BLAST table : Medem_00320

DBUniProtKB
accessionDBalignmentEvalueScoreIdent.linkproductgeneorganismec
1
 Q7WT10_9ACTO
(Q7WT10)		 
[query] 1 - 422 (422)
[subject] 1 - 422 (422)
 0.0 854   100% Ketosynthase (KS) alpha subunit med-ORF1 Streptomyces sp. AM-7161
2
 D3U1U7_9BACT
(D3U1U7)		 
[query] 1 - 420 (422)
[subject] 9 - 428 (430)
 0.0 679   79% Keto-acyl synthase alpha uncultured soil bacterium V167
3
 Q9FCM8_STRAT
(Q9FCM8)		 
[query] 1 - 422 (422)
[subject] 1 - 422 (422)
 0.0 679   78% Putative keto synthase Streptomyces antibioticus
4
 Q54281_SACHI
(Q54281)		 
[query] 1 - 416 (422)
[subject] 1 - 416 (422)
 0.0 674   79% Polyketide synthase Saccharopolyspora hirsuta
5
 KAS1_STRVN
(P16540)		 Jump to Grana_00260 
[query] 1 - 421 (422)
[subject] 1 - 421 (421)
 0.0 671   78% Granaticin polyketide putative beta-ketoacyl synthase 1
ORF1		 gra-orf1 Streptomyces violaceoruber 2.3.1.-
6
 Q9X461_STRAE
(Q9X461)		 Jump to Naphcy_00010 
[query] 1 - 421 (422)
[subject] 1 - 421 (421)
 0.0 653   76% Beta-ketoacyl synthase/acyl transferase ncnA Streptomyces arenae
7
 E3T4B0_9ACTO
(E3T4B0)		 
[query] 1 - 421 (422)
[subject] 1 - 421 (421)
 0.0 653   77% Polyketide synthase keto-acyl synthase gra-orf1 Streptomyces vietnamensis
8
 D6EWA7_STRLI
(D6EWA7)		 
[query] 1 - 422 (422)
[subject] 44 - 465 (467)
 0.0 645   75% Actinorhodin polyketide beta-ketoacyl synthase alpha subunit SSPG_02602 Streptomyces lividans TK24
9
 KASA_STRCO
(Q02059)		 Jump to Actino_00180 
[query] 1 - 422 (422)
[subject] 44 - 465 (467)
 0.0 645   75% Actinorhodin polyketide putative beta-ketoacyl synthase 1
actI ORF1		 SCO5087
SCBAC28G1.13		 Streptomyces coelicolor 2.3.1.-
10
 D9W8G1_9ACTO
(D9W8G1)		 
[query] 1 - 418 (422)
[subject] 1 - 418 (422)
 0.0 640   75% Granaticin polyketide putative beta-ketoacyl synthase 1 SSOG_02382 Streptomyces himastatinicus ATCC 53653
11
 Q2J5J3_FRASC
(Q2J5J3)		 
[query] 2 - 417 (422)
[subject] 4 - 419 (424)
 1e-179 632   75% 3-oxoacyl-[acyl-carrier-protein] synthase II Francci3_4101 Frankia sp. (strain CcI3) 2.3.1.41
12
 E3J3P7_FRASU
(E3J3P7)		 
[query] 1 - 418 (422)
[subject] 1 - 418 (422)
 1e-178 628   75% Beta-ketoacyl synthase FraEuI1c_1317 Frankia sp. (strain EuI1c)
13
 D1XRE9_9ACTO
(D1XRE9)		 
[query] 3 - 422 (422)
[subject] 4 - 423 (423)
 1e-176 624   73% Beta-ketoacyl synthase SACTEDRAFT_5259 Streptomyces sp. SA3_actE
14
 Q54173_STRFR
(Q54173)		 Jump to Urd_00120 
[query] 2 - 418 (422)
[subject] 6 - 422 (426)
 1e-176 622   73% Putative ketoacyl synthase UrdA Streptomyces fradiae
Streptomyces roseoflavus
15
 Q84CI2_9ACTO
(Q84CI2)		 
[query] 3 - 422 (422)
[subject] 4 - 423 (423)
 1e-175 620   72% Putative ketoacyl synthase pd2A Streptomyces sp. WP 4669
16
 Q9F6E0_9ACTO
(Q9F6E0)		 Jump to R1128_00020 
[query] 6 - 421 (422)
[subject] 1 - 416 (417)
 1e-175 620   72% Beta-ketoacylsynthase I zhuB Streptomyces sp. R1128
17
 Q93LY4_9ACTO
(Q93LY4)		 
[query] 1 - 422 (422)
[subject] 1 - 422 (422)
 1e-175 620   73% Ketosynthase PgaA pgaA Streptomyces sp. PGA64
18
 E2D2I8_9BACT
(E2D2I8)		 
[query] 1 - 416 (422)
[subject] 5 - 419 (422)
 1e-175 619   74% Ketosynthase uncultured soil bacterium
19
 Q48375_KIBAR
(Q48375)		 
[query] 3 - 421 (422)
[subject] 4 - 422 (423)
 1e-173 612   72% ArdIorf1 ardIorf1 Kibdelosporangium aridum
20
 D3CXT9_9ACTO
(D3CXT9)		 
[query] 1 - 422 (422)
[subject] 1 - 422 (422)
 1e-172 610   71% Beta-ketoacyl synthase FrEUN1fDRAFT_2359 Frankia sp. EUN1f
21
 D2AY44_STRRD
(D2AY44)		 
[query] 3 - 416 (422)
[subject] 5 - 418 (422)
 1e-172 607   71% 3-oxoacyl-(Acyl-carrier-protein) synthase II Sros_4150 Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
22
 Q5U8L3_9ACTO
(Q5U8L3)		 
[query] 5 - 419 (422)
[subject] 1 - 415 (419)
 1e-171 607   72% Type II PKS ketoacyl synthase aspA Streptomyces spiramyceticus
23
 B6SEF1_9ACTO
(B6SEF1)		 Jump to Alnu_00060 
[query] 1 - 418 (422)
[subject] 1 - 418 (421)
 1e-171 607   72% AlnL ketoacyl synthase alpha alnL Streptomyces sp. CM020
24
 Q2HR20_9ACTO
(Q2HR20)		 Jump to Sch475_00380 
[query] 6 - 420 (422)
[subject] 1 - 415 (420)
 1e-171 606   72% Putative ketoacyl synthase schP8 Streptomyces sp. SCC 2136
25
 Q84CJ7_9ACTO
(Q84CJ7)		 
[query] 3 - 422 (422)
[subject] 5 - 424 (424)
 1e-170 603   71% Putative ketoacyl synthase kinA Streptomyces murayamaensis
26
 Q6VMI7_STRAM
(Q6VMI7)		 
[query] 3 - 420 (422)
[subject] 4 - 421 (423)
 1e-170 603   71% Putative ketoacyl synthase alpA Streptomyces ambofaciens
27
 Q1RQS0_STRAM
(Q1RQS0)		 
[query] 3 - 420 (422)
[subject] 4 - 421 (423)
 1e-170 603   71% Putative ketoacyl synthase alpA
SAMT0165
SAMT0166		 Streptomyces ambofaciens ATCC 23877
28
 D5MRH6_9ACTO
(D5MRH6)		 
[query] 3 - 422 (422)
[subject] 4 - 423 (423)
 1e-170 603   71% Putative ketosynthase hrbC Streptomyces sp. 2238-SVT4
29
 Q9AMJ3_STRAT
(Q9AMJ3)		 
[query] 1 - 422 (422)
[subject] 1 - 422 (422)
 1e-169 601   71% Putative ketosynthase SimA1 simA1 Streptomyces antibioticus
30
 O32451_9ACTO
(O32451)		 
[query] 3 - 415 (422)
[subject] 10 - 422 (425)
 1e-169 600   71% ORF 1
PdmA		 pdmA Actinomadura hibisca
31
 F6K0W5_9BACT
(F6K0W5)		 
[query] 3 - 417 (422)
[subject] 4 - 418 (423)
 1e-169 599   73% Ketoacyl synthase uncultured bacterium BAC AB649/1850
32
 Q70J88_STRGR
(Q70J88)		 Jump to Chro_00100 
[query] 1 - 422 (422)
[subject] 1 - 422 (422)
 1e-169 598   71% Ketosynthase cmmP Streptomyces griseus subsp. griseus
33
 C7PWQ5_CATAD
(C7PWQ5)		 
[query] 1 - 421 (422)
[subject] 1 - 421 (421)
 1e-168 597   70% Beta-ketoacyl synthase Caci_6485 Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
