| accession | DB | alignment | Evalue | Score | Ident. | link | information | pubmed |
1
|
Q53670_STRAA (Q53670) |
|
|
3e-81 |
304 |
100% |
|
- Product
- Cyclase
- Gene
- mtmX
- Organism
- Streptomyces argillaceus
|
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996] | 2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996] | 3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997] | 4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998] | 5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999] | 6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999] | 7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000] | 8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001] | 9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003] | 10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999] | 11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002] | 12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000] | 13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000] | 14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002] | 15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003] | 16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996] | 17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004] | 18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997] | 19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005] | 20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000] | [pubmed all]
|
2
|
Q9L4U3_9ACTO (Q9L4U3) |
|
|
5e-31 |
137 |
51% |
|
- Product
- AknV
- Gene
- aknV
- Organism
- Streptomyces galilaeus
|
1uniprot[Pubmed] 11016846 [Medline] 20469061 A gene cluster from Streptomyces galilaeus involved in glycosylation of aclarubicin.(Mol. Gen. Genet.) [2000] |
|
3
|
C0JWC8_9ACTO (C0JWC8) |
|
|
4e-30 |
134 |
50% |
|
- Product
- PokC1
- Gene
- pokC1
- Organism
- Streptomyces diastatochromogenes
|
1uniprot[Pubmed] 19266534 Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009] |
|
7
|
Q2PA04_9ACTO (Q2PA04) |
|
|
1e-28 |
129 |
49% |
|
- Product
- Cyclase
- Gene
- stfX
- Organism
- Streptomyces steffisburgensis
|
1uniprot[Pubmed] 16751529 Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin.(Appl. Environ. Microbiol.) [2006] |
|
8
|
Q9RN65_STRNO (Q9RN65) |
|
|
8e-28 |
127 |
53% |
|
- Product
- SnoO
- Gene
- snoO
- Organism
- Streptomyces nogalater
|
1uniprot[Pubmed] 9349712 [Medline] 98007868 Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.(Mol. Gen. Genet.) [1997] | 2uniprot[Pubmed] 10639368 [Medline] 20106987 Identification of a cyclase gene dictating the C-9 stereochemistry of anthracyclines from Streptomyces nogalater.(Antimicrob. Agents Chemother.) [2000] | [pubmed all]
|
10
|
D7BZR6_STRBB (D7BZR6) |
|
|
1e-25 |
119 |
47% |
|
- Product
- Hydroxylacyl-CoA dehydrogenase
- Gene
- SBI_06851
- Organism
- Streptomyces bingchenggensis (strain BCW-1)
|
1uniprot[Pubmed] 20581206 Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010] |
|
11
|
Q3S8Q7_STRRM (Q3S8Q7) |
|
|
8e-25 |
117 |
49% |
|
- Product
- OxyI
- Gene
- oxyI
- Organism
- Streptomyces rimosus
|
1uniprot[Pubmed] 16597959 Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.(Appl. Environ. Microbiol.) [2006] |
|
12
|
Q4R0M5_STRCX (Q4R0M5) |
|
|
1e-23 |
112 |
47% |
|
- Product
- Putative uncharacterized protein chaN
- Gene
- chaN
- Organism
- Streptomyces chartreusis
|
