BLAST table : Grana_00270

DBUniProtKB
accessionDBalignmentEvalueScoreIdent.linkproductgeneorganismec
1
 KAS2_STRVN
(P16541)		 
[query] 1 - 415 (415)
[subject] 1 - 415 (415)
 0.0 810   100% Granaticin polyketide putative beta-ketoacyl synthase 2
ORF2		 gra-orf2 Streptomyces violaceoruber 2.3.1.-
2
 E3T4B1_9ACTO
(E3T4B1)		 
[query] 1 - 405 (415)
[subject] 1 - 415 (419)
 1e-180 637   80% Polyketide synthase chain length factor gra-orf2 Streptomyces vietnamensis
3
 D3U1U8_9BACT
(D3U1U8)		 
[query] 8 - 405 (415)
[subject] 4 - 403 (407)
 1e-139 499   68% Keto-acyl synthase beta uncultured soil bacterium V167
4
 Q9X462_STRAE
(Q9X462)		 Jump to Naphcy_00020 
[query] 19 - 405 (415)
[subject] 37 - 425 (429)
 1e-137 493   70% Chain length factor ncnB Streptomyces arenae
5
 Q9FCM7_STRAT
(Q9FCM7)		 
[query] 10 - 411 (415)
[subject] 4 - 405 (405)
 1e-133 480   67% Putative chain length factor Streptomyces antibioticus
6
 D9W8F9_9ACTO
(D9W8F9)		 
[query] 10 - 404 (415)
[subject] 12 - 408 (413)
 1e-132 478   67% Granaticin polyketide putative beta-ketoacyl synthase 2 SSOG_02381 Streptomyces himastatinicus ATCC 53653
7
 Q7WT09_9ACTO
(Q7WT09)		 Jump to Medem_00330 
[query] 8 - 404 (415)
[subject] 4 - 402 (408)
 1e-128 462   63% Ketosynthase (KS) beta subunit med-ORF2 Streptomyces sp. AM-7161
8
 KASB_STRCO
(Q02062)		 Jump to Actino_00190 
[query] 10 - 404 (415)
[subject] 4 - 400 (407)
 1e-125 452   61% Actinorhodin polyketide putative beta-ketoacyl synthase 2
actI ORF2		 SCO5088
SCBAC28G1.14		 Streptomyces coelicolor 2.3.1.-
9
 D6EWA6_STRLI
(D6EWA6)		 
[query] 10 - 404 (415)
[subject] 4 - 400 (407)
 1e-124 450   59% Beta-ketoacyl synthase/acyl transferase SSPG_02601 Streptomyces lividans TK24
10
 E2D2I7_9BACT
(E2D2I7)		 
[query] 9 - 412 (415)
[subject] 2 - 404 (405)
 1e-121 440   60% Polyketide synthase uncultured soil bacterium
11
 D3CXU0_9ACTO
(D3CXU0)		 
[query] 10 - 404 (415)
[subject] 5 - 401 (412)
 1e-121 439   62% Beta-ketoacyl synthase FrEUN1fDRAFT_2360 Frankia sp. EUN1f
12
 D2XDY0_9PSEU
(D2XDY0)		 
[query] 10 - 404 (415)
[subject] 6 - 399 (403)
 1e-120 437   61% AzicB azicB Kibdelosporangium sp. MJ126-NF4
13
 Q6ZZW1_STRAT
(Q6ZZW1)		 Jump to Ovied_00120 
[query] 8 - 404 (415)
[subject] 7 - 403 (407)
 1e-118 431   58% Keto-acyl synthase beta ovmK Streptomyces antibioticus
14
 Q9F6E1_9ACTO
(Q9F6E1)		 Jump to R1128_00010 
[query] 1 - 404 (415)
[subject] 3 - 408 (415)
 1e-117 428   59% Chain length factor zhuA Streptomyces sp. R1128
15
 D9UBR9_STRPR
(D9UBR9)		 
[query] 10 - 404 (415)
[subject] 4 - 400 (402)
 1e-117 426   58% Putative ketoacylsynthase, chain length factor beta-subunit cpp15 Streptomyces pristinaespiralis 2.3.1.179
16
 B5HIV1_STRPR
(B5HIV1)		 
[query] 10 - 404 (415)
[subject] 4 - 400 (402)
 1e-117 426   58% Actinorhodin polyketide beta-ketoacyl synthase beta subunit SSDG_05088 Streptomyces pristinaespiralis ATCC 25486
17
 Q84CI1_9ACTO
(Q84CI1)		 
[query] 8 - 405 (415)
[subject] 7 - 404 (406)
 1e-116 423   57% Putative chain length determinant pd2B Streptomyces sp. WP 4669
18
 Q2J5J4_FRASC
(Q2J5J4)		 
[query] 7 - 404 (415)
[subject] 3 - 398 (400)
 1e-115 421   59% Beta-ketoacyl synthase Francci3_4100 Frankia sp. (strain CcI3)
19
 D1XRF0_9ACTO
(D1XRF0)		 
[query] 11 - 408 (415)
[subject] 6 - 403 (404)
 1e-115 420   56% Beta-ketoacyl synthase SACTEDRAFT_5260 Streptomyces sp. SA3_actE
20
 C4NYK0_9ACTO
(C4NYK0)		 
[query] 8 - 404 (415)
[subject] 4 - 401 (407)
 1e-115 419   59% SaqB saqB Micromonospora sp. Tu 6368
21
 Q48376_KIBAR
(Q48376)		 
[query] 8 - 404 (415)
[subject] 4 - 404 (410)
 1e-115 419   57% ArdIorf2 ardIorf2 Kibdelosporangium aridum
22
 B5HT07_9ACTO
(B5HT07)		 
[query] 10 - 404 (415)
[subject] 5 - 399 (403)
 1e-115 418   58% 3-oxoacyl-[acyl-carrier-protein] synthase 2 SSEG_09023 Streptomyces sviceus ATCC 29083
23
 Q84CJ6_9ACTO
(Q84CJ6)		 
[query] 10 - 404 (415)
[subject] 6 - 400 (403)
 1e-114 417   57% Putative chain length determinant kinB Streptomyces murayamaensis
24
 Q54282_SACHI
(Q54282)		 
[query] 11 - 404 (415)
[subject] 5 - 398 (403)
 1e-114 417   62% Polyketide synthase Saccharopolyspora hirsuta
25
 Q2HR21_9ACTO
(Q2HR21)		 Jump to Sch475_00370 
[query] 8 - 404 (415)
[subject] 6 - 403 (408)
 1e-113 412   58% Putative chain length factor schP7 Streptomyces sp. SCC 2136
26
 Q56HA1_STRAU
(Q56HA1)		 
[query] 8 - 404 (415)
[subject] 4 - 400 (404)
 1e-112 409   55% Aur1E aur1E Streptomyces aureofaciens
27
 Q9KHK5_9ACTO
(Q9KHK5)		 Jump to Enter_00100 
[query] 10 - 404 (415)
[subject] 6 - 403 (407)
 1e-112 409   58% Putative keto synthase beta EncB encB Streptomyces maritimus
28
 Q9ZGD6_STRCY
(Q9ZGD6)		 Jump to Lando_00040 
[query] 8 - 411 (415)
[subject] 4 - 406 (406)
 1e-112 409   54% Chain length factor homolog lanB Streptomyces cyanogenus
29
 B6SEF2_9ACTO
(B6SEF2)		 Jump to Alnu_00070 
[query] 1 - 404 (415)
[subject] 9 - 422 (428)
 1e-111 407   58% AlnM ketoacyl synthase beta alnM Streptomyces sp. CM020
30
 Q54174_STRFR
(Q54174)		 Jump to Urd_00130 
[query] 11 - 404 (415)
[subject] 10 - 404 (408)
 1e-111 407   56% Putative chain length determinant UrdB Streptomyces fradiae
Streptomyces roseoflavus
31
 F2RC16_STRVP
(F2RC16)		 
[query] 10 - 404 (415)
[subject] 6 - 400 (404)
 1e-110 404   58% Polyketide chain length factor SVEN_5981 Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
32
 Q54496_STRNO
(Q54496)		 Jump to Nogl_00380 
[query] 10 - 404 (415)
[subject] 6 - 401 (409)
 1e-110 404   57% Snoa2 snoa2 Streptomyces nogalater
33
 B0LJ49_9ACTO
(B0LJ49)		 
[query] 8 - 404 (415)
[subject] 4 - 403 (406)
 1e-110 404   54% Lcz32 lcz32 Streptomyces sanglieri
34
 D1H0J9_9ACTO
(D1H0J9)		 
[query] 11 - 404 (415)
[subject] 6 - 398 (401)
 1e-110 402   56% Putative chain length factor ravB Streptomyces sp. C23201NS3
