Alanine racemization(NFUNC_0063) |
| 必須 | A | ALR (NRULE_0228) | Alanine racemase | HMPREF9086_2156 HMPREF9086_2738 |
|---|
n-alkane hydroxylation(NFUNC_0008) |
| 必須 | A | CYP153 (NRULE_0041) | Cytochrome P450 CYP153 | |
|---|
| B | ALKB (NRULE_0024) | Alkane 1-monooxygenase | |
| C | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | |
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | |
FDR1 (NRULE_0032) | Oxygenase electron transfer component | HMPREF9086_1610 HMPREF9086_0952 HMPREF9086_0308 |
MME (NRULE_0033) | Multicomponent monooxygenase effector protein | |
| 任意 | | RUBA (NRULE_0039) | Rubredoxin | HMPREF9086_3589 |
|---|
| | RUBB (NRULE_0040) | Rubredoxin reductase | |
| | MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
| | MMG2 (NRULE_0030) | Multicomponent monooxygenase gamma subunit | |
| | MMG3 (NRULE_0031) | Multicomponent monooxygenase gamma subunit | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | HMPREF9086_3799 HMPREF9086_3801 |
Aniline degradation (conversion into catechol)(NFUNC_0075) |
| 必須 | A | ATDA1 (NRULE_0240) | Gamma-glutamylanilide synthetase | |
|---|
ATDA3 (NRULE_0357) | Aniline dioxygenase large subunit | |
ATDA4 (NRULE_0358) | Aniline dioxygenase small subunit | |
| 任意 | | ATDA2 (NRULE_0241) | Putative gamma-glutamylanilide hydrolase | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | HMPREF9086_0308 HMPREF9086_1610 HMPREF9086_0952 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | HMPREF9086_3799 HMPREF9086_3801 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | |
Anthranilate biosynthesis(NFUNC_0038) |
| 必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | HMPREF9086_2616 HMPREF9086_4208 |
|---|
TRPE (NRULE_0143) | Anthranilate synthase component I | HMPREF9086_2615 |
Anthranilate degradation (via hydroxylation)(NFUNC_0018) |
| 必須 | A | ANTA (NRULE_0044) | Anthranilate 1,2-dioxygenase large subunit | |
|---|
ANTB (NRULE_0045) | Anthranilate 1,2-dioxygenase small subunit | |
| 任意 | | ANTC (NRULE_0081) | Anthranilate 1,2-dioxygenase electron transfer component | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | HMPREF9086_0952 HMPREF9086_0308 HMPREF9086_1610 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | HMPREF9086_3799 HMPREF9086_3801 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | |
Aromatic azo compounds degradation(NFUNC_0073) |
| 必須 | A | AZOR (NRULE_0236) | FMN-dependent NADH-azoreductase | HMPREF9086_2280 |
|---|
| B | AZR (NRULE_0237) | NADPH azoreductase | |
| C | AZOB (NRULE_0238) | NAD(P)H azoreductase | |
Aromatic hydrocarbon degradation (via hydroxylation by dioxygenase)(NFUNC_0016) |
| 必須 | A | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | |
|---|
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
| 任意 | | FDR1 (NRULE_0032) | Oxygenase electron transfer component | HMPREF9086_0308 HMPREF9086_0952 HMPREF9086_1610 |
|---|
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | HMPREF9086_3799 HMPREF9086_3801 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | |
Arsenical resistance(NFUNC_0004) |
| 必須 | A | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | HMPREF9086_2609 |
|---|
ARSC1 (NRULE_0017) | Arsenate reductase | HMPREF9086_3318 HMPREF9086_2608 HMPREF9086_1004 |
| B | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | HMPREF9086_2609 |
ARSC2 (NRULE_0018) | Arsenate reductase | |
| C | ARSB1 (NRULE_0015) | Arsenical pump membrane protein | HMPREF9086_2609 |
ARSC3 (NRULE_0019) | Arsenate reductase | |
| D | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | |
ARSC1 (NRULE_0017) | Arsenate reductase | HMPREF9086_3318 HMPREF9086_2608 HMPREF9086_1004 |
| E | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | |
