BLAST table : Aver_00120

DB	UniProtKB

	accession	Evalue	Score	Ident.	link	product	gene	organism	ec
1	Q9S0P5_STRAW (Q9S0P5)	0.0	719	100%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	aveBII SAV946 SAV_946	Streptomyces avermitilis	4.2.1.46 niceE keggE
2	Q9F5R6_STRSD (Q9F5R6)	1e-141	504	76%	UniProt GenBank	dTDP-glucose 4,6-dehydratase		Streptomyces sp. (strain ATCC 17920 / DSM 40477 / NCIB 11028) Streptomyces tenebrarius	4.2.1.46 niceE keggE
3	C7MUW7_SACVD (C7MUW7)	1e-140	504	73%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	Svir_06090	Saccharomonospora viridis (strain ATCC 15386 / DSM 43017 / JCM 3036 / NBRC 12207 / P101)	4.2.1.46 niceE keggE
4	D9V6R3_9ACTO (D9V6R3)	1e-140	504	74%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	SSMG_00677	Streptomyces sp. AA4	4.2.1.46 niceE keggE
5	E0L0G4_STRVO (E0L0G4)	1e-139	499	74%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	StrviDRAFT_8392	Streptomyces violaceusniger Tu 4113	4.2.1.46 niceE keggE
6	C6WJ73_ACTMD (C6WJ73)	1e-138	497	74%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	Amir_6347	Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971)	4.2.1.46 niceE keggE
7	D8I3S0_AMYMU (D8I3S0)	1e-138	494	74%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	rfbB AMED_1007	Amycolatopsis mediterranei (strain U-32)	4.2.1.46 niceE keggE
8	A0ACJ2_STRAM (A0ACJ2)	1e-137	492	73%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	SAMR0486	Streptomyces ambofaciens ATCC 23877	4.2.1.46 niceE keggE
9	A4FNM4_SACEN (A4FNM4)	1e-134	481	70%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	aveBII SACE_6480	Saccharopolyspora erythraea (strain NRRL 23338)	4.2.1.46 niceE keggE
10	Q54116_SACER (Q54116)	1e-134	481	70%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	gdh	Saccharopolyspora erythraea Streptomyces erythraeus	4.2.1.46 niceE keggE
11	Q93EK0_9PSEU (Q93EK0)	1e-134	481	71%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	gdh	Saccharopolyspora spinosa	4.2.1.46 niceE keggE
12	Q83WD7_MICGR (Q83WD7)	1e-131	473	71%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	mydB	Micromonospora griseorubida	4.2.1.46 niceE keggE
13	B3TMR2_9ACTO (B3TMR2)	1e-131	471	69%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	KijD4	Actinomadura kijaniata	4.2.1.46 niceE keggE
14	F4CKA6_9PSEU (F4CKA6)	1e-130	471	72%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	Psed_0177	Pseudonocardia dioxanivorans CB1190	4.2.1.46 niceE keggE
15	A8CAC2_9ACTO (A8CAC2)	1e-128	462	69%	UniProt GenBank	dTDP-glucose 4,6-dehydratase		Streptomyces eurythermus	4.2.1.46 niceE keggE
16	Q5SFD3_STRBI (Q5SFD3)	1e-127	457	69%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	chmAII	Streptomyces bikiniensis	4.2.1.46 niceE keggE
17	B5L6K3_MICCH (B5L6K3)	1e-126	456	69%	UniProt GenBank	dTDP-glucose 4,6-dehydratase		Micromonospora chalcea	4.2.1.46 niceE keggE
18	B0RDV6_CLAMS (B0RDV6)	1e-126	456	70%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	CMS0629	Clavibacter michiganensis subsp. sepedonicus (strain ATCC 33113 / JCM 9667)	4.2.1.46 niceE keggE
19	Q9ZGH3_9ACTO (Q9ZGH3)	1e-126	455	69%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	desIV	Streptomyces venezuelae	4.2.1.46 niceE keggE
20	A5CPQ0_CLAM3 (A5CPQ0)	1e-126	455	69%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	rmlB CMM_1010	Clavibacter michiganensis subsp. michiganensis (strain NCPPB 382)	4.2.1.46 niceE keggE
21	A4AI60_9ACTN (A4AI60)	1e-126	454	69%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	A20C1_06126	marine actinobacterium PHSC20C1	4.2.1.46 niceE keggE
22	D9TDA3_MICAI (D9TDA3)	1e-125	453	68%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	Micau_1179	Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)	4.2.1.46 niceE keggE
23	E8S5H3_MICSL (E8S5H3)	1e-125	452	68%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	ML5_1442	Micromonospora sp. (strain L5)	4.2.1.46 niceE keggE
24	B4VAI6_9ACTO (B4VAI6)	1e-125	452	68%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	SSAG_04825	Streptomyces sp. Mg1	4.2.1.46 niceE keggE
25	A8KQL1_9ACTO (A8KQL1)	1e-124	448	66%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	rhaB	Streptomyces olivaceus	4.2.1.46 niceE keggE
26	Q8KRX3_9ACTO (Q8KRX3)	1e-123	447	69%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	nbmH	Streptomyces narbonensis	4.2.1.46 niceE keggE
27	A0LRX9_ACIC1 (A0LRX9)	1e-122	444	66%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	Acel_0415	Acidothermus cellulolyticus (strain ATCC 43068 / 11B)	4.2.1.46 niceE keggE
28	Q331R3_9ACTO (Q331R3)	1e-122	444	68%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	gerE	Streptomyces sp. KCTC 0041BP	4.2.1.46 niceE keggE
29	C8XIN5_NAKMY (C8XIN5)	1e-122	443	66%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	Namu_4211	Nakamurella multipartita (strain ATCC 700099 / DSM 44233 / JCM 9543 / Y-104) Microsphaera multipartita	4.2.1.46 niceE keggE
30	Q6AGM1_LEIXX (Q6AGM1)	1e-120	437	67%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	Lxx04910	Leifsonia xyli subsp. xyli	4.2.1.46 niceE keggE
31	Q0PY19_STRMY (Q0PY19)	1e-120	437	68%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	midB	Streptomyces mycarofaciens	4.2.1.46 niceE keggE
32	B5H782_STRPR (B5H782)	1e-120	436	68%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	SSDG_01263	Streptomyces pristinaespiralis ATCC 25486	4.2.1.46 niceE keggE
