| accession | DB | alignment | Evalue | Score | Ident. | link | information | pubmed |
1
|
Q56173_STRVN (Q56173) |
|
|
0.0 |
653 |
100% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- graE
gra-orf17
- Organism
- Streptomyces violaceoruber
|
1uniprot[Pubmed] 7476861 [Medline] 96027933 Identification of Streptomyces violaceoruber Tu22 genes involved in the biosynthesis of granaticin.(Mol. Gen. Genet.) [1995] | 2uniprot[Pubmed] 2583128 [Medline] 90060034 Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber Tu22.(EMBO J.) [1989] | 3uniprot[Pubmed] 9831526 [Medline] 99051446 The granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tu22: sequence analysis and expression in a heterologous host.(Chem. Biol.) [1998] | [pubmed all]
|
3
|
Q2PZR3_9ACTO (Q2PZR3) |
|
|
1e-124 |
448 |
69% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- cosH
- Organism
- Streptomyces olindensis
|
1uniprot[Pubmed] 16810496 Insights in the glycosylation steps during biosynthesis of the antitumor anthracycline cosmomycin: characterization of two glycosyltransferase genes.(Appl. Microbiol. Biotechnol.) [2006] |
|
4
|
Q2HR54_9ACTO (Q2HR54) |
|
|
1e-122 |
442 |
67% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- schS5
- Organism
- Streptomyces sp. SCC 2136
|
1uniprot Angucyclines Sch 47554 and Sch 47555 from Streptomyces sp. SCC-2136: Cloning, Sequencing, and Characterization.(Mol. Cells) [2006] | 2uniprot Molecular cloning and characterization of biosynthetic genes cluster of Sch 47554 from Streptomyces sp. SCC 2136. [2004] |
|
5
|
B8Y4F0_STRAU (B8Y4F0) |
|
|
1e-122 |
442 |
69% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- aur1T
- Organism
- Streptomyces aureofaciens
|
1uniprot[Pubmed] 20490753 Identification and characterization of an indigoidine-like gene for a blue pigment biosynthesis in Streptomyces aureofaciens CCM 3239.(Folia Microbiol. (Praha)) [2010] |
|
7
|
F2RC33_STRVP (F2RC33) |
|
|
1e-121 |
438 |
69% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- SVEN_5998
- Organism
- Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
|
1uniprot[Pubmed] 21463507 Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes.(BMC Genomics) [2011] |
|
8
|
Q9ZGC7_STRCY (Q9ZGC7) |
|
|
1e-121 |
437 |
67% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- lanH14
- Organism
- Streptomyces cyanogenus
|
1uniprot[Pubmed] 9933932 [Medline] 99132695 Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin biosynthesis.(FEMS Microbiol. Lett.) [1999] |
|
9
|
C4NYL8_9ACTO (C4NYL8) |
|
|
1e-120 |
437 |
66% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- saqH
- Organism
- Micromonospora sp. Tu 6368
|
1uniprot[Pubmed] 17497146 A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007] | 2uniprot[Pubmed] 19384899 Cloning and sequencing of the biosynthetic gene cluster for saquayamycin z and galtamycin B and the elucidation of the assembly of their saccharide chains.(Chembiochem) [2009] | [pubmed all]
|
10
|
Q9RPA5_STRFR (Q9RPA5) |
|
|
1e-120 |
435 |
66% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- urdH
- Organism
- Streptomyces fradiae
Streptomyces roseoflavus
|
1uniprot[Pubmed] 10658661 [Medline] 20121748 Two new tailoring enzymes, a glycosyltransferase and an oxygenase, involved in biosynthesis of the angucycline antibiotic urdamycin A in Streptomyces fradiae Tu2717.(Microbiology) [2000] |
|
12
|
D1A6U0_THECD (D1A6U0) |
|
|
1e-118 |
428 |
66% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- Tcur_2799
- Organism
- Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
|
1uniprot Complete genome sequence of Thermomonospora curvata type strain (B9).(Stand. Genomic Sci.) [2011] |
|
13
|
D7BZT0_STRBB (D7BZT0) |
|
|
1e-117 |
427 |
67% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- SBI_06865
- Organism
- Streptomyces bingchenggensis (strain BCW-1)
|
1uniprot[Pubmed] 20581206 Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010] |
|
15
|
B1VRP9_STRGG (B1VRP9) |
|
|
1e-117 |
425 |
64% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- SGR_638
