Acid resistance (by GABA antiporter)(NFUNC_0071) |
| 必須 | A | GAD (NRULE_0231) | Glutamate decarboxylase | RER_35380 |
|---|
GADC (NRULE_0234) | Glutamate/gamma-aminobutyrate antiporter | |
Alanine racemization(NFUNC_0063) |
| 必須 | A | ALR (NRULE_0228) | Alanine racemase | RER_19140 |
|---|
n-alkane hydroxylation(NFUNC_0008) |
| 必須 | A | CYP153 (NRULE_0041) | Cytochrome P450 CYP153 | RER_pREL1-02600 RER_pREL1-02830 |
|---|
| B | ALKB (NRULE_0024) | Alkane 1-monooxygenase | RER_07460 RER_21620 RER_24030 RER_54580 |
| C | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | |
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | |
FDR1 (NRULE_0032) | Oxygenase electron transfer component | RER_38520 RER_00070 RER_17750 RER_21780 RER_55460 RER_46640 |
MME (NRULE_0033) | Multicomponent monooxygenase effector protein | |
| 任意 | | RUBA (NRULE_0039) | Rubredoxin | RER_21640 RER_21630 RER_07480 RER_07470 |
|---|
| | RUBB (NRULE_0040) | Rubredoxin reductase | RER_07490 |
| | MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
| | MMG2 (NRULE_0030) | Multicomponent monooxygenase gamma subunit | |
| | MMG3 (NRULE_0031) | Multicomponent monooxygenase gamma subunit | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | RER_51130 RER_57010 RER_pREL1-01130 RER_35970 RER_13800 RER_09150 RER_07540 |
Aniline degradation (conversion into catechol)(NFUNC_0075) |
| 必須 | A | ATDA1 (NRULE_0240) | Gamma-glutamylanilide synthetase | |
|---|
ATDA3 (NRULE_0357) | Aniline dioxygenase large subunit | |
ATDA4 (NRULE_0358) | Aniline dioxygenase small subunit | |
| 任意 | | ATDA2 (NRULE_0241) | Putative gamma-glutamylanilide hydrolase | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | RER_38520 RER_00070 RER_17750 RER_21780 RER_46640 RER_55460 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | RER_pREL1-01130 RER_07540 RER_09150 RER_13800 RER_35970 RER_51130 RER_57010 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | RER_pREL1-02840 RER_07950 RER_pREL1-02610 |
Anthranilate biosynthesis(NFUNC_0038) |
| 必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | RER_00270 RER_18480 |
|---|
TRPE (NRULE_0143) | Anthranilate synthase component I | RER_33560 |
Anthranilate degradation (via hydroxylation)(NFUNC_0018) |
| 必須 | A | ANTA (NRULE_0044) | Anthranilate 1,2-dioxygenase large subunit | |
|---|
ANTB (NRULE_0045) | Anthranilate 1,2-dioxygenase small subunit | |
| 任意 | | ANTC (NRULE_0081) | Anthranilate 1,2-dioxygenase electron transfer component | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | RER_00070 RER_17750 RER_21780 RER_38520 RER_46640 RER_55460 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | RER_09150 RER_07540 RER_13800 RER_35970 RER_51130 RER_57010 RER_pREL1-01130 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | RER_pREL1-02840 RER_pREL1-02610 RER_07950 |
Aromatic azo compounds degradation(NFUNC_0073) |
| 必須 | A | AZOR (NRULE_0236) | FMN-dependent NADH-azoreductase | RER_13480 |
|---|
| B | AZR (NRULE_0237) | NADPH azoreductase | |
| C | AZOB (NRULE_0238) | NAD(P)H azoreductase | |
Aromatic hydrocarbon degradation (via hydroxylation by dioxygenase)(NFUNC_0016) |
| 必須 | A | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | |
|---|
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
| 任意 | | FDR1 (NRULE_0032) | Oxygenase electron transfer component | RER_21780 RER_17750 RER_38520 RER_46640 RER_55460 RER_00070 |
|---|
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | RER_07540 RER_57010 RER_51130 RER_35970 RER_13800 RER_09150 RER_pREL1-01130 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | RER_07950 RER_pREL1-02610 RER_pREL1-02840 |
Arsenical resistance(NFUNC_0004) |
| 必須 | A | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | |
|---|
ARSC1 (NRULE_0017) | Arsenate reductase | RER_43750 |
