| Alanine racemization(NFUNC_0063) | 
| 必須 | A | ALR (NRULE_0228) | Alanine racemase | Clim_2128 | 
|---|
| n-alkane hydroxylation(NFUNC_0008) | 
| 必須 | A | CYP153 (NRULE_0041) | Cytochrome P450 CYP153 |  | 
|---|
| B | ALKB (NRULE_0024) | Alkane 1-monooxygenase |  | 
| C | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit |  | 
| MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit |  | 
| FDR1 (NRULE_0032) | Oxygenase electron transfer component |  | 
| MME (NRULE_0033) | Multicomponent monooxygenase effector protein |  | 
| 任意 |  | RUBA (NRULE_0039) | Rubredoxin | Clim_0177 Clim_1240 | 
|---|
|  | RUBB (NRULE_0040) | Rubredoxin reductase |  | 
|  | MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit |  | 
|  | MMG2 (NRULE_0030) | Multicomponent monooxygenase gamma subunit |  | 
|  | MMG3 (NRULE_0031) | Multicomponent monooxygenase gamma subunit |  | 
|  | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | Clim_0383 Clim_0361 Clim_1161 Clim_1229 Clim_1747 | 
| Aniline degradation (conversion into catechol)(NFUNC_0075) | 
| 必須 | A | ATDA1 (NRULE_0240) | Gamma-glutamylanilide synthetase |  | 
|---|
| ATDA3 (NRULE_0357) | Aniline dioxygenase large subunit |  | 
| ATDA4 (NRULE_0358) | Aniline dioxygenase small subunit |  | 
| 任意 |  | ATDA2 (NRULE_0241) | Putative gamma-glutamylanilide hydrolase |  | 
|---|
|  | FDR1 (NRULE_0032) | Oxygenase electron transfer component |  | 
|  | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | Clim_0361 Clim_1747 Clim_0383 Clim_1161 Clim_1229 | 
|  | FDR2 (NRULE_0057) | Ferredoxin reductase |  | 
| Anthranilate biosynthesis(NFUNC_0038) | 
| 必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | Clim_0394 | 
|---|
| TRPE (NRULE_0143) | Anthranilate synthase component I | Clim_1674 | 
| Anthranilate degradation (via hydroxylation)(NFUNC_0018) | 
| 必須 | A | ANTA (NRULE_0044) | Anthranilate 1,2-dioxygenase large subunit |  | 
|---|
| ANTB (NRULE_0045) | Anthranilate 1,2-dioxygenase small subunit |  | 
| 任意 |  | ANTC (NRULE_0081) | Anthranilate 1,2-dioxygenase electron transfer component |  | 
|---|
|  | FDR1 (NRULE_0032) | Oxygenase electron transfer component |  | 
|  | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | Clim_0383 Clim_1229 Clim_1747 Clim_0361 Clim_1161 | 
|  | FDR2 (NRULE_0057) | Ferredoxin reductase |  | 
| Aromatic hydrocarbon degradation (via hydroxylation by dioxygenase)(NFUNC_0016) | 
| 必須 | A | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit |  | 
|---|
| RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit |  | 
| CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase |  | 
| 任意 |  | FDR1 (NRULE_0032) | Oxygenase electron transfer component |  | 
|---|
|  | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | Clim_1229 Clim_0361 Clim_0383 Clim_1161 Clim_1747 | 
|  | FDR2 (NRULE_0057) | Ferredoxin reductase |  | 
| Arsenical resistance(NFUNC_0004) | 
| 必須 | A | ARSB1 (NRULE_0015) | Arsenical pump membrane protein |  | 
|---|
| ARSC1 (NRULE_0017) | Arsenate reductase |  | 
| B | ARSB1 (NRULE_0015) | Arsenical pump membrane protein |  | 
| ARSC2 (NRULE_0018) | Arsenate reductase |  | 
| C | ARSB1 (NRULE_0015) | Arsenical pump membrane protein |  | 
| ARSC3 (NRULE_0019) | Arsenate reductase |  | 
| D | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | Clim_2021 | 
| ARSC1 (NRULE_0017) | Arsenate reductase |  | 
| E | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | Clim_2021 | 
| ARSC2 (NRULE_0018) | Arsenate reductase |  | 
| F | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | Clim_2021 | 
| ARSC3 (NRULE_0019) | Arsenate reductase |  | 
| 任意 |  | ARSA (NRULE_0014) | Arsenical pump-driving ATPase | Clim_1216 Clim_2143 Clim_2147 Clim_2364 Clim_0551 Clim_0966 Clim_0078 | 
|---|
|  | ARSD (NRULE_0020) | Arsenical resistance operon trans-acting repressor ArsD |  | 