33	D6A3M1_9ACTO (D6A3M1)	1e-120	436	67%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	SSFG_04776	Streptomyces ghanaensis ATCC 14672	4.2.1.46 niceE keggE
34	D9Y1L8_9ACTO (D9Y1L8)	1e-120	436	68%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	SSRG_04187	Streptomyces griseoflavus Tu4000	4.2.1.46 niceE keggE
35	D7B022_NOCDD (D7B022)	1e-120	436	65%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	Ndas_4724	Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488) Actinomadura dassonvillei	4.2.1.46 niceE keggE
36	E5F142_9ACTO (E5F142)	1e-120	436	66%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	rmlB	Kitasatospora kifunensis	4.2.1.46 niceE keggE
37	E4NCQ6_KITSK (E4NCQ6)	1e-120	434	66%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	rmlB1 KSE_31770	Kitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054) Streptomyces setae	4.2.1.46 niceE keggE
38	F4F6Y4_VERMA (F4F6Y4)	1e-119	432	65%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	VAB18032_22795	Verrucosispora maris (strain AB-18-032)	4.2.1.46 niceE keggE
39	B5HXA7_9ACTO (B5HXA7)	1e-119	432	67%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	SSEG_09375	Streptomyces sviceus ATCC 29083	4.2.1.46 niceE keggE
40	C4RP68_9ACTO (C4RP68)	1e-119	432	65%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	MCAG_03631	Micromonospora sp. ATCC 39149	4.2.1.46 niceE keggE
41	C5J046_STRPE (C5J046)	1e-118	431	67%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	rmbB	Streptomyces peucetius ATCC 27952	4.2.1.46 niceE keggE
42	D9I0H4_9ACTO (D9I0H4)	1e-118	431	67%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	cpzDIII	Streptomyces sp. MK730-62F2	4.2.1.46 niceE keggE
43	B8Y4F0_STRAU (B8Y4F0)	1e-118	431	65%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	aur1T	Streptomyces aureofaciens	4.2.1.46 niceE keggE
44	A8Y8J5_STRAM (A8Y8J5)	1e-118	428	68%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	srm5	Streptomyces ambofaciens	4.2.1.46 niceE keggE
45	D9XDA8_STRVR (D9XDA8)	1e-117	427	67%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	SSQG_07273	Streptomyces viridochromogenes DSM 40736	4.2.1.46 niceE keggE
46	D2SG25_GEOOG (D2SG25)	1e-117	427	66%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	Gobs_4331	Geodermatophilus obscurus (strain ATCC 25078 / DSM 43160 / JCM 3152 / G-20)	4.2.1.46 niceE keggE
47	Q83NY1_TROW8 (Q83NY1)	1e-117	426	62%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	TW033	Tropheryma whipplei (strain TW08/27) Whipple's bacillus	4.2.1.46 niceE keggE
48	Q83H32_TROWT (Q83H32)	1e-117	426	62%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	rmlB TWT030 TWT_030	Tropheryma whipplei (strain Twist) Whipple's bacillus	4.2.1.46 niceE keggE
49	C0JWC1_9ACTO (C0JWC1)	1e-117	426	67%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	pokS2	Streptomyces diastatochromogenes	4.2.1.46 niceE keggE
50	D1XFK5_9ACTO (D1XFK5)	1e-117	425	66%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	SACTEDRAFT_1465	Streptomyces sp. SA3_actE	4.2.1.46 niceE keggE
51	Q9RMG0_STRGL (Q9RMG0)	1e-116	424	64%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	sgcA	Streptomyces globisporus	4.2.1.46 niceE keggE
52	E9L1H3_9ZZZZ (E9L1H3)	1e-116	422	65%	UniProt GenBank	Putative uncharacterized protein	CA37-29	uncultured organism CA37
53	Q54144_STRFR (Q54144)	1e-116	422	65%	UniProt GenBank	dTDP-glucose 4,6-dehydratase		Streptomyces fradiae Streptomyces roseoflavus	4.2.1.46 niceE keggE
54	D9UBQ9_STRPR (D9UBQ9)	1e-115	421	67%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	cpp25	Streptomyces pristinaespiralis	4.2.1.46 niceE keggE
55	B5HIU1_STRPR (B5HIU1)	1e-115	421	67%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	SSDG_05078	Streptomyces pristinaespiralis ATCC 25486	4.2.1.46 niceE keggE
56	A8WEY5_STRST (A8WEY5)	1e-115	420	63%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	spcE	Streptomyces spectabilis	4.2.1.46 niceE keggE
57	Q9RR28_STRAT (Q9RR28)	1e-115	419	64%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	oleE	Streptomyces antibioticus	4.2.1.46 niceE keggE
58	E3T495_9ACTO (E3T495)	1e-115	418	65%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	gra-orf17	Streptomyces vietnamensis	4.2.1.46 niceE keggE
59	C4NYL8_9ACTO (C4NYL8)	1e-114	417	64%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	saqH	Micromonospora sp. Tu 6368	4.2.1.46 niceE keggE
60	Q3S887_9ACTO (Q3S887)	1e-114	417	65%	UniProt GenBank	dTDP-glucose 4,6-dehydratase		Streptomyces neyagawaensis	4.2.1.46 niceE keggE
61	Q83WG8_9ACTO (Q83WG8)	1e-114	417	64%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	staB	Streptomyces sp. TP-A0274	4.2.1.46 niceE keggE
62	Q9ZGC7_STRCY (Q9ZGC7)	1e-114	416	65%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	lanH14	Streptomyces cyanogenus	4.2.1.46 niceE keggE
63	Q9L6C3_STRAT (Q9L6C3)	1e-114	416	66%	UniProt GenBank	dTDP-glucose 4,6-dehydratase		Streptomyces antibioticus	4.2.1.46 niceE keggE
64	Q0R4N2_STRAT (Q0R4N2)	1e-114	415	63%	UniProt GenBank	dTDP-glucose 4,6-dehydratase		Streptomyces antibioticus	4.2.1.46 niceE keggE
65	D1H0B0_9ACTO (D1H0B0)	1e-114	415	66%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	chryE	Streptomyces albaduncus	4.2.1.46 niceE keggE
66	E1CG47_9ACTO (E1CG47)	1e-114	415	64%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	capQ	Streptomyces sp. SANK 62799	4.2.1.46 niceE keggE
67	Q194R3_STRAA (Q194R3)	1e-114	414	67%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	mtmE	Streptomyces argillaceus	4.2.1.46 niceE keggE