| B | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | |
ARSC2 (NRULE_0018) | Arsenate reductase | |
| C | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | |
ARSC3 (NRULE_0019) | Arsenate reductase | |
| D | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | RER_35200 RER_pREL1-01590 |
ARSC1 (NRULE_0017) | Arsenate reductase | RER_43750 |
| E | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | RER_35200 RER_pREL1-01590 |
ARSC2 (NRULE_0018) | Arsenate reductase | |
| F | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | RER_35200 RER_pREL1-01590 |
ARSC3 (NRULE_0019) | Arsenate reductase | |
| 任意 | | ARSA (NRULE_0014) | Arsenical pump-driving ATPase | RER_pREL1-01650 |
|---|
| | ARSD (NRULE_0020) | Arsenical resistance operon trans-acting repressor ArsD | RER_pREL1-01640 |
| | ARSH (NRULE_0021) | ArsH protein | |
Artificial lacto-N-biose biosynthesis(NFUNC_0026) |
| 必須 | A | SP (NRULE_0109) | Sucrose phosphorylase | |
|---|
GALT (NRULE_0110) | Galactose-1-phosphate uridylyltransferase | RER_55400 |
GALE (NRULE_0111) | UDP-glucose 4-epimerase | RER_28000 RER_31180 |
LNBP (NRULE_0112) | 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase | |
Bacitracin resistance(NFUNC_0022) |
| 必須 | A | UPPP (NRULE_0097) | Undecaprenyl-diphosphatase | RER_32020 |
|---|
Benzoate degradation (via hydroxylation by dioxygenase)(NFUNC_0017) |
| 必須 | A | BENA (NRULE_0046) | Benzoate 1,2-dioxygenase alpha subunit | |
|---|
BENB (NRULE_0047) | Benzoate 1,2-dioxygenase beta subunit | |
BEND (NRULE_0082) | 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase | |
| 任意 | | BENC (NRULE_0055) | Benzoate 1,2-dioxygenase electron transfer component | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | RER_17750 RER_55460 RER_38520 RER_46640 RER_21780 RER_00070 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | RER_07540 RER_35970 RER_13800 RER_09150 RER_pREL1-01130 RER_57010 RER_51130 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | RER_pREL1-02610 RER_07950 RER_pREL1-02840 |
Biotin biosynthesis(NFUNC_0051) |
| 必須 | A | BIOF (NRULE_0182) | 8-amino-7-oxononanoate synthase | |
|---|
BIOA (NRULE_0183) | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | RER_35050 |
BIOD (NRULE_0184) | ATP-dependent dethiobiotin synthetase BioD | RER_35030 |
BIOB (NRULE_0185) | Biotin synthase | RER_34880 |
Catechol degradation (beta-ketoadipate pathway)(NFUNC_0013) |
| 必須 | A | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | RER_54230 |
|---|
CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | RER_54220 |
CATC (NRULE_0054) | Muconolactone isomerase | RER_54210 |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | RER_52890 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | RER_52850 RER_12090 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | RER_52840 RER_18360 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | RER_52080 RER_52910 |
| B | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | RER_54230 |
CATC (NRULE_0054) | Muconolactone isomerase | RER_54210 |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | RER_52890 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | RER_52850 RER_12090 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | RER_18360 RER_52840 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | RER_52080 RER_52910 |
CATB1 (NRULE_0386) | Muconate cycloisomerase | RER_54220 |
| C | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | RER_54230 |
CATC (NRULE_0054) | Muconolactone isomerase | RER_54210 |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | RER_52890 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | RER_52850 RER_12090 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | RER_18360 RER_52840 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | RER_52910 RER_52080 |
