| accession | DB | alignment | Evalue | Score | Ident. | link | information | pubmed |
1
|
Q9KHL3_9ACTO (Q9KHL3) |
|
|
1e-161 |
571 |
100% |
|
- Product
- Putative transcriptional regulator EncF
- Gene
- encF
- Organism
- Streptomyces maritimus
|
1uniprot Natural Metabolic Diversity Encoded by the Enterocin Biosynthesis Gene Cluster.(J. Am. Chem. Soc.) [2000] | 2uniprot[Pubmed] 11137817 [Medline] 20579517 Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate 'Streptomyces maritimus': evidence for the derailment of an aromatic polyketide synthase.(Chem. Biol.) [2000] | 3uniprot[Pubmed] 11948863 [Medline] 21942282 A mechanism of benzoic acid biosynthesis in plants and bacteria that mirrors fatty acid beta-oxidation.(Chembiochem) [2001] | [pubmed all]
|
2
|
D1A6U2_THECD (D1A6U2) |
|
|
2e-58 |
230 |
47% |
|
- Product
- Transcriptional regulator, SARP family
- Gene
- Tcur_2801
- Organism
- Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
|
1uniprot Complete genome sequence of Thermomonospora curvata type strain (B9).(Stand. Genomic Sci.) [2011] |
|
5
|
Q2L6C8_9ACTO (Q2L6C8) |
|
|
1e-55 |
221 |
46% |
|
- Product
- Putative transcriptional regulator
- Gene
-
- Organism
- Streptomyces sp. KO-3988
|
1uniprot[Pubmed] 16452404 Biosynthesis of a natural polyketide-isoprenoid hybrid compound, furaquinocin A: identification and heterologous expression of the gene cluster.(J. Bacteriol.) [2006] |
|
6
|
Q83X33_STRRO (Q83X33) |
|
|
1e-54 |
218 |
46% |
|
- Product
- SARP family regulator SrrZ
- Gene
- srrZ
- Organism
- Streptomyces rochei
Streptomyces parvullus
|
1uniprot[Pubmed] 12791134 [Medline] 22676866 The large linear plasmid pSLA2-L of Streptomyces rochei has an unusually condensed gene organization for secondary metabolism.(Mol. Microbiol.) [2003] | 2uniprot[Pubmed] 10954087 [Medline] 20408175 Cloning and analysis of the replication origin and the telomeres of the large linear plasmid pSLA2-L in Streptomyces rochei.(Mol. Gen. Genet.) [2000] | 3uniprot[Pubmed] 10767533 [Medline] 20231737 Identification of two polyketide synthase gene clusters on the linear plasmid pSLA2-L in Streptomyces rochei.(Gene) [2000] | 4uniprot[Pubmed] 9836424 [Medline] 99053144 Physical mapping of the linear plasmid pSLA2-L and localization of the eryAI and actI homologs.(Biosci. Biotechnol. Biochem.) [1998] | [pubmed all]
|
7
|
D2SZ12_MICEC (D2SZ12) |
|
|
1e-54 |
218 |
46% |
|
- Product
- Transcriptional regulator
- Gene
-
- Organism
- Micromonospora echinospora subsp. challisensis
|
1uniprot[Pubmed] 19680283 TLN-05220, TLN-05223, new Echinosporamicin-type antibiotics, and proposed revision of the structure of bravomicins(*).(J. Antibiot.) [2009] |
|
8
|
A2AXE3_STRCM (A2AXE3) |
|
|
2e-54 |
217 |
43% |
|
- Product
- Putative SARP family pathway-specific regulator
- Gene
- fnq4
- Organism
- Streptomyces cinnamonensis
|
1uniprot[Pubmed] 17103476 A gene cluster for prenylated naphthoquinone and prenylated phenazine biosynthesis in Streptomyces cinnamonensis DSM 1042.(Chembiochem) [2006] |
|
10
|
D9UBT4_STRPR (D9UBT4) |
|
|
7e-54 |
215 |
48% |
|
- Product
- SARP-type regulator
