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遺伝子 : Redox-sensitive transcriptional activator SoxR (SOXR)

遺伝子情報

ID NRULE_0329
遺伝子ID SOXR
作成日 2014/10/09
タンパク質名
Protein name
Full
Redox-sensitive transcriptional activator SoxR
遺伝子名 soxR
遺伝子条件 TIGRFAMs; TIGR01950; hit=1
参照
Gene Ontology
GO
GO:0051537, F:2 iron, 2 sulfur cluster binding, IDA:EcoCyc
GO:0003677, F:DNA binding, IEA:UniProtKB-KW
GO:0046872, F:metal ion binding, IEA:UniProtKB-KW
GO:0006355, P:regulation of transcription, DNA-templated, IEA:UniProtKB-KW
GO:0006979, P:response to oxidative stress, IMP:EcoCyc
GO:0006351, P:transcription, DNA-templated, IEA:UniProtKB-KW
Phylogenomic databases
eggNOG
COG0789, -
HOGENOM
HOG000266085, -
KO
K13639, -
Family and domain databases
InterPro
IPR009061, DNA-bd_dom_put
IPR000551, MerR-type_HTH_dom
IPR010211, Redox-sen_tscrpt-act_SoxR
IPR015358, Tscrpt_reg_MerR_DNA-bd
Pfam
PF00376, MerR, 1
PF09278, MerR-DNA-bind, 1
PRINTS
PR00040, HTHMERR
SMART
SM00422, HTH_MERR, 1
TIGRFAMs
TIGR01950, SoxR, 1
PROSITE
PS00552, HTH_MERR_1, 1
PS50937, HTH_MERR_2, 1
配列の特徴
P0ACS2 Escherichia coli (strain K12).
METAL119Iron-sulfur (2Fe-2S).
METAL122Iron-sulfur (2Fe-2S).
METAL124Iron-sulfur (2Fe-2S).
METAL130Iron-sulfur (2Fe-2S).
注釈
Function
Activates the transcription of the soxS gene which itself controls the superoxide response regulon. SoxR contains a 2Fe-2S iron-sulfur cluster that may act as a redox sensor system that recognizes superoxide
Subunit structure
Homodimer
Domain
Contains 1 HTH merR-type DNA-binding domain
参考文献
P0ACS2 Escherichia coli (strain K12).
1653416
Molecular characterization of the soxRS genes of Escherichia coli: two genes control a superoxide stress regulon. (Nucleic Acids Res. 1991)
8306957
An iron-sulfur center essential for transcriptional activation by the redox-sensing SoxR protein. (EMBO J. 1994)
7673113
Binuclear [2Fe-2S] clusters in the Escherichia coli SoxR protein and role of the metal centers in transcription. (J Biol Chem. 1995)
10207625
Transcriptional regulation via redox-sensitive iron-sulphur centres in an oxidative stress response. (Biochem Soc Symp. 1999)