- Organism
- Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
|
1uniprot[Pubmed] 18375553 Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350.(J. Bacteriol.) [2008] |
|
17
|
B5GLJ1_STRCL (B5GLJ1) |
|
|
1e-117 |
425 |
66% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- SCLAV_p1371
SSCG_00215
- Organism
- Streptomyces clavuligerus ATCC 27064
|
1uniprot The sequence of a 1.8 Mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.(Genome Biol. Evol.) [2010] |
|
18
|
Q9L4U7_9ACTO (Q9L4U7) |
|
|
1e-116 |
424 |
68% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- aknR
- Organism
- Streptomyces galilaeus
|
1uniprot[Pubmed] 11016846 [Medline] 20469061 A gene cluster from Streptomyces galilaeus involved in glycosylation of aclarubicin.(Mol. Gen. Genet.) [2000] |
|
19
|
B0LJ31_9ACTO (B0LJ31) |
|
|
1e-115 |
421 |
67% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- lct48
- Organism
- Streptomyces rishiriensis
|
1uniprot[Pubmed] 18070976 Biosynthetic investigations of lactonamycin and lactonamycin z: cloning of the biosynthetic gene clusters and discovery of an unusual starter unit.(Antimicrob. Agents Chemother.) [2008] |
|
20
|
Q2PC88_STRAH (Q2PC88) |
|
|
1e-115 |
420 |
68% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- rubN2
- Organism
- Streptomyces achromogenes subsp. rubradiris
|
1uniprot[Pubmed] 9387157 [Medline] 98048398 Identification of a gene cluster of biosynthetic genes of rubradirin substructures in S. achromogenes var. rubradiris NRRL3061.(Mol. Cells) [1997] | 2uniprot[Pubmed] 12889805 [Medline] 22771458 Functional identification of rub52 gene involved in the biosynthesis of rubradirin.(Biotechnol. Lett.) [2003] | [pubmed all]
|
21
|
Q7WT24_9ACTO (Q7WT24) |
|
|
1e-115 |
419 |
64% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- med-ORF17
- Organism
- Streptomyces sp. AM-7161
|
1uniprot Cloning, sequencing and heterologous expression of the medermycin biosynthetic gene cluster of Streptomyces sp. AM-7161: towards comparative analysis of the benzoisochromanequione gene clusters.(Microbiology (Mosc.)) [2003] |
|
24
|
D7RFL0_AMYOR (D7RFL0) |
|
|
1e-110 |
404 |
66% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- bexS
- Organism
- Amycolatopsis orientalis subsp. vinearia
|
1uniprot[Pubmed] 20443562 A biosynthetic pathway for BE-7585A, a 2-thiosugar-containing angucycline-type natural product.(J. Am. Chem. Soc.) [2010] |
|
25
|
D9I0H4_9ACTO (D9I0H4) |
|
|
1e-110 |
402 |
62% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- cpzDIII
- Organism
- Streptomyces sp. MK730-62F2
|
1uniprot[Pubmed] 20418426 Formation and attachment of the deoxysugar moiety and assembly of the gene cluster for caprazamycin biosynthesis.(Appl. Environ. Microbiol.) [2010] |
|
26
|
E9L1H3_9ZZZZ (E9L1H3) |
|
|
1e-110 |
401 |
63% |
|
- Product
- Putative uncharacterized protein
- Gene
- CA37-29
- Organism
- uncultured organism CA37
|
1uniprot[Pubmed] 20945895 Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010] |
|
27
|
Q9F5R6_STRSD (Q9F5R6) |
|
|
1e-109 |
399 |
62% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
-
- Organism
- Streptomyces sp. (strain ATCC 17920 / DSM 40477 / NCIB 11028)
Streptomyces tenebrarius
|
1uniprot[Pubmed] 11517612 [Medline] 21409420 Cloning of the sugar related biosynthesis gene cluster from Streptomyces tenebrarius H6(Sheng Wu Gong Cheng Xue Bao) [2001] |
|
30
|
Q0R4N2_STRAT (Q0R4N2) |
|
|
1e-108 |
397 |
64% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
-
- Organism
- Streptomyces antibioticus
|
1uniprot[Pubmed] 16793515 Genetic characterization of the chlorothricin gene cluster as a model for spirotetronate antibiotic biosynthesis.(Chem. Biol.) [2006] |
|
31
|
C6WJ73_ACTMD (C6WJ73) |
|
|
1e-108 |
397 |
61% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- Amir_6347
- Organism
- Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971)
|
1uniprot Complete genome sequence of Actinosynnema mirum type strain (101).(Stand. Genomic Sci.) [2009] |
