Acid resistance (by GABA antiporter)(NFUNC_0071) |
| Require | A | GAD (NRULE_0231) | Glutamate decarboxylase | HMPREF0693_0980 |
|---|
GADC (NRULE_0234) | Glutamate/gamma-aminobutyrate antiporter | HMPREF0693_0979 |
Alanine racemization(NFUNC_0063) |
| Require | A | ALR (NRULE_0228) | Alanine racemase | HMPREF0693_2890 HMPREF0693_1417 HMPREF0693_1085 |
|---|
n-alkane hydroxylation(NFUNC_0008) |
| Require | A | CYP153 (NRULE_0041) | Cytochrome P450 CYP153 | |
|---|
| B | ALKB (NRULE_0024) | Alkane 1-monooxygenase | |
| C | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | |
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | |
FDR1 (NRULE_0032) | Oxygenase electron transfer component | HMPREF0693_3078 HMPREF0693_1745 |
MME (NRULE_0033) | Multicomponent monooxygenase effector protein | |
| Participant | | RUBA (NRULE_0039) | Rubredoxin | |
|---|
| | RUBB (NRULE_0040) | Rubredoxin reductase | |
| | MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
| | MMG2 (NRULE_0030) | Multicomponent monooxygenase gamma subunit | |
| | MMG3 (NRULE_0031) | Multicomponent monooxygenase gamma subunit | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | |
Aminoglycoside resistance (by aminoglycoside O-nucleotidyltransferase)(NFUNC_0042) |
| Require | A | ANT6 (NRULE_0151) | Aminoglycoside 6-adenylyltransferase | HMPREF0693_1939 |
|---|
| B | ANT4 (NRULE_0152) | Kanamycin nucleotidyltransferase | |
| C | ANT2 (NRULE_0153) | 2''-aminoglycoside nucleotidyltransferase | |
| D | ANT3 (NRULE_0154) | Streptomycin 3''-adenylyltransferase | |
Aniline degradation (conversion into catechol)(NFUNC_0075) |
| Require | A | ATDA1 (NRULE_0240) | Gamma-glutamylanilide synthetase | |
|---|
ATDA3 (NRULE_0357) | Aniline dioxygenase large subunit | |
ATDA4 (NRULE_0358) | Aniline dioxygenase small subunit | |
| Participant | | ATDA2 (NRULE_0241) | Putative gamma-glutamylanilide hydrolase | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | HMPREF0693_1745 HMPREF0693_3078 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | |
Anthranilate biosynthesis(NFUNC_0038) |
| Require | A | GLAT (NRULE_0142) | Glutamine amidotransferase | HMPREF0693_0913 HMPREF0693_0460 |
|---|
TRPE (NRULE_0143) | Anthranilate synthase component I | HMPREF0693_0912 |
Anthranilate degradation (via hydroxylation)(NFUNC_0018) |
| Require | A | ANTA (NRULE_0044) | Anthranilate 1,2-dioxygenase large subunit | |
|---|
ANTB (NRULE_0045) | Anthranilate 1,2-dioxygenase small subunit | |
| Participant | | ANTC (NRULE_0081) | Anthranilate 1,2-dioxygenase electron transfer component | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | HMPREF0693_1745 HMPREF0693_3078 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | |
Aromatic azo compounds degradation(NFUNC_0073) |
| Require | A | AZOR (NRULE_0236) | FMN-dependent NADH-azoreductase | HMPREF0693_0741 |
|---|
| B | AZR (NRULE_0237) | NADPH azoreductase | |
| C | AZOB (NRULE_0238) | NAD(P)H azoreductase | |
Aromatic hydrocarbon degradation (via hydroxylation by dioxygenase)(NFUNC_0016) |
| Require | A | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | |
|---|
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
| Participant | | FDR1 (NRULE_0032) | Oxygenase electron transfer component | HMPREF0693_1745 HMPREF0693_3078 |
|---|
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | |
Arsenical resistance(NFUNC_0004) |
| Require | A | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | HMPREF0693_1786 |
|---|
ARSC1 (NRULE_0017) | Arsenate reductase | HMPREF0693_1195 |
| B | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | HMPREF0693_1786 |
ARSC2 (NRULE_0018) | Arsenate reductase | |
| C | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | HMPREF0693_1786 |
ARSC3 (NRULE_0019) | Arsenate reductase | |
| D | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | |
