| accession | DB | alignment | Evalue | Score | Ident. | link | information | pubmed |
1
|
Q9F835_9ACTO (Q9F835) |
|
|
1e-110 |
402 |
100% |
|
- Product
- TDP-4-keto-6-deoxyhexose 3,5-epimerase
- Gene
- megDIV
- Organism
- Micromonospora megalomicea subsp. nigra
|
1uniprot[Pubmed] 10972798 [Medline] 20430101 Biosynthesis of the anti-parasitic agent megalomicin: transformation of erythromycin to megalomicin in Saccharopolyspora erythraea.(Mol. Microbiol.) [2000] |
|
2
|
F2RC34_STRVP (F2RC34) |
|
|
1e-59 |
233 |
58% |
|
- Product
- dTDP-4-dehydrorhamnose 3,5-epimerase
- Gene
- SVEN_5999
- Organism
- Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
|
1uniprot[Pubmed] 21463507 Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes.(BMC Genomics) [2011] |
|
3
|
O33707_STRPE (O33707) |
|
|
4e-58 |
228 |
56% |
|
- Product
- Putative epimerase
- Gene
- dnmU
- Organism
- Streptomyces peucetius
|
1uniprot[Pubmed] 9209071 [Medline] 97352712 Cloning and characterization of the Streptomyces peucetius dnmZUV genes encoding three enzymes required for biosynthesis of the daunorubicin precursor thymidine diphospho-L-daunosamine.(J. Bacteriol.) [1997] |
|
8
|
Q54198_STRGR (Q54198) |
|
|
2e-55 |
219 |
54% |
|
- Product
- DNA sequence for ORF's 1-6
- Gene
-
- Organism
- Streptomyces griseus
|
1uniprot[Pubmed] 8232204 [Medline] 94049680 Nucleotide sequence analysis of five putative Streptomyces griseus genes, one of which complements an early function in daunorubicin biosynthesis that is linked to a putative gene cluster involved in TDP-daunosamine formation.(Mol. Gen. Genet.) [1993] |
|
9
|
D5SL03_STRCL (D5SL03) |
|
|
3e-55 |
218 |
56% |
|
- Product
- Staurosporine biosynthesis 3,5-epimerase StaE
- Gene
- staE
SCLAV_p1110
- Organism
- Streptomyces clavuligerus ATCC 27064
|
1uniprot The sequence of a 1.8 Mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.(Genome Biol. Evol.) [2010] |
|
10
|
Q9L556_9ACTO (Q9L556) |
|
|
1e-54 |
216 |
54% |
|
- Product
- AknL
- Gene
- aknL
- Organism
- Streptomyces galilaeus
|
1uniprot[Pubmed] 12137949 [Medline] 22133312 Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster.(Gene) [2002] |
|
11
|
E9L1H0_9ZZZZ (E9L1H0) |
|
|
2e-54 |
216 |
53% |
|
- Product
- Putative uncharacterized protein
- Gene
- CA37-26
- Organism
- uncultured organism CA37
|
1uniprot[Pubmed] 20945895 Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010] |
|
12
|
Q83X58_STRRO (Q83X58) |
|
|
2e-54 |
216 |
57% |
|
- Product
- Putative NDP-4-keto-6-deoxyhexose 3,5-epimerase
- Gene
- lkmBVII
- Organism
- Streptomyces rochei
Streptomyces parvullus
|
1uniprot[Pubmed] 12791134 [Medline] 22676866 The large linear plasmid pSLA2-L of Streptomyces rochei has an unusually condensed gene organization for secondary metabolism.(Mol. Microbiol.) [2003] | 2uniprot[Pubmed] 10954087 [Medline] 20408175 Cloning and analysis of the replication origin and the telomeres of the large linear plasmid pSLA2-L in Streptomyces rochei.(Mol. Gen. Genet.) [2000] | 3uniprot[Pubmed] 10767533 [Medline] 20231737 Identification of two polyketide synthase gene clusters on the linear plasmid pSLA2-L in Streptomyces rochei.(Gene) [2000] | 4uniprot[Pubmed] 9836424 [Medline] 99053144 Physical mapping of the linear plasmid pSLA2-L and localization of the eryAI and actI homologs.(Biosci. Biotechnol. Biochem.) [1998] | [pubmed all]
