BLAST table : Grana_00080

	accession	DB	alignment	Evalue	Score	Ident.	link	product	gene	organism	ec
1	Q9ZA43_STRVN (Q9ZA43)			0.0	766	100%	UniProt GenBank	Putative glycosyl transferase	gra-orf14	Streptomyces violaceoruber
2	E3T492_9ACTO (E3T492)			0.0	723	95%	UniProt GenBank	Putative glycosyl transferase	gra-orf14	Streptomyces vietnamensis
3	Q56176_STRVN (Q56176)			1e-168	597	99%	UniProt GenBank	ORF5; putative		Streptomyces violaceoruber
4	Q2HR56_9ACTO (Q2HR56)			9e-93	345	48%	UniProt GenBank	Putative C-glycosyltransferase	schS7	Streptomyces sp. SCC 2136
5	C4NYL6_9ACTO (C4NYL6)			7e-91	338	49%	UniProt GenBank	SaqGT5	saqGT5	Micromonospora sp. Tu 6368
6	D9UBQ7_STRPR (D9UBQ7)			4e-89	333	49%	UniProt GenBank	Putative glycosyltransferase	cpp27	Streptomyces pristinaespiralis	2.4.1.- niceE keggE
7	B5HIT9_STRPR (B5HIT9)			4e-89	333	49%	UniProt GenBank	Predicted protein	SSDG_05076	Streptomyces pristinaespiralis ATCC 25486
8	D6AXP3_9ACTO (D6AXP3)			1e-84	318	46%	UniProt GenBank	C-glycosyltransferase SaqGT5	SSHG_05335	Streptomyces albus J1074
9	Q9ZGC0_STRCY (Q9ZGC0)			1e-81	308	45%	UniProt GenBank	Glycosyl transferase homolog	lanGT2	Streptomyces cyanogenus
10	Q7WT14_9ACTO (Q7WT14)			6e-80	302	46%	UniProt GenBank	C-glycosyl transferase	med-ORF8	Streptomyces sp. AM-7161
11	A8M6E3_SALAI (A8M6E3)			7e-77	292	43%	UniProt GenBank	Putative uncharacterized protein	Sare_1263	Salinispora arenicola (strain CNS-205)
12	Q67G44_9ACTO (Q67G44)			3e-75	287	46%	UniProt GenBank	Glycosyltransferase		Streptomyces griseoruber
13	Q9RPA7_STRFR (Q9RPA7)			2e-74	284	43%	UniProt GenBank	Glycosyl transferase	urdGT2	Streptomyces fradiae Streptomyces roseoflavus
14	D1A6R8_THECD (D1A6R8)			3e-74	283	42%	UniProt GenBank	Putative uncharacterized protein	Tcur_2776	Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
15	D8HZA4_AMYMU (D8HZA4)			3e-69	267	39%	UniProt GenBank	DNTP-hexose glycosyl transferase	AMED_0639	Amycolatopsis mediterranei (strain U-32)
16	O52563_AMYMD (O52563)			3e-69	267	39%	UniProt GenBank	Putative dNTP-hexose glycosyltransferase		Amycolatopsis mediterranei Nocardia mediterranei
17	D1H0I8_9ACTO (D1H0I8)			5e-68	263	40%	UniProt GenBank	Putative C-glycosyltransferase	ravGT	Streptomyces sp. C23201NS3
18	C4RPA0_9ACTO (C4RPA0)			2e-65	254	40%	UniProt GenBank	C-glycosyl transferase	MCAG_03663	Micromonospora sp. ATCC 39149
19	D1H0B4_9ACTO (D1H0B4)			1e-64	251	40%	UniProt GenBank	Putative C-glycosyltransferase	chryGT	Streptomyces albaduncus
20	A4X714_SALTO (A4X714)			7e-60	236	38%	UniProt GenBank	Putative uncharacterized protein	Strop_2213	Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
21	D1A6T1_THECD (D1A6T1)			5e-59	233	40%	UniProt GenBank	Putative uncharacterized protein	Tcur_2790	Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
22	D6MSX4_9ACTO (D6MSX4)			2e-55	221	35%	UniProt GenBank	SsfS6	ssfS6	Streptomyces sp. SF2575
23	A4X721_SALTO (A4X721)			4e-51	206	37%	UniProt GenBank	Putative uncharacterized protein	Strop_2220	Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
24	F3P8A7_9ACTO (F3P8A7)			4e-51	206	33%	UniProt GenBank	Putative uncharacterized protein	HMPREF9056_01277	Actinomyces sp. oral taxon 170 str. F0386
25	Q67G38_9ACTO (Q67G38)			1e-48	198	37%	UniProt GenBank	Glycosyltransferase		Streptomyces griseoruber
26	Q4R0L9_STRCX (Q4R0L9)			1e-45	188	36%	UniProt GenBank	ChaGT1 protein	chaGT1	Streptomyces chartreusis
27	Q6QWC4_STRGL (Q6QWC4)			1e-44	185	49%	UniProt GenBank	Glycosyltransferase lndGT2		Streptomyces globisporus
28	Q70J67_STRGR (Q70J67)			3e-44	184	36%	UniProt GenBank	Glycosyltransferase	cmmGII	Streptomyces griseus subsp. griseus
29	Q7X2H0_9ACTO (Q7X2H0)			1e-42	179	33%	UniProt GenBank	Putative C-glycosyltransferase	gilGT	Streptomyces griseoflavus
30	E3IZG9_FRASU (E3IZG9)			7e-41	172	34%	UniProt GenBank	Putative uncharacterized protein	FraEuI1c_4748	Frankia sp. (strain EuI1c)
31	Q8GHC2_9ACTO (Q8GHC2)			2e-40	171	34%	UniProt GenBank	Glycosyltransferase	cloM	Streptomyces roseochromogenes subsp. oscitans
32	A8Y8I2_STRAM (A8Y8I2)			4e-40	170	35%	UniProt GenBank	Putative glycosyltransferase	srm18	Streptomyces ambofaciens
33	D8I4K4_AMYMU (D8I4K4)			3e-38	164	30%	UniProt GenBank	Putative glycosyl transferase	AMED_5418	Amycolatopsis mediterranei (strain U-32)
34	D8I4K0_AMYMU (D8I4K0)			6e-38	163	32%	UniProt GenBank	Putative glycosyl transferase	AMED_5414	Amycolatopsis mediterranei (strain U-32)
35	Q9ZGB8_STRCY (Q9ZGB8)			8e-38	162	32%	UniProt GenBank	Glycosyl transferase homolog	lanGT1	Streptomyces cyanogenus
36	Q9L9F5_STRSH (Q9L9F5)			2e-37	160	32%	UniProt GenBank	NovM	novM	Streptomyces spheroides Streptomyces caeruleus
37	A4FK43_SACEN (A4FK43)			5e-37	159	32%	UniProt GenBank	Putative glycosyl transferase, related to UDP-glucuronosyltransferase	iroB SACE_5174	Saccharopolyspora erythraea (strain NRRL 23338)
38	E5RLN7_9ACTO (E5RLN7)			3e-36	157	32%	UniProt GenBank	Putative glycosyltransferase	pnxGT2	Streptomyces sp. TA-0256
39	D8I4I4_AMYMU (D8I4I4)			3e-35	154	32%	UniProt GenBank	Putative glycosyl transferase	AMED_5398	Amycolatopsis mediterranei (strain U-32)