|
33
|
C0JWC1_9ACTO (C0JWC1) |
|
|
1e-108 |
395 |
62% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- pokS2
- Organism
- Streptomyces diastatochromogenes
|
1uniprot[Pubmed] 19266534 Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009] |
|
34
|
A0ACJ2_STRAM (A0ACJ2) |
|
|
1e-108 |
395 |
61% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- SAMR0486
- Organism
- Streptomyces ambofaciens ATCC 23877
|
1uniprot[Pubmed] 16956972 Evolution of the terminal regions of the Streptomyces linear chromosome.(Mol. Biol. Evol.) [2006] | 2uniprot Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877.(Microbiology (Mosc.)) [2006] |
|
35
|
D8I3S0_AMYMU (D8I3S0) |
|
|
1e-108 |
395 |
62% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- rfbB
AMED_1007
- Organism
- Amycolatopsis mediterranei (strain U-32)
|
1uniprot[Pubmed] 20567260 Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010] |
|
36
|
A0ADF0_STRAM (A0ADF0) |
|
|
1e-108 |
395 |
65% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- SAMR0797
- Organism
- Streptomyces ambofaciens ATCC 23877
|
1uniprot[Pubmed] 16956972 Evolution of the terminal regions of the Streptomyces linear chromosome.(Mol. Biol. Evol.) [2006] | 2uniprot Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877.(Microbiology (Mosc.)) [2006] |
|
37
|
Q2I756_9ACTO (Q2I756) |
|
|
1e-108 |
395 |
65% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- plaA3
STTU_1455
- Organism
- Streptomyces sp. Tu6071
|
1uniprot[Pubmed] 16632249 Biosynthesis of the terpene phenalinolactone in Streptomyces sp. Tu6071: analysis of the gene cluster and generation of derivatives.(Chem. Biol.) [2006] |
|
38
|
Q9ZGH3_9ACTO (Q9ZGH3) |
|
|
1e-107 |
393 |
64% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- desIV
- Organism
- Streptomyces venezuelae
|
1uniprot[Pubmed] 9770448 [Medline] 98445333 A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity.(Proc. Natl. Acad. Sci. U.S.A.) [1998] | 2uniprot[Pubmed] 14570895 High resolution X-ray structure of dTDP-glucose 4,6-dehydratase from Streptomyces venezuelae.(J. Biol. Chem.) [2004] | [pubmed all]
|
39
|
Q83X80_STRRO (Q83X80) |
|
|
1e-107 |
392 |
64% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- lkmD
- Organism
- Streptomyces rochei
Streptomyces parvullus
|
1uniprot[Pubmed] 12791134 [Medline] 22676866 The large linear plasmid pSLA2-L of Streptomyces rochei has an unusually condensed gene organization for secondary metabolism.(Mol. Microbiol.) [2003] | 2uniprot[Pubmed] 10954087 [Medline] 20408175 Cloning and analysis of the replication origin and the telomeres of the large linear plasmid pSLA2-L in Streptomyces rochei.(Mol. Gen. Genet.) [2000] | 3uniprot[Pubmed] 10767533 [Medline] 20231737 Identification of two polyketide synthase gene clusters on the linear plasmid pSLA2-L in Streptomyces rochei.(Gene) [2000] | 4uniprot[Pubmed] 9836424 [Medline] 99053144 Physical mapping of the linear plasmid pSLA2-L and localization of the eryAI and actI homologs.(Biosci. Biotechnol. Biochem.) [1998] | [pubmed all]
|
40
|
Q939Q5_9ACTO (Q939Q5) |
|
|
1e-107 |
392 |
65% |
|
- Product
- NDP-hexose 4,6-dehydratase
- Gene
- jadT
- Organism
- Streptomyces venezuelae
|
1uniprot[Pubmed] 11932454 [Medline] 21930291 Biosynthesis of the dideoxysugar component of jadomycin B: genes in the jad cluster of Streptomyces venezuelae ISP5230 for L-digitoxose assembly and transfer to the angucycline aglycone.(Microbiology) [2002] |
|
42
|
Q9S0P5_STRAW (Q9S0P5) |
|
|
1e-106 |
391 |
63% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- aveBII
SAV946 SAV_946
- Organism
- Streptomyces avermitilis
|
1uniprot[Pubmed] 10449723 [Medline] 99380548 Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis.(Proc. Natl. Acad. Sci. U.S.A.) [1999] | 2uniprot[Pubmed] 11572948 [Medline] 21477403 Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.(Proc. Natl. Acad. Sci. U.S.A.) [2001] | 3uniprot[Pubmed] 12692562 [Medline] 22608306 Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis.(Nat. Biotechnol.) [2003] | [pubmed all]
