Alanine racemization(NFUNC_0063) |
| 必須 | A | ALR (NRULE_0228) | Alanine racemase | bll4070 |
|---|
n-alkane hydroxylation(NFUNC_0008) |
| 必須 | A | CYP153 (NRULE_0041) | Cytochrome P450 CYP153 | blr1853 blr7242 blr7243 |
|---|
| B | ALKB (NRULE_0024) | Alkane 1-monooxygenase | |
| C | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | blr3677 blr3679 |
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | blr3679 blr3677 |
FDR1 (NRULE_0032) | Oxygenase electron transfer component | blr3678 blr2392 blr2895 bll3766 bll4816 blr7998 |
MME (NRULE_0033) | Multicomponent monooxygenase effector protein | blr3680 |
| 任意 | | RUBA (NRULE_0039) | Rubredoxin | bsl6935 |
|---|
| | RUBB (NRULE_0040) | Rubredoxin reductase | |
| | MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
| | MMG2 (NRULE_0030) | Multicomponent monooxygenase gamma subunit | |
| | MMG3 (NRULE_0031) | Multicomponent monooxygenase gamma subunit | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | blr3358 blr2983 blr2485 blr2390 blr1753 bll1070 blr0938 bll7609 blr7649 bll6221 bll7906 bll5204 blr4922 bll6426 blr3400 |
Aminoglycoside resistance (by aminoglycoside O-phosphotransferase)(NFUNC_0043) |
| 必須 | A | APH6 (NRULE_0155) | Streptomycin 6-kinase | |
|---|
| B | APH3 (NRULE_0156) | Aminoglycoside 3'-phosphotransferase | |
| C | APH7 (NRULE_0157) | Hygromycin-B 7''-O-kinase | blr1035 |
| D | HPH (NRULE_0174) | Hygromycin-B 4-O-kinase | |
Ampicillin resistance(NFUNC_0046) |
| 必須 | A | BLAA (NRULE_0122) | Beta-lactamase class A | bll0941 |
|---|
| 任意 | | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
|---|
| | BLAD (NRULE_0125) | Beta-lactamase class D | bll5360 |
Aniline degradation (conversion into catechol)(NFUNC_0075) |
| 必須 | A | ATDA1 (NRULE_0240) | Gamma-glutamylanilide synthetase | |
|---|
ATDA3 (NRULE_0357) | Aniline dioxygenase large subunit | |
ATDA4 (NRULE_0358) | Aniline dioxygenase small subunit | |
| 任意 | | ATDA2 (NRULE_0241) | Putative gamma-glutamylanilide hydrolase | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | blr2895 blr2392 blr7998 bll4816 bll3766 blr3678 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | bll1070 blr0938 bll7906 blr7649 bll7609 bll6426 bll6221 bll5204 blr4922 blr3400 blr3358 blr2983 blr2485 blr2390 blr1753 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | |
Anthranilate biosynthesis(NFUNC_0038) |
| 必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | bll2091 blr2489 |
|---|
TRPE (NRULE_0143) | Anthranilate synthase component I | blr2489 |
Anthranilate degradation (via hydroxylation)(NFUNC_0018) |
| 必須 | A | ANTA (NRULE_0044) | Anthranilate 1,2-dioxygenase large subunit | |
|---|
ANTB (NRULE_0045) | Anthranilate 1,2-dioxygenase small subunit | |
| 任意 | | ANTC (NRULE_0081) | Anthranilate 1,2-dioxygenase electron transfer component | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | blr2392 blr2895 blr7998 bll4816 bll3766 blr3678 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | blr2983 blr0938 bll1070 blr1753 blr2390 blr2485 blr3358 blr3400 blr4922 bll5204 bll6221 bll6426 bll7609 blr7649 bll7906 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | |
Arginine degradation(NFUNC_0074) |
| 必須 | A | ARGI (NRULE_0239) | Arginase | bll6122 |
|---|
Aromatic azo compounds degradation(NFUNC_0073) |
| 必須 | A | AZOR (NRULE_0236) | FMN-dependent NADH-azoreductase | blr5106 bll3368 |
|---|
| B | AZR (NRULE_0237) | NADPH azoreductase | |
| C | AZOB (NRULE_0238) | NAD(P)H azoreductase | |
Aromatic hydrocarbon degradation (via hydroxylation by dioxygenase)(NFUNC_0016) |
| 必須 | A | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | blr4922 blr3400 |
|---|