40	Q2HR28_9ACTO (Q2HR28)			7e-35	152	30%	UniProt GenBank	Putative O-glycosyltransferase	schS9	Streptomyces sp. SCC 2136
41	Q70J68_STRGR (Q70J68)			1e-34	151	32%	UniProt GenBank	Glycosyltransferase	cmmGIV	Streptomyces griseus subsp. griseus
42	Q9F8U7_9ACTO (Q9F8U7)			6e-34	149	31%	UniProt GenBank	Glycosyl transferase	couM	Streptomyces rishiriensis
43	D7BZS3_STRBB (D7BZS3)			7e-33	146	31%	UniProt GenBank	Glycosyl transferase, NDP-D-desosamine: 3-L-mycarosyl erythronolide B	SBI_06858	Streptomyces bingchenggensis (strain BCW-1)
44	A4GV85_9ACTO (A4GV85)			8e-33	145	31%	UniProt GenBank	Glycosyltransferase	holC	Streptomyces rufochromogenes
45	Q70J80_STRGR (Q70J80)			8e-33	145	32%	UniProt GenBank	Glycosyltransferase	cmmGI	Streptomyces griseus subsp. griseus
46	Q194P9_STRAA (Q194P9)			2e-32	144	32%	UniProt GenBank	Glycosyltransferase	mtmGIII	Streptomyces argillaceus
47	A4GV88_9ACTO (A4GV88)			4e-32	143	30%	UniProt GenBank	Glycosyltransferase	holL	Streptomyces sp. Tu1156
48	C4NYL0_9ACTO (C4NYL0)			4e-31	140	31%	UniProt GenBank	SaqGT3	saqGT3	Micromonospora sp. Tu 6368
49	C4NCL8_9ACTO (C4NCL8)			5e-31	140	30%	UniProt GenBank	Rhamnosyltransferase	cpz31	Streptomyces sp. MK730-62F2
50	B3TMP5_9ACTO (B3TMP5)			6e-31	139	31%	UniProt GenBank	Glycosyltransferase	KijC1	Actinomadura kijaniata
51	C4NYL1_9ACTO (C4NYL1)			9e-31	139	32%	UniProt GenBank	SaqGT4	saqGT4	Micromonospora sp. Tu 6368
52	D1GLU2_9ACTO (D1GLU2)			1e-30	139	30%	UniProt GenBank	Glycosyltransferase	slgG	Streptomyces lydicus
53	Q194Q0_STRAA (Q194Q0)			1e-30	139	32%	UniProt GenBank	Glycosyltransferase	mtmGIV	Streptomyces argillaceus
54	Q76KZ6_STRHA (Q76KZ6)			2e-30	137	29%	UniProt GenBank	Glycosyltransferase	vinC	Streptomyces halstedii
55	B3TMR7_9ACTO (B3TMR7)			3e-30	137	33%	UniProt GenBank	Glycosyltransferase	KijD9	Actinomadura kijaniata
56	Q70J70_STRGR (Q70J70)			1e-29	135	31%	UniProt GenBank	Glycosyltransferase	cmmGIII	Streptomyces griseus subsp. griseus
57	A4GV89_9ACTO (A4GV89)			3e-29	134	28%	UniProt GenBank	Glycosyltransferase	holN	Streptomyces sp. FU107
58	D7BZR5_STRBB (D7BZR5)			1e-28	132	28%	UniProt GenBank	Glycosyl transferase, NDP-D-desosamine: 3-L-mycarosyl erythronolide B	SBI_06850	Streptomyces bingchenggensis (strain BCW-1)
59	C0JWA3_9ACTO (C0JWA3)			2e-28	131	31%	UniProt GenBank	PokGT1	pokGT1	Streptomyces diastatochromogenes
60	D9V5B8_9ACTO (D9V5B8)			2e-28	131	31%	UniProt GenBank	Putative uncharacterized protein	SSMG_00597	Streptomyces sp. AA4
61	Q9RPA1_STRFR (Q9RPA1)			2e-28	131	31%	UniProt GenBank	Glycosyl transferase	urdGT1b	Streptomyces fradiae Streptomyces roseoflavus
62	D9V2R2_9ACTO (D9V2R2)			3e-28	130	30%	UniProt GenBank	Putative uncharacterized protein	SSMG_02628	Streptomyces sp. AA4
63	Q194P6_STRAA (Q194P6)			4e-28	130	30%	UniProt GenBank	Glycosyltransferase	mtmGII	Streptomyces argillaceus
64	A4F7H2_SACEN (A4F7H2)			5e-28	130	29%	UniProt GenBank	Putative glucosyltransferase	iroB SACE_0652	Saccharopolyspora erythraea (strain NRRL 23338)	2.4.1.- niceE keggE
65	D9VC49_9ACTO (D9VC49)			7e-28	129	30%	UniProt GenBank	Predicted protein	SSMG_03437	Streptomyces sp. AA4
66	D9UBS0_STRPR (D9UBS0)			7e-28	129	29%	UniProt GenBank	Putative glycosyltransferase	cpp14	Streptomyces pristinaespiralis	2.4.1.- niceE keggE
67	B5HIV2_STRPR (B5HIV2)			7e-28	129	29%	UniProt GenBank	Putative uncharacterized protein	SSDG_05089	Streptomyces pristinaespiralis ATCC 25486
68	Q194P5_STRAA (Q194P5)			9e-28	129	31%	UniProt GenBank	Glycosyltransferase	mtmGI	Streptomyces argillaceus
69	F5XMX3_9ACTO (F5XMX3)			1e-27	128	30%	UniProt GenBank	Putative glycosyltransferase	MLP_10320	Microlunatus phosphovorus NM-1	2.4.-.- niceE keggE
70	Q0R4N0_STRAT (Q0R4N0)			2e-27	128	29%	UniProt GenBank	ChlC6		Streptomyces antibioticus
71	Q9ALN7_9PSEU (Q9ALN7)			4e-27	127	28%	UniProt GenBank	Probable NDP-forosamyltransferase	spnP	Saccharopolyspora spinosa
72	B3TMP7_9ACTO (B3TMP7)			4e-27	127	29%	UniProt GenBank	Glycosyltransferase	KijC3	Actinomadura kijaniata
73	Q52V43_9ACTO (Q52V43)			5e-27	126	31%	UniProt GenBank	Glycosyltransferase		Streptomyces aizunensis
74	Q9RP99_STRFR (Q9RP99)			6e-27	126	30%	UniProt GenBank	Glycosyl transferase	urdGT1c	Streptomyces fradiae Streptomyces roseoflavus
75	D8I4J6_AMYMU (D8I4J6)			8e-27	125	31%	UniProt GenBank	Putative glycosyl transferase	AMED_5410	Amycolatopsis mediterranei (strain U-32)
76	A4FB95_SACEN (A4FB95)			2e-26	125	31%	UniProt GenBank	Putative glycosyltransferase	SACE_2010	Saccharopolyspora erythraea (strain NRRL 23338)
77	B5L6L8_MICCH (B5L6L8)			2e-26	124	28%	UniProt GenBank	Glycosyltransferase		Micromonospora chalcea
78	B5L6J8_MICCH (B5L6J8)			2e-26	124	30%	UniProt GenBank	Glycosyltransferase		Micromonospora chalcea
79	Q0H2X6_9ACTO (Q0H2X6)			3e-26	124	29%	UniProt GenBank	Putative O-glycosyltransferase	atG1	Actinomadura melliaura
80	P95834_STRPE (P95834)			4e-26	124	30%	UniProt GenBank	Putative baumycin biosynthesis protein	dnrH	Streptomyces peucetius
81	Q4JHR2_9PSEU (Q4JHR2)			5e-26	123	30%	UniProt GenBank	BusG	busG	Saccharopolyspora pogona