ARSC1 (NRULE_0017) | Arsenate reductase | HMPREF0693_1195 |
| E | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | |
ARSC2 (NRULE_0018) | Arsenate reductase | |
| F | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | |
ARSC3 (NRULE_0019) | Arsenate reductase | |
| Participant | | ARSA (NRULE_0014) | Arsenical pump-driving ATPase | |
|---|
| | ARSD (NRULE_0020) | Arsenical resistance operon trans-acting repressor ArsD | |
| | ARSH (NRULE_0021) | ArsH protein | |
Artificial lacto-N-biose biosynthesis(NFUNC_0026) |
| Require | A | SP (NRULE_0109) | Sucrose phosphorylase | |
|---|
GALT (NRULE_0110) | Galactose-1-phosphate uridylyltransferase | HMPREF0693_1609 |
GALE (NRULE_0111) | UDP-glucose 4-epimerase | HMPREF0693_1610 |
LNBP (NRULE_0112) | 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase | |
Benzoate degradation (via hydroxylation by dioxygenase)(NFUNC_0017) |
| Require | A | BENA (NRULE_0046) | Benzoate 1,2-dioxygenase alpha subunit | |
|---|
BENB (NRULE_0047) | Benzoate 1,2-dioxygenase beta subunit | |
BEND (NRULE_0082) | 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase | |
| Participant | | BENC (NRULE_0055) | Benzoate 1,2-dioxygenase electron transfer component | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | HMPREF0693_3078 HMPREF0693_1745 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | |
Betaine biosynthesis (from choline)(NFUNC_0049) |
| Require | A | BETA (NRULE_0175) | Choline dehydrogenase | HMPREF0693_1034 |
|---|
| B | GBSB (NRULE_0176) | Alcohol dehydrogenase | |
BETB (NRULE_0177) | Betaine aldehyde dehydrogenase | HMPREF0693_1035 |
| C | CHOX (NRULE_0178) | Choline oxidase | |
Biotin biosynthesis(NFUNC_0051) |
| Require | A | BIOF (NRULE_0182) | 8-amino-7-oxononanoate synthase | HMPREF0693_1957 |
|---|
BIOA (NRULE_0183) | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | HMPREF0693_1955 |
BIOD (NRULE_0184) | ATP-dependent dethiobiotin synthetase BioD | HMPREF0693_0865 HMPREF0693_1959 |
BIOB (NRULE_0185) | Biotin synthase | HMPREF0693_1956 |
Chloramphenicol resistance(NFUNC_0025) |
| Require | A | CAT1 (NRULE_0107) | Chloramphenicol acetyltransferase | HMPREF0693_2081 |
|---|
| B | CAT4 (NRULE_0108) | Chloramphenicol acetyltransferase | |
Dibenzothiophene degradation (via desulfurization)(NFUNC_0029) |
| Require | A | DSZA (NRULE_0103) | Dibenzothiophene-5,5-dioxide monooxygenase | |
|---|
DSZB (NRULE_0104) | 2'-hydroxybiphenyl-2-sulfinate desulfinase | |
DSZC (NRULE_0105) | Dibenzothiophene monooxygenase | |
| Participant | | FADR1 (NRULE_0101) | NADH-dependent flavin reductase | HMPREF0693_3207 |
|---|
Dihydroxy aromatic compounds degradation (via meta-cleavage pathway)(NFUNC_0011) |
| Require | A | EDIO (NRULE_0058) | extradiol dioxygenase | HMPREF0693_2565 |
|---|
METAH (NRULE_0059) | meta-cleavage compound hydrolase | |
HPDH (NRULE_0063) | 2-hydroxypent-2,4-dienoate hydratase | |
HOA (NRULE_0064) | 4-hydroxy-2-oxovalerate aldolase | |
ACDH (NRULE_0065) | Acetaldehyde dehydrogenase | |
| B | EDIO (NRULE_0058) | extradiol dioxygenase | HMPREF0693_2565 |
2HMSD (NRULE_0060) | 2-hydroxymuconic semialdehyde dehydrogenase | |
4OT (NRULE_0061) | 4-oxalocrotonate tautomerase | HMPREF0693_0442 |
4OD (NRULE_0062) | 4-oxalocrotonate decarboxylase | |
HPDH (NRULE_0063) | 2-hydroxypent-2,4-dienoate hydratase | |
HOA (NRULE_0064) | 4-hydroxy-2-oxovalerate aldolase | |
ACDH (NRULE_0065) | Acetaldehyde dehydrogenase | |
Folate biosynthesis(NFUNC_0044) |
| Require | A | GLAT (NRULE_0142) | Glutamine amidotransferase | HMPREF0693_0913 HMPREF0693_0460 |
|---|
DHPS (NRULE_0144) | Dihydropteroate synthase | HMPREF0693_2341 |
FOLM (NRULE_0146) | Dihydrofolate reductase FolM | |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | HMPREF0693_2573 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | HMPREF0693_3254 |