35
 Q56164_9ACTO
(Q56164)		 Jump to Jado_00090 
[query] 10 - 404 (415)
[subject] 6 - 400 (404)
 1e-110 402   57% Chain length determinant Streptomyces venezuelae
36
 B0LJ15_9ACTO
(B0LJ15)		 
[query] 8 - 404 (415)
[subject] 4 - 403 (406)
 1e-109 400   56% Lct32 lct32 Streptomyces rishiriensis
37
 Q93LY3_9ACTO
(Q93LY3)		 
[query] 8 - 404 (415)
[subject] 4 - 401 (405)
 1e-108 398   56% Chain length determinant PgaB pgaB Streptomyces sp. PGA64
38
 Q4U0Y7_9ACTO
(Q4U0Y7)		 
[query] 8 - 404 (415)
[subject] 7 - 404 (408)
 1e-108 397   53% Type II PKS CLF domain Streptomyces nodosus
39
 Q9AMJ2_STRAT
(Q9AMJ2)		 
[query] 10 - 404 (415)
[subject] 6 - 400 (404)
 1e-107 395   57% Putative ketosynthase SimA2
Sim3		 simA2
sim3		 Streptomyces antibioticus
40
 F6K0W4_9BACT
(F6K0W4)		 
[query] 10 - 404 (415)
[subject] 11 - 405 (420)
 1e-107 392   57% Chain length determinant uncultured bacterium BAC AB649/1850
41
 D9W583_9ACTO
(D9W583)		 
[query] 8 - 404 (415)
[subject] 4 - 401 (405)
 1e-106 390   52% 3-oxoacyl-[acyl-carrier-protein] synthase 2 SSNG_07313 Streptomyces sp. C
42
 D6MSY2_9ACTO
(D6MSY2)		 
[query] 8 - 404 (415)
[subject] 10 - 408 (412)
 1e-105 386   53% SsfB ssfB Streptomyces sp. SF2575
43
 Q4R0M1_STRCX
(Q4R0M1)		 Jump to Chart_00110 
[query] 8 - 404 (415)
[subject] 4 - 401 (408)
 1e-105 385   57% ChaB protein chaB Streptomyces chartreusis
44
 E3J3P8_FRASU
(E3J3P8)		 
[query] 9 - 404 (415)
[subject] 5 - 401 (412)
 1e-104 385   60% Beta-ketoacyl synthase FraEuI1c_1318 Frankia sp. (strain EuI1c)
45
 Q8VWB2_9ACTO
(Q8VWB2)		 
[query] 10 - 404 (415)
[subject] 6 - 401 (407)
 1e-104 384   55% AknC aknC Streptomyces galilaeus
46
 Q2MGD0_STRGR
(Q2MGD0)		 Jump to Fred_00090 
[query] 10 - 404 (415)
[subject] 5 - 400 (403)
 1e-104 383   54% Chain length factor Streptomyces griseus
47
 Q3S8R3_STRRM
(Q3S8R3)		 Jump to Oxtet_00030 
[query] 8 - 407 (415)
[subject] 21 - 421 (422)
 1e-104 383   58% OxyB oxyB Streptomyces rimosus
48
 E2EKK0_9ACTO
(E2EKK0)		 
[query] 7 - 404 (415)
[subject] 23 - 420 (423)
 1e-104 383   53% Chain length factor sanG Streptomyces sp. SANK 61196
49
 Q9FAR4_STRAU
(Q9FAR4)		 
[query] 10 - 405 (415)
[subject] 5 - 400 (401)
 1e-104 383   56% Beta-ketoacyl synthase2 tcsE Streptomyces aureofaciens
50
 Q9L550_9ACTO
(Q9L550)		 Jump to Acla_00080 
[query] 10 - 415 (415)
[subject] 6 - 405 (407)
 1e-104 382   54% AknC aknC Streptomyces galilaeus
51
 Q6VMI8_STRAM
(Q6VMI8)		 
[query] 10 - 404 (415)
[subject] 6 - 400 (403)
 1e-103 381   58% Putative chain length determinant alpB
DSMT0184		 Streptomyces ambofaciens
52
 Q1RQS1_STRAM
(Q1RQS1)		 
[query] 10 - 404 (415)
[subject] 6 - 400 (403)
 1e-103 381   58% Putative chain length determinant alpB
SAMT0164
SAMT0165		 Streptomyces ambofaciens ATCC 23877
53
 KAS2_STRGA
(P16539)		 
[query] 10 - 408 (415)
[subject] 8 - 409 (409)
 1e-103 380   53% Tetracenomycin C polyketide putative beta-ketoacyl synthase 2 tcmL Streptomyces glaucescens 2.3.1.-
54
 Q54218_STRGR
(Q54218)		 Jump to Griseu_00020 
[query] 1 - 404 (415)
[subject] 1 - 408 (412)
 1e-103 378   53% Putative chain length determination factor Streptomyces griseus
55
 Q54815_STRPE
(Q54815)		 Jump to Adria_00280 
[query] 6 - 404 (415)
[subject] 24 - 421 (425)
 1e-102 378   56% Daunorubicin-doxorubicin polyketide synthase dpsB Streptomyces peucetius
56
 D2SZ00_MICEC
(D2SZ00)		 
[query] 7 - 404 (415)
[subject] 2 - 401 (405)
 1e-102 378   51% Ketosynthase Micromonospora echinospora subsp. challisensis
57
 C0JWB5_9ACTO
(C0JWB5)		 Jump to Polk_00200 
[query] 10 - 404 (415)
[subject] 5 - 403 (407)
 1e-102 376   54% PokP2 pokP2 Streptomyces diastatochromogenes
58
 B5G885_9ACTO
(B5G885)		 
[query] 12 - 404 (415)
[subject] 13 - 406 (412)
 1e-102 375   54% Tetracenomycin C polyketide beta-ketoacyl synthase 2 SSBG_00493 Streptomyces sp. SPB74
59
 Q55224_STRSQ
(Q55224)		 Jump to Dauno_00170 
[query] 10 - 404 (415)
[subject] 1 - 394 (398)
 1e-101 374   55% Polyketide synthase dauA Streptomyces sp
60
 D1A6R4_THECD
(D1A6R4)		 
[query] 7 - 404 (415)
[subject] 3 - 401 (405)
 1e-101 373   54% Beta-ketoacyl synthase Tcur_2772 Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
61
 A8KQX7_9ACTO
(A8KQX7)		 Jump to Ello_00120 
[query] 3 - 404 (415)
[subject] 6 - 408 (411)
 1e-101 373   55% Ketoacyl synthase beta elmL Streptomyces olivaceus
62
 C7PWQ6_CATAD
(C7PWQ6)		 
[query] 4 - 405 (415)
[subject] 26 - 428 (437)
 1e-101 372   55% Beta-ketoacyl synthase Caci_6486 Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
63
 D5MRH8_9ACTO
(D5MRH8)		 
[query] 9 - 404 (415)
[subject] 5 - 400 (404)
 1e-100 371   56% Putative chain length determinant factor hrbE Streptomyces sp. 2238-SVT4
64
 Q93LZ7_STRAU
(Q93LZ7)		 
[query] 10 - 404 (415)
[subject] 21 - 416 (420)
 1e-100 370   56% Chain length factor-like protein aur2B Streptomyces aureofaciens
65
 C7QAF3_CATAD
(C7QAF3)		 
[query] 9 - 410 (415)
[subject] 3 - 403 (403)
 1e-100 369   58% Beta-ketoacyl synthase Caci_3547 Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
66
 D1H0A2_9ACTO
(D1H0A2)		 
[query] 11 - 404 (415)
[subject] 6 - 398 (402)
 1e-99 368   56% Putative chain length factor (KSa) chryB Streptomyces albaduncus
67
 Q2PA08_9ACTO
(Q2PA08)		 Jump to Stref_00070 
[query] 10 - 407 (415)
[subject] 1 - 399 (406)
 7e-99 365   55% Chain length factor stfK Streptomyces steffisburgensis
68
 C7N0D2_SACVD
(C7N0D2)		 
[query] 2 - 404 (415)
[subject] 5 - 408 (411)
 7e-99 365   51% 3-oxoacyl-(Acyl-carrier-protein) synthase Svir_33700 Saccharomonospora viridis (strain ATCC 15386 / DSM 43017 / JCM 3036 / NBRC 12207 / P101)
69
 Q53672_STRAA
(Q53672)		 Jump to Mith_00150 
[query] 5 - 404 (415)
[subject] 4 - 404 (408)
 7e-98 362   56% MtmK protein mtmK Streptomyces argillaceus
70
 A1C178_9ACTO
