Acid resistance (by GABA antiporter)(NFUNC_0071) |
| 必須 | A | GAD (NRULE_0231) | Glutamate decarboxylase | GOSPT_091_00050 |
|---|
GADC (NRULE_0234) | Glutamate/gamma-aminobutyrate antiporter | |
Alanine racemization(NFUNC_0063) |
| 必須 | A | ALR (NRULE_0228) | Alanine racemase | GOSPT_115_01000 |
|---|
n-alkane hydroxylation(NFUNC_0008) |
| 必須 | A | CYP153 (NRULE_0041) | Cytochrome P450 CYP153 | |
|---|
| B | ALKB (NRULE_0024) | Alkane 1-monooxygenase | GOSPT_119_00610 |
| C | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | GOSPT_087_00030 GOSPT_087_00010 |
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | GOSPT_087_00030 GOSPT_087_00010 |
FDR1 (NRULE_0032) | Oxygenase electron transfer component | GOSPT_117_00460 GOSPT_006_00540 GOSPT_042_00240 GOSPT_051_00380 GOSPT_054_00130 GOSPT_069_00110 GOSPT_087_00020 GOSPT_089_00190 GOSPT_096_00110 GOSPT_109_00150 GOSPT_141_00310 |
MME (NRULE_0033) | Multicomponent monooxygenase effector protein | GOSPT_087_00050 |
| 任意 | | RUBA (NRULE_0039) | Rubredoxin | GOSPT_119_00610 |
|---|
| | RUBB (NRULE_0040) | Rubredoxin reductase | |
| | MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
| | MMG2 (NRULE_0030) | Multicomponent monooxygenase gamma subunit | |
| | MMG3 (NRULE_0031) | Multicomponent monooxygenase gamma subunit | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | GOSPT_044_00070 GOSPT_152_00300 GOSPT_141_00330 GOSPT_109_00160 GOSPT_065_00780 GOSPT_058_00080 GOSPT_045_00330 GOSPT_045_00100 |
Aniline degradation (conversion into catechol)(NFUNC_0075) |
| 必須 | A | ATDA1 (NRULE_0240) | Gamma-glutamylanilide synthetase | GOSPT_044_00060 |
|---|
ATDA3 (NRULE_0357) | Aniline dioxygenase large subunit | |
ATDA4 (NRULE_0358) | Aniline dioxygenase small subunit | GOSPT_044_00080 |
| 任意 | | ATDA2 (NRULE_0241) | Putative gamma-glutamylanilide hydrolase | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | GOSPT_141_00310 GOSPT_006_00540 GOSPT_042_00240 GOSPT_051_00380 GOSPT_054_00130 GOSPT_069_00110 GOSPT_087_00020 GOSPT_089_00190 GOSPT_096_00110 GOSPT_109_00150 GOSPT_117_00460 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | GOSPT_109_00160 GOSPT_152_00300 GOSPT_141_00330 GOSPT_065_00780 GOSPT_058_00080 GOSPT_045_00330 GOSPT_045_00100 GOSPT_044_00070 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | GOSPT_025_00720 GOSPT_096_00080 |
Anthranilate biosynthesis(NFUNC_0038) |
| 必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | GOSPT_062_00180 |
|---|
TRPE (NRULE_0143) | Anthranilate synthase component I | GOSPT_124_00210 |
Anthranilate degradation (via hydroxylation)(NFUNC_0018) |
| 必須 | A | ANTA (NRULE_0044) | Anthranilate 1,2-dioxygenase large subunit | |
|---|
ANTB (NRULE_0045) | Anthranilate 1,2-dioxygenase small subunit | |
| 任意 | | ANTC (NRULE_0081) | Anthranilate 1,2-dioxygenase electron transfer component | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | GOSPT_096_00110 GOSPT_089_00190 GOSPT_006_00540 GOSPT_141_00310 GOSPT_042_00240 GOSPT_051_00380 GOSPT_087_00020 GOSPT_069_00110 GOSPT_117_00460 GOSPT_054_00130 GOSPT_109_00150 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | GOSPT_152_00300 GOSPT_044_00070 GOSPT_045_00100 GOSPT_045_00330 GOSPT_058_00080 GOSPT_065_00780 GOSPT_109_00160 GOSPT_141_00330 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | GOSPT_096_00080 GOSPT_025_00720 |
