BLAST table : Enter_00080

DB	UniProtKB

	accession	Evalue	Score	Ident.	link	product	gene	organism	ec
1	Q9KHK7_9ACTO (Q9KHK7)	1e-153	545	100%	UniProt GenBank	Putative ketoreductase EncD	encD	Streptomyces maritimus
2	D6MSV3_9ACTO (D6MSV3)	3e-82	309	62%	UniProt GenBank	SsfU	ssfU	Streptomyces sp. SF2575
3	B5G888_9ACTO (B5G888)	1e-80	304	61%	UniProt GenBank	Monensin polyketide synthase ketoacyl reductase	SSBG_00496	Streptomyces sp. SPB74
4	E8W958_STRFA (E8W958)	2e-80	303	60%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	Sfla_5324	Streptomyces flavogriseus (strain ATCC 33331 / DSM 40990 / IAF-45CD)
5	A1C175_9ACTO (A1C175)	2e-79	300	62%	UniProt GenBank	Ketoreductase		Streptomyces echinatus
6	Q8VWB5_9ACTO (Q8VWB5)	2e-79	300	59%	UniProt GenBank	AknA	aknA	Streptomyces galilaeus
7	Q9L553_9ACTO (Q9L553)	2e-78	296	59%	UniProt GenBank	AknA	aknA	Streptomyces galilaeus
8	Q54190_9ACTO (Q54190)	3e-78	296	59%	UniProt GenBank	Ketoacyl reductase	aknIII	Streptomyces galilaeus	1.3.1.- niceE keggE
9	Q54176_STRFR (Q54176)	1e-76	290	58%	UniProt GenBank	Putative ketoreductase	UrdD	Streptomyces fradiae Streptomyces roseoflavus
10	A4X6Z5_SALTO (A4X6Z5)	2e-76	289	61%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	Strop_2194	Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
11	D2XDY2_9PSEU (D2XDY2)	3e-76	289	59%	UniProt GenBank	AzicD	azicD	Kibdelosporangium sp. MJ126-NF4
12	Q3S8Q6_STRRM (Q3S8Q6)	1e-75	287	60%	UniProt GenBank	OxyJ	oxyJ	Streptomyces rimosus
13	Q93LY1_9ACTO (Q93LY1)	2e-75	287	59%	UniProt GenBank	Polyketide ketoreductase PgaD	pgaD	Streptomyces sp. PGA64
14	C4NYK2_9ACTO (C4NYK2)	2e-75	286	58%	UniProt GenBank	SaqD	saqD	Micromonospora sp. Tu 6368
15	B5HT05_9ACTO (B5HT05)	2e-75	286	59%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase	SSEG_02722	Streptomyces sviceus ATCC 29083
16	Q9AMJ0_STRAT (Q9AMJ0)	2e-75	286	58%	UniProt GenBank	Putative ketoreductase SimA6 Sim5	simA6 sim5	Streptomyces antibioticus
17	D7BZR7_STRBB (D7BZR7)	1e-74	284	57%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	SBI_06852	Streptomyces bingchenggensis (strain BCW-1)
18	E8RWS2_MICSL (E8RWS2)	1e-74	283	59%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	ML5_4411	Micromonospora sp. (strain L5)
19	D9T2A7_MICAI (D9T2A7)	2e-74	283	59%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	Micau_4010	Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
20	C7QAF5_CATAD (C7QAF5)	3e-74	283	58%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	Caci_3549	Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
21	D1XRF2_9ACTO (D1XRF2)	3e-74	282	60%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	SACTEDRAFT_5262	Streptomyces sp. SA3_actE
22	Q47QL0_THEFY (Q47QL0)	4e-74	282	56%	UniProt GenBank	Ketoacyl reductase	Tfu_1221	Thermobifida fusca (strain YX)
23	Q54812_STRPE (Q54812)	5e-74	282	58%	UniProt GenBank	Daunorubicin-doxorubicin polyketide synthase	dpsE	Streptomyces peucetius
24	Q6ZZV9_STRAT (Q6ZZV9)	5e-74	281	58%	UniProt GenBank	Ketoreductase	ovmT	Streptomyces antibioticus
25	Q84CH9_9ACTO (Q84CH9)	5e-74	281	59%	UniProt GenBank	Putative ketoreductase	pd2E	Streptomyces sp. WP 4669
26	Q83X41_STRRO (Q83X41)	6e-74	281	58%	UniProt GenBank	Ketoreductase	rocG	Streptomyces rochei Streptomyces parvullus
27	D7RFJ8_AMYOR (D7RFJ8)	2e-73	280	57%	UniProt GenBank	Putative ketoreductase	bexD	Amycolatopsis orientalis subsp. vinearia
28	F2RC18_STRVP (F2RC18)	2e-73	280	56%	UniProt GenBank	Acetoacetyl-CoA reductase	SVEN_5983	Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)	1.1.1.36 niceE keggE
29	Q93LZ9_STRAU (Q93LZ9)	3e-73	279	57%	UniProt GenBank	Ketoreductase-like protein	aur2E	Streptomyces aureofaciens
30	DHKR_STRCM (P41177)	4e-73	279	57%	UniProt GenBank	Monensin polyketide synthase putative ketoacyl reductase ORF5		Streptomyces cinnamonensis	1.3.1.- niceE keggE
31	Q56H99_STRAU (Q56H99)	6e-73	278	57%	UniProt GenBank	Aur1G	aur1G	Streptomyces aureofaciens
32	Q84CJ4_9ACTO (Q84CJ4)	9e-73	278	59%	UniProt GenBank	Putative ketoreductase	kinE	Streptomyces murayamaensis
33	Q935Z6_9ACTO (Q935Z6)	1e-72	277	57%	UniProt GenBank	RdmJ	rdmJ	Streptomyces purpurascens
34	Q54491_STRNO (Q54491)	1e-72	277	57%	UniProt GenBank	SnoaD	snoaD	Streptomyces nogalater
35	D9UBK7_STRPR (D9UBK7)	2e-72	276	58%	UniProt GenBank	Putative ketoreductase	c104_08c	Streptomyces pristinaespiralis
36	B5HJY0_STRPR (B5HJY0)	2e-72	276	58%	UniProt GenBank	Ketoreductase	SSDG_05477	Streptomyces pristinaespiralis ATCC 25486