82	D4QF41_9ACTO (D4QF41)			5e-26	123	27%	UniProt GenBank	Rhamnosyltransferase	lipB1	Streptomyces sp. SANK 60405
83	Q9ALM8_9PSEU (Q9ALM8)			7e-26	122	30%	UniProt GenBank	Probable NDP-rhamnosyltransferase	spnG	Saccharopolyspora spinosa
84	Q6T1C7_STRGL (Q6T1C7)			8e-26	122	29%	UniProt GenBank	Glycosyltransferase LndGT4		Streptomyces globisporus
85	Q6QR18_STRGL (Q6QR18)			1e-25	122	30%	UniProt GenBank	Glycosyl transferase		Streptomyces globisporus
86	C0JWA0_9ACTO (C0JWA0)			1e-25	122	30%	UniProt GenBank	PokGT2	pokGT2	Streptomyces diastatochromogenes
87	A4F7P3_SACEN (A4F7P3)			1e-25	122	28%	UniProt GenBank	Glycosyl transferase, NDP-D-desosamine : 3-L-mycarosyl erythronolide B	eryCIII SACE_0726	Saccharopolyspora erythraea (strain NRRL 23338)
88	O54224_SACER (O54224)			1e-25	122	28%	UniProt GenBank	Glycosyltransferase	eryCIII	Saccharopolyspora erythraea Streptomyces erythraeus
89	D7B014_NOCDD (D7B014)			2e-25	121	28%	UniProt GenBank	Putative uncharacterized protein	Ndas_4716	Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488) Actinomadura dassonvillei
90	D2AY79_STRRD (D2AY79)			2e-25	121	32%	UniProt GenBank	IroB	Sros_4185	Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
91	D9UBQ5_STRPR (D9UBQ5)			4e-25	120	29%	UniProt GenBank	Putative glycosyltransferase	cpp29	Streptomyces pristinaespiralis	2.4.1.- niceE keggE
92	D6X7X2_STRPR (D6X7X2)			4e-25	120	29%	UniProt GenBank	Glycosyltransferase LndGT4	SSDG_07505	Streptomyces pristinaespiralis ATCC 25486
93	Q4JHQ3_9PSEU (Q4JHQ3)			5e-25	120	28%	UniProt GenBank	BusP	busP	Saccharopolyspora pogona
94	O33935_SACER (O33935)			9e-25	119	27%	UniProt GenBank	Desosaminyltransferase	eryCIII	Saccharopolyspora erythraea Streptomyces erythraeus
95	Q8KNF2_MICEC (Q8KNF2)			9e-25	119	31%	UniProt GenBank	CalG1	calG1	Micromonospora echinospora Micromonospora purpurea
96	A4GV86_9ACTO (A4GV86)			1e-24	119	28%	UniProt GenBank	Glycosyltransferase	holA	Streptomyces sp. FU107
97	B3TMN6_9ACTO (B3TMN6)			1e-24	119	28%	UniProt GenBank	Glycosyltransferase	KijA4	Actinomadura kijaniata
98	B7T1A8_9BACT (B7T1A8)			1e-24	118	28%	UniProt GenBank	Veg36	veg36	uncultured soil bacterium
99	B5L6L9_MICCH (B5L6L9)			1e-24	118	31%	UniProt GenBank	Glycosyltransferase		Micromonospora chalcea
100	D7BZS5_STRBB (D7BZS5)			2e-24	118	28%	UniProt GenBank	IroB	SBI_06860	Streptomyces bingchenggensis (strain BCW-1)

	accession	DB	alignment	Evalue	Score	Ident.	link	information	pubmed
1	Q9ZA43_STRVN (Q9ZA43)			0.0	766	100%	UniProt GenBank	Product Putative glycosyl transferase Gene gra-orf14 Organism Streptomyces violaceoruber	1uniprot[Pubmed] 2583128 [Medline] 90060034 Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber Tu22.(EMBO J.) [1989] 2uniprot[Pubmed] 7476861 [Medline] 96027933 Identification of Streptomyces violaceoruber Tu22 genes involved in the biosynthesis of granaticin.(Mol. Gen. Genet.) [1995] 3uniprot[Pubmed] 9831526 [Medline] 99051446 The granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tu22: sequence analysis and expression in a heterologous host.(Chem. Biol.) [1998] [pubmed all]
3	Q56176_STRVN (Q56176)			1e-168	597	99%	UniProt GenBank	Product ORF5; putative Gene   Organism Streptomyces violaceoruber	1uniprot[Pubmed] 7476861 [Medline] 96027933 Identification of Streptomyces violaceoruber Tu22 genes involved in the biosynthesis of granaticin.(Mol. Gen. Genet.) [1995]
4	Q2HR56_9ACTO (Q2HR56)			9e-93	345	48%	UniProt GenBank	Product Putative C-glycosyltransferase Gene schS7 Organism Streptomyces sp. SCC 2136	1uniprot Angucyclines Sch 47554 and Sch 47555 from Streptomyces sp. SCC-2136: Cloning, Sequencing, and Characterization.(Mol. Cells) [2006] 2uniprot Molecular cloning and characterization of biosynthetic genes cluster of Sch 47554 from Streptomyces sp. SCC 2136. [2004]
5	C4NYL6_9ACTO (C4NYL6)			7e-91	338	49%	UniProt GenBank	Product SaqGT5 Gene saqGT5 Organism Micromonospora sp. Tu 6368	1uniprot[Pubmed] 17497146 A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007] 2uniprot[Pubmed] 19384899 Cloning and sequencing of the biosynthetic gene cluster for saquayamycin z and galtamycin B and the elucidation of the assembly of their saccharide chains.(Chembiochem) [2009] [pubmed all]
6	D9UBQ7_STRPR (D9UBQ7)			4e-89	333	49%	UniProt GenBank	Product Putative glycosyltransferase Gene cpp27 Organism Streptomyces pristinaespiralis	1uniprot[Pubmed] 21342465 Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011]
9	Q9ZGC0_STRCY (Q9ZGC0)			1e-81	308	45%	UniProt GenBank	Product Glycosyl transferase homolog Gene lanGT2 Organism Streptomyces cyanogenus	1uniprot[Pubmed] 9933932 [Medline] 99132695 Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin biosynthesis.(FEMS Microbiol. Lett.) [1999]
10	Q7WT14_9ACTO (Q7WT14)			6e-80	302	46%	UniProt GenBank	Product C-glycosyl transferase Gene med-ORF8 Organism Streptomyces sp. AM-7161	1uniprot Cloning, sequencing and heterologous expression of the medermycin biosynthetic gene cluster of Streptomyces sp. AM-7161: towards comparative analysis of the benzoisochromanequione gene clusters.(Microbiology (Mosc.)) [2003]