Aromatic hydrocarbon degradation (via hydroxylation by dioxygenase)(NFUNC_0016) |
| 必須 | A | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | GOSPT_109_00160 GOSPT_044_00070 GOSPT_141_00330 |
|---|
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | GOSPT_044_00080 GOSPT_141_00320 |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
| 任意 | | FDR1 (NRULE_0032) | Oxygenase electron transfer component | GOSPT_069_00110 GOSPT_141_00310 GOSPT_117_00460 GOSPT_109_00150 GOSPT_096_00110 GOSPT_089_00190 GOSPT_087_00020 GOSPT_054_00130 GOSPT_051_00380 GOSPT_042_00240 GOSPT_006_00540 |
|---|
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | GOSPT_058_00080 GOSPT_045_00100 GOSPT_152_00300 GOSPT_141_00330 GOSPT_109_00160 GOSPT_065_00780 GOSPT_045_00330 GOSPT_044_00070 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | GOSPT_096_00080 GOSPT_025_00720 |
Arsenical resistance(NFUNC_0004) |
| 必須 | A | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | |
|---|
ARSC1 (NRULE_0017) | Arsenate reductase | GOSPT_089_00550 |
| B | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | |
ARSC2 (NRULE_0018) | Arsenate reductase | |
| C | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | |
ARSC3 (NRULE_0019) | Arsenate reductase | |
| D | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | GOSPT_082_00120 |
ARSC1 (NRULE_0017) | Arsenate reductase | GOSPT_089_00550 |
| E | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | GOSPT_082_00120 |
ARSC2 (NRULE_0018) | Arsenate reductase | |
| F | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | GOSPT_082_00120 |
ARSC3 (NRULE_0019) | Arsenate reductase | |
| 任意 | | ARSA (NRULE_0014) | Arsenical pump-driving ATPase | |
|---|
| | ARSD (NRULE_0020) | Arsenical resistance operon trans-acting repressor ArsD | |
| | ARSH (NRULE_0021) | ArsH protein | |
Artificial lacto-N-biose biosynthesis(NFUNC_0026) |
| 必須 | A | SP (NRULE_0109) | Sucrose phosphorylase | |
|---|
GALT (NRULE_0110) | Galactose-1-phosphate uridylyltransferase | |
GALE (NRULE_0111) | UDP-glucose 4-epimerase | GOSPT_080_00710 |
LNBP (NRULE_0112) | 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase | |
Bacitracin resistance(NFUNC_0022) |
| 必須 | A | UPPP (NRULE_0097) | Undecaprenyl-diphosphatase | GOSPT_022_01600 GOSPT_077_00030 GOSPT_051_00930 |
|---|
Benzoate degradation (via hydroxylation by dioxygenase)(NFUNC_0017) |
| 必須 | A | BENA (NRULE_0046) | Benzoate 1,2-dioxygenase alpha subunit | GOSPT_141_00330 |
|---|
BENB (NRULE_0047) | Benzoate 1,2-dioxygenase beta subunit | GOSPT_141_00320 |
BEND (NRULE_0082) | 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase | GOSPT_141_00310 |
| 任意 | | BENC (NRULE_0055) | Benzoate 1,2-dioxygenase electron transfer component | GOSPT_141_00310 |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | GOSPT_109_00150 GOSPT_006_00540 GOSPT_042_00240 GOSPT_051_00380 GOSPT_054_00130 GOSPT_069_00110 GOSPT_087_00020 GOSPT_089_00190 GOSPT_141_00310 GOSPT_117_00460 GOSPT_096_00110 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | GOSPT_109_00160 GOSPT_065_00780 GOSPT_141_00330 GOSPT_045_00100 GOSPT_152_00300 GOSPT_045_00330 GOSPT_044_00070 GOSPT_058_00080 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | GOSPT_096_00080 GOSPT_025_00720 |