ARSC2 (NRULE_0018) | Arsenate reductase | |
| F | ARSB2 (NRULE_0016) | Arsenite resistance protein ArsB | |
ARSC3 (NRULE_0019) | Arsenate reductase | |
| 任意 | | ARSA (NRULE_0014) | Arsenical pump-driving ATPase | |
|---|
| | ARSD (NRULE_0020) | Arsenical resistance operon trans-acting repressor ArsD | |
| | ARSH (NRULE_0021) | ArsH protein | HMPREF9086_2611 |
Artificial lacto-N-biose biosynthesis(NFUNC_0026) |
| 必須 | A | SP (NRULE_0109) | Sucrose phosphorylase | |
|---|
GALT (NRULE_0110) | Galactose-1-phosphate uridylyltransferase | HMPREF9086_1103 |
GALE (NRULE_0111) | UDP-glucose 4-epimerase | HMPREF9086_3020 HMPREF9086_1102 |
LNBP (NRULE_0112) | 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase | |
Bacitracin resistance(NFUNC_0022) |
| 必須 | A | UPPP (NRULE_0097) | Undecaprenyl-diphosphatase | HMPREF9086_3896 |
|---|
Benzoate degradation (via hydroxylation by dioxygenase)(NFUNC_0017) |
| 必須 | A | BENA (NRULE_0046) | Benzoate 1,2-dioxygenase alpha subunit | |
|---|
BENB (NRULE_0047) | Benzoate 1,2-dioxygenase beta subunit | |
BEND (NRULE_0082) | 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase | |
| 任意 | | BENC (NRULE_0055) | Benzoate 1,2-dioxygenase electron transfer component | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | HMPREF9086_0952 HMPREF9086_1610 HMPREF9086_0308 |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | HMPREF9086_3799 HMPREF9086_3801 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | |
Beta-lactam antibiotic resistance(NFUNC_0033) |
| 必須 | A | BLAA (NRULE_0122) | Beta-lactamase class A | |
|---|
| B | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
| C | BLAC (NRULE_0124) | Beta-lactamase class C | HMPREF9086_2076 |
| D | BLAD (NRULE_0125) | Beta-lactamase class D | |
Betaine biosynthesis (from choline)(NFUNC_0049) |
| 必須 | A | BETA (NRULE_0175) | Choline dehydrogenase | HMPREF9086_1260 |
|---|
| B | GBSB (NRULE_0176) | Alcohol dehydrogenase | |
BETB (NRULE_0177) | Betaine aldehyde dehydrogenase | HMPREF9086_1259 |
| C | CHOX (NRULE_0178) | Choline oxidase | |
Biotin biosynthesis(NFUNC_0051) |
| 必須 | A | BIOF (NRULE_0182) | 8-amino-7-oxononanoate synthase | HMPREF9086_1084 |
|---|
BIOA (NRULE_0183) | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | HMPREF9086_1086 |
BIOD (NRULE_0184) | ATP-dependent dethiobiotin synthetase BioD | HMPREF9086_0368 HMPREF9086_1082 |
BIOB (NRULE_0185) | Biotin synthase | HMPREF9086_1085 |
Catechol degradation (beta-ketoadipate pathway)(NFUNC_0013) |
| 必須 | A | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | |
|---|
CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | |
CATC (NRULE_0054) | Muconolactone isomerase | |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | HMPREF9086_0303 |
| B | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | |
CATC (NRULE_0054) | Muconolactone isomerase | |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | HMPREF9086_0303 |
CATB1 (NRULE_0386) | Muconate cycloisomerase | |
| C | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | |
CATC (NRULE_0054) | Muconolactone isomerase | |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | HMPREF9086_0303 |
CATB1 (NRULE_0386) | Muconate cycloisomerase | |
| D | CATA (NRULE_0052) | Catechol 1,2-dioxygenase | |
CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | |
CATC (NRULE_0054) | Muconolactone isomerase | |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | HMPREF9086_0303 |
Cephalosporin resistance(NFUNC_0048) |
| 必須 | A | BLAC (NRULE_0124) | Beta-lactamase class C | HMPREF9086_2076 |
|---|
| 任意 | | BLAA (NRULE_0122) | Beta-lactamase class A | |
|---|
| | BLAB (NRULE_0123) | Metallo-beta-lactamase | |
Chloramphenicol resistance(NFUNC_0025) |