CATB1 (NRULE_0386) | Muconate cycloisomerase | RER_54220 |
| D | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | RER_54230 |
CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | RER_54220 |
CATC (NRULE_0054) | Muconolactone isomerase | RER_54210 |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | RER_52890 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | RER_52850 RER_12090 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | RER_18360 RER_52840 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | RER_52080 RER_52910 |
Chlorocatechol degradation (beta-ketoadipate pathway)(NFUNC_0104) |
| 必須 | A | PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | RER_52850 RER_12090 |
|---|
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | RER_18360 RER_52840 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | RER_52080 RER_52910 |
CLCA (NRULE_0382) | Chlorocatechol 1,2-dioxygenase | |
CLCD (NRULE_0383) | Dienelactone hydrolase | RER_10210 RER_13330 RER_19100 RER_23200 RER_36120 RER_38020 RER_48500 RER_49870 RER_52940 RER_54620 RER_05570 RER_03140 |
CLCE (NRULE_0384) | Maleylacetate reductase | RER_08770 |
CLCB (NRULE_0387) | Chloromuconate cycloisomerase | |
| B | CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | RER_54220 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | RER_12090 RER_52850 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | RER_52840 RER_18360 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | RER_52910 RER_52080 |
CLCA (NRULE_0382) | Chlorocatechol 1,2-dioxygenase | |
CLCD (NRULE_0383) | Dienelactone hydrolase | RER_03140 RER_38020 RER_49870 RER_52940 RER_54620 RER_23200 RER_19100 RER_13330 RER_10210 RER_05570 RER_36120 RER_48500 |
CLCE (NRULE_0384) | Maleylacetate reductase | RER_08770 |
| 任意 | | CLCF (NRULE_0385) | Chloromuconolactone dehalogenase | |
|---|
Dibenzothiophene degradation (via desulfurization)(NFUNC_0029) |
| 必須 | A | DSZA (NRULE_0103) | Dibenzothiophene-5,5-dioxide monooxygenase | |
|---|
DSZB (NRULE_0104) | 2'-hydroxybiphenyl-2-sulfinate desulfinase | |
DSZC (NRULE_0105) | Dibenzothiophene monooxygenase | |
| 任意 | | FADR1 (NRULE_0101) | NADH-dependent flavin reductase | RER_10610 RER_13750 RER_17030 RER_45910 RER_48660 RER_54260 RER_07580 RER_05840 |
|---|
Dihydroxy aromatic compounds degradation (via meta-cleavage pathway)(NFUNC_0011) |
| 必須 | A | EDIO (NRULE_0058) | extradiol dioxygenase | RER_33580 RER_51660 RER_07570 RER_13780 |
|---|
METAH (NRULE_0059) | meta-cleavage compound hydrolase | RER_07560 |
HPDH (NRULE_0063) | 2-hydroxypent-2,4-dienoate hydratase | |
HOA (NRULE_0064) | 4-hydroxy-2-oxovalerate aldolase | RER_07410 RER_57580 |
ACDH (NRULE_0065) | Acetaldehyde dehydrogenase | RER_07400 RER_57570 |
| B | EDIO (NRULE_0058) | extradiol dioxygenase | RER_51660 RER_07570 RER_13780 RER_33580 |
2HMSD (NRULE_0060) | 2-hydroxymuconic semialdehyde dehydrogenase | RER_04700 RER_59330 |
4OT (NRULE_0061) | 4-oxalocrotonate tautomerase | |
4OD (NRULE_0062) | 4-oxalocrotonate decarboxylase | |
HPDH (NRULE_0063) | 2-hydroxypent-2,4-dienoate hydratase | |
HOA (NRULE_0064) | 4-hydroxy-2-oxovalerate aldolase | RER_57580 RER_07410 |
ACDH (NRULE_0065) | Acetaldehyde dehydrogenase | RER_07400 RER_57570 |
Ectoine biosynthesis(NFUNC_0056) |
| 必須 | A | ECTB (NRULE_0186) | Diaminobutyrate--2-oxoglutarate transaminase | RER_37860 |
|---|
ECTA (NRULE_0187) | L-2,4-diaminobutyric acid acetyltransferase | RER_37850 |
ECTC (NRULE_0188) | L-ectoine synthase | RER_37870 |
Folate biosynthesis(NFUNC_0044) |
| 必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | RER_00270 RER_18480 |
|---|
DHPS (NRULE_0144) | Dihydropteroate synthase | RER_41670 RER_06270 |