68	Q9KK63_STRRY (Q9KK63)	1e-113	414	66%	UniProt GenBank	DTDP-glucose 4,6-dehydratase	prmE	Streptomyces rimosus subsp. paromomycinus
69	Q8RS23_STRVL (Q8RS23)	1e-113	414	65%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	rhoH	Streptomyces violaceus Streptomyces venezuelae	4.2.1.46 niceE keggE
70	O05172_STRVR (O05172)	1e-113	412	60%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	aviE1	Streptomyces viridochromogenes	4.2.1.46 niceE keggE
71	C9YYJ5_STRSW (C9YYJ5)	1e-113	412	64%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	SCAB_84041	Streptomyces scabies (strain 87.22) Streptomyces scabiei	4.2.1.46 niceE keggE
72	D2B1Y0_STRRD (D2B1Y0)	1e-113	412	62%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	Sros_6490	Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)	4.2.1.46 niceE keggE
73	Q7WT24_9ACTO (Q7WT24)	1e-112	410	60%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	med-ORF17	Streptomyces sp. AM-7161	4.2.1.46 niceE keggE
74	D2B4G9_STRRD (D2B4G9)	1e-112	410	63%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	Sros_0632	Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)	4.2.1.46 niceE keggE
75	C7G1T6_STRGR (C7G1T6)	1e-112	410	66%	UniProt GenBank	dTDP-glucose 4,6-dehydratase		Streptomyces griseus	4.2.1.46 niceE keggE
76	D7BSN0_STRBB (D7BSN0)	1e-112	410	65%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	nanG2 SBI_08409	Streptomyces bingchenggensis (strain BCW-1)	4.2.1.46 niceE keggE
77	Q2PZR3_9ACTO (Q2PZR3)	1e-112	410	64%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	cosH	Streptomyces olindensis	4.2.1.46 niceE keggE
78	Q7WTE5_9ACTO (Q7WTE5)	1e-112	409	65%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	nanG2	Streptomyces nanchangensis	4.2.1.46 niceE keggE
79	Q76KZ7_STRHA (Q76KZ7)	1e-112	408	67%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	vinB	Streptomyces halstedii	4.2.1.46 niceE keggE
80	E4N8V2_KITSK (E4N8V2)	1e-112	408	65%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	rmlB2 KSE_18080	Kitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054) Streptomyces setae	4.2.1.46 niceE keggE
81	Q30CS6_STRAU (Q30CS6)	1e-112	408	64%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	lipDig2	Streptomyces aureofaciens	4.2.1.46 niceE keggE
82	B5H2M7_STRCL (B5H2M7)	1e-112	408	65%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	staB SCLAV_p1121 SSCG_05850	Streptomyces clavuligerus ATCC 27064	4.2.1.46 niceE keggE
83	D6MSX9_9ACTO (D6MSX9)	1e-111	407	64%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	ssfS2	Streptomyces sp. SF2575	4.2.1.46 niceE keggE
84	C7QIW6_CATAD (C7QIW6)	1e-111	407	63%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	Caci_8193	Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)	4.2.1.46 niceE keggE
85	Q9S1L0_STRNE (Q9S1L0)	1e-111	407	62%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	spcJ	Streptoverticillium netropsis Streptoverticillium flavopersicus	4.2.1.46 niceE keggE
86	D7BZT0_STRBB (D7BZT0)	1e-111	407	64%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	SBI_06865	Streptomyces bingchenggensis (strain BCW-1)	4.2.1.46 niceE keggE
87	Q83X80_STRRO (Q83X80)	1e-111	407	64%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	lkmD	Streptomyces rochei Streptomyces parvullus	4.2.1.46 niceE keggE
88	F2RC33_STRVP (F2RC33)	1e-111	406	66%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	SVEN_5998	Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)	4.2.1.46 niceE keggE
89	D9WEH5_9ACTO (D9WEH5)	1e-111	405	64%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	SSOG_02928	Streptomyces himastatinicus ATCC 53653	4.2.1.46 niceE keggE
90	D1A6U0_THECD (D1A6U0)	1e-111	405	62%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	Tcur_2799	Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)	4.2.1.46 niceE keggE
91	A0ADF0_STRAM (A0ADF0)	1e-111	404	63%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	SAMR0797	Streptomyces ambofaciens ATCC 23877	4.2.1.46 niceE keggE
92	F8K053_STRCT (F8K053)	1e-110	404	63%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	strE SCAT_2478	Streptomyces cattleya	4.2.1.46 niceE keggE
93	Q2HR54_9ACTO (Q2HR54)	1e-110	404	61%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	schS5	Streptomyces sp. SCC 2136	4.2.1.46 niceE keggE
94	D9W4I2_9ACTO (D9W4I2)	1e-110	402	65%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	SSNG_07062	Streptomyces sp. C	4.2.1.46 niceE keggE
95	Q9RPA5_STRFR (Q9RPA5)	1e-110	402	62%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	urdH	Streptomyces fradiae Streptomyces roseoflavus	4.2.1.46 niceE keggE
96	B1VRP9_STRGG (B1VRP9)	1e-109	400	62%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	SGR_638	Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)	4.2.1.46 niceE keggE
97	Q9X5W0_STRGR (Q9X5W0)	1e-109	400	62%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	grsE	Streptomyces griseus	4.2.1.46 niceE keggE
98	Q7X2H7_9ACTO (Q7X2H7)	1e-109	400	63%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	gilE	Streptomyces griseoflavus	4.2.1.46 niceE keggE
99	D1GLU6_9ACTO (D1GLU6)	1e-109	400	61%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	slgS2	Streptomyces lydicus	4.2.1.46 niceE keggE
100	Q56173_STRVN (Q56173)	1e-109	399	64%	UniProt GenBank	dTDP-glucose 4,6-dehydratase	graE gra-orf17	Streptomyces violaceoruber	4.2.1.46 niceE keggE