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | blr3401 |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
| 任意 | | FDR1 (NRULE_0032) | Oxygenase electron transfer component | blr3678 bll3766 blr2392 blr7998 blr2895 bll4816 |
|---|
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | bll1070 blr0938 bll6221 blr1753 blr2390 blr2485 blr2983 blr3358 blr3400 blr4922 bll7906 blr7649 bll7609 bll6426 bll5204 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | |
Arsenical resistance(NFUNC_0004) |
| 必須 | A | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | |
|---|
ARSC1 (NRULE_0017) | Arsenate reductase | bll3084 |
| B | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | |
ARSC2 (NRULE_0018) | Arsenate reductase | bll3086 |
| C | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | |
ARSC3 (NRULE_0019) | Arsenate reductase | |
| D | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | bll3085 |
ARSC1 (NRULE_0017) | Arsenate reductase | bll3084 |
| E | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | bll3085 |
ARSC2 (NRULE_0018) | Arsenate reductase | bll3086 |
| F | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | bll3085 |
ARSC3 (NRULE_0019) | Arsenate reductase | |
| 任意 | | ARSA (NRULE_0014) | Arsenical pump-driving ATPase | |
|---|
| | ARSD (NRULE_0020) | Arsenical resistance operon trans-acting repressor ArsD | |
| | ARSH (NRULE_0021) | ArsH protein | |
Artificial lacto-N-biose biosynthesis(NFUNC_0026) |
| 必須 | A | SP (NRULE_0109) | Sucrose phosphorylase | |
|---|
GALT (NRULE_0110) | Galactose-1-phosphate uridylyltransferase | |
GALE (NRULE_0111) | UDP-glucose 4-epimerase | blr6312 blr7578 blr5931 |
LNBP (NRULE_0112) | 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase | |
Bacitracin resistance(NFUNC_0022) |
| 必須 | A | UPPP (NRULE_0097) | Undecaprenyl-diphosphatase | blr0716 |
|---|
Benzoate degradation (via hydroxylation by dioxygenase)(NFUNC_0017) |
| 必須 | A | BENA (NRULE_0046) | Benzoate 1,2-dioxygenase alpha subunit | |
|---|
BENB (NRULE_0047) | Benzoate 1,2-dioxygenase beta subunit | |
BEND (NRULE_0082) | 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase | |
| 任意 | | BENC (NRULE_0055) | Benzoate 1,2-dioxygenase electron transfer component | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | blr3678 bll3766 blr7998 bll4816 blr2392 blr2895 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | bll6221 bll7609 blr7649 bll7906 blr0938 bll1070 blr1753 blr2390 blr2485 blr2983 blr3358 blr3400 blr4922 bll5204 bll6426 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | |
Beta-lactam antibiotic resistance(NFUNC_0033) |
| 必須 | A | BLAA (NRULE_0122) | Beta-lactamase class A | bll0941 |
|---|
| B | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
| C | BLAC (NRULE_0124) | Beta-lactamase class C | |
| D | BLAD (NRULE_0125) | Beta-lactamase class D | bll5360 |
Bioplastic degradation(NFUNC_0015) |
| 必須 | A | PHAZ1 (NRULE_0023) | Intracellular poly(3-hydroxyalkanoate) depolymerase | blr0908 blr6703 |
|---|
| B | PHAZ2 (NRULE_0080) | Poly(3-hydroxyalkanoate) depolymerase | blr0899 bll4997 |
| C | PHAZ3 (NRULE_0088) | Poly(3-hydroxyalkanoate) depolymerase | |
| 任意 | | PHAY (NRULE_0022) | D-(-)-3-hydroxybutyrate oligomer hydrolase | |
|---|
Bioplastic synthesis(NFUNC_0001) |
| 必須 | A | PHAC1 (NRULE_0010) | Poly(3-hydroxyalkanoate) polymerase | bll4360 blr3732 |
|---|
| B | PHAE (NRULE_0012) | Poly(3-hydroxyalkanoate) polymerase PhaE subunit | |
PHAC2 (NRULE_0373) | Poly(3-hydroxyalkanoate) polymerase PhaC subunit | |
| C | PHAR (NRULE_0013) | Poly(3-hydroxyalkanoate) polymerase PhaR subunit | |
PHAC2 (NRULE_0373) | Poly(3-hydroxyalkanoate) polymerase PhaC subunit | |