12	Q67G44_9ACTO (Q67G44)			3e-75	287	46%	UniProt GenBank	Product Glycosyltransferase Gene   Organism Streptomyces griseoruber	1uniprot[Pubmed] 15271354 The hedamycin locus implicates a novel aromatic PKS priming mechanism.(Chem. Biol.) [2004]
13	Q9RPA7_STRFR (Q9RPA7)			2e-74	284	43%	UniProt GenBank	Product Glycosyl transferase Gene urdGT2 Organism Streptomyces fradiae Streptomyces roseoflavus	1uniprot[Pubmed] 10658661 [Medline] 20121748 Two new tailoring enzymes, a glycosyltransferase and an oxygenase, involved in biosynthesis of the angucycline antibiotic urdamycin A in Streptomyces fradiae Tu2717.(Microbiology) [2000] 2uniprot[Pubmed] 17640665 Structure and action of the C-C bond-forming glycosyltransferase UrdGT2 involved in the biosynthesis of the antibiotic urdamycin.(J. Mol. Biol.) [2007] [pubmed all]
14	D1A6R8_THECD (D1A6R8)			3e-74	283	42%	UniProt GenBank	Product Putative uncharacterized protein Gene Tcur_2776 Organism Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)	1uniprot Complete genome sequence of Thermomonospora curvata type strain (B9).(Stand. Genomic Sci.) [2011]
15	D8HZA4_AMYMU (D8HZA4)			3e-69	267	39%	UniProt GenBank	Product DNTP-hexose glycosyl transferase Gene AMED_0639 Organism Amycolatopsis mediterranei (strain U-32)	1uniprot[Pubmed] 20567260 Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]
16	O52563_AMYMD (O52563)			3e-69	267	39%	UniProt GenBank	Product Putative dNTP-hexose glycosyltransferase Gene   Organism Amycolatopsis mediterranei Nocardia mediterranei	1uniprot[Pubmed] 9512878 [Medline] 98174059 Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699.(Chem. Biol.) [1998] 2uniprot[Pubmed] 9497318 [Medline] 98165773 3-amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the formation of the precursor of mC7N units in rifamycin and related antibiotics.(J. Biol. Chem.) [1998] 3uniprot[Pubmed] 11278540 [Medline] 21201076 Mutational analysis and reconstituted expression of the biosynthetic genes involved in the formation of 3-amino-5-hydroxybenzoic acid, the starter unit of rifamycin biosynthesis in amycolatopsis Mediterranei S699.(J. Biol. Chem.) [2001] [pubmed all]
21	D1A6T1_THECD (D1A6T1)			5e-59	233	40%	UniProt GenBank	Product Putative uncharacterized protein Gene Tcur_2790 Organism Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)	1uniprot Complete genome sequence of Thermomonospora curvata type strain (B9).(Stand. Genomic Sci.) [2011]
22	D6MSX4_9ACTO (D6MSX4)			2e-55	221	35%	UniProt GenBank	Product SsfS6 Gene ssfS6 Organism Streptomyces sp. SF2575	1uniprot[Pubmed] 19908837 Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.(J. Am. Chem. Soc.) [2009]
25	Q67G38_9ACTO (Q67G38)			1e-48	198	37%	UniProt GenBank	Product Glycosyltransferase Gene   Organism Streptomyces griseoruber	1uniprot[Pubmed] 15271354 The hedamycin locus implicates a novel aromatic PKS priming mechanism.(Chem. Biol.) [2004]
26	Q4R0L9_STRCX (Q4R0L9)			1e-45	188	36%	UniProt GenBank	Product ChaGT1 protein Gene chaGT1 Organism Streptomyces chartreusis	1uniprot[Pubmed] 15911378 Biosynthesis of the antitumor agent chartreusin involves the oxidative rearrangement of an anthracyclic polyketide.(Chem. Biol.) [2005]
27	Q6QWC4_STRGL (Q6QWC4)			1e-44	185	49%	UniProt GenBank	Product Glycosyltransferase lndGT2 Gene   Organism Streptomyces globisporus	1uniprot[Pubmed] 15123249 Generation of new landomycins by combinatorial biosynthetic manipulation of the LndGT4 gene of the landomycin E cluster in S. globisporus.(Chem. Biol.) [2004]
29	Q7X2H0_9ACTO (Q7X2H0)			1e-42	179	33%	UniProt GenBank	Product Putative C-glycosyltransferase Gene gilGT Organism Streptomyces griseoflavus	1uniprot[Pubmed] 12822997 [Medline] 22708304 The complete gene cluster of the antitumor agent gilvocarcin V and its implication for the biosynthesis of the gilvocarcins.(J. Am. Chem. Soc.) [2003]
31	Q8GHC2_9ACTO (Q8GHC2)			2e-40	171	34%	UniProt GenBank	Product Glycosyltransferase Gene cloM Organism Streptomyces roseochromogenes subsp. oscitans	1uniprot[Pubmed] 12480894 [Medline] 22368916 Molecular cloning and sequence analysis of the clorobiocin biosynthetic gene cluster: new insights into the biosynthesis of aminocoumarin antibiotics.(Microbiology) [2002]
32	A8Y8I2_STRAM (A8Y8I2)			4e-40	170	35%	UniProt GenBank	Product Putative glycosyltransferase Gene srm18 Organism Streptomyces ambofaciens	1uniprot Organization of the biosynthetic gene cluster for the macrolide antibiotic spiramycin in Streptomyces ambofaciens.(Microbiology (Mosc.)) [2007]
33	D8I4K4_AMYMU (D8I4K4)			3e-38	164	30%	UniProt GenBank	Product Putative glycosyl transferase Gene AMED_5418 Organism Amycolatopsis mediterranei (strain U-32)	1uniprot[Pubmed] 20567260 Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]
34	D8I4K0_AMYMU (D8I4K0)			6e-38	163	32%	UniProt GenBank	Product Putative glycosyl transferase Gene AMED_5414 Organism Amycolatopsis mediterranei (strain U-32)	1uniprot[Pubmed] 20567260 Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]
