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Rule : 8-amino-7-oxononanoate synthase (BIOF)

Rule Description

ID NRULE_0182
Rule name BIOF
Created 2013-03-27
Protein name
Protein name
Full
8-amino-7-oxononanoate synthase
Short
AONS
EC
EC 2.3.1.47
Synonym
Full
7-keto-8-amino-pelargonic acid synthase
8-amino-7-ketopelargonate synthase
L-alanine--pimeloyl-CoA ligase
Short
7-KAP synthase
Gene name bioF
Rule Trigger TIGRFAMs; TIGR00858; hit=1
Cross Reference
Gene Ontology
GO
GO:0008710, F:8-amino-7-oxononanoate synthase activity, IDA:EcoCyc
GO:0030170, F:pyridoxal phosphate binding, IDA:UniProtKB
GO:0009102, P:biotin biosynthetic process, IMP:EcoCyc
Phylogenomic databases
eggNOG
COG0156, -
HOGENOM
HOG000221021, -
KO
K00652, -
ProtClustDB
PRK05958, -
Enzyme and pathway databases
BioCyc
MetaCyc:7KAPSYN-MONOMER, -
UniPathway
UPA00078, UER00159
Family and domain databases
HAMAP
MF_01693, BioF_aminotrans_2, 1, -
InterPro
IPR022834, Amino_oxononanoate_synth
IPR001917, Aminotrans_II_pyridoxalP_BS
IPR004839, Aminotransferase_I/II
IPR004723, BioF
IPR015424, PyrdxlP-dep_Trfase
IPR015421, PyrdxlP-dep_Trfase_major_sub1
IPR015422, PyrdxlP-dep_Trfase_major_sub2
Pfam
PF00155, Aminotran_1_2, 1
TIGRFAMs
TIGR00858, bioF, 1
PROSITE
PS00599, AA_TRANSFER_CLASS_2, 1
Feature
P12998 Escherichia coli (strain K12).
BINDING21Substrate.
BINDING133Substrate.
BINDING179Pyridoxal phosphate.
BINDING352Substrate.
MOD_RES236N6-(pyridoxal phosphate)lysine.
General annotation
Function
Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide
Catalytic activity
6-carboxyhexanoyl-CoA + L-alanine = 8-amino-7- oxononanoate + CoA + CO(2)
Cofactor
Pyridoxal phosphate
Pathway
Cofactor biosynthesis; biotin biosynthesis; 8-amino-7- oxononanoate from pimeloyl-CoA: step 1/1
Subunit structure
Homodimer
Sequence similarities
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily
Reference
P12998 Escherichia coli (strain K12).
3058702
The Escherichia coli biotin biosynthetic enzyme sequences predicted from the nucleotide sequence of the bio operon. (J Biol Chem. 1988)



