遺伝子 : GDP-mannose 4,6-dehydratase (GMD)

遺伝子情報

ID	NRULE_0343
遺伝子ID	GMD
作成日	2015/07/16
タンパク質名	Protein name Full GDP-mannose 4,6-dehydratase EC EC 4.2.1.47 Synonym Full GDP-D-mannose dehydratase
遺伝子名	gmd
遺伝子条件	HAMAP; MF_00955; hit=1
参照	Gene Ontology GO GO:0005622, C:intracellular, IEA:InterPro GO:0008446, F:GDP-mannose 4,6-dehydratase activity, IEA:UniProtKB-HAMAP GO:0070401, F:NADP+ binding, IEA:UniProtKB-HAMAP GO:0019673, P:GDP-mannose metabolic process, IEA:InterPro Family and domain databases HAMAP MF_00955, GDP_Man_dehydratase, 1 InterPro IPR001509, Epimerase_deHydtase IPR006368, GDP_Man_deHydtase IPR016040, NAD(P)-bd_dom Pfam PF01370, Epimerase, 1
配列の特徴	Q9L4X4 Streptomyces noursei. NP_BIND 9 - 14 NADP. NP_BIND 57 - 58 NADP. NP_BIND 79 - 83 NADP. ACT_SITE 135   ACT_SITE 137 Nucleophile. ACT_SITE 159 Nucleophile. BINDING 163 NADP. BINDING 189 NADP. BINDING 194 NADP. P0AC88 Escherichia coli (strain K12). NP_BIND 9 - 14 NADP. NP_BIND 64 - 65 NADP. NP_BIND 86 - 90 NADP. ACT_SITE 133   ACT_SITE 135 Nucleophile. ACT_SITE 157 Nucleophile. BINDING 101 NADP. BINDING 161 NADP. BINDING 187 NADP. BINDING 192 NADP.
注釈	Function Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose Catalytic activity GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H(2)O Cofactor NADP Sequence similarities Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily
参考文献	Q9L4X4 Streptomyces noursei. 10873841 Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: analysis of the gene cluster and deduction of the biosynthetic pathway. (Chem Biol. 2000) 17905880 Analysis of the mycosamine biosynthesis and attachment genes in the nystatin biosynthetic gene cluster of Streptomyces noursei ATCC 11455. (Appl Environ Microbiol. 2007) P0AC88 Escherichia coli (strain K12). 9257704 Expression, purification and characterization of GDP-D-mannose 4,6-dehydratase from Escherichia coli. (FEBS Lett. 1997) 10673432 Structural and kinetic analysis of Escherichia coli GDP-mannose 4,6 dehydratase provides insights into the enzyme's catalytic mechanism and regulation by GDP-fucose. (Structure. 2000)

関与する機能

機能名
Mycosamine biosynthesis

該当CDS

学名	NBRC番号	CDS	タンパク質名
Acaryochloris marina	102967	AM1_5749	GDP-mannose 4,6-dehydratase
Acidimicrobium ferrooxidans	103882	Afer_0331	GDP-mannose 4,6-dehydratase
Acidiphilium multivorum	100883	ACMV_05830	GDP-mannose 4,6-dehydratase
Acidithiobacillus ferrooxidans		Lferr_2592	GDP-mannose 4,6-dehydratase
		Lferr_2890	GDP-mannose 4,6-dehydratase
Alteromonas macleodii	102226	MASE_16660	GDP-mannose-4,6-dehydratase
Amycolatopsis mediterranei	13415	RAM_00585	GDPmannose 4,6-dehydratase
Anaerolinea thermophila	100420	ANT_09960	GDP-mannose 4,6-dehydratase
Aquifex aeolicus		aq_1082	GDP-D-mannose dehydratase
Aquimarina agarilytica	107695	AagaZ_020100006010	GDP-mannose 4,6-dehydratase
Ardenticatena maritima		ARMA_0944	GDPmannose 4,6-dehydratase
Arthrobacter globiformis	12137	ARGLB_064_00950	GDP-mannose 4,6-dehydratase
Azorhizobium caulinodans	14845	AZC_0054	GDP-mannose 4,6-dehydratase
