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遺伝子 : Ring-hydroxylating dioxygenase alpha subunit (RHDA)

遺伝子情報

ID NRULE_0048
遺伝子ID RHDA
作成日 2012/08/21
タンパク質名
Protein name
Full
Ring-hydroxylating dioxygenase alpha subunit
EC
EC 1.14.-.-
Synonym
Full
Aromatic ring-hydroxylating dioxygenase large subunit
遺伝子名 該当データなし
遺伝子条件 PRINTS; PR00090; hit=1ANDPFAM; PF00848; hit=1
OR
PFAM; PF00355; hit=1ANDPFAM; PF00848; hit=1
参照
Gene Ontology
GO
GO:0051537, F:2 iron, 2 sulfur cluster binding, IEA:UniProtKB-KW
GO:0016702, F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, IEA:UniProtKB-KW
GO:0005506, F:iron ion binding, IEA:InterPro
Family and domain databases
InterPro
IPR017941, Rieske_2Fe-2S
IPR015881, Ring-hydroxy_dOase_2Fe2S_BS
IPR015879, Ring_hydroxy_dOase_asu_C_dom
IPR001663, Rng_hydr_dOase-A
Pfam
PF00355, Rieske, 1
PF00848, Ring_hydroxyl_A, 1
PRINTS
PR00090, RNGDIOXGNASE
PROSITE
PS51296, RIESKE, 1
PS00570, RING_HYDROXYL_ALPHA, 1
配列の特徴
Q53122 Rhodococcus jostii (strain RHA1).
METAL98Iron-sulfur (2Fe-2S).
METAL100Iron-sulfur (2Fe-2S); via pros nitrogen.
METAL118Iron-sulfur (2Fe-2S).
METAL121Iron-sulfur (2Fe-2S); via pros nitrogen.
METAL123Iron-sulfur (2Fe-2S).
METAL217Iron.
METAL224Iron; via tele nitrogen.
METAL230Iron; via tele nitrogen.
METAL378Iron.
P0A110 Pseudomonas putida (Arthrobacter siderocapsulatus).
METAL81Iron-sulfur (2Fe-2S).
METAL83Iron-sulfur (2Fe-2S); via pros nitrogen.
METAL101Iron-sulfur (2Fe-2S).
METAL104Iron-sulfur (2Fe-2S); via pros nitrogen.
METAL208Iron.
METAL213Iron.
METAL362Iron.
注釈
Function
Catalyzes the initial reactions (ring-dihydroxylation) of the aromatic compound degradation
Catalytic activity
Aromatic compound + NADH + O(2) = cis-dihydrodiol compound + NAD(+)
Cofactor
Binds 1 2Fe-2S cluster per subunit (By similarity)
Binds 1 iron ion per subunit (By similarity)
Pathway
Aromatic compound metabolism;
Subunit structure
Aromatic ring-hydroxylating dioxygenase system consists of three or four proteins: the two subunits of the hydroxylase component (alpha (large) and beta (small)), the electron transfer component (ferredoxin and ferredoxin reductase)
Sequence similarities
Belongs to the bacterial ring-hydroxylating dioxygenase alpha subunit family
Contains 1 Rieske domain
参考文献
Q07944 Pseudomonas putida (Arthrobacter siderocapsulatus).
8344526
The Pseudomonas putida ML2 plasmid-encoded genes for benzene dioxygenase are unusual in codon usage and low in G+C content. (Gene. 1993)
A5W4F2 Pseudomonas putida (strain F1 / ATCC 700007).
2670929
Toluene degradation by Pseudomonas putida F1. Nucleotide sequence of the todC1C2BADE genes and their expression in Escherichia coli. (J Biol Chem. 1989)
Q53122 Rhodococcus jostii (strain RHA1).
7793929
Characterization of biphenyl catabolic genes of gram-positive polychlorinated biphenyl degrader Rhodococcus sp. strain RHA1. (Appl Environ Microbiol. 1995)
P0A110 Pseudomonas putida (Arthrobacter siderocapsulatus).