| 任意 | | PHAB (NRULE_0011) | Acetoacetyl-CoA reductase | blr3725 bll0225 |
|---|
| | PHAP1 (NRULE_0374) | Phasin | blr2887 bll5155 bll5555 bll6129 bll7395 blr3464 |
| | PHAP2 (NRULE_0375) | Phasin | |
| | PHAP3 (NRULE_0376) | Phasin | |
| | PHAF (NRULE_0377) | Phasin PhaF | |
| | PHAI (NRULE_0378) | Phasin PhaI | |
Biotin biosynthesis(NFUNC_0051) |
| 必須 | A | BIOF (NRULE_0182) | 8-amino-7-oxononanoate synthase | |
|---|
BIOA (NRULE_0183) | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | blr2099 |
BIOD (NRULE_0184) | ATP-dependent dethiobiotin synthetase BioD | blr2098 |
BIOB (NRULE_0185) | Biotin synthase | blr2095 |
Catechol degradation (beta-ketoadipate pathway)(NFUNC_0013) |
| 必須 | A | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | |
|---|
CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | |
CATC (NRULE_0054) | Muconolactone isomerase | |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | blr5668 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | blr0925 |
| B | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | |
CATC (NRULE_0054) | Muconolactone isomerase | |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | blr5668 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | blr0925 |
CATB1 (NRULE_0386) | Muconate cycloisomerase | |
| C | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | |
CATC (NRULE_0054) | Muconolactone isomerase | |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | blr0925 |
CATB1 (NRULE_0386) | Muconate cycloisomerase | |
| D | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | |
CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | |
CATC (NRULE_0054) | Muconolactone isomerase | |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | blr0925 |
Cephalosporin resistance(NFUNC_0048) |
| 必須 | A | BLAC (NRULE_0124) | Beta-lactamase class C | |
|---|
| 任意 | | BLAA (NRULE_0122) | Beta-lactamase class A | bll0941 |
|---|
| | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
Chlorocatechol degradation (beta-ketoadipate pathway)(NFUNC_0104) |
| 必須 | A | PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
|---|
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | blr0925 |
CLCA (NRULE_0382) | Chlorocatechol 1,2-dioxygenase | |
CLCD (NRULE_0383) | Dienelactone hydrolase | bll6841 bll0546 bll0837 bll1234 blr2487 bll3470 bll4335 bll6275 blr5359 bll7509 blr7443 blr6960 |
CLCE (NRULE_0384) | Maleylacetate reductase | bll2682 |
CLCB (NRULE_0387) | Chloromuconate cycloisomerase | |
| B | CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | blr0925 |
CLCA (NRULE_0382) | Chlorocatechol 1,2-dioxygenase | |
CLCD (NRULE_0383) | Dienelactone hydrolase | bll6275 bll7509 blr7443 bll4335 blr6960 blr5359 bll6841 bll0546 bll0837 bll1234 blr2487 bll3470 |
CLCE (NRULE_0384) | Maleylacetate reductase | bll2682 |
| 任意 | | CLCF (NRULE_0385) | Chloromuconolactone dehalogenase | |
|---|
Dibenzothiophene degradation (via desulfurization)(NFUNC_0029) |
| 必須 | A | DSZA (NRULE_0103) | Dibenzothiophene-5,5-dioxide monooxygenase | blr7582 |
|---|
DSZB (NRULE_0104) | 2'-hydroxybiphenyl-2-sulfinate desulfinase | |
DSZC (NRULE_0105) | Dibenzothiophene monooxygenase | |
| 任意 | | FADR1 (NRULE_0101) | NADH-dependent flavin reductase | blr7290 blr1238 blr2425 blr3324 blr3331 blr3398 bll3439 bll6095 bll7007 |
|---|
1,3-dichloropropene degradation(NFUNC_0012) |
| 必須 | A | DHAA (NRULE_0050) | Haloalkane dehalogenase | blr1087 |
|---|
CAAD (NRULE_0076) | 3-chloroacrylic acid dehalogenase | |
MSAD (NRULE_0079) | Malonate semialdehyde decarboxylase | |
| B | DHAA (NRULE_0050) | Haloalkane dehalogenase | blr1087 |
