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遺伝子 : FMN-dependent NADH-azoreductase (AZOR)

遺伝子情報

ID NRULE_0236
遺伝子ID AZOR
作成日 2013/08/26
タンパク質名
Protein name
Full
FMN-dependent NADH-azoreductase
EC
EC 1.7.-.-
Synonym
Full
Azo-dye reductase
FMN-dependent NADH-azo compound oxidoreductase
遺伝子名 azoR
遺伝子条件 HAMAP; MF_01216; hit=1
参照
Gene Ontology
GO
GO:0050446, F:azobenzene reductase activity, IDA:EcoCyc
GO:0009055, F:electron carrier activity, IEA:HAMAP
GO:0010181, F:FMN binding, IDA:EcoCyc
GO:0008752, F:FMN reductase activity, IEA:HAMAP
GO:0016652, F:oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor, IEA:HAMAP
GO:0016655, F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor, IDA:EcoCyc
GO:0006979, P:response to oxidative stress, IMP:EcoCyc
Phylogenomic databases
eggNOG
COG1182, -
HOGENOM
HOG000247892, -
KO
K01118, -
ProtClustDB
PRK00170, -
Enzyme and pathway databases
BioCyc
MetaCyc:G6731-MONOMER, -
Family and domain databases
HAMAP
MF_01216, Azoreductase_type1, 1, -
InterPro
IPR003680, Flavodoxin_fold
IPR023048, NADH-azoreductase_FMN-depdnt
Pfam
PF02525, Flavodoxin_2, 1
配列の特徴
P41407 Escherichia coli (strain K12).
NP_BIND16 - 18FMN.
NP_BIND96 - 99FMN.
NP_BIND140 - 145FMN.
BINDING10FMN.
注釈
Function
Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity. The enzyme can reduce ethyl red and methyl red, but is not able to convert sulfonated azo dyes
Cofactor
Binds 1 FMN per subunit
Subunit structure
Homodimer
Sequence similarities
Belongs to the azoreductase type 1 family
参考文献
P41407 Escherichia coli (strain K12).
16738553
Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. (Mol Syst Biol. 2006)
11583992
Putative ACP phosphodiesterase gene (acpD) encodes an azoreductase. (J Biol Chem. 2001)



関与する機能

機能名
Aromatic azo compounds degradation

該当CDS

データダウンロード
学名 NBRC番号 CDS タンパク質名
Acaryochloris marina102967AM1_4919fmn-dependent NADH-azoreductase, putative
Acidobacterium capsulatum15755ACP_3099acyl carrier protein phosphodiesterase
Acinetobacter sp.100985ACT4_013_00690FMN-dependent NADH-azoreductase
Actinosynnema mirum14064Amir_1069NAD(P)H dehydrogenase (quinone)
Alteromonas macleodii102226MASE_10465(acyl-carrier-protein) phosphodiesterase
Amycolatopsis azurea14573C791_4092FMN-dependent NADH-azoreductase
C791_6695FMN-dependent NADH-azoreductase
Amycolatopsis mediterranei13415RAM_24775FMN-dependent NADH-azoreductase
RAM_30070FMN-dependent NADH-azoreductase
Anoxybacillus flavithermus15317Aflv_2040Acyl carrier protein phosphodiesterase
Azorhizobium caulinodans14845AZC_1287acyl carrier protein phosphodiesterase
Bacillus amyloliquefaciens15535BAMF_0457acyl carrier protein phosphodiesterase 3; NAD(P)H dehydrogenase
BAMF_1992Acyl carrier protein phosphodiesterase
BAMF_3202azoreductase
Bacillus atrophaeus13721BATRMS_15_00210azoreductase
BATRMS_17_00430azoreductase
Bacillus cereus15305BC_1835FMN-dependent NADH-azoreductase
BC_2194FMN-dependent NADH-azoreductase
BC_5410FMN-dependent NADH-azoreductase
Bacillus licheniformis12200BL00833putative NAD(P)H dehydrogenase YvaB
BL01874NAD(P)H dehydrogenase
Bacillus licheniformis12195BLi02245FMN-dependent NADH-azoreductase AzoR
BLi03573FMN-dependent NADH-azoreductase AzoR
