Acid resistance (by GABA antiporter)(NFUNC_0071) |
必須 | A | GAD (NRULE_0231) | Glutamate decarboxylase | EFER_1575 EFER_2817 |
GADC (NRULE_0234) | Glutamate/gamma-aminobutyrate antiporter | EFER_1577 |
Alanine racemization(NFUNC_0063) |
必須 | A | ALR (NRULE_0228) | Alanine racemase | EFER_1765 EFER_4143 EFER_3824 |
Aminoglycoside resistance (by aminoglycoside O-phosphotransferase)(NFUNC_0043) |
必須 | A | APH6 (NRULE_0155) | Streptomycin 6-kinase | EFER_p0049 |
B | APH3 (NRULE_0156) | Aminoglycoside 3'-phosphotransferase | EFER_p0048 |
Ampicillin resistance(NFUNC_0046) |
必須 | A | BLAA (NRULE_0122) | Beta-lactamase class A | EFER_1643 EFER_p0036 |
Anthranilate biosynthesis(NFUNC_0038) |
必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | EFER_3333 EFER_1693 |
TRPE (NRULE_0143) | Anthranilate synthase component I | EFER_1692 |
Aromatic azo compounds degradation(NFUNC_0073) |
必須 | A | AZOR (NRULE_0236) | FMN-dependent NADH-azoreductase | EFER_1589 |
Arsenical resistance(NFUNC_0004) |
必須 | A | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | EFER_3498 |
ARSC1 (NRULE_0017) | Arsenate reductase | EFER_3499 EFER_0681 |
Bacitracin resistance(NFUNC_0022) |
必須 | A | UPPP (NRULE_0097) | Undecaprenyl-diphosphatase | EFER_3002 |
Beta-lactam antibiotic resistance(NFUNC_0033) |
必須 | A | BLAA (NRULE_0122) | Beta-lactamase class A | EFER_p0036 EFER_1643 |
C | BLAC (NRULE_0124) | Beta-lactamase class C | EFER_4204 |
Biotin biosynthesis(NFUNC_0051) |
必須 | A | BIOF (NRULE_0182) | 8-amino-7-oxononanoate synthase | EFER_2337 |
BIOA (NRULE_0183) | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | EFER_2339 |
BIOD (NRULE_0184) | ATP-dependent dethiobiotin synthetase BioD | EFER_2334 EFER_1443 |
BIOB (NRULE_0185) | Biotin synthase | EFER_2338 |
Catechol degradation (beta-ketoadipate pathway)(NFUNC_0013) |
必須 | A | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | EFER_1481 |
CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | EFER_1479 |
CATC (NRULE_0054) | Muconolactone isomerase | EFER_1480 |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | EFER_1632 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | EFER_1636 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | EFER_1635 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | EFER_1634 EFER_1599 |
B | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | EFER_1481 |
CATC (NRULE_0054) | Muconolactone isomerase | EFER_1480 |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | EFER_1632 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | EFER_1636 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | EFER_1635 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | EFER_1634 EFER_1599 |
CATB1 (NRULE_0386) | Muconate cycloisomerase | EFER_1479 |
Cephalosporin resistance(NFUNC_0048) |
必須 | A | BLAC (NRULE_0124) | Beta-lactamase class C | EFER_4204 |
任意 | | BLAA (NRULE_0122) | Beta-lactamase class A | EFER_p0036 EFER_1643 |
Folate biosynthesis(NFUNC_0044) |
必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | EFER_1693 EFER_3333 |
DHPS (NRULE_0144) | Dihydropteroate synthase | EFER_3154 |
FOLM (NRULE_0146) | Dihydrofolate reductase FolM | EFER_1431 |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | EFER_0860 EFER_3003 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | EFER_0165 |
FOLC (NRULE_0160) | Bifunctional protein FolC | EFER_0848 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | EFER_1264 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | EFER_1831 |
B | GLAT (NRULE_0142) | Glutamine amidotransferase | EFER_1693 EFER_3333 |
DHPS (NRULE_0144) | Dihydropteroate synthase | EFER_3154 |