- Gene
- cpp1
- Organism
- Streptomyces pristinaespiralis
|
1uniprot[Pubmed] 21342465 Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011] |
|
11
|
Q9L4V0_9ACTO (Q9L4V0) |
|
|
9e-54 |
214 |
47% |
|
- Product
- Putative activator
- Gene
- aknO
- Organism
- Streptomyces galilaeus
|
1uniprot[Pubmed] 11016846 [Medline] 20469061 A gene cluster from Streptomyces galilaeus involved in glycosylation of aclarubicin.(Mol. Gen. Genet.) [2000] |
|
12
|
E1ARL7_STRAU (E1ARL7) |
|
|
1e-53 |
214 |
45% |
|
- Product
- Putative SARP family pathway specific regulatory protein
- Gene
- sa35
- Organism
- Streptomyces aureofaciens
|
1uniprot[Pubmed] 21393365 The role of two SARP family transcriptional regulators in regulation of the auricin gene cluster in Streptomyces aureofaciens CCM 3239.(Microbiology) [2011] |
|
13
|
B5UAT1_STRLA (B5UAT1) |
|
|
7e-53 |
212 |
45% |
|
- Product
- SARP family regulator
- Gene
- farR3
- Organism
- Streptomyces lavendulae
|
1uniprot Identification of genes involved in the butyrolactone autoregulator cascade that modulates secondary metabolism in Streptomyces lavendulae FRI-5.(Gene) [2008] |
|
16
|
D7BZQ7_STRBB (D7BZQ7) |
|
|
2e-52 |
210 |
47% |
|
- Product
- SARP family pathway specific regulatory protein
- Gene
- SBI_06842
- Organism
- Streptomyces bingchenggensis (strain BCW-1)
|
1uniprot[Pubmed] 20581206 Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010] |
|
17
|
D7CHH7_STRBB (D7CHH7) |
|
|
3e-52 |
209 |
45% |
|
- Product
- SARP family pathway specific regulatory protein
- Gene
- SBI_03913
- Organism
- Streptomyces bingchenggensis (strain BCW-1)
|
1uniprot[Pubmed] 20581206 Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010] |
|
18
|
Q6VMH5_STRAM (Q6VMH5) |
|
|
7e-52 |
208 |
45% |
|
- Product
- Putative SARP family pathway specific regulatory protein
- Gene
- alpT
- Organism
- Streptomyces ambofaciens
|
1uniprot[Pubmed] 14742212 Functional angucycline-like antibiotic gene cluster in the terminal inverted repeats of the Streptomyces ambofaciens linear chromosome.(Antimicrob. Agents Chemother.) [2004] |
|
19
|
Q1RQQ6_STRAM (Q1RQQ6) |
|
|
7e-52 |
208 |
45% |
|
- Product
- Putative SARP family pathway specific regulatory protein
- Gene
- alpT
SAMT0179 SAMT0180
- Organism
- Streptomyces ambofaciens ATCC 23877
|
1uniprot[Pubmed] 16952952 Intraspecific variability of the terminal inverted repeats of the linear chromosome of Streptomyces ambofaciens.(J. Bacteriol.) [2006] | 2uniprot[Pubmed] 16956972 Evolution of the terminal regions of the Streptomyces linear chromosome.(Mol. Biol. Evol.) [2006] | 3uniprot Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877.(Microbiology (Mosc.)) [2006] | [pubmed all]
|
20
|
Q8KSZ0_9ACTO (Q8KSZ0) |
|
|
1e-51 |
208 |
44% |
|
- Product
- Putative transcriptional activator GrhR2
- Gene
- grhR2
- Organism
- Streptomyces sp. JP95
|
1uniprot[Pubmed] 12323376 [Medline] 22235582 A gene cluster from a marine Streptomyces encoding the biosynthesis of the aromatic spiroketal polyketide griseorhodin A.(Chem. Biol.) [2002] |
|
22
|
Q9KWX4_STRAM (Q9KWX4) |
|
|
2e-51 |
206 |
45% |
|
- Product
- Regulator (SAR)