CAADA (NRULE_0077) | 3-chloroacrylic acid dehalogenase alpha subunit | |
CAADB (NRULE_0078) | 3-chloroacrylic acid dehalogenase beta subunit | |
MSAD (NRULE_0079) | Malonate semialdehyde decarboxylase | |
Dihydroxy aromatic compounds degradation (via meta-cleavage pathway)(NFUNC_0011) |
| 必須 | A | EDIO (NRULE_0058) | extradiol dioxygenase | bll2967 bll6462 bll5282 |
|---|
METAH (NRULE_0059) | meta-cleavage compound hydrolase | |
HPDH (NRULE_0063) | 2-hydroxypent-2,4-dienoate hydratase | |
HOA (NRULE_0064) | 4-hydroxy-2-oxovalerate aldolase | |
ACDH (NRULE_0065) | Acetaldehyde dehydrogenase | |
| B | EDIO (NRULE_0058) | extradiol dioxygenase | bll2967 bll5282 bll6462 |
2HMSD (NRULE_0060) | 2-hydroxymuconic semialdehyde dehydrogenase | |
4OT (NRULE_0061) | 4-oxalocrotonate tautomerase | |
4OD (NRULE_0062) | 4-oxalocrotonate decarboxylase | |
HPDH (NRULE_0063) | 2-hydroxypent-2,4-dienoate hydratase | |
HOA (NRULE_0064) | 4-hydroxy-2-oxovalerate aldolase | |
ACDH (NRULE_0065) | Acetaldehyde dehydrogenase | |
Ectoine biosynthesis(NFUNC_0056) |
| 必須 | A | ECTB (NRULE_0186) | Diaminobutyrate--2-oxoglutarate transaminase | |
|---|
ECTA (NRULE_0187) | L-2,4-diaminobutyric acid acetyltransferase | |
ECTC (NRULE_0188) | L-ectoine synthase | blr2106 |
Extracellular electron transfer system(NFUNC_0098) |
| 必須 | A | NAPC (NRULE_0333) | Multiheme c-type cytochrome | blr7040 |
|---|
MTRC (NRULE_0334) | OmcA/MtrC family decaheme c-type cytochrome | |
MTRA (NRULE_0335) | MtrA/DmsE family decaheme c-type cytochrome | |
MTRB (NRULE_0336) | Outer membrane protein MtrB homolog | |
Folate biosynthesis(NFUNC_0044) |
| 必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | blr2489 bll2091 |
|---|
DHPS (NRULE_0144) | Dihydropteroate synthase | bll3059 |
FOLM (NRULE_0146) | Dihydrofolate reductase FolM | |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | bll3058 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | bll3057 |
FOLC (NRULE_0160) | Bifunctional protein FolC | blr0748 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | bll2092 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | |
| B | GLAT (NRULE_0142) | Glutamine amidotransferase | blr2489 bll2091 |
DHPS (NRULE_0144) | Dihydropteroate synthase | bll3059 |
FOLA (NRULE_0147) | Dihydrofolate reductase | bll6510 |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | bll3058 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | bll3057 |
FOLC (NRULE_0160) | Bifunctional protein FolC | blr0748 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | bll2092 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | |
| C | GLAT (NRULE_0142) | Glutamine amidotransferase | bll2091 blr2489 |
DHPS (NRULE_0144) | Dihydropteroate synthase | bll3059 |
DFR2 (NRULE_0148) | Dihydrofolate reductase type 2 | |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | bll3058 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | bll3057 |
FOLC (NRULE_0160) | Bifunctional protein FolC | blr0748 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | bll2092 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | |
Haloalkane degradation (conversion into hydroxyacid)(NFUNC_0010) |
| 必須 | A | DHAA (NRULE_0050) | Haloalkane dehalogenase | blr1087 |
|---|
HAD (NRULE_0051) | (S)-2-haloacid dehalogenase | blr4364 blr7560 |
| B | DHAA (NRULE_0050) | Haloalkane dehalogenase | blr1087 |
DEH (NRULE_0075) | Haloacetate dehalogenase | bll7497 |
Human milk oligosaccharides metabolism(NFUNC_0083) |
| 必須 | A | LNBP (NRULE_0112) | 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase | |
|---|
| 任意 | | NAHK (NRULE_0256) | N-acetylhexosamine 1-kinase | |
|---|
