| accession | DB | alignment | Evalue | Score | Ident. | link | information | pubmed |
2
|
Q4R0L9_STRCX (Q4R0L9) |
|
|
7e-65 |
252 |
44% |
|
- Product
- ChaGT1 protein
- Gene
- chaGT1
- Organism
- Streptomyces chartreusis
|
1uniprot[Pubmed] 15911378 Biosynthesis of the antitumor agent chartreusin involves the oxidative rearrangement of an anthracyclic polyketide.(Chem. Biol.) [2005] |
|
3
|
Q67G38_9ACTO (Q67G38) |
|
|
1e-63 |
248 |
45% |
|
- Product
- Glycosyltransferase
- Gene
-
- Organism
- Streptomyces griseoruber
|
1uniprot[Pubmed] 15271354 The hedamycin locus implicates a novel aromatic PKS priming mechanism.(Chem. Biol.) [2004] |
|
4
|
D1A6T1_THECD (D1A6T1) |
|
|
5e-63 |
246 |
42% |
|
- Product
- Putative uncharacterized protein
- Gene
- Tcur_2790
- Organism
- Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
|
1uniprot Complete genome sequence of Thermomonospora curvata type strain (B9).(Stand. Genomic Sci.) [2011] |
|
5
|
Q194P6_STRAA (Q194P6) |
|
|
3e-61 |
240 |
44% |
|
- Product
- Glycosyltransferase
- Gene
- mtmGII
- Organism
- Streptomyces argillaceus
|
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996] | 2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996] | 3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997] | 4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998] | 5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999] | 6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999] | 7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000] | 8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001] | 9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003] | 10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999] | 11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002] | 12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000] | 13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000] | 14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002] | 15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003] | 16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996] | 17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004] | 18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997] | 19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005] | 20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000] | [pubmed all]
|
6
|
D6MSX4_9ACTO (D6MSX4) |
|
|
1e-58 |
231 |
39% |
|
- Product
- SsfS6
- Gene
- ssfS6
- Organism
- Streptomyces sp. SF2575
|
1uniprot[Pubmed] 19908837 Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.(J. Am. Chem. Soc.) [2009] |
|
8
|
Q9L9F5_STRSH (Q9L9F5) |
|
|
2e-53 |
214 |
41% |
|
- Product
- NovM
- Gene
- novM
- Organism
- Streptomyces spheroides
Streptomyces caeruleus
|
1uniprot[Pubmed] 10770754 [Medline] 20233587 Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891.(Antimicrob. Agents Chemother.) [2000] |
|
10
|
A8Y8I2_STRAM (A8Y8I2) |
|
|
3e-53 |
214 |
42% |
|
- Product
- Putative glycosyltransferase
- Gene
- srm18
- Organism
- Streptomyces ambofaciens
|
1uniprot Organization of the biosynthetic gene cluster for the macrolide antibiotic spiramycin in Streptomyces ambofaciens.(Microbiology (Mosc.)) [2007] |
|
11
|
Q8GHC2_9ACTO (Q8GHC2) |
|
|
5e-51 |
206 |
40% |
|
- Product
- Glycosyltransferase
- Gene
- cloM
- Organism
- Streptomyces roseochromogenes subsp. oscitans
|
1uniprot[Pubmed] 12480894 [Medline] 22368916 Molecular cloning and sequence analysis of the clorobiocin biosynthetic gene cluster: new insights into the biosynthesis of aminocoumarin antibiotics.(Microbiology) [2002] |