Betaine biosynthesis (from choline)(NFUNC_0049) |
| 必須 | A | BETA (NRULE_0175) | Choline dehydrogenase | |
|---|
| B | GBSB (NRULE_0176) | Alcohol dehydrogenase | |
BETB (NRULE_0177) | Betaine aldehyde dehydrogenase | |
| C | CHOX (NRULE_0178) | Choline oxidase | GOSPT_109_00030 |
Biotin biosynthesis(NFUNC_0051) |
| 必須 | A | BIOF (NRULE_0182) | 8-amino-7-oxononanoate synthase | |
|---|
BIOA (NRULE_0183) | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | GOSPT_058_00880 |
BIOD (NRULE_0184) | ATP-dependent dethiobiotin synthetase BioD | GOSPT_058_00900 |
BIOB (NRULE_0185) | Biotin synthase | GOSPT_058_00910 |
Catechol degradation (beta-ketoadipate pathway)(NFUNC_0013) |
| 必須 | A | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | |
|---|
CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | |
CATC (NRULE_0054) | Muconolactone isomerase | |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | GOSPT_141_00270 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | GOSPT_141_00280 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | GOSPT_141_00260 GOSPT_045_01110 |
| B | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | |
CATC (NRULE_0054) | Muconolactone isomerase | |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | GOSPT_141_00270 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | GOSPT_141_00280 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | GOSPT_141_00260 GOSPT_045_01110 |
CATB1 (NRULE_0386) | Muconate cycloisomerase | |
| C | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | |
CATC (NRULE_0054) | Muconolactone isomerase | |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | GOSPT_141_00280 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | GOSPT_141_00260 GOSPT_045_01110 |
CATB1 (NRULE_0386) | Muconate cycloisomerase | |
| D | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | |
CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | |
CATC (NRULE_0054) | Muconolactone isomerase | |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | GOSPT_141_00280 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | GOSPT_045_01110 GOSPT_141_00260 |
Chlorocatechol degradation (beta-ketoadipate pathway)(NFUNC_0104) |
| 必須 | A | PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | GOSPT_141_00280 |
|---|
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | GOSPT_141_00260 GOSPT_045_01110 |
CLCA (NRULE_0382) | Chlorocatechol 1,2-dioxygenase | |
CLCD (NRULE_0383) | Dienelactone hydrolase | GOSPT_099_00620 GOSPT_025_00020 GOSPT_042_00550 GOSPT_044_00200 GOSPT_059_00850 GOSPT_080_00680 |
CLCE (NRULE_0384) | Maleylacetate reductase | |
CLCB (NRULE_0387) | Chloromuconate cycloisomerase | |
| B | CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | GOSPT_141_00280 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | GOSPT_141_00260 GOSPT_045_01110 |
CLCA (NRULE_0382) | Chlorocatechol 1,2-dioxygenase | |