FOLC (NRULE_0160) | Bifunctional protein FolC | HMPREF0693_1429 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | HMPREF0693_1233 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | HMPREF0693_2994 |
| B | GLAT (NRULE_0142) | Glutamine amidotransferase | HMPREF0693_0460 HMPREF0693_0913 |
DHPS (NRULE_0144) | Dihydropteroate synthase | HMPREF0693_2341 |
FOLA (NRULE_0147) | Dihydrofolate reductase | HMPREF0693_2551 |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | HMPREF0693_2573 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | HMPREF0693_3254 |
FOLC (NRULE_0160) | Bifunctional protein FolC | HMPREF0693_1429 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | HMPREF0693_1233 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | HMPREF0693_2994 |
| C | GLAT (NRULE_0142) | Glutamine amidotransferase | HMPREF0693_0913 HMPREF0693_0460 |
DHPS (NRULE_0144) | Dihydropteroate synthase | HMPREF0693_2341 |
DFR2 (NRULE_0148) | Dihydrofolate reductase type 2 | |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | HMPREF0693_2573 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | HMPREF0693_3254 |
FOLC (NRULE_0160) | Bifunctional protein FolC | HMPREF0693_1429 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | HMPREF0693_1233 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | HMPREF0693_2994 |
GABA biosynthesis(NFUNC_0066) |
| Require | A | GAD (NRULE_0231) | Glutamate decarboxylase | HMPREF0693_0980 |
|---|
Human milk oligosaccharides metabolism(NFUNC_0083) |
| Require | A | LNBP (NRULE_0112) | 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase | |
|---|
| Participant | | NAHK (NRULE_0256) | N-acetylhexosamine 1-kinase | |
|---|
| | GALT (NRULE_0110) | Galactose-1-phosphate uridylyltransferase | HMPREF0693_1609 |
| | GALE (NRULE_0111) | UDP-glucose 4-epimerase | HMPREF0693_1610 |
4-hydroxyphenylacetate degradation(NFUNC_0068) |
| Require | A | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
|---|
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | HMPREF0693_3207 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| B | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | HMPREF0693_3207 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| C | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | HMPREF0693_3207 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| D | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | HMPREF0693_3207 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| E | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | HMPREF0693_3207 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| F | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | HMPREF0693_3207 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| G | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | HMPREF0693_3207 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| H | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | HMPREF0693_3207 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
Macrolide antibiotic resistance(NFUNC_0045) |
| Require | A | ERM (NRULE_0164) | rRNA adenine N-6-methyltransferase | |
|---|
| B | RLMA (NRULE_0165) | 23S rRNA (guanine-N(1))-methyltransferase | HMPREF0693_1237 |
| C | MACA (NRULE_0166) | Macrolide-specific efflux protein MacA | |
MACB (NRULE_0167) | Macrolide export ATP-binding/permease protein MacB | HMPREF0693_2040 |
| D | ERE (NRULE_0168) | Erythromycin esterase | |
| E | MPH (NRULE_0169) | Macrolide 2'-phosphotransferase | |
| F | MGT (NRULE_0170) | Macrolide glycosyltransferase | |
Metal-binding protein(NFUNC_0105) |
| Require | A | MOP (NRULE_0322) | Putative molybdenum-binding protein | HMPREF0693_1948 HMPREF0693_1952 |
|---|
| B | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | HMPREF0693_1948 |
| C | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | HMPREF0693_1116 HMPREF0693_2620 HMPREF0693_1950 HMPREF0693_1480 HMPREF0693_3261 |