|
13
|
Q9F8U7_9ACTO (Q9F8U7) |
|
|
9e-51 |
205 |
40% |
|
- Product
- Glycosyl transferase
- Gene
- couM
- Organism
- Streptomyces rishiriensis
|
1uniprot[Pubmed] 11036020 [Medline] 20493109 Identification of the coumermycin A(1) biosynthetic gene cluster of Streptomyces rishiriensis DSM 40489.(Antimicrob. Agents Chemother.) [2000] |
|
14
|
Q67G44_9ACTO (Q67G44) |
|
|
2e-50 |
204 |
40% |
|
- Product
- Glycosyltransferase
- Gene
-
- Organism
- Streptomyces griseoruber
|
1uniprot[Pubmed] 15271354 The hedamycin locus implicates a novel aromatic PKS priming mechanism.(Chem. Biol.) [2004] |
|
15
|
Q9ZA43_STRVN (Q9ZA43) |
|
|
1e-49 |
202 |
36% |
|
- Product
- Putative glycosyl transferase
- Gene
- gra-orf14
- Organism
- Streptomyces violaceoruber
|
1uniprot[Pubmed] 2583128 [Medline] 90060034 Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber Tu22.(EMBO J.) [1989] | 2uniprot[Pubmed] 7476861 [Medline] 96027933 Identification of Streptomyces violaceoruber Tu22 genes involved in the biosynthesis of granaticin.(Mol. Gen. Genet.) [1995] | 3uniprot[Pubmed] 9831526 [Medline] 99051446 The granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tu22: sequence analysis and expression in a heterologous host.(Chem. Biol.) [1998] | [pubmed all]
|
16
|
D8I4K4_AMYMU (D8I4K4) |
|
|
7e-49 |
199 |
36% |
|
- Product
- Putative glycosyl transferase
- Gene
- AMED_5418
- Organism
- Amycolatopsis mediterranei (strain U-32)
|
1uniprot[Pubmed] 20567260 Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010] |
|
17
|
A4GV89_9ACTO (A4GV89) |
|
|
5e-47 |
193 |
36% |
|
- Product
- Glycosyltransferase
- Gene
- holN
- Organism
- Streptomyces sp. FU107
|
1uniprot[Pubmed] 17497146 A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007] |
|
18
|
A4FK43_SACEN (A4FK43) |
|
|
2e-45 |
187 |
38% |
|
- Product
- Putative glycosyl transferase, related to UDP-glucuronosyltransferase
- Gene
- iroB
SACE_5174
- Organism
- Saccharopolyspora erythraea (strain NRRL 23338)
|
1uniprot[Pubmed] 17369815 Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007] |
|
19
|
Q7WT14_9ACTO (Q7WT14) |
|
|
3e-45 |
187 |
37% |
|
- Product
- C-glycosyl transferase
- Gene
- med-ORF8
- Organism
- Streptomyces sp. AM-7161
|
1uniprot Cloning, sequencing and heterologous expression of the medermycin biosynthetic gene cluster of Streptomyces sp. AM-7161: towards comparative analysis of the benzoisochromanequione gene clusters.(Microbiology (Mosc.)) [2003] |
|
21
|
D1GLU2_9ACTO (D1GLU2) |
|
|
2e-44 |
184 |
34% |
|
- Product
- Glycosyltransferase
- Gene
- slgG
- Organism
- Streptomyces lydicus
|
1uniprot Deciphering biosynthesis of the RNA polymerase inhibitor streptolydigin and generation of glycosylated derivatives.(Chem. Biol.) [2009] |
|
22
|
Q9RPA1_STRFR (Q9RPA1) |
|
|
3e-44 |
184 |
40% |
|
- Product
- Glycosyl transferase
- Gene
- urdGT1b
- Organism
- Streptomyces fradiae
Streptomyces roseoflavus
|
1uniprot[Pubmed] 10658661 [Medline] 20121748 Two new tailoring enzymes, a glycosyltransferase and an oxygenase, involved in biosynthesis of the angucycline antibiotic urdamycin A in Streptomyces fradiae Tu2717.(Microbiology) [2000] |
|
23
|
B5L6J8_MICCH (B5L6J8) |
|
|
4e-44 |
183 |
36% |
|
- Product
- Glycosyltransferase
- Gene
-
- Organism
- Micromonospora chalcea
|
