| accession | DB | alignment | Evalue | Score | Ident. | link | information | pubmed |
1
|
ACPX_STRVN (P12885) |
|
|
2e-38 |
162 |
100% |
|
- Product
- Granaticin polyketide synthase acyl carrier protein
- Gene
- gra-orf3
- Organism
- Streptomyces violaceoruber
|
1uniprot[Pubmed] 2583128 [Medline] 90060034 Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber Tu22.(EMBO J.) [1989] | 2uniprot[Pubmed] 9831526 [Medline] 99051446 The granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tu22: sequence analysis and expression in a heterologous host.(Chem. Biol.) [1998] | 3uniprot[Pubmed] 7476861 [Medline] 96027933 Identification of Streptomyces violaceoruber Tu22 genes involved in the biosynthesis of granaticin.(Mol. Gen. Genet.) [1995] | [pubmed all]
|
4
|
Q9X463_STRAE (Q9X463) |
|
|
4e-22 |
108 |
71% |
|
- Product
- Acyl carrier protein
- Gene
- ncnC
- Organism
- Streptomyces arenae
|
1uniprot[Pubmed] 10206788 [Medline] 99217421 Isolation and characterization of the naphthocyclinone gene cluster from Streptomyces arenae DSM 40737 and heterologous expression of the polyketide synthase genes.(Gene) [1999] |
|
5
|
Q9FCM6_STRAT (Q9FCM6) |
|
|
9e-22 |
107 |
66% |
|
- Product
- Putative Acyl carrier protein
- Gene
-
- Organism
- Streptomyces antibioticus
|
1uniprot[Pubmed] 11700358 [Medline] 21557167 A polyketide biosynthetic gene cluster from Streptomyces antibioticus includes a LysR-type transcriptional regulator.(Microbiology) [2001] |
|
7
|
Q54283_SACHI (Q54283) |
|
|
7e-19 |
97.4 |
59% |
|
- Product
- Acyl carrier protein
- Gene
-
- Organism
- Saccharopolyspora hirsuta
|
1uniprot[Pubmed] 8341260 [Medline] 93341453 Saccharopolyspora hirsuta 367 encodes clustered genes similar to ketoacyl synthase, ketoacyl reductase, acyl carrier protein, and biotin carboxyl carrier protein.(Mol. Gen. Genet.) [1993] |
|
9
|
ACPX_STRCO (Q02054) |
|
|
4e-18 |
94.7 |
62% |
|
- Product
- Actinorhodin polyketide synthase acyl carrier protein
actI ORF3
- Gene
- SCO5089
SCBAC28G1.15
- Organism
- Streptomyces coelicolor
|
1uniprot[Pubmed] 1527048 [Medline] 92406871 Nucleotide sequence and deduced functions of a set of cotranscribed genes of Streptomyces coelicolor A3(2) including the polyketide synthase for the antibiotic actinorhodin.(J. Biol. Chem.) [1992] | 2uniprot[Pubmed] 12000953 [Medline] 21996410 Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).(Nature) [2002] | 3uniprot[Pubmed] 9166770 [Medline] 97309355 Solution structure of the actinorhodin polyketide synthase acyl carrier protein from Streptomyces coelicolor A3(2).(Biochemistry) [1997] | [pubmed all]
|
10
|
Q9F6C8_9ACTO (Q9F6C8) |
|
|
1e-16 |
90.1 |
63% |
|
- Product
- Acyl carrier protein
- Gene
- zhuN
- Organism
- Streptomyces sp. R1128
|
1uniprot[Pubmed] 10931852 [Medline] 20517899 Cloning, nucleotide sequence, and heterologous expression of the biosynthetic gene cluster for R1128, a non-steroidal estrogen receptor antagonist. Insights into an unusual priming mechanism.(J. Biol. Chem.) [2000] |
|
11
|
D2XDY1_9PSEU (D2XDY1) |
|
|
1e-16 |
90.1 |
55% |
|
- Product
- AzicC
- Gene
- azicC
- Organism
- Kibdelosporangium sp. MJ126-NF4
|
1uniprot[Pubmed] 19928906 Biosynthetic studies of aziridine formation in azicemicins.(J. Am. Chem. Soc.) [2009] |
|
12
|
D7BZR1_STRBB (D7BZR1) |
|
|
1e-16 |
89.7 |
55% |
|
- Product