accession

alignment

Evalue

Score

Ident.

link

information

pubmed

Q9S0P5_STRAW
(Q9S0P5)

0.0

719

100%

Product: dTDP-glucose 4,6-dehydratase
Gene: aveBII
SAV946
SAV_946
Organism: Streptomyces avermitilis

[pubmed all]
1uniprot[Pubmed] 10449723 [Medline] 99380548 Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis.(Proc. Natl. Acad. Sci. U.S.A.) [1999]
2uniprot[Pubmed] 11572948 [Medline] 21477403 Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.(Proc. Natl. Acad. Sci. U.S.A.) [2001]
3uniprot[Pubmed] 12692562 [Medline] 22608306 Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis.(Nat. Biotechnol.) [2003]

Q9F5R6_STRSD
(Q9F5R6)

1e-141

504

76%

Product: dTDP-glucose 4,6-dehydratase
Gene
Organism: Streptomyces sp. (strain ATCC 17920 / DSM 40477 / NCIB 11028)
Streptomyces tenebrarius

1uniprot[Pubmed] 11517612 [Medline] 21409420
Cloning of the sugar related biosynthesis gene cluster from Streptomyces tenebrarius H6(Sheng Wu Gong Cheng Xue Bao) [2001]

C7MUW7_SACVD
(C7MUW7)

1e-140

504

73%

Product: dTDP-glucose 4,6-dehydratase
Gene: Svir_06090
Organism: Saccharomonospora viridis (strain ATCC 15386 / DSM 43017 / JCM 3036 / NBRC 12207 / P101)

1uniprot
Complete genome sequence of Saccharomonospora viridis type strain (P101T).(Stand. Genomic Sci.) [2009]

C6WJ73_ACTMD
(C6WJ73)

1e-138

497

74%

Product: dTDP-glucose 4,6-dehydratase
Gene: Amir_6347
Organism: Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971)

1uniprot
Complete genome sequence of Actinosynnema mirum type strain (101).(Stand. Genomic Sci.) [2009]

D8I3S0_AMYMU
(D8I3S0)

1e-138

494

74%

Product: dTDP-glucose 4,6-dehydratase
Gene: rfbB
AMED_1007
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

A0ACJ2_STRAM
(A0ACJ2)

1e-137

492

73%

Product: dTDP-glucose 4,6-dehydratase
Gene: SAMR0486
Organism: Streptomyces ambofaciens ATCC 23877

1uniprot[Pubmed] 16956972
Evolution of the terminal regions of the Streptomyces linear chromosome.(Mol. Biol. Evol.) [2006]

2uniprot
Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877.(Microbiology (Mosc.)) [2006]

A4FNM4_SACEN
(A4FNM4)

1e-134

481

70%

Product: dTDP-glucose 4,6-dehydratase
Gene: aveBII
SACE_6480
Organism: Saccharopolyspora erythraea (strain NRRL 23338)

1uniprot[Pubmed] 17369815
Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007]

Q54116_SACER
(Q54116)

1e-134

481

70%

Product: dTDP-glucose 4,6-dehydratase
Gene: gdh
Organism: Saccharopolyspora erythraea
Streptomyces erythraeus

1uniprot[Pubmed] 7883182 [Medline] 95189100
Cloning of the genes encoding thymidine diphosphoglucose 4,6-dehydratase and thymidine diphospho-4-keto-6-deoxyglucose 3,5-epimerase from the erythromycin-producing Saccharopolyspora erythraea.(Gene) [1995]

Q93EK0_9PSEU
(Q93EK0)

1e-134

481

71%

Product: dTDP-glucose 4,6-dehydratase
Gene: gdh
Organism: Saccharopolyspora spinosa

1uniprot[Pubmed] 11544225 [Medline] 21429236
Rhamnose biosynthesis pathway supplies precursors for primary and secondary metabolism in Saccharopolyspora spinosa.(J. Bacteriol.) [2001]

Q83WD7_MICGR
(Q83WD7)

1e-131

473

71%

Product: dTDP-glucose 4,6-dehydratase
Gene: mydB
Organism: Micromonospora griseorubida

1uniprot[Pubmed] 12583909 [Medline] 22472038
Organization of the biosynthetic gene cluster for the polyketide macrolide mycinamicin in Micromonospora griseorubida.(FEMS Microbiol. Lett.) [2003]

B3TMR2_9ACTO
(B3TMR2)

1e-131

471

69%

Product: dTDP-glucose 4,6-dehydratase
Gene: KijD4
Organism: Actinomadura kijaniata

1uniprot[Pubmed] 17985890
Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007]

Q5SFD3_STRBI
(Q5SFD3)

1e-127

457

69%

Product: dTDP-glucose 4,6-dehydratase
Gene: chmAII
Organism: Streptomyces bikiniensis

1uniprot[Pubmed] 15561847
Chalcomycin biosynthesis gene cluster from Streptomyces bikiniensis: novel features of an unusual ketolide produced through expression of the chm polyketide synthase in Streptomyces fradiae.(Antimicrob. Agents Chemother.) [2004]

B5L6K3_MICCH
(B5L6K3)

1e-126

456

69%

Product: dTDP-glucose 4,6-dehydratase
Gene
Organism: Micromonospora chalcea

1uniprot[Pubmed] 18586939
Cloning and characterization of the tetrocarcin A gene cluster from Micromonospora chalcea NRRL 11289 reveals a highly conserved strategy for tetronate biosynthesis in spirotetronate antibiotics.(J. Bacteriol.) [2008]

B0RDV6_CLAMS
(B0RDV6)

1e-126

456

70%

Product: dTDP-glucose 4,6-dehydratase
Gene: CMS0629
Organism: Clavibacter michiganensis subsp. sepedonicus (strain ATCC 33113 / JCM 9667)