| | GALT (NRULE_0110) | Galactose-1-phosphate uridylyltransferase | |
| | GALE (NRULE_0111) | UDP-glucose 4-epimerase | blr5931 blr6312 blr7578 |
Hydroxyectoine biosynthesis(NFUNC_0057) |
| 必須 | A | ECTD (NRULE_0189) | Ectoine hydroxylase | |
|---|
| 任意 | | ECTB (NRULE_0186) | Diaminobutyrate--2-oxoglutarate transaminase | |
|---|
| | ECTA (NRULE_0187) | L-2,4-diaminobutyric acid acetyltransferase | |
| | ECTC (NRULE_0188) | L-ectoine synthase | blr2106 |
4-hydroxyphenylacetate degradation(NFUNC_0068) |
| 必須 | A | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
|---|
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | bll2968 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | bll2969 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | bll2970 blr1240 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| B | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | bll2967 |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | bll2968 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | bll2969 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | bll2970 blr1240 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| C | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | blr3398 blr7290 bll7007 bll6095 bll3439 blr1238 blr2425 blr3324 blr3331 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | bll2968 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | bll2969 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | blr1240 bll2970 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| D | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | blr3398 blr7290 bll3439 blr3324 blr3331 blr1238 blr2425 bll6095 bll7007 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | bll2967 |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | bll2968 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | bll2969 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | blr1240 bll2970 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| E | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | blr7290 bll6095 blr3324 blr3331 blr3398 bll3439 bll7007 blr1238 blr2425 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | bll2967 |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | bll2968 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | bll2969 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | bll2970 blr1240 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| F | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | bll7007 bll6095 bll3439 blr3398 blr3331 blr2425 blr3324 blr7290 blr1238 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | bll2968 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | bll2969 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | blr1240 bll2970 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| G | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | bll2967 |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | bll2968 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | bll2969 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | blr1240 bll2970 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| H | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | bll2968 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | bll2969 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | blr1240 bll2970 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
Hygromycin resistance(NFUNC_0055) |
| 必須 | A | APH7 (NRULE_0157) | Hygromycin-B 7''-O-kinase | blr1035 |
|---|
| B | HPH (NRULE_0174) | Hygromycin-B 4-O-kinase | |
Macrolide antibiotic resistance(NFUNC_0045) |
| 必須 | A | ERM (NRULE_0164) | rRNA adenine N-6-methyltransferase | |
