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Rule : Trehalose-phosphate synthase (TPS)

Rule Description

ID NRULE_0119
Rule name TPS
Created 2013-01-22
Protein name
Protein name
Full
Trehalose-phosphate synthase
EC
EC 2.4.1.-
Synonym
Full
Trehalose-6-phosphate synthase
Gene name otsA
Rule Trigger TIGRFAMs; TIGR02400; hit=1
OR
BLASTP; O06353; hit=1; score=1000; pid=50
Cross Reference
Gene Ontology
GO
GO:0005618, C:cell wall, IDA:MTBBASE
GO:0005829, C:cytosol, TAS:Reactome
GO:0005886, C:plasma membrane, IDA:MTBBASE
GO:0047260, F:alpha,alpha-trehalose-phosphate synthase (GDP-forming) activity, IDA:MTBBASE
GO:0003825, F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity, IDA:MTBBASE
GO:0030145, F:manganese ion binding, IDA:MTBBASE
GO:0040007, P:growth, IMP:MTBBASE
GO:0051289, P:protein homotetramerization, IPI:MTBBASE
GO:0005992, P:trehalose biosynthetic process, IDA:MTBBASE
Phylogenomic databases
eggNOG
COG0380, -
HOGENOM
HOG000191477, -
KO
K00697, -
ProtClustDB
CLSK872185, -
Enzyme and pathway databases
UniPathway
UPA00299, -
Family and domain databases
InterPro
IPR001830, Glyco_trans_20
Pfam
PF00982, Glyco_transf_20, 1
Feature Not assigned
General annotation
Function
Catalyzes the transfer of glucose from a nucleoside diphosphate-glucose to glucose-6-phosphate to form trehalose-6- phosphate and nucleoside diphosphate. TPS is specific for the glucosyl acceptor but not for the glucosyl donor
Catalytic activity
Nucleoside diphosphate-glucose + D-glucose 6- phosphate = trehalose 6-phosphate + nucleoside diphosphate
Pathway
Glycan biosynthesis; trehalose biosynthesis
Subunit structure
Homotetramer
Sequence similarities
Belongs to the glycosyltransferase 20 family
Reference
O06353 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
12473104
Trehalose-phosphate synthase of Mycobacterium tuberculosis. Cloning, expression and properties of the recombinant enzyme. (Eur J Biochem. 2002)
P31677 Escherichia coli (strain K12).
3131312
Biochemical and genetic characterization of osmoregulatory trehalose synthesis in Escherichia coli. (J Bacteriol. 1988)



Related Function

Function name
Trehalose biosynthesis (from NDP-glucose and glucose-6-phosphate)

