Acid resistance (by GABA antiporter)(NFUNC_0071) |
| Require | A | GAD (NRULE_0231) | Glutamate decarboxylase | Caci_8660 |
|---|
GADC (NRULE_0234) | Glutamate/gamma-aminobutyrate antiporter | |
Alanine racemization(NFUNC_0063) |
| Require | A | ALR (NRULE_0228) | Alanine racemase | Caci_0990 |
|---|
Alginate degradation(NFUNC_0062) |
| Require | A | ALGL (NRULE_0226) | Alginate lyase | |
|---|
| B | ALY (NRULE_0227) | Alginate lyase | Caci_7491 Caci_1606 |
n-alkane hydroxylation(NFUNC_0008) |
| Require | A | CYP153 (NRULE_0041) | Cytochrome P450 CYP153 | |
|---|
| B | ALKB (NRULE_0024) | Alkane 1-monooxygenase | Caci_1373 |
| C | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | |
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | |
FDR1 (NRULE_0032) | Oxygenase electron transfer component | Caci_1748 Caci_4894 Caci_3827 |
MME (NRULE_0033) | Multicomponent monooxygenase effector protein | |
| Participant | | RUBA (NRULE_0039) | Rubredoxin | |
|---|
| | RUBB (NRULE_0040) | Rubredoxin reductase | |
| | MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
| | MMG2 (NRULE_0030) | Multicomponent monooxygenase gamma subunit | |
| | MMG3 (NRULE_0031) | Multicomponent monooxygenase gamma subunit | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | Caci_4895 Caci_4533 Caci_4400 Caci_4332 Caci_2527 Caci_2265 Caci_2184 Caci_1679 Caci_0421 Caci_0116 Caci_5615 Caci_7447 Caci_4970 |
D-allose biosynthesis(NFUNC_0077) |
| Require | A | LRHI (NRULE_0242) | L-rhamnose isomerase | Caci_6712 |
|---|
Aminoglycoside resistance (by aminoglycoside N-acetyltransferase)(NFUNC_0041) |
| Require | A | AAC3 (NRULE_0149) | Aminoglycoside N(3')-acetyltransferase | Caci_0513 |
|---|
| B | AAC6 (NRULE_0150) | Aminoglycoside N(6')-acetyltransferase | |
Aminoglycoside resistance (by aminoglycoside O-nucleotidyltransferase)(NFUNC_0042) |
| Require | A | ANT6 (NRULE_0151) | Aminoglycoside 6-adenylyltransferase | |
|---|
| B | ANT4 (NRULE_0152) | Kanamycin nucleotidyltransferase | |
| C | ANT2 (NRULE_0153) | 2''-aminoglycoside nucleotidyltransferase | Caci_4744 |
| D | ANT3 (NRULE_0154) | Streptomycin 3''-adenylyltransferase | |
Aminoglycoside resistance (by aminoglycoside O-phosphotransferase)(NFUNC_0043) |
| Require | A | APH6 (NRULE_0155) | Streptomycin 6-kinase | |
|---|
| B | APH3 (NRULE_0156) | Aminoglycoside 3'-phosphotransferase | Caci_6179 |
| C | APH7 (NRULE_0157) | Hygromycin-B 7''-O-kinase | |
| D | HPH (NRULE_0174) | Hygromycin-B 4-O-kinase | |
Ampicillin resistance(NFUNC_0046) |
| Require | A | BLAA (NRULE_0122) | Beta-lactamase class A | Caci_5163 |
|---|
| Participant | | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
|---|
| | BLAD (NRULE_0125) | Beta-lactamase class D | |
Aniline degradation (conversion into catechol)(NFUNC_0075) |
| Require | A | ATDA1 (NRULE_0240) | Gamma-glutamylanilide synthetase | |
|---|
ATDA3 (NRULE_0357) | Aniline dioxygenase large subunit | |
ATDA4 (NRULE_0358) | Aniline dioxygenase small subunit | |
| Participant | | ATDA2 (NRULE_0241) | Putative gamma-glutamylanilide hydrolase | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | Caci_4894 Caci_1748 Caci_3827 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | Caci_4332 Caci_0116 Caci_0421 Caci_1679 Caci_2184 Caci_2265 Caci_2527 Caci_4400 Caci_4533 Caci_4895 Caci_4970 Caci_5615 Caci_7447 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | Caci_1305 Caci_2641 |
Anthranilate biosynthesis(NFUNC_0038) |
| Require | A | GLAT (NRULE_0142) | Glutamine amidotransferase | Caci_3668 Caci_0039 |
|---|
TRPE (NRULE_0143) | Anthranilate synthase component I | Caci_5714 |
Anthranilate degradation (via hydroxylation)(NFUNC_0018) |
| Require | A | ANTA (NRULE_0044) | Anthranilate 1,2-dioxygenase large subunit | |
|---|