Bacillus mojavensis15718GYU_03_02780azoreductase
Bacillus mycoides101228bmyco0001_16910FMN-dependent NADH-azoreductase 1
bmyco0001_19650FMN-dependent NADH-azoreductase 2
bmyco0001_49750FMN-dependent NADH-azoreductase 1
Bacillus pseudomycoides101232bpmyx0001_19910FMN-dependent NADH-azoreductase 2
bpmyx0001_48520FMN-dependent NADH-azoreductase 1
bpmyx0001_56690FMN-dependent NADH-azoreductase 1
bpmyx0001_8310FMN-dependent NADH-azoreductase 1
Bacillus psychrosaccharolyticus101233WYK_184_00400FMN-dependent NADH-azoreductase 3
WYK_237_00070azoreductase
Bacillus pumilus12092BAT_0365fmn-dependent NADH-azoreductase 1 (fmn-dependent nadh-azocompound oxidoreductase 1) (azo-dye reductase 1)
BAT_3700fmn-dependent NADH-azoreductase 2 (fmn-dependent nadh-azocompound oxidoreductase 2) (azo-dye reductase 2)
Bacillus subtilis3134BSU6633_04889azoreductase
BSU6633_05219azoreductase
Bacillus subtilis subsp. subtilis13719BSU19230antitoxin of ribonuclease RttI
BSU33540NADH:dichloroindophenol oxidoreductase
Bacillus thuringiensis101235bthur0008_17250FMN-dependent NADH-azoreductase 1
bthur0008_20330FMN-dependent NADH-azoreductase 2
bthur0008_51860FMN-dependent NADH-azoreductase 1
Bacillus vallismortis101236BvalD_010100013157azoreductase
BvalD_010100019852azoreductase
Bradyrhizobium diazoefficiens14792bll3368putative acyl carrier protein phosphodiesterase (EC 3.1.4.14)
blr5106acyl-carrier-protein phosphodiesterase
Brevibacillus brevis100599BBR47_03690FMN-dependent NADH-azoreductase
Catenulispora acidiphila102108Caci_6778NAD(P)H dehydrogenase (quinone)
Chitinophaga pinensis15968Cpin_1692NAD(P)H dehydrogenase (quinone)
Cpin_2707NAD(P)H dehydrogenase (quinone)
Cpin_2757NAD(P)H dehydrogenase (quinone)
Cpin_3545NAD(P)H dehydrogenase (quinone)
Chromobacterium violaceum12614CV_2016[acyl-carrier-protein] phosphodiesterase
Chryseobacterium gleum15054HMPREF0204_11428flavodoxin-like protein
HMPREF0204_13370flavodoxin-like protein
Chthoniobacter flavusCfE428DRAFT_0360NAD(P)H dehydrogenase (quinone)
Clostridium acetobutylicum13948CA_C0604Acyl carrier protein phosphodiesterase
CA_C3421Acyl carrier protein phosphodiesterase
Conexibacter woesei100937Cwoe_0290NAD(P)H dehydrogenase (quinone)
Congregibacter litoralis104960KT71_17636Acyl carrier protein phosphodiesterase
Cupriavidus metallidurans102507Rmet_1590FMN-dependent NADH-azoreductase (FMN-dependent NADH-azo compound oxidoreductase) (Azo-dye reductase)
Rmet_3438FMN-dependent NADH-azoreductase 2 (FMN-dependent NADH-azo compound oxidoreductase 2) (Azo-dye reductase 2)
Cystobacter fuscus100088D187_002831FMN-dependent NADH-azoreductase
D187_003074FMN-dependent NADH-azoreductase
Desulfovibrio vulgaris subsp. vulgaris104121DVU_2548acyl carrier protein phosphodiesterase
Enterobacter aerogenes13534EAE_01360acyl carrier protein phosphodiesterase
EAE_20445azoreductase
Enterobacter cloacae subsp. cloacae13535ECL_02091azoreductase
Enterobacter hormaechei105718HMPREF9086_2280fmn-dependent NADH-azoreductase
Enterococcus gilvus100696I592_02234azoreductase
Enterococcus haemoperoxidus100709I583_00829FMN-dependent NADH-azoreductase
Enterococcus hirae3181EHR_02160acyl carrier protein
Enterococcus italicus107825HMPREF9088_0350flavodoxin-like protein