| D | MNTR (NRULE_0327) | DtxR family transcriptional regulator MntR | |
| E | CUER (NRULE_0328) | Copper-responsive transcriptional regulator CueR | HMPREF0693_1812 HMPREF0693_1693 |
| F | SOXR (NRULE_0329) | Redox-sensitive transcriptional activator SoxR | HMPREF0693_2852 |
| G | ZNTR (NRULE_0330) | Zinc-responsive transcriptional regulator ZntR | HMPREF0693_0214 |
| H | NIKR (NRULE_0331) | Nickel-responsive transcriptional regulator NikR | |
| I | ISCR (NRULE_0332) | Rrf2 family transcriptional regulator IscR | HMPREF0693_1507 |
| J | SMTA (NRULE_0009) | Metallothionein | |
Molybdate transport (ABC transporter)(NFUNC_0097) |
| Require | A | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | HMPREF0693_1480 HMPREF0693_2620 HMPREF0693_1116 HMPREF0693_1950 HMPREF0693_3261 |
|---|
| Participant | | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | HMPREF0693_1948 |
|---|
| | MODB (NRULE_0325) | Molybdate ABC transporter permease protein | HMPREF0693_1951 |
| | MODC (NRULE_0326) | Molybdate ABC transporter ATP-binding protein | HMPREF0693_1952 |
Naphthalene degradation (via hydroxylation by dioxygenase)(NFUNC_0067) |
| Require | A | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | |
|---|
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
EDIO (NRULE_0058) | extradiol dioxygenase | HMPREF0693_2565 |
NAHD (NRULE_0171) | 2-hydroxychromene-2-carboxylate isomerase | |
NAHE (NRULE_0172) | Trans-O-hydroxybenzylidenepyruvate hydratase-aldolase | |
NAHF (NRULE_0173) | Salicylaldehyde dehydrogenase | |
NAHG (NRULE_0190) | Salicylate hydroxylase | |
| B | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | |
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
EDIO (NRULE_0058) | extradiol dioxygenase | HMPREF0693_2565 |
NAHD (NRULE_0171) | 2-hydroxychromene-2-carboxylate isomerase | |
NAHE (NRULE_0172) | Trans-O-hydroxybenzylidenepyruvate hydratase-aldolase | |
NAHF (NRULE_0173) | Salicylaldehyde dehydrogenase | |
NAGG (NRULE_0191) | Salicylate 5-hydroxylase alpha subunit | |
NAGH (NRULE_0192) | Salicylate 5-hydroxylase beta subunit | |
| Participant | | FDR1 (NRULE_0032) | Oxygenase electron transfer component | HMPREF0693_3078 HMPREF0693_1745 |
|---|
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | |
Nitrile hydratase(NFUNC_0002) |
| Require | A | NHAA (NRULE_0001) | Nitrile hydratase subunit alpha | |
|---|
NHAB (NRULE_0002) | Nitrile hydratase subunit beta | |
| Participant | | P14K (NRULE_0006) | Nitrile hydratase activator P14K | |
|---|
| | COBW (NRULE_0007) | CobW/P47K family protein | HMPREF0693_3305 |
(R)-pantothenate biosynthesis(NFUNC_0030) |
| Require | A | PAND (NRULE_0115) | Aspartate 1-decarboxylase | HMPREF0693_3257 |
|---|
PANB (NRULE_0116) | 3-methyl-2-oxobutanoate hydroxymethyltransferase | HMPREF0693_3255 |
PANE (NRULE_0117) | 2-dehydropantoate 2-reductase | HMPREF0693_3349 |
PANC (NRULE_0118) | Pantothenate synthetase | HMPREF0693_3256 |
Phenol degradation(NFUNC_0028) |
| Require | A | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | |
|---|
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | |
MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
| B | PHEA1 (NRULE_0083) | Aromatic ring hydroxylase | |
| C | PHEA2 (NRULE_0084) | Aromatic ring hydroxylase | |
| Participant | | FDR2 (NRULE_0057) | Ferredoxin reductase | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | HMPREF0693_1745 HMPREF0693_3078 |
| | MME (NRULE_0033) | Multicomponent monooxygenase effector protein | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | |
| | FADR1 (NRULE_0101) | NADH-dependent flavin reductase | HMPREF0693_3207 |
Polymyxin resistance(NFUNC_0036) |
| Require | A | ARNA (NRULE_0132) | Bifunctional polymyxin resistance protein ArnA | HMPREF0693_0618 |
|---|
ARNB (NRULE_0133) | UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase | HMPREF0693_0616 |