ANTB (NRULE_0045) | Anthranilate 1,2-dioxygenase small subunit | |
| Participant | | ANTC (NRULE_0081) | Anthranilate 1,2-dioxygenase electron transfer component | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | Caci_1748 Caci_4894 Caci_3827 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | Caci_4332 Caci_2527 Caci_2265 Caci_2184 Caci_1679 Caci_4895 Caci_4970 Caci_5615 Caci_0421 Caci_0116 Caci_7447 Caci_4533 Caci_4400 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | Caci_1305 Caci_2641 |
Aromatic azo compounds degradation(NFUNC_0073) |
| Require | A | AZOR (NRULE_0236) | FMN-dependent NADH-azoreductase | Caci_6778 |
|---|
| B | AZR (NRULE_0237) | NADPH azoreductase | |
| C | AZOB (NRULE_0238) | NAD(P)H azoreductase | |
Aromatic hydrocarbon degradation (via hydroxylation by dioxygenase)(NFUNC_0016) |
| Require | A | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | Caci_7447 |
|---|
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
| Participant | | FDR1 (NRULE_0032) | Oxygenase electron transfer component | Caci_1748 Caci_3827 Caci_4894 |
|---|
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | Caci_2527 Caci_4970 Caci_0116 Caci_1679 Caci_2184 Caci_2265 Caci_4332 Caci_4400 Caci_4533 Caci_4895 Caci_0421 Caci_7447 Caci_5615 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | Caci_1305 Caci_2641 |
Artificial lacto-N-biose biosynthesis(NFUNC_0026) |
| Require | A | SP (NRULE_0109) | Sucrose phosphorylase | |
|---|
GALT (NRULE_0110) | Galactose-1-phosphate uridylyltransferase | Caci_7278 |
GALE (NRULE_0111) | UDP-glucose 4-epimerase | Caci_1465 Caci_8174 |
LNBP (NRULE_0112) | 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase | |
Bacitracin resistance(NFUNC_0022) |
| Require | A | UPPP (NRULE_0097) | Undecaprenyl-diphosphatase | Caci_7544 |
|---|
Benzoate degradation (via hydroxylation by dioxygenase)(NFUNC_0017) |
| Require | A | BENA (NRULE_0046) | Benzoate 1,2-dioxygenase alpha subunit | |
|---|
BENB (NRULE_0047) | Benzoate 1,2-dioxygenase beta subunit | |
BEND (NRULE_0082) | 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase | |
| Participant | | BENC (NRULE_0055) | Benzoate 1,2-dioxygenase electron transfer component | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | Caci_4894 Caci_1748 Caci_3827 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | Caci_4533 Caci_4400 Caci_4895 Caci_7447 Caci_5615 Caci_0116 Caci_0421 Caci_1679 Caci_2184 Caci_2265 Caci_2527 Caci_4332 Caci_4970 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | Caci_2641 Caci_1305 |
Beta-lactam antibiotic resistance(NFUNC_0033) |
| Require | A | BLAA (NRULE_0122) | Beta-lactamase class A | Caci_5163 |
|---|
| B | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
| C | BLAC (NRULE_0124) | Beta-lactamase class C | |
| D | BLAD (NRULE_0125) | Beta-lactamase class D | |
Bioplastic degradation(NFUNC_0015) |
| Require | A | PHAZ1 (NRULE_0023) | Intracellular poly(3-hydroxyalkanoate) depolymerase | |
|---|
| B | PHAZ2 (NRULE_0080) | Poly(3-hydroxyalkanoate) depolymerase | Caci_4958 Caci_3290 Caci_3591 |
| C | PHAZ3 (NRULE_0088) | Poly(3-hydroxyalkanoate) depolymerase | |
| Participant | | PHAY (NRULE_0022) | D-(-)-3-hydroxybutyrate oligomer hydrolase | |
|---|
Biotin biosynthesis(NFUNC_0051) |
| Require | A | BIOF (NRULE_0182) | 8-amino-7-oxononanoate synthase | |
|---|
BIOA (NRULE_0183) | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | Caci_5982 |
BIOD (NRULE_0184) | ATP-dependent dethiobiotin synthetase BioD | Caci_7723 |
BIOB (NRULE_0185) | Biotin synthase | Caci_4597 Caci_7724 |
Catechol degradation (beta-ketoadipate pathway)(NFUNC_0013) |
| Require | A | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | |
|---|
CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | |
CATC (NRULE_0054) | Muconolactone isomerase | |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | Caci_4887 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | Caci_4338 Caci_4892 Caci_7914 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | Caci_4339 Caci_7913 Caci_4891 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | Caci_6183 |
| B | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | |
CATC (NRULE_0054) | Muconolactone isomerase | |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | Caci_4887 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | Caci_4892 Caci_4338 Caci_7914 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | Caci_4339 Caci_4891 Caci_7913 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | Caci_6183 |
CATB1 (NRULE_0386) | Muconate cycloisomerase | |
| C | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | |
CATC (NRULE_0054) | Muconolactone isomerase | |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | Caci_4887 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | Caci_7914 Caci_4338 Caci_4892 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | Caci_4339 Caci_4891 Caci_7913 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | Caci_6183 |
CATB1 (NRULE_0386) | Muconate cycloisomerase | |
| D | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | |
CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | |
CATC (NRULE_0054) | Muconolactone isomerase | |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | Caci_4887 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | Caci_4338 Caci_7914 Caci_4892 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | Caci_4891 Caci_4339 Caci_7913 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | Caci_6183 |
Cephalosporin resistance(NFUNC_0048) |
| Require | A | BLAC (NRULE_0124) | Beta-lactamase class C | |
|---|
| Participant | | BLAA (NRULE_0122) | Beta-lactamase class A | Caci_5163 |
|---|
| | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
Chlorocatechol degradation (beta-ketoadipate pathway)(NFUNC_0104) |
| Require | A | PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | Caci_7914 Caci_4892 Caci_4338 |
|---|
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | Caci_7913 Caci_4891 Caci_4339 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | Caci_6183 |
CLCA (NRULE_0382) | Chlorocatechol 1,2-dioxygenase | |
CLCD (NRULE_0383) | Dienelactone hydrolase | Caci_5082 Caci_5204 Caci_6460 Caci_1119 Caci_1640 Caci_1727 Caci_1971 Caci_3269 Caci_3453 Caci_4911 |
CLCE (NRULE_0384) | Maleylacetate reductase | |
CLCB (NRULE_0387) | Chloromuconate cycloisomerase | |
| B | CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | Caci_7914 Caci_4892 Caci_4338 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | Caci_7913 Caci_4339 Caci_4891 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | Caci_6183 |
CLCA (NRULE_0382) | Chlorocatechol 1,2-dioxygenase | |
CLCD (NRULE_0383) | Dienelactone hydrolase | Caci_1119 Caci_6460 Caci_5204 Caci_5082 Caci_4911 Caci_3453 Caci_3269 Caci_1971 Caci_1727 Caci_1640 |
CLCE (NRULE_0384) | Maleylacetate reductase | |
| Participant | | CLCF (NRULE_0385) | Chloromuconolactone dehalogenase | |
|---|
Dibenzothiophene degradation (via desulfurization)(NFUNC_0029) |
| Require | A | DSZA (NRULE_0103) | Dibenzothiophene-5,5-dioxide monooxygenase | |
|---|
DSZB (NRULE_0104) | 2'-hydroxybiphenyl-2-sulfinate desulfinase | |
DSZC (NRULE_0105) | Dibenzothiophene monooxygenase | |
| Participant | | FADR1 (NRULE_0101) | NADH-dependent flavin reductase | Caci_2759 Caci_8752 Caci_5960 Caci_6349 Caci_6495 Caci_7867 Caci_3558 Caci_3777 |
|---|
Dihydroxy aromatic compounds degradation (via meta-cleavage pathway)(NFUNC_0011) |