37	F6K0W2_9BACT (F6K0W2)	2e-72	276	57%	UniProt GenBank	Ketoreductase		uncultured bacterium BAC AB649/1850
38	Q2HR23_9ACTO (Q2HR23)	2e-72	276	57%	UniProt GenBank	Putative ketoreducatse	schP5	Streptomyces sp. SCC 2136
39	D9W5A8_9ACTO (D9W5A8)	2e-72	276	57%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase	SSNG_07338	Streptomyces sp. C
40	Q54280_SACHI (Q54280)	5e-72	275	56%	UniProt GenBank	Polyketide reductase		Saccharopolyspora hirsuta
41	Q55221_STRSQ (Q55221)	8e-72	274	57%	UniProt GenBank	Polyketide reductase	dauB	Streptomyces sp
42	Q56166_9ACTO (Q56166)	2e-71	273	55%	UniProt GenBank	Ketoreductase		Streptomyces venezuelae
43	D5MRI8_9ACTO (D5MRI8)	2e-71	273	58%	UniProt GenBank	Putative ketoreductase	hrbO	Streptomyces sp. 2238-SVT4
44	Q54220_STRGR (Q54220)	1e-70	271	56%	UniProt GenBank	Ketoreductase		Streptomyces griseus
45	D1A6T4_THECD (D1A6T4)	1e-70	270	57%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	Tcur_2793	Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
46	Q2J5J1_FRASC (Q2J5J1)	3e-70	269	58%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	Francci3_4103	Frankia sp. (strain CcI3)
47	E3J3Q6_FRASU (E3J3Q6)	4e-70	269	54%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	FraEuI1c_1326	Frankia sp. (strain EuI1c)
48	D6EWA8_STRLI (D6EWA8)	4e-70	269	53%	UniProt GenBank	Ketoacyl reductase	SSPG_02603	Streptomyces lividans TK24
49	ACT3_STRCO (P16544)	4e-70	269	53%	UniProt GenBank	Putative ketoacyl reductase	actIII SCO5086 SCBAC28G1.12c	Streptomyces coelicolor	1.3.1.- niceE keggE
50	Q6VMJ0_STRAM (Q6VMJ0)	8e-70	268	55%	UniProt GenBank	Polyketide ketoreductase Putative polyketide ketoreductase	alpD DSMT0182	Streptomyces ambofaciens
51	Q1RQS3_STRAM (Q1RQS3)	8e-70	268	55%	UniProt GenBank	Polyketide ketoreductase	alpD SAMT0162 SAMT0163	Streptomyces ambofaciens ATCC 23877
52	Q67G28_9ACTO (Q67G28)	3e-69	266	56%	UniProt GenBank	Keto reductase		Streptomyces griseoruber
53	Q4R0M6_STRCX (Q4R0M6)	3e-69	266	57%	UniProt GenBank	ChaD protein	chaD	Streptomyces chartreusis
54	Q9ZGD4_STRCY (Q9ZGD4)	3e-69	266	58%	UniProt GenBank	Reductase homolog	lanD	Streptomyces cyanogenus
55	D3U1V1_9BACT (D3U1V1)	4e-69	265	55%	UniProt GenBank	Keto reductase		uncultured soil bacterium V167
56	Q9FCM4_STRAT (Q9FCM4)	4e-69	265	54%	UniProt GenBank	Putative keto reductase		Streptomyces antibioticus
57	D3D3B6_9ACTO (D3D3B6)	5e-69	265	56%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	FrEUN1fDRAFT_4286	Frankia sp. EUN1f
58	D9UBR2_STRPR (D9UBR2)	9e-69	264	54%	UniProt GenBank	Putative ketoreductase	cpp22	Streptomyces pristinaespiralis	1.1.1.100 niceE keggE
59	B5HIU4_STRPR (B5HIU4)	9e-69	264	54%	UniProt GenBank	Polyketide ketoreductase	SSDG_05081	Streptomyces pristinaespiralis ATCC 25486
60	Q7WT12_9ACTO (Q7WT12)	1e-68	264	55%	UniProt GenBank	Keto reductase (KR)	med-ORF6	Streptomyces sp. AM-7161
61	B6SEF4_9ACTO (B6SEF4)	2e-68	263	58%	UniProt GenBank	AlnP ketoreductase	alnP	Streptomyces sp. CM020
62	Q7X2G2_9ACTO (Q7X2G2)	3e-68	262	55%	UniProt GenBank	Putative ketoreductase	gilF	Streptomyces griseoflavus
63	D9UKN7_9ACTO (D9UKN7)	9e-67	258	60%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase	SSLG_05753	Streptomyces sp. SPB78
64	E3T4A9_9ACTO (E3T4A9)	2e-66	257	54%	UniProt GenBank	Polyketide ketoreductase	gra-orf5	Streptomyces vietnamensis
65	Q54998_9ACTO (Q54998)	1e-65	254	59%	UniProt GenBank	Ketoreductase	frnP	Streptomyces roseofulvus
66	DHK1_STRVN (P16542)	5e-65	252	55%	UniProt GenBank	Granaticin polyketide synthase putative ketoacyl reductase 1 ORF5	gra-orf5	Streptomyces violaceoruber	1.3.1.- niceE keggE
67	D1H0K9_9ACTO (D1H0K9)	3e-64	249	57%	UniProt GenBank	Putative ketoreductase	ravF	Streptomyces sp. C23201NS3
68	D1H093_9ACTO (D1H093)	2e-63	246	55%	UniProt GenBank	Putative polyketide ketoreductase	chryF	Streptomyces albaduncus
69	Q4R0K8_STRCX (Q4R0K8)	6e-63	245	52%	UniProt GenBank	ChaZ protein	chaZ	Streptomyces chartreusis
70	C7PWR3_CATAD (C7PWR3)	4e-62	242	54%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	Caci_6493	Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
71	Q7MZT0_PHOLL (Q7MZT0)	1e-56	224	47%	UniProt GenBank	Similar to polyketide ketoreductase	plu4194	Photorhabdus luminescens subsp. laumondii (strain TT01)
72	Q53484_STRMY (Q53484)	2e-56	223	48%	UniProt GenBank	Polyketide ketoreductase	MPKR	Streptomyces mycarofaciens