(A1C178)		 Jump to Aran_00100 
[query] 10 - 405 (415)
[subject] 8 - 403 (408)
 7e-98 362   56% Chain length factor Streptomyces echinatus
71
 Q70J89_STRGR
(Q70J89)		 Jump to Chro_00090 
[query] 7 - 405 (415)
[subject] 2 - 400 (422)
 7e-98 362   52% Ketosynthase cmmK Streptomyces griseus subsp. griseus
72
 Q47QL2_THEFY
(Q47QL2)		 
[query] 10 - 404 (415)
[subject] 5 - 399 (402)
 9e-98 362   55% Actinorhodin polyketide beta-ketoacyl synthase beta subunit / 3-oxoacyl-ACP synthase II Tfu_1219 Thermobifida fusca (strain YX)
73
 E8SDG5_MICSL
(E8SDG5)		 
[query] 9 - 404 (415)
[subject] 4 - 396 (399)
 2e-97 360   58% Beta-ketoacyl synthase ML5_4403 Micromonospora sp. (strain L5)
74
 A4X725_SALTO
(A4X725)		 
[query] 9 - 404 (415)
[subject] 4 - 400 (428)
 1e-96 358   55% Beta-ketoacyl synthase Strop_2224 Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
75
 B1GSN2_9ACTO
(B1GSN2)		 Jump to Bena_00100 
[query] 10 - 404 (415)
[subject] 3 - 399 (409)
 2e-96 357   51% BenB protein benB Streptomyces sp. A2991200
76
 Q2PZR8_9ACTO
(Q2PZR8)		 Jump to Cosmo_00080 
[query] 10 - 404 (415)
[subject] 5 - 395 (414)
 4e-96 356   56% CosC cosC Streptomyces olindensis
77
 D7RFJ6_AMYOR
(D7RFJ6)		 
[query] 10 - 404 (415)
[subject] 22 - 414 (423)
 6e-96 355   56% Putative ketosynthase beta subunit bexB Amycolatopsis orientalis subsp. vinearia
78
 D9T2B5_MICAI
(D9T2B5)		 
[query] 9 - 404 (415)
[subject] 4 - 396 (399)
 9e-96 355   57% Beta-ketoacyl synthase Micau_4018 Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
79
 Q93HA1_STRAW
(Q93HA1)		 
[query] 2 - 405 (415)
[subject] 12 - 414 (416)
 4e-95 353   51% 3-oxoacyl-(Acyl carrier protein) synthase II
Putative 3-oxoacyl-ACP synthase II		 pks9-3
SAV2375
SAV_2375		 Streptomyces avermitilis
80
 O32452_9ACTO
(O32452)		 
[query] 11 - 410 (415)
[subject] 11 - 406 (407)
 6e-94 349   54% ORF 2 Actinomadura hibisca
81
 D8I4M0_AMYMU
(D8I4M0)		 
[query] 10 - 405 (415)
[subject] 15 - 405 (406)
 6e-94 349   51% 3-oxoacyl-[acyl-carrier-protein] synthase II fabF
AMED_5434		 Amycolatopsis mediterranei (strain U-32)
82
 D9UBT0_STRPR
(D9UBT0)		 
[query] 2 - 405 (415)
[subject] 21 - 421 (427)
 1e-93 348   55% Putative ketoacylsynthase, chain length factor beta-subunit cpp4 Streptomyces pristinaespiralis 2.3.1.179
83
 D7BZR0_STRBB
(D7BZR0)		 
[query] 9 - 405 (415)
[subject] 6 - 407 (412)
 3e-92 343   56% Beta-ketoacyl synthase SBI_06845 Streptomyces bingchenggensis (strain BCW-1)
84
 D1XH99_9ACTO
(D1XH99)		 
[query] 2 - 404 (415)
[subject] 12 - 413 (416)
 3e-92 343   49% Beta-ketoacyl synthase SACTEDRAFT_2150 Streptomyces sp. SA3_actE
85
 F4FBT6_VERMA
(F4FBT6)		 
[query] 9 - 405 (415)
[subject] 4 - 401 (402)
 1e-91 341   54% 3-oxoacyl-(Acyl-carrier-protein) synthase VAB18032_18170 Verrucosispora maris (strain AB-18-032)
86
 A1YZ63_9ACTO
(A1YZ63)		 
[query] 16 - 410 (415)
[subject] 1 - 391 (392)
 1e-91 341   53% PdmB pdmB Actinomadura hibisca
87
 Q6S9W5_9ACTO
(Q6S9W5)		 
[query] 11 - 405 (415)
[subject] 6 - 400 (433)
 8e-91 338   55% Chain length factor clf Streptomyces sp. 275
88
 E8W951_STRFA
(E8W951)		 
[query] 2 - 412 (415)
[subject] 9 - 422 (422)
 1e-90 338   54% Beta-ketoacyl synthase Sfla_5317 Streptomyces flavogriseus (strain ATCC 33331 / DSM 40990 / IAF-45CD)
89
 Q9XDZ9_9ACTO
(Q9XDZ9)		 
[query] 10 - 410 (415)
[subject] 27 - 427 (460)
 1e-90 338   55% Polyketide synthase Actinomadura verrucosospora
90
 D9W5B1_9ACTO
(D9W5B1)		 
[query] 10 - 408 (415)
[subject] 23 - 420 (421)
 2e-89 334   56% 3-oxoacyl-[acyl-carrier-protein] synthase 2 SSNG_07341 Streptomyces sp. C
91
 A7DWI8_STRTE
(A7DWI8)		 
[query] 1 - 409 (415)
[subject] 1 - 406 (414)
 2e-89 333   51% Putative beta-ketoacyl synthase beta (CLF) llpE Streptomyces tendae 2.3.1.-
92
 D2AY45_STRRD
(D2AY45)		 
[query] 7 - 405 (415)
[subject] 3 - 403 (406)
 1e-88 332   53% 3-oxoacyl-(Acyl-carrier-protein) synthase II Sros_4151 Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
93
 Q0RHJ8_FRAAA
(Q0RHJ8)		 
[query] 8 - 404 (415)
[subject] 26 - 426 (432)
 2e-86 324   49% Putative polyketide beta-ketoacyl synthase 2 (Pks family) FRAAL4386 Frankia alni (strain ACN14a) 2.3.-.-
94
 E5RLL8_9ACTO
(E5RLL8)		 
[query] 9 - 404 (415)
[subject] 16 - 413 (417)
 2e-86 324   51% Putative ketoacyl synthase pnxB Streptomyces sp. TA-0256
95
 Q83X36_STRRO
(Q83X36)		 
[query] 6 - 404 (415)
[subject] 14 - 412 (416)
 2e-84 318   55% Beta-ketoacyl synthase beta-subunit (Chain length factor) rocB Streptomyces rochei
Streptomyces parvullus
96
 KAS2_STRCM
(P41176)		 
[query] 11 - 404 (415)
[subject] 6 - 398 (402)
 7e-83 312   52% Putative polyketide beta-ketoacyl synthase 2
ORF 2		 Streptomyces cinnamonensis 2.3.1.-
97
 Q9FD18_STRCU
(Q9FD18)		 
[query] 3 - 404 (415)
[subject] 7 - 412 (422)
 1e-82 311   48% Ketosynthase beta subunit rubB Streptomyces collinus
98
 Q54995_9ACTO
(Q54995)		 Jump to Fren_00130 
[query] 10 - 401 (415)
[subject] 21 - 414 (426)
 5e-82 309   55% Chain length factor frnM Streptomyces roseofulvus
99
 Q8KSW3_9ACTO
(Q8KSW3)		 Jump to Griseo_00290 
[query] 6 - 404 (415)
[subject] 11 - 410 (420)
 1e-81 308   49% Putative ketosynthase beta GrhB grhB Streptomyces sp. JP95
100
 Q9RHT7_STRRO
(Q9RHT7)		 
[query] 6 - 404 (415)
[subject] 14 - 411 (415)
 4e-81 306   52% Chain length factor orf2 Streptomyces rochei
Streptomyces parvullus
accessionDBalignmentEvalueScoreIdent.linkinformationpubmed
1
 KAS2_STRVN
(P16541)		 
[query] 1 - 415 (415)
[subject] 1 - 415 (415)
 0.0 810   100%
Product
Granaticin polyketide putative beta-ketoacyl synthase 2
ORF2
Gene
gra-orf2
Organism
Streptomyces violaceoruber
1uniprot[Pubmed] 2583128 [Medline] 90060034
Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber Tu22.(EMBO J.) [1989]
2uniprot[Pubmed] 7476861 [Medline] 96027933