| Require | A | EDIO (NRULE_0058) | extradiol dioxygenase | Caci_1819 |
|---|
METAH (NRULE_0059) | meta-cleavage compound hydrolase | |
HPDH (NRULE_0063) | 2-hydroxypent-2,4-dienoate hydratase | |
HOA (NRULE_0064) | 4-hydroxy-2-oxovalerate aldolase | |
ACDH (NRULE_0065) | Acetaldehyde dehydrogenase | |
| B | EDIO (NRULE_0058) | extradiol dioxygenase | Caci_1819 |
2HMSD (NRULE_0060) | 2-hydroxymuconic semialdehyde dehydrogenase | |
4OT (NRULE_0061) | 4-oxalocrotonate tautomerase | |
4OD (NRULE_0062) | 4-oxalocrotonate decarboxylase | |
HPDH (NRULE_0063) | 2-hydroxypent-2,4-dienoate hydratase | |
HOA (NRULE_0064) | 4-hydroxy-2-oxovalerate aldolase | |
ACDH (NRULE_0065) | Acetaldehyde dehydrogenase | |
Folate biosynthesis(NFUNC_0044) |
| Require | A | GLAT (NRULE_0142) | Glutamine amidotransferase | Caci_3668 Caci_0039 |
|---|
DHPS (NRULE_0144) | Dihydropteroate synthase | Caci_7946 Caci_8423 |
FOLM (NRULE_0146) | Dihydrofolate reductase FolM | |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | Caci_8421 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | Caci_8420 |
FOLC (NRULE_0160) | Bifunctional protein FolC | Caci_7289 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | |
| B | GLAT (NRULE_0142) | Glutamine amidotransferase | Caci_0039 Caci_3668 |
DHPS (NRULE_0144) | Dihydropteroate synthase | Caci_7946 Caci_8423 |
FOLA (NRULE_0147) | Dihydrofolate reductase | |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | Caci_8421 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | Caci_8420 |
FOLC (NRULE_0160) | Bifunctional protein FolC | Caci_7289 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | |
| C | GLAT (NRULE_0142) | Glutamine amidotransferase | Caci_3668 Caci_0039 |
DHPS (NRULE_0144) | Dihydropteroate synthase | Caci_8423 Caci_7946 |
DFR2 (NRULE_0148) | Dihydrofolate reductase type 2 | |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | Caci_8421 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | Caci_8420 |
FOLC (NRULE_0160) | Bifunctional protein FolC | Caci_7289 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | |
GABA biosynthesis(NFUNC_0066) |
| Require | A | GAD (NRULE_0231) | Glutamate decarboxylase | Caci_8660 |
|---|
Gentamicin resistance(NFUNC_0053) |
| Require | A | ANT2 (NRULE_0153) | 2''-aminoglycoside nucleotidyltransferase | Caci_4744 |
|---|
| Participant | | AAC3 (NRULE_0149) | Aminoglycoside N(3')-acetyltransferase | Caci_0513 |
|---|
Human milk oligosaccharides metabolism(NFUNC_0083) |
| Require | A | LNBP (NRULE_0112) | 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase | |
|---|
| Participant | | NAHK (NRULE_0256) | N-acetylhexosamine 1-kinase | |
|---|
| | GALT (NRULE_0110) | Galactose-1-phosphate uridylyltransferase | Caci_7278 |
| | GALE (NRULE_0111) | UDP-glucose 4-epimerase | Caci_8174 Caci_1465 |
4-hydroxyphenylacetate degradation(NFUNC_0068) |
| Require | A | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
|---|
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| B | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| C | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | Caci_7867 Caci_8752 Caci_5960 Caci_3777 Caci_3558 Caci_2759 Caci_6495 Caci_6349 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| D | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | Caci_7867 Caci_8752 Caci_6349 Caci_2759 Caci_3558 Caci_5960 Caci_3777 Caci_6495 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| E | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | Caci_3777 Caci_2759 Caci_3558 Caci_6349 Caci_6495 Caci_7867 Caci_8752 Caci_5960 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| F | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | Caci_6495 Caci_6349 Caci_5960 Caci_3777 Caci_3558 Caci_2759 Caci_8752 Caci_7867 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| G | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