|
13
|
Q939X4_9PSEU (Q939X4) |
|
|
7e-54 |
214 |
54% |
|
- Product
- Putative 3,5 epimerase
- Gene
- dvaD
- Organism
- Amycolatopsis balhimycina
|
1uniprot[Pubmed] 10390204 [Medline] 99318579 Identification and analysis of the balhimycin biosynthetic gene cluster and its use for manipulating glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908.(Antimicrob. Agents Chemother.) [1999] | 2uniprot[Pubmed] 11932455 [Medline] 21930292 Nonribosomal biosynthesis of vancomycin-type antibiotics: a heptapeptide backbone and eight peptide synthetase modules.(Microbiology) [2002] | 3uniprot[Pubmed] 11495926 [Medline] 21486455 A polyketide synthase in glycopeptide biosynthesis: the biosynthesis of the non-proteinogenic amino acid (S)-3,5-dihydroxyphenylglycine.(J. Biol. Chem.) [2001] | 4uniprot[Pubmed] 12404385 The biosynthesis of vancomycin-type glycopeptide antibiotics - the order of cyclization steps.(Angew. Chem. Int. Ed. Engl.) [2001] | 5uniprot[Pubmed] 11880037 [Medline] 21869276 Glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908: function of a halogenase and a haloperoxidase/perhydrolase.(Chem. Biol.) [2002] | 6uniprot Precursor-directed biosynthesis for the generation of novel glycopetides.(Ernst Schering Res. Found. Workshop) [2005] | [pubmed all]
|
14
|
Q83WF8_9ACTO (Q83WF8) |
|
|
8e-54 |
214 |
55% |
|
- Product
- 3,5-epimerase
- Gene
- staE
- Organism
- Streptomyces sp. TP-A0274
|
1uniprot Direct formation of chromopyrrolic acid from indole-3-pyruvic acid by StaD, a novel hemoprotein in indolocarbazole biosynthesis.(Tetrahedron Lett.) [2006] | 2uniprot Biosynthesis of heterocyclic antibiotics in actinomycetes and an approach to synthesize the natural compounds.(Nihon Hosenkin Gakkaishi) [2006] | 3uniprot[Pubmed] 12617516 [Medline] 22504382 Cloning of the staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274 and its heterologous expression in Streptomyces lividans.(J. Antibiot.) [2002] | 4uniprot Characterization of the biosynthetic gene cluster of rebecamycin from Lechevalieria aerocolonigenes ATCC 39243.(Biosci. Biotechnol. Biochem.) [2003] | 5uniprot[Pubmed] 16195595 Cytochrome P450 homolog is responsible for C-N bond formation between aglycone and deoxysugar in the staurosporine biosynthesis of Streptomyces sp. TP-A0274.(Biosci. Biotechnol. Biochem.) [2005] | [pubmed all]
|
15
|
Q8VWB8_9ACTO (Q8VWB8) |
|
|
9e-54 |
214 |
53% |
|
- Product
- AclL
- Gene
- aclL
- Organism
- Streptomyces galilaeus
|
1uniprot[Pubmed] 12399480 [Medline] 22286521 Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus.(J. Bacteriol.) [2002] |
|
16
|
Q9S0P2_STRAW (Q9S0P2) |
|
|
1e-52 |
210 |
56% |
|
- Product
- dTDP-4-keto-6-deoxyhexose 3,5-epimerase
- Gene
- aveBV
SAV949 SAV_949
- Organism
- Streptomyces avermitilis
|