1uniprot[Pubmed] 18192393
Genome of the actinomycete plant pathogen Clavibacter michiganensis subsp. sepedonicus suggests recent niche adaptation.(J. Bacteriol.) [2008]

Q9ZGH3_9ACTO
(Q9ZGH3)

1e-126

455

69%

Product: dTDP-glucose 4,6-dehydratase
Gene: desIV
Organism: Streptomyces venezuelae

[pubmed all]
1uniprot[Pubmed] 9770448 [Medline] 98445333 A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity.(Proc. Natl. Acad. Sci. U.S.A.) [1998]
2uniprot[Pubmed] 14570895 High resolution X-ray structure of dTDP-glucose 4,6-dehydratase from Streptomyces venezuelae.(J. Biol. Chem.) [2004]

A5CPQ0_CLAM3
(A5CPQ0)

1e-126

455

69%

Product: dTDP-glucose 4,6-dehydratase
Gene: rmlB
CMM_1010
Organism: Clavibacter michiganensis subsp. michiganensis (strain NCPPB 382)

1uniprot[Pubmed] 18192381
The genome sequence of the tomato-pathogenic actinomycete Clavibacter michiganensis subsp. michiganensis NCPPB382 reveals a large island involved in pathogenicity.(J. Bacteriol.) [2008]

A8KQL1_9ACTO
(A8KQL1)

1e-124

448

66%

Product: dTDP-glucose 4,6-dehydratase
Gene: rhaB
Organism: Streptomyces olivaceus

1uniprot[Pubmed] 18310024
Biosynthesis of elloramycin in Streptomyces olivaceus requires glycosylation by enzymes encoded outside the aglycon cluster.(Microbiology) [2008]

Q331R3_9ACTO
(Q331R3)

1e-122

444

68%

Product: dTDP-glucose 4,6-dehydratase
Gene: gerE
Organism: Streptomyces sp. KCTC 0041BP

1uniprot[Pubmed] 17053005
Biosynthesis of dTDP-6-deoxy-beta-D-allose, biochemical characterization of dTDP-4-keto-6-deoxyglucose reductase (GerKI) from Streptomyces sp. KCTC 0041BP.(Glycobiology) [2007]

2uniprot
Cloning and characterization of a gene cluster for the production of the polyketide macrolide antibiotic dihydrochalcomycin in Streptomyces sp. KCTC 0041BP.(J. Microbiol. Biotechnol.) [2006]

Q6AGM1_LEIXX
(Q6AGM1)

1e-120

437

67%

Product: dTDP-glucose 4,6-dehydratase
Gene: Lxx04910
Organism: Leifsonia xyli subsp. xyli

1uniprot[Pubmed] 15305603
The genome sequence of the Gram-positive sugarcane pathogen Leifsonia xyli subsp. xyli.(Mol. Plant Microbe Interact.) [2004]

Q0PY19_STRMY
(Q0PY19)

1e-120

437

68%

Product: dTDP-glucose 4,6-dehydratase
Gene: midB
Organism: Streptomyces mycarofaciens

1uniprot[Pubmed] 17342257
Cloning and characterization of genes encoded in dTDP-D-mycaminose biosynthetic pathway from a midecamycin-producing strain, Streptomyces mycarofaciens.(Acta Biochim. Biophys. Sin.) [2007]

D7B022_NOCDD
(D7B022)

1e-120

436

65%

Product: dTDP-glucose 4,6-dehydratase
Gene: Ndas_4724
Organism: Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei

1uniprot
Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010]

E5F142_9ACTO
(E5F142)

1e-120

436

66%

Product: dTDP-glucose 4,6-dehydratase
Gene: rmlB
Organism: Kitasatospora kifunensis

1uniprot[Pubmed] 20667525
Cloning and in vitro characterization of dTDP-6-deoxy-L-talose biosynthetic genes from Kitasatospora kifunensis featuring the dTDP-6-deoxy-L-lyxo-4-hexulose reductase that synthesizes dTDP-6-deoxy-L-talose.(Carbohydr. Res.) [2010]

E4NCQ6_KITSK
(E4NCQ6)

1e-120

434

66%

Product: dTDP-glucose 4,6-dehydratase
Gene: rmlB1
KSE_31770
Organism: Kitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054)
Streptomyces setae

1uniprot[Pubmed] 21059706
Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary snapshot of the family Streptomycetaceae.(DNA Res.) [2010]

F4F6Y4_VERMA
(F4F6Y4)

1e-119

432

65%

Product: dTDP-glucose 4,6-dehydratase
Gene: VAB18032_22795
Organism: Verrucosispora maris (strain AB-18-032)

1uniprot[Pubmed] 21551311
Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.(J. Bacteriol.) [2011]

D9I0H4_9ACTO
(D9I0H4)

1e-118

431

67%

Product: dTDP-glucose 4,6-dehydratase
Gene: cpzDIII
Organism: Streptomyces sp. MK730-62F2

1uniprot[Pubmed] 20418426
Formation and attachment of the deoxysugar moiety and assembly of the gene cluster for caprazamycin biosynthesis.(Appl. Environ. Microbiol.) [2010]

B8Y4F0_STRAU
(B8Y4F0)

1e-118

431

65%

Product: dTDP-glucose 4,6-dehydratase
Gene: aur1T
Organism: Streptomyces aureofaciens

1uniprot[Pubmed] 20490753
Identification and characterization of an indigoidine-like gene for a blue pigment biosynthesis in Streptomyces aureofaciens CCM 3239.(Folia Microbiol. (Praha)) [2010]

A8Y8J5_STRAM
(A8Y8J5)

1e-118

428

68%

Product: dTDP-glucose 4,6-dehydratase
Gene: srm5
Organism: Streptomyces ambofaciens

1uniprot
Organization of the biosynthetic gene cluster for the macrolide antibiotic spiramycin in Streptomyces ambofaciens.(Microbiology (Mosc.)) [2007]

Q83NY1_TROW8
(Q83NY1)

