BLAST table : Grana_00290

DBUniProtKB
accessionDBalignmentEvalueScoreIdent.linkproductgeneorganismec
1
 CYPK_STRVN
(P16560)		 
[query] 1 - 324 (324)
[subject] 1 - 324 (324)
 0.0 645   100% Granaticin polyketide synthase bifunctional cyclase/dehydratase gra-orf4 Streptomyces violaceoruber
2
 E3T4B3_9ACTO
(E3T4B3)		 
[query] 10 - 321 (324)
[subject] 6 - 316 (328)
 1e-151 538   87% Aromatase gra-orf4 Streptomyces vietnamensis
3
 D3U1V0_9BACT
(D3U1V0)		 
[query] 15 - 322 (324)
[subject] 3 - 309 (316)
 1e-108 395   64% Aromatase uncultured soil bacterium V167
4
 Q9FCM5_STRAT
(Q9FCM5)		 
[query] 16 - 318 (324)
[subject] 6 - 307 (318)
 1e-105 385   63% Putative aromatase Streptomyces antibioticus
5
 Q9X464_STRAE
(Q9X464)		 Jump to Naphcy_00040 
[query] 19 - 318 (324)
[subject] 10 - 308 (315)
 6e-94 348   61% Aromatase ncnD Streptomyces arenae
6
 Q2J5J6_FRASC
(Q2J5J6)		 
[query] 14 - 318 (324)
[subject] 2 - 307 (319)
 7e-80 301   51% Actinorhodin polyketide synthase bifunctional cyclase/dehydratase Francci3_4098 Frankia sp. (strain CcI3)
7
 Q935Z5_9ACTO
(Q935Z5)		 
[query] 11 - 323 (324)
[subject] 1 - 310 (452)
 7e-75 285   49% RdmK rdmK Streptomyces purpurascens
8
 E3J3Q0_FRASU
(E3J3Q0)		 
[query] 17 - 315 (324)
[subject] 16 - 321 (341)
 6e-73 278   50% Polyketide cyclase/dehydrase FraEuI1c_1320 Frankia sp. (strain EuI1c)
9
 Q84CH8_9ACTO
(Q84CH8)		 
[query] 20 - 322 (324)
[subject] 10 - 311 (314)
 3e-72 276   47% Cyclase-like protein pd2D Streptomyces sp. WP 4669
10
 Q93LY0_9ACTO
(Q93LY0)		 
[query] 20 - 322 (324)
[subject] 10 - 311 (314)
 5e-72 276   46% Putative bifunctional aromatase PgaL pgaL Streptomyces sp. PGA64
11
 CYPK_STRCO
(Q02055)		 Jump to Actino_00210 
[query] 11 - 316 (324)
[subject] 1 - 307 (316)
 6e-72 275   51% Actinorhodin polyketide synthase bifunctional cyclase/dehydratase
ACTVII
actI ORF4		 SCO5090
SCBAC28G1.16		 Streptomyces coelicolor
12
 Q54221_STRGR
(Q54221)		 Jump to Griseu_00050 
[query] 11 - 322 (324)
[subject] 1 - 311 (319)
 2e-71 273   45% Putative cyclase/dehydrase Streptomyces griseus
13
 D6EWA4_STRLI
(D6EWA4)		 
[query] 11 - 316 (324)
[subject] 1 - 307 (316)
 2e-71 273   51% Cyclase/dehydrase SSPG_02599 Streptomyces lividans TK24
14
 D1XRF3_9ACTO
(D1XRF3)		 
[query] 20 - 322 (324)
[subject] 10 - 311 (314)
 5e-71 272   47% Cyclase/dehydrase SACTEDRAFT_5263 Streptomyces sp. SA3_actE
15
 D9W5A6_9ACTO
(D9W5A6)		 
[query] 11 - 323 (324)
[subject] 1 - 312 (314)
 7e-71 272   43% Aur1H SSNG_07336 Streptomyces sp. C
16
 C4NYK3_9ACTO
(C4NYK3)		 
[query] 20 - 323 (324)
[subject] 10 - 312 (314)
 3e-70 270   47% SaqL saqL Micromonospora sp. Tu 6368
17
 Q84CJ3_9ACTO
(Q84CJ3)		 
[query] 15 - 322 (324)
[subject] 2 - 308 (311)
 4e-70 270   44% Cyclase/dehydratase-like protein kinD Streptomyces murayamaensis
18
 Q2HR24_9ACTO
(Q2HR24)		 Jump to Sch475_00340 
[query] 15 - 322 (324)
[subject] 2 - 309 (312)
 6e-70 269   45% Putative aromatase schP4 Streptomyces sp. SCC 2136
19
 Q6ZZV8_STRAT
(Q6ZZV8)		 Jump to Ovied_00150 
[query] 15 - 322 (324)
[subject] 2 - 308 (315)
 7e-70 268   45% Aromatase ovmA Streptomyces antibioticus
20
 Q9RPB1_STRFR
(Q9RPB1)		 Jump to Urd_00160 
[query] 15 - 323 (324)
[subject] 2 - 309 (311)
 9e-70 268   45% Cyclase urdL Streptomyces fradiae
Streptomyces roseoflavus
21
 Q47QK9_THEFY
(Q47QK9)		 
[query] 14 - 314 (324)
[subject] 3 - 303 (314)
 6e-69 265   45% Actinorhodin polyketide synthase bifunctional cyclase/dehydratase Tfu_1222 Thermobifida fusca (strain YX)
22
 Q2J5F1_FRASC
(Q2J5F1)		 
[query] 20 - 324 (324)
[subject] 13 - 316 (318)
 6e-69 265   47% Actinorhodin polyketide synthase bifunctional cyclase/dehydratase Francci3_4143 Frankia sp. (strain CcI3)
23
 D2XDY3_9PSEU
(D2XDY3)		 
[query] 11 - 323 (324)
[subject] 1 - 314 (316)
 2e-68 264   43% AzicE azicE Kibdelosporangium sp. MJ126-NF4
24
 D5MRI9_9ACTO
(D5MRI9)		 
[query] 15 - 322 (324)
[subject] 2 - 308 (311)
 2e-67 260   45% Putative aromatase hrbP Streptomyces sp. 2238-SVT4
25
 Q9AMI9_STRAT
(Q9AMI9)		 
[query] 20 - 323 (324)
[subject] 10 - 313 (315)
 2e-67 260   46% Putative cyclase/dehydrase SimA5
Sim6		 simA5
sim6		 Streptomyces antibioticus
26
 Q7WT27_9ACTO
(Q7WT27)		 Jump to Medem_00150 
[query] 11 - 321 (324)
[subject] 1 - 314 (318)
 5e-67 259   46% First ring aromatase (ARO) med-ORF19 Streptomyces sp. AM-7161
27
 D6MSV2_9ACTO
(D6MSV2)		 
[query] 19 - 317 (324)
[subject] 9 - 307 (314)
 6e-67 259   46% SsfY1 ssfY1 Streptomyces sp. SF2575
28
 F2RC19_STRVP
(F2RC19)		 
[query] 15 - 322 (324)
[subject] 2 - 308 (311)
 1e-66 258   45% Bifunctional cyclase or dehydrase SVEN_5984 Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
29
 Q93M00_STRAU
(Q93M00)		 
[query] 11 - 324 (324)
[subject] 1 - 314 (316)
 1e-66 258   43% Cyclase/dehydratase-like protein aur2F Streptomyces aureofaciens