1uniprot[Pubmed] 18586939 Cloning and characterization of the tetrocarcin A gene cluster from Micromonospora chalcea NRRL 11289 reveals a highly conserved strategy for tetronate biosynthesis in spirotetronate antibiotics.(J. Bacteriol.) [2008] |
|
24
|
D4QF41_9ACTO (D4QF41) |
|
|
2e-43 |
181 |
36% |
|
- Product
- Rhamnosyltransferase
- Gene
- lipB1
- Organism
- Streptomyces sp. SANK 60405
|
1uniprot[Pubmed] 20043306 The biosynthesis of liposidomycin-like A-90289 antibiotics featuring a new type of sulfotransferase.(Chembiochem) [2010] |
|
25
|
C4NCL8_9ACTO (C4NCL8) |
|
|
2e-43 |
181 |
37% |
|
- Product
- Rhamnosyltransferase
- Gene
- cpz31
- Organism
- Streptomyces sp. MK730-62F2
|
1uniprot[Pubmed] 19351877 Identification and manipulation of the caprazamycin gene cluster leads to new simplified liponucleoside antibiotics and gives insights into the biosynthetic pathway.(J. Biol. Chem.) [2009] |
|
26
|
A4F7H2_SACEN (A4F7H2) |
|
|
3e-43 |
180 |
38% |
|
- Product
- Putative glucosyltransferase
- Gene
- iroB
SACE_0652
- Organism
- Saccharopolyspora erythraea (strain NRRL 23338)
|
1uniprot[Pubmed] 17369815 Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007] |
|
27
|
D7BZS5_STRBB (D7BZS5) |
|
|
3e-43 |
180 |
36% |
|
- Product
- IroB
- Gene
- SBI_06860
- Organism
- Streptomyces bingchenggensis (strain BCW-1)
|
1uniprot[Pubmed] 20581206 Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010] |
|
28
|
Q2HR56_9ACTO (Q2HR56) |
|
|
4e-43 |
180 |
35% |
|
- Product
- Putative C-glycosyltransferase
- Gene
- schS7
- Organism
- Streptomyces sp. SCC 2136
|
1uniprot Angucyclines Sch 47554 and Sch 47555 from Streptomyces sp. SCC-2136: Cloning, Sequencing, and Characterization.(Mol. Cells) [2006] | 2uniprot Molecular cloning and characterization of biosynthetic genes cluster of Sch 47554 from Streptomyces sp. SCC 2136. [2004] |
|
30
|
Q9ZGC0_STRCY (Q9ZGC0) |
|
|
2e-42 |
177 |
36% |
|
- Product
- Glycosyl transferase homolog
- Gene
- lanGT2
- Organism
- Streptomyces cyanogenus
|
1uniprot[Pubmed] 9933932 [Medline] 99132695 Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin biosynthesis.(FEMS Microbiol. Lett.) [1999] |
|
31
|
C4NYL6_9ACTO (C4NYL6) |
|
|
5e-42 |
176 |
34% |
|
- Product
- SaqGT5
- Gene
- saqGT5
- Organism
- Micromonospora sp. Tu 6368
|
1uniprot[Pubmed] 17497146 A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007] | 2uniprot[Pubmed] 19384899 Cloning and sequencing of the biosynthetic gene cluster for saquayamycin z and galtamycin B and the elucidation of the assembly of their saccharide chains.(Chembiochem) [2009] | [pubmed all]
|
32
|
Q9RP99_STRFR (Q9RP99) |
|
|
9e-42 |
176 |
39% |
|
- Product
- Glycosyl transferase
- Gene
- urdGT1c
- Organism
- Streptomyces fradiae
Streptomyces roseoflavus
|
1uniprot[Pubmed] 10658661 [Medline] 20121748 Two new tailoring enzymes, a glycosyltransferase and an oxygenase, involved in biosynthesis of the angucycline antibiotic urdamycin A in Streptomyces fradiae Tu2717.(Microbiology) [2000] |
|
33
|
D8I4I4_AMYMU (D8I4I4) |
|
|
1e-41 |
175 |
34% |
|
- Product
- Putative glycosyl transferase
- Gene
- AMED_5398
- Organism
- Amycolatopsis mediterranei (strain U-32)
|
1uniprot[Pubmed] 20567260 Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010] |
|
34
|
O87831_STRAT (O87831) |
|
|
3e-41 |
174 |
34% |
|
- Product
- Glycosyltransferase
- Gene
- oleG2
- Organism
- Streptomyces antibioticus
|
1uniprot[Pubmed] 9749673 [Medline] 98420102 Analysis of a Streptomyces antibioticus chromosomal region involved in oleandomycin biosynthesis, which encodes two glycosyltransferases responsible for glycosylation of the macrolactone ring.(Mol. Gen. Genet.) [1998] |