| 必須 | A | CAT1 (NRULE_0107) | Chloramphenicol acetyltransferase | HMPREF9086_0356 |
|---|
| B | CAT4 (NRULE_0108) | Chloramphenicol acetyltransferase | |
Chlorocatechol degradation (beta-ketoadipate pathway)(NFUNC_0104) |
| 必須 | A | PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
|---|
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | HMPREF9086_0303 |
CLCA (NRULE_0382) | Chlorocatechol 1,2-dioxygenase | |
CLCD (NRULE_0383) | Dienelactone hydrolase | HMPREF9086_1929 HMPREF9086_2044 HMPREF9086_3308 HMPREF9086_0358 HMPREF9086_4364 |
CLCE (NRULE_0384) | Maleylacetate reductase | |
CLCB (NRULE_0387) | Chloromuconate cycloisomerase | |
| B | CATB2 (NRULE_0053) | (Chloro)muconate cycloisomerase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | HMPREF9086_0303 |
CLCA (NRULE_0382) | Chlorocatechol 1,2-dioxygenase | |
CLCD (NRULE_0383) | Dienelactone hydrolase | HMPREF9086_2044 HMPREF9086_1929 HMPREF9086_0358 HMPREF9086_3308 HMPREF9086_4364 |
CLCE (NRULE_0384) | Maleylacetate reductase | |
| 任意 | | CLCF (NRULE_0385) | Chloromuconolactone dehalogenase | |
|---|
Dibenzothiophene degradation (via desulfurization)(NFUNC_0029) |
| 必須 | A | DSZA (NRULE_0103) | Dibenzothiophene-5,5-dioxide monooxygenase | |
|---|
DSZB (NRULE_0104) | 2'-hydroxybiphenyl-2-sulfinate desulfinase | |
DSZC (NRULE_0105) | Dibenzothiophene monooxygenase | |
| 任意 | | FADR1 (NRULE_0101) | NADH-dependent flavin reductase | HMPREF9086_1895 HMPREF9086_0843 HMPREF9086_1214 HMPREF9086_2461 |
|---|
Dihydroxy aromatic compounds degradation (via meta-cleavage pathway)(NFUNC_0011) |
| 必須 | A | EDIO (NRULE_0058) | extradiol dioxygenase | HMPREF9086_1888 HMPREF9086_3882 |
|---|
METAH (NRULE_0059) | meta-cleavage compound hydrolase | |
HPDH (NRULE_0063) | 2-hydroxypent-2,4-dienoate hydratase | |
HOA (NRULE_0064) | 4-hydroxy-2-oxovalerate aldolase | |
ACDH (NRULE_0065) | Acetaldehyde dehydrogenase | |
| B | EDIO (NRULE_0058) | extradiol dioxygenase | HMPREF9086_1888 HMPREF9086_3882 |
2HMSD (NRULE_0060) | 2-hydroxymuconic semialdehyde dehydrogenase | |
4OT (NRULE_0061) | 4-oxalocrotonate tautomerase | |
4OD (NRULE_0062) | 4-oxalocrotonate decarboxylase | |
HPDH (NRULE_0063) | 2-hydroxypent-2,4-dienoate hydratase | |
HOA (NRULE_0064) | 4-hydroxy-2-oxovalerate aldolase | |
ACDH (NRULE_0065) | Acetaldehyde dehydrogenase | |
Folate biosynthesis(NFUNC_0044) |
| 必須 | A | GLAT (NRULE_0142) | Glutamine amidotransferase | HMPREF9086_2616 HMPREF9086_4208 |
|---|
DHPS (NRULE_0144) | Dihydropteroate synthase | HMPREF9086_4036 |
FOLM (NRULE_0146) | Dihydrofolate reductase FolM | HMPREF9086_0413 |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | HMPREF9086_3219 HMPREF9086_3897 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | HMPREF9086_1687 |
FOLC (NRULE_0160) | Bifunctional protein FolC | HMPREF9086_3231 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | HMPREF9086_2757 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | HMPREF9086_0761 |
| B | GLAT (NRULE_0142) | Glutamine amidotransferase | HMPREF9086_4208 HMPREF9086_2616 |
DHPS (NRULE_0144) | Dihydropteroate synthase | HMPREF9086_4036 |
FOLA (NRULE_0147) | Dihydrofolate reductase | HMPREF9086_1783 HMPREF9086_4599 |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | HMPREF9086_3219 HMPREF9086_3897 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | HMPREF9086_1687 |
FOLC (NRULE_0160) | Bifunctional protein FolC | HMPREF9086_3231 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | HMPREF9086_2757 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | HMPREF9086_0761 |
| C | GLAT (NRULE_0142) | Glutamine amidotransferase | HMPREF9086_4208 HMPREF9086_2616 |
DHPS (NRULE_0144) | Dihydropteroate synthase | HMPREF9086_4036 |
DFR2 (NRULE_0148) | Dihydrofolate reductase type 2 | |