73	Q2J5E8_FRASC (Q2J5E8)	2e-43	181	53%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	Francci3_4146	Frankia sp. (strain CcI3)
74	B7K8Q5_CYAP7 (B7K8Q5)	2e-42	177	43%	UniProt GenBank	3-oxoacyl-(Acyl-carrier-protein) reductase	PCC7424_2848	Cyanothece sp. (strain PCC 7424) Synechococcus sp. (strain ATCC 29155)
75	B4VS33_9CYAN (B4VS33)	3e-42	176	43%	UniProt GenBank	3-oxoacyl-(Acyl-carrier-protein) reductase	MC7420_2276	Microcoleus chthonoplastes PCC 7420	1.1.1.100 niceE keggE
76	Q481D0_COLP3 (Q481D0)	2e-40	170	42%	UniProt GenBank	Acetoacetyl-CoA reductase	phbB1 CPS_2625	Colwellia psychrerythraea (strain 34H / ATCC BAA-681) Vibrio psychroerythus	1.1.1.36 niceE keggE
77	E0UEL1_CYAP2 (E0UEL1)	8e-40	168	42%	UniProt GenBank	3-oxoacyl-(Acyl-carrier-protein) reductase	Cyan7822_4673	Cyanothece sp. (strain PCC 7822)
78	C7QTQ3_CYAP0 (C7QTQ3)	1e-39	167	42%	UniProt GenBank	3-oxoacyl-(Acyl-carrier-protein) reductase	Cyan8802_4325	Cyanothece sp. (strain PCC 8802) Synechococcus sp. (strain RF-2)
79	B7K6D5_CYAP8 (B7K6D5)	1e-39	167	42%	UniProt GenBank	3-oxoacyl-(Acyl-carrier-protein) reductase	PCC8801_4265	Cyanothece sp. (strain PCC 8801) Synechococcus sp. (strain PCC 8801 / RF-1)
80	Q7MD25_VIBVY (Q7MD25)	6e-39	165	41%	UniProt GenBank	Dehydrogenase	VVA1211	Vibrio vulnificus (strain YJ016)
81	Q8DIS9_THEEB (Q8DIS9)	1e-38	164	43%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase	tlr1502	Thermosynechococcus elongatus (strain BP-1)
82	D6U4J8_9CHLR (D6U4J8)	1e-38	164	42%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	Krac_2148	Ktedonobacter racemifer DSM 44963
83	B8IX34_METNO (B8IX34)	4e-38	162	41%	UniProt GenBank	3-hydroxybutyrate dehydrogenase	Mnod_8088	Methylobacterium nodulans (strain ORS2060 / LMG 21967)
84	E8VVC2_VIBVU (E8VVC2)	6e-38	162	40%	UniProt GenBank	Acetoacetyl-CoA reductase	VVMO6_04115	Vibrio vulnificus MO6-24/O	1.1.1.36 niceE keggE
85	Q2C8D5_9GAMM (Q2C8D5)	8e-38	161	42%	UniProt GenBank	Acetoacetyl-CoA reductase	SKA34_06315	Photobacterium sp. SKA34	1.1.1.36 niceE keggE
86	B8HRG1_CYAP4 (B8HRG1)	1e-37	161	44%	UniProt GenBank	3-oxoacyl-(Acyl-carrier-protein) reductase	Cyan7425_1782	Cyanothece sp. (strain PCC 7425 / ATCC 29141)
87	D4TKB0_9NOST (D4TKB0)	1e-37	160	42%	UniProt GenBank	3-oxoacyl-(Acyl-carrier-protein) reductase	fabG CRC_02805	Cylindrospermopsis raciborskii CS-505
88	C9P683_VIBME (C9P683)	1e-37	160	40%	UniProt GenBank	Acetoacetyl-CoA reductase	VIB_001812	Vibrio metschnikovii CIP 69.14	1.1.1.36 niceE keggE
89	D2RL00_ACIFV (D2RL00)	2e-37	160	41%	UniProt GenBank	3-oxoacyl-(Acyl-carrier-protein) reductase	Acfer_1392	Acidaminococcus fermentans (strain ATCC 25085 / DSM 20731 / VR4)
90	B0JMC7_MICAN (B0JMC7)	2e-37	160	40%	UniProt GenBank	3-oxoacyl-[acyl-carrier protein] reductase	MAE_33900	Microcystis aeruginosa (strain NIES-843)
91	A6B0K6_VIBPA (A6B0K6)	2e-37	160	40%	UniProt GenBank	Acetoacetyl-CoA reductase	A79_3719	Vibrio parahaemolyticus AQ3810	1.1.1.36 niceE keggE
92	A0YVK3_LYNSP (A0YVK3)	3e-37	159	41%	UniProt GenBank	3-ketoacyl-(Acyl-carrier-protein) reductase	fabG L8106_21814	Lyngbya sp. (strain PCC 8106) Lyngbya aestuarii (strain CCY9616)	1.1.1.100 niceE keggE
93	A8YML6_MICAE (A8YML6)	3e-37	159	40%	UniProt GenBank	FabG1 protein	fabG1 IPF_1599	Microcystis aeruginosa PCC 7806
94	D4TRN7_9NOST (D4TRN7)	4e-37	159	41%	UniProt GenBank	3-oxoacyl-(Acyl-carrier-like protein) reductase	fabG CRD_02288	Raphidiopsis brookii D9
95	A0ZJE3_NODSP (A0ZJE3)	5e-37	159	43%	UniProt GenBank	3-ketoacyl-(Acyl-carrier-protein) reductase	fabG N9414_22428	Nodularia spumigena CCY9414	1.1.1.100 niceE keggE
96	F5L7T7_9BACI (F5L7T7)	5e-37	159	42%	UniProt GenBank	3-oxoacyl-(Acyl-carrier-protein) reductase	CathTA2_1881	Caldalkalibacillus thermarum TA2.A1
97	A2C0R0_PROM1 (A2C0R0)	7e-37	158	39%	UniProt GenBank	3-oxoacyl-[acyl-carrier protein] reductase	NATL1_05081	Prochlorococcus marinus (strain NATL1A)	1.1.1.100 niceE keggE
98	Q6LKI6_PHOPR (Q6LKI6)	1e-36	157	42%	UniProt GenBank	Putative acetoacetyl-CoA reductase	XCC2294 PBPRB0350	Photobacterium profundum Photobacterium sp. (strain SS9)
99	B5YDQ2_DICT6 (B5YDQ2)	1e-36	157	39%	UniProt GenBank	3-oxoacyl-(Acyl-carrier-protein) reductase	fabG DICTH_0794	Dictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12)	1.1.1.100 niceE keggE
100	A7N3X1_VIBHB (A7N3X1)	1e-36	157	40%	UniProt GenBank	Putative uncharacterized protein	VIBHAR_05365	Vibrio harveyi (strain ATCC BAA-1116 / BB120)