30
 D9UBK6_STRPR
(D9UBK6)		 
[query] 16 - 324 (324)
[subject] 6 - 314 (318)
 1e-66 258   45% Putative cyclase c104_07c Streptomyces pristinaespiralis
31
 B5HJY1_STRPR
(B5HJY1)		 
[query] 16 - 324 (324)
[subject] 6 - 314 (318)
 1e-66 258   45% Cyclase SSDG_05478 Streptomyces pristinaespiralis ATCC 25486
32
 Q9ZGD3_STRCY
(Q9ZGD3)		 Jump to Lando_00070 
[query] 15 - 323 (324)
[subject] 2 - 316 (319)
 2e-66 257   44% Cyclase homolog lanL Streptomyces cyanogenus
33
 Q54490_STRNO
(Q54490)		 Jump to Nogl_00320 
[query] 15 - 322 (324)
[subject] 9 - 317 (323)
 4e-66 256   46% SnoaE snoaE Streptomyces nogalater
34
 F6K0W1_9BACT
(F6K0W1)		 
[query] 11 - 322 (324)
[subject] 1 - 311 (316)
 5e-66 256   44% Aromatase uncultured bacterium BAC AB649/1850
35
 D1H099_9ACTO
(D1H099)		 
[query] 11 - 317 (324)
[subject] 1 - 305 (314)
 5e-66 256   46% Putative bifunctional cyclase/dehydratase chryK Streptomyces albaduncus
36
 Q4R0M7_STRCX
(Q4R0M7)		 Jump to Chart_00050 
[query] 11 - 322 (324)
[subject] 1 - 310 (322)
 5e-66 256   45% ChaF protein chaF Streptomyces chartreusis
37
 D9T2A8_MICAI
(D9T2A8)		 
[query] 19 - 324 (324)
[subject] 6 - 307 (310)
 2e-65 253   48% Polyketide cyclase/dehydrase Micau_4011 Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
38
 E8RWS1_MICSL
(E8RWS1)		 
[query] 19 - 324 (324)
[subject] 6 - 307 (310)
 2e-65 253   48% Polyketide cyclase/dehydrase ML5_4410 Micromonospora sp. (strain L5)
39
 Q56H98_STRAU
(Q56H98)		 
[query] 11 - 322 (324)
[subject] 1 - 311 (320)
 3e-65 253   42% Aur1H aur1H Streptomyces aureofaciens
40
 A1C174_9ACTO
(A1C174)		 Jump to Aran_00060 
[query] 17 - 322 (324)
[subject] 5 - 309 (314)
 4e-65 253   45% Cyclase Streptomyces echinatus
41
 E8W959_STRFA
(E8W959)		 
[query] 21 - 322 (324)
[subject] 40 - 342 (347)
 1e-64 251   47% Polyketide cyclase/dehydrase Sfla_5325 Streptomyces flavogriseus (strain ATCC 33331 / DSM 40990 / IAF-45CD)
42
 Q9L554_9ACTO
(Q9L554)		 Jump to Acla_00040 
[query] 16 - 323 (324)
[subject] 5 - 310 (450)
 3e-64 249   46% AknE1 aknE1 Streptomyces galilaeus
43
 D1H0K2_9ACTO
(D1H0K2)		 
[query] 11 - 317 (324)
[subject] 1 - 307 (315)
 4e-64 249   45% Putative aromatase/cyclase ravK Streptomyces sp. C23201NS3
44
 Q8VWB6_9ACTO
(Q8VWB6)		 
[query] 16 - 322 (324)
[subject] 5 - 309 (450)
 1e-63 248   46% AknE1 aknE1 Streptomyces galilaeus
45
 Q6VMJ1_STRAM
(Q6VMJ1)		 
[query] 15 - 323 (324)
[subject] 2 - 311 (314)
 1e-63 248   43% Putative bifunctional cyclase/dehydrase
Putative cyclase/dehydratase		 alpE
DSMT0181		 Streptomyces ambofaciens
46
 Q1RQS4_STRAM
(Q1RQS4)		 
[query] 15 - 323 (324)
[subject] 2 - 311 (314)
 1e-63 248   43% Putative cyclase/dehydratase alpE
SAMT0161
SAMT0162		 Streptomyces ambofaciens ATCC 23877
47
 Q56167_9ACTO
(Q56167)		 Jump to Jado_00120 
[query] 15 - 322 (324)
[subject] 2 - 307 (310)
 2e-63 247   44% Bifunctional cyclase/dehydrase Streptomyces venezuelae
48
 B5G889_9ACTO
(B5G889)		 
[query] 17 - 323 (324)
[subject] 6 - 310 (450)
 2e-63 247   48% Granaticin polyketide synthase bifunctional cyclase/dehydratase SSBG_00497 Streptomyces sp. SPB74
49
 C7QAF6_CATAD
(C7QAF6)		 
[query] 16 - 322 (324)
[subject] 6 - 312 (316)
 3e-63 246   42% Cyclase/dehydrase Caci_3550 Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
50
 D6XAX1_9ACTO
(D6XAX1)		 
[query] 21 - 282 (324)
[subject] 13 - 273 (391)
 9e-63 245   48% Cyclase SSEG_11170 Streptomyces sviceus ATCC 29083
51
 D7BZR8_STRBB
(D7BZR8)		 
[query] 21 - 316 (324)
[subject] 11 - 312 (324)
 4e-62 243   43% Actinorhodin polyketide synthase bifunctional cyclase/dehydratase SBI_06853 Streptomyces bingchenggensis (strain BCW-1)
52
 A4X6Z8_SALTO
(A4X6Z8)		 
[query] 11 - 324 (324)
[subject] 1 - 312 (319)
 1e-61 241   45% Cyclase/dehydrase Strop_2197 Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
53
 D7RFJ9_AMYOR
(D7RFJ9)		 
[query] 19 - 322 (324)
[subject] 4 - 306 (309)
 4e-61 239   44% Putative cyclase bexL Amycolatopsis orientalis subsp. vinearia
54
 B6SEF5_9ACTO
(B6SEF5)		 Jump to Alnu_00100 
[query] 13 - 317 (324)
[subject] 12 - 321 (331)
 1e-58 231   45% AlnQ aromatase alnQ Streptomyces sp. CM020
55
 Q9ZG83_STRRM
(Q9ZG83)		 
[query] 11 - 290 (324)
[subject] 1 - 280 (297)
 3e-56 223   43% Cyclase/aromatase otcD1 Streptomyces rimosus
56
 Q54811_STRPE
(Q54811)		 Jump to Adria_00240 
[query] 16 - 322 (324)
[subject] 6 - 312 (315)
 5e-56 222   43% Daunorubicin-doxorubicin polyketide synthase dpsF Streptomyces peucetius
57
 Q3S8Q5_STRRM
(Q3S8Q5)		 Jump to Oxtet_00110 
[query] 11 - 322 (324)
[subject] 1 - 312 (317)
 6e-56 222   44% OxyK oxyK Streptomyces rimosus
58
 Q55220_STRSQ
(Q55220)		 Jump to Dauno_00130 
[query] 16 - 323 (324)
[subject] 6 - 309 (315)
 8e-56 222   43% Cyclase/dehydrase dauA Streptomyces sp