| H | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | |
Kanamycin resistance(NFUNC_0052) |
| Require | A | ANT4 (NRULE_0152) | Kanamycin nucleotidyltransferase | |
|---|
| B | ANT2 (NRULE_0153) | 2''-aminoglycoside nucleotidyltransferase | Caci_4744 |
| C | APH3 (NRULE_0156) | Aminoglycoside 3'-phosphotransferase | Caci_6179 |
| Participant | | AAC3 (NRULE_0149) | Aminoglycoside N(3')-acetyltransferase | Caci_0513 |
|---|
| | AAC6 (NRULE_0150) | Aminoglycoside N(6')-acetyltransferase | |
Macrolide antibiotic resistance(NFUNC_0045) |
| Require | A | ERM (NRULE_0164) | rRNA adenine N-6-methyltransferase | |
|---|
| B | RLMA (NRULE_0165) | 23S rRNA (guanine-N(1))-methyltransferase | Caci_1726 |
| C | MACA (NRULE_0166) | Macrolide-specific efflux protein MacA | |
MACB (NRULE_0167) | Macrolide export ATP-binding/permease protein MacB | |
| D | ERE (NRULE_0168) | Erythromycin esterase | Caci_3801 |
| E | MPH (NRULE_0169) | Macrolide 2'-phosphotransferase | |
| F | MGT (NRULE_0170) | Macrolide glycosyltransferase | |
Metal-binding protein(NFUNC_0105) |
| Require | A | MOP (NRULE_0322) | Putative molybdenum-binding protein | Caci_8653 Caci_1719 Caci_8651 |
|---|
| B | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | |
| C | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | Caci_2418 Caci_2151 Caci_2031 Caci_0910 Caci_2783 Caci_7421 Caci_7906 Caci_8652 |
| D | MNTR (NRULE_0327) | DtxR family transcriptional regulator MntR | |
| E | CUER (NRULE_0328) | Copper-responsive transcriptional regulator CueR | |
| F | SOXR (NRULE_0329) | Redox-sensitive transcriptional activator SoxR | |
| G | ZNTR (NRULE_0330) | Zinc-responsive transcriptional regulator ZntR | |
| H | NIKR (NRULE_0331) | Nickel-responsive transcriptional regulator NikR | |
| I | ISCR (NRULE_0332) | Rrf2 family transcriptional regulator IscR | |
| J | SMTA (NRULE_0009) | Metallothionein | Caci_2282 |
Metallothionein(NFUNC_0006) |
| Require | A | SMTA (NRULE_0009) | Metallothionein | Caci_2282 |
|---|
Molybdate transport (ABC transporter)(NFUNC_0097) |
| Require | A | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | Caci_2031 Caci_2418 Caci_2151 Caci_8652 Caci_7906 Caci_7421 Caci_2783 Caci_0910 |
|---|
| Participant | | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | |
|---|
| | MODB (NRULE_0325) | Molybdate ABC transporter permease protein | |
| | MODC (NRULE_0326) | Molybdate ABC transporter ATP-binding protein | |
Naphthalene degradation (via hydroxylation by dioxygenase)(NFUNC_0067) |
| Require | A | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | Caci_7447 |
|---|
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
EDIO (NRULE_0058) | extradiol dioxygenase | Caci_1819 |
NAHD (NRULE_0171) | 2-hydroxychromene-2-carboxylate isomerase | |
NAHE (NRULE_0172) | Trans-O-hydroxybenzylidenepyruvate hydratase-aldolase | |
NAHF (NRULE_0173) | Salicylaldehyde dehydrogenase | |
NAHG (NRULE_0190) | Salicylate hydroxylase | |
| B | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | Caci_7447 |
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
EDIO (NRULE_0058) | extradiol dioxygenase | Caci_1819 |
NAHD (NRULE_0171) | 2-hydroxychromene-2-carboxylate isomerase | |
NAHE (NRULE_0172) | Trans-O-hydroxybenzylidenepyruvate hydratase-aldolase | |
NAHF (NRULE_0173) | Salicylaldehyde dehydrogenase | |
NAGG (NRULE_0191) | Salicylate 5-hydroxylase alpha subunit | |
NAGH (NRULE_0192) | Salicylate 5-hydroxylase beta subunit | |
| Participant | | FDR1 (NRULE_0032) | Oxygenase electron transfer component | Caci_4894 Caci_3827 Caci_1748 |
|---|