accession

alignment

Evalue

Score

Ident.

link

information

pubmed

Q9KHK7_9ACTO
(Q9KHK7)

1e-153

545

100%

Product: Putative ketoreductase EncD
Gene: encD
Organism: Streptomyces maritimus

[pubmed all]
1uniprot Natural Metabolic Diversity Encoded by the Enterocin Biosynthesis Gene Cluster.(J. Am. Chem. Soc.) [2000]
2uniprot[Pubmed] 11137817 [Medline] 20579517 Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate 'Streptomyces maritimus': evidence for the derailment of an aromatic polyketide synthase.(Chem. Biol.) [2000]
3uniprot[Pubmed] 11948863 [Medline] 21942282 A mechanism of benzoic acid biosynthesis in plants and bacteria that mirrors fatty acid beta-oxidation.(Chembiochem) [2001]

D6MSV3_9ACTO
(D6MSV3)

3e-82

309

62%

Product: SsfU
Gene: ssfU
Organism: Streptomyces sp. SF2575

1uniprot[Pubmed] 19908837
Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.(J. Am. Chem. Soc.) [2009]

Q8VWB5_9ACTO
(Q8VWB5)

2e-79

300

59%

Product: AknA
Gene: aknA
Organism: Streptomyces galilaeus

1uniprot[Pubmed] 12399480 [Medline] 22286521
Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus.(J. Bacteriol.) [2002]

Q9L553_9ACTO
(Q9L553)

2e-78

296

59%

Product: AknA
Gene: aknA
Organism: Streptomyces galilaeus

1uniprot[Pubmed] 12137949 [Medline] 22133312
Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster.(Gene) [2002]

Q54190_9ACTO
(Q54190)

3e-78

296

59%

Product: Ketoacyl reductase
Gene: aknIII
Organism: Streptomyces galilaeus

1uniprot[Pubmed] 8157619 [Medline] 94209255
Nucleotide sequence of the aknA region of the aklavinone biosynthetic gene cluster of Streptomyces galilaeus.(J. Bacteriol.) [1994]

Q54176_STRFR
(Q54176)

1e-76

290

58%

Product: Putative ketoreductase
Gene: UrdD
Organism: Streptomyces fradiae
Streptomyces roseoflavus

1uniprot[Pubmed] 7592377 [Medline] 96042088
Cloning and characterization of a polyketide synthase from Streptomyces fradiae Tue2717 encoding the genes for biosynthesis of the angucycline antibiotic urdamycin A and a gene probably involved in its oxygenation.(J. Bacteriol.) [1995]

D2XDY2_9PSEU
(D2XDY2)

3e-76

289

59%

Product: AzicD
Gene: azicD
Organism: Kibdelosporangium sp. MJ126-NF4

1uniprot[Pubmed] 19928906
Biosynthetic studies of aziridine formation in azicemicins.(J. Am. Chem. Soc.) [2009]

Q3S8Q6_STRRM
(Q3S8Q6)

1e-75

287

60%

Product: OxyJ
Gene: oxyJ
Organism: Streptomyces rimosus

1uniprot[Pubmed] 16597959
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.(Appl. Environ. Microbiol.) [2006]