- Phosphopantetheine-binding protein
- Gene
- SBI_06846
- Organism
- Streptomyces bingchenggensis (strain BCW-1)
|
1uniprot[Pubmed] 20581206 Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010] |
|
13
|
D9UBR7_STRPR (D9UBR7) |
|
|
3e-16 |
88.6 |
64% |
|
- Product
- Putative acyl carrier protein
- Gene
- cpp17
- Organism
- Streptomyces pristinaespiralis
|
1uniprot[Pubmed] 21342465 Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011] |
|
17
|
Q4R0M0_STRCX (Q4R0M0) |
|
|
5e-15 |
84.3 |
53% |
|
- Product
- ChaC protein
- Gene
- chaC
- Organism
- Streptomyces chartreusis
|
1uniprot[Pubmed] 15911378 Biosynthesis of the antitumor agent chartreusin involves the oxidative rearrangement of an anthracyclic polyketide.(Chem. Biol.) [2005] |
|
20
|
Q93LY2_9ACTO (Q93LY2) |
|
|
2e-14 |
82.8 |
53% |
|
- Product
- Acyl carrier protein PgaC
- Gene
- pgaC
- Organism
- Streptomyces sp. PGA64
|
1uniprot[Pubmed] 12654660 [Medline] 22540650 Engineering anthracycline biosynthesis toward angucyclines.(Antimicrob. Agents Chemother.) [2003] | 2uniprot[Pubmed] 15515887 Partial activation of a silent angucycline-type gene cluster from a rubromycin beta producing Streptomyces sp. PGA64.(J. Antibiot.) [2004] | [pubmed all]
|
21
|
C4NYK1_9ACTO (C4NYK1) |
|
|
2e-14 |
82.8 |
57% |
|
- Product
- SaqC
- Gene
- saqC
- Organism
- Micromonospora sp. Tu 6368
|
1uniprot[Pubmed] 17497146 A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007] | 2uniprot[Pubmed] 19384899 Cloning and sequencing of the biosynthetic gene cluster for saquayamycin z and galtamycin B and the elucidation of the assembly of their saccharide chains.(Chembiochem) [2009] | [pubmed all]
|
22
|
Q0MRN3_9ACTO (Q0MRN3) |
|
|
2e-14 |
82.8 |
52% |
|
- Product
- Putative acyl carrier protein
- Gene
-
- Organism
- Streptomyces toxytricini
|
1uniprot[Pubmed] 17205043 Cloning and analysis of a type II polyketide synthase gene cluster from Streptomyces toxytricini NRRL 15,443.(J. Microbiol.) [2006] |
|
23
|
F4FBT5_VERMA (F4FBT5) |
|
|
7e-14 |
80.9 |
52% |
|
- Product
- Putative uncharacterized protein
- Gene
- VAB18032_18165
- Organism
- Verrucosispora maris (strain AB-18-032)
|
1uniprot[Pubmed] 21551311 Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.(J. Bacteriol.) [2011] |
|
24
|
Q9AMJ1_STRAT (Q9AMJ1) |
|
|
9e-14 |
80.5 |
55% |
|
- Product
- Putative acyl carrier protein SimA3
Sim4
- Gene
- simA3
sim4
- Organism
- Streptomyces antibioticus
|
1uniprot[Pubmed] 11959542 [Medline] 21955989 Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibiotic.(Antimicrob. Agents Chemother.) [2002] | 2uniprot[Pubmed] 12115055 [Medline] 22109063 Cloning and analysis of the simocyclinone biosynthetic gene cluster of Streptomyces antibioticus Tu 6040.(Arch. Microbiol.) [2002] | [pubmed all]
|
26
|
Q54219_STRGR (Q54219) |
|
|
2e-13 |
79.3 |
55% |
|
- Product
- Acyl carrier protein
- Gene
-
- Organism
- Streptomyces griseus
|
1uniprot[Pubmed] 8169211 [Medline] 94222841 Cloning, sequencing, and analysis of the griseusin polyketide synthase gene cluster from Streptomyces griseus.(J. Bacteriol.) [1994] |
|
27
|
F2RC17_STRVP (F2RC17) |
|
|
2e-13 |
79 |
55% |
|
- Product
- Acyl carrier protein
- Gene
- SVEN_5982
- Organism
- Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
|
1uniprot[Pubmed] 21463507 Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes.(BMC Genomics) [2011] |