|
43
|
Q5SFD3_STRBI (Q5SFD3) |
|
|
1e-106 |
390 |
61% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- chmAII
- Organism
- Streptomyces bikiniensis
|
1uniprot[Pubmed] 15561847 Chalcomycin biosynthesis gene cluster from Streptomyces bikiniensis: novel features of an unusual ketolide produced through expression of the chm polyketide synthase in Streptomyces fradiae.(Antimicrob. Agents Chemother.) [2004] |
|
44
|
D2B1Y0_STRRD (D2B1Y0) |
|
|
1e-106 |
389 |
61% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- Sros_6490
- Organism
- Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
|
1uniprot Complete genome sequence of Streptosporangium roseum type strain (NI 9100T).(Stand. Genomic Sci.) [2010] |
|
45
|
Q76KZ7_STRHA (Q76KZ7) |
|
|
1e-106 |
389 |
61% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- vinB
- Organism
- Streptomyces halstedii
|
1uniprot[Pubmed] 15112997 Cloning, sequencing, and functional analysis of the biosynthetic gene cluster of macrolactam antibiotic vicenistatin in Streptomyces halstedii.(Chem. Biol.) [2004] |
|
46
|
C7MUW7_SACVD (C7MUW7) |
|
|
1e-106 |
388 |
61% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- Svir_06090
- Organism
- Saccharomonospora viridis (strain ATCC 15386 / DSM 43017 / JCM 3036 / NBRC 12207 / P101)
|
1uniprot Complete genome sequence of Saccharomonospora viridis type strain (P101T).(Stand. Genomic Sci.) [2009] |
|
47
|
D9UBQ9_STRPR (D9UBQ9) |
|
|
1e-105 |
387 |
62% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- cpp25
- Organism
- Streptomyces pristinaespiralis
|
1uniprot[Pubmed] 21342465 Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011] |
|
49
|
Q331R3_9ACTO (Q331R3) |
|
|
1e-105 |
386 |
61% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- gerE
- Organism
- Streptomyces sp. KCTC 0041BP
|
1uniprot[Pubmed] 17053005 Biosynthesis of dTDP-6-deoxy-beta-D-allose, biochemical characterization of dTDP-4-keto-6-deoxyglucose reductase (GerKI) from Streptomyces sp. KCTC 0041BP.(Glycobiology) [2007] | 2uniprot Cloning and characterization of a gene cluster for the production of the polyketide macrolide antibiotic dihydrochalcomycin in Streptomyces sp. KCTC 0041BP.(J. Microbiol. Biotechnol.) [2006] |
|
50
|
B5L6K3_MICCH (B5L6K3) |
|
|
1e-105 |
385 |
60% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
-
- Organism
- Micromonospora chalcea
|
1uniprot[Pubmed] 18586939 Cloning and characterization of the tetrocarcin A gene cluster from Micromonospora chalcea NRRL 11289 reveals a highly conserved strategy for tetronate biosynthesis in spirotetronate antibiotics.(J. Bacteriol.) [2008] |
|
51
|
B3TMR2_9ACTO (B3TMR2) |
|
|
1e-105 |
385 |
58% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- KijD4
- Organism
- Actinomadura kijaniata
|
1uniprot[Pubmed] 17985890 Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007] |
|
54
|
Q93EK0_9PSEU (Q93EK0) |
|
|
1e-104 |
384 |
60% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- gdh
- Organism
- Saccharopolyspora spinosa
|
1uniprot[Pubmed] 11544225 [Medline] 21429236 Rhamnose biosynthesis pathway supplies precursors for primary and secondary metabolism in Saccharopolyspora spinosa.(J. Bacteriol.) [2001] |
|
57
|
Q7WTE5_9ACTO (Q7WTE5) |
|
|
1e-104 |
383 |
62% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- nanG2
- Organism
- Streptomyces nanchangensis
|
1uniprot[Pubmed] 12770825 [Medline] 22654646 A complete gene cluster from Streptomyces nanchangensis NS3226 encoding biosynthesis of the polyether ionophore nanchangmycin.(Chem. Biol.) [2003] |
|
61
|
Q9RJE3_STRCO (Q9RJE3) |
|
|
1e-104 |
381 |
63% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- SCO0749
- Organism
- Streptomyces coelicolor
|
1uniprot[Pubmed] 12000953 [Medline] 21996410 Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).(Nature) [2002] |
|
65
|
Q3S887_9ACTO (Q3S887) |
|
|
1e-103 |
380 |
63% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
-
- Organism
- Streptomyces neyagawaensis