59
 D1A6S1_THECD
(D1A6S1)		 
[query] 21 - 319 (324)
[subject] 30 - 327 (340)
 9e-56 221   43% Cyclase/dehydrase Tcur_2780 Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
60
 Q83X42_STRRO
(Q83X42)		 
[query] 16 - 324 (324)
[subject] 9 - 317 (321)
 2e-55 220   43% Cyclase/aromatase rocH Streptomyces rochei
Streptomyces parvullus
61
 C7PWQ8_CATAD
(C7PWQ8)		 
[query] 18 - 322 (324)
[subject] 17 - 330 (330)
 8e-52 208   43% Actinorhodin polyketide synthase bifunctional cyclase/dehydratase Caci_6488 Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
62
 B7TX46_9ACTO
(B7TX46)		 
[query] 45 - 259 (324)
[subject] 1 - 214 (214)
 2e-51 207   50% Putative cyclase/dehydratase Streptomyces sp. 6G13
63
 D9W5B3_9ACTO
(D9W5B3)		 
[query] 16 - 324 (324)
[subject] 1 - 309 (317)
 5e-50 202   39% Cyclase SSNG_07343 Streptomyces sp. C
64
 Q7X2H2_9ACTO
(Q7X2H2)		 Jump to Gilvo_00220 
[query] 21 - 317 (324)
[subject] 10 - 305 (316)
 1e-49 201   38% Putative cyclase/dehydratase gilK Streptomyces griseoflavus
65
 Q70J63_STRGR
(Q70J63)		 Jump to Chro_00350 
[query] 17 - 322 (324)
[subject] 5 - 310 (318)
 4e-48 196   39% Aromatase cmmQ Streptomyces griseus subsp. griseus
66
 Q54999_9ACTO
(Q54999)		 Jump to Fren_00170 
[query] 19 - 317 (324)
[subject] 14 - 321 (331)
 1e-47 194   41% Aromatase frnQ Streptomyces roseofulvus
67
 D9UKN8_9ACTO
(D9UKN8)		 
[query] 19 - 317 (324)
[subject] 14 - 321 (331)
 7e-47 192   41% Aromatase SSLG_05754 Streptomyces sp. SPB78
68
 Q53669_STRAA
(Q53669)		 Jump to Mith_00120 
[query] 11 - 324 (324)
[subject] 1 - 313 (315)
 3e-45 186   36% Aromatase mtmQ Streptomyces argillaceus
69
 D1XH92_9ACTO
(D1XH92)		 
[query] 13 - 324 (324)
[subject] 2 - 311 (313)
 4e-45 186   38% Cyclase/dehydrase SACTEDRAFT_2143 Streptomyces sp. SA3_actE
70
 CYPK_STRCM
(P41178)		 
[query] 15 - 312 (324)
[subject] 2 - 298 (304)
 2e-44 184   39% Granaticin polyketide synthase bifunctional cyclase/dehydratase
ORF4		 Streptomyces cinnamonensis
71
 D6AAR8_9ACTO
(D6AAR8)		 
[query] 9 - 324 (324)
[subject] 20 - 335 (339)
 2e-44 184   36% Cyclase/aromatase SSFG_07838 Streptomyces ghanaensis ATCC 14672
72
 Q2PA00_9ACTO
(Q2PA00)		 Jump to Stref_00150 
[query] 11 - 322 (324)
[subject] 1 - 304 (309)
 2e-42 177   35% Aromatase stfQ Streptomyces steffisburgensis
73
 Q93HA9_STRAW
(Q93HA9)		 
[query] 13 - 324 (324)
[subject] 11 - 320 (322)
 3e-41 173   36% Aromatase
Putative aromatase		 SAV2383
SAV_2383		 Streptomyces avermitilis
74
 B7TX58_9ACTO
(B7TX58)		 
[query] 45 - 259 (324)
[subject] 1 - 216 (216)
 6e-41 172   45% Putative cyclase/dehydratase Streptomyces sp. MS7-1
75
 B7TX48_9ACTO
(B7TX48)		 
[query] 45 - 259 (324)
[subject] 1 - 216 (216)
 5e-40 169   43% Putative cyclase/dehydratase Streptomyces sp. 6G17
76
 B7TX47_9ACTO
(B7TX47)		 
[query] 45 - 259 (324)
[subject] 1 - 216 (216)
 5e-40 169   43% Putative cyclase/dehydratase Streptomyces sp. 6G8
77
 B7TX45_9ACTO
(B7TX45)		 
[query] 45 - 259 (324)
[subject] 1 - 216 (216)
 1e-39 168   43% Putative cyclase/dehydratase Streptomyces sp. 6G6
78
 B3VP09_9BACT
(B3VP09)		 
[query] 45 - 259 (324)
[subject] 1 - 216 (216)
 3e-39 167   43% Putative cyclase/dehydratase uncultured bacterium
79
 B7TX44_9ACTO
(B7TX44)		 
[query] 45 - 259 (324)
[subject] 1 - 216 (216)
 3e-39 167   42% Putative cyclase/dehydratase Streptomyces sp. 6G6
80
 B3VNZ8_9BACT
(B3VNZ8)		 
[query] 45 - 259 (324)
[subject] 1 - 216 (216)
 3e-39 166   43% Putative cyclase/dehydratase uncultured bacterium
81
 B3VP05_9BACT
(B3VP05)		 
[query] 45 - 259 (324)
[subject] 1 - 216 (216)
 4e-39 166   43% Putative cyclase/dehydratase uncultured bacterium
82
 B3VP06_9BACT
(B3VP06)		 
[query] 45 - 259 (324)
[subject] 1 - 216 (216)
 4e-39 166   42% Putative cyclase/dehydratase uncultured bacterium
83
 B3VNY9_9BACT
(B3VNY9)		 
[query] 45 - 259 (324)
[subject] 1 - 216 (216)
 5e-39 166   42% Putative cyclase/dehydratase uncultured bacterium
84
 B3VP10_9BACT
(B3VP10)		 
[query] 46 - 259 (324)
[subject] 1 - 213 (213)
 6e-39 166   44% Putative cyclase/dehydratase uncultured bacterium
85
 B3VNZ7_9BACT
(B3VNZ7)		 
[query] 45 - 259 (324)
[subject] 1 - 216 (216)
 7e-39 166   43% Putative cyclase/dehydratase uncultured bacterium
86
 B3VNZ1_9BACT
(B3VNZ1)		 
[query] 45 - 259 (324)
[subject] 1 - 216 (216)
 7e-39 166   42% Putative cyclase/dehydratase uncultured bacterium
87
 B3VP00_9BACT
(B3VP00)		 
[query] 45 - 259 (324)
[subject] 1 - 216 (216)
 8e-39 165   42% Putative cyclase/dehydratase uncultured bacterium
88
 B3VP01_9BACT
(B3VP01)		 
[query] 45 - 259 (324)
[subject] 1 - 216 (216)
 9e-39 165   42% Putative cyclase/dehydratase uncultured bacterium
89
 B3VNY7_9ACTO
(B3VNY7)		 
[query] 45 - 259 (324)
[subject] 1 - 216 (216)
 9e-39 165   42% Putative cyclase/dehydratase Streptomyces sp. 4MN1
