遺伝子 : Beta-lactamase class A (BLAA)

遺伝子情報

ID	NRULE_0122
遺伝子ID	BLAA
作成日	2013/01/28
タンパク質名	Protein name Full Beta-lactamase class A EC EC 3.5.2.6
遺伝子名	bla
遺伝子条件	PROSITE; PS00146; hit=1
参照	Gene Ontology GO GO:0008800, F:beta-lactamase activity, IEA:EC GO:0030655, P:beta-lactam antibiotic catabolic process, IEA:InterPro GO:0046677, P:response to antibiotic, IEA:UniProtKB-KW Family and domain databases InterPro IPR000871, Beta-lactam_class-A/D IPR023650, Beta-lactam_class-A_AS PRINTS PR00118, BLACTAMASEA PROSITE PS00146, BETA_LACTAMASE_A, 1
配列の特徴	P62593 Escherichia coli. ACT_SITE 68 Acyl-ester intermediate. ACT_SITE 166 Proton acceptor. DISULFID 75 - 121
注釈	Catalytic activity A beta-lactam + H(2)O = a substituted beta- amino acid Sequence similarities Belongs to the class-A beta-lactamase family
参考文献	P62593 Escherichia coli. 358200 Nucleotide sequence of the ampicillin resistance gene of Escherichia coli plasmid pBR322. (Proc Natl Acad Sci U S A. 1978) P00807 Staphylococcus aureus. 3104315 Nucleotide sequence and expression of the beta-lactamase gene from Staphylococcus aureus plasmid pI258 in Escherichia coli, Bacillus subtilis, and Staphylococcus aureus. (J Bacteriol. 1987) Q5YXD6 Nocardia farcinica (strain IFM 10152). 10390216 Biochemical-genetic analysis and distribution of FAR-1, a class A beta-lactamase from Nocardia farcinica. (Antimicrob Agents Chemother. 1999)

関与する機能

機能名
Ampicillin resistance
Beta-lactam antibiotic resistance
Cephalosporin resistance
Penicillin resistance