35	Q9ZGB8_STRCY (Q9ZGB8)			8e-38	162	32%	UniProt GenBank	Product Glycosyl transferase homolog Gene lanGT1 Organism Streptomyces cyanogenus	1uniprot[Pubmed] 9933932 [Medline] 99132695 Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin biosynthesis.(FEMS Microbiol. Lett.) [1999]
36	Q9L9F5_STRSH (Q9L9F5)			2e-37	160	32%	UniProt GenBank	Product NovM Gene novM Organism Streptomyces spheroides Streptomyces caeruleus	1uniprot[Pubmed] 10770754 [Medline] 20233587 Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891.(Antimicrob. Agents Chemother.) [2000]
37	A4FK43_SACEN (A4FK43)			5e-37	159	32%	UniProt GenBank	Product Putative glycosyl transferase, related to UDP-glucuronosyltransferase Gene iroB SACE_5174 Organism Saccharopolyspora erythraea (strain NRRL 23338)	1uniprot[Pubmed] 17369815 Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007]
39	D8I4I4_AMYMU (D8I4I4)			3e-35	154	32%	UniProt GenBank	Product Putative glycosyl transferase Gene AMED_5398 Organism Amycolatopsis mediterranei (strain U-32)	1uniprot[Pubmed] 20567260 Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]
40	Q2HR28_9ACTO (Q2HR28)			7e-35	152	30%	UniProt GenBank	Product Putative O-glycosyltransferase Gene schS9 Organism Streptomyces sp. SCC 2136	1uniprot Angucyclines Sch 47554 and Sch 47555 from Streptomyces sp. SCC-2136: Cloning, Sequencing, and Characterization.(Mol. Cells) [2006] 2uniprot Molecular cloning and characterization of biosynthetic genes cluster of Sch 47554 from Streptomyces sp. SCC 2136. [2004]
42	Q9F8U7_9ACTO (Q9F8U7)			6e-34	149	31%	UniProt GenBank	Product Glycosyl transferase Gene couM Organism Streptomyces rishiriensis	1uniprot[Pubmed] 11036020 [Medline] 20493109 Identification of the coumermycin A(1) biosynthetic gene cluster of Streptomyces rishiriensis DSM 40489.(Antimicrob. Agents Chemother.) [2000]
43	D7BZS3_STRBB (D7BZS3)			7e-33	146	31%	UniProt GenBank	Product Glycosyl transferase, NDP-D-desosamine: 3-L-mycarosyl erythronolide B Gene SBI_06858 Organism Streptomyces bingchenggensis (strain BCW-1)	1uniprot[Pubmed] 20581206 Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]
44	A4GV85_9ACTO (A4GV85)			8e-33	145	31%	UniProt GenBank	Product Glycosyltransferase Gene holC Organism Streptomyces rufochromogenes	1uniprot[Pubmed] 17497146 A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]
46	Q194P9_STRAA (Q194P9)			2e-32	144	32%	UniProt GenBank	Product Glycosyltransferase Gene mtmGIII Organism Streptomyces argillaceus	1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996] 2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996] 3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997] 4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998] 5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999] 6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999] 7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000] 8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001] 9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003] 10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999] 11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002] 12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000] 13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000] 14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002] 15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003] 16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996] 17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004] 18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997] 19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005] 20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000] [pubmed all]
47	A4GV88_9ACTO (A4GV88)			4e-32	143	30%	UniProt GenBank	Product Glycosyltransferase Gene holL Organism Streptomyces sp. Tu1156	1uniprot[Pubmed] 17497146 A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]
48	C4NYL0_9ACTO (C4NYL0)			4e-31	140	31%	UniProt GenBank	Product SaqGT3 Gene saqGT3 Organism Micromonospora sp. Tu 6368	1uniprot[Pubmed] 17497146 A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007] 2uniprot[Pubmed] 19384899 Cloning and sequencing of the biosynthetic gene cluster for saquayamycin z and galtamycin B and the elucidation of the assembly of their saccharide chains.(Chembiochem) [2009] [pubmed all]
49	C4NCL8_9ACTO (C4NCL8)			5e-31	140	30%	UniProt GenBank	Product Rhamnosyltransferase Gene cpz31 Organism Streptomyces sp. MK730-62F2	1uniprot[Pubmed] 19351877 Identification and manipulation of the caprazamycin gene cluster leads to new simplified liponucleoside antibiotics and gives insights into the biosynthetic pathway.(J. Biol. Chem.) [2009]
50	B3TMP5_9ACTO (B3TMP5)			6e-31	139	31%	UniProt GenBank	Product Glycosyltransferase Gene KijC1 Organism Actinomadura kijaniata	1uniprot[Pubmed] 17985890 Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007]