Identification of Streptomyces violaceoruber Tu22 genes involved in the biosynthesis of granaticin.(Mol. Gen. Genet.) [1995]
3uniprot[Pubmed] 9831526 [Medline] 99051446
The granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tu22: sequence analysis and expression in a heterologous host.(Chem. Biol.) [1998]
[pubmed all]
4
 Q9X462_STRAE
(Q9X462)		 Jump to Naphcy_00020 
[query] 19 - 405 (415)
[subject] 37 - 425 (429)
 1e-137 493   70%
Product
Chain length factor
Gene
ncnB
Organism
Streptomyces arenae
1uniprot[Pubmed] 10206788 [Medline] 99217421
Isolation and characterization of the naphthocyclinone gene cluster from Streptomyces arenae DSM 40737 and heterologous expression of the polyketide synthase genes.(Gene) [1999]
5
 Q9FCM7_STRAT
(Q9FCM7)		 
[query] 10 - 411 (415)
[subject] 4 - 405 (405)
 1e-133 480   67%
Product
Putative chain length factor
Gene
 
Organism
Streptomyces antibioticus
1uniprot[Pubmed] 11700358 [Medline] 21557167
A polyketide biosynthetic gene cluster from Streptomyces antibioticus includes a LysR-type transcriptional regulator.(Microbiology) [2001]
7
 Q7WT09_9ACTO
(Q7WT09)		 Jump to Medem_00330 
[query] 8 - 404 (415)
[subject] 4 - 402 (408)
 1e-128 462   63%
Product
Ketosynthase (KS) beta subunit
Gene
med-ORF2
Organism
Streptomyces sp. AM-7161
1uniprot
Cloning, sequencing and heterologous expression of the medermycin biosynthetic gene cluster of Streptomyces sp. AM-7161: towards comparative analysis of the benzoisochromanequione gene clusters.(Microbiology (Mosc.)) [2003]
8
 KASB_STRCO
(Q02062)		 Jump to Actino_00190 
[query] 10 - 404 (415)
[subject] 4 - 400 (407)
 1e-125 452   61%
Product
Actinorhodin polyketide putative beta-ketoacyl synthase 2
actI ORF2
Gene
SCO5088
SCBAC28G1.14
Organism
Streptomyces coelicolor
1uniprot[Pubmed] 1527048 [Medline] 92406871
Nucleotide sequence and deduced functions of a set of cotranscribed genes of Streptomyces coelicolor A3(2) including the polyketide synthase for the antibiotic actinorhodin.(J. Biol. Chem.) [1992]
2uniprot[Pubmed] 12000953 [Medline] 21996410
Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).(Nature) [2002]
[pubmed all]
10
 E2D2I7_9BACT
(E2D2I7)		 
[query] 9 - 412 (415)
[subject] 2 - 404 (405)
 1e-121 440   60%
Product
Polyketide synthase
Gene
 
Organism
uncultured soil bacterium
1uniprot[Pubmed] 20577994
Cloning large natural product gene clusters from the environment: piecing environmental DNA gene clusters back together with TAR.(Biopolymers) [2010]
12
 D2XDY0_9PSEU
(D2XDY0)		 
[query] 10 - 404 (415)
[subject] 6 - 399 (403)
 1e-120 437   61%
Product
AzicB
Gene
azicB
Organism
Kibdelosporangium sp. MJ126-NF4
1uniprot[Pubmed] 19928906
Biosynthetic studies of aziridine formation in azicemicins.(J. Am. Chem. Soc.) [2009]
14
 Q9F6E1_9ACTO
(Q9F6E1)		 Jump to R1128_00010 
[query] 1 - 404 (415)
[subject] 3 - 408 (415)
 1e-117 428   59%
Product
Chain length factor
Gene
zhuA
Organism
Streptomyces sp. R1128
1uniprot[Pubmed] 10931852 [Medline] 20517899
Cloning, nucleotide sequence, and heterologous expression of the biosynthetic gene cluster for R1128, a non-steroidal estrogen receptor antagonist. Insights into an unusual priming mechanism.(J. Biol. Chem.) [2000]
15
 D9UBR9_STRPR
(D9UBR9)		 
[query] 10 - 404 (415)
[subject] 4 - 400 (402)
 1e-117 426   58%
Product
Putative ketoacylsynthase, chain length factor beta-subunit
Gene
cpp15
Organism
Streptomyces pristinaespiralis
1uniprot[Pubmed] 21342465
Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011]
18
 Q2J5J4_FRASC
(Q2J5J4)		 
[query] 7 - 404 (415)
[subject] 3 - 398 (400)
 1e-115 421   59%
Product
Beta-ketoacyl synthase
Gene
Francci3_4100
Organism
Frankia sp. (strain CcI3)
1uniprot[Pubmed] 17151343
Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007]
20
 C4NYK0_9ACTO
(C4NYK0)		 
[query] 8 - 404 (415)
[subject] 4 - 401 (407)
 1e-115 419   59%
Product
SaqB
Gene
saqB
Organism
Micromonospora sp. Tu 6368
1uniprot[Pubmed] 17497146
A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]
2uniprot[Pubmed] 19384899
Cloning and sequencing of the biosynthetic gene cluster for saquayamycin z and galtamycin B and the elucidation of the assembly of their saccharide chains.(Chembiochem) [2009]
[pubmed all]
21
 Q48376_KIBAR
(Q48376)		 
[query] 8 - 404 (415)
[subject] 4 - 404 (410)
 1e-115 419   57%
Product
ArdIorf2
Gene
ardIorf2
Organism
Kibdelosporangium aridum
1uniprot[Pubmed] 7987007 [Medline] 95078455
Cloning and nucleotide sequence of a region of the Kibdelosporangium aridum genome homologous to polyketide biosynthetic genes.(DNA Seq.) [1994]
24
 Q54282_SACHI
(Q54282)		 
[query] 11 - 404 (415)
[subject] 5 - 398 (403)
 1e-114 417   62%
Product
Polyketide synthase
Gene
 
Organism
Saccharopolyspora hirsuta
1uniprot[Pubmed] 8341260 [Medline] 93341453
Saccharopolyspora hirsuta 367 encodes clustered genes similar to ketoacyl synthase, ketoacyl reductase, acyl carrier protein, and biotin carboxyl carrier protein.(Mol. Gen. Genet.) [1993]
25
 Q2HR21_9ACTO
(Q2HR21)		 Jump to Sch475_00370 
[query] 8 - 404 (415)
[subject] 6 - 403 (408)
 1e-113 412   58%
Product
Putative chain length factor
Gene
schP7
Organism
Streptomyces sp. SCC 2136
1uniprot
Angucyclines Sch 47554 and Sch 47555 from Streptomyces sp. SCC-2136: Cloning, Sequencing, and Characterization.(Mol. Cells) [2006]
2uniprot
Molecular cloning and characterization of biosynthetic genes cluster of Sch 47554 from Streptomyces sp. SCC 2136. [2004]
26
 Q56HA1_STRAU
(Q56HA1)		 
[query] 8 - 404 (415)
[subject] 4 - 400 (404)
 1e-112 409   55%
Product
Aur1E
Gene
aur1E
Organism
Streptomyces aureofaciens
1uniprot[Pubmed] 12384301 [Medline] 22271582
Cloning and characterization of a polyketide synthase gene cluster involved in biosynthesis of a proposed angucycline-like polyketide auricin in Streptomyces aureofaciens CCM 3239.(Gene) [2002]