|---|
| B | RLMA (NRULE_0165) | 23S rRNA (guanine-N(1))-methyltransferase | |
| C | MACA (NRULE_0166) | Macrolide-specific efflux protein MacA | |
MACB (NRULE_0167) | Macrolide export ATP-binding/permease protein MacB | bll3707 |
| D | ERE (NRULE_0168) | Erythromycin esterase | bll4651 |
| E | MPH (NRULE_0169) | Macrolide 2'-phosphotransferase | |
| F | MGT (NRULE_0170) | Macrolide glycosyltransferase | |
Metal-binding protein(NFUNC_0105) |
| 必須 | A | MOP (NRULE_0322) | Putative molybdenum-binding protein | blr6953 blr3917 bll1780 blr1895 blr2437 blr3224 bll6352 blr6644 |
|---|
| B | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | |
| C | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | blr4797 blr6951 blr7099 blr8160 |
| D | MNTR (NRULE_0327) | DtxR family transcriptional regulator MntR | |
| E | CUER (NRULE_0328) | Copper-responsive transcriptional regulator CueR | |
| F | SOXR (NRULE_0329) | Redox-sensitive transcriptional activator SoxR | |
| G | ZNTR (NRULE_0330) | Zinc-responsive transcriptional regulator ZntR | |
| H | NIKR (NRULE_0331) | Nickel-responsive transcriptional regulator NikR | bll0699 |
| I | ISCR (NRULE_0332) | Rrf2 family transcriptional regulator IscR | |
| J | SMTA (NRULE_0009) | Metallothionein | |
Molybdate transport (ABC transporter)(NFUNC_0097) |
| 必須 | A | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | blr8160 blr4797 blr6951 blr7099 |
|---|
| 任意 | | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | |
|---|
| | MODB (NRULE_0325) | Molybdate ABC transporter permease protein | blr6952 blr8161 |
| | MODC (NRULE_0326) | Molybdate ABC transporter ATP-binding protein | bll1780 blr8162 blr6953 |
Mycosamine biosynthesis(NFUNC_0095) |
| 必須 | A | AMPHDII (NRULE_0342) | GDP-3-keto-6-deoxy-D-mannose C-3 aminotransferase | |
|---|
GMD (NRULE_0343) | GDP-mannose 4,6-dehydratase | bll5465 bll1631 |
| 任意 | | AMPHDI (NRULE_0341) | GDP-mycosamine glycosyltransferase | |
|---|
Naphthalene degradation (via hydroxylation by dioxygenase)(NFUNC_0067) |
| 必須 | A | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | blr3400 blr4922 |
|---|
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | blr3401 |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
EDIO (NRULE_0058) | extradiol dioxygenase | bll5282 bll2967 bll6462 |
NAHD (NRULE_0171) | 2-hydroxychromene-2-carboxylate isomerase | |
NAHE (NRULE_0172) | Trans-O-hydroxybenzylidenepyruvate hydratase-aldolase | |
NAHF (NRULE_0173) | Salicylaldehyde dehydrogenase | |
NAHG (NRULE_0190) | Salicylate hydroxylase | |
| B | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | blr4922 blr3400 |
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | blr3401 |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
EDIO (NRULE_0058) | extradiol dioxygenase | bll2967 bll6462 bll5282 |
NAHD (NRULE_0171) | 2-hydroxychromene-2-carboxylate isomerase | |
NAHE (NRULE_0172) | Trans-O-hydroxybenzylidenepyruvate hydratase-aldolase | |
NAHF (NRULE_0173) | Salicylaldehyde dehydrogenase | |
NAGG (NRULE_0191) | Salicylate 5-hydroxylase alpha subunit | |
NAGH (NRULE_0192) | Salicylate 5-hydroxylase beta subunit | |
| 任意 | | FDR1 (NRULE_0032) | Oxygenase electron transfer component | bll4816 blr7998 blr3678 blr2895 blr2392 bll3766 |
|---|
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | blr2983 blr2485 blr2390 blr1753 bll1070 blr0938 bll5204 bll6426 blr7649 bll7906 blr4922 blr3400 blr3358 bll6221 bll7609 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | |
Nitrile hydratase(NFUNC_0002) |
| 必須 | A | NHAA (NRULE_0001) | Nitrile hydratase subunit alpha | bll4498 |
|---|
NHAB (NRULE_0002) | Nitrile hydratase subunit beta | bll4497 |