|
36
|
Q2HR28_9ACTO (Q2HR28) |
|
|
9e-41 |
172 |
36% |
|
- Product
- Putative O-glycosyltransferase
- Gene
- schS9
- Organism
- Streptomyces sp. SCC 2136
|
1uniprot Angucyclines Sch 47554 and Sch 47555 from Streptomyces sp. SCC-2136: Cloning, Sequencing, and Characterization.(Mol. Cells) [2006] | 2uniprot Molecular cloning and characterization of biosynthetic genes cluster of Sch 47554 from Streptomyces sp. SCC 2136. [2004] |
|
37
|
D7BZR5_STRBB (D7BZR5) |
|
|
1e-40 |
172 |
36% |
|
- Product
- Glycosyl transferase, NDP-D-desosamine: 3-L-mycarosyl erythronolide B
- Gene
- SBI_06850
- Organism
- Streptomyces bingchenggensis (strain BCW-1)
|
1uniprot[Pubmed] 20581206 Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010] |
|
38
|
C0JWA0_9ACTO (C0JWA0) |
|
|
1e-40 |
172 |
37% |
|
- Product
- PokGT2
- Gene
- pokGT2
- Organism
- Streptomyces diastatochromogenes
|
1uniprot[Pubmed] 19266534 Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009] |
|
41
|
D8I4K0_AMYMU (D8I4K0) |
|
|
2e-40 |
171 |
34% |
|
- Product
- Putative glycosyl transferase
- Gene
- AMED_5414
- Organism
- Amycolatopsis mediterranei (strain U-32)
|
1uniprot[Pubmed] 20567260 Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010] |
|
43
|
Q0PY15_STRMY (Q0PY15) |
|
|
6e-40 |
169 |
35% |
|
- Product
- Glycosyltransferase
- Gene
- midI
- Organism
- Streptomyces mycarofaciens
|
1uniprot[Pubmed] 17342257 Cloning and characterization of genes encoded in dTDP-D-mycaminose biosynthetic pathway from a midecamycin-producing strain, Streptomyces mycarofaciens.(Acta Biochim. Biophys. Sin.) [2007] |
|
44
|
D1A6R8_THECD (D1A6R8) |
|
|
7e-40 |
169 |
35% |
|
- Product
- Putative uncharacterized protein
- Gene
- Tcur_2776
- Organism
- Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
|
1uniprot Complete genome sequence of Thermomonospora curvata type strain (B9).(Stand. Genomic Sci.) [2011] |
|
45
|
Q194Q0_STRAA (Q194Q0) |
|
|
8e-40 |
169 |
35% |
|
- Product
- Glycosyltransferase
- Gene
- mtmGIV
- Organism
- Streptomyces argillaceus
|
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996] | 2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996] | 3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997] | 4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998] | 5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999] | 6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999] | 7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000] | 8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001] | 9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003] | 10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999] | 11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002] | 12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000] | 13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000] | 14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002] | 15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003] | 16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996] | 17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004] | 18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997] | 19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005] | 20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000] | [pubmed all]
|
47
|
D8HZA4_AMYMU (D8HZA4) |
|
|
1e-39 |
168 |
32% |
|
- Product
- DNTP-hexose glycosyl transferase
- Gene
- AMED_0639