|  | ARSH (NRULE_0021) | ArsH protein |  | 
| Artificial lacto-N-biose biosynthesis(NFUNC_0026) | 
| 必須 | A | SP (NRULE_0109) | Sucrose phosphorylase |  | 
|---|
| GALT (NRULE_0110) | Galactose-1-phosphate uridylyltransferase |  | 
| GALE (NRULE_0111) | UDP-glucose 4-epimerase | Clim_1776 | 
| LNBP (NRULE_0112) | 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase |  | 
| Bacitracin resistance(NFUNC_0022) | 
| 必須 | A | UPPP (NRULE_0097) | Undecaprenyl-diphosphatase | Clim_1735 | 
|---|
| Benzoate degradation (via hydroxylation by dioxygenase)(NFUNC_0017) | 
| 必須 | A | BENA (NRULE_0046) | Benzoate 1,2-dioxygenase alpha subunit |  | 
|---|
| BENB (NRULE_0047) | Benzoate 1,2-dioxygenase beta subunit |  | 
| BEND (NRULE_0082) | 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase |  | 
| 任意 |  | BENC (NRULE_0055) | Benzoate 1,2-dioxygenase electron transfer component |  | 
|---|
|  | FDR1 (NRULE_0032) | Oxygenase electron transfer component |  | 
|  | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | Clim_0383 Clim_0361 Clim_1229 Clim_1161 Clim_1747 | 
|  | FDR2 (NRULE_0057) | Ferredoxin reductase |  | 
| Biotin biosynthesis(NFUNC_0051) | 
| 必須 | A | BIOF (NRULE_0182) | 8-amino-7-oxononanoate synthase |  | 
|---|
| BIOA (NRULE_0183) | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | Clim_2425 | 
| BIOD (NRULE_0184) | ATP-dependent dethiobiotin synthetase BioD | Clim_2426 | 
| BIOB (NRULE_0185) | Biotin synthase | Clim_2430 | 
| Dibenzothiophene degradation (via desulfurization)(NFUNC_0029) | 
| 必須 | A | DSZA (NRULE_0103) | Dibenzothiophene-5,5-dioxide monooxygenase |  | 
|---|
| DSZB (NRULE_0104) | 2'-hydroxybiphenyl-2-sulfinate desulfinase |  | 
| DSZC (NRULE_0105) | Dibenzothiophene monooxygenase |  | 
| 任意 |  | FADR1 (NRULE_0101) | NADH-dependent flavin reductase | Clim_0642 | 
|---|
| Folate biosynthesis(NFUNC_0044) | 
| 必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | Clim_0394 | 
|---|
| DHPS (NRULE_0144) | Dihydropteroate synthase | Clim_1985 | 
| FOLM (NRULE_0146) | Dihydrofolate reductase FolM |  | 
| FOLB (NRULE_0158) | Dihydroneopterin aldolase | Clim_2140 | 
| FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | Clim_2141 | 
| FOLC (NRULE_0160) | Bifunctional protein FolC | Clim_0322 | 
| PABB (NRULE_0161) | Para-aminobenzoate synthase component I | Clim_1992 | 
| PABC (NRULE_0162) | Aminodeoxychorismate lyase |  | 
| B | GLAT (NRULE_0142) | Glutamine amidotransferase | Clim_0394 | 
| DHPS (NRULE_0144) | Dihydropteroate synthase | Clim_1985 | 
| FOLA (NRULE_0147) | Dihydrofolate reductase |  | 
| FOLB (NRULE_0158) | Dihydroneopterin aldolase | Clim_2140 | 
| FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | Clim_2141 | 
| FOLC (NRULE_0160) | Bifunctional protein FolC | Clim_0322 | 
| PABB (NRULE_0161) | Para-aminobenzoate synthase component I | Clim_1992 | 
| PABC (NRULE_0162) | Aminodeoxychorismate lyase |  | 
| C | GLAT (NRULE_0142) | Glutamine amidotransferase | Clim_0394 | 
| DHPS (NRULE_0144) | Dihydropteroate synthase | Clim_1985 | 
| DFR2 (NRULE_0148) | Dihydrofolate reductase type 2 |  | 
| FOLB (NRULE_0158) | Dihydroneopterin aldolase | Clim_2140 | 
| FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | Clim_2141 | 
| FOLC (NRULE_0160) | Bifunctional protein FolC | Clim_0322 | 
| PABB (NRULE_0161) | Para-aminobenzoate synthase component I | Clim_1992 | 
| PABC (NRULE_0162) | Aminodeoxychorismate lyase |  | 
| Human milk oligosaccharides metabolism(NFUNC_0083) | 
| 必須 | A | LNBP (NRULE_0112) | 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase |  | 
|---|
| 任意 |  | NAHK (NRULE_0256) | N-acetylhexosamine 1-kinase |  | 
|---|
|  | GALT (NRULE_0110) | Galactose-1-phosphate uridylyltransferase |  | 
|  | GALE (NRULE_0111) | UDP-glucose 4-epimerase | Clim_1776 | 