Bacteroides vulgatus	14291	BVU_2652	GDP-mannose 4,6-dehydratase
		BVU_3946	GDP-mannose 4,6-dehydratase
Bradyrhizobium diazoefficiens	14792	bll1631	GDP-mannose 4,6-dehydratase
		bll5465	GDP-mannose 4,6-dehydratase
Brevibacillus brevis	100599	BBR47_17580	GDP-mannose 4,6-dehydratase
Brevundimonas subvibrioides	16000	Bresu_3278	GDP-mannose 4,6-dehydratase
Caldilinea aerophila	104270	CLDAP_05850	GDP-mannose 4,6-dehydratase
Calditerrivibrio nitroreducens	101217	Calni_1168	GDP-mannose 4,6-dehydratase
		Calni_1961	GDP-mannose 4,6-dehydratase
Candidatus Solibacter usitatus		Acid_1019	NAD-dependent epimerase/dehydratase
		Acid_4632	GDP-mannose 4,6-dehydratase
Caulobacter segnis	15250	Cseg_0512	GDP-mannose 4,6-dehydratase
Cellulomonas flavigena	3775	Cfla_2366	NAD-dependent epimerase/dehydratase
		Cfla_2367	GDP-mannose 4,6-dehydratase
Cellulophaga lytica	14961	Celly_2619	GDP-mannose 4,6-dehydratase
Chitinispirillum alkaliphilum		CHISP_2348	GDP-mannose 4,6-dehydratase
Chitinophaga pinensis	15968	Cpin_1090	GDP-mannose 4,6-dehydratase
		Cpin_2364	GDP-mannose 4,6-dehydratase
Chloracidobacterium thermophilum B		Cabther_A2234	GDP-mannose 4,6-dehydratase
Chrysiogenes arsenatis		P304_RS0112330	GDP-mannose 4,6-dehydratase
Chthoniobacter flavus		CfE428DRAFT_2886	GDP-mannose 4,6-dehydratase
Chthonomonas calidirosea		CCALI_02421	GDP-mannose 4,6-dehydratase
Clostridium acetobutylicum	13948	CA_C2180	GDP-D-mannose dehydratase
Conexibacter woesei	100937	Cwoe_5497	GDP-mannose 4,6-dehydratase
Coraliomargarita akajimensis		Caka_2418	GDP-mannose 4,6-dehydratase
Cupriavidus metallidurans	102507	Rmet_5860	GDP-D-mannose dehydratase, NAD(P)-binding
Cytophaga hutchinsonii	15051	CHU_0059	GDP-D-mannose dehydratase
Desulfovibrio magneticus	104933	DMR_26790	GDP-mannose 4,6-dehydratase
		DMR_26800	GDP-mannose 4,6-dehydratase
Desulfovibrio vulgaris subsp. vulgaris	104121	DVU_0448	GDP-mannose 4,6-dehydratase
Enterobacter cloacae subsp. cloacae	13535	ECL_03376	GDPmannose 4,6-dehydratase
Enterobacter hormaechei	105718	HMPREF9086_3040	GDP-mannose 4,6-dehydratase
Escherichia coli	3972	EcolC_1588	GDP-mannose 4,6-dehydratase
Escherichia coli	13500	WFL_10825	GDP-mannose 4,6-dehydratase
Escherichia coli	12713	Y75_2047	GDP-D-mannose dehydratase, NAD(P)-binding
Escherichia fergusonii	102419	EFER_2118	GDP-D-mannose dehydratase, NAD(P)-binding
		EFER_2137	GDP-D-mannose dehydratase, NAD(P)-binding
Escherichia hermannii	105704	EH105704_03_00450	GDP-mannose 4,6-dehydratase
		EH105704_03_00630	GDP-mannose 4,6-dehydratase
Fimbriimonas ginsengisoli		OP10G_3266	GDP-mannose 4,6-dehydratase
		OP10G_3292	GDP-mannose 4,6-dehydratase
Fischerella sp.		PCC9339_RS0121120	GDP-mannose 4,6-dehydratase
		PCC9339_RS0125345	GDP-mannose 4,6-dehydratase
Flavobacterium johnsoniae	14942	Fjoh_0330	GDP-mannose 4,6-dehydratase
Flexibacter litoralis	15988	Fleli_3688	GDP-mannose 4,6-dehydratase
Gemmata obscuriglobus		GEMOB_RS20065	GDP-mannose 4,6-dehydratase
Gemmatimonas aurantiaca	100505	GAU_1970	GDP-mannose 4,6-dehydratase
Gloeobacter violaceus		gll0763	GDP-D-mannose dehydratase