CDS

Data Download
Scientific name NBRC No. CDS Product name
Acaricomes phytoseiuli107788C501_00405trehalose-phosphate synthase
Actinoalloteichus cyanogriseus14455G443_01_06900alpha,alpha-trehalose-phosphate synthase (UDP- forming)
Actinoalloteichus spitiensis102582ACTIDRAF_13575trehalose-phosphate synthase
Actinoplanes missouriensis102363AMIS_10890putative trehalose-6-phosphate synthase
Actinopolyspora iraqiensis103187ACTIR_430_00020alpha,alpha-trehalose-phosphate synthase (UDP- forming)
Actinosynnema mirum14064Amir_0371Alpha,alpha-trehalose-phosphate synthase (UDP- forming)
Amycolatopsis azurea14573C791_1271Alpha,alpha-trehalose-phosphate synthase
C791_7147Alpha,alpha-trehalose-phosphate synthase
Amycolatopsis mediterranei13415RAM_44490trehalose-6-phosphate synthase
Archaeoglobus profundus100127Arcpr_1593alpha,alpha-trehalose-phosphate synthase (UDP-forming)
Arthrobacter globiformis12137ARGLB_012_00090alpha,alpha-trehalose-phosphate synthase
Austwickia chelonae105200AUCHE_08_00860alpha,alpha-trehalose-phosphate synthase
Azorhizobium caulinodans14845AZC_0482OtsA trehalose-6-phosphate synthase
Beutenbergia cavernae16432Bcav_0796Alpha,alpha-trehalose-phosphate synthase (UDP-forming)
Brevibacterium linens12170BlinB_010200014950Alpha,alpha-trehalose-phosphate synthase (UDP-forming)
Catenulispora acidiphila102108Caci_2546Alpha,alpha-trehalose-phosphate synthase (UDP- forming)
Caci_2644Alpha,alpha-trehalose-phosphate synthase (UDP- forming)
Caci_3724Alpha,alpha-trehalose-phosphate synthase (UDP- forming)
Caulobacter segnis15250Cseg_1575Alpha,alpha-trehalose-phosphate synthase (UDP-forming)
Cellulomonas fimi15513Celf_0618Alpha,alpha-trehalose-phosphate synthase (UDP-forming)
Cellulomonas flavigena3775Cfla_0676Alpha,alpha-trehalose-phosphate synthase (UDP- forming)
Cellulophaga lytica14961Celly_2540trehalose-phosphatase
Corynebacterium ammoniagenes12612HMPREF0281_01450putative alpha,alpha-trehalose-phosphate synthase (UDP-forming)
Corynebacterium callunae15359H924_11075alpha,alpha-trehalose-phosphate synthase
Corynebacterium efficiens100395CE2508putative trehalose-6-phosphate synthase
Corynebacterium glutamicum12168Cgl2624Trehalose-6-phosphate synthase
Corynebacterium glutamicum12153KIQ_12590alpha,alpha-trehalose-phosphate synthase
Corynebacterium matruchotii15360HMPREF0299_7568putative alpha,alpha-trehalose-phosphate synthase (UDP-forming)
Corynebacterium striatum15291HMPREF0308_2618putative alpha,alpha-trehalose-phosphate synthase (UDP-forming)
Corynebacterium terpenotabidum14764A606_02185alpha,alpha-trehalose-phosphate synthase
Cupriavidus metallidurans102507Rmet_0357trehalose-6-phosphate synthase
Enterobacter aerogenes13534EAE_22940trehalose-6-phosphate synthase
Enterobacter cloacae subsp. cloacae13535ECL_01398trehalose-6-phosphate synthase
Enterobacter hormaechei105718HMPREF9086_2897alpha,alpha-trehalose-phosphate synthase
Escherichia coli3972EcolC_1738alpha,alpha-trehalose-phosphate synthase (UDP-forming)
Escherichia coli13500WFL_10160trehalose-6-phosphate synthase
Escherichia coli12713Y75_1893trehalose-6-phosphate synthase
Escherichia fergusonii102419EFER_1127trehalose-6-phosphate synthase
Escherichia hermannii105704EH105704_01_03970alpha,alpha-trehalose-phosphate synthase
Geodermatophilus obscurus13315Gobs_5012Alpha,alpha-trehalose-phosphate synthase (UDP- forming)
Gordonia aichiensis108223GOACH_04_03210alpha,alpha-trehalose-phosphate synthase
Gordonia alkanivorans16433GOALK_050_00720alpha,alpha-trehalose-phosphate synthase
Gordonia amarae15530GOAMR_26_00160alpha,alpha-trehalose-phosphate synthase
Gordonia amicalis100051GOAMI_14_01950alpha,alpha-trehalose-phosphate synthase
Gordonia araii100433GOARA_082_00320alpha,alpha-trehalose-phosphate synthase
Gordonia bronchialis16047Gbro_0808Alpha,alpha-trehalose-phosphate synthase (UDP- forming)
Gordonia effusa100432GOEFS_035_00070alpha,alpha-trehalose-phosphate synthase
Gordonia hirsuta16056GOHSU_14_00880alpha,alpha-trehalose-phosphate synthase
Gordonia namibiensis108229GONAM_22_00270alpha,alpha-trehalose-phosphate synthase
Gordonia otitidis100426GOOTI_130_00600alpha,alpha-trehalose-phosphate synthase
Gordonia polyisoprenivorans16320GOPIP_087_02380alpha,alpha-trehalose-phosphate synthase
Gordonia rhizosphera16068GORHZ_046_00700alpha,alpha-trehalose-phosphate synthase
Gordonia rubripertincta101908GORBP_100_00140alpha,alpha-trehalose-phosphate synthase
Gordonia sihwensis108236GSI01S_25_00850alpha,alpha-trehalose-phosphate synthase