Q93LY1_9ACTO
(Q93LY1)

2e-75

287

59%

Product: Polyketide ketoreductase PgaD
Gene: pgaD
Organism: Streptomyces sp. PGA64

[pubmed all]
1uniprot[Pubmed] 12654660 [Medline] 22540650 Engineering anthracycline biosynthesis toward angucyclines.(Antimicrob. Agents Chemother.) [2003]
2uniprot[Pubmed] 15515887 Partial activation of a silent angucycline-type gene cluster from a rubromycin beta producing Streptomyces sp. PGA64.(J. Antibiot.) [2004]

C4NYK2_9ACTO
(C4NYK2)

2e-75

286

58%

Product: SaqD
Gene: saqD
Organism: Micromonospora sp. Tu 6368

[pubmed all]
1uniprot[Pubmed] 17497146 A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]
2uniprot[Pubmed] 19384899 Cloning and sequencing of the biosynthetic gene cluster for saquayamycin z and galtamycin B and the elucidation of the assembly of their saccharide chains.(Chembiochem) [2009]

Q9AMJ0_STRAT
(Q9AMJ0)

2e-75

286

58%

Product: Putative ketoreductase SimA6
Sim5
Gene: simA6
sim5
Organism: Streptomyces antibioticus

[pubmed all]
1uniprot[Pubmed] 11959542 [Medline] 21955989 Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibiotic.(Antimicrob. Agents Chemother.) [2002]
2uniprot[Pubmed] 12115055 [Medline] 22109063 Cloning and analysis of the simocyclinone biosynthetic gene cluster of Streptomyces antibioticus Tu 6040.(Arch. Microbiol.) [2002]

D7BZR7_STRBB
(D7BZR7)

1e-74

284

57%

Product: Short-chain dehydrogenase/reductase SDR
Gene: SBI_06852
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

C7QAF5_CATAD
(C7QAF5)

3e-74

283

58%

Product: Short-chain dehydrogenase/reductase SDR
Gene: Caci_3549
Organism: Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)

1uniprot
Complete genome sequence of Catenulispora acidiphila type strain (ID 139908).(Stand. Genomic Sci.) [2009]

Q47QL0_THEFY
(Q47QL0)

4e-74

282

56%

Product: Ketoacyl reductase
Gene: Tfu_1221
Organism: Thermobifida fusca (strain YX)

1uniprot[Pubmed] 17209016
Genome sequence and analysis of the soil cellulolytic actinomycete Thermobifida fusca YX.(J. Bacteriol.) [2007]

Q54812_STRPE
(Q54812)

5e-74

282

58%

Product: Daunorubicin-doxorubicin polyketide synthase
Gene: dpsE
Organism: Streptomyces peucetius

1uniprot[Pubmed] 7828855 [Medline] 95129838
Characterization of the Streptomyces peucetius ATCC 29050 genes encoding doxorubicin polyketide synthase.(Gene) [1994]

Q83X41_STRRO
(Q83X41)

6e-74

281

58%

Product: Ketoreductase
Gene: rocG
Organism: Streptomyces rochei
Streptomyces parvullus

[pubmed all]
1uniprot[Pubmed] 12791134 [Medline] 22676866 The large linear plasmid pSLA2-L of Streptomyces rochei has an unusually condensed gene organization for secondary metabolism.(Mol. Microbiol.) [2003]
2uniprot[Pubmed] 10954087 [Medline] 20408175 Cloning and analysis of the replication origin and the telomeres of the large linear plasmid pSLA2-L in Streptomyces rochei.(Mol. Gen. Genet.) [2000]
3uniprot[Pubmed] 10767533 [Medline] 20231737 Identification of two polyketide synthase gene clusters on the linear plasmid pSLA2-L in Streptomyces rochei.(Gene) [2000]
4uniprot[Pubmed] 9836424 [Medline] 99053144 Physical mapping of the linear plasmid pSLA2-L and localization of the eryAI and actI homologs.(Biosci. Biotechnol. Biochem.) [1998]

D7RFJ8_AMYOR
(D7RFJ8)

2e-73

280

57%

Product: Putative ketoreductase
Gene: bexD
Organism: Amycolatopsis orientalis subsp. vinearia

1uniprot[Pubmed] 20443562
A biosynthetic pathway for BE-7585A, a 2-thiosugar-containing angucycline-type natural product.(J. Am. Chem. Soc.) [2010]

F2RC18_STRVP
(F2RC18)

2e-73

280

56%

Product: Acetoacetyl-CoA reductase
Gene: SVEN_5983
Organism: Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)

1uniprot[Pubmed] 21463507
Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes.(BMC Genomics) [2011]

Q93LZ9_STRAU
(Q93LZ9)

3e-73

279

57%

Product: Ketoreductase-like protein
Gene: aur2E
Organism: Streptomyces aureofaciens

1uniprot[Pubmed] 15497441
Cloning and characterization of a new polyketide synthase gene cluster in Streptomyces aureofaciens CCM 3239.(DNA Seq.) [2004]

DHKR_STRCM
(P41177)

4e-73

279

57%

Product: Monensin polyketide synthase putative ketoacyl reductase
ORF5
Gene
Organism: Streptomyces cinnamonensis

1uniprot[Pubmed] 1508151 [Medline] 92374994
Characterisation of actI-homologous DNA encoding polyketide synthase genes from the monensin producer Streptomyces cinnamonensis.(Mol. Gen. Genet.) [1992]

Q56H99_STRAU
(Q56H99)