1uniprot[Pubmed] 15911378 Biosynthesis of the antitumor agent chartreusin involves the oxidative rearrangement of an anthracyclic polyketide.(Chem. Biol.) [2005] |
|
13
|
D6MSU8_9ACTO (D6MSU8) |
|
|
8e-23 |
110 |
46% |
|
- Product
- SsfY4
- Gene
- ssfY4
- Organism
- Streptomyces sp. SF2575
|
1uniprot[Pubmed] 19908837 Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.(J. Am. Chem. Soc.) [2009] |
|
15
|
Q9KHL2_9ACTO (Q9KHL2) |
|
|
4e-22 |
108 |
38% |
|
- Product
- EncG
- Gene
- encG
- Organism
- Streptomyces maritimus
|
1uniprot Natural Metabolic Diversity Encoded by the Enterocin Biosynthesis Gene Cluster.(J. Am. Chem. Soc.) [2000] | 2uniprot[Pubmed] 11137817 [Medline] 20579517 Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate 'Streptomyces maritimus': evidence for the derailment of an aromatic polyketide synthase.(Chem. Biol.) [2000] | 3uniprot[Pubmed] 11948863 [Medline] 21942282 A mechanism of benzoic acid biosynthesis in plants and bacteria that mirrors fatty acid beta-oxidation.(Chembiochem) [2001] | [pubmed all]
|
18
|
B8Y4H2_STRAU (B8Y4H2) |
|
|
5e-20 |
100 |
42% |
|
- Product
- Putative cyclase
- Gene
- sa16
- Organism
- Streptomyces aureofaciens
|
1uniprot[Pubmed] 20490753 Identification and characterization of an indigoidine-like gene for a blue pigment biosynthesis in Streptomyces aureofaciens CCM 3239.(Folia Microbiol. (Praha)) [2010] |
|
19
|
E1ARK7_STRAU (E1ARK7) |
|
|
9e-20 |
100 |
44% |
|
- Product
- Putative cyclase
- Gene
- sa45
- Organism
- Streptomyces aureofaciens
|
1uniprot[Pubmed] 21393365 The role of two SARP family transcriptional regulators in regulation of the auricin gene cluster in Streptomyces aureofaciens CCM 3239.(Microbiology) [2011] |
|
20
|
Q2J5F3_FRASC (Q2J5F3) |
|
|
2e-19 |
99.4 |
38% |
|
- Product
- Hydroxylacyl-CoA dehydrogenase
- Gene
- Francci3_4141
- Organism
- Frankia sp. (strain CcI3)
|
1uniprot[Pubmed] 17151343 Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007] |
|
21
|
B8Y4G8_STRAU (B8Y4G8) |
|
|
7e-19 |
97.4 |
40% |
|
- Product
- Putative cyclase
- Gene
- sa12
- Organism
- Streptomyces aureofaciens
|
1uniprot[Pubmed] 20490753 Identification and characterization of an indigoidine-like gene for a blue pigment biosynthesis in Streptomyces aureofaciens CCM 3239.(Folia Microbiol. (Praha)) [2010] |
|
22
|
Q53879_STRS5 (Q53879) |
|
|
3e-18 |
95.5 |
43% |
|
- Product
- Putative uncharacterized protein
- Gene
-
- Organism
- Streptomyces sp. (strain C5)
|
1uniprot[Pubmed] 8655529 [Medline] 96236066 Cloning, sequencing, and analysis of aklaviketone reductase from Streptomyces sp. strain C5.(J. Bacteriol.) [1996] |
|
23
|
E4WAC6_RHOE1 (E4WAC6) |
|
|
3e-17 |
91.7 |
42% |
|
- Product
- Putative uncharacterized protein
- Gene
- REQ_44380
- Organism
- Rhodococcus equi (strain 103S)
Corynebacterium equi
|
1uniprot[Pubmed] 20941392 The genome of a pathogenic rhodococcus: cooptive virulence underpinned by key gene acquisitions.(PLoS Genet.) [2010] |
|
25
|
Q9ZAT9_STRPE (Q9ZAT9) |
|
|
4e-16 |
88.2 |
42% |
|
- Product
- Daunorubicin biosynthesis enzyme
- Gene
- dpsH
- Organism
- Streptomyces peucetius
|
1uniprot[Pubmed] 8955419 [Medline] 97113559 Enhanced antibiotic production by manipulation of the Streptomyces peucetius dnrH and dnmT genes involved in doxorubicin (adriamycin) biosynthesis.(J. Bacteriol.) [1996] | 2uniprot[Pubmed] 9864344 [Medline] 99084971 Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene.(J. Bacteriol.) [1999] | [pubmed all]