2uniprot[Pubmed] 16079347
Characterization of a regulatory gene essential for the production of the angucycline-like polyketide antibiotic auricin in Streptomyces aureofaciens CCM 3239.(Microbiology) [2005]
3uniprot[Pubmed] 20466770
The role of the TetR-family transcriptional regulator Aur1R in negative regulation of the auricin gene cluster in Streptomyces aureofaciens CCM 3239.(Microbiology) [2010]
[pubmed all]
27
 Q9KHK5_9ACTO
(Q9KHK5)		 Jump to Enter_00100 
[query] 10 - 404 (415)
[subject] 6 - 403 (407)
 1e-112 409   58%
Product
Putative keto synthase beta EncB
Gene
encB
Organism
Streptomyces maritimus
1uniprot
Natural Metabolic Diversity Encoded by the Enterocin Biosynthesis Gene Cluster.(J. Am. Chem. Soc.) [2000]
2uniprot[Pubmed] 11137817 [Medline] 20579517
Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate 'Streptomyces maritimus': evidence for the derailment of an aromatic polyketide synthase.(Chem. Biol.) [2000]
3uniprot[Pubmed] 11948863 [Medline] 21942282
A mechanism of benzoic acid biosynthesis in plants and bacteria that mirrors fatty acid beta-oxidation.(Chembiochem) [2001]
[pubmed all]
28
 Q9ZGD6_STRCY
(Q9ZGD6)		 Jump to Lando_00040 
[query] 8 - 411 (415)
[subject] 4 - 406 (406)
 1e-112 409   54%
Product
Chain length factor homolog
Gene
lanB
Organism
Streptomyces cyanogenus
1uniprot[Pubmed] 9933932 [Medline] 99132695
Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin biosynthesis.(FEMS Microbiol. Lett.) [1999]
29
 B6SEF2_9ACTO
(B6SEF2)		 Jump to Alnu_00070 
[query] 1 - 404 (415)
[subject] 9 - 422 (428)
 1e-111 407   58%
Product
AlnM ketoacyl synthase beta
Gene
alnM
Organism
Streptomyces sp. CM020
1uniprot[Pubmed] 18940666
Characterization of the alnumycin gene cluster reveals unusual gene products for pyran ring formation and dioxan biosynthesis.(Chem. Biol.) [2008]
30
 Q54174_STRFR
(Q54174)		 Jump to Urd_00130 
[query] 11 - 404 (415)
[subject] 10 - 404 (408)
 1e-111 407   56%
Product
Putative chain length determinant
Gene
UrdB
Organism
Streptomyces fradiae
Streptomyces roseoflavus
1uniprot[Pubmed] 7592377 [Medline] 96042088
Cloning and characterization of a polyketide synthase from Streptomyces fradiae Tue2717 encoding the genes for biosynthesis of the angucycline antibiotic urdamycin A and a gene probably involved in its oxygenation.(J. Bacteriol.) [1995]
31
 F2RC16_STRVP
(F2RC16)		 
[query] 10 - 404 (415)
[subject] 6 - 400 (404)
 1e-110 404   58%
Product
Polyketide chain length factor
Gene
SVEN_5981
Organism
Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
1uniprot[Pubmed] 21463507
Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes.(BMC Genomics) [2011]
32
 Q54496_STRNO
(Q54496)		 Jump to Nogl_00380 
[query] 10 - 404 (415)
[subject] 6 - 401 (409)
 1e-110 404   57%
Product
Snoa2
Gene
snoa2
Organism
Streptomyces nogalater
1uniprot[Pubmed] 8668120 [Medline] 96242142
A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.(Mol. Gen. Genet.) [1996]
2uniprot[Pubmed] 9349712 [Medline] 98007868
Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.(Mol. Gen. Genet.) [1997]
3uniprot[Pubmed] 8760909 [Medline] 96349102
Production of hybrid anthracycline antibiotics by heterologous expression of Streptomyces nogalater nogalamycin biosynthesis genes.(Microbiology) [1996]
[pubmed all]
33
 B0LJ49_9ACTO
(B0LJ49)		 
[query] 8 - 404 (415)
[subject] 4 - 403 (406)
 1e-110 404   54%
Product
Lcz32
Gene
lcz32
Organism
Streptomyces sanglieri
1uniprot[Pubmed] 18070976
Biosynthetic investigations of lactonamycin and lactonamycin z: cloning of the biosynthetic gene clusters and discovery of an unusual starter unit.(Antimicrob. Agents Chemother.) [2008]
35
 Q56164_9ACTO
(Q56164)		 Jump to Jado_00090 
[query] 10 - 404 (415)
[subject] 6 - 400 (404)
 1e-110 402   57%
Product
Chain length determinant
Gene
 
Organism
Streptomyces venezuelae
1uniprot[Pubmed] 7881555 [Medline] 95187308
Cloning and characterization of polyketide synthase genes for jadomycin B biosynthesis in Streptomyces venezuelae ISP5230.(Microbiology) [1994]
2uniprot
Functional characterization of the jadI gene as a cyclase forming angucyclinones.(J. Am. Chem. Soc.) [1999]
36
 B0LJ15_9ACTO
(B0LJ15)		 
[query] 8 - 404 (415)
[subject] 4 - 403 (406)
 1e-109 400   56%
Product
Lct32
Gene
lct32
Organism
Streptomyces rishiriensis
1uniprot[Pubmed] 18070976
Biosynthetic investigations of lactonamycin and lactonamycin z: cloning of the biosynthetic gene clusters and discovery of an unusual starter unit.(Antimicrob. Agents Chemother.) [2008]
37
 Q93LY3_9ACTO
(Q93LY3)		 
[query] 8 - 404 (415)
[subject] 4 - 401 (405)
 1e-108 398   56%
Product
Chain length determinant PgaB
Gene
pgaB
Organism
Streptomyces sp. PGA64
1uniprot[Pubmed] 12654660 [Medline] 22540650
Engineering anthracycline biosynthesis toward angucyclines.(Antimicrob. Agents Chemother.) [2003]
2uniprot[Pubmed] 15515887
Partial activation of a silent angucycline-type gene cluster from a rubromycin beta producing Streptomyces sp. PGA64.(J. Antibiot.) [2004]
[pubmed all]
38
 Q4U0Y7_9ACTO
(Q4U0Y7)		 
[query] 8 - 404 (415)
[subject] 7 - 404 (408)
 1e-108 397   53%
Product
Type II PKS CLF domain
Gene
 
Organism
Streptomyces nodosus
1uniprot[Pubmed] 16832727
Amplification of DNA encoding entire type I polyketide synthase domains and linkers from streptomyces species.(Curr. Microbiol.) [2006]
39
 Q9AMJ2_STRAT
(Q9AMJ2)		 
[query] 10 - 404 (415)
[subject] 6 - 400 (404)
 1e-107 395   57%
Product
Putative ketosynthase SimA2
Sim3
Gene
simA2
sim3
Organism
Streptomyces antibioticus
1uniprot[Pubmed] 11959542 [Medline] 21955989
Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibiotic.(Antimicrob. Agents Chemother.) [2002]