3243438
Cloning, nucleotide sequence and characterization of genes encoding naphthalene dioxygenase of Pseudomonas putida strain NCIB9816. (Gene. 1988)



関与する機能

機能名
Aromatic hydrocarbon degradation (via hydroxylation by dioxygenase)
Naphthalene degradation (via hydroxylation by dioxygenase)

該当CDS

データダウンロード
学名 NBRC番号 CDS タンパク質名
Acetobacter aceti14818AaceN1_010100013207iron-sulfur cluster-binding protein 1
Acetobacter pasteurianus105190APA32_22050Ring hydroxylating dioxygenase
Acetobacter pasteurianus101655APT_2201ring hydroxylating dioxygenase
Acetobacter tropicalis101654ATPR_0338ring hydroxylating dioxygenase
Acidiphilium multivorum100883ACMV_08840putative iron-sulfur protein
ACMV_23130putative iron-sulfur protein
Acinetobacter radioresistens102413ACRAD_06_00560putative 3-phenylpropionate dioxygenase subunit alpha
ACRAD_11_01100anthranilate 1,2-dioxygenase large subunit
ACRAD_20_00020benzoate 1,2-dioxygenase large subunit
ACRAD_20_01460anthranilate 1,2-dioxygenase large subunit
Acinetobacter sp.100985ACT4_038_00460benzoate 1,2-dioxygenase large subunit
Alteromonas macleodii102226MASE_12030dioxygenase subunit alpha oxidoreductase
Amycolatopsis azurea14573C791_3220Phenylpropionate dioxygenase
C791_58763-phenylpropionate dioxygenase alpha subunit
Amycolatopsis mediterranei13415RAM_38825rieske 2Fe-2S family protein
Arthrobacter globiformis12137ARGLB_011_00120putative iron-sulfur protein
ARGLB_044_00020putative iron-sulfur protein
Azorhizobium caulinodans14845AZC_1173iron-sulfur cluster-binding protein 1
Bradyrhizobium diazoefficiens14792blr3400putative oxidoreductase
blr4922probable Phenoxybenzoate dioxygenase alpha subunit (EC 1.14.12.-)
Brevibacterium linens12170BlinB_010200003819Rieske (2Fe-2S) domain-containing protein
BlinB_010200015027Rieske (2Fe-2S) domain protein
Caldilinea aerophila104270CLDAP_18710putative oxidoreductase
Caldisericum exile104410CSE_12880putative oxidoreductase
Candidatus Solibacter usitatusAcid_2549Rieske (2Fe-2S) domain protein
Catenulispora acidiphila102108Caci_7447Rieske (2Fe-2S) domain protein
Caulobacter segnis15250Cseg_0832Rieske (2Fe-2S) iron-sulfur domain protein
Cseg_1798Rieske (2Fe-2S) iron-sulfur domain protein
Chromobacterium violaceum12614CV_1532probable dioxygenase, alpha subunit
Conexibacter woesei100937Cwoe_0435Aromatic-ring-hydroxylating dioxygenase, alpha subunit-like protein
Cwoe_4003Rieske (2Fe-2S) iron-sulphur domain protein
Congregibacter litoralis104960KT71_02567Phenylpropionate dioxygenase
Corynebacterium ammoniagenes12612HMPREF0281_00561rieske [2Fe-2S] domain protein
Corynebacterium callunae15359H924_10120benzoate 1,2-dioxygenase subunit alpha
Corynebacterium efficiens100395CE2305putative benzoate 1,2-dioxygenase reductase
Corynebacterium glutamicum12168Cgl2404Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases
Corynebacterium glutamicum12153KIQ_00485hypothetical protein
Corynebacterium terpenotabidum14764A606_08180hypothetical protein
Cupriavidus metallidurans102507Rmet_26182Fe-2S (Rieske)cluster-containing dioxygenase large terminal subunit
Rmet_4882benzoate 1,2-dioxygenase, alpha subunit
Enterobacter aerogenes13534EAE_02325ring hydroxylating dioxygenase subunit alpha