CLCD (NRULE_0383) | Dienelactone hydrolase | GOSPT_044_00200 GOSPT_099_00620 GOSPT_080_00680 GOSPT_059_00850 GOSPT_025_00020 GOSPT_042_00550 |
CLCE (NRULE_0384) | Maleylacetate reductase | |
| 任意 | | CLCF (NRULE_0385) | Chloromuconolactone dehalogenase | |
|---|
Dibenzothiophene degradation (via desulfurization)(NFUNC_0029) |
| 必須 | A | DSZA (NRULE_0103) | Dibenzothiophene-5,5-dioxide monooxygenase | |
|---|
DSZB (NRULE_0104) | 2'-hydroxybiphenyl-2-sulfinate desulfinase | |
DSZC (NRULE_0105) | Dibenzothiophene monooxygenase | |
| 任意 | | FADR1 (NRULE_0101) | NADH-dependent flavin reductase | GOSPT_028_00050 GOSPT_085_00850 GOSPT_045_00360 GOSPT_004_00390 |
|---|
Dihydroxy aromatic compounds degradation (via meta-cleavage pathway)(NFUNC_0011) |
| 必須 | A | EDIO (NRULE_0058) | extradiol dioxygenase | GOSPT_045_00350 GOSPT_044_00150 |
|---|
METAH (NRULE_0059) | meta-cleavage compound hydrolase | |
HPDH (NRULE_0063) | 2-hydroxypent-2,4-dienoate hydratase | |
HOA (NRULE_0064) | 4-hydroxy-2-oxovalerate aldolase | GOSPT_022_02640 GOSPT_096_00220 GOSPT_045_00280 |
ACDH (NRULE_0065) | Acetaldehyde dehydrogenase | GOSPT_096_00230 GOSPT_022_02650 GOSPT_045_00270 |
| B | EDIO (NRULE_0058) | extradiol dioxygenase | GOSPT_045_00350 GOSPT_044_00150 |
2HMSD (NRULE_0060) | 2-hydroxymuconic semialdehyde dehydrogenase | |
4OT (NRULE_0061) | 4-oxalocrotonate tautomerase | |
4OD (NRULE_0062) | 4-oxalocrotonate decarboxylase | |
HPDH (NRULE_0063) | 2-hydroxypent-2,4-dienoate hydratase | |
HOA (NRULE_0064) | 4-hydroxy-2-oxovalerate aldolase | GOSPT_096_00220 GOSPT_045_00280 GOSPT_022_02640 |
ACDH (NRULE_0065) | Acetaldehyde dehydrogenase | GOSPT_022_02650 GOSPT_096_00230 GOSPT_045_00270 |
Ectoine biosynthesis(NFUNC_0056) |
| 必須 | A | ECTB (NRULE_0186) | Diaminobutyrate--2-oxoglutarate transaminase | GOSPT_051_00830 |
|---|
ECTA (NRULE_0187) | L-2,4-diaminobutyric acid acetyltransferase | GOSPT_051_00820 |
ECTC (NRULE_0188) | L-ectoine synthase | GOSPT_051_00840 |
Folate biosynthesis(NFUNC_0044) |
| 必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | GOSPT_062_00180 |
|---|
DHPS (NRULE_0144) | Dihydropteroate synthase | GOSPT_103_00590 GOSPT_098_00050 |
FOLM (NRULE_0146) | Dihydrofolate reductase FolM | |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | GOSPT_103_00580 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | GOSPT_103_00570 |
FOLC (NRULE_0160) | Bifunctional protein FolC | GOSPT_051_00950 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | |
| B | GLAT (NRULE_0142) | Glutamine amidotransferase | GOSPT_062_00180 |
DHPS (NRULE_0144) | Dihydropteroate synthase | GOSPT_103_00590 GOSPT_098_00050 |
FOLA (NRULE_0147) | Dihydrofolate reductase | GOSPT_046_00370 |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | GOSPT_103_00580 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | GOSPT_103_00570 |
FOLC (NRULE_0160) | Bifunctional protein FolC | GOSPT_051_00950 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | |
| C | GLAT (NRULE_0142) | Glutamine amidotransferase | GOSPT_062_00180 |
DHPS (NRULE_0144) | Dihydropteroate synthase | GOSPT_103_00590 GOSPT_098_00050 |