FOLM (NRULE_0146) | Dihydrofolate reductase FolM | |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | RER_06280 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | RER_06290 |
FOLC (NRULE_0160) | Bifunctional protein FolC | RER_37990 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | RER_18480 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | |
| B | GLAT (NRULE_0142) | Glutamine amidotransferase | RER_00270 RER_18480 |
DHPS (NRULE_0144) | Dihydropteroate synthase | RER_06270 RER_41670 |
FOLA (NRULE_0147) | Dihydrofolate reductase | RER_44620 |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | RER_06280 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | RER_06290 |
FOLC (NRULE_0160) | Bifunctional protein FolC | RER_37990 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | RER_18480 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | |
| C | GLAT (NRULE_0142) | Glutamine amidotransferase | RER_00270 RER_18480 |
DHPS (NRULE_0144) | Dihydropteroate synthase | RER_06270 RER_41670 |
DFR2 (NRULE_0148) | Dihydrofolate reductase type 2 | |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | RER_06280 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | RER_06290 |
FOLC (NRULE_0160) | Bifunctional protein FolC | RER_37990 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | RER_18480 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | |
GABA biosynthesis(NFUNC_0066) |
| 必須 | A | GAD (NRULE_0231) | Glutamate decarboxylase | RER_35380 |
|---|
Haloalkane degradation (conversion into hydroxyacid)(NFUNC_0010) |
| 必須 | A | DHAA (NRULE_0050) | Haloalkane dehalogenase | |
|---|
HAD (NRULE_0051) | (S)-2-haloacid dehalogenase | RER_59680 |
| B | DHAA (NRULE_0050) | Haloalkane dehalogenase | |
DEH (NRULE_0075) | Haloacetate dehalogenase | |
Human milk oligosaccharides metabolism(NFUNC_0083) |
| 必須 | A | LNBP (NRULE_0112) | 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase | |
|---|
| 任意 | | NAHK (NRULE_0256) | N-acetylhexosamine 1-kinase | |
|---|
| | GALT (NRULE_0110) | Galactose-1-phosphate uridylyltransferase | RER_55400 |
| | GALE (NRULE_0111) | UDP-glucose 4-epimerase | RER_31180 RER_28000 |
Hydroxyectoine biosynthesis(NFUNC_0057) |
| 必須 | A | ECTD (NRULE_0189) | Ectoine hydroxylase | |
|---|
| 任意 | | ECTB (NRULE_0186) | Diaminobutyrate--2-oxoglutarate transaminase | RER_37860 |
|---|
| | ECTA (NRULE_0187) | L-2,4-diaminobutyric acid acetyltransferase | RER_37850 |
| | ECTC (NRULE_0188) | L-ectoine synthase | RER_37870 |
4-hydroxyphenylacetate degradation(NFUNC_0068) |
| 必須 | A | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
|---|
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | RER_10630 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| B | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | RER_10630 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| C | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | RER_13750 RER_05840 RER_07580 RER_10610 RER_17030 RER_45910 RER_48660 RER_54260 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | RER_10630 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| D | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | RER_10610 RER_13750 RER_07580 RER_05840 RER_54260 RER_48660 RER_45910 RER_17030 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | RER_10630 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| E | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | RER_13750 RER_07580 RER_10610 RER_48660 RER_45910 RER_54260 RER_05840 RER_17030 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | RER_10630 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| F | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | RER_05840 RER_45910 RER_48660 RER_54260 RER_07580 RER_10610 RER_13750 RER_17030 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | RER_10630 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| G | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | RER_10630 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| H | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | RER_10630 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
