Rule : Arsenate reductase (ARSC1)

Rule Description

ID	NRULE_0017
Rule name	ARSC1
Created	2012-07-10
Protein name	Protein name Full Arsenate reductase EC EC 1.20.4.1
Gene name	arsC
Rule Trigger	TIGRFAMs; TIGR00014; hit=1
Cross Reference	Gene Ontology GO GO:0008794, F:arsenate reductase (glutaredoxin) activity, IEA:EC GO:0046685, P:response to arsenic-containing substance, IEA:UniProtKB-KW Phylogenomic databases HOGENOM HOG000059717, - KO K00537, - Family and domain databases InterPro IPR006659, Arsenate_reductase IPR006660, Arsenate_reductase-like IPR012336, Thioredoxin-like_fold Pfam PF03960, ArsC, 1 TIGRFAMs TIGR00014, ArsC, 1 PROSITE PS51353, ARSC, 1
Feature	Not assigned
General annotation	Function Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance Catalytic activity Arsenate + glutaredoxin = arsenite + glutaredoxin disulfide + H(2)O Sequence similarities Belongs to the ArsC family
Reference	P08692 Escherichia coli. 3021763 Nucleotide sequence of the structural genes for an anion pump. The plasmid-encoded arsenical resistance operon. (J Biol Chem. 1986) 1703401 Molecular analysis of an anion pump: purification of the ArsC protein. (Arch Biochem Biophys. 1991) 1704144 The plasmid-encoded arsenical resistance pump: an anion-translocating ATPase. (Res Microbiol. 1990) P0AB96 Escherichia coli (strain K12). 7721697 An Escherichia coli chromosomal ars operon homolog is functional in arsenic detoxification and is conserved in gram-negative bacteria. (J Bacteriol. 1995)