- Organism
- Amycolatopsis mediterranei (strain U-32)
|
1uniprot[Pubmed] 20567260 Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010] |
|
48
|
O52563_AMYMD (O52563) |
|
|
1e-39 |
168 |
32% |
|
- Product
- Putative dNTP-hexose glycosyltransferase
- Gene
-
- Organism
- Amycolatopsis mediterranei
Nocardia mediterranei
|
1uniprot[Pubmed] 9512878 [Medline] 98174059 Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699.(Chem. Biol.) [1998] | 2uniprot[Pubmed] 9497318 [Medline] 98165773 3-amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the formation of the precursor of mC7N units in rifamycin and related antibiotics.(J. Biol. Chem.) [1998] | 3uniprot[Pubmed] 11278540 [Medline] 21201076 Mutational analysis and reconstituted expression of the biosynthetic genes involved in the formation of 3-amino-5-hydroxybenzoic acid, the starter unit of rifamycin biosynthesis in amycolatopsis Mediterranei S699.(J. Biol. Chem.) [2001] | [pubmed all]
|
50
|
Q9ZGB8_STRCY (Q9ZGB8) |
|
|
1e-39 |
168 |
36% |
|
- Product
- Glycosyl transferase homolog
- Gene
- lanGT1
- Organism
- Streptomyces cyanogenus
|
1uniprot[Pubmed] 9933932 [Medline] 99132695 Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin biosynthesis.(FEMS Microbiol. Lett.) [1999] |
|
57
|
D9UBS0_STRPR (D9UBS0) |
|
|
3e-38 |
164 |
34% |
|
- Product
- Putative glycosyltransferase
- Gene
- cpp14
- Organism
- Streptomyces pristinaespiralis
|
1uniprot[Pubmed] 21342465 Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011] |
|
59
|
P95747_STRFR (P95747) |
|
|
4e-38 |
163 |
33% |
|
- Product
- Glycosyltransferase
- Gene
- tylMII(orf2*)
- Organism
- Streptomyces fradiae
Streptomyces roseoflavus
|
1uniprot[Pubmed] 9031628 [Medline] 97183662 Analysis of four tylosin biosynthetic genes from the tylLM region of Streptomyces fradiae.(Gene) [1997] |
|
60
|
D7BZR2_STRBB (D7BZR2) |
|
|
5e-38 |
163 |
35% |
|
- Product
- Glycosyl transferase, NDP-D-desosamine: 3-L-mycarosyl erythronolide B
- Gene
- SBI_06847
- Organism
- Streptomyces bingchenggensis (strain BCW-1)
|
1uniprot[Pubmed] 20581206 Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010] |
|
62
|
D7B014_NOCDD (D7B014) |
|
|
6e-38 |
163 |
33% |
|
- Product
- Putative uncharacterized protein
- Gene
- Ndas_4716
- Organism
- Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei
|
1uniprot Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010] |
|
63
|
C4NYL0_9ACTO (C4NYL0) |
|
|
9e-38 |
162 |
37% |
|
- Product
- SaqGT3
- Gene
- saqGT3
- Organism
- Micromonospora sp. Tu 6368
|
1uniprot[Pubmed] 17497146 A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007] | 2uniprot[Pubmed] 19384899 Cloning and sequencing of the biosynthetic gene cluster for saquayamycin z and galtamycin B and the elucidation of the assembly of their saccharide chains.(Chembiochem) [2009] | [pubmed all]
|
64
|
B5L6L8_MICCH (B5L6L8) |
|
|
1e-37 |
162 |
32% |
|
- Product
- Glycosyltransferase
- Gene
-
- Organism
- Micromonospora chalcea
|
1uniprot[Pubmed] 18586939 Cloning and characterization of the tetrocarcin A gene cluster from Micromonospora chalcea NRRL 11289 reveals a highly conserved strategy for tetronate biosynthesis in spirotetronate antibiotics.(J. Bacteriol.) [2008] |
|
65
|
Q0R4P9_STRAT (Q0R4P9) |
|
|
1e-37 |
162 |
34% |
|
- Product
- ChlC7
- Gene
-
- Organism
- Streptomyces antibioticus
|
1uniprot[Pubmed] 16793515 Genetic characterization of the chlorothricin gene cluster as a model for spirotetronate antibiotic biosynthesis.(Chem. Biol.) [2006] |