1uniprot[Pubmed] 10449723 [Medline] 99380548 Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis.(Proc. Natl. Acad. Sci. U.S.A.) [1999] | 2uniprot[Pubmed] 11572948 [Medline] 21477403 Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.(Proc. Natl. Acad. Sci. U.S.A.) [2001] | 3uniprot[Pubmed] 12692562 [Medline] 22608306 Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis.(Nat. Biotechnol.) [2003] | [pubmed all]
|
17
|
E9L1R7_9ZZZZ (E9L1R7) |
|
|
1e-52 |
210 |
52% |
|
- Product
- Putative uncharacterized protein
- Gene
- CA915-25
- Organism
- uncultured organism CA915
|
1uniprot[Pubmed] 20945895 Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010] |
|
19
|
B7T1A7_9BACT (B7T1A7) |
|
|
2e-52 |
209 |
51% |
|
- Product
- Veg35
- Gene
- veg35
- Organism
- uncultured soil bacterium
|
1uniprot[Pubmed] 18987322 Cloning and characterization of new glycopeptide gene clusters found in an environmental DNA megalibrary.(Proc. Natl. Acad. Sci. U.S.A.) [2008] |
|
20
|
D9UBP2_STRPR (D9UBP2) |
|
|
2e-52 |
209 |
56% |
|
- Product
- Putative dTDP-4-deoxyglucose 3,5-epimerase
- Gene
- c101_15
- Organism
- Streptomyces pristinaespiralis
|
1uniprot[Pubmed] 21342465 Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011] |
|
21
|
E9L1N7_9ZZZZ (E9L1N7) |
|
|
9e-52 |
207 |
53% |
|
- Product
- Putative uncharacterized protein
- Gene
- CA878-38
- Organism
- uncultured organism CA878
|
1uniprot[Pubmed] 20945895 Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010] |
|
24
|
O52806_AMYOR (O52806) |
|
|
5e-51 |
204 |
51% |
|
- Product
- PCZA361.16
- Gene
-
- Organism
- Amycolatopsis orientalis
Nocardia orientalis
|
1uniprot[Pubmed] 9545426 [Medline] 98212597 Sequencing and analysis of genes involved in the biosynthesis of a vancomycin group antibiotic.(Chem. Biol.) [1998] | 2uniprot[Pubmed] 12077451 [Medline] 22071429 Purification, crystallization and preliminary structural studies of dTDP-4-keto-6-deoxy-glucose-5-epimerase (EvaD) from Amycolatopsis orientalis, the fourth enzyme in the dTDP-L-epivancosamine biosynthetic pathway.(Acta Crystallogr. D Biol. Crystallogr.) [2002] | 3uniprot[Pubmed] 15159413 The position of a key tyrosine in dTDP-4-Keto-6-deoxy-D-glucose-5-epimerase (EvaD) alters the substrate profile for this RmlC-like enzyme.(J. Biol. Chem.) [2004] | [pubmed all]
|
26
|
C0JWD5_9ACTO (C0JWD5) |
|
|
1e-50 |
203 |
53% |
|
- Product
- PokS7
- Gene
- pokS7
- Organism
- Streptomyces diastatochromogenes
|
1uniprot[Pubmed] 19266534 Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009] |
|
27
|
A4F7N1_SACEN (A4F7N1) |
|
|
4e-50 |
201 |
53% |
|
- Product
- DTDP-4-deoxyglucose 3,5-epimerase
- Gene
- eryBVII
SACE_0714
- Organism
- Saccharopolyspora erythraea (strain NRRL 23338)
|
1uniprot[Pubmed] 17369815 Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007] |
|
28
|
O54257_STRNO (O54257) |
|
|
9e-50 |
200 |
51% |
|
- Product
- SnogF
- Gene
- snogF
- Organism
- Streptomyces nogalater
|
1uniprot[Pubmed] 8668120 [Medline] 96242142 A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.(Mol. Gen. Genet.) [1996] | 2uniprot[Pubmed] 9349712 [Medline] 98007868 Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.(Mol. Gen. Genet.) [1997] | 3uniprot[Pubmed] 8760909 [Medline] 96349102 Production of hybrid anthracycline antibiotics by heterologous expression of Streptomyces nogalater nogalamycin biosynthesis genes.(Microbiology) [1996] | [pubmed all]