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | Caci_4533 Caci_7447 Caci_5615 Caci_4400 Caci_0421 Caci_1679 Caci_2184 Caci_2265 Caci_2527 Caci_4332 Caci_4970 Caci_4895 Caci_0116 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | Caci_1305 Caci_2641 |
(R)-pantothenate biosynthesis(NFUNC_0030) |
| Require | A | PAND (NRULE_0115) | Aspartate 1-decarboxylase | Caci_8382 |
|---|
PANB (NRULE_0116) | 3-methyl-2-oxobutanoate hydroxymethyltransferase | Caci_1694 |
PANE (NRULE_0117) | 2-dehydropantoate 2-reductase | Caci_0833 Caci_4552 Caci_3116 |
PANC (NRULE_0118) | Pantothenate synthetase | Caci_8383 |
Penicillin resistance(NFUNC_0047) |
| Require | A | BLAA (NRULE_0122) | Beta-lactamase class A | Caci_5163 |
|---|
| B | BLAD (NRULE_0125) | Beta-lactamase class D | |
| Participant | | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
|---|
Phenol degradation(NFUNC_0028) |
| Require | A | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | |
|---|
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | |
MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
| B | PHEA1 (NRULE_0083) | Aromatic ring hydroxylase | |
| C | PHEA2 (NRULE_0084) | Aromatic ring hydroxylase | |
| Participant | | FDR2 (NRULE_0057) | Ferredoxin reductase | Caci_2641 Caci_1305 |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | Caci_1748 Caci_3827 Caci_4894 |
| | MME (NRULE_0033) | Multicomponent monooxygenase effector protein | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | Caci_4970 Caci_0116 Caci_0421 Caci_1679 Caci_2184 Caci_2265 Caci_2527 Caci_4332 Caci_4400 Caci_4533 Caci_7447 Caci_4895 Caci_5615 |
| | FADR1 (NRULE_0101) | NADH-dependent flavin reductase | Caci_5960 Caci_3558 Caci_3777 Caci_6495 Caci_6349 Caci_2759 Caci_8752 Caci_7867 |
Protocatechuate degradation (beta-ketoadipate pathway)(NFUNC_0014) |
| Require | A | PCAG (NRULE_0066) | Protocatechuate 3,4-dioxygenase alpha subunit | Caci_4889 |
|---|
PCAH (NRULE_0067) | Protocatechuate 3,4-dioxygenase beta subunit | Caci_4890 |
PCAB (NRULE_0068) | 3-carboxy-cis,cis-muconate cycloisomerase | |
PCAC (NRULE_0069) | 4-carboxymuconolactone decarboxylase | Caci_4887 |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | Caci_4887 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | Caci_4338 Caci_4892 Caci_7914 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | Caci_4891 Caci_7913 Caci_4339 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | Caci_6183 |
| B | PCAG (NRULE_0066) | Protocatechuate 3,4-dioxygenase alpha subunit | Caci_4889 |
PCAH (NRULE_0067) | Protocatechuate 3,4-dioxygenase beta subunit | Caci_4890 |
PCAB (NRULE_0068) | 3-carboxy-cis,cis-muconate cycloisomerase | |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | Caci_4887 |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | Caci_4338 Caci_7914 Caci_4892 |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | Caci_4891 Caci_7913 Caci_4339 |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | Caci_6183 |
Riboflavin biosynthesis(NFUNC_0058) |
| Require | A | RIBB (NRULE_0200) | 3,4-dihydroxy-2-butanone 4-phosphate synthase | Caci_3108 |
|---|
RIBA (NRULE_0201) | GTP cyclohydrolase-2 | Caci_3108 Caci_1820 Caci_3851 |
RIBD (NRULE_0202) | Riboflavin biosynthesis protein RibD | |
RIBH (NRULE_0203) | 6,7-dimethyl-8-ribityllumazine synthase | Caci_3109 |
RIBE (NRULE_0204) | Riboflavin synthase | Caci_3107 |
| Participant | | RIBF (NRULE_0205) | Riboflavin biosynthesis protein RibF | Caci_7738 |
|---|
Streptomycin resistance(NFUNC_0054) |
| Require | A | ANT6 (NRULE_0151) | Aminoglycoside 6-adenylyltransferase | |
|---|
| B | ANT3 (NRULE_0154) | Streptomycin 3''-adenylyltransferase | |
| C | APH6 (NRULE_0155) | Streptomycin 6-kinase | |
| Participant | | APH3 (NRULE_0156) | Aminoglycoside 3'-phosphotransferase | Caci_6179 |
|---|