FOLB (NRULE_0158) | Dihydroneopterin aldolase | HMPREF9086_3219 HMPREF9086_3897 |
FOLK (NRULE_0159) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | HMPREF9086_1687 |
FOLC (NRULE_0160) | Bifunctional protein FolC | HMPREF9086_3231 |
PABB (NRULE_0161) | Para-aminobenzoate synthase component I | HMPREF9086_2757 |
PABC (NRULE_0162) | Aminodeoxychorismate lyase | HMPREF9086_0761 |
Human milk oligosaccharides metabolism(NFUNC_0083) |
| 必須 | A | LNBP (NRULE_0112) | 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase | |
|---|
| 任意 | | NAHK (NRULE_0256) | N-acetylhexosamine 1-kinase | |
|---|
| | GALT (NRULE_0110) | Galactose-1-phosphate uridylyltransferase | HMPREF9086_1103 |
| | GALE (NRULE_0111) | UDP-glucose 4-epimerase | HMPREF9086_3020 HMPREF9086_1102 |
4-hydroxyphenylacetate degradation(NFUNC_0068) |
| 必須 | A | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | HMPREF9086_1894 |
|---|
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | HMPREF9086_1895 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | HMPREF9086_1888 |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | HMPREF9086_1887 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | HMPREF9086_1889 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | HMPREF9086_1886 |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | HMPREF9086_1890 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | HMPREF9086_1891 |
| B | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | HMPREF9086_1894 |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | HMPREF9086_1895 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | HMPREF9086_1887 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | HMPREF9086_1889 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | HMPREF9086_1886 |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | HMPREF9086_1890 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | HMPREF9086_1891 |
| C | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | HMPREF9086_1894 |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | HMPREF9086_1214 HMPREF9086_1895 HMPREF9086_2461 HMPREF9086_0843 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | HMPREF9086_1888 |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | HMPREF9086_1887 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | HMPREF9086_1889 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | HMPREF9086_1886 |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | HMPREF9086_1890 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | HMPREF9086_1891 |
| D | HPAB1 (NRULE_0085) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | HMPREF9086_1894 |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | HMPREF9086_2461 HMPREF9086_1214 HMPREF9086_0843 HMPREF9086_1895 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | HMPREF9086_1887 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | HMPREF9086_1889 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | HMPREF9086_1886 |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | HMPREF9086_1890 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | HMPREF9086_1891 |
| E | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | HMPREF9086_1895 HMPREF9086_1214 HMPREF9086_2461 HMPREF9086_0843 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | HMPREF9086_1887 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | HMPREF9086_1889 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | HMPREF9086_1886 |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | HMPREF9086_1890 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | HMPREF9086_1891 |
| F | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