Macrolide antibiotic resistance(NFUNC_0045) |
| 必須 | A | ERM (NRULE_0164) | rRNA adenine N-6-methyltransferase | |
|---|
| B | RLMA (NRULE_0165) | 23S rRNA (guanine-N(1))-methyltransferase | RER_41620 |
| C | MACA (NRULE_0166) | Macrolide-specific efflux protein MacA | |
MACB (NRULE_0167) | Macrolide export ATP-binding/permease protein MacB | |
| D | ERE (NRULE_0168) | Erythromycin esterase | RER_45200 |
| E | MPH (NRULE_0169) | Macrolide 2'-phosphotransferase | |
| F | MGT (NRULE_0170) | Macrolide glycosyltransferase | RER_10510 |
Metal-binding protein(NFUNC_0105) |
| 必須 | A | MOP (NRULE_0322) | Putative molybdenum-binding protein | RER_59040 RER_17930 RER_37530 RER_46690 RER_46720 |
|---|
| B | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | |
| C | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | RER_38730 RER_46710 RER_44420 RER_18370 |
| D | MNTR (NRULE_0327) | DtxR family transcriptional regulator MntR | |
| E | CUER (NRULE_0328) | Copper-responsive transcriptional regulator CueR | |
| F | SOXR (NRULE_0329) | Redox-sensitive transcriptional activator SoxR | RER_43780 RER_55040 |
| G | ZNTR (NRULE_0330) | Zinc-responsive transcriptional regulator ZntR | |
| H | NIKR (NRULE_0331) | Nickel-responsive transcriptional regulator NikR | |
| I | ISCR (NRULE_0332) | Rrf2 family transcriptional regulator IscR | |
| J | SMTA (NRULE_0009) | Metallothionein | |
Molybdate transport (ABC transporter)(NFUNC_0097) |
| 必須 | A | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | RER_18370 RER_44420 RER_46710 RER_38730 |
|---|
| 任意 | | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | |
|---|
| | MODB (NRULE_0325) | Molybdate ABC transporter permease protein | RER_46700 |
| | MODC (NRULE_0326) | Molybdate ABC transporter ATP-binding protein | |
Mycosamine biosynthesis(NFUNC_0095) |
| 必須 | A | AMPHDII (NRULE_0342) | GDP-3-keto-6-deoxy-D-mannose C-3 aminotransferase | |
|---|
GMD (NRULE_0343) | GDP-mannose 4,6-dehydratase | RER_13240 |
| 任意 | | AMPHDI (NRULE_0341) | GDP-mycosamine glycosyltransferase | |
|---|
Naphthalene degradation (via hydroxylation by dioxygenase)(NFUNC_0067) |
| 必須 | A | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | |
|---|
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
EDIO (NRULE_0058) | extradiol dioxygenase | RER_33580 RER_13780 RER_51660 RER_07570 |
NAHD (NRULE_0171) | 2-hydroxychromene-2-carboxylate isomerase | |
NAHE (NRULE_0172) | Trans-O-hydroxybenzylidenepyruvate hydratase-aldolase | |
NAHF (NRULE_0173) | Salicylaldehyde dehydrogenase | |
NAHG (NRULE_0190) | Salicylate hydroxylase | |
| B | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | |
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
EDIO (NRULE_0058) | extradiol dioxygenase | RER_51660 RER_07570 RER_13780 RER_33580 |
NAHD (NRULE_0171) | 2-hydroxychromene-2-carboxylate isomerase | |
NAHE (NRULE_0172) | Trans-O-hydroxybenzylidenepyruvate hydratase-aldolase | |
NAHF (NRULE_0173) | Salicylaldehyde dehydrogenase | |
NAGG (NRULE_0191) | Salicylate 5-hydroxylase alpha subunit | |
NAGH (NRULE_0192) | Salicylate 5-hydroxylase beta subunit | |
| 任意 | | FDR1 (NRULE_0032) | Oxygenase electron transfer component | RER_00070 RER_17750 RER_21780 RER_38520 RER_46640 RER_55460 |
|---|
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | RER_57010 RER_07540 RER_09150 RER_13800 RER_35970 RER_51130 RER_pREL1-01130 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | RER_pREL1-02840 RER_pREL1-02610 RER_07950 |