EAE_15885Rieske 2Fe-2S domain protein
EAE_19895Rieske (2Fe-2S) iron-sulfur domain protein
Escherichia coli3972EcolC_1139Aromatic-ring-hydroxylating dioxygenase, alpha subunit-like protein
EcolC_1831Rieske (2Fe-2S) domain protein
Escherichia coli13500WFL_09685putative dioxygenase subunit alpha yeaW
WFL_135353-phenylpropionate/cinnamic acid dioxygenase subunit alpha
Escherichia coli12713Y75_1799predicted 2Fe-2S cluster-containing protein
Y75_25313-phenylpropionate dioxygenase, large (alpha) subunit
Escherichia fergusonii102419EFER_0798Ring hydroxylating dioxygenase, alpha subunit:Rieske [2Fe-2S] region
EFER_1482Benzoate 1,2-dioxygenase alpha subunit
Fimbriimonas ginsengisoliOP10G_2737Rieske (2Fe-2S) iron-sulfur domain-containing protein
Gemmata obscuriglobusGEMOB_RS26880dioxygenase
GEMOB_RS27295hypothetical protein
Geodermatophilus obscurus13315Gobs_1297benzoate 1,2-dioxygenase, large subunit
Gobs_2853Rieske (2Fe-2S) iron-sulphur domain protein
Gobs_2893Rieske (2Fe-2S) iron-sulphur domain protein
Gloeobacter violaceusgll0957probable dioxygenase
gll3435hypothetical protein
glr2700hypothetical protein
Gordonia aichiensis108223GOACH_04_00590putative iron-sulfur protein
GOACH_07_00580putative aromatic hydrocarbon dioxygenase large subunit
GOACH_07_01240benzoate 1,2-dioxygenase large subunit
GOACH_11_00500putative iron-sulfur protein
GOACH_12_00030p-cumate dioxygenase large subunit
GOACH_29_00260putative aromatic hydrocarbon dioxygenase large subunit
Gordonia alkanivorans16433GOALK_035_00050putative aromatic-ring-hydroxylating dioxygenase alpha subunit
GOALK_047_00120benzoate 1,2-dioxygenase large subunit
Gordonia amarae15530GOAMR_19_01110putative iron-sulfur protein
GOAMR_26_00700putative iron-sulfur protein
GOAMR_61_01300putative iron-sulfur protein
GOAMR_63_01620putative iron-sulfur protein
Gordonia amicalis100051GOAMI_40_00470benzoate 1,2-dioxygenase large subunit
Gordonia bronchialis16047Gbro_4158benzoate 1,2-dioxygenase, large subunit
Gordonia namibiensis108229GONAM_03_00230putative naphthalene dioxygenase large subunit
GONAM_20_00460putative naphthalene dioxygenase large subunit
GONAM_25_00310benzoate 1,2-dioxygenase large subunit
Gordonia otitidis100426GOOTI_035_00270putative iron-sulfur protein
GOOTI_125_00110putative iron-sulfur protein
Gordonia polyisoprenivorans16320GOPIP_011_00770benzoate 1,2-dioxygenase large subunit
GOPIP_031_00830putative iron-sulfur protein
GOPIP_094_00300putative iron-sulfur protein
GOPIP_094_00420putative iron-sulfur protein
GOPIP_094_00720putative iron-sulfur protein
GOPIP_094_00950p-cumate dioxygenase large subunit
Gordonia rhizosphera16068GORHZ_062_00790benzoate 1,2-dioxygenase large subunit
GORHZ_069_00640putative Rieske iron-sulfur protein
GORHZ_115_00200putative iron-sulfur protein
GORHZ_115_00260putative iron-sulfur protein
GORHZ_119_00390putative Rieske iron-sulfur protein
GORHZ_125_00730putative iron-sulfur protein
GORHZ_200_00180putative iron-sulfur protein
Gordonia rubripertincta101908GORBP_002_00150putative aromatic hydrocarbon dioxygenase large subunit
GORBP_060_00770benzoate 1,2-dioxygenase large subunit
GORBP_077_00670putative aromatic hydrocarbon dioxygenase large subunit