|
28
|
Q56165_9ACTO (Q56165) |
|
|
2e-13 |
79 |
55% |
|
- Product
- Acyl carrier protein
- Gene
- acp
- Organism
- Streptomyces venezuelae
|
1uniprot[Pubmed] 7881555 [Medline] 95187308 Cloning and characterization of polyketide synthase genes for jadomycin B biosynthesis in Streptomyces venezuelae ISP5230.(Microbiology) [1994] | 2uniprot Functional characterization of the jadI gene as a cyclase forming angucyclinones.(J. Am. Chem. Soc.) [1999] |
|
30
|
Q7WT30_9ACTO (Q7WT30) |
|
|
3e-13 |
79 |
55% |
|
- Product
- Acyl carrier protein (ACP)
- Gene
- med-ORF23
- Organism
- Streptomyces sp. AM-7161
|
1uniprot Cloning, sequencing and heterologous expression of the medermycin biosynthetic gene cluster of Streptomyces sp. AM-7161: towards comparative analysis of the benzoisochromanequione gene clusters.(Microbiology (Mosc.)) [2003] |
|
31
|
D5MRI6_9ACTO (D5MRI6) |
|
|
3e-13 |
78.6 |
55% |
|
- Product
- Putative acyl carrier protein
- Gene
- hrbM
- Organism
- Streptomyces sp. 2238-SVT4
|
1uniprot[Pubmed] 20453135 Cloning and characterization of a gene cluster for hatomarubigin biosynthesis in Streptomyces sp. strain 2238-SVT4.(Appl. Environ. Microbiol.) [2010] |
|
32
|
D6MSY3_9ACTO (D6MSY3) |
|
|
3e-13 |
78.6 |
51% |
|
- Product
- SsfC
- Gene
- ssfC
- Organism
- Streptomyces sp. SF2575
|
1uniprot[Pubmed] 19908837 Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.(J. Am. Chem. Soc.) [2009] |
|
34
|
Q2HR22_9ACTO (Q2HR22) |
|
|
3e-13 |
78.6 |
55% |
|
- Product
- Putative acyl carrier protein
- Gene
- schP6
- Organism
- Streptomyces sp. SCC 2136
|
1uniprot Angucyclines Sch 47554 and Sch 47555 from Streptomyces sp. SCC-2136: Cloning, Sequencing, and Characterization.(Mol. Cells) [2006] | 2uniprot Molecular cloning and characterization of biosynthetic genes cluster of Sch 47554 from Streptomyces sp. SCC 2136. [2004] |
|
36
|
Q54175_STRFR (Q54175) |
|
|
1e-12 |
76.6 |
52% |
|
- Product
- Putative acyl carrier protein
- Gene
- UrdC
- Organism
- Streptomyces fradiae
Streptomyces roseoflavus
|
1uniprot[Pubmed] 7592377 [Medline] 96042088 Cloning and characterization of a polyketide synthase from Streptomyces fradiae Tue2717 encoding the genes for biosynthesis of the angucycline antibiotic urdamycin A and a gene probably involved in its oxygenation.(J. Bacteriol.) [1995] |
|
37
|
D2AY46_STRRD (D2AY46) |
|
|
1e-12 |
76.6 |
53% |
|
- Product
- Putative uncharacterized protein
- Gene
- Sros_4152
- Organism
- Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
|
1uniprot Complete genome sequence of Streptosporangium roseum type strain (NI 9100T).(Stand. Genomic Sci.) [2010] |
|
38
|
Q56HA0_STRAU (Q56HA0) |
|
|
2e-12 |
76.3 |
52% |
|
- Product
- Aur1F
- Gene
- aur1F
- Organism
- Streptomyces aureofaciens
|
1uniprot[Pubmed] 12384301 [Medline] 22271582 Cloning and characterization of a polyketide synthase gene cluster involved in biosynthesis of a proposed angucycline-like polyketide auricin in Streptomyces aureofaciens CCM 3239.(Gene) [2002] | 2uniprot[Pubmed] 16079347 Characterization of a regulatory gene essential for the production of the angucycline-like polyketide antibiotic auricin in Streptomyces aureofaciens CCM 3239.(Microbiology) [2005] | 3uniprot[Pubmed] 20466770 The role of the TetR-family transcriptional regulator Aur1R in negative regulation of the auricin gene cluster in Streptomyces aureofaciens CCM 3239.(Microbiology) [2010] | [pubmed all]