- Gene
- sar
- Organism
- Streptomyces ambofaciens
|
1uniprot[Pubmed] 10628855 [Medline] 20092477 Cloning and characterization of a regulatory gene of the SARP family and its flanking region from Streptomyces ambofaciens.(Mol. Gen. Genet.) [1999] |
|
25
|
D9UBV4_STRPR (D9UBV4) |
|
|
3e-51 |
206 |
44% |
|
- Product
- SARP-type regulator
- Gene
- papR1
- Organism
- Streptomyces pristinaespiralis
|
1uniprot[Pubmed] 21342465 Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011] |
|
27
|
D7CH46_STRBB (D7CH46) |
|
|
5e-51 |
205 |
47% |
|
- Product
- Transcriptional regulator, SARP family protein
- Gene
- SBI_01760
- Organism
- Streptomyces bingchenggensis (strain BCW-1)
|
1uniprot[Pubmed] 20581206 Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010] |
|
28
|
Q0JW85_STRAM (Q0JW85) |
|
|
6e-51 |
205 |
45% |
|
- Product
- Putative SARP family pathway specific regulatory protein
- Gene
- DSMT0201
- Organism
- Streptomyces ambofaciens
|
1uniprot[Pubmed] 16952952 Intraspecific variability of the terminal inverted repeats of the linear chromosome of Streptomyces ambofaciens.(J. Bacteriol.) [2006] |
|
29
|
Q6VMH3_STRAM (Q6VMH3) |
|
|
7e-51 |
205 |
45% |
|
- Product
- Putative SARP family pathway specific regulatory protein
- Gene
- alpV
- Organism
- Streptomyces ambofaciens
|
1uniprot[Pubmed] 14742212 Functional angucycline-like antibiotic gene cluster in the terminal inverted repeats of the Streptomyces ambofaciens linear chromosome.(Antimicrob. Agents Chemother.) [2004] |
|
30
|
Q1RQQ4_STRAM (Q1RQQ4) |
|
|
7e-51 |
205 |
45% |
|
- Product
- Putative SARP family pathway specific regulatory protein
- Gene
- alpV
SAMT0181 SAMT0182
- Organism
- Streptomyces ambofaciens ATCC 23877
|
1uniprot[Pubmed] 16952952 Intraspecific variability of the terminal inverted repeats of the linear chromosome of Streptomyces ambofaciens.(J. Bacteriol.) [2006] | 2uniprot[Pubmed] 16956972 Evolution of the terminal regions of the Streptomyces linear chromosome.(Mol. Biol. Evol.) [2006] | 3uniprot Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877.(Microbiology (Mosc.)) [2006] | [pubmed all]
|
31
|
Q9XCC4_STRFR (Q9XCC4) |
|
|
8e-51 |
205 |
45% |
|
- Product
- Hypothetical pathway specific regulatory protein TylS
- Gene
- tylS
- Organism
- Streptomyces fradiae
Streptomyces roseoflavus
|
1uniprot[Pubmed] 10467127 [Medline] 99398833 Multiple regulatory genes in the tylosin biosynthetic cluster of Streptomyces fradiae.(Chem. Biol.) [1999] |
|
32
|
Q0JW87_STRAM (Q0JW87) |
|
|
8e-51 |
205 |
45% |
|
- Product
- Putative SARP family pathway specific regulatory protein
- Gene
- DSMT0199
- Organism
- Streptomyces ambofaciens
|
1uniprot[Pubmed] 16952952 Intraspecific variability of the terminal inverted repeats of the linear chromosome of Streptomyces ambofaciens.(J. Bacteriol.) [2006] |
|
34
|
E2Q9D3_STRCL (E2Q9D3) |
|
|
1e-50 |
204 |
46% |
|
- Product
- SARP family pathway specific regulatory protein
- Gene
- SCLAV_0477
- Organism
- Streptomyces clavuligerus ATCC 27064
|
1uniprot[Pubmed] 20624727 The sequence of a 1.8-mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.(Genome Biol. Evol.) [2010] |