1e-117

426

62%

Product: dTDP-glucose 4,6-dehydratase
Gene: TW033
Organism: Tropheryma whipplei (strain TW08/27)
Whipple's bacillus

1uniprot[Pubmed] 12606174 [Medline] 22495039
Sequencing and analysis of the genome of the Whipple's disease bacterium Tropheryma whipplei.(Lancet) [2003]

Q83H32_TROWT
(Q83H32)

1e-117

426

62%

Product: dTDP-glucose 4,6-dehydratase
Gene: rmlB
TWT030
TWT_030
Organism: Tropheryma whipplei (strain Twist)
Whipple's bacillus

1uniprot[Pubmed] 12902375 [Medline] 22784088
Tropheryma whipplei twist: a human pathogenic Actinobacteria with a reduced genome.(Genome Res.) [2003]

C0JWC1_9ACTO
(C0JWC1)

1e-117

426

67%

Product: dTDP-glucose 4,6-dehydratase
Gene: pokS2
Organism: Streptomyces diastatochromogenes

1uniprot[Pubmed] 19266534
Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009]

Q9RMG0_STRGL
(Q9RMG0)

1e-116

424

64%

Product: dTDP-glucose 4,6-dehydratase
Gene: sgcA
Organism: Streptomyces globisporus

[pubmed all]
1uniprot[Pubmed] 10639366 [Medline] 20106985 Genes for production of the enediyne antitumor antibiotic C-1027 in Streptomyces globisporus are clustered with the cagA gene that encodes the C-1027 apoprotein.(Antimicrob. Agents Chemother.) [2000]
2uniprot[Pubmed] 12183628 [Medline] 22171413 Biosynthesis of the enediyne antitumor antibiotic C-1027.(Science) [2002]

E9L1H3_9ZZZZ
(E9L1H3)

1e-116

422

65%

Product: Putative uncharacterized protein
Gene: CA37-29
Organism: uncultured organism CA37

1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]

Q54144_STRFR
(Q54144)

1e-116

422

65%

Product: dTDP-glucose 4,6-dehydratase
Gene
Organism: Streptomyces fradiae
Streptomyces roseoflavus

1uniprot[Pubmed] 7984112 [Medline] 95075319
Analysis of five tylosin biosynthetic genes from the tyllBA region of the Streptomyces fradiae genome.(Mol. Microbiol.) [1994]

D9UBQ9_STRPR
(D9UBQ9)

1e-115

421

67%

Product: dTDP-glucose 4,6-dehydratase
Gene: cpp25
Organism: Streptomyces pristinaespiralis

1uniprot[Pubmed] 21342465
Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011]

A8WEY5_STRST
(A8WEY5)

1e-115

420

63%

Product: dTDP-glucose 4,6-dehydratase
Gene: spcE
Organism: Streptomyces spectabilis

[pubmed all]
1uniprot[Pubmed] 10650224 [Medline] 20117819 An efficient approach for cloning the dNDP-glucose synthase gene from actinomycetes and its application in Streptomyces spectabilis, a spectinomycin producer.(FEMS Microbiol. Lett.) [2000]
2uniprot[Pubmed] 18663525 The Gene Cluster for Spectinomycin Biosynthesis and the Aminoglycoside-Resistance Function of spcM in Streptomyces spectabilis.(Curr. Microbiol.) [2008]

Q9RR28_STRAT
(Q9RR28)

1e-115

419

64%

Product: dTDP-glucose 4,6-dehydratase
Gene: oleE
Organism: Streptomyces antibioticus

1uniprot[Pubmed] 10770761 [Medline] 20233594
Identification and expression of genes involved in biosynthesis of L-oleandrose and its intermediate L-olivose in the oleandomycin producer Streptomyces antibioticus.(Antimicrob. Agents Chemother.) [2000]

C4NYL8_9ACTO
(C4NYL8)

1e-114

417

64%

Product: dTDP-glucose 4,6-dehydratase
Gene: saqH
Organism: Micromonospora sp. Tu 6368

[pubmed all]
1uniprot[Pubmed] 17497146 A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]
2uniprot[Pubmed] 19384899 Cloning and sequencing of the biosynthetic gene cluster for saquayamycin z and galtamycin B and the elucidation of the assembly of their saccharide chains.(Chembiochem) [2009]

Q3S887_9ACTO
(Q3S887)

1e-114

417

65%

Product: dTDP-glucose 4,6-dehydratase
Gene
Organism: Streptomyces neyagawaensis

1uniprot[Pubmed] 16207901
Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449.(Microbiology) [2005]

Q83WG8_9ACTO
(Q83WG8)

1e-114

417

64%

Product: dTDP-glucose 4,6-dehydratase
Gene: staB
Organism: Streptomyces sp. TP-A0274

[pubmed all]
1uniprot Direct formation of chromopyrrolic acid from indole-3-pyruvic acid by StaD, a novel hemoprotein in indolocarbazole biosynthesis.(Tetrahedron Lett.) [2006]
2uniprot Biosynthesis of heterocyclic antibiotics in actinomycetes and an approach to synthesize the natural compounds.(Nihon Hosenkin Gakkaishi) [2006]
3uniprot[Pubmed] 12617516 [Medline] 22504382 Cloning of the staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274 and its heterologous expression in Streptomyces lividans.(J. Antibiot.) [2002]
4uniprot Characterization of the biosynthetic gene cluster of rebecamycin from Lechevalieria aerocolonigenes ATCC 39243.(Biosci. Biotechnol. Biochem.) [2003]
5uniprot[Pubmed] 16195595 Cytochrome P450 homolog is responsible for C-N bond formation between aglycone and deoxysugar in the staurosporine biosynthesis of Streptomyces sp. TP-A0274.(Biosci. Biotechnol. Biochem.) [2005]

Q9ZGC7_STRCY
(Q9ZGC7)

1e-114

416

65%

Product: dTDP-glucose 4,6-dehydratase
Gene: lanH14
Organism: Streptomyces cyanogenus

1uniprot[Pubmed] 9933932 [Medline] 99132695
Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin biosynthesis.(FEMS Microbiol. Lett.) [1999]

Q9L6C3_STRAT
(Q9L6C3)