34
 Q0JWA1_STRAM
(Q0JWA1)		 
[query] 6 - 418 (422)
[subject] 1 - 413 (417)
 1e-168 597   71% Putative ketoacyl synthase DSMT0185 Streptomyces ambofaciens
35
 A1C179_9ACTO
(A1C179)		 Jump to Aran_00110 
[query] 1 - 422 (422)
[subject] 1 - 423 (423)
 1e-168 597   72% Ketoacyl synthase Streptomyces echinatus
36
 C4NYJ9_9ACTO
(C4NYJ9)		 
[query] 1 - 417 (422)
[subject] 1 - 417 (422)
 1e-168 595   70% SaqA saqA Micromonospora sp. Tu 6368
37
 B5HT08_9ACTO
(B5HT08)		 
[query] 3 - 422 (422)
[subject] 4 - 423 (423)
 1e-167 593   71% 3-oxoacyl-[acyl-carrier-protein] synthase 2 SSEG_09024 Streptomyces sviceus ATCC 29083
38
 D1H0A1_9ACTO
(D1H0A1)		 
[query] 1 - 422 (422)
[subject] 1 - 422 (422)
 1e-167 592   69% Putative ketoacyl synthase (KSa) chryA Streptomyces albaduncus
39
 D7RFJ5_AMYOR
(D7RFJ5)		 
[query] 14 - 421 (422)
[subject] 15 - 422 (422)
 1e-167 592   72% Putative ketosynthase alpha subunit bexA Amycolatopsis orientalis subsp. vinearia
40
 D7BZQ9_STRBB
(D7BZQ9)		 
[query] 5 - 416 (422)
[subject] 1 - 418 (426)
 1e-166 589   69% Beta-ketoacyl synthase SBI_06844 Streptomyces bingchenggensis (strain BCW-1)
41
 Q2PA07_9ACTO
(Q2PA07)		 Jump to Stref_00080 
[query] 1 - 418 (422)
[subject] 1 - 418 (422)
 1e-166 588   69% Ketoacyl synthase stfP Streptomyces steffisburgensis
42
 C7N0D1_SACVD
(C7N0D1)		 
[query] 5 - 417 (422)
[subject] 4 - 417 (426)
 1e-166 588   69% 3-oxoacyl-(Acyl-carrier-protein) synthase Svir_33690 Saccharomonospora viridis (strain ATCC 15386 / DSM 43017 / JCM 3036 / NBRC 12207 / P101)
43
 A7DWI9_STRTE
(A7DWI9)		 
[query] 2 - 414 (422)
[subject] 3 - 415 (429)
 1e-166 588   69% Putative polyketide beta-ketoacyl synthase alpha llpF Streptomyces tendae 2.3.1.-
44
 F4FBT7_VERMA
(F4FBT7)		 
[query] 3 - 414 (422)
[subject] 4 - 415 (420)
 1e-165 587   70% 3-oxoacyl-(Acyl-carrier-protein) synthase 2 VAB18032_18175 Verrucosispora maris (strain AB-18-032)
45
 Q9ZGD7_STRCY
(Q9ZGD7)		 Jump to Lando_00030 
[query] 1 - 422 (422)
[subject] 1 - 424 (424)
 1e-165 585   70% B-ketoacyl-ACP synthase homolog lanA Streptomyces cyanogenus
46
 Q54495_STRNO
(Q54495)		 Jump to Nogl_00370 
[query] 1 - 417 (422)
[subject] 5 - 422 (430)
 1e-164 583   69% Snoa1 snoa1 Streptomyces nogalater
47
 D9UBR8_STRPR
(D9UBR8)		 
[query] 3 - 420 (422)
[subject] 5 - 422 (424)
 1e-164 583   67% Putative ketoacylsynthase, chain length factor alpha-subunit cpp16 Streptomyces pristinaespiralis 2.3.1.179
48
 B5HIV0_STRPR
(B5HIV0)		 
[query] 3 - 420 (422)
[subject] 5 - 422 (424)
 1e-164 583   67% Beta-ketoacylsynthase I SSDG_05087 Streptomyces pristinaespiralis ATCC 25486
49
 D2XDX9_9PSEU
(D2XDX9)		 
[query] 1 - 417 (422)
[subject] 1 - 418 (422)
 1e-164 582   68% AzicA azicA Kibdelosporangium sp. MJ126-NF4
50
 Q9XE00_9ACTO
(Q9XE00)		 
[query] 1 - 417 (422)
[subject] 1 - 418 (423)
 1e-163 579   69% Polyketide synthase Actinomadura verrucosospora
51
 C4PAV1_9ACTO
(C4PAV1)		 
[query] 11 - 406 (422)
[subject] 1 - 396 (396)
 1e-162 577   73% Putative ketoacyl synthase Streptomyces vietnamensis
52
 D9W5B0_9ACTO
(D9W5B0)		 
[query] 1 - 417 (422)
[subject] 1 - 417 (423)
 1e-162 577   66% 3-oxoacyl-[acyl-carrier-protein] synthase 2 SSNG_07340 Streptomyces sp. C
53
 Q56163_9ACTO
(Q56163)		 Jump to Jado_00080 
[query] 3 - 422 (422)
[subject] 4 - 422 (422)
 1e-162 575   71% Jadomycin polyketide ketosynthase jadA Streptomyces venezuelae
54
 D9UKN5_9ACTO
(D9UKN5)		 
[query] 1 - 416 (422)
[subject] 1 - 416 (425)
 1e-162 575   69% 3-oxoacyl-[acyl-carrier-protein] synthase 2 SSLG_05751 Streptomyces sp. SPB78
55
 Q9FD19_STRCU
(Q9FD19)		 
[query] 3 - 420 (422)
[subject] 6 - 423 (428)
 1e-161 572   69% Ketosynthase alpha subunit rubA Streptomyces collinus
56
 D1H0K0_9ACTO
(D1H0K0)		 
[query] 3 - 422 (422)
[subject] 4 - 423 (423)
 1e-160 570   71% Putative ketoacyl synthase ravA Streptomyces sp. C23201NS3
57
 O68918_9ACTO
(O68918)		 Jump to Fren_00120 
[query] 1 - 416 (422)
[subject] 1 - 416 (425)
 1e-160 570   69% Ketoacyl synthase frnL Streptomyces roseofulvus
58
 Q9LCH8_9ACTO
(Q9LCH8)		 
[query] 12 - 402 (422)
[subject] 3 - 393 (393)
 1e-160 569   72% Ketosynthase ks Streptomyces albus
59
 Q54994_9ACTO
(Q54994)		 
[query] 1 - 416 (422)
[subject] 1 - 416 (425)
 1e-160 568   69% Putative uncharacterized protein Streptomyces roseofulvus
60
 Q93LZ8_STRAU
(Q93LZ8)		 
[query] 1 - 417 (422)
[subject] 1 - 417 (423)
 1e-159 566   64% B-ketoacyl-ACP synthase-like protein aur2A Streptomyces aureofaciens
61
 Q53671_STRAA
(Q53671)		 Jump to Mith_00140 
[query] 1 - 417 (422)
[subject] 1 - 416 (422)
 1e-158 563   65% Ketoacyl synthase mtmP Streptomyces argillaceus
62
 D1XH98_9ACTO
(D1XH98)		 
[query] 1 - 416 (422)
[subject] 1 - 416 (421)
 1e-158 563   66% Beta-ketoacyl synthase SACTEDRAFT_2149 Streptomyces sp. SA3_actE
63
 C7QAF2_CATAD
(C7QAF2)		 
[query] 3 - 416 (422)
[subject] 4 - 417 (419)
 1e-158 562   72% Beta-ketoacyl synthase Caci_3546 Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
64
 KAS1_STRCM
(P41175)		 
[query] 3 - 414 (422)
[subject] 4 - 412 (420)
 1e-157 560   69% Putative polyketide beta-ketoacyl synthase 1
ORF1		 Streptomyces cinnamonensis 2.3.1.-
65
 D9W582_9ACTO
(D9W582)		 
[query] 1 - 418 (422)
[subject] 1 - 418 (422)
 1e-157 559   67% 3-oxoacyl-[acyl-carrier-protein] synthase 2 SSNG_07312 Streptomyces sp. C
66
 D9UBT2_STRPR
(D9UBT2)		 
[query] 3 - 421 (422)
[subject] 2 - 422 (422)
 1e-156 557   67% Putative ketoacylsynthase, chain length factor alpha-subunit cpp3 Streptomyces pristinaespiralis 2.3.1.179
67
 B5HIW3_STRPR
(B5HIW3)		 
[query] 3 - 421 (422)