|
35
|
Q67G41_9ACTO (Q67G41) |
|
|
1e-50 |
204 |
45% |
|
- Product
- Putative regulatory protein
- Gene
-
- Organism
- Streptomyces griseoruber
|
1uniprot[Pubmed] 15271354 The hedamycin locus implicates a novel aromatic PKS priming mechanism.(Chem. Biol.) [2004] |
|
36
|
Q83X49_STRRO (Q83X49) |
|
|
1e-50 |
204 |
46% |
|
- Product
- SARP family regulator SrrW
- Gene
- srrW
- Organism
- Streptomyces rochei
Streptomyces parvullus
|
1uniprot[Pubmed] 12791134 [Medline] 22676866 The large linear plasmid pSLA2-L of Streptomyces rochei has an unusually condensed gene organization for secondary metabolism.(Mol. Microbiol.) [2003] | 2uniprot[Pubmed] 10954087 [Medline] 20408175 Cloning and analysis of the replication origin and the telomeres of the large linear plasmid pSLA2-L in Streptomyces rochei.(Mol. Gen. Genet.) [2000] | 3uniprot[Pubmed] 10767533 [Medline] 20231737 Identification of two polyketide synthase gene clusters on the linear plasmid pSLA2-L in Streptomyces rochei.(Gene) [2000] | 4uniprot[Pubmed] 9836424 [Medline] 99053144 Physical mapping of the linear plasmid pSLA2-L and localization of the eryAI and actI homologs.(Biosci. Biotechnol. Biochem.) [1998] | [pubmed all]
|
37
|
A7DWL6_STRTE (A7DWL6) |
|
|
1e-50 |
204 |
45% |
|
- Product
- Putative transcriptional activator, SARP family
- Gene
- llpRIV
- Organism
- Streptomyces tendae
|
1uniprot Isolation of the lysolipin gene cluster of Streptomyces tendae Tu 4042.(Gene) [2010] |
|
38
|
C9ZCD2_STRSW (C9ZCD2) |
|
|
1e-50 |
204 |
45% |
|
- Product
- Putative regulatory protein
- Gene
- SCAB_63171
- Organism
- Streptomyces scabies (strain 87.22)
Streptomyces scabiei
|
1uniprot[Pubmed] 20064060 Streptomyces scabies 87-22 contains a coronafacic acid-like biosynthetic cluster that contributes to plant-microbe interactions.(Mol. Plant Microbe Interact.) [2010] |
|
39
|
E1ARL5_STRAU (E1ARL5) |
|
|
2e-50 |
203 |
43% |
|
- Product
- Putative SARP family pathway specific regulatory protein
- Gene
- sa37
- Organism
- Streptomyces aureofaciens
|
1uniprot[Pubmed] 21393365 The role of two SARP family transcriptional regulators in regulation of the auricin gene cluster in Streptomyces aureofaciens CCM 3239.(Microbiology) [2011] |
|
42
|
Q4R0M3_STRCX (Q4R0M3) |
|
|
1e-49 |
201 |
48% |
|
- Product
- ChaR1 protein
- Gene
- chaR1
- Organism
- Streptomyces chartreusis
|
1uniprot[Pubmed] 15911378 Biosynthesis of the antitumor agent chartreusin involves the oxidative rearrangement of an anthracyclic polyketide.(Chem. Biol.) [2005] |
|
43
|
E4NBI0_KITSK (E4NBI0) |
|
|
1e-49 |
201 |
44% |
|
- Product
- Putative AfsR family transcriptional regulator
- Gene
- KSE_27490
- Organism
- Kitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054)
Streptomyces setae
|
1uniprot[Pubmed] 21059706 Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary snapshot of the family Streptomycetaceae.(DNA Res.) [2010] |
|
45
|
O68913_9ACTO (O68913) |
|
|
2e-49 |
200 |
46% |
|
- Product
- Pathway specific regulator
- Gene
- frnG
- Organism
- Streptomyces roseofulvus
|
