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遺伝子 : Mercuric reductase (MERA)

遺伝子情報

ID NRULE_0008
遺伝子ID MERA
作成日 2012/07/02
タンパク質名
Protein name
Full
Mercuric reductase
EC
EC 1.16.1.1
Synonym
Full
Hg(II) reductase
遺伝子名 merA
遺伝子条件 TIGRFAMs; TIGR02053; hit=1
参照
Gene Ontology
GO
GO:0005737, C:cytoplasm, IEA:InterPro
GO:0050660, F:flavin adenine dinucleotide binding, IEA:InterPro
GO:0016152, F:mercury (II) reductase activity, IEA:EC
GO:0045340, F:mercury ion binding, IEA:InterPro
GO:0050661, F:NADP binding, IEA:InterPro
GO:0016668, F:oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor, IEA:InterPro
GO:0045454, P:cell redox homeostasis, IEA:InterPro
GO:0050787, P:detoxification of mercury ion, IEA:InterPro
GO:0030001, P:metal ion transport, IEA:InterPro
Family and domain databases
InterPro
IPR017969, Heavy-metal-associated_CS
IPR006121, HeavyMe-assoc_HMA
IPR021179, Mercury_reductase_MerA
IPR004099, Pyr_nucl-diS_OxRdtase_dimer
IPR023753, Pyr_nucl-diS_OxRdtase_FAD/NAD
IPR012999, Pyr_OxRdtase_I_AS
IPR001327, Pyr_OxRdtase_NAD-bd_dom
Pfam
PF00403, HMA, 1
PF00070, Pyr_redox, 1
PF07992, Pyr_redox_2, 1
PF02852, Pyr_redox_dim, 1
PIRSF
PIRSF000350, Mercury_reductase_MerA, 1
TIGRFAMs
TIGR02053, MerA, 1
PROSITE
PS01047, HMA_1, 2
PS50846, HMA_2, 2
PS00076, PYRIDINE_REDOX_1, 1
配列の特徴
P16171 Bacillus cereus.
METAL264Mercury.
METAL605Mercury.
METAL628Mercury.
METAL629Mercury (Potential).
DISULFID207 - 212Redox-active (By similarity).
注釈
Function
Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0)
Catalytic activity
Hg + NADP(+) + H(+) = Hg(2+) + NADPH
Cofactor
Binds 1 FAD per subunit
Subunit structure
Homodimer
Sequence similarities
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Contains 2 HMA domains
参考文献
P16171 Bacillus cereus.
7988676
In vivo and in vitro effects of mutagenesis of active site tyrosine residues of mercuric reductase. (FEBS Lett. 1994)
8338845
Role of tyrosine residues in Hg(II) detoxification by mercuric reductase from Bacillus sp. strain RC607. (Biochemistry. 1993)



関与する機能

機能名
Mercury resistance

該当CDS

データダウンロード
学名 NBRC番号 CDS タンパク質名
Acholeplasma laidlawii14400ACL_0780mercuric reductase
Acidimicrobium ferrooxidans103882Afer_2009pyridine nucleotide-disulphide oxidoreductase dimerization region
Acidiphilium multivorum100883ACMV_26480mercuric reductase
ACMV_P1_00190mercuric reductase
Acidithiobacillus ferrooxidansLferr_2107mercuric reductase
Aerococcus viridans12219HMPREF0061_1869mercury(II) reductase
Aeropyrum pernix100138APE_1458mercuric reductase (MerA)
Anoxybacillus flavithermus15317Aflv_1424Mercuric reductase
Ardenticatena maritimaARMA_1653mercuric reductase
Brevundimonas diminuta12697BDIM_13960mercuric reductase
Cellulomonas fimi15513Celf_3663mercuric reductase
Cellulomonas flavigena3775Cfla_3663mercuric reductase
Chryseobacterium gleum15054HMPREF0204_12980mercury(II) reductase
Chthonomonas calidiroseaCCALI_01249mercuric reductase
Congregibacter litoralis104960KT71_16211mercuric reductase
Corynebacterium ammoniagenes12612HMPREF0281_01658mercury(II) reductase
Corynebacterium glutamicum12153KIQ_09200hypothetical protein
Corynebacterium striatum15291HMPREF0308_0197mercury(II) reductase
Cupriavidus metallidurans102507Rmet_6174mercuric reductase involved in Hg(II) resistance,MerA from Tn4380
Rmet_6183MerA from Tn4378, mercuric reductase involved in Hg(II) resistance
Deferribacter desulfuricans101012DEFDS_0908mercuric reductase
Enterobacter cloacae subsp. cloacae13535ECL_03824putative mercuric reductase
ECL_A045Mercuric reductase
ECL_A232Mercuric reductase
Gordonia aichiensis108223GOACH_33_00270mercuric reductase
GOACH_45_00050mercuric reductase
Gordonia alkanivorans16433GOALK_060_00910mercuric reductase
Gordonia bronchialis16047Gbro_2649mercuric reductase
Gordonia otitidis100426GOOTI_191_00080mercuric reductase
Gordonia rubripertincta101908GORBP_035_00100mercuric reductase
Gordonia sihwensis108236GSI01S_42_00020mercuric reductase
Gordonia sputi100414GOSPT_024_00050mercuric reductase
Gordonia terrae100016GOTRE_001_00830mercuric reductase
Hyphomonas neptunium14232HNE_1691mercuric reductase
Ignavibacterium album101810IALB_1950Mercuric reductase
Kineosphaera limosa100340KILIM_005_00670mercuric reductase
Kyrpidia tusciae15312Btus_2787mercuric reductase
Kytococcus sedentarius15357Ksed_25620mercuric reductase
Limnochorda pilosa110152LIP_3367dihydrolipoamide dehydrogenase/mercuric reductase
Meiothermus silvanus106475Mesil_1148mercuric reductase
Methylacidiphilum infernorumMinf_0451Mercuric ion reductase, contains HMA domain
Micrococcus luteus3333Mlut_06150mercuric reductase
Nitrosomonas europaea14298NE0839merA; mercuric reductase
Nitrososphaera viennensisNVIE_012710mercuric reductase
Oceanithermus profundus100410Ocepr_0477mercuric reductase
Ochrobactrum anthropi15819Oant_3160mercuric reductase
Pseudomonas stutzeri14165PSTAB_1235putative mercuric reductase
Rubrobacter xylanophilus100952Rxyl_1767Mercuric reductase MerA
Saccharomonospora azurea14651SacazDRAFT_00543mercuric reductase
Saccharomonospora cyanea14841SaccyDRAFT_2526mercuric reductase
Saccharomonospora glauca14831SacglDRAFT_02358mercuric reductase
Sphingobium sp.103272SLG_p_00120mercuric reductase
Sporichthya polymorpha12702Spopo_30_01360Mercury(II) reductase
Spopo_30_14320Mercury(II) reductase
Stackebrandtia nassauensis102104Snas_5372mercuric reductase
Staphylococcus epidermidis12993SE_0085dihydrolipoamide dehydrogenase
Streptococcus mitis106071SM12261_0954mercuric reductase
Sulfolobus tokodaii100140STK_10750mercuric reductase
Thermomicrobium roseumtrd_A0380mercuric reductase
Thermus thermophilus101084TTHA1153mercuric reductase
Thermus thermophilus101085TT_C0789mercuric reductase
Turicella otitidis106139HMPREF9719_01326mercuric reductase