90
 B3VNZ6_9BACT
(B3VNZ6)		 
[query] 45 - 259 (324)
[subject] 1 - 216 (216)
 1e-38 165   42% Putative cyclase/dehydratase uncultured bacterium
91
 B3VP13_9BACT
(B3VP13)		 
[query] 45 - 259 (324)
[subject] 1 - 216 (216)
 1e-38 164   42% Putative cyclase/dehydratase uncultured bacterium
92
 B3VNZ5_9BACT
(B3VNZ5)		 
[query] 45 - 259 (324)
[subject] 1 - 216 (216)
 2e-38 164   42% Putative cyclase/dehydratase uncultured bacterium
93
 B3VP12_9BACT
(B3VP12)		 
[query] 45 - 259 (324)
[subject] 1 - 216 (216)
 2e-38 164   42% Putative cyclase/dehydratase uncultured bacterium
94
 B3VNZ9_9BACT
(B3VNZ9)		 
[query] 45 - 259 (324)
[subject] 1 - 216 (216)
 2e-38 164   42% Putative cyclase/dehydratase uncultured bacterium
95
 B3VP04_9BACT
(B3VP04)		 
[query] 45 - 258 (324)
[subject] 1 - 215 (215)
 2e-38 164   43% Putative cyclase/dehydratase uncultured bacterium
96
 B3VP07_9BACT
(B3VP07)		 
[query] 45 - 259 (324)
[subject] 1 - 216 (216)
 3e-38 163   42% Putative cyclase/dehydratase uncultured bacterium
97
 B3VP02_9BACT
(B3VP02)		 
[query] 45 - 259 (324)
[subject] 1 - 216 (216)
 6e-38 162   42% Putative cyclase/dehydratase uncultured bacterium
98
 B3VNY8_9ACTO
(B3VNY8)		 
[query] 45 - 259 (324)
[subject] 1 - 214 (214)
 8e-38 162   43% Putative cyclase/dehydratase Micromonospora sp. 8g107
99
 B3VNZ0_9BACT
(B3VNZ0)		 
[query] 45 - 259 (324)
[subject] 1 - 216 (216)
 1e-37 161   42% Putative cyclase/dehydratase uncultured bacterium
100
 B3VNZ2_9BACT
(B3VNZ2)		 
[query] 45 - 259 (324)
[subject] 1 - 216 (216)
 1e-37 161   42% Putative cyclase/dehydratase uncultured bacterium
accessionDBalignmentEvalueScoreIdent.linkinformationpubmed
1
 CYPK_STRVN
(P16560)		 
[query] 1 - 324 (324)
[subject] 1 - 324 (324)
 0.0 645   100%
Product
Granaticin polyketide synthase bifunctional cyclase/dehydratase
Gene
gra-orf4
Organism
Streptomyces violaceoruber
1uniprot[Pubmed] 2583128 [Medline] 90060034
Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber Tu22.(EMBO J.) [1989]
2uniprot[Pubmed] 7476861 [Medline] 96027933
Identification of Streptomyces violaceoruber Tu22 genes involved in the biosynthesis of granaticin.(Mol. Gen. Genet.) [1995]
3uniprot[Pubmed] 9831526 [Medline] 99051446
The granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tu22: sequence analysis and expression in a heterologous host.(Chem. Biol.) [1998]
[pubmed all]
4
 Q9FCM5_STRAT
(Q9FCM5)		 
[query] 16 - 318 (324)
[subject] 6 - 307 (318)
 1e-105 385   63%
Product
Putative aromatase
Gene
 
Organism
Streptomyces antibioticus
1uniprot[Pubmed] 11700358 [Medline] 21557167
A polyketide biosynthetic gene cluster from Streptomyces antibioticus includes a LysR-type transcriptional regulator.(Microbiology) [2001]
5
 Q9X464_STRAE
(Q9X464)		 Jump to Naphcy_00040 
[query] 19 - 318 (324)
[subject] 10 - 308 (315)
 6e-94 348   61%
Product
Aromatase
Gene
ncnD
Organism
Streptomyces arenae
1uniprot[Pubmed] 10206788 [Medline] 99217421
Isolation and characterization of the naphthocyclinone gene cluster from Streptomyces arenae DSM 40737 and heterologous expression of the polyketide synthase genes.(Gene) [1999]
6
 Q2J5J6_FRASC
(Q2J5J6)		 
[query] 14 - 318 (324)
[subject] 2 - 307 (319)
 7e-80 301   51%
Product
Actinorhodin polyketide synthase bifunctional cyclase/dehydratase
Gene
Francci3_4098
Organism
Frankia sp. (strain CcI3)
1uniprot[Pubmed] 17151343
Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007]
10
 Q93LY0_9ACTO
(Q93LY0)		 
[query] 20 - 322 (324)
[subject] 10 - 311 (314)
 5e-72 276   46%
Product
Putative bifunctional aromatase PgaL
Gene
pgaL
Organism
Streptomyces sp. PGA64
1uniprot[Pubmed] 12654660 [Medline] 22540650
Engineering anthracycline biosynthesis toward angucyclines.(Antimicrob. Agents Chemother.) [2003]
2uniprot[Pubmed] 15515887
Partial activation of a silent angucycline-type gene cluster from a rubromycin beta producing Streptomyces sp. PGA64.(J. Antibiot.) [2004]
[pubmed all]
11
 CYPK_STRCO
(Q02055)		 Jump to Actino_00210 
[query] 11 - 316 (324)
[subject] 1 - 307 (316)
 6e-72 275   51%
Product
Actinorhodin polyketide synthase bifunctional cyclase/dehydratase
ACTVII
actI ORF4
Gene
SCO5090
SCBAC28G1.16
Organism
Streptomyces coelicolor
1uniprot[Pubmed] 1527048 [Medline] 92406871
Nucleotide sequence and deduced functions of a set of cotranscribed genes of Streptomyces coelicolor A3(2) including the polyketide synthase for the antibiotic actinorhodin.(J. Biol. Chem.) [1992]
2uniprot[Pubmed] 12000953 [Medline] 21996410
Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).(Nature) [2002]
[pubmed all]
12
 Q54221_STRGR
(Q54221)		 Jump to Griseu_00050 
[query] 11 - 322 (324)
[subject] 1 - 311 (319)
 2e-71 273   45%
Product
Putative cyclase/dehydrase
Gene
 
Organism
Streptomyces griseus
1uniprot[Pubmed] 8169211 [Medline] 94222841