GORBP_095_00110benzoate 1,2-dioxygenase large subunit
Gordonia sihwensis108236GSI01S_20_00090putative benzene dioxygenase large subunit
GSI01S_20_00210putative benzene dioxygenase large subunit
GSI01S_28_00260putative benzoate 1,2-dioxygenase large subunit
Gordonia soli108243GS4_16_00410putative iron-sulfur protein
Gordonia sputi100414GOSPT_044_00070putative aromatic-ring-hydroxylating dioxygenase alpha subunit
GOSPT_109_00160putative iron-sulfur protein
GOSPT_141_00330benzoate 1,2-dioxygenase large subunit
Gordonia terrae100016GOTRE_011_00120putative aromatic hydrocarbon dioxygenase large subunit
GOTRE_015_00050putative oxidoreductase
GOTRE_023_00410putative iron-sulfur protein
GOTRE_023_00630putative iron-sulfur protein
GOTRE_052_00340putative iron-sulfur protein
GOTRE_125_00120benzoate 1,2-dioxygenase large subunit
Haloarcula vallismortis14741C437_07632putative dioxygenase alpha subunit YeaW
Halomonas elongata15536HELO_3452Rieske (2Fe-2S) domain protein
Hylemonella gracilis14920HGR_01262Rieske (2Fe-2S) domain-containing protein
HGR_16098rieske (2fe-2S) domain-containing protein
Kineosphaera limosa100340KILIM_015_00800putative iron-sulfur protein
Klebsiella pneumoniae14438KPR_2937
KPR_3509
Klebsiella pneumoniae subsp. rhinoscleromatis105682HMPREF0484_3754rieske [2Fe-2S] domain protein
HMPREF0484_4612rieske [2Fe-2S] domain protein
Ktedonobacter racemiferKrac_3838Aromatic-ring-hydroxylating dioxygenase, alpha subunit
Kyrpidia tusciae15312Btus_2317Rieske (2Fe-2S) iron-sulfur domain protein
Btus_2903Aromatic-ring-hydroxylating dioxygenase, alpha subunit-like protein
Labrenzia aggregata16684SIAM614_12148ring hydroxylating dioxygenase, alpha subunit
SIAM614_30621Rieske (2Fe-2S) protein
SIAM614_30821ring hydroxylating dioxygenase, Rieske (2Fe-2S) protein
Leptospira interrogansLA_1114putative ring hydroxylating dioxygenase alpha-subunit
Marinomonas mediterranea103028Marme_1561benzoate 1,2-dioxygenase, large subunit
Marme_1744Rieske (2Fe-2S) iron-sulfur domain
Marme_2404Biphenyl 2,3-dioxygenase
Marme_3617Benzoate 1,2-dioxygenase
Meiothermus ruber106122Mrub_0721Choline monooxygenase
Mrub_2685Aromatic-ring-hydroxylating dioxygenase, alpha subunit
Meiothermus silvanus106475Mesil_2803Rieske (2Fe-2S) iron-sulfur domain protein
Methylobacterium radiotolerans15690Mrad2831_2476Rieske (2Fe-2S) domain protein
Microlunatus phosphovorus101784MLP_09950putative iron-sulfur protein
MLP_20330putative iron-sulfur protein
Micromonospora aurantiaca16155Micau_4014Rieske (2Fe-2S) iron-sulphur domain
Nitriliruptor alkaliphilusNitalDRAFT_07493-phenylpropionate/trans-cinnamate dioxygenase alpha subunit
NitalDRAFT_1726Phenylpropionate dioxygenase, large terminal subunit
NitalDRAFT_4752Phenylpropionate dioxygenase, large terminal subunit
NitalDRAFT_4814Phenylpropionate dioxygenase, large terminal subunit
Nitrosomonas europaea14298NE1503Rieske iron-sulfur protein 2Fe-2S subunit
Ochrobactrum anthropi15819Oant_1712Rieske (2Fe-2S) domain protein
Ochrobactrum intermedium15820OINT_1001594Biphenyl dioxygenase subunit alpha
Phaeobacter gallaeciensis16654PGA1_262p01370putative dioxygenase
PGA1_c05010putative dioxygenase
Phycisphaera mikurensis102666PSMK_13270putative oxidoreductase