|
1uniprot[Pubmed] 16207901 Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449.(Microbiology) [2005] |
|
68
|
D7BSN0_STRBB (D7BSN0) |
|
|
1e-103 |
380 |
62% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- nanG2
SBI_08409
- Organism
- Streptomyces bingchenggensis (strain BCW-1)
|
1uniprot[Pubmed] 20581206 Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010] |
|
69
|
C7G1T6_STRGR (C7G1T6) |
|
|
1e-103 |
379 |
60% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
-
- Organism
- Streptomyces griseus
|
1uniprot Identification of the biosynthetic gene cluster of A-500359s in Streptomyces griseus SANK60196.(J. Antibiot.) [2009] |
|
70
|
Q52V54_9ACTO (Q52V54) |
|
|
1e-103 |
379 |
61% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
-
- Organism
- Streptomyces aizunensis
|
1uniprot[Pubmed] 15844935 Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example.(J. Nat. Prod.) [2005] |
|
71
|
Q83WD7_MICGR (Q83WD7) |
|
|
1e-103 |
378 |
60% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- mydB
- Organism
- Micromonospora griseorubida
|
1uniprot[Pubmed] 12583909 [Medline] 22472038 Organization of the biosynthetic gene cluster for the polyketide macrolide mycinamicin in Micromonospora griseorubida.(FEMS Microbiol. Lett.) [2003] |
|
73
|
C9YYJ5_STRSW (C9YYJ5) |
|
|
1e-102 |
377 |
62% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- SCAB_84041
- Organism
- Streptomyces scabies (strain 87.22)
Streptomyces scabiei
|
1uniprot[Pubmed] 20064060 Streptomyces scabies 87-22 contains a coronafacic acid-like biosynthetic cluster that contributes to plant-microbe interactions.(Mol. Plant Microbe Interact.) [2010] |
|
75
|
D2B4G9_STRRD (D2B4G9) |
|
|
1e-102 |
377 |
60% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- Sros_0632
- Organism
- Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
|
1uniprot Complete genome sequence of Streptosporangium roseum type strain (NI 9100T).(Stand. Genomic Sci.) [2010] |
|
77
|
B1W376_STRGG (B1W376) |
|
|
1e-102 |
376 |
62% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- strE
SGR_5929
- Organism
- Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
|
1uniprot[Pubmed] 18375553 Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350.(J. Bacteriol.) [2008] |
|
79
|
E4NCQ6_KITSK (E4NCQ6) |
|
|
1e-102 |
375 |
59% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- rmlB1
KSE_31770
- Organism
- Kitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054)
Streptomyces setae
|
1uniprot[Pubmed] 21059706 Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary snapshot of the family Streptomycetaceae.(DNA Res.) [2010] |
|
80
|
Q194R3_STRAA (Q194R3) |
|
|
1e-102 |
375 |
61% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- mtmE
- Organism
- Streptomyces argillaceus
|
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996] | 2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996] | 3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997] | 4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998] | 5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999] | 6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999] | 7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000] | 8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001] | 9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003] | 10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999] | 11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002] | 12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000] | 13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000] | 14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002] | 15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003] | 16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996] | 17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004] | 18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997] | 19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005] | 20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000] | [pubmed all]