|
26
|
D9UBS1_STRPR (D9UBS1) |
|
|
5e-16 |
87.8 |
38% |
|
- Product
- Putative aromatase
- Gene
- cpp13
- Organism
- Streptomyces pristinaespiralis
|
1uniprot[Pubmed] 21342465 Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011] |
|
29
|
D7AZ66_NOCDD (D7AZ66) |
|
|
1e-14 |
83.2 |
40% |
|
- Product
- Aromatic-ring-hydroxylating dioxygenase beta subunit
- Gene
- Ndas_4660
- Organism
- Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei
|
1uniprot Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010] |
|
30
|
Q9ZA28_STRVN (Q9ZA28) |
|
|
2e-14 |
82.4 |
37% |
|
- Product
- Gra-orf31 protein
- Gene
- gra-orf31
- Organism
- Streptomyces violaceoruber
|
1uniprot[Pubmed] 2583128 [Medline] 90060034 Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber Tu22.(EMBO J.) [1989] | 2uniprot[Pubmed] 7476861 [Medline] 96027933 Identification of Streptomyces violaceoruber Tu22 genes involved in the biosynthesis of granaticin.(Mol. Gen. Genet.) [1995] | 3uniprot[Pubmed] 9831526 [Medline] 99051446 The granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tu22: sequence analysis and expression in a heterologous host.(Chem. Biol.) [1998] | [pubmed all]
|
33
|
B2HGM9_MYCMM (B2HGM9) |
|
|
1e-13 |
80.1 |
35% |
|
- Product
- Putative uncharacterized protein
- Gene
- MMAR_1563
- Organism
- Mycobacterium marinum (strain ATCC BAA-535 / M)
|
1uniprot[Pubmed] 18403782 Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis.(Genome Res.) [2008] |
|
34
|
Q9L554_9ACTO (Q9L554) |
|
|
1e-13 |
79.7 |
42% |
|
- Product
- AknE1
- Gene
- aknE1
- Organism
- Streptomyces galilaeus
|
1uniprot[Pubmed] 12137949 [Medline] 22133312 Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster.(Gene) [2002] |
|
35
|
Q7WT16_9ACTO (Q7WT16) |
|
|
2e-13 |
79 |
38% |
|
- Product
- Putative uncharacterized protein med-ORF10
- Gene
- med-ORF10
- Organism
- Streptomyces sp. AM-7161
|
1uniprot Cloning, sequencing and heterologous expression of the medermycin biosynthetic gene cluster of Streptomyces sp. AM-7161: towards comparative analysis of the benzoisochromanequione gene clusters.(Microbiology (Mosc.)) [2003] |
|
36
|
Q8VWB6_9ACTO (Q8VWB6) |
|
|
8e-13 |
77.4 |
42% |
|
- Product
- AknE1
- Gene
- aknE1
- Organism
- Streptomyces galilaeus
|
1uniprot[Pubmed] 12399480 [Medline] 22286521 Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus.(J. Bacteriol.) [2002] |
|
38
|
Q2J5J0_FRASC (Q2J5J0) |
|
|
9e-13 |
77 |
42% |
|
- Product
- Aromatic-ring-hydroxylating dioxygenase, beta subunit
- Gene
- Francci3_4104
- Organism
- Frankia sp. (strain CcI3)
|
1uniprot[Pubmed] 17151343 Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007] |
|
44
|
Q2J5F8_FRASC (Q2J5F8) |
|
|
4e-10 |
68.2 |
38% |
|
- Product
- Putative uncharacterized protein
- Gene
- Francci3_4136
- Organism
- Frankia sp. (strain CcI3)
|
1uniprot[Pubmed] 17151343 Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007] |
|
45
|
C0ZPG5_RHOE4 (C0ZPG5) |
|
|
5e-10 |
67.8 |
34% |
|
- Product
- Putative uncharacterized protein
- Gene
- RER_49530
- Organism
- Rhodococcus erythropolis (strain PR4 / NBRC 100887)
|
1uniprot Sequence analysis of three plasmids harboured in Rhodococcus erythropolis strain PR4.(Environ. Microbiol.) [2006] |
|
47
|
Q54278_SACHI (Q54278) |
|
|
2e-09 |
65.9 |
37% |
|
- Product
- DNA-binding protein
- Gene
-