関与する機能

機能名
Metal-binding protein

該当CDS

データダウンロード
学名 NBRC番号 CDS タンパク質名
Acetobacter pasteurianus101655APT_2813MerR family transcriptional regulator
Acinetobacter sp.100985ACT4_006_00970putative MerR family transcriptional regulator
Actinoalloteichus cyanogriseus14455G443_05_02880MerR family transcriptional regulator
G443_07_01710MerR family transcriptional regulator
Actinoalloteichus spitiensis102582ACTIDRAF_03505hypothetical protein
ACTIDRAF_18125hypothetical protein
Actinomadura atramentaria14695G339_08235hypothetical protein
Actinoplanes missouriensis102363AMIS_80050putative MerR-family transcriptional regulator
Actinopolyspora iraqiensis103187ACTIR_272_00050MerR family transcriptional regulator
Actinosynnema mirum14064Amir_5717transcriptional regulator, MerR family
Alteromonas macleodii102226MASE_13445MerR family transcriptional regulator
Amycolatopsis azurea14573C791_2049Redox-sensitive transcriptional activator SoxR
C791_2488Redox-sensitive transcriptional activator SoxR
Amycolatopsis mediterranei13415RAM_11515MerR family transcriptional regulator
RAM_15305MerR family transcriptional regulator
Austwickia chelonae105200AUCHE_22_00130putative MerR family transcriptional regulator
Beutenbergia cavernae16432Bcav_0738transcriptional regulator, MerR family
Brevundimonas diminuta12697BDIM_26910redox-sensitive transcriptional activator SoxR
Chromobacterium violaceum12614CV_2793transcriptional activator
Conexibacter woesei100937Cwoe_5668transcriptional regulator, MerR family
Cupriavidus metallidurans102507Rmet_4538transcriptional activator for superoxide response; Fe-S center for redox-sensing (MerR family)
Deinococcus proteolyticus101906Deipr_1050transcriptional regulator, MerR family
Enterobacter aerogenes13534EAE_08560redox-sensitivie transcriptional activator SoxR
Enterobacter cloacae subsp. cloacae13535ECL_00321hypothetical protein
Enterobacter hormaechei105718HMPREF9086_2146redox-sensitive transcriptional activator SoxR
Escherichia coli3972EcolC_3964transcriptional regulator, MerR family
Escherichia coli13500WFL_21535redox-sensitivie transcriptional activator SoxR
Escherichia coli12713Y75_3994DNA-binding transcriptional dual regulator, Fe-S center for redox-sensing
Escherichia fergusonii102419EFER_4164DNA-binding transcriptional dual regulator, Fe-S center for redox-sensing
Escherichia hermannii105704EH105704_02_00080redox-sensitive transcriptional activator SoxR
Geodermatophilus obscurus13315Gobs_0531transcriptional regulator, MerR family
Gluconacetobacter hansenii14816GXY_05993MerR family transcriptional regulator
Gordonia aichiensis108223GOACH_34_00070putative MerR family transcriptional regulator
Gordonia alkanivorans16433GOALK_038_00430putative MerR family transcriptional regulator
Gordonia amarae15530GOAMR_26_00640putative MerR family transcriptional regulator
Gordonia amicalis100051GOAMI_26_00830putative MerR family transcriptional regulator
Gordonia araii100433GOARA_038_00050putative MerR family transcriptional regulator
Gordonia bronchialis16047Gbro_1480redox-sensitive transcriptional activator SoxR
Gbro_2806redox-sensitive transcriptional activator SoxR
Gordonia effusa100432GOEFS_021_00440putative MerR family transcriptional regulator
Gordonia namibiensis108229GONAM_23_00180putative MerR family transcriptional regulator
Gordonia otitidis100426GOOTI_268_00070putative MerR family transcriptional regulator
Gordonia polyisoprenivorans16320GOPIP_032_00320putative MerR family transcriptional regulator
Gordonia rubripertincta101908GORBP_108_00660putative MerR family transcriptional regulator
Gordonia sihwensis108236GSI01S_14_01440putative MerR family transcriptional regulator
Gordonia soli108243GS4_17_00340putative MerR family transcriptional regulator
Gordonia sputi100414GOSPT_089_00010putative MerR family transcriptional regulator
Gordonia terrae100016GOTRE_039_00100putative MerR family transcriptional regulator
Halomonas elongata15536HELO_1767redox-sensitive transcriptional activator SoxR
Hylemonella gracilis14920HGR_11755MerR family transcriptional regulator
Hyphomonas neptunium14232HNE_3426redox-sensitive transcriptional activator SoxR
Intrasporangium calvum12989Intca_0540transcriptional regulator, MerR family
Kineococcus radiotolerans101839Krad_1915putative transcriptional regulator, MerR family
Kitasatospora setae14216KSE_20120putative MerR family transcriptional regulator
KSE_73380putative MerR family transcriptional regulator
Klebsiella pneumoniae14438KPR_0446
Klebsiella pneumoniae subsp. rhinoscleromatis105682HMPREF0484_5554redox-sensitive transcriptional activator SoxR
Kribbella flavida14399Kfla_1066transcriptional regulator, MerR family
Kfla_1985transcriptional regulator, MerR family