2uniprot[Pubmed] 12115055 [Medline] 22109063
Cloning and analysis of the simocyclinone biosynthetic gene cluster of Streptomyces antibioticus Tu 6040.(Arch. Microbiol.) [2002]
[pubmed all]
42
 D6MSY2_9ACTO
(D6MSY2)		 
[query] 8 - 404 (415)
[subject] 10 - 408 (412)
 1e-105 386   53%
Product
SsfB
Gene
ssfB
Organism
Streptomyces sp. SF2575
1uniprot[Pubmed] 19908837
Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.(J. Am. Chem. Soc.) [2009]
43
 Q4R0M1_STRCX
(Q4R0M1)		 Jump to Chart_00110 
[query] 8 - 404 (415)
[subject] 4 - 401 (408)
 1e-105 385   57%
Product
ChaB protein
Gene
chaB
Organism
Streptomyces chartreusis
1uniprot[Pubmed] 15911378
Biosynthesis of the antitumor agent chartreusin involves the oxidative rearrangement of an anthracyclic polyketide.(Chem. Biol.) [2005]
45
 Q8VWB2_9ACTO
(Q8VWB2)		 
[query] 10 - 404 (415)
[subject] 6 - 401 (407)
 1e-104 384   55%
Product
AknC
Gene
aknC
Organism
Streptomyces galilaeus
1uniprot[Pubmed] 12399480 [Medline] 22286521
Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus.(J. Bacteriol.) [2002]
46
 Q2MGD0_STRGR
(Q2MGD0)		 Jump to Fred_00090 
[query] 10 - 404 (415)
[subject] 5 - 400 (403)
 1e-104 383   54%
Product
Chain length factor
Gene
 
Organism
Streptomyces griseus
1uniprot[Pubmed] 16305230
Cloning, sequencing, analysis, and heterologous expression of the fredericamycin biosynthetic gene cluster from Streptomyces griseus.(J. Am. Chem. Soc.) [2005]
47
 Q3S8R3_STRRM
(Q3S8R3)		 Jump to Oxtet_00030 
[query] 8 - 407 (415)
[subject] 21 - 421 (422)
 1e-104 383   58%
Product
OxyB
Gene
oxyB
Organism
Streptomyces rimosus
1uniprot[Pubmed] 16597959
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.(Appl. Environ. Microbiol.) [2006]
48
 E2EKK0_9ACTO
(E2EKK0)		 
[query] 7 - 404 (415)
[subject] 23 - 420 (423)
 1e-104 383   53%
Product
Chain length factor
Gene
sanG
Organism
Streptomyces sp. SANK 61196
1uniprot[Pubmed] 20550125
Cloning, sequencing, heterologous expression, and mechanistic analysis of A-74528 biosynthesis.(J. Am. Chem. Soc.) [2010]
50
 Q9L550_9ACTO
(Q9L550)		 Jump to Acla_00080 
[query] 10 - 415 (415)
[subject] 6 - 405 (407)
 1e-104 382   54%
Product
AknC
Gene
aknC
Organism
Streptomyces galilaeus
1uniprot[Pubmed] 12137949 [Medline] 22133312
Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster.(Gene) [2002]
51
 Q6VMI8_STRAM
(Q6VMI8)		 
[query] 10 - 404 (415)
[subject] 6 - 400 (403)
 1e-103 381   58%
Product
Putative chain length determinant
Gene
alpB
DSMT0184
Organism
Streptomyces ambofaciens
1uniprot[Pubmed] 14742212
Functional angucycline-like antibiotic gene cluster in the terminal inverted repeats of the Streptomyces ambofaciens linear chromosome.(Antimicrob. Agents Chemother.) [2004]
2uniprot[Pubmed] 16952952
Intraspecific variability of the terminal inverted repeats of the linear chromosome of Streptomyces ambofaciens.(J. Bacteriol.) [2006]
[pubmed all]
52
 Q1RQS1_STRAM
(Q1RQS1)		 
[query] 10 - 404 (415)
[subject] 6 - 400 (403)
 1e-103 381   58%
Product
Putative chain length determinant
Gene
alpB
SAMT0164
SAMT0165
Organism
Streptomyces ambofaciens ATCC 23877
1uniprot[Pubmed] 16952952
Intraspecific variability of the terminal inverted repeats of the linear chromosome of Streptomyces ambofaciens.(J. Bacteriol.) [2006]
2uniprot[Pubmed] 16956972
Evolution of the terminal regions of the Streptomyces linear chromosome.(Mol. Biol. Evol.) [2006]
3uniprot
Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877.(Microbiology (Mosc.)) [2006]
[pubmed all]
53
 KAS2_STRGA
(P16539)		 
[query] 10 - 408 (415)
[subject] 8 - 409 (409)
 1e-103 380   53%
Product
Tetracenomycin C polyketide putative beta-ketoacyl synthase 2
Gene
tcmL
Organism
Streptomyces glaucescens
1uniprot[Pubmed] 2684656 [Medline] 90060035
Analysis of the nucleotide sequence of the Streptomyces glaucescens tcmI genes provides key information about the enzymology of polyketide antibiotic biosynthesis.(EMBO J.) [1989]
2uniprot[Pubmed] 1592819 [Medline] 92276347
Sequence and transcriptional analysis of the Streptomyces glaucescens tcmAR tetracenomycin C resistance and repressor gene loci.(J. Bacteriol.) [1992]
[pubmed all]
54
 Q54218_STRGR
(Q54218)		 Jump to Griseu_00020 
[query] 1 - 404 (415)
[subject] 1 - 408 (412)
 1e-103 378   53%
Product
Putative chain length determination factor
Gene
 
Organism
Streptomyces griseus
1uniprot[Pubmed] 8169211 [Medline] 94222841
Cloning, sequencing, and analysis of the griseusin polyketide synthase gene cluster from Streptomyces griseus.(J. Bacteriol.) [1994]
55
 Q54815_STRPE
(Q54815)		 Jump to Adria_00280 
[query] 6 - 404 (415)
[subject] 24 - 421 (425)
 1e-102 378   56%
Product
Daunorubicin-doxorubicin polyketide synthase
Gene
dpsB
Organism
Streptomyces peucetius
1uniprot[Pubmed] 7828855 [Medline] 95129838
Characterization of the Streptomyces peucetius ATCC 29050 genes encoding doxorubicin polyketide synthase.(Gene) [1994]
56
 D2SZ00_MICEC
(D2SZ00)		 
[query] 7 - 404 (415)
[subject] 2 - 401 (405)
 1e-102 378   51%
Product
Ketosynthase
Gene
 
Organism
Micromonospora echinospora subsp. challisensis
1uniprot[Pubmed] 19680283
TLN-05220, TLN-05223, new Echinosporamicin-type antibiotics, and proposed revision of the structure of bravomicins(*).(J. Antibiot.) [2009]
57
 C0JWB5_9ACTO
(C0JWB5)		 Jump to Polk_00200 
[query] 10 - 404 (415)
[subject] 5 - 403 (407)
 1e-102 376   54%
Product
PokP2
Gene
pokP2
Organism
Streptomyces diastatochromogenes
1uniprot[Pubmed] 19266534
Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009]
59
 Q55224_STRSQ
(Q55224)		 Jump to Dauno_00170 
[query] 10 - 404 (415)
[subject] 1 - 394 (398)
 1e-101 374   55%
Product
Polyketide synthase
Gene
dauA
Organism
Streptomyces sp
1uniprot[Pubmed] 7928998 [Medline] 95014072
