
|
2e-29 |
134 |
30% |
|
- Product
- Putative glycosyl transferase
- Gene
- ECP_0306
- Organism
- Escherichia coli O6:K15:H31 (strain 536 / UPEC)
|
1uniprot[Pubmed] 16879640 Role of pathogenicity island-associated integrases in the genome plasticity of uropathogenic Escherichia coli strain 536.(Mol. Microbiol.) [2006] |
|
62
|
D5CZL2_ECOKI (D5CZL2) |
|
|
2e-29 |
134 |
30% |
|
- Product
- IroB protein
- Gene
- ECOK1_1111
- Organism
- Escherichia coli O18:K1:H7 (strain IHE3034 / ExPEC)
|
1uniprot[Pubmed] 20439758 Identification of protective and broadly conserved vaccine antigens from the genome of extraintestinal pathogenic Escherichia coli.(Proc. Natl. Acad. Sci. U.S.A.) [2010] |
|
63
|
Q83WA1_ECOLX (Q83WA1) |
|
|
2e-29 |
134 |
30% |
|
- Product
- IroB protein
- Gene
- iroB
- Organism
- Escherichia coli
|
1uniprot[Pubmed] 11401961 [Medline] 21295072 S-fimbria-encoding determinant sfa(I) is located on pathogenicity island III(536) of uropathogenic Escherichia coli strain 536.(Infect. Immun.) [2001] | 2uniprot[Pubmed] 12379716 [Medline] 22267134 Genetic structure and distribution of four pathogenicity islands (PAI I(536) to PAI IV(536)) of uropathogenic Escherichia coli strain 536.(Infect. Immun.) [2002] | [pubmed all]
|
68
|
E4PEC8_ECO8N (E4PEC8) |
|
|
4e-29 |
133 |
29% |
|
- Product
- Salmochelin siderophore glycosyltransferase IroB
- Gene
- iroB
NRG857_30008
- Organism
- Escherichia coli O83:H1 (strain NRG 857C / AIEC)
|
1uniprot[Pubmed] 21108814 Genome sequence of adherent-invasive Escherichia coli and comparative genomic analysis with other E. coli pathotypes.(BMC Genomics) [2010] |
|
69
|
E1RUN0_ECOUM (E1RUN0) |
|
|
4e-29 |
133 |
29% |
|
- Product
- Salmochelin siderophore glycosyltransferase IroB
- Gene
- UM146_12295
- Organism
- Escherichia coli (strain UM146)
|
1uniprot[Pubmed] 21075930 Complete genome sequence of adherent invasive Escherichia coli UM146 isolated from ileal Crohn's disease biopsy tissue.(J. Bacteriol.) [2011] |
|
70
|
B7LIC3_ECO45 (B7LIC3) |
|
|
4e-29 |
133 |
29% |
|
- Product
- IroB, putative glucosyltransferase
- Gene
- iroB
pECS88_0128
- Organism
- Escherichia coli O45:K1 (strain S88 / ExPEC)
|
1uniprot[Pubmed] 19165319 Organised genome dynamics in the Escherichia coli species results in highly diverse adaptive paths.(PLoS Genet.) [2009] |
|
71
|
Q8GH22_ECOLX (Q8GH22) |
|
|
4e-29 |
133 |
29% |
|
- Product
- IroB
IroB, glycosyltransferase
- Gene
- iroB
MM1_0009
- Organism
- Escherichia coli
|
1uniprot[Pubmed] 12506201 [Medline] 22406310 Identification of pathogen-specific and conserved genes expressed in vivo by an avian pathogenic Escherichia coli strain.(Proc. Natl. Acad. Sci. U.S.A.) [2003] | 2uniprot[Pubmed] 19202093 The conserved portion of the putative virulence region contributes to virulence of avian pathogenic Escherichia coli.(Microbiology) [2009] | 3uniprot[Pubmed] 19156210 Full sequence and comparative analysis of the plasmid pAPEC-1 of avian pathogenic E. coli chi7122 (O78:K80:H9).(PLoS ONE) [2009] | 4uniprot[Pubmed] 12761110 [Medline] 22646068 Characterization of an iroBCDEN gene cluster on a transmissible plasmid of uropathogenic Escherichia coli: evidence for horizontal transfer of a chromosomal virulence factor.(Infect. Immun.) [2003] | [pubmed all]
|
81
|
Q27T80_ECOK1 (Q27T80) |
|
|
4e-29 |
133 |
29% |
|
- Product
- IroB
- Gene
- iroB
Ecok1_ColBM_46410 APECO1_O1CoBM141 O1_ColBM_141
- Organism
- Escherichia coli O1:K1 / APEC
|
1uniprot[Pubmed] 16885466 Complete DNA sequence of a ColBM plasmid from avian pathogenic Escherichia coli suggests that it evolved from closely related ColV virulence plasmids.(J. Bacteriol.) [2006] |
|
82
|
Q1RDF8_ECOUT (Q1RDF8) |
|
|
4e-29 |
133 |
29% |
|
- Product
- Putative glucosyltransferase
- Gene
- iroB
UTI89_C1122
- Organism
- Escherichia coli (strain UTI89 / UPEC)