|
40
|
Q47QL1_THEFY (Q47QL1) |
|
|
2e-12 |
76.3 |
53% |
|
- Product
- Actinorhodin polyketide synthase acyl carrier protein / 3-oxoacyl-ACP synthase acyl carrier protein
- Gene
- Tfu_1220
- Organism
- Thermobifida fusca (strain YX)
|
1uniprot[Pubmed] 17209016 Genome sequence and analysis of the soil cellulolytic actinomycete Thermobifida fusca YX.(J. Bacteriol.) [2007] |
|
41
|
D9UBS9_STRPR (D9UBS9) |
|
|
2e-12 |
76.3 |
51% |
|
- Product
- Putative acyl carrier protein
- Gene
- cpp5
- Organism
- Streptomyces pristinaespiralis
|
1uniprot[Pubmed] 21342465 Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011] |
|
43
|
Q2J5E7_FRASC (Q2J5E7) |
|
|
2e-12 |
75.9 |
55% |
|
- Product
- Phosphopantetheine-binding
- Gene
- Francci3_4147
- Organism
- Frankia sp. (strain CcI3)
|
1uniprot[Pubmed] 17151343 Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007] |
|
44
|
C7PWQ7_CATAD (C7PWQ7) |
|
|
2e-12 |
75.5 |
53% |
|
- Product
- Phosphopantetheine-binding
- Gene
- Caci_6487
- Organism
- Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
|
1uniprot Complete genome sequence of Catenulispora acidiphila type strain (ID 139908).(Stand. Genomic Sci.) [2009] |
|
45
|
E2D2I6_9BACT (E2D2I6) |
|
|
3e-12 |
75.5 |
52% |
|
- Product
- Acyl carrier protein
- Gene
-
- Organism
- uncultured soil bacterium
|
1uniprot[Pubmed] 20577994 Cloning large natural product gene clusters from the environment: piecing environmental DNA gene clusters back together with TAR.(Biopolymers) [2010] |
|
46
|
Q9ZGD5_STRCY (Q9ZGD5) |
|
|
3e-12 |
75.5 |
53% |
|
- Product
- Acyl carrier protein homolog
- Gene
- lanC
- Organism
- Streptomyces cyanogenus
|
1uniprot[Pubmed] 9933932 [Medline] 99132695 Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin biosynthesis.(FEMS Microbiol. Lett.) [1999] |
|
49
|
Q9XDZ8_9ACTO (Q9XDZ8) |
|
|
6e-12 |
74.3 |
49% |
|
- Product
- Polyketide synthase
- Gene
-
- Organism
- Actinomadura verrucosospora
|
1uniprot[Pubmed] 10347064 [Medline] 99278093 Development of a self-cloning system for Actinomadura verrucosospora and identification of polyketide synthase genes essential for production of the angucyclic antibiotic pradimicin.(Appl. Environ. Microbiol.) [1999] |
|
51
|
B6SEF3_9ACTO (B6SEF3) |
|
|
7e-12 |
73.9 |
49% |
|
- Product
- AlnN acyl carrier protein
- Gene
- alnN
- Organism
- Streptomyces sp. CM020
|
1uniprot[Pubmed] 18940666 Characterization of the alnumycin gene cluster reveals unusual gene products for pyran ring formation and dioxan biosynthesis.(Chem. Biol.) [2008] |
|
52
|
Q54996_9ACTO (Q54996) |
|
|
9e-12 |
73.9 |
50% |
|
- Product
- Acyl carrier protein
- Gene
- frnN
- Organism
- Streptomyces roseofulvus
|
1uniprot[Pubmed] 8181754 [Medline] 94237486 Cloning, sequencing and deduced functions of a cluster of Streptomyces genes probably encoding biosynthesis of the polyketide antibiotic frenolicin.(Gene) [1994] | 2uniprot[Pubmed] 12705828 [Medline] 22592266 Solution structure and backbone dynamics of the holo form of the frenolicin acyl carrier protein.(Biochemistry) [2003] | [pubmed all]
|
53
|
Q6VMI9_STRAM (Q6VMI9) |
|
|
1e-11 |
73.6 |
50% |
|
- Product
- Putative acyl carrier protein
- Gene
- alpC
DSMT0183
- Organism
- Streptomyces ambofaciens
|