Enterococcus moraviensis100710I586_01763FMN-dependent NADH-azoreductase
Enterococcus pallens100697I588_01391hypothetical protein
Enterococcus phoeniculicola100711I589_00740FMN-dependent NADH-azoreductase
I589_03286hypothetical protein
Escherichia coli3972EcolC_2246NAD(P)H dehydrogenase (quinone)
Escherichia coli13500WFL_07530azoreductase
Escherichia coli12713Y75_1404NADH-azoreductase, FMN-dependent
Escherichia fergusonii102419EFER_1589NADH-azoreductase, FMN-dependent
Escherichia hermannii105704EH105704_12_00760FMN-dependent NADH-azoreductase
Flavobacterium johnsoniae14942Fjoh_3322NAD(P)H dehydrogenase (quinone)
Gemmata obscuriglobusGEMOB_RS28055azoreductase
Geodermatophilus obscurus13315Gobs_1788NAD(P)H dehydrogenase (quinone)
Gluconobacter frateurii101659GfraN1_010100007742ACP phosphodieterase
Gordonia soli108243GS4_26_01550FMN-dependent NADH-azoreductase
Halobacillus halophilus102448HBHAL_2558FMN-dependent NADH-azoreductase
Halomonas elongata15536HELO_1607NAD(P)H dehydrogenase (quinone)
HELO_3883(acyl-carrier protein) phosphodiesterase
Haloplasma contractileHLPCO_001663FMN-dependent NADH-azoreductase 1 protein
HLPCO_002005FMN-dependent NADH-azoreductase 2 protein
HLPCO_002390FMN-dependent NADH-azoreductase 2 protein
Hylemonella gracilis14920HGR_12697NAD(P)H dehydrogenase (quinone)
Hyphomonas neptunium14232HNE_0965acyl carrier protein phosphodiesterase
Kineococcus radiotolerans101839Krad_0234NAD(P)H dehydrogenase (quinone)
Klebsiella pneumoniae14438KPR_1296
KPR_2860
Klebsiella pneumoniae subsp. rhinoscleromatis105682HMPREF0484_3056NAD(P)H dehydrogenase (quinone)
HMPREF0484_4010flavodoxin-like protein
Kribbella flavida14399Kfla_3134NAD(P)H dehydrogenase (quinone)
Ktedonobacter racemiferKrac_7909NAD(P)H dehydrogenase (quinone)
Labrenzia aggregata16684SIAM614_19776Acyl carrier protein phosphodiesterase
SIAM614_26623(Acyl-carrier protein) phosphodiesterase
SIAM614_29186putative [acyl-carrier-protein] phosphodiesterase
Lactobacillus farciminis107150LfarK3_010100000710FMN-dependent NADH-azoreductase 2
LfarK3_010100003657acyl carrier protein phosphodiesterase (putative)
Lactobacillus plantarum subsp. plantarum15891HMPREF0531_11156flavodoxin-like protein
HMPREF0531_12298flavodoxin-like protein
Magnetospirillum gryphiswaldense15271MGR_0955NAD(P)H dehydrogenase (quinone)
Marinomonas mediterranea103028Marme_0594FMN-dependent NADH-azoreductase
Marme_2372FMN-dependent NADH-azoreductase
Mesoplasma florum100688Mfl046acyl carrier protein phosphodiesterase
Mfl052acyl carrier protein phosphodiesterase
Methylacidiphilum infernorumMinf_1829Acyl carrier protein phosphodiesterase
Methylobacterium radiotolerans15690Mrad2831_4469NAD(P)H dehydrogenase (quinone)
Microlunatus phosphovorus101784MLP_03100putative FMN-dependent NADH-azoreductase
MLP_48100putative FMN-dependent NADH-azoreductase
Micromonospora aurantiaca16155Micau_0650NAD(P)H dehydrogenase (quinone)
Mycoplasma hominis14850MHO_0860Acyl carrier protein phosphodiesterase
Mycoplasma hyorhinis14858F801_00695FMN-dependent NADH-azoreductase
Mycoplasma pneumoniae14401MPNE_0559putative NAD(P)H dehydrogenase (quinone)
Myroides odoratus14945Myrod_0247FMN-dependent NADH-azoreductase