[subject] 2 - 422 (422)
 1e-156 557   67% Ketoacyl synthase SSDG_05100 Streptomyces pristinaespiralis ATCC 25486
68
 E8W952_STRFA
(E8W952)		 
[query] 1 - 418 (422)
[subject] 1 - 419 (423)
 1e-156 556   65% Beta-ketoacyl synthase Sfla_5318 Streptomyces flavogriseus (strain ATCC 33331 / DSM 40990 / IAF-45CD)
69
 Q9FAR5_STRAU
(Q9FAR5)		 
[query] 3 - 418 (422)
[subject] 9 - 423 (427)
 1e-156 555   66% Beta-ketoacyl synthase tcsD Streptomyces aureofaciens
70
 Q56HA2_STRAU
(Q56HA2)		 
[query] 1 - 422 (422)
[subject] 1 - 422 (422)
 1e-155 554   65% Aur1D aur1D Streptomyces aureofaciens
71
 Q54217_STRGR
(Q54217)		 Jump to Griseu_00010 
[query] 1 - 422 (422)
[subject] 1 - 422 (422)
 1e-155 553   67% Ketosynthase Streptomyces griseus
72
 D2SYZ9_MICEC
(D2SYZ9)		 
[query] 2 - 418 (422)
[subject] 3 - 419 (423)
 1e-155 553   64% Ketosynthase Micromonospora echinospora subsp. challisensis
73
 E2EKJ9_9ACTO
(E2EKJ9)		 
[query] 1 - 421 (422)
[subject] 1 - 421 (421)
 1e-155 553   64% Ketosynthase sanF Streptomyces sp. SANK 61196
74
 KAS1_STRGA
(P16538)		 
[query] 3 - 419 (422)
[subject] 7 - 423 (426)
 1e-155 552   65% Tetracenomycin C polyketide putative beta-ketoacyl synthase 1 tcmK Streptomyces glaucescens 2.3.1.-
75
 Q8KSW4_9ACTO
(Q8KSW4)		 Jump to Griseo_00280 
[query] 1 - 417 (422)
[subject] 1 - 418 (426)
 1e-155 552   67% Putative ketosynthase alpha GrhA grhA Streptomyces sp. JP95
76
 D1A6R5_THECD
(D1A6R5)		 
[query] 1 - 416 (422)
[subject] 1 - 416 (422)
 1e-154 549   61% Beta-ketoacyl synthase Tcur_2773 Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
77
 Q93HA2_STRAW
(Q93HA2)		 
[query] 12 - 414 (422)
[subject] 1 - 403 (410)
 1e-153 547   66% 3-oxoacyl-(Acyl carrier protein) synthase I
Putative 3-oxoacyl-ACP synthase I		 pks9-4
SAV2376
SAV_2376		 Streptomyces avermitilis
78
 Q47QL3_THEFY
(Q47QL3)		 
[query] 1 - 414 (422)
[subject] 1 - 412 (420)
 1e-153 545   67% Actinorhodin polyketide beta-ketoacyl synthase alpha subunit / 3-oxoacyl-ACP synthase I Tfu_1218 Thermobifida fusca (strain YX)
79
 Q54814_STRPE
(Q54814)		 Jump to Adria_00270 
[query] 1 - 418 (422)
[subject] 1 - 418 (419)
 1e-152 543   65% Daunorubicin-doxorubicin polyketide synthase dpsA Streptomyces peucetius
80
 D6MSY1_9ACTO
(D6MSY1)		 
[query] 3 - 418 (422)
[subject] 5 - 419 (424)
 1e-152 543   63% SsfA ssfA Streptomyces sp. SF2575
81
 C0JWB4_9ACTO
(C0JWB4)		 Jump to Polk_00190 
[query] 1 - 420 (422)
[subject] 1 - 420 (422)
 1e-152 543   66% PokP1 pokP1 Streptomyces diastatochromogenes
82
 Q9KHK6_9ACTO
(Q9KHK6)		 Jump to Enter_00090 
[query] 1 - 416 (422)
[subject] 1 - 417 (423)
 1e-152 541   64% Putative keto synthase alpha EncA encA Streptomyces maritimus
83
 D8I4M1_AMYMU
(D8I4M1)		 
[query] 1 - 416 (422)
[subject] 1 - 416 (419)
 1e-152 541   64% 3-oxoacyl-[acyl-carrier-protein] synthase II fabF
AMED_5435		 Amycolatopsis mediterranei (strain U-32)
84
 Q4R0M2_STRCX
(Q4R0M2)		 Jump to Chart_00100 
[query] 1 - 421 (422)
[subject] 1 - 421 (422)
 1e-151 538   66% ChaA protein chaA Streptomyces chartreusis
85
 E5RLL7_9ACTO
(E5RLL7)		 
[query] 2 - 421 (422)
[subject] 3 - 422 (423)
 1e-150 537   64% Putative ketoacyl synthase pnxA Streptomyces sp. TA-0256
86
 Q55223_STRSQ
(Q55223)		 Jump to Dauno_00160 
[query] 1 - 418 (422)
[subject] 1 - 417 (418)
 1e-149 533   64% Polyketide synthase dauA Streptomyces sp
87
 B5G886_9ACTO
(B5G886)		 
[query] 3 - 417 (422)
[subject] 5 - 424 (424)
 1e-149 531   63% Tetracenomycin C polyketide beta-ketoacyl synthase 1 SSBG_00494 Streptomyces sp. SPB74
88
 Q6ZZW2_STRAT
(Q6ZZW2)		 Jump to Ovied_00110 
[query] 3 - 363 (422)
[subject] 4 - 364 (374)
 1e-148 531   72% Keto-acyl synthase alpha ovmP Streptomyces antibioticus
89
 B1GSN1_9ACTO
(B1GSN1)		 Jump to Bena_00090 
[query] 3 - 417 (422)
[subject] 5 - 419 (423)
 1e-148 530   64% BenA protein benA Streptomyces sp. A2991200 2.3.1.-
90
 D6K4R1_9ACTO
(D6K4R1)		 
[query] 1 - 419 (422)
[subject] 1 - 419 (422)
 1e-148 528   62% Polyketide beta-ketoacyl synthase 1 SSTG_02042 Streptomyces sp. e14
91
 Q9L551_9ACTO
(Q9L551)		 Jump to Acla_00070 
[query] 3 - 418 (422)
[subject] 4 - 419 (423)
 1e-148 528   63% AknB aknB Streptomyces galilaeus
92
 Q9LCH7_9ACTO
(Q9LCH7)		 
[query] 10 - 402 (422)
[subject] 1 - 394 (394)
 1e-147 525   67% Ketosynthase ks Streptomyces steffisburgensis
93
 Q8VWB3_9ACTO
(Q8VWB3)		 
[query] 3 - 418 (422)
[subject] 4 - 419 (423)
 1e-147 525   63% AknB aknB Streptomyces galilaeus
94
 E3IZH4_FRASU
(E3IZH4)		 
[query] 3 - 421 (422)
[subject] 4 - 434 (434)
 1e-147 525   63% Beta-ketoacyl synthase FraEuI1c_4753 Frankia sp. (strain EuI1c)
95
 Q67G30_9ACTO
(Q67G30)		 Jump to Heda_00280 
[query] 3 - 417 (422)
[subject] 7 - 418 (422)
 1e-146 523   63% Putative keto synthase alpha Streptomyces griseoruber
96
 B0LJ14_9ACTO
(B0LJ14)		 
[query] 4 - 416 (422)
[subject] 3 - 415 (421)
 1e-146 522   62% Lct31 lct31 Streptomyces rishiriensis
97
 Q83X35_STRRO
(Q83X35)		 
[query] 3 - 414 (422)
[subject] 2 - 412 (421)
 1e-146 522   64% Beta-ketoacyl synthase alpha-subunit rocA Streptomyces rochei
Streptomyces parvullus
98
 Q2MGD1_STRGR
(Q2MGD1)		 Jump to Fred_00080 
[query] 1 - 421 (422)
[subject] 1 - 421 (421)
 1e-145 521   62% 3-ketoacyl-ACP synthase Streptomyces griseus
99
 Q2PZR9_9ACTO
(Q2PZR9)		 Jump to Cosmo_00070 
[query] 1 - 422 (422)
[subject] 1 - 422 (422)
 1e-145 521   65% CosB cosB Streptomyces olindensis
100
 KAS1_STRHA
(Q05356)		 
[query] 1 - 418 (422)
[subject] 1 - 418 (422)
 1e-145 520   63% Putative polyketide beta-ketoacyl synthase 1
Polyketide condensing enzyme		 sch1 Streptomyces halstedii 2.3.1.-