Gordonia soli108243GS4_32_01300alpha,alpha-trehalose-phosphate synthase
Gordonia sputi100414GOSPT_142_00060alpha,alpha-trehalose-phosphate synthase
Gordonia terrae100016GOTRE_136_00600alpha,alpha-trehalose-phosphate synthase
Intrasporangium calvum12989Intca_2909trehalose 6-phosphate synthase
Jonesia denitrificans15587Jden_2063Alpha,alpha-trehalose-phosphate synthase (UDP- forming)
Kineococcus radiotolerans101839Krad_0920Alpha,alpha-trehalose-phosphate synthase (UDP-forming)
Kineosphaera limosa100340KILIM_027_00020alpha,alpha-trehalose-phosphate synthase
Klebsiella pneumoniae14438KPR_3305
Klebsiella pneumoniae subsp. rhinoscleromatis105682HMPREF0484_2194alpha,alpha-trehalose-phosphate synthase (UDP-forming)
Kocuria rhizophila103217KRH_18540alpha,alpha-trehalose-phosphate synthase
Kribbella flavida14399Kfla_1215Alpha,alpha-trehalose-phosphate synthase (UDP- forming)
Kytococcus sedentarius15357Ksed_03840trehalose 6-phosphate synthase
Microlunatus phosphovorus101784MLP_33530alpha,alpha-trehalose-phosphate synthase
Micromonospora aurantiaca16155Micau_4541Alpha,alpha-trehalose-phosphate synthase (UDP-forming)
Micau_4956Alpha,alpha-trehalose-phosphate synthase (UDP-forming)
Microscilla marina16560M23134_00593trehalose-6-phosphate synthase-phosphatase
Mobilicoccus pelagius104925MOPEL_005_00420alpha,alpha-trehalose-phosphate synthase
Nakamurella multipartita105858Namu_4915trehalose-phosphatase
Ochrobactrum anthropi15819Oant_2713alpha,alpha-trehalose-phosphate synthase (UDP-forming)
Ochrobactrum intermedium15820OINT_1000603alpha,alpha-trehalose-phosphate synthase [UDP-forming]
Propionibacterium acidipropionici12425PACID_18560Alpha,alpha-trehalose-phosphate synthase
Propionibacterium avidum15671HMPREF9153_2002alpha,alpha-trehalose-phosphate synthase
Pseudomonas stutzeri14165PSTAB_3283alpha,alpha-trehalose-phosphate synthase
Rahnella aquatilis105701Rahaq2_4935UDP-forming alpha,alpha-trehalose-phosphate synthase
Renibacterium salmoninarum15589RSal33209_0446trehalose-6-phosphate synthase
Rhizobium etli15573RHE_CH00476trehalose-6-phosphate synthase protein
Rhizobium sp.101917NGR_a02090putative alpha,alpha-trehalose-6-phosphate synthase OtsA
Rhizobium tropici15247RTCIAT899_CH02085alpha,alpha-trehalose-phosphate synthase (UDP-forming)
Rhodobacter sphaeroides12203RSP_0948probable OtsA trehalose-6-phosphate synthase
Rhodococcus erythropolis100887RER_09680alpha,alpha-trehalose-phosphate synthase
RER_12840alpha,alpha-trehalose-phosphate synthase
Rhodococcus opacus108011ROP_02140putative alpha,alpha-trehalose-phosphate synthase
ROP_48060putative alpha,alpha-trehalose-phosphate synthase
Saccharomonospora azurea14651SacazDRAFT_02276Trehalose-6-phosphate synthase
Saccharomonospora cyanea14841SaccyDRAFT_4624Trehalose-6-phosphate synthase
Saccharomonospora glauca14831SacglDRAFT_03893Trehalose-6-phosphate synthase
Saccharomonospora viridis12207Svir_35050trehalose 6-phosphate synthase
Saccharopolyspora erythraea13426SACE_0462trehalose-6-phosphate synthase
Saccharopolyspora spinosa15153SspiN1_010100021438trehalose-phosphate synthase
Saccharothrix espanaensis15066BN6_04110alpha,alpha-trehalose-phosphate synthase
Salinispora arenicola105043Q5S_2331_00060alpha,alpha-trehalose-phosphate synthase (UDP-forming)
Q5S_2542_00040alpha,alpha-trehalose-phosphate synthase (UDP-forming)
Salinispora tropica105044Strop_3271Alpha,alpha-trehalose-phosphate synthase (UDP-forming)
Strop_3543Alpha,alpha-trehalose-phosphate synthase (UDP-forming)
Sanguibacter keddieii16158Sked_31700trehalose 6-phosphate synthase
Shimwellia blattae105725EB105725_04_03540alpha,alpha-trehalose-phosphate synthase
Solitalea canadensis15130Solca_2056UDP-forming alpha,alpha-trehalose-phosphate synthase
Sphingobacterium spiritivorum14948HMPREF0766_13135trehalose-phosphatase
Sphingobium japonicum101211SJA_C1-14720alpha,alpha-trehalose-phosphate synthase (UDP-forming)
Stackebrandtia nassauensis102104Snas_4642Alpha,alpha-trehalose-phosphate synthase (UDP- forming)
Streptosporangium roseum3776Sros_6769Alpha,alpha-trehalose-phosphate synthase (UDP- forming)
Thermobispora bispora14880Tbis_2294Alpha,alpha-trehalose-phosphate synthase (UDP- forming)
Thermomonospora curvata15933Tcur_1967Alpha,alpha-trehalose-phosphate synthase (UDP- forming)
Thermoproteus neutrophilus100436Tneu_0273alpha,alpha-trehalose-phosphate synthase (UDP-forming)
Tsukamurella paurometabola16120Tpau_3642Alpha,alpha-trehalose-phosphate synthase (UDP- forming)
Xylanimonas cellulosilytica107835Xcel_2949trehalose-phosphatase