Nakamurella multipartita105858Namu_1846NAD(P)H dehydrogenase (quinone)
Niastella koreensis106392Niako_2531FMN-dependent NADH-azoreductase
Nocardiopsis dassonvillei14626Ndas_5035NAD(P)H dehydrogenase (quinone)
Nostoc sp.all2105acyl carrier protein phosphodiesterase
Paenibacillus alvei3343PAV_11c01530FMN-dependent NADH-azoreductase AzoR
Paenibacillus peoriae15541PpeoK3_010100001385NAD(P)H dehydrogenase (quinone)
PpeoK3_010100001550azoreductase
PpeoK3_010100001820azoreductase
PpeoK3_010100007746azoreductase
Paenibacillus polymyxa15309PPT_11105azoreductase
Planctomyces brasiliensis103401Plabr_1007FMN-dependent NADH-azoreductase
Proteus mirabilis105697HMPREF0693_0741NAD(P)H dehydrogenase (quinone)
Providencia alcalifaciens105687PROVALCAL_00369flavodoxin-like protein
PROVALCAL_02954NAD(P)H dehydrogenase (quinone)
Pseudomonas putida100650PP_2866acyl carrier protein phosphodiesterase, putative
PP_4538acyl carrier protein phosphodiesterase, putative
Pseudomonas stutzeri14165PSTAB_1543NAD(P)H dehydrogenase (quinone)
Rahnella aquatilis105701Rahaq2_2249acyl carrier protein phosphodiesterase
Rhizobium etli15573RHE_CH01764[acyl-carrier-protein] phosphodiesterase protein
RHE_PC00047probable [acyl-carrier-protein] phosphodiesterase protein
Rhizobium sp.101917NGR_c11680putative acyl carrier protein phosphodiesterase
Rhizobium tropici15247RTCIAT899_CH07715FMN-dependent NADH-azoreductase
Rhodobacter sphaeroides12203RSP_3728putative acyl carrier protein phosphodiesterase
Rhodococcus erythropolis100887RER_13480putative azoreductase
Rothia dentocariosa12531HMPREF0733_11108flavodoxin-like protein
Saccharothrix espanaensis15066BN6_12620NAD(P)H dehydrogenase (quinone)
BN6_62130NAD(P)H dehydrogenase (quinone)
Serratia odorifera102598HMPREF0758_3629NAD(P)H dehydrogenase (quinone)
Shimwellia blattae105725EB105725_21_00430FMN-dependent NADH-azoreductase
EB105725_21_00570FMN-dependent NADH-azoreductase
EB105725_26_00280FMN-dependent NADH-azoreductase
Sphingobium sp.103272SLG_06410FMN-dependent NADH-azoreductase
Sphingomonas wittichii105917Swit_2250NAD(P)H dehydrogenase (quinone)
Swit_2282NAD(P)H dehydrogenase (quinone)
Sporichthya polymorpha12702Spopo_31_08700FMN-dependent NADH-azoreductase
Stackebrandtia nassauensis102104Snas_1651NAD(P)H dehydrogenase (quinone)
Snas_2531NAD(P)H dehydrogenase (quinone)
Starkeya novella14993Snov_2532NAD(P)H dehydrogenase (quinone)
Streptomyces avermitilis14893SAV4344hypothetical protein
Streptomyces cattleya14057SCAT_3080FMN-dependent NADH-azoreductase
Streptosporangium roseum3776Sros_4014acyl carrier protein phosphodiesterase
Sros_5333Acyl carrier protein phosphodiesterase-like protein
Sros_5486(acyl-carrier-protein) phosphodiesterase
Thauera linaloolentis102519C666_00305NAD(P)H dehydrogenase (quinone)
Thermomonospora curvata15933Tcur_2797NAD(P)H dehydrogenase (quinone)
Vibrio alginolyticus15630N646_0512FMN-dependent NADH-azoreductase
Vibrio tubiashii15644VITU9109_15218azoreductase
Vibrio vulnificus15645B736_12630FMN-dependent NADH-azoreductase
Yersinia bercovieri105717yberc0001_22940FMN-dependent NADH-azoreductase
Yersinia rohdei105715yrohd0001_26810FMN-dependent NADH-azoreductase