FOLA (NRULE_0147) | Dihydrofolate reductase | EFER_0056 |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | EFER_3003 EFER_0860 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | EFER_0165 |
FOLC (NRULE_0160) | Bifunctional protein FolC | EFER_0848 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | EFER_1264 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | EFER_1831 |
GABA biosynthesis(NFUNC_0066) |
必須 | A | GAD (NRULE_0231) | Glutamate decarboxylase | EFER_1575 EFER_2817 |
4-hydroxyphenylacetate degradation(NFUNC_0068) |
必須 | A | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | EFER_3070 |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | EFER_3071 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | EFER_3064 |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | EFER_3063 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | EFER_3065 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | EFER_3062 |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | EFER_3066 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | EFER_3067 |
C | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | EFER_3070 |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | EFER_3071 EFER_0802 EFER_1469 EFER_1476 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | EFER_3064 |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | EFER_3063 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | EFER_3065 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | EFER_3062 |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | EFER_3066 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | EFER_3067 |
Kanamycin resistance(NFUNC_0052) |
必須 | C | APH3 (NRULE_0156) | Aminoglycoside 3'-phosphotransferase | EFER_p0048 |
Macrolide antibiotic resistance(NFUNC_0045) |
必須 | B | RLMA (NRULE_0165) | 23S rRNA (guanine-N(1))-methyltransferase | EFER_1253 |
C | MACA (NRULE_0166) | Macrolide-specific efflux protein MacA | EFER_1026 |
MACB (NRULE_0167) | Macrolide export ATP-binding/permease protein MacB | EFER_1027 |
Metal-binding protein(NFUNC_0105) |
必須 | A | MOP (NRULE_0322) | Putative molybdenum-binding protein | EFER_0345 EFER_2344 EFER_2348 |
B | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | EFER_2348 |
C | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | EFER_4126 EFER_0748 EFER_2346 EFER_3856 |
E | CUER (NRULE_0328) | Copper-responsive transcriptional regulator CueR | EFER_0545 |
F | SOXR (NRULE_0329) | Redox-sensitive transcriptional activator SoxR | EFER_4164 |
G | ZNTR (NRULE_0330) | Zinc-responsive transcriptional regulator ZntR | EFER_3276 |
H | NIKR (NRULE_0331) | Nickel-responsive transcriptional regulator NikR | EFER_3468 |
I | ISCR (NRULE_0332) | Rrf2 family transcriptional regulator IscR | EFER_0641 |
Molybdate transport (ABC transporter)(NFUNC_0097) |
必須 | A | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | EFER_0748 EFER_4126 EFER_2346 EFER_3856 |
任意 | | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | EFER_2348 |
| MODB (NRULE_0325) | Molybdate ABC transporter permease protein | EFER_2345 |
| MODC (NRULE_0326) | Molybdate ABC transporter ATP-binding protein | EFER_2344 |
(R)-pantothenate biosynthesis(NFUNC_0030) |
必須 | A | PAND (NRULE_0115) | Aspartate 1-decarboxylase | EFER_0152 |
PANB (NRULE_0116) | 3-methyl-2-oxobutanoate hydroxymethyltransferase | EFER_0156 |
PANE (NRULE_0117) | 2-dehydropantoate 2-reductase | EFER_2600 |
PANC (NRULE_0118) | Pantothenate synthetase | EFER_0155 |
Penicillin resistance(NFUNC_0047) |
必須 | A | BLAA (NRULE_0122) | Beta-lactamase class A | EFER_p0036 EFER_1643 |