Isolation and sequence analysis of polyketide synthase genes from the daunomycin-producing Streptomyces sp. strain C5.(J. Bacteriol.) [1994]
60
 D1A6R4_THECD
(D1A6R4)		 
[query] 7 - 404 (415)
[subject] 3 - 401 (405)
 1e-101 373   54%
Product
Beta-ketoacyl synthase
Gene
Tcur_2772
Organism
Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
1uniprot
Complete genome sequence of Thermomonospora curvata type strain (B9).(Stand. Genomic Sci.) [2011]
61
 A8KQX7_9ACTO
(A8KQX7)		 Jump to Ello_00120 
[query] 3 - 404 (415)
[subject] 6 - 408 (411)
 1e-101 373   55%
Product
Ketoacyl synthase beta
Gene
elmL
Organism
Streptomyces olivaceus
1uniprot[Pubmed] 18310024
Biosynthesis of elloramycin in Streptomyces olivaceus requires glycosylation by enzymes encoded outside the aglycon cluster.(Microbiology) [2008]
62
 C7PWQ6_CATAD
(C7PWQ6)		 
[query] 4 - 405 (415)
[subject] 26 - 428 (437)
 1e-101 372   55%
Product
Beta-ketoacyl synthase
Gene
Caci_6486
Organism
Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
1uniprot
Complete genome sequence of Catenulispora acidiphila type strain (ID 139908).(Stand. Genomic Sci.) [2009]
63
 D5MRH8_9ACTO
(D5MRH8)		 
[query] 9 - 404 (415)
[subject] 5 - 400 (404)
 1e-100 371   56%
Product
Putative chain length determinant factor
Gene
hrbE
Organism
Streptomyces sp. 2238-SVT4
1uniprot[Pubmed] 20453135
Cloning and characterization of a gene cluster for hatomarubigin biosynthesis in Streptomyces sp. strain 2238-SVT4.(Appl. Environ. Microbiol.) [2010]
64
 Q93LZ7_STRAU
(Q93LZ7)		 
[query] 10 - 404 (415)
[subject] 21 - 416 (420)
 1e-100 370   56%
Product
Chain length factor-like protein
Gene
aur2B
Organism
Streptomyces aureofaciens
1uniprot[Pubmed] 15497441
Cloning and characterization of a new polyketide synthase gene cluster in Streptomyces aureofaciens CCM 3239.(DNA Seq.) [2004]
65
 C7QAF3_CATAD
(C7QAF3)		 
[query] 9 - 410 (415)
[subject] 3 - 403 (403)
 1e-100 369   58%
Product
Beta-ketoacyl synthase
Gene
Caci_3547
Organism
Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
1uniprot
Complete genome sequence of Catenulispora acidiphila type strain (ID 139908).(Stand. Genomic Sci.) [2009]
67
 Q2PA08_9ACTO
(Q2PA08)		 Jump to Stref_00070 
[query] 10 - 407 (415)
[subject] 1 - 399 (406)
 7e-99 365   55%
Product
Chain length factor
Gene
stfK
Organism
Streptomyces steffisburgensis
1uniprot[Pubmed] 16751529
Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin.(Appl. Environ. Microbiol.) [2006]
68
 C7N0D2_SACVD
(C7N0D2)		 
[query] 2 - 404 (415)
[subject] 5 - 408 (411)
 7e-99 365   51%
Product
3-oxoacyl-(Acyl-carrier-protein) synthase
Gene
Svir_33700
Organism
Saccharomonospora viridis (strain ATCC 15386 / DSM 43017 / JCM 3036 / NBRC 12207 / P101)
1uniprot
Complete genome sequence of Saccharomonospora viridis type strain (P101T).(Stand. Genomic Sci.) [2009]
69
 Q53672_STRAA
(Q53672)		 Jump to Mith_00150 
[query] 5 - 404 (415)
[subject] 4 - 404 (408)
 7e-98 362   56%
Product
MtmK protein
Gene
mtmK
Organism
Streptomyces argillaceus
1uniprot[Pubmed] 8654997 [Medline] 96257259
Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144
An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479
Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047
Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478
Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236
Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456
Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776
The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809
Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752
The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297
Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254
Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461
Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994
Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398
Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238
Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589
MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823
Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316
Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873
The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]
[pubmed all]
72
 Q47QL2_THEFY
(Q47QL2)		 
[query] 10 - 404 (415)
[subject] 5 - 399 (402)
 9e-98 362   55%
Product
Actinorhodin polyketide beta-ketoacyl synthase beta subunit / 3-oxoacyl-ACP synthase II
Gene
Tfu_1219
Organism
Thermobifida fusca (strain YX)
1uniprot[Pubmed] 17209016
Genome sequence and analysis of the soil cellulolytic actinomycete Thermobifida fusca YX.(J. Bacteriol.) [2007]
75
 B1GSN2_9ACTO
(B1GSN2)		 Jump to Bena_00100 
[query] 10 - 404 (415)
[subject] 3 - 399 (409)
 2e-96 357   51%
Product
BenB protein
Gene
benB
Organism
Streptomyces sp. A2991200
1uniprot[Pubmed] 17439117
Molecular analysis of the benastatin biosynthetic pathway and genetic engineering of altered fatty acid-polyketide hybrids.(J. Am. Chem. Soc.) [2007]
76
 Q2PZR8_9ACTO
(Q2PZR8)		 Jump to Cosmo_00080 
[query] 10 - 404 (415)
[subject] 5 - 395 (414)
 4e-96 356   56%
Product
CosC
Gene
cosC
Organism
Streptomyces olindensis
1uniprot[Pubmed] 16810496
Insights in the glycosylation steps during biosynthesis of the antitumor anthracycline cosmomycin: characterization of two glycosyltransferase genes.(Appl. Microbiol. Biotechnol.) [2006]
77
 D7RFJ6_AMYOR
(D7RFJ6)		 
[query] 10 - 404 (415)
[subject] 22 - 414 (423)
 6e-96 355   56%
Product
Putative ketosynthase beta subunit
Gene
bexB
Organism
Amycolatopsis orientalis subsp. vinearia
1uniprot[Pubmed] 20443562
A biosynthetic pathway for BE-7585A, a 2-thiosugar-containing angucycline-type natural product.(J. Am. Chem. Soc.) [2010]
79
 Q93HA1_STRAW
(Q93HA1)		 
[query] 2 - 405 (415)
[subject] 12 - 414 (416)
 4e-95 353   51%
Product