DFR2 (NRULE_0148) | Dihydrofolate reductase type 2 | |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | GOSPT_103_00580 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | GOSPT_103_00570 |
FOLC (NRULE_0160) | Bifunctional protein FolC | GOSPT_051_00950 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | |
GABA biosynthesis(NFUNC_0066) |
| 必須 | A | GAD (NRULE_0231) | Glutamate decarboxylase | GOSPT_091_00050 |
|---|
Haloalkane degradation (conversion into hydroxyacid)(NFUNC_0010) |
| 必須 | A | DHAA (NRULE_0050) | Haloalkane dehalogenase | |
|---|
HAD (NRULE_0051) | (S)-2-haloacid dehalogenase | GOSPT_005_00380 |
| B | DHAA (NRULE_0050) | Haloalkane dehalogenase | |
DEH (NRULE_0075) | Haloacetate dehalogenase | |
Human milk oligosaccharides metabolism(NFUNC_0083) |
| 必須 | A | LNBP (NRULE_0112) | 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase | |
|---|
| 任意 | | NAHK (NRULE_0256) | N-acetylhexosamine 1-kinase | |
|---|
| | GALT (NRULE_0110) | Galactose-1-phosphate uridylyltransferase | |
| | GALE (NRULE_0111) | UDP-glucose 4-epimerase | GOSPT_080_00710 |
Hydroxyectoine biosynthesis(NFUNC_0057) |
| 必須 | A | ECTD (NRULE_0189) | Ectoine hydroxylase | GOSPT_004_00560 |
|---|
| 任意 | | ECTB (NRULE_0186) | Diaminobutyrate--2-oxoglutarate transaminase | GOSPT_051_00830 |
|---|
| | ECTA (NRULE_0187) | L-2,4-diaminobutyric acid acetyltransferase | GOSPT_051_00820 |
| | ECTC (NRULE_0188) | L-ectoine synthase | GOSPT_051_00840 |
4-hydroxyphenylacetate degradation(NFUNC_0068) |
| 必須 | A | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
|---|
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| B | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| C | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | GOSPT_085_00850 GOSPT_045_00360 GOSPT_028_00050 GOSPT_004_00390 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| D | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | GOSPT_004_00390 GOSPT_045_00360 GOSPT_028_00050 GOSPT_085_00850 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| E | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | GOSPT_028_00050 GOSPT_085_00850 GOSPT_045_00360 GOSPT_004_00390 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| F | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | GOSPT_085_00850 GOSPT_028_00050 GOSPT_045_00360 GOSPT_004_00390 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| G | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| H | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
Mercury resistance(NFUNC_0005) |
| 必須 | A | MERA (NRULE_0008) | Mercuric reductase | GOSPT_024_00050 |
|---|
Metal-binding protein(NFUNC_0105) |
| 必須 | A | MOP (NRULE_0322) | Putative molybdenum-binding protein | GOSPT_009_00160 GOSPT_007_00060 GOSPT_086_00140 GOSPT_052_00070 |
|---|
| B | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | |
| C | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | GOSPT_052_00100 GOSPT_086_00150 |
| D | MNTR (NRULE_0327) | DtxR family transcriptional regulator MntR | |
| E | CUER (NRULE_0328) | Copper-responsive transcriptional regulator CueR | |
| F | SOXR (NRULE_0329) | Redox-sensitive transcriptional activator SoxR | GOSPT_089_00010 |