Pseudomonas putida100650PP_0315Rieske 2Fe-2S family protein
PP_3161benzoate dioxygenase, alpha subunit
PP_5373Rieske 2Fe-2S family protein
Pseudomonas stutzeri14165PSTAB_1578benzoate dioxygenase, alpha subunit
Rhizobium etli15573RHE_CH00901probable dioxygenase protein
RHE_PF00388putative dyoxygenase (alpha subunit) oxidoreductase protein
Rhizobium sp.101917NGR_b23410putative aromatic-ring hydroxylating dioxygenase, alpha-subunit
NGR_c04860putative dioxygenase, alpha-subunit
NGR_c26320putative ring hydroxylating dioxygenase subunit
Rhizobium tropici15247RTCIAT899_CH04350ring hydroxylating dioxygenase, alpha-subunit
Rhodobacter capsulatus16581RCAP_rcc03351rieske (2Fe-2S) domain protein
Rhodobacter sphaeroides12203RSP_3978ring hydroxylating dioxygenase, alpha subunit
Rhodococcus opacus108011ROP_14870putative iron-sulfur protein
ROP_17790putative iron-sulfur protein
ROP_18030putative iron-sulfur protein
ROP_20980benzoate 1,2-dioxygenase large subunit
ROP_24850putative iron-sulfur protein
ROP_25670putative aromatic hydrocarbon dioxygenase large subunit
ROP_28570putative oxidoreductase
ROP_31670putative iron-sulfur protein
ROP_46340p-cumate dioxygenase large subunit
ROP_71710putative aromatic hydrocarbon dioxygenase large subunit
ROP_pROB02-01580benzene dioxygenase large subunit
ROP_pROB02-02050naphthalene dioxygenase large subunit
Roseobacter denitrificans15277RD1_1031Rieske 2Fe-2S domain protein
RD1_2816Rieske 2Fe-2S domain protein, putative
RD1_3683vanillate O-demethylase oxygenase, putative
Roseobacter litoralis15278RLO149_c002360hypothetical protein
RLO149_c007670vanillate O-demethylase oxygenase-like protein
RLO149_c016240putative aromatic-ring-hydroxylating dioxygenase
Rubrobacter xylanophilus100952Rxyl_1560Rieske (2Fe-2S) region
Saccharomonospora azurea14651SacazDRAFT_04276ring-hydroxylating dioxygenase, large terminal subunit
Saccharomonospora cyanea14841SaccyDRAFT_1685benzoate 1,2-dioxygenase, large subunit
Saccharomonospora viridis12207Svir_18770ring-hydroxylating dioxygenase, large terminal subunit
Saccharopolyspora erythraea13426SACE_3150ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenase
SACE_4379benzoate 1,2-dioxygenase alpha subunit
SACE_4514ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenase
Saccharopolyspora spinosa15153SspiN1_0101000034332Fe-2S ferredoxin
SspiN1_0101000072302Fe-2S ferredoxin
SspiN1_010100008220(Fe-S)-binding protein
Shimwellia blattae105725EB105725_04_000703-phenylpropionate/cinnamic acid dioxygenase alpha subunit
EB105725_04_02040putative dioxygenase alpha subunit YeaW
EB105725_23_004503-phenylpropionate/cinnamic acid dioxygenase alpha subunit
EB105725_26_004403-phenylpropionate/cinnamic acid dioxygenase alpha subunit
Solitalea canadensis15130Solca_1122ring-hydroxylating dioxygenase, large terminal subunit
Sphingobium japonicum101211SJA_C1-05560putative dioxygenase
SJA_C1-25220large subunit of anthranilate dioxygenase
SJA_C1-27080putative dioxygenase large terminal subunit
SJA_C2-03710putative dioxygenase
SJA_C2-04080putative dioxygenase
Sphingobium sp.103272SLG_16640aromatic-ring-hydroxylating dioxygenase alpha subunit