accessionDBalignmentEvalueScoreIdent.linkinformationpubmed
1
 Q7WT10_9ACTO
(Q7WT10)		 
[query] 1 - 422 (422)
[subject] 1 - 422 (422)
 0.0 854   100%
Product
Ketosynthase (KS) alpha subunit
Gene
med-ORF1
Organism
Streptomyces sp. AM-7161
1uniprot
Cloning, sequencing and heterologous expression of the medermycin biosynthetic gene cluster of Streptomyces sp. AM-7161: towards comparative analysis of the benzoisochromanequione gene clusters.(Microbiology (Mosc.)) [2003]
3
 Q9FCM8_STRAT
(Q9FCM8)		 
[query] 1 - 422 (422)
[subject] 1 - 422 (422)
 0.0 679   78%
Product
Putative keto synthase
Gene
 
Organism
Streptomyces antibioticus
1uniprot[Pubmed] 11700358 [Medline] 21557167
A polyketide biosynthetic gene cluster from Streptomyces antibioticus includes a LysR-type transcriptional regulator.(Microbiology) [2001]
4
 Q54281_SACHI
(Q54281)		 
[query] 1 - 416 (422)
[subject] 1 - 416 (422)
 0.0 674   79%
Product
Polyketide synthase
Gene
 
Organism
Saccharopolyspora hirsuta
1uniprot[Pubmed] 8341260 [Medline] 93341453
Saccharopolyspora hirsuta 367 encodes clustered genes similar to ketoacyl synthase, ketoacyl reductase, acyl carrier protein, and biotin carboxyl carrier protein.(Mol. Gen. Genet.) [1993]
5
 KAS1_STRVN
(P16540)		 Jump to Grana_00260 
[query] 1 - 421 (422)
[subject] 1 - 421 (421)
 0.0 671   78%
Product
Granaticin polyketide putative beta-ketoacyl synthase 1
ORF1
Gene
gra-orf1
Organism
Streptomyces violaceoruber
1uniprot[Pubmed] 2583128 [Medline] 90060034
Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber Tu22.(EMBO J.) [1989]
2uniprot[Pubmed] 7476861 [Medline] 96027933
Identification of Streptomyces violaceoruber Tu22 genes involved in the biosynthesis of granaticin.(Mol. Gen. Genet.) [1995]
3uniprot[Pubmed] 9831526 [Medline] 99051446
The granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tu22: sequence analysis and expression in a heterologous host.(Chem. Biol.) [1998]
[pubmed all]
6
 Q9X461_STRAE
(Q9X461)		 Jump to Naphcy_00010 
[query] 1 - 421 (422)
[subject] 1 - 421 (421)
 0.0 653   76%
Product
Beta-ketoacyl synthase/acyl transferase
Gene
ncnA
Organism
Streptomyces arenae
1uniprot[Pubmed] 10206788 [Medline] 99217421
Isolation and characterization of the naphthocyclinone gene cluster from Streptomyces arenae DSM 40737 and heterologous expression of the polyketide synthase genes.(Gene) [1999]
9
 KASA_STRCO
(Q02059)		 Jump to Actino_00180 
[query] 1 - 422 (422)
[subject] 44 - 465 (467)
 0.0 645   75%
Product
Actinorhodin polyketide putative beta-ketoacyl synthase 1
actI ORF1
Gene
SCO5087
SCBAC28G1.13
Organism
Streptomyces coelicolor
1uniprot[Pubmed] 12000953 [Medline] 21996410
Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).(Nature) [2002]
2uniprot[Pubmed] 1527048 [Medline] 92406871
Nucleotide sequence and deduced functions of a set of cotranscribed genes of Streptomyces coelicolor A3(2) including the polyketide synthase for the antibiotic actinorhodin.(J. Biol. Chem.) [1992]
[pubmed all]
11
 Q2J5J3_FRASC
(Q2J5J3)		 
[query] 2 - 417 (422)
[subject] 4 - 419 (424)
 1e-179 632   75%
Product
3-oxoacyl-[acyl-carrier-protein] synthase II
Gene
Francci3_4101
Organism
Frankia sp. (strain CcI3)
1uniprot[Pubmed] 17151343
Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007]
14
 Q54173_STRFR
(Q54173)		 Jump to Urd_00120 
[query] 2 - 418 (422)
[subject] 6 - 422 (426)
 1e-176 622   73%
Product
Putative ketoacyl synthase
Gene
UrdA
Organism
Streptomyces fradiae
Streptomyces roseoflavus
1uniprot[Pubmed] 7592377 [Medline] 96042088
Cloning and characterization of a polyketide synthase from Streptomyces fradiae Tue2717 encoding the genes for biosynthesis of the angucycline antibiotic urdamycin A and a gene probably involved in its oxygenation.(J. Bacteriol.) [1995]
16
 Q9F6E0_9ACTO
(Q9F6E0)		 Jump to R1128_00020 
[query] 6 - 421 (422)
[subject] 1 - 416 (417)
 1e-175 620   72%
Product
Beta-ketoacylsynthase I
Gene
zhuB
Organism
Streptomyces sp. R1128
1uniprot[Pubmed] 10931852 [Medline] 20517899
Cloning, nucleotide sequence, and heterologous expression of the biosynthetic gene cluster for R1128, a non-steroidal estrogen receptor antagonist. Insights into an unusual priming mechanism.(J. Biol. Chem.) [2000]
17
 Q93LY4_9ACTO
(Q93LY4)		 
[query] 1 - 422 (422)
[subject] 1 - 422 (422)
 1e-175 620   73%
Product
Ketosynthase PgaA
Gene
pgaA
Organism
Streptomyces sp. PGA64
1uniprot[Pubmed] 12654660 [Medline] 22540650
Engineering anthracycline biosynthesis toward angucyclines.(Antimicrob. Agents Chemother.) [2003]
2uniprot[Pubmed] 15515887
Partial activation of a silent angucycline-type gene cluster from a rubromycin beta producing Streptomyces sp. PGA64.(J. Antibiot.) [2004]
[pubmed all]
18
 E2D2I8_9BACT
(E2D2I8)		 
[query] 1 - 416 (422)
[subject] 5 - 419 (422)
 1e-175 619   74%
Product
Ketosynthase
Gene
 
Organism
uncultured soil bacterium
1uniprot[Pubmed] 20577994
Cloning large natural product gene clusters from the environment: piecing environmental DNA gene clusters back together with TAR.(Biopolymers) [2010]
19
 Q48375_KIBAR
(Q48375)		 
[query] 3 - 421 (422)
[subject] 4 - 422 (423)
 1e-173 612   72%
Product
ArdIorf1
Gene
ardIorf1
Organism
Kibdelosporangium aridum
1uniprot[Pubmed] 7987007 [Medline] 95078455
Cloning and nucleotide sequence of a region of the Kibdelosporangium aridum genome homologous to polyketide biosynthetic genes.(DNA Seq.) [1994]
21
 D2AY44_STRRD
(D2AY44)		 
[query] 3 - 416 (422)
[subject] 5 - 418 (422)
 1e-172 607   71%
Product
3-oxoacyl-(Acyl-carrier-protein) synthase II
Gene
Sros_4150