| G | ZNTR (NRULE_0330) | Zinc-responsive transcriptional regulator ZntR | |
| H | NIKR (NRULE_0331) | Nickel-responsive transcriptional regulator NikR | |
| I | ISCR (NRULE_0332) | Rrf2 family transcriptional regulator IscR | |
| J | SMTA (NRULE_0009) | Metallothionein | |
Molybdate transport (ABC transporter)(NFUNC_0097) |
| 必須 | A | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | GOSPT_052_00100 GOSPT_086_00150 |
|---|
| 任意 | | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | |
|---|
| | MODB (NRULE_0325) | Molybdate ABC transporter permease protein | GOSPT_086_00160 |
| | MODC (NRULE_0326) | Molybdate ABC transporter ATP-binding protein | |
Mycosamine biosynthesis(NFUNC_0095) |
| 必須 | A | AMPHDII (NRULE_0342) | GDP-3-keto-6-deoxy-D-mannose C-3 aminotransferase | |
|---|
GMD (NRULE_0343) | GDP-mannose 4,6-dehydratase | GOSPT_125_00670 |
| 任意 | | AMPHDI (NRULE_0341) | GDP-mycosamine glycosyltransferase | |
|---|
Naphthalene degradation (via hydroxylation by dioxygenase)(NFUNC_0067) |
| 必須 | A | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | GOSPT_044_00070 GOSPT_141_00330 GOSPT_109_00160 |
|---|
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | GOSPT_044_00080 GOSPT_141_00320 |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
EDIO (NRULE_0058) | extradiol dioxygenase | GOSPT_044_00150 GOSPT_045_00350 |
NAHD (NRULE_0171) | 2-hydroxychromene-2-carboxylate isomerase | |
NAHE (NRULE_0172) | Trans-O-hydroxybenzylidenepyruvate hydratase-aldolase | |
NAHF (NRULE_0173) | Salicylaldehyde dehydrogenase | |
NAHG (NRULE_0190) | Salicylate hydroxylase | |
| B | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | GOSPT_109_00160 GOSPT_044_00070 GOSPT_141_00330 |
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | GOSPT_141_00320 GOSPT_044_00080 |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
EDIO (NRULE_0058) | extradiol dioxygenase | GOSPT_044_00150 GOSPT_045_00350 |
NAHD (NRULE_0171) | 2-hydroxychromene-2-carboxylate isomerase | |
NAHE (NRULE_0172) | Trans-O-hydroxybenzylidenepyruvate hydratase-aldolase | |
NAHF (NRULE_0173) | Salicylaldehyde dehydrogenase | |
NAGG (NRULE_0191) | Salicylate 5-hydroxylase alpha subunit | |
NAGH (NRULE_0192) | Salicylate 5-hydroxylase beta subunit | |
| 任意 | | FDR1 (NRULE_0032) | Oxygenase electron transfer component | GOSPT_042_00240 GOSPT_006_00540 GOSPT_051_00380 GOSPT_054_00130 GOSPT_069_00110 GOSPT_087_00020 GOSPT_089_00190 GOSPT_096_00110 GOSPT_109_00150 GOSPT_117_00460 GOSPT_141_00310 |
|---|
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | GOSPT_065_00780 GOSPT_045_00330 GOSPT_045_00100 GOSPT_044_00070 GOSPT_141_00330 GOSPT_109_00160 GOSPT_058_00080 GOSPT_152_00300 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | GOSPT_025_00720 GOSPT_096_00080 |
Nitrile hydratase(NFUNC_0002) |
| 必須 | A | NHAA (NRULE_0001) | Nitrile hydratase subunit alpha | |
|---|
NHAB (NRULE_0002) | Nitrile hydratase subunit beta | |
| 任意 | | P14K (NRULE_0006) | Nitrile hydratase activator P14K | |
|---|
| | COBW (NRULE_0007) | CobW/P47K family protein | GOSPT_018_00230 GOSPT_113_00040 |
(R)-pantothenate biosynthesis(NFUNC_0030) |
| 必須 | A | PAND (NRULE_0115) | Aspartate 1-decarboxylase | GOSPT_103_00510 |