ARNC (NRULE_0134) | Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase | HMPREF0693_0617 |
ARND (NRULE_0135) | Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD | HMPREF0693_0619 |
ARNE (NRULE_0136) | Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE | HMPREF0693_0621 |
ARNF (NRULE_0137) | Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF | HMPREF0693_0622 |
ARNT (NRULE_0138) | Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase | HMPREF0693_0620 HMPREF0693_3176 |
Riboflavin biosynthesis(NFUNC_0058) |
| Require | A | RIBB (NRULE_0200) | 3,4-dihydroxy-2-butanone 4-phosphate synthase | HMPREF0693_2566 |
|---|
RIBA (NRULE_0201) | GTP cyclohydrolase-2 | HMPREF0693_0892 |
RIBD (NRULE_0202) | Riboflavin biosynthesis protein RibD | HMPREF0693_3369 |
RIBH (NRULE_0203) | 6,7-dimethyl-8-ribityllumazine synthase | HMPREF0693_3368 |
RIBE (NRULE_0204) | Riboflavin synthase | HMPREF0693_0975 |
| Participant | | RIBF (NRULE_0205) | Riboflavin biosynthesis protein RibF | HMPREF0693_3434 |
|---|
Streptomycin resistance(NFUNC_0054) |
| Require | A | ANT6 (NRULE_0151) | Aminoglycoside 6-adenylyltransferase | HMPREF0693_1939 |
|---|
| B | ANT3 (NRULE_0154) | Streptomycin 3''-adenylyltransferase | |
| C | APH6 (NRULE_0155) | Streptomycin 6-kinase | |
| Participant | | APH3 (NRULE_0156) | Aminoglycoside 3'-phosphotransferase | |
|---|
Toluene degradation (conversion into protocatechuate via p-cresol)(NFUNC_0007) |
| Require | A | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | |
|---|
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | |
FDR1 (NRULE_0032) | Oxygenase electron transfer component | HMPREF0693_3078 HMPREF0693_1745 |
MME (NRULE_0033) | Multicomponent monooxygenase effector protein | |
PCHF (NRULE_0035) | 4-cresol dehydrogenase flavoprotein subunit | |
PCHC (NRULE_0036) | 4-cresol dehydrogenase cytochrome c subunit | |
PCHA (NRULE_0037) | p-hydroxybenzaldehyde dehydrogenase | |
POBA (NRULE_0038) | p-hydroxybenzoate hydroxylase | |
| Participant | | MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
|---|
| | MMG2 (NRULE_0030) | Multicomponent monooxygenase gamma subunit | |
| | MMG3 (NRULE_0031) | Multicomponent monooxygenase gamma subunit | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | |
Uptake of osmoprotectant(NFUNC_0061) |
| Require | A | OPUAC (NRULE_0213) | Osmoprotectant ABC transporter substrate-binding protein | HMPREF0693_3765 |
|---|
OPUAB (NRULE_0214) | Osmoprotectant ABC transporter permease protein | HMPREF0693_3764 |
OPUAA (NRULE_0215) | Osmoprotectant ABC transporter ATP-binding protein | HMPREF0693_3763 |
| B | EHUB (NRULE_0216) | Ectoine ABC transporter substrate-binding protein | |
EHUC (NRULE_0217) | Ectoine ABC transporter permease protein | |
EHUD (NRULE_0218) | Ectoine ABC transporter permease protein | |
EHUA (NRULE_0219) | Ectoine ABC transporter ATP-binding protein | |
| C | BCCT (NRULE_0220) | BCCT family transporter | HMPREF0693_1037 HMPREF0693_2800 HMPREF0693_3204 |
| D | PROP (NRULE_0221) | Osmoprotectant transporter | HMPREF0693_0019 |
| E | OPUE (NRULE_0222) | Sodium/proline symporter | HMPREF0693_1248 |
| F | TEAA (NRULE_0223) | TRAP transporter substrate-binding protein TeaA | |
TEAB (NRULE_0224) | TRAP transporter small transmembrane protein TeaB | |
TEAC (NRULE_0225) | TRAP transporter large transmembrane protein TeaC | |
Vitamin B6 biosynthesis (PdxA/PdxJ pathway)(NFUNC_0060) |
| Require | A | EPD (NRULE_0208) | D-erythrose-4-phosphate dehydrogenase | HMPREF0693_3212 |
|---|
PDXB (NRULE_0209) | Erythronate-4-phosphate dehydrogenase | HMPREF0693_1434 |
SERC (NRULE_0210) | Phosphoserine aminotransferase | HMPREF0693_2064 |
PDXA (NRULE_0211) | 4-hydroxythreonine-4-phosphate dehydrogenase | HMPREF0693_2547 |
PDXJ (NRULE_0212) | Pyridoxine 5'-phosphate synthase | HMPREF0693_1534 |