Related Function

Function name
Biotin biosynthesis

CDS

Data Download
Scientific name NBRC No. CDS Product name
Acaryochloris marina102967AM1_22968-amino-7-oxononanoate synthase
Acetobacter aceti14818AaceN1_0101000051618-amino-7-oxononanoate synthase
Acidiphilium multivorum100883ACMV_210908-amino-7-oxononanoate synthase
Acidithiobacillus ferrooxidansLferr_04198-amino-7-oxononanoate synthase
Acidobacterium capsulatum15755ACP_19168-amino-7-oxononanoate synthase
Alicyclobacillus acidocaldarius subsp. acidocaldarius15652Aaci_28568-amino-7-oxononanoate synthase
Anaerolinea thermophila100420ANT_301608-amino-7-oxononanoate synthetase
Anoxybacillus flavithermus15317Aflv_11637-keto-8-aminopelargonate synthetase
Aquifex aeolicusaq_6268-amino-7-oxononanoate synthase
Bacillus amyloliquefaciens15535BAMF_17722-amino-3-ketobutyrate CoA ligase (glycine acetyl transferase)
BAMF_19228-amino-7-oxononanoate synthase
Bacillus atrophaeus13721BATRMS_05_007808-amino-7-oxononanoate synthase
BATRMS_10_006302-amino-3-ketobutyrate CoA ligase
Bacillus cereus15305BC_41178-amino-7-oxononanoate synthase
Bacillus licheniformis12200BL009548-amino-7-oxononanoate synthase
BL036592-amino-3-ketobutyrate CoA ligase (glycine acetyl transferase)
Bacillus licheniformis12195BLi007688-amino-7-oxononanoate synthase BioF
BLi019242-amino-3-ketobutyrate CoA ligase Kbl
Bacillus mojavensis15718GYU_01_004708-amino-7-oxononanoate synthase
Bacillus mycoides101228bmyco0001_37440KAPA synthase-II
Bacillus pseudomycoides101232bpmyx0001_36000KAPA synthase-II
Bacillus psychrosaccharolyticus101233WYK_258_00150pyridoxal phosphate-dependent acyltransferase
Bacillus pumilus12092BAT_24218-amino-7-oxononanoate synthase
Bacillus subtilis3134BSU6633_074312-amino-3-ketobutyrate coenzyme A ligase
BSU6633_128778-amino-7-oxononanoate synthase
Bacillus subtilis subsp. subtilis13719BSU170002-amino-3-ketobutyrate CoA ligase (glycine acetyl transferase)
BSU302208-amino-7-oxononanoate synthase
Bacillus thuringiensis101235bthur0008_39100KAPA synthase-II
Bacillus vallismortis101236BvalD_0101000037042-amino-3-ketobutyrate coenzyme A ligase
BvalD_0101000102458-amino-7-oxononanoate synthase
Balneola vulgarisB155_RS01020258-amino-7-oxononanoate synthase
Brevibacillus brevis100599BBR47_546108-amino-7-oxononanoate synthase
Caldilinea aerophila104270CLDAP_249308-amino-7-oxononanoate synthetase
Caldisericum exile104410CSE_048002-amino-3-ketobutyrate coenzyme A ligase
Candidatus Solibacter usitatusAcid_51662-amino-3-ketobutyrate coenzyme A ligase
Caulobacter segnis15250Cseg_26278-amino-7-oxononanoate synthase
Chloracidobacterium thermophilum BCabther_A03328-amino-7-oxononanoate synthase
Chromobacterium violaceum12614CV_43808-amino-7-oxononanoate synthase
Chthoniobacter flavusCfE428DRAFT_33348-amino-7-oxononanoate synthase
Chthonomonas calidiroseaCCALI_012712-amino-3-ketobutyrate coenzyme A ligase
Clostridium thermocellum103400Cthe_00228-amino-7-oxononanoate synthase
Conexibacter woesei100937Cwoe_04248-amino-7-oxononanoate synthase
Cwoe_15708-amino-7-oxononanoate synthase
Cupriavidus metallidurans102507Rmet_01158-amino-7-oxononanoate synthase
Cystobacter fuscus100088D187_0003138-amino-7-oxononanoate synthase
Deferribacter desulfuricans101012DEFDS_13018-amino-7-oxononanoate synthase
Deinococcus proteolyticus101906Deipr_1996pyridoxal phosphate-dependent acyltransferase
Desulfovibrio magneticus104933DMR_189808-amino-7-oxononanoate synthase
Edwardsiella tarda105688ET1_08_001808-amino-7-oxononanoate synthase
Enterobacter aerogenes13534EAE_144508-amino-7-oxononanoate synthase
Enterobacter cloacae subsp. cloacae13535ECL_029608-amino-7-oxononanoate synthase
Enterobacter hormaechei105718HMPREF9086_10848-amino-7-oxononanoate synthase