1e-114

416

66%

Product: dTDP-glucose 4,6-dehydratase
Gene
Organism: Streptomyces antibioticus

1uniprot
Mechanism of the 2-deoxygenation step in the biosynthesis of the deoxyhexose moieties of the antibiotics granaticin and oleandomycin.(J. Am. Chem. Soc.) [1999]

Q0R4N2_STRAT
(Q0R4N2)

1e-114

415

63%

Product: dTDP-glucose 4,6-dehydratase
Gene
Organism: Streptomyces antibioticus

1uniprot[Pubmed] 16793515
Genetic characterization of the chlorothricin gene cluster as a model for spirotetronate antibiotic biosynthesis.(Chem. Biol.) [2006]

Q194R3_STRAA
(Q194R3)

1e-114

414

67%

Product: dTDP-glucose 4,6-dehydratase
Gene: mtmE
Organism: Streptomyces argillaceus

[pubmed all]
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]

O05172_STRVR
(O05172)

1e-113

412

60%

Product: dTDP-glucose 4,6-dehydratase
Gene: aviE1
Organism: Streptomyces viridochromogenes

[pubmed all]
1uniprot[Pubmed] 8768522 [Medline] 96313316 A general approach for cloning and characterizing dNDP-glucose dehydratase genes from actinomycetes.(FEMS Microbiol. Lett.) [1996]
2uniprot[Pubmed] 9335272 [Medline] 97474248 Cloning of an avilamycin biosynthetic gene cluster from Streptomyces viridochromogenes Tu57.(J. Bacteriol.) [1997]
3uniprot[Pubmed] 11410376 [Medline] 21303144 Biosynthesis of the orthosomycin antibiotic avilamycin A: deductions from the molecular analysis of the avi biosynthetic gene cluster of Streptomyces viridochromogenes Tu57 and production of new antibiotics.(Chem. Biol.) [2001]
4uniprot[Pubmed] 15489167 Novel avilamycin derivatives with improved polarity generated by targeted gene disruption.(Chem. Biol.) [2004]

C9YYJ5_STRSW
(C9YYJ5)

1e-113

412

64%

Product: dTDP-glucose 4,6-dehydratase
Gene: SCAB_84041
Organism: Streptomyces scabies (strain 87.22)
Streptomyces scabiei

1uniprot[Pubmed] 20064060
Streptomyces scabies 87-22 contains a coronafacic acid-like biosynthetic cluster that contributes to plant-microbe interactions.(Mol. Plant Microbe Interact.) [2010]

D2B1Y0_STRRD
(D2B1Y0)

1e-113

412

62%

Product: dTDP-glucose 4,6-dehydratase
Gene: Sros_6490
Organism: Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)

1uniprot
Complete genome sequence of Streptosporangium roseum type strain (NI 9100T).(Stand. Genomic Sci.) [2010]

Q7WT24_9ACTO
(Q7WT24)

1e-112

410

60%

Product: dTDP-glucose 4,6-dehydratase
Gene: med-ORF17
Organism: Streptomyces sp. AM-7161

1uniprot
Cloning, sequencing and heterologous expression of the medermycin biosynthetic gene cluster of Streptomyces sp. AM-7161: towards comparative analysis of the benzoisochromanequione gene clusters.(Microbiology (Mosc.)) [2003]

D2B4G9_STRRD
(D2B4G9)

1e-112

410

63%

Product: dTDP-glucose 4,6-dehydratase
Gene: Sros_0632
Organism: Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)

1uniprot
Complete genome sequence of Streptosporangium roseum type strain (NI 9100T).(Stand. Genomic Sci.) [2010]

C7G1T6_STRGR
(C7G1T6)

1e-112

410

66%

Product: dTDP-glucose 4,6-dehydratase
Gene
Organism: Streptomyces griseus

1uniprot
Identification of the biosynthetic gene cluster of A-500359s in Streptomyces griseus SANK60196.(J. Antibiot.) [2009]

D7BSN0_STRBB
(D7BSN0)

1e-112

410

65%

Product: dTDP-glucose 4,6-dehydratase
Gene: nanG2
SBI_08409
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

Q2PZR3_9ACTO
(Q2PZR3)

1e-112

410

64%

Product: dTDP-glucose 4,6-dehydratase
Gene: cosH
Organism: Streptomyces olindensis

1uniprot[Pubmed] 16810496
Insights in the glycosylation steps during biosynthesis of the antitumor anthracycline cosmomycin: characterization of two glycosyltransferase genes.(Appl. Microbiol. Biotechnol.) [2006]

Q7WTE5_9ACTO
(Q7WTE5)

1e-112

409

65%

Product: dTDP-glucose 4,6-dehydratase
Gene: nanG2
Organism: Streptomyces nanchangensis

1uniprot[Pubmed] 12770825 [Medline] 22654646
A complete gene cluster from Streptomyces nanchangensis NS3226 encoding biosynthesis of the polyether ionophore nanchangmycin.(Chem. Biol.) [2003]

Q76KZ7_STRHA
(Q76KZ7)

1e-112

408

67%

Product: dTDP-glucose 4,6-dehydratase
Gene: vinB
Organism: Streptomyces halstedii

1uniprot[Pubmed] 15112997
Cloning, sequencing, and functional analysis of the biosynthetic gene cluster of macrolactam antibiotic vicenistatin in Streptomyces halstedii.(Chem. Biol.) [2004]

E4N8V2_KITSK
(E4N8V2)

1e-112

408

65%

Product: dTDP-glucose 4,6-dehydratase
Gene: rmlB2
KSE_18080
Organism: Kitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054)
Streptomyces setae

1uniprot[Pubmed] 21059706
Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary snapshot of the family Streptomycetaceae.(DNA Res.) [2010]

Q30CS6_STRAU
(Q30CS6)

1e-112

408

64%

Product: dTDP-glucose 4,6-dehydratase
Gene: lipDig2
Organism: Streptomyces aureofaciens

1uniprot[Pubmed] 16723573
Biosynthetic gene cluster for the polyenoyltetramic acid alpha-lipomycin.(Antimicrob. Agents Chemother.) [2006]