Kfla_3638transcriptional regulator, MerR family
Kytococcus sedentarius15357Ksed_01270redox-sensitive transcriptional activator SoxR
Ksed_01780transcriptional regulator, MerR family
Labrenzia aggregata16684SIAM614_09498redox-sensitive transcriptional activator SoxR
Microlunatus phosphovorus101784MLP_31530MerR family transcriptional regulator
Micromonospora aurantiaca16155Micau_6159redox-sensitive transcriptional activator SoxR
Nitriliruptor alkaliphilusNitalDRAFT_4852MerR family transcriptional regulator, redox-sensitive transcriptional activator SoxR
Nocardiopsis dassonvillei14626Ndas_1966transcriptional regulator, MerR family
Ochrobactrum anthropi15819Oant_2950putative transcriptional regulator, MerR family
Ochrobactrum intermedium15820OINT_2000242redox-sensitive transcriptional activator SoxR
Phaeobacter gallaeciensis16654PGA1_c03310redox-sensitive transcriptional activator
Proteus mirabilis105697HMPREF0693_2852redox-sensitive transcriptional activator SoxR
Providencia alcalifaciens105687PROVALCAL_01294redox-sensitive transcriptional activator SoxR
Pseudomonas putida100650PP_2060transcriptional regulator SoxR
Pseudomonas stutzeri14165PSTAB_1687transcriptional regulator SoxR
Renibacterium salmoninarum15589RSal33209_3062redox-sensitive transcriptional activator
Rhizobium etli15573RHE_CH03863redox-sensitive transcriptional regulator-activator protein
RHE_PF00560probable transcriptional regulator protein, MerR family
Rhizobium sp.101917NGR_c16780putative redox-sensitive transcriptional activator SoxR
Rhizobium tropici15247RTCIAT899_CH16685redox-sensitive transcriptional activator SoxR
Rhodococcus erythropolis100887RER_43780putative MerR family transcriptional regulator
RER_55040putative MerR family transcriptional regulator
Rhodococcus opacus108011ROP_03030putative MerR family transcriptional regulator
ROP_57140putative MerR family transcriptional regulator
Roseobacter litoralis15278RLO149_c027610redox-sensitive transcriptional activator SoxR
Saccharomonospora azurea14651SacazDRAFT_03958redox-sensitive transcriptional activator SoxR
Saccharomonospora cyanea14841SaccyDRAFT_1284redox-sensitive transcriptional activator SoxR
Saccharomonospora glauca14831SacglDRAFT_01205redox-sensitive transcriptional activator SoxR
Saccharomonospora viridis12207Svir_10940transcriptional regulator, MerR family
Saccharopolyspora erythraea13426SACE_5764transcriptional regulator, MerR family
Saccharopolyspora spinosa15153SspiN1_010100003223MerR family transcriptional regulator
Saccharothrix espanaensis15066BN6_68570Transcriptional regulator, MerR family
Salinispora arenicola105043Q5S_3193_00020redox-sensitive transcriptional activator SoxR
Salinispora tropica105044Strop_1494redox-sensitive transcriptional activator SoxR
Strop_4471redox-sensitive transcriptional activator SoxR
Sanguibacter keddieii16158Sked_36770redox-sensitive transcriptional activator SoxR
Shimwellia blattae105725EB105725_13_00060redox-sensitive transcriptional activator SoxR
Sphingobium sp.103272SLG_23740putative redox-sensitive transcriptional activator SoxR
Sporichthya polymorpha12702Spopo_31_25200MerR family transcriptional regulator
Stackebrandtia nassauensis102104Snas_0250transcriptional regulator, MerR family
Snas_6360transcriptional regulator, MerR family
Streptomyces avermitilis14893SAV6604putative SoxR-like transcriptional regulator
Streptomyces cattleya14057SCAT_1828Redox-sensitive transcriptional activator soxR
SCAT_4982HTH-type transcriptional activator soxR homolog
Streptomyces clavuligerus13307SCLAV_0925MerR family transcriptional regulator
SCLAV_5436Redox-sensitive transcriptional activator SoxR
Streptomyces ghanaensis15414SSFG_05681MerR-family transcriptional regulator
Streptomyces mobaraensis13819H340_15861MerR family transcriptional regulator
Streptomyces pristinaespiralis13074SSDG_01940MerR-family transcriptional regulator
Streptomyces purpureus13925STRPU_03_03270MerR-family transcriptional regulator
Streptomyces sviceus13980SSEG_06220redox-sensitive transcriptional activator SoxR
Streptomyces venezuelae13096SVEN_1301Redox-sensitive transcriptional activator SoxR
Streptosporangium roseum3776Sros_2489putative transcriptional regulator, MerR family
Sros_3207putative transcriptional regulator, MerR family
Sros_9086putative transcriptional regulator, MerR family
Thermomonospora curvata15933Tcur_2818transcriptional regulator, MerR family
Tsukamurella paurometabola16120Tpau_1099transcriptional regulator, MerR family
Vibrio alginolyticus15630N646_3759SoxR protein
Vibrio ichthyoenteri15847VII00023_11961transcriptional regulator
Vibrio orientalis15638VIOR3934_20280soxR protein
Vibrio tubiashii15644VITU9109_14918soxR protein
Vibrio vulnificus15645B736_12070transcriptional regulator