Cloning, sequencing, and analysis of the griseusin polyketide synthase gene cluster from Streptomyces griseus.(J. Bacteriol.) [1994]
16
 C4NYK3_9ACTO
(C4NYK3)		 
[query] 20 - 323 (324)
[subject] 10 - 312 (314)
 3e-70 270   47%
Product
SaqL
Gene
saqL
Organism
Micromonospora sp. Tu 6368
1uniprot[Pubmed] 17497146
A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]
2uniprot[Pubmed] 19384899
Cloning and sequencing of the biosynthetic gene cluster for saquayamycin z and galtamycin B and the elucidation of the assembly of their saccharide chains.(Chembiochem) [2009]
[pubmed all]
18
 Q2HR24_9ACTO
(Q2HR24)		 Jump to Sch475_00340 
[query] 15 - 322 (324)
[subject] 2 - 309 (312)
 6e-70 269   45%
Product
Putative aromatase
Gene
schP4
Organism
Streptomyces sp. SCC 2136
1uniprot
Angucyclines Sch 47554 and Sch 47555 from Streptomyces sp. SCC-2136: Cloning, Sequencing, and Characterization.(Mol. Cells) [2006]
2uniprot
Molecular cloning and characterization of biosynthetic genes cluster of Sch 47554 from Streptomyces sp. SCC 2136. [2004]
20
 Q9RPB1_STRFR
(Q9RPB1)		 Jump to Urd_00160 
[query] 15 - 323 (324)
[subject] 2 - 309 (311)
 9e-70 268   45%
Product
Cyclase
Gene
urdL
Organism
Streptomyces fradiae
Streptomyces roseoflavus
1uniprot[Pubmed] 10658661 [Medline] 20121748
Two new tailoring enzymes, a glycosyltransferase and an oxygenase, involved in biosynthesis of the angucycline antibiotic urdamycin A in Streptomyces fradiae Tu2717.(Microbiology) [2000]
21
 Q47QK9_THEFY
(Q47QK9)		 
[query] 14 - 314 (324)
[subject] 3 - 303 (314)
 6e-69 265   45%
Product
Actinorhodin polyketide synthase bifunctional cyclase/dehydratase
Gene
Tfu_1222
Organism
Thermobifida fusca (strain YX)
1uniprot[Pubmed] 17209016
Genome sequence and analysis of the soil cellulolytic actinomycete Thermobifida fusca YX.(J. Bacteriol.) [2007]
22
 Q2J5F1_FRASC
(Q2J5F1)		 
[query] 20 - 324 (324)
[subject] 13 - 316 (318)
 6e-69 265   47%
Product
Actinorhodin polyketide synthase bifunctional cyclase/dehydratase
Gene
Francci3_4143
Organism
Frankia sp. (strain CcI3)
1uniprot[Pubmed] 17151343
Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007]
23
 D2XDY3_9PSEU
(D2XDY3)		 
[query] 11 - 323 (324)
[subject] 1 - 314 (316)
 2e-68 264   43%
Product
AzicE
Gene
azicE
Organism
Kibdelosporangium sp. MJ126-NF4
1uniprot[Pubmed] 19928906
Biosynthetic studies of aziridine formation in azicemicins.(J. Am. Chem. Soc.) [2009]
24
 D5MRI9_9ACTO
(D5MRI9)		 
[query] 15 - 322 (324)
[subject] 2 - 308 (311)
 2e-67 260   45%
Product
Putative aromatase
Gene
hrbP
Organism
Streptomyces sp. 2238-SVT4
1uniprot[Pubmed] 20453135
Cloning and characterization of a gene cluster for hatomarubigin biosynthesis in Streptomyces sp. strain 2238-SVT4.(Appl. Environ. Microbiol.) [2010]
25
 Q9AMI9_STRAT
(Q9AMI9)		 
[query] 20 - 323 (324)
[subject] 10 - 313 (315)
 2e-67 260   46%
Product
Putative cyclase/dehydrase SimA5
Sim6
Gene
simA5
sim6
Organism
Streptomyces antibioticus
1uniprot[Pubmed] 11959542 [Medline] 21955989
Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibiotic.(Antimicrob. Agents Chemother.) [2002]
2uniprot[Pubmed] 12115055 [Medline] 22109063
Cloning and analysis of the simocyclinone biosynthetic gene cluster of Streptomyces antibioticus Tu 6040.(Arch. Microbiol.) [2002]
[pubmed all]
26
 Q7WT27_9ACTO
(Q7WT27)		 Jump to Medem_00150 
[query] 11 - 321 (324)
[subject] 1 - 314 (318)
 5e-67 259   46%
Product
First ring aromatase (ARO)
Gene
med-ORF19
Organism
Streptomyces sp. AM-7161
1uniprot
Cloning, sequencing and heterologous expression of the medermycin biosynthetic gene cluster of Streptomyces sp. AM-7161: towards comparative analysis of the benzoisochromanequione gene clusters.(Microbiology (Mosc.)) [2003]
27
 D6MSV2_9ACTO
(D6MSV2)		 
[query] 19 - 317 (324)
[subject] 9 - 307 (314)
 6e-67 259   46%
Product
SsfY1
Gene
ssfY1
Organism
Streptomyces sp. SF2575
1uniprot[Pubmed] 19908837
Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.(J. Am. Chem. Soc.) [2009]
28
 F2RC19_STRVP
(F2RC19)		 
[query] 15 - 322 (324)
[subject] 2 - 308 (311)
 1e-66 258   45%
Product
Bifunctional cyclase or dehydrase
Gene
SVEN_5984
Organism
Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
1uniprot[Pubmed] 21463507
Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes.(BMC Genomics) [2011]
29
 Q93M00_STRAU
(Q93M00)		 
[query] 11 - 324 (324)
[subject] 1 - 314 (316)
 1e-66 258   43%
Product
Cyclase/dehydratase-like protein
Gene
aur2F
Organism
Streptomyces aureofaciens
1uniprot[Pubmed] 15497441
Cloning and characterization of a new polyketide synthase gene cluster in Streptomyces aureofaciens CCM 3239.(DNA Seq.) [2004]
30
 D9UBK6_STRPR
(D9UBK6)		 
[query] 16 - 324 (324)
[subject] 6 - 314 (318)
 1e-66 258   45%
Product
Putative cyclase