|---|
PANB (NRULE_0116) | 3-methyl-2-oxobutanoate hydroxymethyltransferase | GOSPT_072_00340 |
PANE (NRULE_0117) | 2-dehydropantoate 2-reductase | GOSPT_088_00210 |
PANC (NRULE_0118) | Pantothenate synthetase | GOSPT_103_00530 |
Phenol degradation(NFUNC_0028) |
| 必須 | A | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | GOSPT_087_00030 GOSPT_087_00010 |
|---|
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | GOSPT_087_00010 GOSPT_087_00030 |
MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
| B | PHEA1 (NRULE_0083) | Aromatic ring hydroxylase | |
| C | PHEA2 (NRULE_0084) | Aromatic ring hydroxylase | GOSPT_003_00210 |
| 任意 | | FDR2 (NRULE_0057) | Ferredoxin reductase | GOSPT_096_00080 GOSPT_025_00720 |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | GOSPT_089_00190 GOSPT_141_00310 GOSPT_117_00460 GOSPT_109_00150 GOSPT_096_00110 GOSPT_087_00020 GOSPT_069_00110 GOSPT_054_00130 GOSPT_051_00380 GOSPT_042_00240 GOSPT_006_00540 |
| | MME (NRULE_0033) | Multicomponent monooxygenase effector protein | GOSPT_087_00050 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | GOSPT_141_00330 GOSPT_058_00080 GOSPT_065_00780 GOSPT_109_00160 GOSPT_152_00300 GOSPT_044_00070 GOSPT_045_00100 GOSPT_045_00330 |
| | FADR1 (NRULE_0101) | NADH-dependent flavin reductase | GOSPT_045_00360 GOSPT_028_00050 GOSPT_004_00390 GOSPT_085_00850 |
Protocatechuate degradation (beta-ketoadipate pathway)(NFUNC_0014) |
| 必須 | A | PCAG (NRULE_0066) | Protocatechuate 3,4-dioxygenase alpha subunit | GOSPT_056_00130 |
|---|
PCAH (NRULE_0067) | Protocatechuate 3,4-dioxygenase beta subunit | GOSPT_056_00140 |
PCAB (NRULE_0068) | 3-carboxy-cis,cis-muconate cycloisomerase | |
PCAC (NRULE_0069) | 4-carboxymuconolactone decarboxylase | GOSPT_056_00110 |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | GOSPT_141_00270 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | GOSPT_141_00280 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | GOSPT_045_01110 GOSPT_141_00260 |
| B | PCAG (NRULE_0066) | Protocatechuate 3,4-dioxygenase alpha subunit | GOSPT_056_00130 |
PCAH (NRULE_0067) | Protocatechuate 3,4-dioxygenase beta subunit | GOSPT_056_00140 |
PCAB (NRULE_0068) | 3-carboxy-cis,cis-muconate cycloisomerase | |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | GOSPT_141_00280 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | GOSPT_045_01110 GOSPT_141_00260 |
Riboflavin biosynthesis(NFUNC_0058) |
| 必須 | A | RIBB (NRULE_0200) | 3,4-dihydroxy-2-butanone 4-phosphate synthase | GOSPT_022_00650 |
|---|
RIBA (NRULE_0201) | GTP cyclohydrolase-2 | GOSPT_022_00650 GOSPT_085_00180 |
RIBD (NRULE_0202) | Riboflavin biosynthesis protein RibD | |
RIBH (NRULE_0203) | 6,7-dimethyl-8-ribityllumazine synthase | GOSPT_022_00660 |
RIBE (NRULE_0204) | Riboflavin synthase | GOSPT_022_00640 |
| 任意 | | RIBF (NRULE_0205) | Riboflavin biosynthesis protein RibF | GOSPT_046_00190 |
|---|
Toluene degradation (conversion into protocatechuate via p-cresol)(NFUNC_0007) |
| 必須 | A | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | GOSPT_087_00010 GOSPT_087_00030 |
|---|
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | GOSPT_087_00030 GOSPT_087_00010 |