| 4-hydroxyphenylacetate degradation(NFUNC_0068) | 
| 必須 | A | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component |  | 
|---|
| HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component |  | 
| HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase |  | 
| HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase |  | 
| HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase |  | 
| HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase |  | 
| HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase |  | 
| HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase |  | 
| B | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component |  | 
| HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component |  | 
| HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase |  | 
| HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase |  | 
| HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase |  | 
| HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase |  | 
| HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase |  | 
| HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase |  | 
| C | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component |  | 
| FADR1 (NRULE_0101) | NADH-dependent flavin reductase | Clim_0642 | 
| HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase |  | 
| HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase |  | 
| HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase |  | 
| HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase |  | 
| HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase |  | 
| HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase |  | 
| D | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component |  | 
| FADR1 (NRULE_0101) | NADH-dependent flavin reductase | Clim_0642 | 
| HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase |  | 
| HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase |  | 
| HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase |  | 
| HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase |  | 
| HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase |  | 
| HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase |  | 
| E | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component |  | 
| FADR1 (NRULE_0101) | NADH-dependent flavin reductase | Clim_0642 | 
| HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase |  | 
| HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase |  | 
| HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase |  | 
| HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase |  | 
| HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase |  | 
| HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase |  | 
| F | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component |  | 
| FADR1 (NRULE_0101) | NADH-dependent flavin reductase | Clim_0642 | 
| HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase |  | 
| HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase |  | 
| HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase |  | 
| HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase |  | 
| HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase |  | 
| HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase |  | 
| G | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component |  | 
| HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component |  | 
| HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase |  | 
| HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase |  | 
| HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase |  | 
| HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase |  | 
| HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase |  | 
| HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase |  | 