		gll0764	GDP-D-mannose dehydratase
Gordonia alkanivorans	16433	GOALK_050_03210	GDP-mannose 4,6-dehydratase
Gordonia amarae	15530	GOAMR_46_00890	GDP-mannose 4,6-dehydratase
Gordonia amicalis	100051	GOAMI_08_00300	GDP-mannose 4,6-dehydratase
Gordonia namibiensis	108229	GONAM_04_00060	GDP-mannose 4,6-dehydratase
Gordonia otitidis	100426	GOOTI_090_00160	GDP-mannose 4,6-dehydratase
Gordonia polyisoprenivorans	16320	GOPIP_088_00090	GDP-mannose 4,6-dehydratase
Gordonia rhizosphera	16068	GORHZ_127_00330	GDP-mannose 4,6-dehydratase
Gordonia sputi	100414	GOSPT_125_00670	GDP-mannose 4,6-dehydratase
Gordonia terrae	100016	GOTRE_067_00120	GDP-mannose 4,6-dehydratase
Herpetosiphon aurantiacus		Haur_4567	GDP-mannose 4,6-dehydratase
Hylemonella gracilis	14920	HGR_06866	GDP-mannose 4,6-dehydratase
Hyphomonas neptunium	14232	HNE_0793	GDP-mannose 4,6-dehydratase
Ignavibacterium album	101810	IALB_2463	GDP-D-mannose dehydratase
		IALB_3153	GDP-D-mannose dehydratase
Kineococcus radiotolerans	101839	Krad_1827	GDP-mannose 4,6-dehydratase
Kocuria rhizophila	103217	KRH_20460	GDP-mannose 4,6-dehydratase
Kribbella flavida	14399	Kfla_2743	GDP-mannose 4,6-dehydratase
Leadbetterella byssophila	106382	Lbys_2464	GDP-mannose 4,6-dehydratase
		Lbys_2927	GDP-mannose 4,6-dehydratase
Lentisphaera araneosa		LNTAR_04406	GDP-D-mannose dehydratase in colanic acid gene cluster
		LNTAR_14477	subunit of GDP-mannose 4,6-dehydratase
Leptospira interrogans		LA_3964	GDP-mannose 4,6-dehydratase
Limnochorda pilosa	110152	LIP_2246	GDP-D-mannose dehydratase
		LIP_2263	GDP-mannose 4,6-dehydratase
Marinomonas mediterranea	103028	Marme_0625	GDP-mannose 4,6-dehydratase
		Marme_2110	GDP-mannose 4,6-dehydratase
Mariprofundus ferrooxydans		SPV1_00522	NAD-dependent epimerase/dehydratase
		SPV1_07586	GDP-D-mannose dehydratase
Methanocella paludicola	101707	MCP_2715	GDP-mannose 4,6-dehydratase
Methanococcus maripaludis		MmarC5_1306	GDP-mannose 4,6-dehydratase
Methylobacterium radiotolerans	15690	Mrad2831_0173	GDP-mannose 4,6-dehydratase
Microscilla marina	16560	M23134_05650	GDP-mannose 4,6-dehydratase
Niastella koreensis	106392	Niako_0082	GDP-mannose 4,6-dehydratase
		Niako_6778	GDP-mannose 4,6-dehydratase
		Niako_6783	GDP-mannose 4,6-dehydratase
Nitriliruptor alkaliphilus		NitalDRAFT_3073	GDPmannose 4,6-dehydratase
Nitrospina gracilis		NITGR_10026	GDP-mannose 4,6-dehydratase
Nostoc sp.		alr3424	GDP-mannose 4,6-dehydratase
Ochrobactrum anthropi	15819	Oant_3372	GDP-mannose 4,6-dehydratase
Ochrobactrum intermedium	15820	OINT_2000454	GDP-mannose 4,6-dehydratase
Paenibacillus peoriae	15541	PpeoK3_010100025274	GDP-mannose 4,6-dehydratase
Paenibacillus polymyxa	15309	PPT_05795	GDP-mannose 4,6-dehydratase
Pedobacter heparinus	12017	Phep_4001	GDP-mannose 4,6-dehydratase
Pedobacter saltans	100064	Pedsa_3226	GDP-mannose 4,6-dehydratase
Pelobacter propionicus	103807	Ppro_3405	GDP-mannose 4,6-dehydratase
Phaeobacter gallaeciensis	16654	PGA1_65p00310	GDP-mannose 4,6-dehydratase Gmd
		PGA1_c02320	GDP-mannose 4,6-dehydratase Gmd