6e-73

278

57%

Product: Aur1G
Gene: aur1G
Organism: Streptomyces aureofaciens

[pubmed all]
1uniprot[Pubmed] 12384301 [Medline] 22271582 Cloning and characterization of a polyketide synthase gene cluster involved in biosynthesis of a proposed angucycline-like polyketide auricin in Streptomyces aureofaciens CCM 3239.(Gene) [2002]
2uniprot[Pubmed] 16079347 Characterization of a regulatory gene essential for the production of the angucycline-like polyketide antibiotic auricin in Streptomyces aureofaciens CCM 3239.(Microbiology) [2005]
3uniprot[Pubmed] 20466770 The role of the TetR-family transcriptional regulator Aur1R in negative regulation of the auricin gene cluster in Streptomyces aureofaciens CCM 3239.(Microbiology) [2010]

Q54491_STRNO
(Q54491)

1e-72

277

57%

Product: SnoaD
Gene: snoaD
Organism: Streptomyces nogalater

[pubmed all]
1uniprot[Pubmed] 8668120 [Medline] 96242142 A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.(Mol. Gen. Genet.) [1996]
2uniprot[Pubmed] 9349712 [Medline] 98007868 Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.(Mol. Gen. Genet.) [1997]
3uniprot[Pubmed] 8760909 [Medline] 96349102 Production of hybrid anthracycline antibiotics by heterologous expression of Streptomyces nogalater nogalamycin biosynthesis genes.(Microbiology) [1996]

D9UBK7_STRPR
(D9UBK7)

2e-72

276

58%

Product: Putative ketoreductase
Gene: c104_08c
Organism: Streptomyces pristinaespiralis

1uniprot[Pubmed] 21342465
Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011]

Q2HR23_9ACTO
(Q2HR23)

2e-72

276

57%

Product: Putative ketoreducatse
Gene: schP5
Organism: Streptomyces sp. SCC 2136

1uniprot
Angucyclines Sch 47554 and Sch 47555 from Streptomyces sp. SCC-2136: Cloning, Sequencing, and Characterization.(Mol. Cells) [2006]

2uniprot
Molecular cloning and characterization of biosynthetic genes cluster of Sch 47554 from Streptomyces sp. SCC 2136. [2004]

Q54280_SACHI
(Q54280)

5e-72

275

56%

Product: Polyketide reductase
Gene
Organism: Saccharopolyspora hirsuta

1uniprot[Pubmed] 8341260 [Medline] 93341453
Saccharopolyspora hirsuta 367 encodes clustered genes similar to ketoacyl synthase, ketoacyl reductase, acyl carrier protein, and biotin carboxyl carrier protein.(Mol. Gen. Genet.) [1993]

Q55221_STRSQ
(Q55221)

8e-72

274

57%

Product: Polyketide reductase
Gene: dauB
Organism: Streptomyces sp

1uniprot[Pubmed] 7928998 [Medline] 95014072
Isolation and sequence analysis of polyketide synthase genes from the daunomycin-producing Streptomyces sp. strain C5.(J. Bacteriol.) [1994]

Q56166_9ACTO
(Q56166)

2e-71

273

55%

Product: Ketoreductase
Gene
Organism: Streptomyces venezuelae

1uniprot[Pubmed] 7881555 [Medline] 95187308
Cloning and characterization of polyketide synthase genes for jadomycin B biosynthesis in Streptomyces venezuelae ISP5230.(Microbiology) [1994]

2uniprot
Functional characterization of the jadI gene as a cyclase forming angucyclinones.(J. Am. Chem. Soc.) [1999]

D5MRI8_9ACTO
(D5MRI8)

2e-71

273

58%

Product: Putative ketoreductase
Gene: hrbO
Organism: Streptomyces sp. 2238-SVT4

1uniprot[Pubmed] 20453135
Cloning and characterization of a gene cluster for hatomarubigin biosynthesis in Streptomyces sp. strain 2238-SVT4.(Appl. Environ. Microbiol.) [2010]

Q54220_STRGR
(Q54220)

1e-70

271

56%

Product: Ketoreductase
Gene
Organism: Streptomyces griseus

1uniprot[Pubmed] 8169211 [Medline] 94222841
Cloning, sequencing, and analysis of the griseusin polyketide synthase gene cluster from Streptomyces griseus.(J. Bacteriol.) [1994]

D1A6T4_THECD
(D1A6T4)

1e-70

270

57%

Product: Short-chain dehydrogenase/reductase SDR
Gene: Tcur_2793
Organism: Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)

1uniprot
Complete genome sequence of Thermomonospora curvata type strain (B9).(Stand. Genomic Sci.) [2011]

Q2J5J1_FRASC
(Q2J5J1)

3e-70

269

58%

Product: Short-chain dehydrogenase/reductase SDR
Gene: Francci3_4103
Organism: Frankia sp. (strain CcI3)

1uniprot[Pubmed] 17151343
Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007]

ACT3_STRCO
(P16544)

4e-70

269

53%

Product: Putative ketoacyl reductase
Gene: actIII
SCO5086
SCBAC28G1.12c
Organism: Streptomyces coelicolor

[pubmed all]
1uniprot[Pubmed] 2469622 [Medline] 89232723 Nucleotide sequence, transcription and deduced function of a gene involved in polyketide antibiotic synthesis in Streptomyces coelicolor.(Gene) [1988]
2uniprot[Pubmed] 12000953 [Medline] 21996410 Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).(Nature) [2002]
3uniprot[Pubmed] 15544323 Structural analysis of actinorhodin polyketide ketoreductase: cofactor binding and substrate specificity.(Biochemistry) [2004]
4uniprot[Pubmed] 15458634 The crystal structure of the actIII actinorhodin polyketide reductase: proposed mechanism for ACP and polyketide binding.(Structure) [2004]