Organism
Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
1uniprot
Complete genome sequence of Streptosporangium roseum type strain (NI 9100T).(Stand. Genomic Sci.) [2010]
23
 B6SEF1_9ACTO
(B6SEF1)		 Jump to Alnu_00060 
[query] 1 - 418 (422)
[subject] 1 - 418 (421)
 1e-171 607   72%
Product
AlnL ketoacyl synthase alpha
Gene
alnL
Organism
Streptomyces sp. CM020
1uniprot[Pubmed] 18940666
Characterization of the alnumycin gene cluster reveals unusual gene products for pyran ring formation and dioxan biosynthesis.(Chem. Biol.) [2008]
24
 Q2HR20_9ACTO
(Q2HR20)		 Jump to Sch475_00380 
[query] 6 - 420 (422)
[subject] 1 - 415 (420)
 1e-171 606   72%
Product
Putative ketoacyl synthase
Gene
schP8
Organism
Streptomyces sp. SCC 2136
1uniprot
Angucyclines Sch 47554 and Sch 47555 from Streptomyces sp. SCC-2136: Cloning, Sequencing, and Characterization.(Mol. Cells) [2006]
2uniprot
Molecular cloning and characterization of biosynthetic genes cluster of Sch 47554 from Streptomyces sp. SCC 2136. [2004]
26
 Q6VMI7_STRAM
(Q6VMI7)		 
[query] 3 - 420 (422)
[subject] 4 - 421 (423)
 1e-170 603   71%
Product
Putative ketoacyl synthase
Gene
alpA
Organism
Streptomyces ambofaciens
1uniprot[Pubmed] 14742212
Functional angucycline-like antibiotic gene cluster in the terminal inverted repeats of the Streptomyces ambofaciens linear chromosome.(Antimicrob. Agents Chemother.) [2004]
27
 Q1RQS0_STRAM
(Q1RQS0)		 
[query] 3 - 420 (422)
[subject] 4 - 421 (423)
 1e-170 603   71%
Product
Putative ketoacyl synthase
Gene
alpA
SAMT0165
SAMT0166
Organism
Streptomyces ambofaciens ATCC 23877
1uniprot[Pubmed] 16952952
Intraspecific variability of the terminal inverted repeats of the linear chromosome of Streptomyces ambofaciens.(J. Bacteriol.) [2006]
2uniprot[Pubmed] 16956972
Evolution of the terminal regions of the Streptomyces linear chromosome.(Mol. Biol. Evol.) [2006]
3uniprot
Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877.(Microbiology (Mosc.)) [2006]
[pubmed all]
28
 D5MRH6_9ACTO
(D5MRH6)		 
[query] 3 - 422 (422)
[subject] 4 - 423 (423)
 1e-170 603   71%
Product
Putative ketosynthase
Gene
hrbC
Organism
Streptomyces sp. 2238-SVT4
1uniprot[Pubmed] 20453135
Cloning and characterization of a gene cluster for hatomarubigin biosynthesis in Streptomyces sp. strain 2238-SVT4.(Appl. Environ. Microbiol.) [2010]
29
 Q9AMJ3_STRAT
(Q9AMJ3)		 
[query] 1 - 422 (422)
[subject] 1 - 422 (422)
 1e-169 601   71%
Product
Putative ketosynthase SimA1
Gene
simA1
Organism
Streptomyces antibioticus
1uniprot[Pubmed] 11959542 [Medline] 21955989
Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibiotic.(Antimicrob. Agents Chemother.) [2002]
30
 O32451_9ACTO
(O32451)		 
[query] 3 - 415 (422)
[subject] 10 - 422 (425)
 1e-169 600   71%
Product
ORF 1
PdmA
Gene
pdmA
Organism
Actinomadura hibisca
1uniprot[Pubmed] 9339544 [Medline] 97480928
Cloning and nucleotide sequence of the putative polyketide synthase genes for pradimicin biosynthesis from Actinomadura hibisca.(Biosci. Biotechnol. Biochem.) [1997]
33
 C7PWQ5_CATAD
(C7PWQ5)		 
[query] 1 - 421 (422)
[subject] 1 - 421 (421)
 1e-168 597   70%
Product
Beta-ketoacyl synthase
Gene
Caci_6485
Organism
Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
1uniprot
Complete genome sequence of Catenulispora acidiphila type strain (ID 139908).(Stand. Genomic Sci.) [2009]
34
 Q0JWA1_STRAM
(Q0JWA1)		 
[query] 6 - 418 (422)
[subject] 1 - 413 (417)
 1e-168 597   71%
Product
Putative ketoacyl synthase
Gene
DSMT0185
Organism
Streptomyces ambofaciens
1uniprot[Pubmed] 16952952
Intraspecific variability of the terminal inverted repeats of the linear chromosome of Streptomyces ambofaciens.(J. Bacteriol.) [2006]
36
 C4NYJ9_9ACTO
(C4NYJ9)		 
[query] 1 - 417 (422)
[subject] 1 - 417 (422)
 1e-168 595   70%
Product
SaqA
Gene
saqA
Organism
Micromonospora sp. Tu 6368
1uniprot[Pubmed] 17497146
A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]
2uniprot[Pubmed] 19384899
Cloning and sequencing of the biosynthetic gene cluster for saquayamycin z and galtamycin B and the elucidation of the assembly of their saccharide chains.(Chembiochem) [2009]
[pubmed all]
39
 D7RFJ5_AMYOR
(D7RFJ5)		 
[query] 14 - 421 (422)
[subject] 15 - 422 (422)
 1e-167 592   72%
Product
Putative ketosynthase alpha subunit
Gene
bexA
Organism
Amycolatopsis orientalis subsp. vinearia
1uniprot[Pubmed] 20443562
A biosynthetic pathway for BE-7585A, a 2-thiosugar-containing angucycline-type natural product.(J. Am. Chem. Soc.) [2010]
40
 D7BZQ9_STRBB
(D7BZQ9)		 
[query] 5 - 416 (422)
[subject] 1 - 418 (426)
 1e-166 589   69%
Product
Beta-ketoacyl synthase
Gene
SBI_06844
Organism
Streptomyces bingchenggensis (strain BCW-1)
1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]
41
 Q2PA07_9ACTO
(Q2PA07)		 Jump to Stref_00080 
[query] 1 - 418 (422)
[subject] 1 - 418 (422)
 1e-166 588   69%
Product
Ketoacyl synthase
Gene
stfP
Organism
Streptomyces steffisburgensis
1uniprot[Pubmed] 16751529
Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin.(Appl. Environ. Microbiol.) [2006]
42
 C7N0D1_SACVD
(C7N0D1)		 
[query] 5 - 417 (422)
[subject] 4 - 417 (426)
 1e-166 588   69%
Product
3-oxoacyl-(Acyl-carrier-protein) synthase
Gene
Svir_33690
Organism
Saccharomonospora viridis (strain ATCC 15386 / DSM 43017 / JCM 3036 / NBRC 12207 / P101)
1uniprot
Complete genome sequence of Saccharomonospora viridis type strain (P101T).(Stand. Genomic Sci.) [2009]
43
 A7DWI9_STRTE
(A7DWI9)		 
[query] 2 - 414 (422)
[subject] 3 - 415 (429)
 1e-166 588   69%
Product
Putative polyketide beta-ketoacyl synthase alpha