3-oxoacyl-(Acyl carrier protein) synthase II
Putative 3-oxoacyl-ACP synthase II
Gene
pks9-3
SAV2375
SAV_2375
Organism
Streptomyces avermitilis
1uniprot[Pubmed] 11572948 [Medline] 21477403
Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.(Proc. Natl. Acad. Sci. U.S.A.) [2001]
2uniprot[Pubmed] 12692562 [Medline] 22608306
Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis.(Nat. Biotechnol.) [2003]
[pubmed all]
80
 O32452_9ACTO
(O32452)		 
[query] 11 - 410 (415)
[subject] 11 - 406 (407)
 6e-94 349   54%
Product
ORF 2
Gene
 
Organism
Actinomadura hibisca
1uniprot[Pubmed] 9339544 [Medline] 97480928
Cloning and nucleotide sequence of the putative polyketide synthase genes for pradimicin biosynthesis from Actinomadura hibisca.(Biosci. Biotechnol. Biochem.) [1997]
81
 D8I4M0_AMYMU
(D8I4M0)		 
[query] 10 - 405 (415)
[subject] 15 - 405 (406)
 6e-94 349   51%
Product
3-oxoacyl-[acyl-carrier-protein] synthase II
Gene
fabF
AMED_5434
Organism
Amycolatopsis mediterranei (strain U-32)
1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]
82
 D9UBT0_STRPR
(D9UBT0)		 
[query] 2 - 405 (415)
[subject] 21 - 421 (427)
 1e-93 348   55%
Product
Putative ketoacylsynthase, chain length factor beta-subunit
Gene
cpp4
Organism
Streptomyces pristinaespiralis
1uniprot[Pubmed] 21342465
Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011]
83
 D7BZR0_STRBB
(D7BZR0)		 
[query] 9 - 405 (415)
[subject] 6 - 407 (412)
 3e-92 343   56%
Product
Beta-ketoacyl synthase
Gene
SBI_06845
Organism
Streptomyces bingchenggensis (strain BCW-1)
1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]
85
 F4FBT6_VERMA
(F4FBT6)		 
[query] 9 - 405 (415)
[subject] 4 - 401 (402)
 1e-91 341   54%
Product
3-oxoacyl-(Acyl-carrier-protein) synthase
Gene
VAB18032_18170
Organism
Verrucosispora maris (strain AB-18-032)
1uniprot[Pubmed] 21551311
Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.(J. Bacteriol.) [2011]
89
 Q9XDZ9_9ACTO
(Q9XDZ9)		 
[query] 10 - 410 (415)
[subject] 27 - 427 (460)
 1e-90 338   55%
Product
Polyketide synthase
Gene
 
Organism
Actinomadura verrucosospora
1uniprot[Pubmed] 10347064 [Medline] 99278093
Development of a self-cloning system for Actinomadura verrucosospora and identification of polyketide synthase genes essential for production of the angucyclic antibiotic pradimicin.(Appl. Environ. Microbiol.) [1999]
91
 A7DWI8_STRTE
(A7DWI8)		 
[query] 1 - 409 (415)
[subject] 1 - 406 (414)
 2e-89 333   51%
Product
Putative beta-ketoacyl synthase beta (CLF)
Gene
llpE
Organism
Streptomyces tendae
1uniprot
Isolation of the lysolipin gene cluster of Streptomyces tendae Tu 4042.(Gene) [2010]
92
 D2AY45_STRRD
(D2AY45)		 
[query] 7 - 405 (415)
[subject] 3 - 403 (406)
 1e-88 332   53%
Product
3-oxoacyl-(Acyl-carrier-protein) synthase II
Gene
Sros_4151
Organism
Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
1uniprot
Complete genome sequence of Streptosporangium roseum type strain (NI 9100T).(Stand. Genomic Sci.) [2010]
93
 Q0RHJ8_FRAAA
(Q0RHJ8)		 
[query] 8 - 404 (415)
[subject] 26 - 426 (432)
 2e-86 324   49%
Product
Putative polyketide beta-ketoacyl synthase 2 (Pks family)
Gene
FRAAL4386
Organism
Frankia alni (strain ACN14a)
1uniprot[Pubmed] 17151343
Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007]
95
 Q83X36_STRRO
(Q83X36)		 
[query] 6 - 404 (415)
[subject] 14 - 412 (416)
 2e-84 318   55%
Product
Beta-ketoacyl synthase beta-subunit (Chain length factor)
Gene
rocB
Organism
Streptomyces rochei
Streptomyces parvullus
1uniprot[Pubmed] 12791134 [Medline] 22676866
The large linear plasmid pSLA2-L of Streptomyces rochei has an unusually condensed gene organization for secondary metabolism.(Mol. Microbiol.) [2003]
2uniprot[Pubmed] 10954087 [Medline] 20408175
Cloning and analysis of the replication origin and the telomeres of the large linear plasmid pSLA2-L in Streptomyces rochei.(Mol. Gen. Genet.) [2000]
3uniprot[Pubmed] 10767533 [Medline] 20231737
Identification of two polyketide synthase gene clusters on the linear plasmid pSLA2-L in Streptomyces rochei.(Gene) [2000]
4uniprot[Pubmed] 9836424 [Medline] 99053144
Physical mapping of the linear plasmid pSLA2-L and localization of the eryAI and actI homologs.(Biosci. Biotechnol. Biochem.) [1998]
[pubmed all]
96
 KAS2_STRCM
(P41176)		 
[query] 11 - 404 (415)
[subject] 6 - 398 (402)
 7e-83 312   52%
Product
Putative polyketide beta-ketoacyl synthase 2
ORF 2
Gene
 
Organism
Streptomyces cinnamonensis
1uniprot[Pubmed] 1508151 [Medline] 92374994
Characterisation of actI-homologous DNA encoding polyketide synthase genes from the monensin producer Streptomyces cinnamonensis.(Mol. Gen. Genet.) [1992]
98
 Q54995_9ACTO
(Q54995)		 Jump to Fren_00130 
[query] 10 - 401 (415)
[subject] 21 - 414 (426)
 5e-82 309   55%
Product
Chain length factor
Gene
frnM
Organism
Streptomyces roseofulvus
1uniprot[Pubmed] 8181754 [Medline] 94237486
Cloning, sequencing and deduced functions of a cluster of Streptomyces genes probably encoding biosynthesis of the polyketide antibiotic frenolicin.(Gene) [1994]
99
 Q8KSW3_9ACTO
(Q8KSW3)		 Jump to Griseo_00290 
[query] 6 - 404 (415)
[subject] 11 - 410 (420)
 1e-81 308   49%
Product
Putative ketosynthase beta GrhB
Gene
grhB
Organism
Streptomyces sp. JP95
1uniprot[Pubmed] 12323376 [Medline] 22235582
A gene cluster from a marine Streptomyces encoding the biosynthesis of the aromatic spiroketal polyketide griseorhodin A.(Chem. Biol.) [2002]
100
 Q9RHT7_STRRO
(Q9RHT7)		 
[query] 6 - 404 (415)
[subject] 14 - 411 (415)
 4e-81 306   52%
Product
Chain length factor
Gene
orf2
Organism
Streptomyces rochei
Streptomyces parvullus
1uniprot[Pubmed] 10767533 [Medline] 20231737
Identification of two polyketide synthase gene clusters on the linear plasmid pSLA2-L in Streptomyces rochei.(Gene) [2000]