Gene
c104_07c
Organism
Streptomyces pristinaespiralis
1uniprot[Pubmed] 21342465
Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011]
32
 Q9ZGD3_STRCY
(Q9ZGD3)		 Jump to Lando_00070 
[query] 15 - 323 (324)
[subject] 2 - 316 (319)
 2e-66 257   44%
Product
Cyclase homolog
Gene
lanL
Organism
Streptomyces cyanogenus
1uniprot[Pubmed] 9933932 [Medline] 99132695
Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin biosynthesis.(FEMS Microbiol. Lett.) [1999]
33
 Q54490_STRNO
(Q54490)		 Jump to Nogl_00320 
[query] 15 - 322 (324)
[subject] 9 - 317 (323)
 4e-66 256   46%
Product
SnoaE
Gene
snoaE
Organism
Streptomyces nogalater
1uniprot[Pubmed] 8668120 [Medline] 96242142
A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.(Mol. Gen. Genet.) [1996]
2uniprot[Pubmed] 9349712 [Medline] 98007868
Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.(Mol. Gen. Genet.) [1997]
3uniprot[Pubmed] 8760909 [Medline] 96349102
Production of hybrid anthracycline antibiotics by heterologous expression of Streptomyces nogalater nogalamycin biosynthesis genes.(Microbiology) [1996]
[pubmed all]
36
 Q4R0M7_STRCX
(Q4R0M7)		 Jump to Chart_00050 
[query] 11 - 322 (324)
[subject] 1 - 310 (322)
 5e-66 256   45%
Product
ChaF protein
Gene
chaF
Organism
Streptomyces chartreusis
1uniprot[Pubmed] 15911378
Biosynthesis of the antitumor agent chartreusin involves the oxidative rearrangement of an anthracyclic polyketide.(Chem. Biol.) [2005]
39
 Q56H98_STRAU
(Q56H98)		 
[query] 11 - 322 (324)
[subject] 1 - 311 (320)
 3e-65 253   42%
Product
Aur1H
Gene
aur1H
Organism
Streptomyces aureofaciens
1uniprot[Pubmed] 12384301 [Medline] 22271582
Cloning and characterization of a polyketide synthase gene cluster involved in biosynthesis of a proposed angucycline-like polyketide auricin in Streptomyces aureofaciens CCM 3239.(Gene) [2002]
2uniprot[Pubmed] 16079347
Characterization of a regulatory gene essential for the production of the angucycline-like polyketide antibiotic auricin in Streptomyces aureofaciens CCM 3239.(Microbiology) [2005]
3uniprot[Pubmed] 20466770
The role of the TetR-family transcriptional regulator Aur1R in negative regulation of the auricin gene cluster in Streptomyces aureofaciens CCM 3239.(Microbiology) [2010]
[pubmed all]
42
 Q9L554_9ACTO
(Q9L554)		 Jump to Acla_00040 
[query] 16 - 323 (324)
[subject] 5 - 310 (450)
 3e-64 249   46%
Product
AknE1
Gene
aknE1
Organism
Streptomyces galilaeus
1uniprot[Pubmed] 12137949 [Medline] 22133312
Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster.(Gene) [2002]
44
 Q8VWB6_9ACTO
(Q8VWB6)		 
[query] 16 - 322 (324)
[subject] 5 - 309 (450)
 1e-63 248   46%
Product
AknE1
Gene
aknE1
Organism
Streptomyces galilaeus
1uniprot[Pubmed] 12399480 [Medline] 22286521
Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus.(J. Bacteriol.) [2002]
45
 Q6VMJ1_STRAM
(Q6VMJ1)		 
[query] 15 - 323 (324)
[subject] 2 - 311 (314)
 1e-63 248   43%
Product
Putative bifunctional cyclase/dehydrase
Putative cyclase/dehydratase
Gene
alpE
DSMT0181
Organism
Streptomyces ambofaciens
1uniprot[Pubmed] 14742212
Functional angucycline-like antibiotic gene cluster in the terminal inverted repeats of the Streptomyces ambofaciens linear chromosome.(Antimicrob. Agents Chemother.) [2004]
2uniprot[Pubmed] 16952952
Intraspecific variability of the terminal inverted repeats of the linear chromosome of Streptomyces ambofaciens.(J. Bacteriol.) [2006]
[pubmed all]
46
 Q1RQS4_STRAM
(Q1RQS4)		 
[query] 15 - 323 (324)
[subject] 2 - 311 (314)
 1e-63 248   43%
Product
Putative cyclase/dehydratase
Gene
alpE
SAMT0161
SAMT0162
Organism
Streptomyces ambofaciens ATCC 23877
1uniprot[Pubmed] 16952952
Intraspecific variability of the terminal inverted repeats of the linear chromosome of Streptomyces ambofaciens.(J. Bacteriol.) [2006]
2uniprot[Pubmed] 16956972
Evolution of the terminal regions of the Streptomyces linear chromosome.(Mol. Biol. Evol.) [2006]
3uniprot
Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877.(Microbiology (Mosc.)) [2006]
[pubmed all]
47
 Q56167_9ACTO
(Q56167)		 Jump to Jado_00120 
[query] 15 - 322 (324)
[subject] 2 - 307 (310)
 2e-63 247   44%
Product
Bifunctional cyclase/dehydrase
Gene
 
Organism
Streptomyces venezuelae
1uniprot[Pubmed] 7881555 [Medline] 95187308
Cloning and characterization of polyketide synthase genes for jadomycin B biosynthesis in Streptomyces venezuelae ISP5230.(Microbiology) [1994]
2uniprot
Functional characterization of the jadI gene as a cyclase forming angucyclinones.(J. Am. Chem. Soc.) [1999]
49
 C7QAF6_CATAD
(C7QAF6)		 
[query] 16 - 322 (324)
[subject] 6 - 312 (316)
 3e-63 246   42%
Product
Cyclase/dehydrase
Gene
Caci_3550
Organism
Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
1uniprot