1uniprot[Pubmed] 8181754 [Medline] 94237486 Cloning, sequencing and deduced functions of a cluster of Streptomyces genes probably encoding biosynthesis of the polyketide antibiotic frenolicin.(Gene) [1994] |
|
47
|
E2EKL8_9ACTO (E2EKL8) |
|
|
4e-49 |
199 |
44% |
|
- Product
- Regulator
- Gene
- sanR1
- Organism
- Streptomyces sp. SANK 61196
|
1uniprot[Pubmed] 20550125 Cloning, sequencing, heterologous expression, and mechanistic analysis of A-74528 biosynthesis.(J. Am. Chem. Soc.) [2010] |
|
49
|
Q9LBV5_STRVG (Q9LBV5) |
|
|
4e-49 |
199 |
43% |
|
- Product
- Orf2
- Gene
-
- Organism
- Streptomyces virginiae
|
1uniprot[Pubmed] 10792718 [Medline] 20253310 Identification of an AfsA homologue (BarX) from Streptomyces virginiae as a pleiotropic regulator controlling autoregulator biosynthesis, virginiamycin biosynthesis and virginiamycin M1 resistance.(Mol. Microbiol.) [2000] |
|
50
|
B5UAT2_STRLA (B5UAT2) |
|
|
4e-49 |
199 |
44% |
|
- Product
- SARP family regulator
- Gene
- farR4
- Organism
- Streptomyces lavendulae
|
1uniprot Identification of genes involved in the butyrolactone autoregulator cascade that modulates secondary metabolism in Streptomyces lavendulae FRI-5.(Gene) [2008] |
|
52
|
Q83X29_STRRO (Q83X29) |
|
|
1e-48 |
197 |
43% |
|
- Product
- SARP family regulator SrrY
- Gene
- srrY
- Organism
- Streptomyces rochei
Streptomyces parvullus
|
1uniprot[Pubmed] 12791134 [Medline] 22676866 The large linear plasmid pSLA2-L of Streptomyces rochei has an unusually condensed gene organization for secondary metabolism.(Mol. Microbiol.) [2003] | 2uniprot[Pubmed] 10954087 [Medline] 20408175 Cloning and analysis of the replication origin and the telomeres of the large linear plasmid pSLA2-L in Streptomyces rochei.(Mol. Gen. Genet.) [2000] | 3uniprot[Pubmed] 10767533 [Medline] 20231737 Identification of two polyketide synthase gene clusters on the linear plasmid pSLA2-L in Streptomyces rochei.(Gene) [2000] | 4uniprot[Pubmed] 9836424 [Medline] 99053144 Physical mapping of the linear plasmid pSLA2-L and localization of the eryAI and actI homologs.(Biosci. Biotechnol. Biochem.) [1998] | [pubmed all]
|
53
|
Q2PA02_9ACTO (Q2PA02) |
|
|
7e-48 |
195 |
42% |
|
- Product
- SARP family regulator
- Gene
- stfRI
- Organism
- Streptomyces steffisburgensis
|
1uniprot[Pubmed] 16751529 Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin.(Appl. Environ. Microbiol.) [2006] |
|
54
|
D9UBW9_STRPR (D9UBW9) |
|
|
1e-47 |
194 |
41% |
|
- Product
- SARP-type regulator
- Gene
- papR4
- Organism
- Streptomyces pristinaespiralis
|
1uniprot[Pubmed] 21342465 Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011] |
|
56
|
D8I4K7_AMYMU (D8I4K7) |
|
|
3e-47 |
193 |
40% |
|
- Product
- SARP family transcriptional regulator
- Gene
- AMED_5421
- Organism
- Amycolatopsis mediterranei (strain U-32)
|
1uniprot[Pubmed] 20567260 Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010] |
|
57
|
DNRI_STRPE (P25047) |
|
|
4e-47 |
192 |
43% |
|
- Product
- Regulatory protein dnrI
- Gene
- dnrI
- Organism
- Streptomyces peucetius
|
1uniprot[Pubmed] 1729206 [Medline] 92104954 Regulation of secondary metabolism in Streptomyces spp. and overproduction of daunorubicin in Streptomyces peucetius.(J. Bacteriol.) [1992] |