|
29
|
Q2PZS4_9ACTO (Q2PZS4) |
|
|
6e-49 |
197 |
50% |
|
- Product
- CosL
- Gene
- cosL
- Organism
- Streptomyces olindensis
|
1uniprot[Pubmed] 16810496 Insights in the glycosylation steps during biosynthesis of the antitumor anthracycline cosmomycin: characterization of two glycosyltransferase genes.(Appl. Microbiol. Biotechnol.) [2006] |
|
30
|
B1VRP0_STRGG (B1VRP0) |
|
|
4e-48 |
195 |
53% |
|
- Product
- Putative epimerase
- Gene
- SGR_629
- Organism
- Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
|
1uniprot[Pubmed] 18375553 Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350.(J. Bacteriol.) [2008] |
|
31
|
Q04793_SACER (Q04793) |
|
|
3e-47 |
192 |
53% |
|
- Product
- EryBVII
Putative TDP-4-keto-6-deoxyglucose 3,5 epimerase or 5-epimerase
- Gene
- eryBVII
EryBVII
- Organism
- Saccharopolyspora erythraea
Streptomyces erythraeus
|
1uniprot[Pubmed] 9353926 [Medline] 98015410 Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production.(Microbiology) | 2uniprot[Pubmed] 9393448 [Medline] 98055166 Analysis of seven genes from the eryAI-eryK region of the erythromycin biosynthetic gene cluster in Saccharopolyspora erythraea.(Mol. Gen. Genet.) [1997] | [pubmed all]
|
32
|
D8HRG7_AMYMU (D8HRG7) |
|
|
1e-46 |
190 |
49% |
|
- Product
- dTDP-4-dehydrorhamnose 3,5-epimerase
- Gene
- rfbC
AMED_7962
- Organism
- Amycolatopsis mediterranei (strain U-32)
|
1uniprot[Pubmed] 20567260 Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010] |
|
33
|
Q939Q4_9ACTO (Q939Q4) |
|
|
2e-46 |
189 |
51% |
|
- Product
- NDP-4-keto-6-deoxyhexose 5-epimerase
- Gene
- jadU
- Organism
- Streptomyces venezuelae
|
1uniprot[Pubmed] 11932454 [Medline] 21930291 Biosynthesis of the dideoxysugar component of jadomycin B: genes in the jad cluster of Streptomyces venezuelae ISP5230 for L-digitoxose assembly and transfer to the angucycline aglycone.(Microbiology) [2002] |
|
36
|
Q67G39_9ACTO (Q67G39) |
|
|
4e-46 |
188 |
52% |
|
- Product
- Putative 3-5-epimerase
- Gene
-
- Organism
- Streptomyces griseoruber
|
1uniprot[Pubmed] 15271354 The hedamycin locus implicates a novel aromatic PKS priming mechanism.(Chem. Biol.) [2004] |
|
37
|
C7MXW1_SACVD (C7MXW1) |
|
|
5e-46 |
188 |
48% |
|
- Product
- dTDP-4-dehydrorhamnose 3,5-epimerase
- Gene
- Svir_30640
- Organism
- Saccharomonospora viridis (strain ATCC 15386 / DSM 43017 / JCM 3036 / NBRC 12207 / P101)
|
1uniprot Complete genome sequence of Saccharomonospora viridis type strain (P101T).(Stand. Genomic Sci.) [2009] |
|
38
|
Q93EK2_9PSEU (Q93EK2) |
|
|
7e-46 |
187 |
50% |
|
- Product
- Putative TDP-4-keto-6-deoxyglucose 3,5 epimerase
- Gene
- epi
- Organism
- Saccharopolyspora spinosa
|
1uniprot[Pubmed] 11544225 [Medline] 21429236 Rhamnose biosynthesis pathway supplies precursors for primary and secondary metabolism in Saccharopolyspora spinosa.(J. Bacteriol.) [2001] |
|
44
|
D1A6T2_THECD (D1A6T2) |
|
|
4e-45 |
185 |
50% |
|
- Product
- dTDP-4-dehydrorhamnose 3,5-epimerase
- Gene
- Tcur_2791
- Organism
- Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
|
1uniprot Complete genome sequence of Thermomonospora curvata type strain (B9).(Stand. Genomic Sci.) [2011] |
|
50
|
A4FNG1_SACEN (A4FNG1) |
|
|
5e-44 |
181 |
49% |
|
- Product
- DTDP-4-dehydrorhamnose 3,5-epimerase
- Gene
- rmlC
SACE_6416
- Organism
- Saccharopolyspora erythraea (strain NRRL 23338)
|
1uniprot[Pubmed] 17369815 Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007] |
|
52
|
C6WJ08_ACTMD (C6WJ08) |
|
|
8e-44 |
181 |
52% |
|
- Product
- dTDP-4-dehydrorhamnose 3,5-epimerase
- Gene
- Amir_6280
- Organism
- Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971)
|
1uniprot Complete genome sequence of Actinosynnema mirum type strain (101).(Stand. Genomic Sci.) [2009] |
|
53
|
A8KQL7_9ACTO (A8KQL7) |
|
|
1e-43 |
180 |
47% |
|
- Product
- 3,5-epimerase
- Gene
- rhaC
- Organism
- Streptomyces olivaceus
|
1uniprot[Pubmed] 18310024 Biosynthesis of elloramycin in Streptomyces olivaceus requires glycosylation by enzymes encoded outside the aglycon cluster.(Microbiology) [2008] |
|
54
|
Q2J6I9_FRASC (Q2J6I9) |
|
|
1e-43 |
180 |
46% |
|
- Product
- dTDP-4-dehydrorhamnose 3,5-epimerase
- Gene
- Francci3_3752
- Organism
- Frankia sp. (strain CcI3)
|
1uniprot[Pubmed] 17151343 Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007] |
|
55
|
Q8GHA6_9ACTO (Q8GHA6) |
|
|
3e-43 |
179 |
50% |
|
- Product
- DTDP-4-keto-6-deoxyglucose 3,5-epimerase
- Gene
- cloW
- Organism
- Streptomyces roseochromogenes subsp. oscitans
|
1uniprot[Pubmed] 12480894 [Medline] 22368916 Molecular cloning and sequence analysis of the clorobiocin biosynthetic gene cluster: new insights into the biosynthesis of aminocoumarin antibiotics.(Microbiology) [2002] |
|
60
|
Q5Y9I2_9ACTO (Q5Y9I2) |
|
|
1e-42 |
176 |
50% |
|
- Product
- DTDP-4-keto-6-deoxyglucose 3,5-epimerase
- Gene
- eryBVII
- Organism
- Aeromicrobium erythreum
|
1uniprot[Pubmed] 15257441 The erythromycin biosynthetic gene cluster of Aeromicrobium erythreum.(J. Ind. Microbiol. Biotechnol.) [2004] |
|
61
|
Q0RD59_FRAAA (Q0RD59) |
|
|
3e-42 |
176 |
46% |
|
- Product
- dTDP-4-dehydrorhamnose 3,5-epimerase (DTDP-4-keto-6-deoxyglucose 3,5-epimerase) (DTDP-L-rhamnose synthetase)
- Gene
- rfbC
FRAAL5989
- Organism
- Frankia alni (strain ACN14a)
|
1uniprot[Pubmed] 17151343 Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007] |
|
66
|
Q9L9E5_STRSH (Q9L9E5) |
|
|
1e-41 |
174 |
50% |
|
- Product
- NovW
- Gene
- novW
- Organism
- Streptomyces spheroides
Streptomyces caeruleus
|
1uniprot[Pubmed] 10770754 [Medline] 20233587 Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891.(Antimicrob. Agents Chemother.) [2000] | 2uniprot[Pubmed] 16411240 The 1.6-A resolution crystal structure of NovW: a 4-keto-6-deoxy sugar epimerase from the novobiocin biosynthetic gene cluster of Streptomyces spheroides.(Proteins) [2006] | [pubmed all]
|
67
|
A3TML8_9MICO (A3TML8) |
|
|
1e-41 |
173 |
46% |
|
- Product
- dTDP-4-dehydrorhamnose 3,5-epimerase
- Gene
- JNB_05605
- Organism
- Janibacter sp. HTCC2649
|
1uniprot[Pubmed] 21075932 Genome sequence of the Marine Janibacter Sp. Strain HTCC2649.(J. Bacteriol.) [2011] |