Sphingomonas echinoides15742SechA1_010100000565(2Fe-2S)-binding protein
SechA1_010100004978(2Fe-2S)-binding protein
SechA1_010100004983(2Fe-2S)-binding protein
SechA1_010100005008(2Fe-2S)-binding protein
SechA1_0101000061282Fe-2S ferredoxin
SechA1_010100006910(2Fe-2S)-binding protein
Sphingomonas wittichii105917Swit_0324Rieske (2Fe-2S) domain protein
Swit_0336Rieske (2Fe-2S) domain protein
Swit_0538Rieske (2Fe-2S) domain protein
Swit_0744Rieske (2Fe-2S) domain protein
Swit_0890ring hydroxylating dioxygenase, alpha subunit
Swit_0896Rieske (2Fe-2S) domain protein
Swit_0932Rieske (2Fe-2S) domain protein
Swit_0962Rieske (2Fe-2S) domain protein
Swit_0966Rieske (2Fe-2S) domain protein
Swit_0973Rieske (2Fe-2S) domain protein
Swit_1531Rieske (2Fe-2S) domain protein
Swit_1559Vanillate monooxygenase
Swit_1758ring hydroxylating dioxygenase, alpha subunit
Swit_1874Rieske (2Fe-2S) domain protein
Swit_1988Rieske (2Fe-2S) domain protein
Swit_2253Rieske (2Fe-2S) domain protein
Swit_2260Rieske (2Fe-2S) domain protein
Swit_2261Rieske (2Fe-2S) domain protein
Swit_2271Rieske (2Fe-2S) domain protein
Swit_2634benzoate 1,2-dioxygenase, alpha subunit
Swit_3056Rieske (2Fe-2S) domain protein
Swit_4150Rieske (2Fe-2S) domain protein
Swit_4174Rieske (2Fe-2S) domain protein
Swit_4188Rieske (2Fe-2S) domain protein
Swit_4280Rieske (2Fe-2S) domain protein
Swit_4621Rieske (2Fe-2S) domain protein
Swit_4897ring hydroxylating dioxygenase, alpha subunit
Sporichthya polymorpha12702Spopo_30_02700P-cumate dioxygenase large subunit
Spopo_30_05730Rieske domain protein
Spopo_30_06220Rieske (2Fe-2S) domain protein
Spopo_31_00300Putative dioxygenase hydroxylase component
Spopo_31_00330Rieske (2Fe-2S) domain protein
Spopo_31_00730Ring hydroxylating diooxygenase
Spopo_31_01060Putative iron-sulfur protein
Spopo_31_14820Rieske (2Fe-2S) protein
Stackebrandtia nassauensis102104Snas_2770Rieske (2Fe-2S) domain protein
Snas_5229Rieske (2Fe-2S) domain protein
Starkeya novella14993Snov_3016Rieske (2Fe-2S) iron-sulfur domain protein
Streptomyces avermitilis14893SAV6949hypothetical protein
Streptomyces clavuligerus13307SCLAV_1842Putative ring-hydroxylating dioxygenase
Streptomyces ghanaensis15414SSFG_00020Rieske 2Fe-2S family protein
SSFG_07172benzoate 1,2-dioxygenase alpha subunit
Streptomyces sviceus13980SSEG_05610dioxyenase
Streptosporangium roseum3776Sros_3851Rieske (2Fe-2S) protein
Thauera linaloolentis102519C666_03535putative iron-sulfur protein
C666_10180p-cumate dioxygenase large subunit (CmtAb)
C666_11275Rieske (2Fe-2S) domain-containing protein
C666_11320Rieske (2Fe-2S) protein
C666_11415Rieske (2Fe-2S) domain-containing protein
C666_15040Rieske (2Fe-2S) domain-containing protein
C666_15055Rieske (2Fe-2S) domain-containing protein
Thermomicrobium roseumtrd_0121rieske 2Fe-2S domain protein
trd_A03413-phenylpropionate dioxygenase subunit alpha (Digoxigenin subunit alpha)
Thermotoga maritima100826TM_1340oxidase-related protein
Thermotoga naphthophila104846Tnap_1462Rieske (2Fe-2S) iron-sulphur domain protein
Thermotoga neapolitana107923CTN_1250Rieske (2Fe-2S) domain protein
Thermotoga petrophila104847Tpet_1442Rieske (2Fe-2S) domain protein
Vibrio alginolyticus15630N646_3147Rieske 2Fe-2S family protein