| 任意 | | P14K (NRULE_0006) | Nitrile hydratase activator P14K | bll4496 |
|---|
| | COBW (NRULE_0007) | CobW/P47K family protein | bll7303 blr3261 bll7768 |
Nitrogenase(NFUNC_0094) |
| 必須 | A | NIFD (NRULE_0347) | Nitrogenase molybdenum-iron protein alpha chain | blr1743 |
|---|
NIFK (NRULE_0348) | Nitrogenase molybdenum-iron protein beta chain | blr1744 |
VNFH (NRULE_0353) | Nitrogenase reductase | blr1769 |
| B | ANFD (NRULE_0344) | Nitrogenase iron-iron protein alpha chain | |
ANFK (NRULE_0345) | Nitrogenase iron-iron protein beta chain | |
ANFG (NRULE_0346) | Nitrogenase iron-iron protein delta chain | |
VNFH (NRULE_0353) | Nitrogenase reductase | blr1769 |
| C | VNFD (NRULE_0349) | Nitrogenase vanadium-iron protein alpha chain | |
VNFK (NRULE_0351) | Nitrogenase vanadium-iron protein beta chain | |
VNFG (NRULE_0352) | Nitrogenase vanadium-iron protein delta chain | |
VNFH (NRULE_0353) | Nitrogenase reductase | blr1769 |
| D | VNFK (NRULE_0350) | Nitrogenase vanadium-iron protein alpha/delta chain | |
VNFK (NRULE_0351) | Nitrogenase vanadium-iron protein beta chain | |
VNFH (NRULE_0353) | Nitrogenase reductase | blr1769 |
(R)-pantothenate biosynthesis(NFUNC_0030) |
| 必須 | A | PAND (NRULE_0115) | Aspartate 1-decarboxylase | blr2096 |
|---|
PANB (NRULE_0116) | 3-methyl-2-oxobutanoate hydroxymethyltransferase | blr2101 blr4048 |
PANE (NRULE_0117) | 2-dehydropantoate 2-reductase | bll0134 bll6396 bll4604 bll3147 blr0589 blr0117 |
PANC (NRULE_0118) | Pantothenate synthetase | blr2102 blr5162 |
Penicillin resistance(NFUNC_0047) |
| 必須 | A | BLAA (NRULE_0122) | Beta-lactamase class A | bll0941 |
|---|
| B | BLAD (NRULE_0125) | Beta-lactamase class D | bll5360 |
| 任意 | | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
|---|
Phenol degradation(NFUNC_0028) |
| 必須 | A | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | blr3677 blr3679 |
|---|
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | blr3677 blr3679 |
MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
| B | PHEA1 (NRULE_0083) | Aromatic ring hydroxylase | |
| C | PHEA2 (NRULE_0084) | Aromatic ring hydroxylase | blr4222 |
| 任意 | | FDR2 (NRULE_0057) | Ferredoxin reductase | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | bll3766 blr7998 bll4816 blr2895 blr2392 blr3678 |
| | MME (NRULE_0033) | Multicomponent monooxygenase effector protein | blr3680 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | bll1070 bll7906 blr7649 bll7609 bll6426 blr0938 bll6221 bll5204 blr4922 blr3400 blr3358 blr2983 blr2485 blr2390 blr1753 |
| | FADR1 (NRULE_0101) | NADH-dependent flavin reductase | bll6095 bll3439 blr7290 bll7007 blr1238 blr2425 blr3324 blr3331 blr3398 |
Protocatechuate degradation (beta-ketoadipate pathway)(NFUNC_0014) |
| 必須 | A | PCAG (NRULE_0066) | Protocatechuate 3,4-dioxygenase alpha subunit | blr2334 blr0928 |
|---|
PCAH (NRULE_0067) | Protocatechuate 3,4-dioxygenase beta subunit | blr0927 blr2333 |
PCAB (NRULE_0068) | 3-carboxy-cis,cis-muconate cycloisomerase | blr5667 bll7942 |
PCAC (NRULE_0069) | 4-carboxymuconolactone decarboxylase | |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | blr5668 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | blr0925 |
| B | PCAG (NRULE_0066) | Protocatechuate 3,4-dioxygenase alpha subunit | blr0928 blr2334 |
PCAH (NRULE_0067) | Protocatechuate 3,4-dioxygenase beta subunit | blr2333 blr0927 |
PCAB (NRULE_0068) | 3-carboxy-cis,cis-muconate cycloisomerase | blr5667 bll7942 |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | blr0925 |
Pyrroloquinoline quinone biosynthesis(NFUNC_0020) |
| 必須 | A | PQQC (NRULE_0092) | Pyrroloquinoline-quinone synthase | blr6737 |