|
71
|
Q7BUE0_AMYMD (Q7BUE0) |
|
|
2e-41 |
172 |
48% |
|
- Product
- Putative dNTP-hexose 3,5-epimerase
- Gene
-
- Organism
- Amycolatopsis mediterranei
Nocardia mediterranei
|
1uniprot[Pubmed] 9512878 [Medline] 98174059 Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699.(Chem. Biol.) [1998] | 2uniprot[Pubmed] 9497318 [Medline] 98165773 3-amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the formation of the precursor of mC7N units in rifamycin and related antibiotics.(J. Biol. Chem.) [1998] | 3uniprot[Pubmed] 11278540 [Medline] 21201076 Mutational analysis and reconstituted expression of the biosynthetic genes involved in the formation of 3-amino-5-hydroxybenzoic acid, the starter unit of rifamycin biosynthesis in amycolatopsis Mediterranei S699.(J. Biol. Chem.) [2001] | [pubmed all]
|
72
|
D8HZA5_AMYMU (D8HZA5) |
|
|
3e-41 |
172 |
48% |
|
- Product
- dTDP-4-dehydrorhamnose 3,5-epimerase
- Gene
- rfbC
AMED_0640
- Organism
- Amycolatopsis mediterranei (strain U-32)
|
1uniprot[Pubmed] 20567260 Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010] |
|
73
|
O52564_AMYMD (O52564) |
|
|
3e-41 |
172 |
48% |
|
- Product
- DNTP-hexose 3,5 epimerase
- Gene
-
- Organism
- Amycolatopsis mediterranei
Nocardia mediterranei
|
1uniprot[Pubmed] 9512878 [Medline] 98174059 Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699.(Chem. Biol.) [1998] | 2uniprot[Pubmed] 9497318 [Medline] 98165773 3-amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the formation of the precursor of mC7N units in rifamycin and related antibiotics.(J. Biol. Chem.) [1998] | 3uniprot[Pubmed] 11278540 [Medline] 21201076 Mutational analysis and reconstituted expression of the biosynthetic genes involved in the formation of 3-amino-5-hydroxybenzoic acid, the starter unit of rifamycin biosynthesis in amycolatopsis Mediterranei S699.(J. Biol. Chem.) [2001] | [pubmed all]
|
74
|
D9I0H7_9ACTO (D9I0H7) |
|
|
3e-41 |
172 |
46% |
|
- Product
- Sugar 3,5-epimerase
- Gene
- cpzDVI
- Organism
- Streptomyces sp. MK730-62F2
|
1uniprot[Pubmed] 20418426 Formation and attachment of the deoxysugar moiety and assembly of the gene cluster for caprazamycin biosynthesis.(Appl. Environ. Microbiol.) [2010] |
|
77
|
Q331R1_9ACTO (Q331R1) |
|
|
5e-41 |
171 |
46% |
|
- Product
- NDP-hexose-3-epimerase
- Gene
- gerF
- Organism
- Streptomyces sp. KCTC 0041BP
|
1uniprot[Pubmed] 17053005 Biosynthesis of dTDP-6-deoxy-beta-D-allose, biochemical characterization of dTDP-4-keto-6-deoxyglucose reductase (GerKI) from Streptomyces sp. KCTC 0041BP.(Glycobiology) [2007] | 2uniprot Cloning and characterization of a gene cluster for the production of the polyketide macrolide antibiotic dihydrochalcomycin in Streptomyces sp. KCTC 0041BP.(J. Microbiol. Biotechnol.) [2006] |
|
79
|
Q9L6C5_STRAT (Q9L6C5) |
|
|
1e-40 |
170 |
48% |
|
- Product
- DTDP-4-keto-6-deoxyglucose 3,5-epimerase
- Gene
-
- Organism
- Streptomyces antibioticus
|
1uniprot Mechanism of the 2-deoxygenation step in the biosynthesis of the deoxyhexose moieties of the antibiotics granaticin and oleandomycin.(J. Am. Chem. Soc.) [1999] |
|
80
|