Phycisphaera mikurensis	102666	PSMK_23130	GDP-mannose 4,6-dehydratase
Planctomyces brasiliensis	103401	Plabr_0480	GDP-mannose 4,6-dehydratase
		Plabr_1311	GDP-mannose 4,6-dehydratase
		Plabr_4205	GDP-mannose 4,6-dehydratase
Prochlorococcus marinus subsp. marinus		Pro_0063	GDP-D-mannose dehydratase
Pseudomonas putida	100650	PP_1799	GDP-mannose 4,6 dehydratase
Rahnella aquatilis	105701	Rahaq2_0609	GDP-mannose 4,6-dehydratase
Renibacterium salmoninarum	15589	RSal33209_1341	GDP-mannose 4,6 dehydratase
Rhizobium etli	15573	RHE_CH00762	GDP-mannose 4,6-dehydratase protein
		RHE_CH01350	GDP-mannose 4,6-dehydratase protein
Rhizobium sp.	101917	NGR_a00410	GDP-mannose 4,6, dehydratase; nodulation protein NoeL
Rhizobium tropici	15247	RTCIAT899_CH18290	GDP-mannose 4,6-dehydratase
Rhodobacter sphaeroides	12203	RSP_4109	NAD-dependent epimerase/dehydratase
Rhodococcus erythropolis	100887	RER_13240	GDP-mannose 4,6-dehydratase
Rhodococcus opacus	108011	ROP_pKNR-00800	GDP-mannose 4,6-dehydratase
Roseobacter litoralis	15278	RLO149_c044290	GDP-mannose 4,6-dehydratase Gmd
Rubrobacter xylanophilus	100952	Rxyl_0567	GDP-mannose 4,6-dehydratase
Saccharomonospora glauca	14831	SacglDRAFT_00126	GDP-mannose 4,6-dehydratase
Saccharomonospora viridis	12207	Svir_00720	GDP-mannose 4,6-dehydratase
Saccharothrix espanaensis	15066	BN6_00650	GDP-mannose 4,6-dehydratase
Selenomonas ruminantium subsp. lactilytica	103574	SELR_17260	putative GDP-mannose 4,6-dehydratase
Solitalea canadensis	15130	Solca_4302	GDP-mannose 4,6-dehydratase
Sphingobacterium spiritivorum	14948	HMPREF0766_10715	GDP-mannose 4,6-dehydratase
Sphingobium japonicum	101211	SJA_C1-30270	GDP-mannose 4,6-dehydratase
Sphingobium sp.	103272	SLG_10180	GDP-mannose 4,6-dehydratase
Sporichthya polymorpha	12702	Spopo_31_21120	GDP-D-mannose dehydratase
Starkeya novella	14993	Snov_3771	NAD-dependent epimerase/dehydratase
Streptomyces mobaraensis	13819	H340_24665	GDP-mannose 4,6-dehydratase
Streptomyces purpureus	13925	STRPU_17_02050	GDP-mannose 4,6-dehydratase
Streptosporangium roseum	3776	Sros_8229	GDP-mannose 4,6-dehydratase
Synechococcus elongatus		Synpcc7942_1342	GDP-mannose 4,6-dehydratase
Synechocystis sp.		sll1212	GDP-D-mannose dehydratase
Thauera linaloolentis	102519	C666_04235	GDP-mannose 4,6-dehydratase
Thermanaerovibrio acidaminovorans		Taci_0017	GDP-mannose 4,6-dehydratase
Thermobispora bispora	14880	Tbis_2872	GDP-mannose 4,6-dehydratase
Thermodesulfovibrio yellowstonii		THEYE_A0469	GDP-mannose 4,6-dehydratase
Thermomicrobium roseum		trd_A0915	GDP-mannose 4,6-dehydratase
Thermomonospora curvata	15933	Tcur_2622	GDP-mannose 4,6-dehydratase
Tsukamurella paurometabola	16120	Tpau_2614	GDP-mannose 4,6-dehydratase
Xenococcus sp.		Xen7305DRAFT_00003290	GDP-mannose 4,6-dehydratase
		Xen7305DRAFT_00042140	GDP-D-mannose dehydratase
		Xen7305DRAFT_00045920	GDP-mannose 4,6-dehydratase
Yersinia bercovieri	105717	yberc0001_16670	GDP-mannose 4,6-dehydratase
Yersinia rohdei	105715	yrohd0001_37320	GDP-mannose 4,6-dehydratase
Zymomonas mobilis subsp. pomaceae	13757	Zymop_1691	GDP-mannose 4,6-dehydratase