Related Function

Function name
Arsenical resistance

CDS


Scientific name	NBRC No.	CDS	Product name
Acetobacter aceti	14818	AaceN1_010100015122	arsenate reductase
Acetobacter aceti	14818	AaceN1_010100016733	arsenate reductase
Acetobacter pasteurianus	105190	APA32_42360	Arsenate reductase
Acetobacter pasteurianus	105190	APA32_42450	Arsenate reductase
Acetobacter pasteurianus	101655	APT_1668	arsenate reductase
Acetobacter tropicalis	101654	ATPR_0417	arsenate reductase
Acidiphilium multivorum	100883	ACMV_26680	arsenate reductase
		ACMV_31450	arsenate reductase
		ACMV_P2_00130	arsenate reductase
Acinetobacter radioresistens	102413	ACRAD_32_00280	arsenate reductase
Acinetobacter radioresistens	102413	ACRAD_60_00190	arsenate reductase
Acinetobacter sp.	100985	ACT4_006_00480	putative arsenate reductase
Alteromonas macleodii	102226	MASE_10215	putative arsenate reductase ArsC
Azorhizobium caulinodans	14845	AZC_1271	arsenate reductase
Azorhizobium caulinodans	14845	AZC_4550	arsenate reductase
Bradyrhizobium diazoefficiens	14792	bll3084	arsenate reductase
Brevundimonas diminuta	12697	BDIM_02850	arsenate reductase glutaredoxin
Brevundimonas diminuta	12697	BDIM_14010	arsenate reductase glutaredoxin
Brevundimonas subvibrioides	16000	Bresu_0887	arsenate reductase
Caulobacter segnis	15250	Cseg_2397	arsenate reductase
		Cseg_2459	arsenate reductase
		Cseg_3180	arsenate reductase
Cellulophaga lytica	14961	Celly_2712	arsenate reductase
Chromobacterium violaceum	12614	CV_0770	probable arsenate reductase (glutaredoxin)
Corynebacterium callunae	15359	H924_05150	arsenate reductase
Corynebacterium efficiens	100395	CE1150	putative arsenate reductase
Corynebacterium glutamicum	12168	Cgl1094	Arsenate reductase and related proteins, glutaredoxin family
Corynebacterium glutamicum	12153	KIQ_09260	arsenate reductase
Corynebacterium matruchotii	15360	HMPREF0299_5487	arsenate reductase
Cupriavidus metallidurans	102507	Rmet_0329	arsenate reductase (glutaredoxin family) CMGI-7
Cupriavidus metallidurans	102507	Rmet_3436	putative oxidoreductase
Cytophaga hutchinsonii	15051	CHU_1588	arsenate reductase (glutaredoxin)
Edwardsiella tarda	105688	ET1_03_01530	arsenate reductase
Edwardsiella tarda	105688	ET1_19_00490	putative oxidoreductase
Enterobacter aerogenes	13534	EAE_00555	hypothetical protein
Enterobacter aerogenes	13534	EAE_23975	arsenate reductase
Enterobacter cloacae subsp. cloacae	13535	ECL_00465	arsenate reductase
		ECL_02871	putative arsenate reductase
		ECL_03781	putative arsenate reductase
		ECL_A100	Arsenate reductase
Enterobacter hormaechei	105718	HMPREF9086_1004	arsenate reductase
		HMPREF9086_2608	arsenate reductase
		HMPREF9086_3318	arsenate reductase
Escherichia coli	3972	EcolC_0213	arsenate reductase
Escherichia coli	3972	EcolC_1181	arsenate reductase
Escherichia coli	13500	WFL_13315	putative oxidoreductase
Escherichia coli	13500	WFL_18380	arsenate reductase
Escherichia coli	12713	Y75_2488	predicted oxidoreductase
Escherichia coli	12713	Y75_3718	arsenate reductase
Escherichia fergusonii	102419	EFER_0681	putative oxidoreductase
Escherichia fergusonii	102419	EFER_3499	arsenate reductase
Escherichia hermannii	105704	EH105704_01_08790	hypothetical protein YfgD
		EH105704_06_01400	arsenate reductase
		EH105704_33_00030	arsenate reductase
Flavobacterium johnsoniae	14942	Fjoh_4784	arsenate reductase
Fluviicola taffensis	106335	Fluta_1935	arsenate reductase
Frateuria aurantia	3245	Fraau_2438	glutaredoxin-dependent arsenate reductase
Gluconobacter frateurii	101659	GfraN1_010100014361	arsenate reductase
Gordonia aichiensis	108223	GOACH_13_00390	arsenate reductase
Gordonia alkanivorans	16433	GOALK_038_00940	arsenate reductase
Gordonia amarae	15530	GOAMR_34_00080	arsenate reductase
Gordonia amicalis	100051	GOAMI_26_00210	arsenate reductase
Gordonia araii	100433	GOARA_067_00490	arsenate reductase
Gordonia bronchialis	16047	Gbro_1542	arsenate reductase
Gordonia effusa	100432	GOEFS_115_00040	arsenate reductase
Gordonia hirsuta	16056	GOHSU_19_00100	arsenate reductase
Gordonia namibiensis	108229	GONAM_24_00050	arsenate reductase
Gordonia otitidis	100426	GOOTI_252_00060	arsenate reductase
Gordonia polyisoprenivorans	16320	GOPIP_064_00160	arsenate reductase
Gordonia rhizosphera	16068	GORHZ_247_00970	arsenate reductase
Gordonia rubripertincta	101908	GORBP_108_00150	arsenate reductase
Gordonia sihwensis	108236	GSI01S_19_00680	arsenate reductase