B5H2M7_STRCL
(B5H2M7)

1e-112

408

65%

Product: dTDP-glucose 4,6-dehydratase
Gene: staB
SCLAV_p1121
SSCG_05850
Organism: Streptomyces clavuligerus ATCC 27064

1uniprot
The sequence of a 1.8 Mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.(Genome Biol. Evol.) [2010]

D6MSX9_9ACTO
(D6MSX9)

1e-111

407

64%

Product: dTDP-glucose 4,6-dehydratase
Gene: ssfS2
Organism: Streptomyces sp. SF2575

1uniprot[Pubmed] 19908837
Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.(J. Am. Chem. Soc.) [2009]

C7QIW6_CATAD
(C7QIW6)

1e-111

407

63%

Product: dTDP-glucose 4,6-dehydratase
Gene: Caci_8193
Organism: Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)

1uniprot
Complete genome sequence of Catenulispora acidiphila type strain (ID 139908).(Stand. Genomic Sci.) [2009]

D7BZT0_STRBB
(D7BZT0)

1e-111

407

64%

Product: dTDP-glucose 4,6-dehydratase
Gene: SBI_06865
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

Q83X80_STRRO
(Q83X80)

1e-111

407

64%

Product: dTDP-glucose 4,6-dehydratase
Gene: lkmD
Organism: Streptomyces rochei
Streptomyces parvullus

[pubmed all]
1uniprot[Pubmed] 12791134 [Medline] 22676866 The large linear plasmid pSLA2-L of Streptomyces rochei has an unusually condensed gene organization for secondary metabolism.(Mol. Microbiol.) [2003]
2uniprot[Pubmed] 10954087 [Medline] 20408175 Cloning and analysis of the replication origin and the telomeres of the large linear plasmid pSLA2-L in Streptomyces rochei.(Mol. Gen. Genet.) [2000]
3uniprot[Pubmed] 10767533 [Medline] 20231737 Identification of two polyketide synthase gene clusters on the linear plasmid pSLA2-L in Streptomyces rochei.(Gene) [2000]
4uniprot[Pubmed] 9836424 [Medline] 99053144 Physical mapping of the linear plasmid pSLA2-L and localization of the eryAI and actI homologs.(Biosci. Biotechnol. Biochem.) [1998]

F2RC33_STRVP
(F2RC33)

1e-111

406

66%

Product: dTDP-glucose 4,6-dehydratase
Gene: SVEN_5998
Organism: Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)

1uniprot[Pubmed] 21463507
Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes.(BMC Genomics) [2011]

D1A6U0_THECD
(D1A6U0)

1e-111

405

62%

Product: dTDP-glucose 4,6-dehydratase
Gene: Tcur_2799
Organism: Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)

1uniprot
Complete genome sequence of Thermomonospora curvata type strain (B9).(Stand. Genomic Sci.) [2011]

A0ADF0_STRAM
(A0ADF0)

1e-111

404

63%

Product: dTDP-glucose 4,6-dehydratase
Gene: SAMR0797
Organism: Streptomyces ambofaciens ATCC 23877

1uniprot[Pubmed] 16956972
Evolution of the terminal regions of the Streptomyces linear chromosome.(Mol. Biol. Evol.) [2006]

2uniprot
Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877.(Microbiology (Mosc.)) [2006]

Q2HR54_9ACTO
(Q2HR54)

1e-110

404

61%

Product: dTDP-glucose 4,6-dehydratase
Gene: schS5
Organism: Streptomyces sp. SCC 2136

1uniprot
Angucyclines Sch 47554 and Sch 47555 from Streptomyces sp. SCC-2136: Cloning, Sequencing, and Characterization.(Mol. Cells) [2006]

2uniprot
Molecular cloning and characterization of biosynthetic genes cluster of Sch 47554 from Streptomyces sp. SCC 2136. [2004]

Q9RPA5_STRFR
(Q9RPA5)

1e-110

402

62%

Product: dTDP-glucose 4,6-dehydratase
Gene: urdH
Organism: Streptomyces fradiae
Streptomyces roseoflavus

1uniprot[Pubmed] 10658661 [Medline] 20121748
Two new tailoring enzymes, a glycosyltransferase and an oxygenase, involved in biosynthesis of the angucycline antibiotic urdamycin A in Streptomyces fradiae Tu2717.(Microbiology) [2000]

B1VRP9_STRGG
(B1VRP9)

1e-109

400

62%

Product: dTDP-glucose 4,6-dehydratase
Gene: SGR_638
Organism: Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)

1uniprot[Pubmed] 18375553
Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350.(J. Bacteriol.) [2008]

Q7X2H7_9ACTO
(Q7X2H7)

1e-109

400

63%

Product: dTDP-glucose 4,6-dehydratase
Gene: gilE
Organism: Streptomyces griseoflavus

1uniprot[Pubmed] 12822997 [Medline] 22708304
The complete gene cluster of the antitumor agent gilvocarcin V and its implication for the biosynthesis of the gilvocarcins.(J. Am. Chem. Soc.) [2003]

D1GLU6_9ACTO
(D1GLU6)

1e-109

400

61%

Product: dTDP-glucose 4,6-dehydratase
Gene: slgS2
Organism: Streptomyces lydicus

1uniprot
Deciphering biosynthesis of the RNA polymerase inhibitor streptolydigin and generation of glycosylated derivatives.(Chem. Biol.) [2009]

100

Q56173_STRVN
(Q56173)

1e-109

399

64%

Product: dTDP-glucose 4,6-dehydratase
Gene: graE
gra-orf17
Organism: Streptomyces violaceoruber

[pubmed all]
1uniprot[Pubmed] 7476861 [Medline] 96027933 Identification of Streptomyces violaceoruber Tu22 genes involved in the biosynthesis of granaticin.(Mol. Gen. Genet.) [1995]
2uniprot[Pubmed] 2583128 [Medline] 90060034 Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber Tu22.(EMBO J.) [1989]
3uniprot[Pubmed] 9831526 [Medline] 99051446 The granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tu22: sequence analysis and expression in a heterologous host.(Chem. Biol.) [1998]