|
81
|
E5F142_9ACTO (E5F142) |
|
|
1e-102 |
375 |
58% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- rmlB
- Organism
- Kitasatospora kifunensis
|
1uniprot[Pubmed] 20667525 Cloning and in vitro characterization of dTDP-6-deoxy-L-talose biosynthetic genes from Kitasatospora kifunensis featuring the dTDP-6-deoxy-L-lyxo-4-hexulose reductase that synthesizes dTDP-6-deoxy-L-talose.(Carbohydr. Res.) [2010] |
|
84
|
A8WEY5_STRST (A8WEY5) |
|
|
1e-101 |
374 |
58% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- spcE
- Organism
- Streptomyces spectabilis
|
1uniprot[Pubmed] 10650224 [Medline] 20117819 An efficient approach for cloning the dNDP-glucose synthase gene from actinomycetes and its application in Streptomyces spectabilis, a spectinomycin producer.(FEMS Microbiol. Lett.) [2000] | 2uniprot[Pubmed] 18663525 The Gene Cluster for Spectinomycin Biosynthesis and the Aminoglycoside-Resistance Function of spcM in Streptomyces spectabilis.(Curr. Microbiol.) [2008] | [pubmed all]
|
88
|
F4F6Y4_VERMA (F4F6Y4) |
|
|
1e-101 |
373 |
60% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- VAB18032_22795
- Organism
- Verrucosispora maris (strain AB-18-032)
|
1uniprot[Pubmed] 21551311 Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.(J. Bacteriol.) [2011] |
|
92
|
A4FNM4_SACEN (A4FNM4) |
|
|
1e-101 |
371 |
57% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- aveBII
SACE_6480
- Organism
- Saccharopolyspora erythraea (strain NRRL 23338)
|
1uniprot[Pubmed] 17369815 Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007] |
|
93
|
Q54116_SACER (Q54116) |
|
|
1e-101 |
371 |
57% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- gdh
- Organism
- Saccharopolyspora erythraea
Streptomyces erythraeus
|
1uniprot[Pubmed] 7883182 [Medline] 95189100 Cloning of the genes encoding thymidine diphosphoglucose 4,6-dehydratase and thymidine diphospho-4-keto-6-deoxyglucose 3,5-epimerase from the erythromycin-producing Saccharopolyspora erythraea.(Gene) [1995] |
|
95
|
Q9RMG0_STRGL (Q9RMG0) |
|
|
1e-100 |
371 |
58% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- sgcA
- Organism
- Streptomyces globisporus
|
1uniprot[Pubmed] 10639366 [Medline] 20106985 Genes for production of the enediyne antitumor antibiotic C-1027 in Streptomyces globisporus are clustered with the cagA gene that encodes the C-1027 apoprotein.(Antimicrob. Agents Chemother.) [2000] | 2uniprot[Pubmed] 12183628 [Medline] 22171413 Biosynthesis of the enediyne antitumor antibiotic C-1027.(Science) [2002] | [pubmed all]
|
96
|
Q9RN58_STRNO (Q9RN58) |
|
|
1e-100 |
370 |
61% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- snogK
- Organism
- Streptomyces nogalater
|
1uniprot[Pubmed] 9349712 [Medline] 98007868 Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.(Mol. Gen. Genet.) [1997] | 2uniprot[Pubmed] 10639368 [Medline] 20106987 Identification of a cyclase gene dictating the C-9 stereochemistry of anthracyclines from Streptomyces nogalater.(Antimicrob. Agents Chemother.) [2000] | [pubmed all]
|
97
|
A8KQL1_9ACTO (A8KQL1) |
|
|
1e-100 |
369 |
57% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- rhaB
- Organism
- Streptomyces olivaceus
|
1uniprot[Pubmed] 18310024 Biosynthesis of elloramycin in Streptomyces olivaceus requires glycosylation by enzymes encoded outside the aglycon cluster.(Microbiology) [2008] |
|
99
|
E4N8V2_KITSK (E4N8V2) |
|
|
1e-100 |
368 |
60% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- rmlB2
KSE_18080
- Organism
- Kitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054)
Streptomyces setae
|
1uniprot[Pubmed] 21059706 Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary snapshot of the family Streptomycetaceae.(DNA Res.) [2010] |
|
100
|
D6MSX9_9ACTO (D6MSX9) |
|
|
2e-99 |
366 |
60% |
|
- Product
- dTDP-glucose 4,6-dehydratase
- Gene
- ssfS2
- Organism
- Streptomyces sp. SF2575
|
1uniprot[Pubmed] 19908837 Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.(J. Am. Chem. Soc.) [2009] |
|