Gordonia sihwensis	108236	GSI01S_32_00260	arsenate reductase
Gordonia soli	108243	GS4_16_01100	arsenate reductase
Gordonia sputi	100414	GOSPT_089_00550	arsenate reductase
Gordonia terrae	100016	GOTRE_130_00190	arsenate reductase
Hyphomonas neptunium	14232	HNE_0991	arsenate reductase
Klebsiella pneumoniae	14438	KPR_1725
Klebsiella pneumoniae	14438	KPR_1887
Klebsiella pneumoniae subsp. rhinoscleromatis	105682	HMPREF0484_0206	arsenate reductase
Klebsiella pneumoniae subsp. rhinoscleromatis	105682	HMPREF0484_2297	arsenate reductase
Kordia algicida	100336	KAOT1_02642	arsenate reductase
Labrenzia aggregata	16684	SIAM614_19681	arsenate reductase
Magnetospirillum gryphiswaldense	15271	MGR_0182	Arsenate reductase and related
Magnetospirillum magnetotacticum	15272	Magn03004639	COG1393: Arsenate reductase and related proteins, glutaredoxin family
		Magn03009434	COG1393: Arsenate reductase and related proteins, glutaredoxin family
		Magn03009514	COG1393: Arsenate reductase and related proteins, glutaredoxin family
		Magn03010916	COG1393: Arsenate reductase and related proteins, glutaredoxin family
Marinomonas mediterranea	103028	Marme_2540	arsenate reductase
Mariprofundus ferrooxydans		SPV1_12982	arsenate reductase
Marivirga tractuosa	15989	Ftrac_0848	arsenate reductase
Methylobacterium radiotolerans	15690	Mrad2831_1379	arsenate reductase
Microscilla marina	16560	M23134_06542	arsenate reductase
Myroides odoratus	14945	Myrod_0902	arsenate reductase
Nitriliruptor alkaliphilus		NitalDRAFT_2769	arsenate reductase
Nitrospina gracilis		NITGR_1060036	putative oxidoreductase
Ochrobactrum anthropi	15819	Oant_2198	arsenate reductase
Ochrobactrum anthropi	15819	Oant_3199	arsenate reductase
Ochrobactrum intermedium	15820	OINT_1001095	arsenate reductase
Phaeobacter gallaeciensis	16654	PGA1_c12140	putative arsenate reductase
Photobacterium damselae subsp. damselae corrig.	15633	VDA_001411	arsenate reductase
Proteus mirabilis	105697	HMPREF0693_1195	arsenate reductase
Providencia alcalifaciens	105687	PROVALCAL_01951	arsenate reductase
Pseudomonas putida	100650	PP_1645	arsenate reductase
Pseudomonas stutzeri	14165	PSTAB_2848	arsenate reductase
Rahnella aquatilis	105701	Rahaq2_3345	glutaredoxin-dependent arsenate reductase
Rahnella aquatilis	105701	Rahaq2_4920	glutaredoxin-dependent arsenate reductase
Rhizobium etli	15573	RHE_CH02534	arsenate reductase protein
Rhizobium sp.	101917	NGR_b21790	arsenate reductase
Rhizobium tropici	15247	RTCIAT899_CH02585	arsenate reductase ArsC
Rhodococcus erythropolis	100887	RER_43750	putative arsenate reductase
Rhodococcus opacus	108011	ROP_57170	arsenate reductase
Serratia odorifera	102598	HMPREF0758_2596	arsenate reductase
Serratia odorifera	102598	HMPREF0758_3145	arsenate reductase
Shimwellia blattae	105725	EB105725_12_00830	hypothetical protein YfgD
Shimwellia blattae	105725	EB105725_15_00220	arsenate reductase
Solitalea canadensis	15130	Solca_4385	glutaredoxin-dependent arsenate reductase
Sphingobacterium spiritivorum	14948	HMPREF0766_14305	putative arsenate reductase
Sphingobium japonicum	101211	SJA_C1-04250	arsenate reductase
		SJA_C1-16310	ArsC-family protein
		SJA_C1-33220	arsenate reductase
Sphingobium sp.	103272	SLG_06250	arsenate reductase
		SLG_16250	putative arsenate reductase
		SLG_p_01430	arsenate reductase
Sphingomonas echinoides	15742	SechA1_010100009988	arsenate reductase
Sphingomonas echinoides	15742	SechA1_010100014190	arsenate reductase
Sphingomonas wittichii	105917	Swit_2243	arsenate reductase
Sphingomonas wittichii	105917	Swit_4697	arsenate reductase
Stackebrandtia nassauensis	102104	Snas_3935	arsenate reductase
Starkeya novella	14993	Snov_1589	arsenate reductase
Thauera linaloolentis	102519	C666_01745	arsenate reductase
Thauera linaloolentis	102519	C666_06960	arsenate reductase
Tsukamurella paurometabola	16120	Tpau_3196	arsenate reductase
Vibrio alginolyticus	15630	N646_1384	arsenate reductase
Vibrio ichthyoenteri	15847	VII00023_16711	arsenate reductase
Vibrio metschnikovii	103153	VIB_000746	arsenate reductase
Vibrio orientalis	15638	VIOR3934_07818	arsenate reductase
Vibrio tubiashii	15644	VITU9109_23679	arsenate reductase
Vibrio vulnificus	15645	B736_00095	arsenate reductase
Yersinia bercovieri	105717	yberc0001_29230	Arsenate reductase
Yersinia bercovieri	105717	yberc0001_3050	Arsenate reductase
Yersinia rohdei	105715	yrohd0001_23340	Arsenate reductase
Yersinia rohdei	105715	yrohd0001_31750	Arsenate reductase