1uniprot[Pubmed] 14742212 Functional angucycline-like antibiotic gene cluster in the terminal inverted repeats of the Streptomyces ambofaciens linear chromosome.(Antimicrob. Agents Chemother.) [2004] | 2uniprot[Pubmed] 16952952 Intraspecific variability of the terminal inverted repeats of the linear chromosome of Streptomyces ambofaciens.(J. Bacteriol.) [2006] | [pubmed all]
|
54
|
Q1RQS2_STRAM (Q1RQS2) |
|
|
1e-11 |
73.6 |
50% |
|
- Product
- Putative acyl carrier protein
- Gene
- alpC
SAMT0163 SAMT0164
- Organism
- Streptomyces ambofaciens ATCC 23877
|
1uniprot[Pubmed] 16952952 Intraspecific variability of the terminal inverted repeats of the linear chromosome of Streptomyces ambofaciens.(J. Bacteriol.) [2006] | 2uniprot[Pubmed] 16956972 Evolution of the terminal regions of the Streptomyces linear chromosome.(Mol. Biol. Evol.) [2006] | 3uniprot Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877.(Microbiology (Mosc.)) [2006] | [pubmed all]
|
55
|
A8KQY0_9ACTO (A8KQY0) |
|
|
1e-11 |
73.2 |
48% |
|
- Product
- Acyl carrier protein
- Gene
- elmM
- Organism
- Streptomyces olivaceus
|
1uniprot[Pubmed] 18310024 Biosynthesis of elloramycin in Streptomyces olivaceus requires glycosylation by enzymes encoded outside the aglycon cluster.(Microbiology) [2008] |
|
57
|
Q48377_KIBAR (Q48377) |
|
|
2e-11 |
72.8 |
48% |
|
- Product
- ArdIorf3
- Gene
- ardIorf3
- Organism
- Kibdelosporangium aridum
|
1uniprot[Pubmed] 7987007 [Medline] 95078455 Cloning and nucleotide sequence of a region of the Kibdelosporangium aridum genome homologous to polyketide biosynthetic genes.(DNA Seq.) [1994] |
|
59
|
D1A6T5_THECD (D1A6T5) |
|
|
2e-11 |
72.8 |
54% |
|
- Product
- Phosphopantetheine-binding protein
- Gene
- Tcur_2794
- Organism
- Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
|
1uniprot Complete genome sequence of Thermomonospora curvata type strain (B9).(Stand. Genomic Sci.) [2011] |
|
61
|
Q67G32_9ACTO (Q67G32) |
|
|
2e-11 |
72.4 |
48% |
|
- Product
- Putative bifunctional cyclase dehydratase and ACP fusion
- Gene
-
- Organism
- Streptomyces griseoruber
|
1uniprot[Pubmed] 15271354 The hedamycin locus implicates a novel aromatic PKS priming mechanism.(Chem. Biol.) [2004] |
|
62
|
Q8VWB1_9ACTO (Q8VWB1) |
|
|
3e-11 |
72 |
47% |
|
- Product
- AknD
- Gene
- aknD
- Organism
- Streptomyces galilaeus
|
1uniprot[Pubmed] 12399480 [Medline] 22286521 Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus.(J. Bacteriol.) [2002] |
|
63
|
D2SZ01_MICEC (D2SZ01) |
|
|
3e-11 |
72 |
48% |
|
- Product
- Acyl carrier protein
- Gene
-
- Organism
- Micromonospora echinospora subsp. challisensis
|
1uniprot[Pubmed] 19680283 TLN-05220, TLN-05223, new Echinosporamicin-type antibiotics, and proposed revision of the structure of bravomicins(*).(J. Antibiot.) [2009] |
|
64
|
Q3S8R2_STRRM (Q3S8R2) |
|
|
5e-11 |
71.2 |
49% |
|
- Product
- OxyC
- Gene
- oxyC
- Organism
- Streptomyces rimosus
|
1uniprot[Pubmed] 16597959 Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.(Appl. Environ. Microbiol.) [2006] |
|
65
|
ACPX_STRRM (P43677) |
|
|
5e-11 |
71.2 |
49% |
|
- Product
- Oxytetracycline polyketide synthase acyl carrier protein
- Gene
-
- Organism
- Streptomyces rimosus
|
1uniprot[Pubmed] 8163168 [Medline] 94215879 Sequences of the oxytetracycline polyketide synthase-encoding otc genes from Streptomyces rimosus.(Gene) [1994] |