Nitrile hydratase(NFUNC_0002) |
| 必須 | A | NHAA (NRULE_0001) | Nitrile hydratase subunit alpha | RER_59240 |
|---|
NHAB (NRULE_0002) | Nitrile hydratase subunit beta | RER_59250 |
| 任意 | | P14K (NRULE_0006) | Nitrile hydratase activator P14K | |
|---|
| | COBW (NRULE_0007) | CobW/P47K family protein | RER_14090 RER_44020 RER_59260 RER_23350 |
(R)-pantothenate biosynthesis(NFUNC_0030) |
| 必須 | A | PAND (NRULE_0115) | Aspartate 1-decarboxylase | RER_06340 |
|---|
PANB (NRULE_0116) | 3-methyl-2-oxobutanoate hydroxymethyltransferase | RER_36510 |
PANE (NRULE_0117) | 2-dehydropantoate 2-reductase | |
PANC (NRULE_0118) | Pantothenate synthetase | RER_06330 |
Phenol degradation(NFUNC_0028) |
| 必須 | A | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | |
|---|
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | |
MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
| B | PHEA1 (NRULE_0083) | Aromatic ring hydroxylase | RER_54270 |
| C | PHEA2 (NRULE_0084) | Aromatic ring hydroxylase | |
| 任意 | | FDR2 (NRULE_0057) | Ferredoxin reductase | RER_pREL1-02840 RER_07950 RER_pREL1-02610 |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | RER_46640 RER_00070 RER_17750 RER_38520 RER_55460 RER_21780 |
| | MME (NRULE_0033) | Multicomponent monooxygenase effector protein | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | RER_51130 RER_pREL1-01130 RER_07540 RER_09150 RER_13800 RER_57010 RER_35970 |
| | FADR1 (NRULE_0101) | NADH-dependent flavin reductase | RER_17030 RER_45910 RER_48660 RER_54260 RER_10610 RER_07580 RER_05840 RER_13750 |
Protocatechuate degradation (beta-ketoadipate pathway)(NFUNC_0014) |
| 必須 | A | PCAG (NRULE_0066) | Protocatechuate 3,4-dioxygenase alpha subunit | RER_52870 |
|---|
PCAH (NRULE_0067) | Protocatechuate 3,4-dioxygenase beta subunit | RER_52860 |
PCAB (NRULE_0068) | 3-carboxy-cis,cis-muconate cycloisomerase | RER_52880 |
PCAC (NRULE_0069) | 4-carboxymuconolactone decarboxylase | RER_52890 |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | RER_52890 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | RER_12090 RER_52850 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | RER_18360 RER_52840 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | RER_52080 RER_52910 |
| B | PCAG (NRULE_0066) | Protocatechuate 3,4-dioxygenase alpha subunit | RER_52870 |
PCAH (NRULE_0067) | Protocatechuate 3,4-dioxygenase beta subunit | RER_52860 |
PCAB (NRULE_0068) | 3-carboxy-cis,cis-muconate cycloisomerase | RER_52880 |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | RER_52890 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | RER_52850 RER_12090 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | RER_52840 RER_18360 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | RER_52910 RER_52080 |
Riboflavin biosynthesis(NFUNC_0058) |
| 必須 | A | RIBB (NRULE_0200) | 3,4-dihydroxy-2-butanone 4-phosphate synthase | RER_30220 |
|---|
RIBA (NRULE_0201) | GTP cyclohydrolase-2 | RER_30220 |
RIBD (NRULE_0202) | Riboflavin biosynthesis protein RibD | |
RIBH (NRULE_0203) | 6,7-dimethyl-8-ribityllumazine synthase | RER_40200 RER_30230 |
RIBE (NRULE_0204) | Riboflavin synthase | RER_30210 |
| 任意 | | RIBF (NRULE_0205) | Riboflavin biosynthesis protein RibF | RER_26420 |
|---|
Thiocyanate hydrolase(NFUNC_0003) |
| 必須 | A | SCNA (NRULE_0003) | Thiocyanate hydrolase subunit alpha | RER_59250 |
|---|
SCNB (NRULE_0004) | Thiocyanate hydrolase subunit beta | RER_59250 |
SCNC (NRULE_0005) | Thiocyanate hydrolase subunit gamma | |
| B | SCNA (NRULE_0003) | Thiocyanate hydrolase subunit alpha | RER_59250 |
SCNC (NRULE_0005) | Thiocyanate hydrolase subunit gamma | |
| C | SCNB (NRULE_0004) | Thiocyanate hydrolase subunit beta | RER_59250 |