51	C4NYL1_9ACTO (C4NYL1)			9e-31	139	32%	UniProt GenBank	Product SaqGT4 Gene saqGT4 Organism Micromonospora sp. Tu 6368	1uniprot[Pubmed] 17497146 A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007] 2uniprot[Pubmed] 19384899 Cloning and sequencing of the biosynthetic gene cluster for saquayamycin z and galtamycin B and the elucidation of the assembly of their saccharide chains.(Chembiochem) [2009] [pubmed all]
52	D1GLU2_9ACTO (D1GLU2)			1e-30	139	30%	UniProt GenBank	Product Glycosyltransferase Gene slgG Organism Streptomyces lydicus	1uniprot Deciphering biosynthesis of the RNA polymerase inhibitor streptolydigin and generation of glycosylated derivatives.(Chem. Biol.) [2009]
53	Q194Q0_STRAA (Q194Q0)			1e-30	139	32%	UniProt GenBank	Product Glycosyltransferase Gene mtmGIV Organism Streptomyces argillaceus	1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996] 2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996] 3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997] 4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998] 5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999] 6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999] 7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000] 8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001] 9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003] 10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999] 11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002] 12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000] 13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000] 14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002] 15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003] 16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996] 17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004] 18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997] 19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005] 20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000] [pubmed all]
54	Q76KZ6_STRHA (Q76KZ6)			2e-30	137	29%	UniProt GenBank	Product Glycosyltransferase Gene vinC Organism Streptomyces halstedii	1uniprot[Pubmed] 15112997 Cloning, sequencing, and functional analysis of the biosynthetic gene cluster of macrolactam antibiotic vicenistatin in Streptomyces halstedii.(Chem. Biol.) [2004]
55	B3TMR7_9ACTO (B3TMR7)			3e-30	137	33%	UniProt GenBank	Product Glycosyltransferase Gene KijD9 Organism Actinomadura kijaniata	1uniprot[Pubmed] 17985890 Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007]
57	A4GV89_9ACTO (A4GV89)			3e-29	134	28%	UniProt GenBank	Product Glycosyltransferase Gene holN Organism Streptomyces sp. FU107	1uniprot[Pubmed] 17497146 A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]
58	D7BZR5_STRBB (D7BZR5)			1e-28	132	28%	UniProt GenBank	Product Glycosyl transferase, NDP-D-desosamine: 3-L-mycarosyl erythronolide B Gene SBI_06850 Organism Streptomyces bingchenggensis (strain BCW-1)	1uniprot[Pubmed] 20581206 Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]
59	C0JWA3_9ACTO (C0JWA3)			2e-28	131	31%	UniProt GenBank	Product PokGT1 Gene pokGT1 Organism Streptomyces diastatochromogenes	1uniprot[Pubmed] 19266534 Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009]
61	Q9RPA1_STRFR (Q9RPA1)			2e-28	131	31%	UniProt GenBank	Product Glycosyl transferase Gene urdGT1b Organism Streptomyces fradiae Streptomyces roseoflavus	1uniprot[Pubmed] 10658661 [Medline] 20121748 Two new tailoring enzymes, a glycosyltransferase and an oxygenase, involved in biosynthesis of the angucycline antibiotic urdamycin A in Streptomyces fradiae Tu2717.(Microbiology) [2000]
63	Q194P6_STRAA (Q194P6)			4e-28	130	30%	UniProt GenBank	Product Glycosyltransferase Gene mtmGII Organism Streptomyces argillaceus	1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996] 2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996] 3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997] 4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998] 5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999] 6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999] 7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000] 8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001] 9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003] 10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999] 11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002] 12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000] 13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000] 14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002] 15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003] 16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996] 17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004] 18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997] 19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005] 20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000] [pubmed all]