|
58
|
Q9L545_9ACTO (Q9L545) |
|
|
1e-46 |
191 |
42% |
|
- Product
- AknI
- Gene
- aknI
- Organism
- Streptomyces galilaeus
|
1uniprot[Pubmed] 12137949 [Medline] 22133312 Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster.(Gene) [2002] |
|
59
|
E1ARN0_STRAU (E1ARN0) |
|
|
1e-46 |
191 |
43% |
|
- Product
- SARP family pathway specific regulatory protein
- Gene
- sa24
- Organism
- Streptomyces aureofaciens
|
1uniprot[Pubmed] 21393365 The role of two SARP family transcriptional regulators in regulation of the auricin gene cluster in Streptomyces aureofaciens CCM 3239.(Microbiology) [2011] |
|
62
|
Q8VWA7_9ACTO (Q8VWA7) |
|
|
2e-46 |
190 |
42% |
|
- Product
- AclI
- Gene
- aclI
- Organism
- Streptomyces galilaeus
|
1uniprot[Pubmed] 12399480 [Medline] 22286521 Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus.(J. Bacteriol.) [2002] |
|
64
|
Q2MGB3_STRGR (Q2MGB3) |
|
|
3e-46 |
190 |
45% |
|
- Product
- Regulatory protein
- Gene
-
- Organism
- Streptomyces griseus
|
1uniprot[Pubmed] 16305230 Cloning, sequencing, analysis, and heterologous expression of the fredericamycin biosynthetic gene cluster from Streptomyces griseus.(J. Am. Chem. Soc.) [2005] |
|
65
|
B0LIZ8_9ACTO (B0LIZ8) |
|
|
4e-46 |
189 |
42% |
|
- Product
- Lct15
- Gene
- lct15
- Organism
- Streptomyces rishiriensis
|
1uniprot[Pubmed] 18070976 Biosynthetic investigations of lactonamycin and lactonamycin z: cloning of the biosynthetic gene clusters and discovery of an unusual starter unit.(Antimicrob. Agents Chemother.) [2008] |
|
67
|
C0JWC2_9ACTO (C0JWC2) |
|
|
1e-45 |
187 |
45% |
|
- Product
- PokR2
- Gene
- pokR2
- Organism
- Streptomyces diastatochromogenes
|
1uniprot[Pubmed] 19266534 Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009] |
|
68
|
C7N0E0_SACVD (C7N0E0) |
|
|
1e-45 |
187 |
44% |
|
- Product
- DNA-binding transcriptional activator of the SARP family
- Gene
- Svir_33780
- Organism
- Saccharomonospora viridis (strain ATCC 15386 / DSM 43017 / JCM 3036 / NBRC 12207 / P101)
|
1uniprot Complete genome sequence of Saccharomonospora viridis type strain (P101T).(Stand. Genomic Sci.) [2009] |
|
69
|
Q8KSZ1_9ACTO (Q8KSZ1) |
|
|
2e-45 |
187 |
41% |
|
- Product
- Putative transcriptional activator GrhR1
- Gene
- grhR1
- Organism
- Streptomyces sp. JP95
|
1uniprot[Pubmed] 12323376 [Medline] 22235582 A gene cluster from a marine Streptomyces encoding the biosynthesis of the aromatic spiroketal polyketide griseorhodin A.(Chem. Biol.) [2002] |
|
71
|
E1ARN1_STRAU (E1ARN1) |
|
|
7e-45 |
185 |
40% |
|
- Product
- Putative SARP family pathway specific regulatory protein
- Gene
- sa23
- Organism
- Streptomyces aureofaciens
|
1uniprot[Pubmed] 21393365 The role of two SARP family transcriptional regulators in regulation of the auricin gene cluster in Streptomyces aureofaciens CCM 3239.(Microbiology) [2011] |
|
72
|
C9ZCB7_STRSW (C9ZCB7) |
|
|
9e-45 |
185 |
44% |
|
- Product
- Putative transcriptional activator
- Gene
- SCAB_63021
- Organism
- Streptomyces scabies (strain 87.22)
Streptomyces scabiei
|