|
67
|
C7QAF4_CATAD (C7QAF4) |
|
|
1e-10 |
70.1 |
49% |
|
- Product
- Phosphopantetheine-binding
- Gene
- Caci_3548
- Organism
- Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
|
1uniprot Complete genome sequence of Catenulispora acidiphila type strain (ID 139908).(Stand. Genomic Sci.) [2009] |
|
68
|
Q9L549_9ACTO (Q9L549) |
|
|
2e-10 |
69.3 |
46% |
|
- Product
- AknD
- Gene
- aknD
- Organism
- Streptomyces galilaeus
|
1uniprot[Pubmed] 12137949 [Medline] 22133312 Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster.(Gene) [2002] |
|
69
|
ACPX_STRGA (P12884) |
|
|
3e-10 |
68.9 |
47% |
|
- Product
- Tetracenomycin C polyketide synthase acyl carrier protein
- Gene
- tcmM
- Organism
- Streptomyces glaucescens
|
1uniprot[Pubmed] 2684656 [Medline] 90060035 Analysis of the nucleotide sequence of the Streptomyces glaucescens tcmI genes provides key information about the enzymology of polyketide antibiotic biosynthesis.(EMBO J.) [1989] | 2uniprot[Pubmed] 1548230 [Medline] 92193265 Nucleotide sequence of the tcmII-tcmIV region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens and evidence that the tcmN gene encodes a multifunctional cyclase-dehydratase-O-methyl transferase.(J. Bacteriol.) [1992] | [pubmed all]
|
70
|
Q93H99_STRAW (Q93H99) |
|
|
4e-10 |
68.2 |
47% |
|
- Product
- Acyl carrier protein
Putative acyl carrier protein
- Gene
- pks9-1
SAV2373 SAV_2373
- Organism
- Streptomyces avermitilis
|
1uniprot[Pubmed] 11572948 [Medline] 21477403 Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.(Proc. Natl. Acad. Sci. U.S.A.) [2001] | 2uniprot[Pubmed] 12692562 [Medline] 22608306 Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis.(Nat. Biotechnol.) [2003] | [pubmed all]
|
72
|
Q2PA09_9ACTO (Q2PA09) |
|
|
5e-10 |
68.2 |
57% |
|
- Product
- Acyl carrier protein
- Gene
- stfS
- Organism
- Streptomyces steffisburgensis
|
1uniprot[Pubmed] 16751529 Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin.(Appl. Environ. Microbiol.) [2006] |
|
73
|
D3U9Z5_9ACTO (D3U9Z5) |
|
|
6e-10 |
67.8 |
46% |
|
- Product
- Acyl carrier protein
- Gene
- sfaO
- Organism
- Streptomyces flaveolus
|
1uniprot Cloning, sequencing and characterization of the biosynthetic gene cluster of sanglifehrin A, a potent cyclophilin inhibitor.(Mol. Biosyst.) [2010] |
|
74
|
A7DWI7_STRTE (A7DWI7) |
|
|
1e-09 |
66.2 |
46% |
|
- Product
- Putative acyl carrier protein (ACP)
- Gene
- llpD
- Organism
- Streptomyces tendae
|
1uniprot Isolation of the lysolipin gene cluster of Streptomyces tendae Tu 4042.(Gene) [2010] |
|
77
|
C0JWB6_9ACTO (C0JWB6) |
|
|
3e-09 |
65.1 |
46% |
|
- Product
- PokP3
- Gene
- pokP3
- Organism
- Streptomyces diastatochromogenes
|
1uniprot[Pubmed] 19266534 Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009] |
|
78
|
Q2J5J5_FRASC (Q2J5J5) |
|
|
4e-09 |
65.1 |
46% |
|
- Product
- Phosphopantetheine-binding
- Gene
- Francci3_4099
- Organism
- Frankia sp. (strain CcI3)
|
1uniprot[Pubmed] 17151343 Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007] |
|
79
|
Q2MGC9_STRGR (Q2MGC9) |
|
|
5e-09 |
64.3 |
40% |
|
- Product
- ACP
- Gene
-
- Organism
- Streptomyces griseus
|
1uniprot[Pubmed] 16305230 Cloning, sequencing, analysis, and heterologous expression of the fredericamycin biosynthetic gene cluster from Streptomyces griseus.(J. Am. Chem. Soc.) [2005] |