Complete genome sequence of Catenulispora acidiphila type strain (ID 139908).(Stand. Genomic Sci.) [2009]
51
 D7BZR8_STRBB
(D7BZR8)		 
[query] 21 - 316 (324)
[subject] 11 - 312 (324)
 4e-62 243   43%
Product
Actinorhodin polyketide synthase bifunctional cyclase/dehydratase
Gene
SBI_06853
Organism
Streptomyces bingchenggensis (strain BCW-1)
1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]
53
 D7RFJ9_AMYOR
(D7RFJ9)		 
[query] 19 - 322 (324)
[subject] 4 - 306 (309)
 4e-61 239   44%
Product
Putative cyclase
Gene
bexL
Organism
Amycolatopsis orientalis subsp. vinearia
1uniprot[Pubmed] 20443562
A biosynthetic pathway for BE-7585A, a 2-thiosugar-containing angucycline-type natural product.(J. Am. Chem. Soc.) [2010]
54
 B6SEF5_9ACTO
(B6SEF5)		 Jump to Alnu_00100 
[query] 13 - 317 (324)
[subject] 12 - 321 (331)
 1e-58 231   45%
Product
AlnQ aromatase
Gene
alnQ
Organism
Streptomyces sp. CM020
1uniprot[Pubmed] 18940666
Characterization of the alnumycin gene cluster reveals unusual gene products for pyran ring formation and dioxan biosynthesis.(Chem. Biol.) [2008]
55
 Q9ZG83_STRRM
(Q9ZG83)		 
[query] 11 - 290 (324)
[subject] 1 - 280 (297)
 3e-56 223   43%
Product
Cyclase/aromatase
Gene
otcD1
Organism
Streptomyces rimosus
1uniprot[Pubmed] 10551844 [Medline] 20020252
Disruption of an aromatase/cyclase from the oxytetracycline gene cluster of Streptomyces rimosus results in production of novel polyketides with shorter chain lengths.(J. Biol. Chem.) [1999]
2uniprot
Characterisation of some genes involved in the early steps of the biosynthetic pathway for oxytetracycline in Streptomyces rimosus. [1994]
56
 Q54811_STRPE
(Q54811)		 Jump to Adria_00240 
[query] 16 - 322 (324)
[subject] 6 - 312 (315)
 5e-56 222   43%
Product
Daunorubicin-doxorubicin polyketide synthase
Gene
dpsF
Organism
Streptomyces peucetius
1uniprot[Pubmed] 7828855 [Medline] 95129838
Characterization of the Streptomyces peucetius ATCC 29050 genes encoding doxorubicin polyketide synthase.(Gene) [1994]
57
 Q3S8Q5_STRRM
(Q3S8Q5)		 Jump to Oxtet_00110 
[query] 11 - 322 (324)
[subject] 1 - 312 (317)
 6e-56 222   44%
Product
OxyK
Gene
oxyK
Organism
Streptomyces rimosus
1uniprot[Pubmed] 16597959
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.(Appl. Environ. Microbiol.) [2006]
58
 Q55220_STRSQ
(Q55220)		 Jump to Dauno_00130 
[query] 16 - 323 (324)
[subject] 6 - 309 (315)
 8e-56 222   43%
Product
Cyclase/dehydrase
Gene
dauA
Organism
Streptomyces sp
1uniprot[Pubmed] 7928998 [Medline] 95014072
Isolation and sequence analysis of polyketide synthase genes from the daunomycin-producing Streptomyces sp. strain C5.(J. Bacteriol.) [1994]
59
 D1A6S1_THECD
(D1A6S1)		 
[query] 21 - 319 (324)
[subject] 30 - 327 (340)
 9e-56 221   43%
Product
Cyclase/dehydrase
Gene
Tcur_2780
Organism
Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
1uniprot
Complete genome sequence of Thermomonospora curvata type strain (B9).(Stand. Genomic Sci.) [2011]
60
 Q83X42_STRRO
(Q83X42)		 
[query] 16 - 324 (324)
[subject] 9 - 317 (321)
 2e-55 220   43%
Product
Cyclase/aromatase
Gene
rocH
Organism
Streptomyces rochei
Streptomyces parvullus
1uniprot[Pubmed] 12791134 [Medline] 22676866
The large linear plasmid pSLA2-L of Streptomyces rochei has an unusually condensed gene organization for secondary metabolism.(Mol. Microbiol.) [2003]
2uniprot[Pubmed] 10954087 [Medline] 20408175
Cloning and analysis of the replication origin and the telomeres of the large linear plasmid pSLA2-L in Streptomyces rochei.(Mol. Gen. Genet.) [2000]
3uniprot[Pubmed] 10767533 [Medline] 20231737
Identification of two polyketide synthase gene clusters on the linear plasmid pSLA2-L in Streptomyces rochei.(Gene) [2000]
4uniprot[Pubmed] 9836424 [Medline] 99053144
Physical mapping of the linear plasmid pSLA2-L and localization of the eryAI and actI homologs.(Biosci. Biotechnol. Biochem.) [1998]
[pubmed all]
61
 C7PWQ8_CATAD
(C7PWQ8)		 
[query] 18 - 322 (324)
[subject] 17 - 330 (330)
 8e-52 208   43%
Product
Actinorhodin polyketide synthase bifunctional cyclase/dehydratase
Gene
Caci_6488
Organism
Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
1uniprot
Complete genome sequence of Catenulispora acidiphila type strain (ID 139908).(Stand. Genomic Sci.) [2009]
62
 B7TX46_9ACTO
(B7TX46)		 
[query] 45 - 259 (324)
[subject] 1 - 214 (214)
 2e-51 207   50%
Product
Putative cyclase/dehydratase
Gene
 
Organism
Streptomyces sp. 6G13
1uniprot[Pubmed] 21287404
A method to type the potential angucycline producers in actinomycetes isolated from marine sponges.(Antonie Van Leeuwenhoek) [2011]
64
 Q7X2H2_9ACTO
(Q7X2H2)		 Jump to Gilvo_00220 
[query] 21 - 317 (324)
[subject] 10 - 305 (316)
 1e-49 201   38%
Product
Putative cyclase/dehydratase
Gene
gilK
Organism
Streptomyces griseoflavus
1uniprot[Pubmed] 12822997 [Medline] 22708304