| H | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component |  | 
| HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component |  | 
| HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase |  | 
| HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase |  | 
| HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase |  | 
| HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase |  | 
| HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase |  | 
| HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase |  | 
| Metal-binding protein(NFUNC_0105) | 
| 必須 | A | MOP (NRULE_0322) | Putative molybdenum-binding protein | Clim_0673 Clim_0373 | 
|---|
| B | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | Clim_0673 | 
| C | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | Clim_0675 Clim_0374 | 
| D | MNTR (NRULE_0327) | DtxR family transcriptional regulator MntR |  | 
| E | CUER (NRULE_0328) | Copper-responsive transcriptional regulator CueR |  | 
| F | SOXR (NRULE_0329) | Redox-sensitive transcriptional activator SoxR |  | 
| G | ZNTR (NRULE_0330) | Zinc-responsive transcriptional regulator ZntR |  | 
| H | NIKR (NRULE_0331) | Nickel-responsive transcriptional regulator NikR | Clim_2003 | 
| I | ISCR (NRULE_0332) | Rrf2 family transcriptional regulator IscR |  | 
| J | SMTA (NRULE_0009) | Metallothionein |  | 
| Molybdate transport (ABC transporter)(NFUNC_0097) | 
| 必須 | A | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | Clim_0675 Clim_0374 | 
|---|
| 任意 |  | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | Clim_0673 | 
|---|
|  | MODB (NRULE_0325) | Molybdate ABC transporter permease protein | Clim_0372 | 
|  | MODC (NRULE_0326) | Molybdate ABC transporter ATP-binding protein | Clim_0371 | 
| Naphthalene degradation (via hydroxylation by dioxygenase)(NFUNC_0067) | 
| 必須 | A | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit |  | 
|---|
| RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit |  | 
| CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase |  | 
| EDIO (NRULE_0058) | extradiol dioxygenase |  | 
| NAHD (NRULE_0171) | 2-hydroxychromene-2-carboxylate isomerase |  | 
| NAHE (NRULE_0172) | Trans-O-hydroxybenzylidenepyruvate hydratase-aldolase |  | 
| NAHF (NRULE_0173) | Salicylaldehyde dehydrogenase |  | 
| NAHG (NRULE_0190) | Salicylate hydroxylase |  | 
| B | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit |  | 
| RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit |  | 
| CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase |  | 
| EDIO (NRULE_0058) | extradiol dioxygenase |  | 
| NAHD (NRULE_0171) | 2-hydroxychromene-2-carboxylate isomerase |  | 
| NAHE (NRULE_0172) | Trans-O-hydroxybenzylidenepyruvate hydratase-aldolase |  | 
| NAHF (NRULE_0173) | Salicylaldehyde dehydrogenase |  | 
| NAGG (NRULE_0191) | Salicylate 5-hydroxylase alpha subunit |  | 
| NAGH (NRULE_0192) | Salicylate 5-hydroxylase beta subunit |  | 
| 任意 |  | FDR1 (NRULE_0032) | Oxygenase electron transfer component |  | 
|---|
|  | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | Clim_1229 Clim_0361 Clim_1747 Clim_0383 Clim_1161 | 
|  | FDR2 (NRULE_0057) | Ferredoxin reductase |  | 
| Nitrogenase(NFUNC_0094) | 
| 必須 | A | NIFD (NRULE_0347) | Nitrogenase molybdenum-iron protein alpha chain | Clim_0682 | 
|---|
| NIFK (NRULE_0348) | Nitrogenase molybdenum-iron protein beta chain | Clim_0681 | 
| VNFH (NRULE_0353) | Nitrogenase reductase | Clim_0685 | 
| B | ANFD (NRULE_0344) | Nitrogenase iron-iron protein alpha chain |  | 
| ANFK (NRULE_0345) | Nitrogenase iron-iron protein beta chain |  | 
| ANFG (NRULE_0346) | Nitrogenase iron-iron protein delta chain |  | 
| VNFH (NRULE_0353) | Nitrogenase reductase | Clim_0685 | 
| C | VNFD (NRULE_0349) | Nitrogenase vanadium-iron protein alpha chain |  | 