FDR1 (NRULE_0032) | Oxygenase electron transfer component | GOSPT_096_00110 GOSPT_087_00020 GOSPT_141_00310 GOSPT_117_00460 GOSPT_109_00150 GOSPT_089_00190 GOSPT_006_00540 GOSPT_042_00240 GOSPT_051_00380 GOSPT_054_00130 GOSPT_069_00110 |
MME (NRULE_0033) | Multicomponent monooxygenase effector protein | GOSPT_087_00050 |
PCHF (NRULE_0035) | 4-cresol dehydrogenase flavoprotein subunit | |
PCHC (NRULE_0036) | 4-cresol dehydrogenase cytochrome c subunit | |
PCHA (NRULE_0037) | p-hydroxybenzaldehyde dehydrogenase | |
POBA (NRULE_0038) | p-hydroxybenzoate hydroxylase | |
| 任意 | | MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
|---|
| | MMG2 (NRULE_0030) | Multicomponent monooxygenase gamma subunit | |
| | MMG3 (NRULE_0031) | Multicomponent monooxygenase gamma subunit | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | GOSPT_058_00080 GOSPT_044_00070 GOSPT_045_00100 GOSPT_045_00330 GOSPT_141_00330 GOSPT_065_00780 GOSPT_109_00160 GOSPT_152_00300 |
Trehalose biosynthesis (from maltooligosaccharide)(NFUNC_0037) |
| 必須 | A | TREY (NRULE_0140) | Maltooligosyl trehalose synthase | GOSPT_058_00840 |
|---|
TREZ (NRULE_0141) | Malto-oligosyltrehalose trehalohydrolase | GOSPT_058_00740 |
| 任意 | | GLGX (NRULE_0139) | Glycogen debranching enzyme | GOSPT_072_00120 GOSPT_058_00850 |
|---|
Trehalose biosynthesis (from NDP-glucose and glucose-6-phosphate)(NFUNC_0031) |
| 必須 | A | TPS (NRULE_0119) | Trehalose-phosphate synthase | GOSPT_142_00060 |
|---|
TPP (NRULE_0120) | Trehalose-6-phosphate phosphatase | GOSPT_142_00070 |
Uptake of osmoprotectant(NFUNC_0061) |
| 必須 | A | OPUAC (NRULE_0213) | Osmoprotectant ABC transporter substrate-binding protein | |
|---|
OPUAB (NRULE_0214) | Osmoprotectant ABC transporter permease protein | |
OPUAA (NRULE_0215) | Osmoprotectant ABC transporter ATP-binding protein | |
| B | EHUB (NRULE_0216) | Ectoine ABC transporter substrate-binding protein | |
EHUC (NRULE_0217) | Ectoine ABC transporter permease protein | |
EHUD (NRULE_0218) | Ectoine ABC transporter permease protein | |
EHUA (NRULE_0219) | Ectoine ABC transporter ATP-binding protein | |
| C | BCCT (NRULE_0220) | BCCT family transporter | GOSPT_109_00070 |
| D | PROP (NRULE_0221) | Osmoprotectant transporter | |
| E | OPUE (NRULE_0222) | Sodium/proline symporter | |
| F | TEAA (NRULE_0223) | TRAP transporter substrate-binding protein TeaA | |
TEAB (NRULE_0224) | TRAP transporter small transmembrane protein TeaB | |
TEAC (NRULE_0225) | TRAP transporter large transmembrane protein TeaC | |
Vitamin B6 biosynthesis (PdxA/PdxJ pathway)(NFUNC_0060) |
| 必須 | A | EPD (NRULE_0208) | D-erythrose-4-phosphate dehydrogenase | |
|---|
PDXB (NRULE_0209) | Erythronate-4-phosphate dehydrogenase | |
SERC (NRULE_0210) | Phosphoserine aminotransferase | GOSPT_079_00100 |
PDXA (NRULE_0211) | 4-hydroxythreonine-4-phosphate dehydrogenase | |
PDXJ (NRULE_0212) | Pyridoxine 5'-phosphate synthase | |
Vitamin B6 biosynthesis (PdxS/PdxT pathway)(NFUNC_0059) |
| 必須 | A | PDXS (NRULE_0206) | Pyridoxal biosynthesis lyase PdxS | GOSPT_064_00070 |
|---|
PDXT (NRULE_0207) | Glutamine amidotransferase subunit PdxT | GOSPT_064_00020 |