|
66
|
A4F7P3_SACEN (A4F7P3) |
|
|
1e-37 |
162 |
31% |
|
- Product
- Glycosyl transferase, NDP-D-desosamine : 3-L-mycarosyl erythronolide B
- Gene
- eryCIII
SACE_0726
- Organism
- Saccharopolyspora erythraea (strain NRRL 23338)
|
1uniprot[Pubmed] 17369815 Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007] |
|
68
|
D7BZS3_STRBB (D7BZS3) |
|
|
1e-37 |
162 |
35% |
|
- Product
- Glycosyl transferase, NDP-D-desosamine: 3-L-mycarosyl erythronolide B
- Gene
- SBI_06858
- Organism
- Streptomyces bingchenggensis (strain BCW-1)
|
1uniprot[Pubmed] 20581206 Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010] |
|
69
|
E1ARK6_STRAU (E1ARK6) |
|
|
2e-37 |
161 |
34% |
|
- Product
- Putative glycosyltransferase
- Gene
- sa46
- Organism
- Streptomyces aureofaciens
|
1uniprot[Pubmed] 21393365 The role of two SARP family transcriptional regulators in regulation of the auricin gene cluster in Streptomyces aureofaciens CCM 3239.(Microbiology) [2011] |
|
70
|
Q52V43_9ACTO (Q52V43) |
|
|
2e-37 |
161 |
36% |
|
- Product
- Glycosyltransferase
- Gene
-
- Organism
- Streptomyces aizunensis
|
1uniprot[Pubmed] 15844935 Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example.(J. Nat. Prod.) [2005] |
|
71
|
Q76KZ6_STRHA (Q76KZ6) |
|
|
2e-37 |
161 |
32% |
|
- Product
- Glycosyltransferase
- Gene
- vinC
- Organism
- Streptomyces halstedii
|
1uniprot[Pubmed] 15112997 Cloning, sequencing, and functional analysis of the biosynthetic gene cluster of macrolactam antibiotic vicenistatin in Streptomyces halstedii.(Chem. Biol.) [2004] |
|
72
|
C0JWA3_9ACTO (C0JWA3) |
|
|
2e-37 |
161 |
36% |
|
- Product
- PokGT1
- Gene
- pokGT1
- Organism
- Streptomyces diastatochromogenes
|
1uniprot[Pubmed] 19266534 Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009] |
|
73
|
A8Y8I1_STRAM (A8Y8I1) |
|
|
3e-37 |
160 |
33% |
|
- Product
- Probable glycosyltransferase
- Gene
- srm17
- Organism
- Streptomyces ambofaciens
|
1uniprot Organization of the biosynthetic gene cluster for the macrolide antibiotic spiramycin in Streptomyces ambofaciens.(Microbiology (Mosc.)) [2007] |
|
74
|
A8Y8F5_STRAM (A8Y8F5) |
|
|
3e-37 |
160 |
35% |
|
- Product
- Probable glycosyltransferase
- Gene
- srm3*c
- Organism
- Streptomyces ambofaciens
|
1uniprot Organization of the biosynthetic gene cluster for the macrolide antibiotic spiramycin in Streptomyces ambofaciens.(Microbiology (Mosc.)) [2007] |
|
77
|
Q56176_STRVN (Q56176) |
|
|
4e-37 |
160 |
38% |
|
- Product
- ORF5; putative
- Gene
-
- Organism
- Streptomyces violaceoruber
|
1uniprot[Pubmed] 7476861 [Medline] 96027933 Identification of Streptomyces violaceoruber Tu22 genes involved in the biosynthesis of granaticin.(Mol. Gen. Genet.) [1995] |
|
78
|
O33935_SACER (O33935) |
|
|
6e-37 |
159 |
31% |
|
- Product
- Desosaminyltransferase
- Gene
- eryCIII
- Organism
- Saccharopolyspora erythraea
Streptomyces erythraeus
|
1uniprot[Pubmed] 9353926 [Medline] 98015410 Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production.(Microbiology) |
|
79
|
Q9RPA7_STRFR (Q9RPA7) |
|
|
6e-37 |
159 |
34% |
|
- Product
- Glycosyl transferase
- Gene
- urdGT2
- Organism
- Streptomyces fradiae
Streptomyces roseoflavus
|
1uniprot[Pubmed] 10658661 [Medline] 20121748 Two new tailoring enzymes, a glycosyltransferase and an oxygenase, involved in biosynthesis of the angucycline antibiotic urdamycin A in Streptomyces fradiae Tu2717.(Microbiology) [2000] | 2uniprot[Pubmed] 17640665 Structure and action of the C-C bond-forming glycosyltransferase UrdGT2 involved in the biosynthesis of the antibiotic urdamycin.(J. Mol. Biol.) [2007] | [pubmed all]