Gene
llpF
Organism
Streptomyces tendae
1uniprot
Isolation of the lysolipin gene cluster of Streptomyces tendae Tu 4042.(Gene) [2010]
44
 F4FBT7_VERMA
(F4FBT7)		 
[query] 3 - 414 (422)
[subject] 4 - 415 (420)
 1e-165 587   70%
Product
3-oxoacyl-(Acyl-carrier-protein) synthase 2
Gene
VAB18032_18175
Organism
Verrucosispora maris (strain AB-18-032)
1uniprot[Pubmed] 21551311
Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.(J. Bacteriol.) [2011]
45
 Q9ZGD7_STRCY
(Q9ZGD7)		 Jump to Lando_00030 
[query] 1 - 422 (422)
[subject] 1 - 424 (424)
 1e-165 585   70%
Product
B-ketoacyl-ACP synthase homolog
Gene
lanA
Organism
Streptomyces cyanogenus
1uniprot[Pubmed] 9933932 [Medline] 99132695
Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin biosynthesis.(FEMS Microbiol. Lett.) [1999]
46
 Q54495_STRNO
(Q54495)		 Jump to Nogl_00370 
[query] 1 - 417 (422)
[subject] 5 - 422 (430)
 1e-164 583   69%
Product
Snoa1
Gene
snoa1
Organism
Streptomyces nogalater
1uniprot[Pubmed] 8668120 [Medline] 96242142
A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.(Mol. Gen. Genet.) [1996]
2uniprot[Pubmed] 9349712 [Medline] 98007868
Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.(Mol. Gen. Genet.) [1997]
3uniprot[Pubmed] 8760909 [Medline] 96349102
Production of hybrid anthracycline antibiotics by heterologous expression of Streptomyces nogalater nogalamycin biosynthesis genes.(Microbiology) [1996]
[pubmed all]
47
 D9UBR8_STRPR
(D9UBR8)		 
[query] 3 - 420 (422)
[subject] 5 - 422 (424)
 1e-164 583   67%
Product
Putative ketoacylsynthase, chain length factor alpha-subunit
Gene
cpp16
Organism
Streptomyces pristinaespiralis
1uniprot[Pubmed] 21342465
Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011]
49
 D2XDX9_9PSEU
(D2XDX9)		 
[query] 1 - 417 (422)
[subject] 1 - 418 (422)
 1e-164 582   68%
Product
AzicA
Gene
azicA
Organism
Kibdelosporangium sp. MJ126-NF4
1uniprot[Pubmed] 19928906
Biosynthetic studies of aziridine formation in azicemicins.(J. Am. Chem. Soc.) [2009]
50
 Q9XE00_9ACTO
(Q9XE00)		 
[query] 1 - 417 (422)
[subject] 1 - 418 (423)
 1e-163 579   69%
Product
Polyketide synthase
Gene
 
Organism
Actinomadura verrucosospora
1uniprot[Pubmed] 10347064 [Medline] 99278093
Development of a self-cloning system for Actinomadura verrucosospora and identification of polyketide synthase genes essential for production of the angucyclic antibiotic pradimicin.(Appl. Environ. Microbiol.) [1999]
53
 Q56163_9ACTO
(Q56163)		 Jump to Jado_00080 
[query] 3 - 422 (422)
[subject] 4 - 422 (422)
 1e-162 575   71%
Product
Jadomycin polyketide ketosynthase
Gene
jadA
Organism
Streptomyces venezuelae
1uniprot[Pubmed] 7881555 [Medline] 95187308
Cloning and characterization of polyketide synthase genes for jadomycin B biosynthesis in Streptomyces venezuelae ISP5230.(Microbiology) [1994]
2uniprot
Functional characterization of the jadI gene as a cyclase forming angucyclinones.(J. Am. Chem. Soc.) [1999]
57
 O68918_9ACTO
(O68918)		 Jump to Fren_00120 
[query] 1 - 416 (422)
[subject] 1 - 416 (425)
 1e-160 570   69%
Product
Ketoacyl synthase
Gene
frnL
Organism
Streptomyces roseofulvus
1uniprot[Pubmed] 8181754 [Medline] 94237486
Cloning, sequencing and deduced functions of a cluster of Streptomyces genes probably encoding biosynthesis of the polyketide antibiotic frenolicin.(Gene) [1994]
59
 Q54994_9ACTO
(Q54994)		 
[query] 1 - 416 (422)
[subject] 1 - 416 (425)
 1e-160 568   69%
Product
Putative uncharacterized protein
Gene
 
Organism
Streptomyces roseofulvus
1uniprot[Pubmed] 8181754 [Medline] 94237486
Cloning, sequencing and deduced functions of a cluster of Streptomyces genes probably encoding biosynthesis of the polyketide antibiotic frenolicin.(Gene) [1994]
60
 Q93LZ8_STRAU
(Q93LZ8)		 
[query] 1 - 417 (422)
[subject] 1 - 417 (423)
 1e-159 566   64%
Product
B-ketoacyl-ACP synthase-like protein
Gene
aur2A
Organism
Streptomyces aureofaciens
1uniprot[Pubmed] 15497441
Cloning and characterization of a new polyketide synthase gene cluster in Streptomyces aureofaciens CCM 3239.(DNA Seq.) [2004]
61
 Q53671_STRAA
(Q53671)		 Jump to Mith_00140 
[query] 1 - 417 (422)
[subject] 1 - 416 (422)
 1e-158 563   65%
Product
Ketoacyl synthase
Gene
mtmP
Organism
Streptomyces argillaceus
1uniprot[Pubmed] 8654997 [Medline] 96257259
Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144
An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479
Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047
Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478
Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236
Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456
Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776
The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809
Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752
The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297
Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254
Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461
Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994
Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398
Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238
Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589
MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823
Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316
Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873
The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]
[pubmed all]
63
 C7QAF2_CATAD
(C7QAF2)		 
[query] 3 - 416 (422)
[subject] 4 - 417 (419)
 1e-158 562   72%
Product