C7QIW8_CATAD (C7QIW8) |
|
|
3e-40 |
169 |
46% |
|
- Product
- dTDP-4-dehydrorhamnose 3,5-epimerase
- Gene
- Caci_8195
- Organism
- Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
|
1uniprot Complete genome sequence of Catenulispora acidiphila type strain (ID 139908).(Stand. Genomic Sci.) [2009] |
|
83
|
D2B4H1_STRRD (D2B4H1) |
|
|
7e-40 |
167 |
46% |
|
- Product
- dTDP-4-dehydrorhamnose 3,5-epimerase
- Gene
- Sros_0634
- Organism
- Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
|
1uniprot Complete genome sequence of Streptosporangium roseum type strain (NI 9100T).(Stand. Genomic Sci.) [2010] |
|
84
|
Q5SFD1_STRBI (Q5SFD1) |
|
|
9e-40 |
167 |
46% |
|
- Product
- Putative 3-epimerase in D-allose pathway
- Gene
- chmJ
- Organism
- Streptomyces bikiniensis
|
1uniprot[Pubmed] 15561847 Chalcomycin biosynthesis gene cluster from Streptomyces bikiniensis: novel features of an unusual ketolide produced through expression of the chm polyketide synthase in Streptomyces fradiae.(Antimicrob. Agents Chemother.) [2004] |
|
85
|
A8L2P2_FRASN (A8L2P2) |
|
|
1e-39 |
167 |
46% |
|
- Product
- dTDP-4-dehydrorhamnose 3,5-epimerase
- Gene
- Franean1_0979
- Organism
- Frankia sp. (strain EAN1pec)
|
1uniprot[Pubmed] 17151343 Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007] |
|
89
|
Q52V56_9ACTO (Q52V56) |
|
|
2e-39 |
166 |
46% |
|
- Product
- Sugar epimerase
- Gene
-
- Organism
- Streptomyces aizunensis
|
1uniprot[Pubmed] 15844935 Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example.(J. Nat. Prod.) [2005] |
|
94
|
E4WBT5_RHOE1 (E4WBT5) |
|
|
1e-38 |
163 |
43% |
|
- Product
- dTDP-4-dehydrorhamnose 3,5-epimerase RmlC
- Gene
- rmlC
REQ_02380
- Organism
- Rhodococcus equi (strain 103S)
Corynebacterium equi
|
1uniprot[Pubmed] 20941392 The genome of a pathogenic rhodococcus: cooptive virulence underpinned by key gene acquisitions.(PLoS Genet.) [2010] |
|
95
|
Q9F8S7_9ACTO (Q9F8S7) |
|
|
1e-38 |
163 |
51% |
|
- Product
- DTDP-4-keto-6-deoxyglucose 3,5-epimerase
- Gene
- couW
- Organism
- Streptomyces rishiriensis
|
1uniprot[Pubmed] 11036020 [Medline] 20493109 Identification of the coumermycin A(1) biosynthetic gene cluster of Streptomyces rishiriensis DSM 40489.(Antimicrob. Agents Chemother.) [2000] |
|
96
|
D5UHC0_CELFN (D5UHC0) |
|
|
1e-38 |
163 |
45% |
|
- Product
- dTDP-4-dehydrorhamnose 3,5-epimerase
- Gene
- Cfla_2351
- Organism
- Cellulomonas flavigena (strain ATCC 482 / DSM 20109 / NCIB 8073 / NRS 134)
|
1uniprot Complete genome sequence of Cellulomonas flavigena type strain (134).(Stand. Genomic Sci.) [2010] |
|
98
|
Q54265_STRGA (Q54265) |
|
|
3e-38 |
162 |
46% |
|
- Product
- DTDP-4-keto-6-deoxyglucose 3,5-epimerase
StrM
- Gene
- strM
- Organism
- Streptomyces glaucescens
|
1uniprot[Pubmed] 8628239 [Medline] 96204519 The str gene cluster for the biosynthesis of 5'-hydroxystreptomycin in Streptomyces glaucescens GLA.0 (ETH 22794): new operons and evidence for pathway-specific regulation by StrR.(Mol. Gen. Genet.) [1996] | 2uniprot Streptomycin Production in Streptomycetes: a Progress Report.(INDUSTRIAL MICROORGANISMS. BASIC AND APPLIED MOLECULAR GENETICS) [1993] |
|