1uniprot[Pubmed] 20064060 Streptomyces scabies 87-22 contains a coronafacic acid-like biosynthetic cluster that contributes to plant-microbe interactions.(Mol. Plant Microbe Interact.) [2010] |
|
74
|
E5DUG1_9NOCA (E5DUG1) |
|
|
1e-44 |
184 |
40% |
|
- Product
- NocP
- Gene
- nocP
- Organism
- Nocardia sp. ATCC 202099
|
1uniprot[Pubmed] 20473441 Moving posttranslational modifications forward to biosynthesize the glycosylated thiopeptide nocathiacin I in Nocardia sp. ATCC202099.(Mol. Biosyst.) [2010] |
|
76
|
B6SEG7_9ACTO (B6SEG7) |
|
|
2e-44 |
184 |
42% |
|
- Product
- AlnR3 SARP family regulator
- Gene
- alnR3
- Organism
- Streptomyces sp. CM020
|
1uniprot[Pubmed] 18940666 Characterization of the alnumycin gene cluster reveals unusual gene products for pyran ring formation and dioxan biosynthesis.(Chem. Biol.) [2008] |
|
77
|
B1GSM4_9ACTO (B1GSM4) |
|
|
6e-44 |
182 |
42% |
|
- Product
- BenR protein
- Gene
- benR
- Organism
- Streptomyces sp. A2991200
|
1uniprot[Pubmed] 17439117 Molecular analysis of the benastatin biosynthetic pathway and genetic engineering of altered fatty acid-polyketide hybrids.(J. Am. Chem. Soc.) [2007] |
|
78
|
D2AY68_STRRD (D2AY68) |
|
|
9e-44 |
181 |
42% |
|
- Product
- Transcriptional regulator, SARP family
- Gene
- Sros_4174
- Organism
- Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
|
1uniprot Complete genome sequence of Streptosporangium roseum type strain (NI 9100T).(Stand. Genomic Sci.) [2010] |
|
82
|
Q0RTT8_FRAAA (Q0RTT8) |
|
|
9e-43 |
178 |
43% |
|
- Product
- Activator protein
- Gene
- FRAAL0334
- Organism
- Frankia alni (strain ACN14a)
|
1uniprot[Pubmed] 17151343 Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007] |
|
84
|
Q194R8_STRAA (Q194R8) |
|
|
2e-42 |
177 |
39% |
|
- Product
- Mithramycin regulator MtmR
- Gene
- mtmR
- Organism
- Streptomyces argillaceus
|
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996] | 2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996] | 3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997] | 4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998] | 5uniprot[Pubmed] 9882681 [Medline] 99102230 The mithramycin gene cluster of Streptomyces argillaceus contains a positive regulatory gene and two repeated DNA sequences that are located at both ends of the cluster.(J. Bacteriol.) [1999] | 6uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999] | 7uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999] | 8uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000] | 9uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001] | 10uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003] | 11uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999] | 12uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002] | 13uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000] | 14uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000] | 15uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002] | 16uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003] | 17uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996] | 18uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004] | 19uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997] | 20uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005] | 21uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000] | [pubmed all]