|
1uniprot[Pubmed] 16585510 Identification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach.(Proc. Natl. Acad. Sci. U.S.A.) [2006] |
|
83
|
Q6Q1Q0_ECOLX (Q6Q1Q0) |
|
|
4e-29 |
133 |
29% |
|
- Product
- IroB
Salmochelin siderophore glycosyltransferase IroB
- Gene
- iroB
O2ColV53 pO103_42
- Organism
- Escherichia coli
|
1uniprot[Pubmed] 16954398 Acquisition of avian pathogenic Escherichia coli plasmids by a commensal E. coli isolate enhances its abilities to kill chicken embryos, grow in human urine, and colonize the murine kidney.(Infect. Immun.) [2006] | 2uniprot[Pubmed] 20160015 Sequence analysis and characterization of a transferable hybrid plasmid encoding multidrug resistance and enabling zoonotic potential for extraintestinal Escherichia coli.(Infect. Immun.) [2010] | [pubmed all]
|
85
|
B4TLN1_SALET (B4TLN1) |
|
|
4e-29 |
133 |
29% |
|
- Product
- IroB
- Gene
- SeKA_D0174
- Organism
- Salmonella enterica subsp. enterica serovar Kentucky str. CVM29188
|
1uniprot[Pubmed] 19648374 Antimicrobial resistance-conferring plasmids with similarity to virulence plasmids from avian pathogenic Escherichia coli strains in Salmonella enterica serovar Kentucky isolates from poultry.(Appl. Environ. Microbiol.) [2009] |
|
86
|
Q32HL4_SHIDS (Q32HL4) |
|
|
7e-29 |
133 |
29% |
|
- Product
- Putative glycosyl transferase
- Gene
- iroB
SDY_1026
- Organism
- Shigella dysenteriae serotype 1 (strain Sd197)
|
1uniprot[Pubmed] 16275786 Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery.(Nucleic Acids Res.) [2005] |
|
91
|
B3TMP5_9ACTO (B3TMP5) |
|
|
2e-28 |
131 |
34% |
|
- Product
- Glycosyltransferase
- Gene
- KijC1
- Organism
- Actinomadura kijaniata
|
1uniprot[Pubmed] 17985890 Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007] |
|
92
|
A4GV89_9ACTO (A4GV89) |
|
|
2e-28 |
131 |
32% |
|
- Product
- Glycosyltransferase
- Gene
- holN
- Organism
- Streptomyces sp. FU107
|
1uniprot[Pubmed] 17497146 A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007] |
|
93
|
D7B014_NOCDD (D7B014) |
|
|
4e-28 |
130 |
31% |
|
- Product
- Putative uncharacterized protein
- Gene
- Ndas_4716
- Organism
- Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei
|
1uniprot Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010] |
|
94
|
C4XAP2_KLEPN (C4XAP2) |
|
|
5e-28 |
130 |
30% |
|
- Product
- Putative UDP-glucoronosyl and UDP-glucosyl transferase
- Gene
- iroB
KP1_3611
- Organism
- Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044
|
1uniprot[Pubmed] 19447910 Genome sequencing and comparative analysis of Klebsiella pneumoniae NTUH-K2044, a strain causing liver abscess and meningitis.(J. Bacteriol.) [2009] |
|
95
|
A4GZE8_KLEPN (A4GZE8) |
|
|
5e-28 |
130 |
30% |
|
- Product
- IroB
- Gene
- iroB
- Organism
- Klebsiella pneumoniae
|
1uniprot[Pubmed] 17981959 Characterization of integrative and conjugative element ICEKp1-associated genomic heterogeneity in a Klebsiella pneumoniae strain isolated from a primary liver abscess.(J. Bacteriol.) [2008] |
|
97
|
D1GLU2_9ACTO (D1GLU2) |
|
|
5e-28 |
130 |
31% |
|
- Product
- Glycosyltransferase
- Gene
- slgG
- Organism
- Streptomyces lydicus
|
1uniprot Deciphering biosynthesis of the RNA polymerase inhibitor streptolydigin and generation of glycosylated derivatives.(Chem. Biol.) [2009] |
|
98
|
D7BZR5_STRBB (D7BZR5) |
|
|
5e-28 |
130 |
32% |
|
- Product
- Glycosyl transferase, NDP-D-desosamine: 3-L-mycarosyl erythronolide B
- Gene
- SBI_06850
- Organism
- Streptomyces bingchenggensis (strain BCW-1)
|
1uniprot[Pubmed] 20581206 Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010] |
|
100
|
C0JWA0_9ACTO (C0JWA0) |
|
|
6e-28 |
129 |
35% |
|
- Product
- PokGT2
- Gene
- pokGT2
- Organism
- Streptomyces diastatochromogenes
|
1uniprot[Pubmed] 19266534 Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009] |
|