Q6VMJ0_STRAM
(Q6VMJ0)

8e-70

268

55%

Product: Polyketide ketoreductase
Putative polyketide ketoreductase
Gene: alpD
DSMT0182
Organism: Streptomyces ambofaciens

[pubmed all]
1uniprot[Pubmed] 14742212 Functional angucycline-like antibiotic gene cluster in the terminal inverted repeats of the Streptomyces ambofaciens linear chromosome.(Antimicrob. Agents Chemother.) [2004]
2uniprot[Pubmed] 16952952 Intraspecific variability of the terminal inverted repeats of the linear chromosome of Streptomyces ambofaciens.(J. Bacteriol.) [2006]

Q1RQS3_STRAM
(Q1RQS3)

8e-70

268

55%

Product: Polyketide ketoreductase
Gene: alpD
SAMT0162
SAMT0163
Organism: Streptomyces ambofaciens ATCC 23877

[pubmed all]
1uniprot[Pubmed] 16952952 Intraspecific variability of the terminal inverted repeats of the linear chromosome of Streptomyces ambofaciens.(J. Bacteriol.) [2006]
2uniprot[Pubmed] 16956972 Evolution of the terminal regions of the Streptomyces linear chromosome.(Mol. Biol. Evol.) [2006]
3uniprot Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877.(Microbiology (Mosc.)) [2006]

Q67G28_9ACTO
(Q67G28)

3e-69

266

56%

Product: Keto reductase
Gene
Organism: Streptomyces griseoruber

1uniprot[Pubmed] 15271354
The hedamycin locus implicates a novel aromatic PKS priming mechanism.(Chem. Biol.) [2004]

Q4R0M6_STRCX
(Q4R0M6)

3e-69

266

57%

Product: ChaD protein
Gene: chaD
Organism: Streptomyces chartreusis

1uniprot[Pubmed] 15911378
Biosynthesis of the antitumor agent chartreusin involves the oxidative rearrangement of an anthracyclic polyketide.(Chem. Biol.) [2005]

Q9ZGD4_STRCY
(Q9ZGD4)

3e-69

266

58%

Product: Reductase homolog
Gene: lanD
Organism: Streptomyces cyanogenus

1uniprot[Pubmed] 9933932 [Medline] 99132695
Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin biosynthesis.(FEMS Microbiol. Lett.) [1999]

Q9FCM4_STRAT
(Q9FCM4)

4e-69

265

54%

Product: Putative keto reductase
Gene
Organism: Streptomyces antibioticus

1uniprot[Pubmed] 11700358 [Medline] 21557167
A polyketide biosynthetic gene cluster from Streptomyces antibioticus includes a LysR-type transcriptional regulator.(Microbiology) [2001]

D9UBR2_STRPR
(D9UBR2)

9e-69

264

54%

Product: Putative ketoreductase
Gene: cpp22
Organism: Streptomyces pristinaespiralis

1uniprot[Pubmed] 21342465
Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011]

Q7WT12_9ACTO
(Q7WT12)

1e-68

264

55%

Product: Keto reductase (KR)
Gene: med-ORF6
Organism: Streptomyces sp. AM-7161

1uniprot
Cloning, sequencing and heterologous expression of the medermycin biosynthetic gene cluster of Streptomyces sp. AM-7161: towards comparative analysis of the benzoisochromanequione gene clusters.(Microbiology (Mosc.)) [2003]

B6SEF4_9ACTO
(B6SEF4)

2e-68

263

58%

Product: AlnP ketoreductase
Gene: alnP
Organism: Streptomyces sp. CM020

1uniprot[Pubmed] 18940666
Characterization of the alnumycin gene cluster reveals unusual gene products for pyran ring formation and dioxan biosynthesis.(Chem. Biol.) [2008]

Q7X2G2_9ACTO
(Q7X2G2)

3e-68

262

55%

Product: Putative ketoreductase
Gene: gilF
Organism: Streptomyces griseoflavus

1uniprot[Pubmed] 12822997 [Medline] 22708304
The complete gene cluster of the antitumor agent gilvocarcin V and its implication for the biosynthesis of the gilvocarcins.(J. Am. Chem. Soc.) [2003]

Q54998_9ACTO
(Q54998)

1e-65

254

59%

Product: Ketoreductase
Gene: frnP
Organism: Streptomyces roseofulvus

1uniprot[Pubmed] 8181754 [Medline] 94237486
Cloning, sequencing and deduced functions of a cluster of Streptomyces genes probably encoding biosynthesis of the polyketide antibiotic frenolicin.(Gene) [1994]

DHK1_STRVN
(P16542)

5e-65

252

55%

Product: Granaticin polyketide synthase putative ketoacyl reductase 1
ORF5
Gene: gra-orf5
Organism: Streptomyces violaceoruber

[pubmed all]
1uniprot[Pubmed] 2583128 [Medline] 90060034 Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber Tu22.(EMBO J.) [1989]
2uniprot[Pubmed] 7476861 [Medline] 96027933 Identification of Streptomyces violaceoruber Tu22 genes involved in the biosynthesis of granaticin.(Mol. Gen. Genet.) [1995]
3uniprot[Pubmed] 9831526 [Medline] 99051446 The granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tu22: sequence analysis and expression in a heterologous host.(Chem. Biol.) [1998]

Q4R0K8_STRCX
(Q4R0K8)

6e-63

245

52%

Product: ChaZ protein
Gene: chaZ
Organism: Streptomyces chartreusis

1uniprot[Pubmed] 15911378
Biosynthesis of the antitumor agent chartreusin involves the oxidative rearrangement of an anthracyclic polyketide.(Chem. Biol.) [2005]