|
81
|
A4GV85_9ACTO (A4GV85) |
|
|
1e-36 |
159 |
33% |
|
- Product
- Glycosyltransferase
- Gene
- holC
- Organism
- Streptomyces rufochromogenes
|
1uniprot[Pubmed] 17497146 A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007] |
|
82
|
B3TMP5_9ACTO (B3TMP5) |
|
|
1e-36 |
159 |
35% |
|
- Product
- Glycosyltransferase
- Gene
- KijC1
- Organism
- Actinomadura kijaniata
|
1uniprot[Pubmed] 17985890 Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007] |
|
84
|
Q9ZGH7_9ACTO (Q9ZGH7) |
|
|
2e-36 |
158 |
33% |
|
- Product
- Glycosyl transferase
- Gene
- desVII
- Organism
- Streptomyces venezuelae
|
1uniprot[Pubmed] 9770448 [Medline] 98445333 A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity.(Proc. Natl. Acad. Sci. U.S.A.) [1998] |
|
86
|
A4GV88_9ACTO (A4GV88) |
|
|
2e-36 |
157 |
35% |
|
- Product
- Glycosyltransferase
- Gene
- holL
- Organism
- Streptomyces sp. Tu1156
|
1uniprot[Pubmed] 17497146 A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007] |
|
89
|
C4NYL1_9ACTO (C4NYL1) |
|
|
4e-36 |
157 |
37% |
|
- Product
- SaqGT4
- Gene
- saqGT4
- Organism
- Micromonospora sp. Tu 6368
|
1uniprot[Pubmed] 17497146 A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007] | 2uniprot[Pubmed] 19384899 Cloning and sequencing of the biosynthetic gene cluster for saquayamycin z and galtamycin B and the elucidation of the assembly of their saccharide chains.(Chembiochem) [2009] | [pubmed all]
|
90
|
D9UBQ7_STRPR (D9UBQ7) |
|
|
5e-36 |
156 |
33% |
|
- Product
- Putative glycosyltransferase
- Gene
- cpp27
- Organism
- Streptomyces pristinaespiralis
|
1uniprot[Pubmed] 21342465 Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011] |
|
93
|
Q8ZMN4_SALTY (Q8ZMN4) |
|
|
8e-36 |
155 |
31% |
|
- Product
- Putative glycosyl transferase
- Gene
- iroB
STM2773
- Organism
- Salmonella typhimurium
|
1uniprot[Pubmed] 11677609 [Medline] 21534948 Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.(Nature) [2001] |
|
94
|
Q5PEW2_SALPA (Q5PEW2) |
|
|
8e-36 |
155 |
31% |
|
- Product
- Putative glycosyltransferase
- Gene
- iroB
SPA2629
- Organism
- Salmonella paratyphi A
|
1uniprot[Pubmed] 15531882 Comparison of genome degradation in Paratyphi A and Typhi, human-restricted serovars of Salmonella enterica that cause typhoid.(Nat. Genet.) [2004] |
|
97
|
D0ZTZ2_SALT1 (D0ZTZ2) |
|
|
8e-36 |
155 |
31% |
|
- Product
- Putative glycosyl transferase
- Gene
- iroB
STM14_3344
- Organism
- Salmonella typhimurium (strain 14028s / SGSC 2262)
|
1uniprot[Pubmed] 19897643 Short-term signatures of evolutionary change in the Salmonella enterica serovar typhimurium 14028 genome.(J. Bacteriol.) [2010] |
|
98
|
C9XDV1_SALTD (C9XDV1) |
|
|
8e-36 |
155 |
31% |
|
- Product
- Putative glycosyltransferase
- Gene
- STMMW_27401
- Organism
- Salmonella typhimurium (strain D23580)
|
1uniprot[Pubmed] 19901036 Epidemic multiple drug resistant Salmonella Typhimurium causing invasive disease in sub-Saharan Africa have a distinct genotype.(Genome Res.) [2009] |
|
99
|
C0PW42_SALPC (C0PW42) |
|
|
8e-36 |
155 |
31% |
|
- Product
- Putative glycosyltransferase
- Gene
- iroB
SPC_2813
- Organism
- Salmonella paratyphi C (strain RKS4594)
|
1uniprot[Pubmed] 19229335 Salmonella paratyphi C: genetic divergence from Salmonella choleraesuis and pathogenic convergence with Salmonella typhi.(PLoS ONE) [2009] |
|