Phenol degradation(NFUNC_0028) |
必須 | B | PHEA1 (NRULE_0083) | Aromatic ring hydroxylase | EFER_3070 |
任意 | | FDR1 (NRULE_0032) | Oxygenase electron transfer component | EFER_1484 EFER_0801 EFER_1017 EFER_1604 |
| FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | EFER_0798 EFER_1482 |
| FADR1 (NRULE_0101) | NADH-dependent flavin reductase | EFER_1476 EFER_0802 EFER_1469 EFER_3071 |
Phytic acid hydrolysis(NFUNC_0085) |
必須 | B | APPA (NRULE_0259) | Periplasmic AppA protein | EFER_3043 |
Polymyxin resistance(NFUNC_0036) |
必須 | A | ARNA (NRULE_0132) | Bifunctional polymyxin resistance protein ArnA | EFER_0914 |
ARNB (NRULE_0133) | UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase | EFER_0916 |
ARNC (NRULE_0134) | Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase | EFER_0915 |
ARND (NRULE_0135) | Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD | EFER_0913 |
ARNE (NRULE_0136) | Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE | EFER_0911 |
ARNF (NRULE_0137) | Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF | EFER_0910 |
ARNT (NRULE_0138) | Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase | EFER_0912 |
Protocatechuate degradation (beta-ketoadipate pathway)(NFUNC_0014) |
必須 | A | PCAG (NRULE_0066) | Protocatechuate 3,4-dioxygenase alpha subunit | EFER_1501 |
PCAH (NRULE_0067) | Protocatechuate 3,4-dioxygenase beta subunit | EFER_1502 |
PCAB (NRULE_0068) | 3-carboxy-cis,cis-muconate cycloisomerase | EFER_1633 |
PCAC (NRULE_0069) | 4-carboxymuconolactone decarboxylase | EFER_1631 |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | EFER_1632 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | EFER_1636 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | EFER_1635 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | EFER_1634 EFER_1599 |
Riboflavin biosynthesis(NFUNC_0058) |
必須 | A | RIBB (NRULE_0200) | 3,4-dihydroxy-2-butanone 4-phosphate synthase | EFER_2990 |
RIBA (NRULE_0201) | GTP cyclohydrolase-2 | EFER_1677 |
RIBD (NRULE_0202) | Riboflavin biosynthesis protein RibD | EFER_2611 |
RIBH (NRULE_0203) | 6,7-dimethyl-8-ribityllumazine synthase | EFER_2610 |
RIBE (NRULE_0204) | Riboflavin synthase | EFER_1382 |
任意 | | RIBF (NRULE_0205) | Riboflavin biosynthesis protein RibF | EFER_0017 |
Streptomycin resistance(NFUNC_0054) |
必須 | C | APH6 (NRULE_0155) | Streptomycin 6-kinase | EFER_p0049 |
任意 | | APH3 (NRULE_0156) | Aminoglycoside 3'-phosphotransferase | EFER_p0048 |
Trehalose biosynthesis (from NDP-glucose and glucose-6-phosphate)(NFUNC_0031) |
必須 | A | TPS (NRULE_0119) | Trehalose-phosphate synthase | EFER_1127 |
TPP (NRULE_0120) | Trehalose-6-phosphate phosphatase | EFER_1126 |
Uptake of osmoprotectant(NFUNC_0061) |
必須 | A | OPUAC (NRULE_0213) | Osmoprotectant ABC transporter substrate-binding protein | EFER_0391 |
OPUAB (NRULE_0214) | Osmoprotectant ABC transporter permease protein | EFER_0392 |
OPUAA (NRULE_0215) | Osmoprotectant ABC transporter ATP-binding protein | EFER_1445 EFER_0393 |
C | BCCT (NRULE_0220) | BCCT family transporter | EFER_0048 |
D | PROP (NRULE_0221) | Osmoprotectant transporter | EFER_4170 |
E | OPUE (NRULE_0222) | Sodium/proline symporter | EFER_1912 |
Vitamin B6 biosynthesis (PdxA/PdxJ pathway)(NFUNC_0060) |
必須 | A | EPD (NRULE_0208) | D-erythrose-4-phosphate dehydrogenase | EFER_2859 |
PDXB (NRULE_0209) | Erythronate-4-phosphate dehydrogenase | EFER_0843 |
SERC (NRULE_0210) | Phosphoserine aminotransferase | EFER_1052 |
PDXA (NRULE_0211) | 4-hydroxythreonine-4-phosphate dehydrogenase | EFER_0063 |
PDXJ (NRULE_0212) | Pyridoxine 5'-phosphate synthase | EFER_0510 |