64	A4F7H2_SACEN (A4F7H2)			5e-28	130	29%	UniProt GenBank	Product Putative glucosyltransferase Gene iroB SACE_0652 Organism Saccharopolyspora erythraea (strain NRRL 23338)	1uniprot[Pubmed] 17369815 Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007]
66	D9UBS0_STRPR (D9UBS0)			7e-28	129	29%	UniProt GenBank	Product Putative glycosyltransferase Gene cpp14 Organism Streptomyces pristinaespiralis	1uniprot[Pubmed] 21342465 Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011]
68	Q194P5_STRAA (Q194P5)			9e-28	129	31%	UniProt GenBank	Product Glycosyltransferase Gene mtmGI Organism Streptomyces argillaceus	1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996] 2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996] 3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997] 4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998] 5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999] 6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999] 7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000] 8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001] 9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003] 10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999] 11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002] 12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000] 13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000] 14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002] 15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003] 16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996] 17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004] 18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997] 19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005] 20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000] [pubmed all]
70	Q0R4N0_STRAT (Q0R4N0)			2e-27	128	29%	UniProt GenBank	Product ChlC6 Gene   Organism Streptomyces antibioticus	1uniprot[Pubmed] 16793515 Genetic characterization of the chlorothricin gene cluster as a model for spirotetronate antibiotic biosynthesis.(Chem. Biol.) [2006]
71	Q9ALN7_9PSEU (Q9ALN7)			4e-27	127	28%	UniProt GenBank	Product Probable NDP-forosamyltransferase Gene spnP Organism Saccharopolyspora spinosa	1uniprot[Pubmed] 11358695 [Medline] 21257765 Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa.(Chem. Biol.) [2001]
72	B3TMP7_9ACTO (B3TMP7)			4e-27	127	29%	UniProt GenBank	Product Glycosyltransferase Gene KijC3 Organism Actinomadura kijaniata	1uniprot[Pubmed] 17985890 Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007]
73	Q52V43_9ACTO (Q52V43)			5e-27	126	31%	UniProt GenBank	Product Glycosyltransferase Gene   Organism Streptomyces aizunensis	1uniprot[Pubmed] 15844935 Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example.(J. Nat. Prod.) [2005]
74	Q9RP99_STRFR (Q9RP99)			6e-27	126	30%	UniProt GenBank	Product Glycosyl transferase Gene urdGT1c Organism Streptomyces fradiae Streptomyces roseoflavus	1uniprot[Pubmed] 10658661 [Medline] 20121748 Two new tailoring enzymes, a glycosyltransferase and an oxygenase, involved in biosynthesis of the angucycline antibiotic urdamycin A in Streptomyces fradiae Tu2717.(Microbiology) [2000]
75	D8I4J6_AMYMU (D8I4J6)			8e-27	125	31%	UniProt GenBank	Product Putative glycosyl transferase Gene AMED_5410 Organism Amycolatopsis mediterranei (strain U-32)	1uniprot[Pubmed] 20567260 Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]
76	A4FB95_SACEN (A4FB95)			2e-26	125	31%	UniProt GenBank	Product Putative glycosyltransferase Gene SACE_2010 Organism Saccharopolyspora erythraea (strain NRRL 23338)	1uniprot[Pubmed] 17369815 Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007]
77	B5L6L8_MICCH (B5L6L8)			2e-26	124	28%	UniProt GenBank	Product Glycosyltransferase Gene   Organism Micromonospora chalcea	1uniprot[Pubmed] 18586939 Cloning and characterization of the tetrocarcin A gene cluster from Micromonospora chalcea NRRL 11289 reveals a highly conserved strategy for tetronate biosynthesis in spirotetronate antibiotics.(J. Bacteriol.) [2008]
78	B5L6J8_MICCH (B5L6J8)			2e-26	124	30%	UniProt GenBank	Product Glycosyltransferase Gene   Organism Micromonospora chalcea	1uniprot[Pubmed] 18586939 Cloning and characterization of the tetrocarcin A gene cluster from Micromonospora chalcea NRRL 11289 reveals a highly conserved strategy for tetronate biosynthesis in spirotetronate antibiotics.(J. Bacteriol.) [2008]
79	Q0H2X6_9ACTO (Q0H2X6)			3e-26	124	29%	UniProt GenBank	Product Putative O-glycosyltransferase Gene atG1 Organism Actinomadura melliaura	1uniprot[Pubmed] 16873021 Deciphering indolocarbazole and enediyne aminodideoxypentose biosynthesis through comparative genomics: insights from the AT2433 biosynthetic locus.(Chem. Biol.) [2006]
80	P95834_STRPE (P95834)			4e-26	124	30%	UniProt GenBank	Product Putative baumycin biosynthesis protein Gene dnrH Organism Streptomyces peucetius	1uniprot[Pubmed] 8955419 [Medline] 97113559 Enhanced antibiotic production by manipulation of the Streptomyces peucetius dnrH and dnmT genes involved in doxorubicin (adriamycin) biosynthesis.(J. Bacteriol.) [1996] 2uniprot[Pubmed] 9864344 [Medline] 99084971 Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene.(J. Bacteriol.) [1999] [pubmed all]