The complete gene cluster of the antitumor agent gilvocarcin V and its implication for the biosynthesis of the gilvocarcins.(J. Am. Chem. Soc.) [2003]
66
 Q54999_9ACTO
(Q54999)		 Jump to Fren_00170 
[query] 19 - 317 (324)
[subject] 14 - 321 (331)
 1e-47 194   41%
Product
Aromatase
Gene
frnQ
Organism
Streptomyces roseofulvus
1uniprot[Pubmed] 8181754 [Medline] 94237486
Cloning, sequencing and deduced functions of a cluster of Streptomyces genes probably encoding biosynthesis of the polyketide antibiotic frenolicin.(Gene) [1994]
68
 Q53669_STRAA
(Q53669)		 Jump to Mith_00120 
[query] 11 - 324 (324)
[subject] 1 - 313 (315)
 3e-45 186   36%
Product
Aromatase
Gene
mtmQ
Organism
Streptomyces argillaceus
1uniprot[Pubmed] 8654997 [Medline] 96257259
Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144
An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479
Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047
Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478
Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236
Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456
Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776
The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809
Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752
The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297
Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254
Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461
Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994
Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398
Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238
Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589
MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823
Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316
Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873
The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]
[pubmed all]
70
 CYPK_STRCM
(P41178)		 
[query] 15 - 312 (324)
[subject] 2 - 298 (304)
 2e-44 184   39%
Product
Granaticin polyketide synthase bifunctional cyclase/dehydratase
ORF4
Gene
 
Organism
Streptomyces cinnamonensis
1uniprot[Pubmed] 1508151 [Medline] 92374994
Characterisation of actI-homologous DNA encoding polyketide synthase genes from the monensin producer Streptomyces cinnamonensis.(Mol. Gen. Genet.) [1992]
72
 Q2PA00_9ACTO
(Q2PA00)		 Jump to Stref_00150 
[query] 11 - 322 (324)
[subject] 1 - 304 (309)
 2e-42 177   35%
Product
Aromatase
Gene
stfQ
Organism
Streptomyces steffisburgensis
1uniprot[Pubmed] 16751529
Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin.(Appl. Environ. Microbiol.) [2006]
73
 Q93HA9_STRAW
(Q93HA9)		 
[query] 13 - 324 (324)
[subject] 11 - 320 (322)
 3e-41 173   36%
Product
Aromatase
Putative aromatase
Gene
SAV2383
SAV_2383
Organism
Streptomyces avermitilis
1uniprot[Pubmed] 11572948 [Medline] 21477403
Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.(Proc. Natl. Acad. Sci. U.S.A.) [2001]
2uniprot[Pubmed] 12692562 [Medline] 22608306
Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis.(Nat. Biotechnol.) [2003]
[pubmed all]
75
 B7TX48_9ACTO
(B7TX48)		 
[query] 45 - 259 (324)
[subject] 1 - 216 (216)
 5e-40 169   43%
Product
Putative cyclase/dehydratase
Gene
 
Organism
Streptomyces sp. 6G17
1uniprot[Pubmed] 21287404
A method to type the potential angucycline producers in actinomycetes isolated from marine sponges.(Antonie Van Leeuwenhoek) [2011]
76
 B7TX47_9ACTO
(B7TX47)		 
[query] 45 - 259 (324)
[subject] 1 - 216 (216)
 5e-40 169   43%
Product
Putative cyclase/dehydratase
Gene
 
Organism
Streptomyces sp. 6G8
1uniprot[Pubmed] 21287404
A method to type the potential angucycline producers in actinomycetes isolated from marine sponges.(Antonie Van Leeuwenhoek) [2011]
79
 B7TX44_9ACTO
(B7TX44)		 
[query] 45 - 259 (324)
[subject] 1 - 216 (216)
 3e-39 167   42%
Product
Putative cyclase/dehydratase
Gene
 
Organism
Streptomyces sp. 6G6
1uniprot[Pubmed] 21287404
A method to type the potential angucycline producers in actinomycetes isolated from marine sponges.(Antonie Van Leeuwenhoek) [2011]
89
 B3VNY7_9ACTO
(B3VNY7)		 
[query] 45 - 259 (324)
[subject] 1 - 216 (216)
 9e-39 165   42%
Product
Putative cyclase/dehydratase
Gene
 
Organism
Streptomyces sp. 4MN1
1uniprot[Pubmed] 21287404
A method to type the potential angucycline producers in actinomycetes isolated from marine sponges.(Antonie Van Leeuwenhoek) [2011]
98
 B3VNY8_9ACTO
(B3VNY8)		 
[query] 45 - 259 (324)
[subject] 1 - 214 (214)
 8e-38 162   43%
Product
Putative cyclase/dehydratase
Gene
 
Organism
Micromonospora sp. 8g107
1uniprot[Pubmed] 21287404
A method to type the potential angucycline producers in actinomycetes isolated from marine sponges.(Antonie Van Leeuwenhoek) [2011]