FADR1 (NRULE_0101) | NADH-dependent flavin reductase | HMPREF9086_1895 HMPREF9086_2461 HMPREF9086_0843 HMPREF9086_1214 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | HMPREF9086_1888 |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | HMPREF9086_1887 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | HMPREF9086_1889 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | HMPREF9086_1886 |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | HMPREF9086_1890 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | HMPREF9086_1891 |
| G | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | HMPREF9086_1895 |
HPAD2 (NRULE_0194) | Homoprotocatechuate 2,3-dioxygenase | |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | HMPREF9086_1887 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | HMPREF9086_1889 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | HMPREF9086_1886 |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | HMPREF9086_1890 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | HMPREF9086_1891 |
| H | HPAB2 (NRULE_0086) | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | |
HPAC (NRULE_0102) | 4-hydroxyphenylacetate 3-monooxygenase reductase component | HMPREF9086_1895 |
HPAD1 (NRULE_0193) | Homoprotocatechuate 2,3-dioxygenase | HMPREF9086_1888 |
HPAE (NRULE_0195) | 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase | HMPREF9086_1887 |
HPAF (NRULE_0196) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | HMPREF9086_1889 |
HPAG (NRULE_0197) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase | HMPREF9086_1886 |
HPAH (NRULE_0198) | 2-oxo-hepta-3-ene-1,7-dioate hydratase | HMPREF9086_1890 |
HPAI (NRULE_0199) | 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase | HMPREF9086_1891 |
Macrolide antibiotic resistance(NFUNC_0045) |
| 必須 | A | ERM (NRULE_0164) | rRNA adenine N-6-methyltransferase | |
|---|
| B | RLMA (NRULE_0165) | 23S rRNA (guanine-N(1))-methyltransferase | HMPREF9086_2767 |
| C | MACA (NRULE_0166) | Macrolide-specific efflux protein MacA | HMPREF9086_0946 |
MACB (NRULE_0167) | Macrolide export ATP-binding/permease protein MacB | HMPREF9086_0945 |
| D | ERE (NRULE_0168) | Erythromycin esterase | |
| E | MPH (NRULE_0169) | Macrolide 2'-phosphotransferase | |
| F | MGT (NRULE_0170) | Macrolide glycosyltransferase | |
Metal-binding protein(NFUNC_0105) |
| 必須 | A | MOP (NRULE_0322) | Putative molybdenum-binding protein | HMPREF9086_1100 HMPREF9086_3523 HMPREF9086_1096 |
|---|
| B | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | HMPREF9086_1100 |
| C | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | HMPREF9086_1098 HMPREF9086_3290 HMPREF9086_0130 HMPREF9086_2978 |
| D | MNTR (NRULE_0327) | DtxR family transcriptional regulator MntR | |
| E | CUER (NRULE_0328) | Copper-responsive transcriptional regulator CueR | HMPREF9086_1403 |
| F | SOXR (NRULE_0329) | Redox-sensitive transcriptional activator SoxR | HMPREF9086_2146 |
| G | ZNTR (NRULE_0330) | Zinc-responsive transcriptional regulator ZntR | HMPREF9086_4145 |
| H | NIKR (NRULE_0331) | Nickel-responsive transcriptional regulator NikR | |
| I | ISCR (NRULE_0332) | Rrf2 family transcriptional regulator IscR | HMPREF9086_3389 |
| J | SMTA (NRULE_0009) | Metallothionein | |
Molybdate transport (ABC transporter)(NFUNC_0097) |
| 必須 | A | MODA (NRULE_0324) | Molybdate ABC transporter substrate-binding protein | HMPREF9086_2978 HMPREF9086_3290 HMPREF9086_1098 HMPREF9086_0130 |
|---|
| 任意 | | MODE (NRULE_0323) | Putative molybdate-dependent transcriptional regulator | HMPREF9086_1100 |
|---|
| | MODB (NRULE_0325) | Molybdate ABC transporter permease protein | HMPREF9086_1097 |
| | MODC (NRULE_0326) | Molybdate ABC transporter ATP-binding protein | HMPREF9086_1096 |