|
80
|
B0LJ41_9ACTO (B0LJ41) |
|
|
8e-09 |
63.9 |
42% |
|
- Product
- Lcz24
- Gene
- lcz24
- Organism
- Streptomyces sanglieri
|
1uniprot[Pubmed] 18070976 Biosynthetic investigations of lactonamycin and lactonamycin z: cloning of the biosynthetic gene clusters and discovery of an unusual starter unit.(Antimicrob. Agents Chemother.) [2008] |
|
81
|
ACPX_STRCM (P41174) |
|
|
9e-09 |
63.5 |
51% |
|
- Product
- Monensin polyketide synthase acyl carrier protein
- Gene
-
- Organism
- Streptomyces cinnamonensis
|
1uniprot[Pubmed] 1508151 [Medline] 92374994 Characterisation of actI-homologous DNA encoding polyketide synthase genes from the monensin producer Streptomyces cinnamonensis.(Mol. Gen. Genet.) [1992] |
|
83
|
E2EKK1_9ACTO (E2EKK1) |
|
|
1e-08 |
63.2 |
42% |
|
- Product
- Acyl carrier protein
- Gene
- sanH
- Organism
- Streptomyces sp. SANK 61196
|
1uniprot[Pubmed] 20550125 Cloning, sequencing, heterologous expression, and mechanistic analysis of A-74528 biosynthesis.(J. Am. Chem. Soc.) [2010] |
|
84
|
Q54497_STRNO (Q54497) |
|
|
2e-08 |
62.8 |
47% |
|
- Product
- Snoa3
- Gene
- snoa3
- Organism
- Streptomyces nogalater
|
1uniprot[Pubmed] 8668120 [Medline] 96242142 A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.(Mol. Gen. Genet.) [1996] | 2uniprot[Pubmed] 9349712 [Medline] 98007868 Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.(Mol. Gen. Genet.) [1997] | 3uniprot[Pubmed] 8760909 [Medline] 96349102 Production of hybrid anthracycline antibiotics by heterologous expression of Streptomyces nogalater nogalamycin biosynthesis genes.(Microbiology) [1996] | [pubmed all]
|
86
|
D7RFJ7_AMYOR (D7RFJ7) |
|
|
3e-08 |
62 |
48% |
|
- Product
- Putative acyl carrier protein
- Gene
- bexC
- Organism
- Amycolatopsis orientalis subsp. vinearia
|
1uniprot[Pubmed] 20443562 A biosynthetic pathway for BE-7585A, a 2-thiosugar-containing angucycline-type natural product.(J. Am. Chem. Soc.) [2010] |
|
87
|
Q7X2H6_9ACTO (Q7X2H6) |
|
|
3e-08 |
62 |
45% |
|
- Product
- Putative acyl carrier protein
- Gene
- gilC
- Organism
- Streptomyces griseoflavus
|
1uniprot[Pubmed] 12822997 [Medline] 22708304 The complete gene cluster of the antitumor agent gilvocarcin V and its implication for the biosynthesis of the gilvocarcins.(J. Am. Chem. Soc.) [2003] |
|
88
|
D8I4L9_AMYMU (D8I4L9) |
|
|
8e-08 |
60.8 |
44% |
|
- Product
- 3-oxoacyl-ACP synthase acylcarrier protein
- Gene
- actI
AMED_5433
- Organism
- Amycolatopsis mediterranei (strain U-32)
|
1uniprot[Pubmed] 20567260 Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010] |
|
89
|
Q9F6D5_9ACTO (Q9F6D5) |
|
|
9e-08 |
60.5 |
44% |
|
- Product
- Acyl carrier protein
- Gene
- zhuG
- Organism
- Streptomyces sp. R1128
|
1uniprot[Pubmed] 10931852 [Medline] 20517899 Cloning, nucleotide sequence, and heterologous expression of the biosynthetic gene cluster for R1128, a non-steroidal estrogen receptor antagonist. Insights into an unusual priming mechanism.(J. Biol. Chem.) [2000] |
|
93
|
B0LJ07_9ACTO (B0LJ07) |
|
|
2e-07 |
59.3 |
44% |
|
- Product
- Lct24
- Gene
- lct24
- Organism
- Streptomyces rishiriensis
|
1uniprot[Pubmed] 18070976 Biosynthetic investigations of lactonamycin and lactonamycin z: cloning of the biosynthetic gene clusters and discovery of an unusual starter unit.(Antimicrob. Agents Chemother.) [2008] |
|
94
|