Escherichia coli3972EcolC_28678-amino-7-oxononanoate synthase
Escherichia coli13500WFL_040308-amino-7-oxononanoate synthase
Escherichia coli12713Y75_07538-amino-7-oxononanoate synthase
Escherichia fergusonii102419EFER_23378-amino-7-oxononanoate synthase
Escherichia hermannii105704EH105704_23_001308-amino-7-oxononanoate synthase
Fibrobacter succinogenesFisuc_29558-amino-7-oxononanoate synthase
Fimbriimonas ginsengisoliOP10G_0224pyridoxal phosphate-dependent acyltransferase
Fischerella sp.PCC9339_RS01131008-amino-7-oxononanoate synthase
Frateuria aurantia3245Fraau_01758-amino-7-oxononanoate synthase
Gemmatimonas aurantiaca100505GAU_28408-amino-7-oxononanoate synthase
Gloeobacter violaceusgll03977-keto-8-aminopelargonic acid synthetase
Halobacillus halophilus102448HBHAL_3115pyridoxal phosphate-dependent acyltransferase
Halomonas elongata15536HELO_21698-amino-7-oxononanoate synthase
Haloplasma contractileHLPCO_002015glycine C-acetyltransferase protein
Klebsiella pneumoniae subsp. rhinoscleromatis105682HMPREF0484_13798-amino-7-oxononanoate synthase
Kyrpidia tusciae15312Btus_25978-amino-7-oxononanoate synthase
Limnochorda pilosa110152LIP_01862-amino-3-ketobutyrate CoA ligase
Marinomonas mediterranea103028Marme_32508-amino-7-oxononanoate synthase
Methanocaldococcus jannaschii100440MJ_12988-amino-7-oxononanoate synthase (bioF)
Nitriliruptor alkaliphilusNitalDRAFT_49648-amino-7-oxononanoate synthase
Nitrosomonas europaea14298NE2299Aminotransferases class-I
Nostoc sp.all0374 bioF gene product
Oceanithermus profundus100410Ocepr_1812pyridoxal phosphate-dependent acyltransferase
Paenibacillus alvei3343PAV_1c044708-amino-7-oxononanoate synthase
Paenibacillus peoriae15541PpeoK3_0101000152268-amino-7-oxononanoate synthase
Pelobacter carbinolicus103641Pcar_16658-amino-7-oxononanoate synthase
Pelobacter propionicus103807Ppro_20938-amino-7-oxononanoate synthase
Photobacterium damselae subsp. damselae corrig.15633VDA_0022978-amino-7-oxononanoate synthase
Proteus mirabilis105697HMPREF0693_19578-amino-7-oxononanoate synthase
Providencia alcalifaciens105687PROVALCAL_032588-amino-7-oxononanoate synthase
Pseudomonas putida100650PP_03638-amino-7-oxononanoate synthase
Pseudomonas stutzeri14165PSTAB_38168-amino-7-oxononanoate synthase
Pyrococcus horikoshii100139PH0292.1pyridoxal-phosphate-dependent glycine acetyltransferase
Rahnella aquatilis105701Rahaq2_31238-amino-7-oxononanoate synthase
Selenomonas ruminantium subsp. lactilytica103574SELR_030606-carboxyhexanoate-CoA ligase/8-amino-7-oxononanoate synthase
Serratia odorifera102598HMPREF0758_47978-amino-7-oxononanoate synthase
Shimwellia blattae105725EB105725_03_002608-amino-7-oxononanoate synthase
Synechocystis sp.slr09177-keto-8-aminopelargonic acid synthetase
Thauera linaloolentis102519C666_079058-amino-7-oxononanoate synthase
Thermodesulfovibrio yellowstoniiTHEYE_A13338-amino-7-oxononanoate synthase
Thermotoga thermarum107925Theth_19862-amino-3-ketobutyrate coenzyme A ligase
Thermus thermophilus101084TTHA15822-amino-3-ketobutyrate CoA ligase (glycine acetyltransferase)
Thermus thermophilus101085TT_C1219probable glycine C-acetyltransferase
Vibrio alginolyticus15630N646_01658-amino-7-oxononanoate synthase
Vibrio ichthyoenteri15847VII00023_151268-amino-7-oxononanoate synthase
Vibrio metschnikovii103153VIB_0014958-amino-7-oxononanoate synthase
Vibrio orientalis15638VIOR3934_032178-amino-7-oxononanoate synthase
Vibrio tubiashii15644VITU9109_163488-amino-7-oxononanoate synthase
Xenococcus sp.Xen7305DRAFT_000412008-amino-7-oxononanoate synthase
Yersinia bercovieri105717yberc0001_276608-amino-7-oxononanoate synthase
Yersinia rohdei105715yrohd0001_360208-amino-7-oxononanoate synthase