Toluene degradation (conversion into benzoate)(NFUNC_0009) |
| Require | A | XYLA (NRULE_0025) | Xylene monooxygenase electron transfer component | |
|---|
XYLM (NRULE_0026) | Xylene monooxygenase | |
BADH (NRULE_0042) | Aryl-alcohol dehydrogenase | |
BZDH1 (NRULE_0043) | Benzaldehyde dehydrogenase | Caci_2625 Caci_4885 |
| B | XYLA (NRULE_0025) | Xylene monooxygenase electron transfer component | |
XYLM (NRULE_0026) | Xylene monooxygenase | |
BADH (NRULE_0042) | Aryl-alcohol dehydrogenase | |
BZDH2 (NRULE_0381) | NAD(P)-dependent benzaldehyde dehydrogenase | |
Toluene degradation (conversion into protocatechuate via p-cresol)(NFUNC_0007) |
| Require | A | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | |
|---|
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | |
FDR1 (NRULE_0032) | Oxygenase electron transfer component | Caci_1748 Caci_3827 Caci_4894 |
MME (NRULE_0033) | Multicomponent monooxygenase effector protein | |
PCHF (NRULE_0035) | 4-cresol dehydrogenase flavoprotein subunit | |
PCHC (NRULE_0036) | 4-cresol dehydrogenase cytochrome c subunit | |
PCHA (NRULE_0037) | p-hydroxybenzaldehyde dehydrogenase | |
POBA (NRULE_0038) | p-hydroxybenzoate hydroxylase | |
| Participant | | MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
|---|
| | MMG2 (NRULE_0030) | Multicomponent monooxygenase gamma subunit | |
| | MMG3 (NRULE_0031) | Multicomponent monooxygenase gamma subunit | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | Caci_7447 Caci_5615 Caci_4970 Caci_0116 Caci_0421 Caci_1679 Caci_2184 Caci_2265 Caci_2527 Caci_4332 Caci_4400 Caci_4533 Caci_4895 |
Trehalose biosynthesis (from NDP-glucose and glucose-6-phosphate)(NFUNC_0031) |
| Require | A | TPS (NRULE_0119) | Trehalose-phosphate synthase | Caci_2546 Caci_2644 Caci_3724 |
|---|
TPP (NRULE_0120) | Trehalose-6-phosphate phosphatase | Caci_4324 Caci_3711 |
Vancomycin resistance (via D-Ala-D-Lac precursor)(NFUNC_0089) |
| Require | A | VANA (NRULE_0265) | D-alanine--D-lactate ligase | Caci_5793 |
|---|
VANH (NRULE_0266) | D-specific alpha-keto acid dehydrogenase | Caci_5794 |
VANX (NRULE_0267) | D-alanyl-D-alanine dipeptidase | Caci_5792 |
| Participant | | VANYA (NRULE_0274) | D-alanyl-D-alanine carboxypeptidase | |
|---|
| | VANYB (NRULE_0275) | D-alanyl-D-alanine carboxypeptidase | |
| | VANYD (NRULE_0276) | D-alanyl-D-alanine carboxypeptidase | |
| | VANY (NRULE_0277) | D-alanyl-D-alanine carboxypeptidase | |
| | VANYN (NRULE_0278) | D-alanyl-D-alanine dipeptidase/D-alanyl-D-alanine carboxypeptidase | |
| | VANRA (NRULE_0279) | Two-component system response regulator VanR | |
| | VANRB (NRULE_0280) | Two-component system response regulator VanR | |
| | VANRD (NRULE_0282) | Putative two-component system response regulator VanR | |
| | VANR (NRULE_0284) | Two-component system response regulator VanR | Caci_5788 |
| | VANSA (NRULE_0285) | Two-component system histidine kinase VanS | |
| | VANSB (NRULE_0286) | Two-component system histidine kinase VanS | |
| | VANSD (NRULE_0288) | Putative two-component system histidine kinase VanS | |
| | VANSM (NRULE_0289) | Putative two-component system histidine kinase VanS | |
| | VANS (NRULE_0290) | Two-component system histidine kinase VanS | Caci_5789 |
| | VANZ (NRULE_0291) | Teicoplanin resistance protein | |
| | VANW (NRULE_0292) | Putative vancomycin resistance protein | |
| | VANJ (NRULE_0295) | Teicoplanin resistance protein | |
| | VANK (NRULE_0296) | Glycyltransferase VanK | |
| | MURF2 (NRULE_0297) | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-lactate ligase | |
Vitamin B6 biosynthesis (PdxS/PdxT pathway)(NFUNC_0059) |
| Require | A | PDXS (NRULE_0206) | Pyridoxal biosynthesis lyase PdxS | Caci_2349 |
|---|
PDXT (NRULE_0207) | Glutamine amidotransferase subunit PdxT | Caci_2350 |