|---|
| 任意 | | PQQA (NRULE_0090) | Coenzyme PQQ synthesis protein A | bsr6735 |
|---|
| | PQQB (NRULE_0091) | Coenzyme PQQ synthesis protein B | blr6736 |
| | PQQD (NRULE_0093) | Coenzyme PQQ synthesis protein D | blr6738 |
| | PQQE (NRULE_0094) | Coenzyme PQQ synthesis protein E | blr6739 |
| | PQQF (NRULE_0095) | Coenzyme PQQ synthesis protein F | |
Riboflavin biosynthesis(NFUNC_0058) |
| 必須 | A | RIBB (NRULE_0200) | 3,4-dihydroxy-2-butanone 4-phosphate synthase | blr2615 |
|---|
RIBA (NRULE_0201) | GTP cyclohydrolase-2 | blr7237 blr2615 |
RIBD (NRULE_0202) | Riboflavin biosynthesis protein RibD | bll5031 |
RIBH (NRULE_0203) | 6,7-dimethyl-8-ribityllumazine synthase | bll5029 bll7452 |
RIBE (NRULE_0204) | Riboflavin synthase | bll5030 |
| 任意 | | RIBF (NRULE_0205) | Riboflavin biosynthesis protein RibF | blr7480 |
|---|
Thiocyanate hydrolase(NFUNC_0003) |
| 必須 | A | SCNA (NRULE_0003) | Thiocyanate hydrolase subunit alpha | bll4496 bll4497 |
|---|
SCNB (NRULE_0004) | Thiocyanate hydrolase subunit beta | bll4496 bll4497 |
SCNC (NRULE_0005) | Thiocyanate hydrolase subunit gamma | |
| B | SCNA (NRULE_0003) | Thiocyanate hydrolase subunit alpha | bll4497 bll4496 |
SCNC (NRULE_0005) | Thiocyanate hydrolase subunit gamma | |
| C | SCNB (NRULE_0004) | Thiocyanate hydrolase subunit beta | bll4496 bll4497 |
SCNC (NRULE_0005) | Thiocyanate hydrolase subunit gamma | |
Toluene degradation (conversion into protocatechuate via p-cresol)(NFUNC_0007) |
| 必須 | A | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | blr3679 blr3677 |
|---|
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | blr3679 blr3677 |
FDR1 (NRULE_0032) | Oxygenase electron transfer component | blr2392 bll4816 blr3678 bll3766 blr7998 blr2895 |
MME (NRULE_0033) | Multicomponent monooxygenase effector protein | blr3680 |
PCHF (NRULE_0035) | 4-cresol dehydrogenase flavoprotein subunit | |
PCHC (NRULE_0036) | 4-cresol dehydrogenase cytochrome c subunit | |
PCHA (NRULE_0037) | p-hydroxybenzaldehyde dehydrogenase | |
POBA (NRULE_0038) | p-hydroxybenzoate hydroxylase | bll7838 blr2337 |
| 任意 | | MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
|---|
| | MMG2 (NRULE_0030) | Multicomponent monooxygenase gamma subunit | |
| | MMG3 (NRULE_0031) | Multicomponent monooxygenase gamma subunit | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | blr2485 bll7906 blr7649 bll7609 bll6426 bll6221 bll5204 blr4922 blr3400 blr3358 blr2983 blr2390 blr1753 bll1070 blr0938 |
Trehalose biosynthesis (from maltooligosaccharide)(NFUNC_0037) |
| 必須 | A | TREY (NRULE_0140) | Maltooligosyl trehalose synthase | blr6771 |
|---|
TREZ (NRULE_0141) | Malto-oligosyltrehalose trehalohydrolase | blr6770 |
| 任意 | | GLGX (NRULE_0139) | Glycogen debranching enzyme | blr6769 |
|---|
Trehalose biosynthesis (from maltose)(NFUNC_0034) |
| 必須 | A | MAPA (NRULE_0126) | Maltose phosphorylase | |
|---|
TREP (NRULE_0127) | Alpha,alpha-trehalose phosphorylase | |
| B | TRES (NRULE_0128) | Trehalose synthase | blr6767 |
Trehalose biosynthesis (from NDP-glucose and glucose-6-phosphate)(NFUNC_0031) |
| 必須 | A | TPS (NRULE_0119) | Trehalose-phosphate synthase | |
|---|
TPP (NRULE_0120) | Trehalose-6-phosphate phosphatase | bll0323 |
Vitamin B6 biosynthesis (PdxA/PdxJ pathway)(NFUNC_0060) |
| 必須 | A | EPD (NRULE_0208) | D-erythrose-4-phosphate dehydrogenase | |
|---|
PDXB (NRULE_0209) | Erythronate-4-phosphate dehydrogenase | |
SERC (NRULE_0210) | Phosphoserine aminotransferase | |
PDXA (NRULE_0211) | 4-hydroxythreonine-4-phosphate dehydrogenase | blr3887 bll4103 blr4374 |
PDXJ (NRULE_0212) | Pyridoxine 5'-phosphate synthase | bll5064 |