| VNFK (NRULE_0351) | Nitrogenase vanadium-iron protein beta chain |  | 
| VNFG (NRULE_0352) | Nitrogenase vanadium-iron protein delta chain |  | 
| VNFH (NRULE_0353) | Nitrogenase reductase | Clim_0685 | 
| D | VNFK (NRULE_0350) | Nitrogenase vanadium-iron protein alpha/delta chain |  | 
| VNFK (NRULE_0351) | Nitrogenase vanadium-iron protein beta chain |  | 
| VNFH (NRULE_0353) | Nitrogenase reductase | Clim_0685 | 
| (R)-pantothenate biosynthesis(NFUNC_0030) | 
| 必須 | A | PAND (NRULE_0115) | Aspartate 1-decarboxylase | Clim_0310 | 
|---|
| PANB (NRULE_0116) | 3-methyl-2-oxobutanoate hydroxymethyltransferase | Clim_1526 | 
| PANE (NRULE_0117) | 2-dehydropantoate 2-reductase |  | 
| PANC (NRULE_0118) | Pantothenate synthetase | Clim_0600 | 
| Phenol degradation(NFUNC_0028) | 
| 必須 | A | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit |  | 
|---|
| MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit |  | 
| MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit |  | 
| B | PHEA1 (NRULE_0083) | Aromatic ring hydroxylase |  | 
| C | PHEA2 (NRULE_0084) | Aromatic ring hydroxylase |  | 
| 任意 |  | FDR2 (NRULE_0057) | Ferredoxin reductase |  | 
|---|
|  | FDR1 (NRULE_0032) | Oxygenase electron transfer component |  | 
|  | MME (NRULE_0033) | Multicomponent monooxygenase effector protein |  | 
|  | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | Clim_1747 Clim_0383 Clim_1161 Clim_0361 Clim_1229 | 
|  | FADR1 (NRULE_0101) | NADH-dependent flavin reductase | Clim_0642 | 
| Phytic acid hydrolysis(NFUNC_0085) | 
| 必須 | A | PHYT (NRULE_0258) | 3-phytase | Clim_1122 | 
|---|
| B | APPA (NRULE_0259) | Periplasmic AppA protein |  | 
| Riboflavin biosynthesis(NFUNC_0058) | 
| 必須 | A | RIBB (NRULE_0200) | 3,4-dihydroxy-2-butanone 4-phosphate synthase | Clim_0178 Clim_1966 | 
|---|
| RIBA (NRULE_0201) | GTP cyclohydrolase-2 | Clim_1966 | 
| RIBD (NRULE_0202) | Riboflavin biosynthesis protein RibD | Clim_0829 | 
| RIBH (NRULE_0203) | 6,7-dimethyl-8-ribityllumazine synthase | Clim_2336 | 
| RIBE (NRULE_0204) | Riboflavin synthase | Clim_0835 | 
| 任意 |  | RIBF (NRULE_0205) | Riboflavin biosynthesis protein RibF | Clim_0303 | 
|---|
| Toluene degradation (conversion into protocatechuate via p-cresol)(NFUNC_0007) | 
| 必須 | A | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit |  | 
|---|
| MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit |  | 
| FDR1 (NRULE_0032) | Oxygenase electron transfer component |  | 
| MME (NRULE_0033) | Multicomponent monooxygenase effector protein |  | 
| PCHF (NRULE_0035) | 4-cresol dehydrogenase flavoprotein subunit |  | 
| PCHC (NRULE_0036) | 4-cresol dehydrogenase cytochrome c subunit |  | 
| PCHA (NRULE_0037) | p-hydroxybenzaldehyde dehydrogenase |  | 
| POBA (NRULE_0038) | p-hydroxybenzoate hydroxylase |  | 
| 任意 |  | MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit |  | 
|---|
|  | MMG2 (NRULE_0030) | Multicomponent monooxygenase gamma subunit |  | 
|  | MMG3 (NRULE_0031) | Multicomponent monooxygenase gamma subunit |  | 
|  | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | Clim_1747 Clim_1229 Clim_0383 Clim_0361 Clim_1161 | 
| Trehalose biosynthesis (from maltose)(NFUNC_0034) | 
| 必須 | A | MAPA (NRULE_0126) | Maltose phosphorylase |  | 
|---|
| TREP (NRULE_0127) | Alpha,alpha-trehalose phosphorylase |  | 
| B | TRES (NRULE_0128) | Trehalose synthase | Clim_2378 | 
| Vitamin B6 biosynthesis (PdxA/PdxJ pathway)(NFUNC_0060) | 
| 必須 | A | EPD (NRULE_0208) | D-erythrose-4-phosphate dehydrogenase |  | 
|---|
| PDXB (NRULE_0209) | Erythronate-4-phosphate dehydrogenase |  | 
| SERC (NRULE_0210) | Phosphoserine aminotransferase |  | 
| PDXA (NRULE_0211) | 4-hydroxythreonine-4-phosphate dehydrogenase | Clim_0541 | 
| PDXJ (NRULE_0212) | Pyridoxine 5'-phosphate synthase | Clim_1733 |