該当CDS

学名	NBRC番号	CDS	タンパク質名
Acaricomes phytoseiuli	107788	C501_01820	hypothetical protein
Acetobacter pasteurianus	101655	APT_2795	putative beta-lactamase precursor
Acetobacter tropicalis	101654	ATPR_0478	putative beta-lactamase
Acidobacterium capsulatum	15755	ACP_3424	beta-lactamase
Actinoalloteichus cyanogriseus	14455	G443_13_01510	PenP
Actinoalloteichus spitiensis	102582	ACTIDRAF_13195	hypothetical protein
Actinomadura atramentaria	14695	G339_26840	hypothetical protein
Actinoplanes missouriensis	102363	AMIS_31990	putative D-alanyl-D-alanine carboxypeptidase
Actinosynnema mirum	14064	Amir_3962	Beta-lactamase
Amycolatopsis azurea	14573	C791_0605	Beta-lactamase
		C791_2898	Beta-lactamase class A
		C791_5740	Beta-lactamase class A
Amycolatopsis mediterranei	13415	RAM_18065	beta-lactamase class C
		RAM_26100	beta-lactamase class A
Azorhizobium caulinodans	14845	AZC_4278	beta-lactamase
Bacillus amyloliquefaciens	15535	BAMF_1288	beta-lactamase precursor
Bacillus atrophaeus	13721	BATRMS_13_00950	beta-lactamase
Bacillus cereus	15305	BC_2473	Beta-lactamase
Bacillus licheniformis	12200	BL01642	beta-lactamase precursor
Bacillus licheniformis	12195	BLi00280	beta-lactamase PenP
Bacillus mycoides	101228	bmyco0001_22080	Beta-lactamase
		bmyco0001_23170	Beta-lactamase 3
		bmyco0001_7930	Beta-lactamase 3
Bacillus pseudomycoides	101232	bpmyx0001_49550	Beta-lactamase 3
Bacillus psychrosaccharolyticus	101233	WYK_252_00110	beta-lactamase 3
Bacillus subtilis	3134	BSU6633_06094	beta-lactamase precursor
Bacillus subtilis subsp. subtilis	13719	BSU18800	beta-lactamase precursor
Bacillus thuringiensis	101235	bthur0008_23060	Beta-lactamase
		bthur0008_29430	Beta-lactamase 3
Bacillus vallismortis	101236	BvalD_010100015845	beta-lactamase
		BvalD_010100020938	beta-lactamase TEM
Bacteroides vulgatus	14291	BVU_3257	beta-lactamase precursor
Bradyrhizobium diazoefficiens	14792	bll0941	beta-lactamase L2 precursor
Brevibacillus brevis	100599	BBR47_12040	beta-lactamase precursor
Brevibacterium linens	12170	BlinB_010200008960	beta-lactamase
Brevundimonas diminuta	12697	BDIM_00300	beta-lactamase
Brevundimonas subvibrioides	16000	Bresu_1970	beta-lactamase
		Bresu_2808	Beta-lactamase
Candidatus Solibacter usitatus		Acid_2285	Beta-lactamase
Catenulispora acidiphila	102108	Caci_5163	Beta-lactamase
Caulobacter segnis	15250	Cseg_3400	Beta-lactamase
Clostridium kluyveri	12016	CKR_2572	hypothetical protein
Cystobacter fuscus	100088	D187_001958	hypothetical protein
Escherichia fergusonii	102419	EFER_1643	Beta-lactamase TEM precursor (penicillinase)
		EFER_p0036	Beta-lactamase TEM precursor (Penicillinase)
Escherichia hermannii	105704	EH105704_10_00980	putative class A beta-lactamase
Fischerella sp.		PCC9339_RS0111695	class A beta-lactamase
Fluviicola taffensis	106335	Fluta_3361	beta-lactamase
Gluconacetobacter hansenii	14816	GXY_03758	beta-lactamase
Gluconobacter frateurii	101659	GfraN1_010100012751	Beta-lactamase
Gordonia araii	100433	GOARA_045_00350	class A beta-lactamase
Gordonia effusa	100432	GOEFS_086_00450	putative class A beta-lactamase
Halomonas elongata	15536	HELO_1444	beta-lactamase
Kineococcus radiotolerans	101839	Krad_1931	Beta-lactamase
Kitasatospora setae	14216	KSE_57690	putative beta-lactamase
Klebsiella pneumoniae	14438	KPR_2492
Klebsiella pneumoniae subsp. rhinoscleromatis	105682	HMPREF0484_4462	beta-lactamase
Kribbella flavida	14399	Kfla_4213	Beta-lactamase
Labrenzia aggregata	16684	SIAM614_09023	Beta-lactamase class A
Lactobacillus reuteri	15892	LAR_1450	D-alanyl-D-alanine carboxypeptidase
Methylobacterium radiotolerans	15690	Mrad2831_4082	Beta-lactamase
Micromonospora aurantiaca	16155	Micau_2858	Beta-lactamase
Nocardiopsis dassonvillei	14626	Ndas_2388	Beta-lactamase
		Ndas_2389	Beta-lactamase
Paenibacillus alvei	3343	PAV_7c02290	beta-lactamase Bla
Phaeobacter gallaeciensis	16654	PGA1_c09800	beta-lactamase Bla
Phycisphaera mikurensis	102666	PSMK_24770	peptidase S12 family protein
Rhizobium etli	15573	RHE_CH01220	beta-lactamase protein
Rhizobium tropici	15247	RTCIAT899_CH05265	beta-lactamase family protein
Rhodococcus opacus	108011	ROP_02970	class A beta-lactamase
Saccharomonospora azurea	14651	SacazDRAFT_00164	beta-lactamase class A
Saccharomonospora cyanea	14841	SaccyDRAFT_2039	beta-lactamase class A
Saccharomonospora glauca	14831	SacglDRAFT_01897	beta-lactamase class A
Saccharopolyspora erythraea	13426	SACE_1374	beta-lactamase precursor
Saccharopolyspora spinosa	15153	SspiN1_010100034029	beta-lactamase
Saccharothrix espanaensis	15066	BN6_39610	Beta-lactamase
Salinispora arenicola	105043	Q5S_3455_00010	ampicillin resistance protein
		Q5S_937_00010	beta-lactamase
Salinispora tropica	105044	Strop_1457	Beta-lactamase
Solitalea canadensis	15130	Solca_0574	beta-lactamase class A
Sphingobium japonicum	101211	SJA_C1-21720	beta-lactamase class A
		SJA_C1-31380	beta-lactamase class A
Sphingobium sp.	103272	SLG_01940	beta-lactamase class A
Staphylococcus epidermidis	12993	SE_1608	beta-lactamase
Staphylococcus saprophyticus subsp. saprophyticus	102446	SSP2186	similar to beta-lactamase precursor
Streptomyces avermitilis	14893	SAV4452	putative beta-lactamase
Streptomyces cattleya	14057	SCAT_5692	Beta-lactamase
Streptomyces clavuligerus	13307	SCLAV_3128	alkaline D-peptidase
Streptomyces ghanaensis	15414	SSFG_03503	class A beta-lactamase
Streptomyces mobaraensis	13819	H340_20253	beta-lactamase
Streptomyces pristinaespiralis	13074	SSDG_02287	beta-lactamase
		SSDG_05985	beta-lactamase
Streptomyces purpureus	13925	STRPU_17_05490	Putative beta-lactamase
Streptomyces sviceus	13980	SSEG_04136	beta-lactamase
Streptomyces venezuelae	13096	SVEN_0089	Beta-lactamase
Streptosporangium roseum	3776	Sros_5706	Beta-lactamase
		Sros_7334	hypothetical protein
Vibrio alginolyticus	15630	N646_4682	beta-lactamase
Yersinia rohdei	105715	yrohd0001_31630	Beta-lactamase