|
86
|
Q54494_STRNO (Q54494) |
|
|
7e-42 |
175 |
40% |
|
- Product
- Snora
- Gene
- snorA
- Organism
- Streptomyces nogalater
|
1uniprot[Pubmed] 8668120 [Medline] 96242142 A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.(Mol. Gen. Genet.) [1996] | 2uniprot[Pubmed] 9349712 [Medline] 98007868 Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.(Mol. Gen. Genet.) [1997] | 3uniprot[Pubmed] 8760909 [Medline] 96349102 Production of hybrid anthracycline antibiotics by heterologous expression of Streptomyces nogalater nogalamycin biosynthesis genes.(Microbiology) [1996] | [pubmed all]
|
88
|
B0LJ06_9ACTO (B0LJ06) |
|
|
2e-41 |
174 |
42% |
|
- Product
- Lct23
- Gene
- lct23
- Organism
- Streptomyces rishiriensis
|
1uniprot[Pubmed] 18070976 Biosynthetic investigations of lactonamycin and lactonamycin z: cloning of the biosynthetic gene clusters and discovery of an unusual starter unit.(Antimicrob. Agents Chemother.) [2008] |
|
92
|
E2Q9B8_STRCL (E2Q9B8) |
|
|
9e-41 |
171 |
42% |
|
- Product
- Putative regulatory protein AfsR-like protein
- Gene
- SCLAV_0462
- Organism
- Streptomyces clavuligerus ATCC 27064
|
1uniprot[Pubmed] 20624727 The sequence of a 1.8-mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.(Genome Biol. Evol.) [2010] |
|
93
|
E2D2K1_9BACT (E2D2K1) |
|
|
2e-40 |
171 |
42% |
|
- Product
- Pathway specific transcriptional regulator
- Gene
-
- Organism
- uncultured soil bacterium
|
1uniprot[Pubmed] 20577994 Cloning large natural product gene clusters from the environment: piecing environmental DNA gene clusters back together with TAR.(Biopolymers) [2010] |
|
94
|
Q9ZA48_STRVN (Q9ZA48) |
|
|
3e-40 |
170 |
39% |
|
- Product
- Pathway-specific transcriptional activator
- Gene
- gra-orf9
- Organism
- Streptomyces violaceoruber
|
1uniprot[Pubmed] 2583128 [Medline] 90060034 Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber Tu22.(EMBO J.) [1989] | 2uniprot[Pubmed] 7476861 [Medline] 96027933 Identification of Streptomyces violaceoruber Tu22 genes involved in the biosynthesis of granaticin.(Mol. Gen. Genet.) [1995] | 3uniprot[Pubmed] 9831526 [Medline] 99051446 The granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tu22: sequence analysis and expression in a heterologous host.(Chem. Biol.) [1998] | [pubmed all]
|
97
|
C7QAG9_CATAD (C7QAG9) |
|
|
9e-40 |
168 |
40% |
|
- Product
- Transcriptional regulator, SARP family
- Gene
- Caci_3563
- Organism
- Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
|
1uniprot Complete genome sequence of Catenulispora acidiphila type strain (ID 139908).(Stand. Genomic Sci.) [2009] |
|
98
|
F4FBT2_VERMA (F4FBT2) |
|
|
7e-39 |
165 |
40% |
|
- Product
- SARP family transcriptional regulator
- Gene
- VAB18032_18150
- Organism
- Verrucosispora maris (strain AB-18-032)
|
1uniprot[Pubmed] 21551311 Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.(J. Bacteriol.) [2011] |
|