Beta-ketoacyl synthase
Gene
Caci_3546
Organism
Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
1uniprot
Complete genome sequence of Catenulispora acidiphila type strain (ID 139908).(Stand. Genomic Sci.) [2009]
64
 KAS1_STRCM
(P41175)		 
[query] 3 - 414 (422)
[subject] 4 - 412 (420)
 1e-157 560   69%
Product
Putative polyketide beta-ketoacyl synthase 1
ORF1
Gene
 
Organism
Streptomyces cinnamonensis
1uniprot[Pubmed] 1508151 [Medline] 92374994
Characterisation of actI-homologous DNA encoding polyketide synthase genes from the monensin producer Streptomyces cinnamonensis.(Mol. Gen. Genet.) [1992]
66
 D9UBT2_STRPR
(D9UBT2)		 
[query] 3 - 421 (422)
[subject] 2 - 422 (422)
 1e-156 557   67%
Product
Putative ketoacylsynthase, chain length factor alpha-subunit
Gene
cpp3
Organism
Streptomyces pristinaespiralis
1uniprot[Pubmed] 21342465
Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011]
70
 Q56HA2_STRAU
(Q56HA2)		 
[query] 1 - 422 (422)
[subject] 1 - 422 (422)
 1e-155 554   65%
Product
Aur1D
Gene
aur1D
Organism
Streptomyces aureofaciens
1uniprot[Pubmed] 12384301 [Medline] 22271582
Cloning and characterization of a polyketide synthase gene cluster involved in biosynthesis of a proposed angucycline-like polyketide auricin in Streptomyces aureofaciens CCM 3239.(Gene) [2002]
2uniprot[Pubmed] 16079347
Characterization of a regulatory gene essential for the production of the angucycline-like polyketide antibiotic auricin in Streptomyces aureofaciens CCM 3239.(Microbiology) [2005]
3uniprot[Pubmed] 20466770
The role of the TetR-family transcriptional regulator Aur1R in negative regulation of the auricin gene cluster in Streptomyces aureofaciens CCM 3239.(Microbiology) [2010]
[pubmed all]
71
 Q54217_STRGR
(Q54217)		 Jump to Griseu_00010 
[query] 1 - 422 (422)
[subject] 1 - 422 (422)
 1e-155 553   67%
Product
Ketosynthase
Gene
 
Organism
Streptomyces griseus
1uniprot[Pubmed] 8169211 [Medline] 94222841
Cloning, sequencing, and analysis of the griseusin polyketide synthase gene cluster from Streptomyces griseus.(J. Bacteriol.) [1994]
72
 D2SYZ9_MICEC
(D2SYZ9)		 
[query] 2 - 418 (422)
[subject] 3 - 419 (423)
 1e-155 553   64%
Product
Ketosynthase
Gene
 
Organism
Micromonospora echinospora subsp. challisensis
1uniprot[Pubmed] 19680283
TLN-05220, TLN-05223, new Echinosporamicin-type antibiotics, and proposed revision of the structure of bravomicins(*).(J. Antibiot.) [2009]
73
 E2EKJ9_9ACTO
(E2EKJ9)		 
[query] 1 - 421 (422)
[subject] 1 - 421 (421)
 1e-155 553   64%
Product
Ketosynthase
Gene
sanF
Organism
Streptomyces sp. SANK 61196
1uniprot[Pubmed] 20550125
Cloning, sequencing, heterologous expression, and mechanistic analysis of A-74528 biosynthesis.(J. Am. Chem. Soc.) [2010]
74
 KAS1_STRGA
(P16538)		 
[query] 3 - 419 (422)
[subject] 7 - 423 (426)
 1e-155 552   65%
Product
Tetracenomycin C polyketide putative beta-ketoacyl synthase 1
Gene
tcmK
Organism
Streptomyces glaucescens
1uniprot[Pubmed] 2684656 [Medline] 90060035
Analysis of the nucleotide sequence of the Streptomyces glaucescens tcmI genes provides key information about the enzymology of polyketide antibiotic biosynthesis.(EMBO J.) [1989]
75
 Q8KSW4_9ACTO
(Q8KSW4)		 Jump to Griseo_00280 
[query] 1 - 417 (422)
[subject] 1 - 418 (426)
 1e-155 552   67%
Product
Putative ketosynthase alpha GrhA
Gene
grhA
Organism
Streptomyces sp. JP95
1uniprot[Pubmed] 12323376 [Medline] 22235582
A gene cluster from a marine Streptomyces encoding the biosynthesis of the aromatic spiroketal polyketide griseorhodin A.(Chem. Biol.) [2002]
76
 D1A6R5_THECD
(D1A6R5)		 
[query] 1 - 416 (422)
[subject] 1 - 416 (422)
 1e-154 549   61%
Product
Beta-ketoacyl synthase
Gene
Tcur_2773
Organism
Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
1uniprot
Complete genome sequence of Thermomonospora curvata type strain (B9).(Stand. Genomic Sci.) [2011]
77
 Q93HA2_STRAW
(Q93HA2)		 
[query] 12 - 414 (422)
[subject] 1 - 403 (410)
 1e-153 547   66%
Product
3-oxoacyl-(Acyl carrier protein) synthase I
Putative 3-oxoacyl-ACP synthase I
Gene
pks9-4
SAV2376
SAV_2376
Organism
Streptomyces avermitilis
1uniprot[Pubmed] 11572948 [Medline] 21477403
Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.(Proc. Natl. Acad. Sci. U.S.A.) [2001]
2uniprot[Pubmed] 12692562 [Medline] 22608306
Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis.(Nat. Biotechnol.) [2003]
[pubmed all]
78
 Q47QL3_THEFY
(Q47QL3)		 
[query] 1 - 414 (422)
[subject] 1 - 412 (420)
 1e-153 545   67%
Product
Actinorhodin polyketide beta-ketoacyl synthase alpha subunit / 3-oxoacyl-ACP synthase I
Gene
Tfu_1218
Organism
Thermobifida fusca (strain YX)
1uniprot[Pubmed] 17209016
Genome sequence and analysis of the soil cellulolytic actinomycete Thermobifida fusca YX.(J. Bacteriol.) [2007]
79
 Q54814_STRPE
(Q54814)		 Jump to Adria_00270 
[query] 1 - 418 (422)
[subject] 1 - 418 (419)
 1e-152 543   65%
Product
Daunorubicin-doxorubicin polyketide synthase
Gene
dpsA
Organism
Streptomyces peucetius
1uniprot[Pubmed] 7828855 [Medline] 95129838
Characterization of the Streptomyces peucetius ATCC 29050 genes encoding doxorubicin polyketide synthase.(Gene) [1994]
80
 D6MSY1_9ACTO
(D6MSY1)		 
[query] 3 - 418 (422)
[subject] 5 - 419 (424)
 1e-152 543   63%
Product
SsfA
Gene
ssfA
Organism
Streptomyces sp. SF2575
1uniprot[Pubmed] 19908837
Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.(J. Am. Chem. Soc.) [2009]
81
 C0JWB4_9ACTO
(C0JWB4)		 Jump to Polk_00190 
[query] 1 - 420 (422)
[subject] 1 - 420 (422)
 1e-152 543   66%
Product
PokP1
Gene
pokP1
Organism