81	Q4JHR2_9PSEU (Q4JHR2)			5e-26	123	30%	UniProt GenBank	Product BusG Gene busG Organism Saccharopolyspora pogona	1uniprot[Pubmed] 16179985 Butenyl-spinosyns, a natural example of genetic engineering of antibiotic biosynthetic genes.(J. Ind. Microbiol. Biotechnol.) [2006]
82	D4QF41_9ACTO (D4QF41)			5e-26	123	27%	UniProt GenBank	Product Rhamnosyltransferase Gene lipB1 Organism Streptomyces sp. SANK 60405	1uniprot[Pubmed] 20043306 The biosynthesis of liposidomycin-like A-90289 antibiotics featuring a new type of sulfotransferase.(Chembiochem) [2010]
83	Q9ALM8_9PSEU (Q9ALM8)			7e-26	122	30%	UniProt GenBank	Product Probable NDP-rhamnosyltransferase Gene spnG Organism Saccharopolyspora spinosa	1uniprot[Pubmed] 11358695 [Medline] 21257765 Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa.(Chem. Biol.) [2001]
84	Q6T1C7_STRGL (Q6T1C7)			8e-26	122	29%	UniProt GenBank	Product Glycosyltransferase LndGT4 Gene   Organism Streptomyces globisporus	1uniprot[Pubmed] 15123249 Generation of new landomycins by combinatorial biosynthetic manipulation of the LndGT4 gene of the landomycin E cluster in S. globisporus.(Chem. Biol.) [2004]
85	Q6QR18_STRGL (Q6QR18)			1e-25	122	30%	UniProt GenBank	Product Glycosyl transferase Gene   Organism Streptomyces globisporus	1uniprot[Pubmed] 15123249 Generation of new landomycins by combinatorial biosynthetic manipulation of the LndGT4 gene of the landomycin E cluster in S. globisporus.(Chem. Biol.) [2004]
86	C0JWA0_9ACTO (C0JWA0)			1e-25	122	30%	UniProt GenBank	Product PokGT2 Gene pokGT2 Organism Streptomyces diastatochromogenes	1uniprot[Pubmed] 19266534 Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009]
87	A4F7P3_SACEN (A4F7P3)			1e-25	122	28%	UniProt GenBank	Product Glycosyl transferase, NDP-D-desosamine : 3-L-mycarosyl erythronolide B Gene eryCIII SACE_0726 Organism Saccharopolyspora erythraea (strain NRRL 23338)	1uniprot[Pubmed] 17369815 Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007]
89	D7B014_NOCDD (D7B014)			2e-25	121	28%	UniProt GenBank	Product Putative uncharacterized protein Gene Ndas_4716 Organism Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488) Actinomadura dassonvillei	1uniprot Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010]
90	D2AY79_STRRD (D2AY79)			2e-25	121	32%	UniProt GenBank	Product IroB Gene Sros_4185 Organism Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)	1uniprot Complete genome sequence of Streptosporangium roseum type strain (NI 9100T).(Stand. Genomic Sci.) [2010]
91	D9UBQ5_STRPR (D9UBQ5)			4e-25	120	29%	UniProt GenBank	Product Putative glycosyltransferase Gene cpp29 Organism Streptomyces pristinaespiralis	1uniprot[Pubmed] 21342465 Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011]
93	Q4JHQ3_9PSEU (Q4JHQ3)			5e-25	120	28%	UniProt GenBank	Product BusP Gene busP Organism Saccharopolyspora pogona	1uniprot[Pubmed] 16179985 Butenyl-spinosyns, a natural example of genetic engineering of antibiotic biosynthetic genes.(J. Ind. Microbiol. Biotechnol.) [2006]
94	O33935_SACER (O33935)			9e-25	119	27%	UniProt GenBank	Product Desosaminyltransferase Gene eryCIII Organism Saccharopolyspora erythraea Streptomyces erythraeus	1uniprot[Pubmed] 9353926 [Medline] 98015410 Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production.(Microbiology)
95	Q8KNF2_MICEC (Q8KNF2)			9e-25	119	31%	UniProt GenBank	Product CalG1 Gene calG1 Organism Micromonospora echinospora Micromonospora purpurea	1uniprot[Pubmed] 12183629 [Medline] 22171414 The calicheamicin gene cluster and its iterative type I enediyne PKS.(Science) [2002]
96	A4GV86_9ACTO (A4GV86)			1e-24	119	28%	UniProt GenBank	Product Glycosyltransferase Gene holA Organism Streptomyces sp. FU107	1uniprot[Pubmed] 17497146 A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]
97	B3TMN6_9ACTO (B3TMN6)			1e-24	119	28%	UniProt GenBank	Product Glycosyltransferase Gene KijA4 Organism Actinomadura kijaniata	1uniprot[Pubmed] 17985890 Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007]
98	B7T1A8_9BACT (B7T1A8)			1e-24	118	28%	UniProt GenBank	Product Veg36 Gene veg36 Organism uncultured soil bacterium	1uniprot[Pubmed] 18987322 Cloning and characterization of new glycopeptide gene clusters found in an environmental DNA megalibrary.(Proc. Natl. Acad. Sci. U.S.A.) [2008]
99	B5L6L9_MICCH (B5L6L9)			1e-24	118	31%	UniProt GenBank	Product Glycosyltransferase Gene   Organism Micromonospora chalcea	1uniprot[Pubmed] 18586939 Cloning and characterization of the tetrocarcin A gene cluster from Micromonospora chalcea NRRL 11289 reveals a highly conserved strategy for tetronate biosynthesis in spirotetronate antibiotics.(J. Bacteriol.) [2008]
100	D7BZS5_STRBB (D7BZS5)			2e-24	118	28%	UniProt GenBank	Product IroB Gene SBI_06860 Organism Streptomyces bingchenggensis (strain BCW-1)	1uniprot[Pubmed] 20581206 Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]