- Organism
- Saccharopolyspora hirsuta
|
1uniprot[Pubmed] 8341260 [Medline] 93341453 Saccharopolyspora hirsuta 367 encodes clustered genes similar to ketoacyl synthase, ketoacyl reductase, acyl carrier protein, and biotin carboxyl carrier protein.(Mol. Gen. Genet.) [1993] |
|
49
|
Q53925_STRCO (Q53925) |
|
|
3e-09 |
65.5 |
38% |
|
- Product
- Hydroxylacyl-CoA dehydrogenase
- Gene
- ORFA
SCO5071
- Organism
- Streptomyces coelicolor
|
1uniprot[Pubmed] 12000953 [Medline] 21996410 Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).(Nature) [2002] | 2uniprot[Pubmed] 7929165 [Medline] 95014254 DNA sequence and functions of the actVI region of the actinorhodin biosynthetic gene cluster of Streptomyces coelicolor A3(2).(J. Biol. Chem.) [1994] | [pubmed all]
|
50
|
Q54997_9ACTO (Q54997) |
|
|
4e-09 |
64.7 |
39% |
|
- Product
- ActVI-ORFA homolog
- Gene
- frnO
- Organism
- Streptomyces roseofulvus
|
1uniprot[Pubmed] 8181754 [Medline] 94237486 Cloning, sequencing and deduced functions of a cluster of Streptomyces genes probably encoding biosynthesis of the polyketide antibiotic frenolicin.(Gene) [1994] |
|
51
|
B6SEE8_9ACTO (B6SEE8) |
|
|
2e-08 |
63.2 |
36% |
|
- Product
- Aln2
- Gene
- aln2
- Organism
- Streptomyces sp. CM020
|
1uniprot[Pubmed] 18940666 Characterization of the alnumycin gene cluster reveals unusual gene products for pyran ring formation and dioxan biosynthesis.(Chem. Biol.) [2008] |
|
52
|
C7PWR4_CATAD (C7PWR4) |
|
|
2e-08 |
62.4 |
36% |
|
- Product
- Aromatic-ring-hydroxylating dioxygenase beta subunit
- Gene
- Caci_6494
- Organism
- Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
|
1uniprot Complete genome sequence of Catenulispora acidiphila type strain (ID 139908).(Stand. Genomic Sci.) [2009] |
|
53
|
D1A615_THECD (D1A615) |
|
|
4e-07 |
58.5 |
36% |
|
- Product
- Putative uncharacterized protein
- Gene
- Tcur_2764
- Organism
- Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
|
1uniprot Complete genome sequence of Thermomonospora curvata type strain (B9).(Stand. Genomic Sci.) [2011] |
|
54
|
Q0KJU4_9SPHN (Q0KJU4) |
|
|
8e-05 |
50.4 |
26% |
|
- Product
- Anthranilate dioxygenase small subunit
- Gene
- andAd
- Organism
- Sphingomonas sp. KA1
|
1uniprot[Pubmed] 17172338 The Sphingomonas plasmid pCAR3 is involved in complete mineralization of carbazole.(J. Bacteriol.) [2007] | 2uniprot[Pubmed] 12052549 [Medline] 22047665 Sphingomonas sp. strain KA1, carrying a carbazole dioxygenase gene homologue, degrades chlorinated dibenzo-p-dioxins in soil.(FEMS Microbiol. Lett.) [2002] | 3uniprot[Pubmed] 15277751 Divergent structures of carbazole degradative car operons isolated from gram-negative bacteria.(Biosci. Biotechnol. Biochem.) [2004] | 4uniprot[Pubmed] 15796992 Diversity of carbazole-degrading bacteria having the car gene cluster: isolation of a novel gram-positive carbazole-degrading bacterium.(FEMS Microbiol. Lett.) [2005] | 5uniprot[Pubmed] 16672458 Plasmid pCAR3 contains multiple gene sets involved in the conversion of carbazole to anthranilate.(Appl. Environ. Microbiol.) [2006] | [pubmed all]
|
55
|
D5IGH1_9SPHN (D5IGH1) |
|
|
8e-05 |
50.4 |
26% |
|
- Product
- AntAd
- Gene
- antAd
- Organism
- Sphingomonas sp. XLDN2-5
|
1uniprot[Pubmed] 20368802 The genes coding for the conversion of carbazole to catechol are flanked by IS6100 elements in Sphingomonas sp. strain XLDN2-5.(PLoS ONE) [2010] |
|