Streptomyces diastatochromogenes
1uniprot[Pubmed] 19266534
Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009]
82
 Q9KHK6_9ACTO
(Q9KHK6)		 Jump to Enter_00090 
[query] 1 - 416 (422)
[subject] 1 - 417 (423)
 1e-152 541   64%
Product
Putative keto synthase alpha EncA
Gene
encA
Organism
Streptomyces maritimus
1uniprot
Natural Metabolic Diversity Encoded by the Enterocin Biosynthesis Gene Cluster.(J. Am. Chem. Soc.) [2000]
2uniprot[Pubmed] 11137817 [Medline] 20579517
Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate 'Streptomyces maritimus': evidence for the derailment of an aromatic polyketide synthase.(Chem. Biol.) [2000]
3uniprot[Pubmed] 11948863 [Medline] 21942282
A mechanism of benzoic acid biosynthesis in plants and bacteria that mirrors fatty acid beta-oxidation.(Chembiochem) [2001]
[pubmed all]
83
 D8I4M1_AMYMU
(D8I4M1)		 
[query] 1 - 416 (422)
[subject] 1 - 416 (419)
 1e-152 541   64%
Product
3-oxoacyl-[acyl-carrier-protein] synthase II
Gene
fabF
AMED_5435
Organism
Amycolatopsis mediterranei (strain U-32)
1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]
84
 Q4R0M2_STRCX
(Q4R0M2)		 Jump to Chart_00100 
[query] 1 - 421 (422)
[subject] 1 - 421 (422)
 1e-151 538   66%
Product
ChaA protein
Gene
chaA
Organism
Streptomyces chartreusis
1uniprot[Pubmed] 15911378
Biosynthesis of the antitumor agent chartreusin involves the oxidative rearrangement of an anthracyclic polyketide.(Chem. Biol.) [2005]
86
 Q55223_STRSQ
(Q55223)		 Jump to Dauno_00160 
[query] 1 - 418 (422)
[subject] 1 - 417 (418)
 1e-149 533   64%
Product
Polyketide synthase
Gene
dauA
Organism
Streptomyces sp
1uniprot[Pubmed] 7928998 [Medline] 95014072
Isolation and sequence analysis of polyketide synthase genes from the daunomycin-producing Streptomyces sp. strain C5.(J. Bacteriol.) [1994]
89
 B1GSN1_9ACTO
(B1GSN1)		 Jump to Bena_00090 
[query] 3 - 417 (422)
[subject] 5 - 419 (423)
 1e-148 530   64%
Product
BenA protein
Gene
benA
Organism
Streptomyces sp. A2991200
1uniprot[Pubmed] 17439117
Molecular analysis of the benastatin biosynthetic pathway and genetic engineering of altered fatty acid-polyketide hybrids.(J. Am. Chem. Soc.) [2007]
91
 Q9L551_9ACTO
(Q9L551)		 Jump to Acla_00070 
[query] 3 - 418 (422)
[subject] 4 - 419 (423)
 1e-148 528   63%
Product
AknB
Gene
aknB
Organism
Streptomyces galilaeus
1uniprot[Pubmed] 12137949 [Medline] 22133312
Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster.(Gene) [2002]
93
 Q8VWB3_9ACTO
(Q8VWB3)		 
[query] 3 - 418 (422)
[subject] 4 - 419 (423)
 1e-147 525   63%
Product
AknB
Gene
aknB
Organism
Streptomyces galilaeus
1uniprot[Pubmed] 12399480 [Medline] 22286521
Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus.(J. Bacteriol.) [2002]
95
 Q67G30_9ACTO
(Q67G30)		 Jump to Heda_00280 
[query] 3 - 417 (422)
[subject] 7 - 418 (422)
 1e-146 523   63%
Product
Putative keto synthase alpha
Gene
 
Organism
Streptomyces griseoruber
1uniprot[Pubmed] 15271354
The hedamycin locus implicates a novel aromatic PKS priming mechanism.(Chem. Biol.) [2004]
96
 B0LJ14_9ACTO
(B0LJ14)		 
[query] 4 - 416 (422)
[subject] 3 - 415 (421)
 1e-146 522   62%
Product
Lct31
Gene
lct31
Organism
Streptomyces rishiriensis
1uniprot[Pubmed] 18070976
Biosynthetic investigations of lactonamycin and lactonamycin z: cloning of the biosynthetic gene clusters and discovery of an unusual starter unit.(Antimicrob. Agents Chemother.) [2008]
97
 Q83X35_STRRO
(Q83X35)		 
[query] 3 - 414 (422)
[subject] 2 - 412 (421)
 1e-146 522   64%
Product
Beta-ketoacyl synthase alpha-subunit
Gene
rocA
Organism
Streptomyces rochei
Streptomyces parvullus
1uniprot[Pubmed] 12791134 [Medline] 22676866
The large linear plasmid pSLA2-L of Streptomyces rochei has an unusually condensed gene organization for secondary metabolism.(Mol. Microbiol.) [2003]
2uniprot[Pubmed] 10954087 [Medline] 20408175
Cloning and analysis of the replication origin and the telomeres of the large linear plasmid pSLA2-L in Streptomyces rochei.(Mol. Gen. Genet.) [2000]
3uniprot[Pubmed] 10767533 [Medline] 20231737
Identification of two polyketide synthase gene clusters on the linear plasmid pSLA2-L in Streptomyces rochei.(Gene) [2000]
4uniprot[Pubmed] 9836424 [Medline] 99053144
Physical mapping of the linear plasmid pSLA2-L and localization of the eryAI and actI homologs.(Biosci. Biotechnol. Biochem.) [1998]
[pubmed all]
98
 Q2MGD1_STRGR
(Q2MGD1)		 Jump to Fred_00080 
[query] 1 - 421 (422)
[subject] 1 - 421 (421)
 1e-145 521   62%
Product
3-ketoacyl-ACP synthase
Gene
 
Organism
Streptomyces griseus
1uniprot[Pubmed] 16305230
Cloning, sequencing, analysis, and heterologous expression of the fredericamycin biosynthetic gene cluster from Streptomyces griseus.(J. Am. Chem. Soc.) [2005]
99
 Q2PZR9_9ACTO
(Q2PZR9)		 Jump to Cosmo_00070 
[query] 1 - 422 (422)
[subject] 1 - 422 (422)
 1e-145 521   65%
Product
CosB
Gene
cosB
Organism
Streptomyces olindensis
1uniprot[Pubmed] 16810496
Insights in the glycosylation steps during biosynthesis of the antitumor anthracycline cosmomycin: characterization of two glycosyltransferase genes.(Appl. Microbiol. Biotechnol.) [2006]
100
 KAS1_STRHA
(Q05356)		 
[query] 1 - 418 (422)
[subject] 1 - 418 (422)
 1e-145 520   63%
Product
Putative polyketide beta-ketoacyl synthase 1
Polyketide condensing enzyme
Gene
sch1
Organism
Streptomyces halstedii
1uniprot[Pubmed] 8344517 [Medline] 93345807
Hybridization and DNA sequence analyses suggest an early evolutionary divergence of related biosynthetic gene sets encoding polyketide antibiotics and spore pigments in Streptomyces spp.(Gene) [1993]