C7PWR3_CATAD
(C7PWR3)

4e-62

242

54%

Product: Short-chain dehydrogenase/reductase SDR
Gene: Caci_6493
Organism: Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)

1uniprot
Complete genome sequence of Catenulispora acidiphila type strain (ID 139908).(Stand. Genomic Sci.) [2009]

Q7MZT0_PHOLL
(Q7MZT0)

1e-56

224

47%

Product: Similar to polyketide ketoreductase
Gene: plu4194
Organism: Photorhabdus luminescens subsp. laumondii (strain TT01)

1uniprot[Pubmed] 14528314 [Medline] 22957627
The genome sequence of the entomopathogenic bacterium Photorhabdus luminescens.(Nat. Biotechnol.) [2003]

Q53484_STRMY
(Q53484)

2e-56

223

48%

Product: Polyketide ketoreductase
Gene: MPKR
Organism: Streptomyces mycarofaciens

1uniprot[Pubmed] 7893937 [Medline] 95201158
Characterization of polyketide ketoreductase gene (MPKR) from midecamycin-producing strain (Streptomyces mycarofaciens 1748).(Chin. J. Biotechnol.) [1994]

Q2J5E8_FRASC
(Q2J5E8)

2e-43

181

53%

Product: Short-chain dehydrogenase/reductase SDR
Gene: Francci3_4146
Organism: Frankia sp. (strain CcI3)

1uniprot[Pubmed] 17151343
Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007]

Q481D0_COLP3
(Q481D0)

2e-40

170

42%

Product: Acetoacetyl-CoA reductase
Gene: phbB1
CPS_2625
Organism: Colwellia psychrerythraea (strain 34H / ATCC BAA-681)
Vibrio psychroerythus

1uniprot[Pubmed] 16043709
The psychrophilic lifestyle as revealed by the genome sequence of Colwellia psychrerythraea 34H through genomic and proteomic analyses.(Proc. Natl. Acad. Sci. U.S.A.) [2005]

Q7MD25_VIBVY
(Q7MD25)

6e-39

165

41%

Product: Dehydrogenase
Gene: VVA1211
Organism: Vibrio vulnificus (strain YJ016)

1uniprot[Pubmed] 14656965
Comparative genome analysis of Vibrio vulnificus, a marine pathogen.(Genome Res.) [2003]

Q8DIS9_THEEB
(Q8DIS9)

1e-38

164

43%

Product: 3-oxoacyl-[acyl-carrier-protein] reductase
Gene: tlr1502
Organism: Thermosynechococcus elongatus (strain BP-1)

1uniprot[Pubmed] 12240834 [Medline] 22225144
Complete genome structure of the thermophilic cyanobacterium Thermosynechococcus elongatus BP-1.(DNA Res.) [2002]

E8VVC2_VIBVU
(E8VVC2)

6e-38

162

40%

Product: Acetoacetyl-CoA reductase
Gene: VVMO6_04115
Organism: Vibrio vulnificus MO6-24/O

1uniprot[Pubmed] 21317338
Complete Genome Sequence of Vibrio vulnificus MO6-24/O.(J. Bacteriol.) [2011]

D4TKB0_9NOST
(D4TKB0)

1e-37

160

42%

Product: 3-oxoacyl-(Acyl-carrier-protein) reductase
Gene: fabG
CRC_02805
Organism: Cylindrospermopsis raciborskii CS-505

1uniprot[Pubmed] 20169071
The smallest known genomes of multicellular and toxic cyanobacteria: comparison, minimal gene sets for linked traits and the evolutionary implications.(PLoS ONE) [2010]

D2RL00_ACIFV
(D2RL00)

2e-37

160

41%

Product: 3-oxoacyl-(Acyl-carrier-protein) reductase
Gene: Acfer_1392
Organism: Acidaminococcus fermentans (strain ATCC 25085 / DSM 20731 / VR4)

1uniprot
Complete genome sequence of Acidaminococcus fermentans type strain (VR4).(Stand. Genomic Sci.) [2010]

B0JMC7_MICAN
(B0JMC7)

2e-37

160

40%

Product: 3-oxoacyl-[acyl-carrier protein] reductase
Gene: MAE_33900
Organism: Microcystis aeruginosa (strain NIES-843)

1uniprot[Pubmed] 18192279
Complete genomic structure of the bloom-forming toxic cyanobacterium Microcystis aeruginosa NIES-843.(DNA Res.) [2007]

D4TRN7_9NOST
(D4TRN7)

4e-37

159

41%

Product: 3-oxoacyl-(Acyl-carrier-like protein) reductase
Gene: fabG
CRD_02288
Organism: Raphidiopsis brookii D9

1uniprot[Pubmed] 20169071
The smallest known genomes of multicellular and toxic cyanobacteria: comparison, minimal gene sets for linked traits and the evolutionary implications.(PLoS ONE) [2010]

A2C0R0_PROM1
(A2C0R0)

7e-37

158

39%

Product: 3-oxoacyl-[acyl-carrier protein] reductase
Gene: NATL1_05081
Organism: Prochlorococcus marinus (strain NATL1A)

1uniprot[Pubmed] 18159947
Patterns and implications of gene gain and loss in the evolution of Prochlorococcus.(PLoS Genet.) [2007]

Q6LKI6_PHOPR
(Q6LKI6)

1e-36

157

42%

Product: Putative acetoacetyl-CoA reductase
Gene: XCC2294
PBPRB0350
Organism: Photobacterium profundum
Photobacterium sp. (strain SS9)

1uniprot[Pubmed] 15746425
Life at depth: Photobacterium profundum genome sequence and expression analysis.(Science) [2005]