Q9ZAU0_STRPE (Q9ZAU0) |
|
|
4e-07 |
58.5 |
45% |
|
- Product
- Daunorubicin acyl carrier protein
- Gene
- dpsG
- Organism
- Streptomyces peucetius
|
1uniprot[Pubmed] 9864344 [Medline] 99084971 Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene.(J. Bacteriol.) [1999] |
|
95
|
C7N0D3_SACVD (C7N0D3) |
|
|
4e-07 |
58.2 |
37% |
|
- Product
- Acyl carrier protein
- Gene
- Svir_33710
- Organism
- Saccharomonospora viridis (strain ATCC 15386 / DSM 43017 / JCM 3036 / NBRC 12207 / P101)
|
1uniprot Complete genome sequence of Saccharomonospora viridis type strain (P101T).(Stand. Genomic Sci.) [2009] |
|
96
|
Q53878_STRS5 (Q53878) |
|
|
5e-07 |
57.8 |
45% |
|
- Product
- Acyl carrier protein
- Gene
- dauA(g)
- Organism
- Streptomyces sp. (strain C5)
|
1uniprot[Pubmed] 8655529 [Medline] 96236066 Cloning, sequencing, and analysis of aklaviketone reductase from Streptomyces sp. strain C5.(J. Bacteriol.) [1996] |
|
97
|
Q53673_STRAA (Q53673) |
|
|
6e-07 |
57.8 |
41% |
|
- Product
- Acyl carrier protein
- Gene
- mtmS
- Organism
- Streptomyces argillaceus
|
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996] | 2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996] | 3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997] | 4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998] | 5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999] | 6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999] | 7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000] | 8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001] | 9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003] | 10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999] | 11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002] | 12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000] | 13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000] | 14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002] | 15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003] | 16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996] | 17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004] | 18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997] | 19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005] | 20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000] | [pubmed all]
|
98
|
E1ARN2_STRAU (E1ARN2) |
|
|
1e-06 |
56.2 |
48% |
|
- Product
- Putative acyl carrier protein
- Gene
- sa22
- Organism
- Streptomyces aureofaciens
|
1uniprot[Pubmed] 21393365 The role of two SARP family transcriptional regulators in regulation of the auricin gene cluster in Streptomyces aureofaciens CCM 3239.(Microbiology) [2011] |
|
99
|
O32453_9ACTO (O32453) |
|
|
2e-06 |
55.8 |
53% |
|
- Product
- ORF 3
PdmC
- Gene
- pdmC
- Organism
- Actinomadura hibisca
|
1uniprot[Pubmed] 9339544 [Medline] 97480928 Cloning and nucleotide sequence of the putative polyketide synthase genes for pradimicin biosynthesis from Actinomadura hibisca.(Biosci. Biotechnol. Biochem.) [1997] |
|
100
|
Q8KSY8_9ACTO (Q8KSY8) |
|
|
3e-06 |
55.5 |
45% |
|
- Product
- Putative acyl carrier protein GrhC
- Gene
- grhC
- Organism
- Streptomyces sp. JP95
|
1uniprot[Pubmed] 12323376 [Medline] 22235582 A gene cluster from a marine Streptomyces encoding the biosynthesis of the aromatic spiroketal polyketide griseorhodin A.(Chem. Biol.) [2002] |
|