SCNC (NRULE_0005) | Thiocyanate hydrolase subunit gamma | |
Toluene degradation (conversion into benzoate)(NFUNC_0009) |
| 必須 | A | XYLA (NRULE_0025) | Xylene monooxygenase electron transfer component | |
|---|
XYLM (NRULE_0026) | Xylene monooxygenase | |
BADH (NRULE_0042) | Aryl-alcohol dehydrogenase | RER_07910 |
BZDH1 (NRULE_0043) | Benzaldehyde dehydrogenase | RER_55880 |
| B | XYLA (NRULE_0025) | Xylene monooxygenase electron transfer component | |
XYLM (NRULE_0026) | Xylene monooxygenase | |
BADH (NRULE_0042) | Aryl-alcohol dehydrogenase | RER_07910 |
BZDH2 (NRULE_0381) | NAD(P)-dependent benzaldehyde dehydrogenase | |
Toluene degradation (conversion into protocatechuate via p-cresol)(NFUNC_0007) |
| 必須 | A | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | |
|---|
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | |
FDR1 (NRULE_0032) | Oxygenase electron transfer component | RER_00070 RER_17750 RER_21780 RER_38520 RER_46640 RER_55460 |
MME (NRULE_0033) | Multicomponent monooxygenase effector protein | |
PCHF (NRULE_0035) | 4-cresol dehydrogenase flavoprotein subunit | |
PCHC (NRULE_0036) | 4-cresol dehydrogenase cytochrome c subunit | |
PCHA (NRULE_0037) | p-hydroxybenzaldehyde dehydrogenase | |
POBA (NRULE_0038) | p-hydroxybenzoate hydroxylase | |
| 任意 | | MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
|---|
| | MMG2 (NRULE_0030) | Multicomponent monooxygenase gamma subunit | |
| | MMG3 (NRULE_0031) | Multicomponent monooxygenase gamma subunit | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | RER_09150 RER_07540 RER_51130 RER_35970 RER_13800 RER_57010 RER_pREL1-01130 |
Trehalose biosynthesis (from maltooligosaccharide)(NFUNC_0037) |
| 必須 | A | TREY (NRULE_0140) | Maltooligosyl trehalose synthase | RER_35070 |
|---|
TREZ (NRULE_0141) | Malto-oligosyltrehalose trehalohydrolase | RER_35240 |
| 任意 | | GLGX (NRULE_0139) | Glycogen debranching enzyme | RER_23610 RER_35060 |
|---|
Trehalose biosynthesis (from NDP-glucose and glucose-6-phosphate)(NFUNC_0031) |
| 必須 | A | TPS (NRULE_0119) | Trehalose-phosphate synthase | RER_12840 RER_09680 |
|---|
TPP (NRULE_0120) | Trehalose-6-phosphate phosphatase | RER_07050 RER_29400 RER_34080 |
Uptake of osmoprotectant(NFUNC_0061) |
| 必須 | A | OPUAC (NRULE_0213) | Osmoprotectant ABC transporter substrate-binding protein | |
|---|
OPUAB (NRULE_0214) | Osmoprotectant ABC transporter permease protein | |
OPUAA (NRULE_0215) | Osmoprotectant ABC transporter ATP-binding protein | |
| B | EHUB (NRULE_0216) | Ectoine ABC transporter substrate-binding protein | |
EHUC (NRULE_0217) | Ectoine ABC transporter permease protein | |
EHUD (NRULE_0218) | Ectoine ABC transporter permease protein | |
EHUA (NRULE_0219) | Ectoine ABC transporter ATP-binding protein | |
| C | BCCT (NRULE_0220) | BCCT family transporter | RER_05440 RER_43710 |
| D | PROP (NRULE_0221) | Osmoprotectant transporter | |
| E | OPUE (NRULE_0222) | Sodium/proline symporter | |
| F | TEAA (NRULE_0223) | TRAP transporter substrate-binding protein TeaA | |
TEAB (NRULE_0224) | TRAP transporter small transmembrane protein TeaB | |
TEAC (NRULE_0225) | TRAP transporter large transmembrane protein TeaC | |
Vitamin B6 biosynthesis (PdxA/PdxJ pathway)(NFUNC_0060) |
| 必須 | A | EPD (NRULE_0208) | D-erythrose-4-phosphate dehydrogenase | |
|---|
PDXB (NRULE_0209) | Erythronate-4-phosphate dehydrogenase | |
SERC (NRULE_0210) | Phosphoserine aminotransferase | RER_46170 |
PDXA (NRULE_0211) | 4-hydroxythreonine-4-phosphate dehydrogenase | RER_05270 |
PDXJ (NRULE_0212) | Pyridoxine 5'-phosphate synthase | |
Vitamin B6 biosynthesis (PdxS/PdxT pathway)(NFUNC_0059) |
| 必須 | A | PDXS (NRULE_0206) | Pyridoxal biosynthesis lyase PdxS | RER_29090 |
|---|
PDXT (NRULE_0207) | Glutamine amidotransferase subunit PdxT | RER_29150 |