Mycosamine biosynthesis(NFUNC_0095) |
| 必須 | A | AMPHDII (NRULE_0342) | GDP-3-keto-6-deoxy-D-mannose C-3 aminotransferase | |
|---|
GMD (NRULE_0343) | GDP-mannose 4,6-dehydratase | HMPREF9086_3040 |
| 任意 | | AMPHDI (NRULE_0341) | GDP-mycosamine glycosyltransferase | |
|---|
Naphthalene degradation (via hydroxylation by dioxygenase)(NFUNC_0067) |
| 必須 | A | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | |
|---|
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
EDIO (NRULE_0058) | extradiol dioxygenase | HMPREF9086_3882 HMPREF9086_1888 |
NAHD (NRULE_0171) | 2-hydroxychromene-2-carboxylate isomerase | |
NAHE (NRULE_0172) | Trans-O-hydroxybenzylidenepyruvate hydratase-aldolase | |
NAHF (NRULE_0173) | Salicylaldehyde dehydrogenase | |
NAHG (NRULE_0190) | Salicylate hydroxylase | |
| B | RHDA (NRULE_0048) | Ring-hydroxylating dioxygenase alpha subunit | |
RHDB (NRULE_0049) | Ring-hydroxylating dioxygenase beta subunit | |
CDDH (NRULE_0056) | Cis-dihydrodiol dehydrogenase | |
EDIO (NRULE_0058) | extradiol dioxygenase | HMPREF9086_1888 HMPREF9086_3882 |
NAHD (NRULE_0171) | 2-hydroxychromene-2-carboxylate isomerase | |
NAHE (NRULE_0172) | Trans-O-hydroxybenzylidenepyruvate hydratase-aldolase | |
NAHF (NRULE_0173) | Salicylaldehyde dehydrogenase | |
NAGG (NRULE_0191) | Salicylate 5-hydroxylase alpha subunit | |
NAGH (NRULE_0192) | Salicylate 5-hydroxylase beta subunit | |
| 任意 | | FDR1 (NRULE_0032) | Oxygenase electron transfer component | HMPREF9086_0308 HMPREF9086_1610 HMPREF9086_0952 |
|---|
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | HMPREF9086_3799 HMPREF9086_3801 |
| | FDR2 (NRULE_0057) | Ferredoxin reductase | |
Nitrile hydratase(NFUNC_0002) |
| 必須 | A | NHAA (NRULE_0001) | Nitrile hydratase subunit alpha | |
|---|
NHAB (NRULE_0002) | Nitrile hydratase subunit beta | |
| 任意 | | P14K (NRULE_0006) | Nitrile hydratase activator P14K | |
|---|
| | COBW (NRULE_0007) | CobW/P47K family protein | HMPREF9086_1898 HMPREF9086_3127 |
(R)-pantothenate biosynthesis(NFUNC_0030) |
| 必須 | A | PAND (NRULE_0115) | Aspartate 1-decarboxylase | HMPREF9086_1690 |
|---|
PANB (NRULE_0116) | 3-methyl-2-oxobutanoate hydroxymethyltransferase | HMPREF9086_1688 |
PANE (NRULE_0117) | 2-dehydropantoate 2-reductase | HMPREF9086_1275 HMPREF9086_1480 |
PANC (NRULE_0118) | Pantothenate synthetase | HMPREF9086_1689 |
Phenol degradation(NFUNC_0028) |
| 必須 | A | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | |
|---|
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | |
MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
| B | PHEA1 (NRULE_0083) | Aromatic ring hydroxylase | HMPREF9086_1894 |
| C | PHEA2 (NRULE_0084) | Aromatic ring hydroxylase | |
| 任意 | | FDR2 (NRULE_0057) | Ferredoxin reductase | |
|---|
| | FDR1 (NRULE_0032) | Oxygenase electron transfer component | HMPREF9086_0308 HMPREF9086_1610 HMPREF9086_0952 |
| | MME (NRULE_0033) | Multicomponent monooxygenase effector protein | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | HMPREF9086_3801 HMPREF9086_3799 |
| | FADR1 (NRULE_0101) | NADH-dependent flavin reductase | HMPREF9086_1214 HMPREF9086_2461 HMPREF9086_1895 HMPREF9086_0843 |
Protocatechuate degradation (beta-ketoadipate pathway)(NFUNC_0014) |
| 必須 | A | PCAG (NRULE_0066) | Protocatechuate 3,4-dioxygenase alpha subunit | |
|---|
PCAH (NRULE_0067) | Protocatechuate 3,4-dioxygenase beta subunit | |
PCAB (NRULE_0068) | 3-carboxy-cis,cis-muconate cycloisomerase | |
PCAC (NRULE_0069) | 4-carboxymuconolactone decarboxylase | |
PCAD (NRULE_0070) | 3-oxoadipate enol-lactonase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | HMPREF9086_0303 |
| B | PCAG (NRULE_0066) | Protocatechuate 3,4-dioxygenase alpha subunit | |
PCAH (NRULE_0067) | Protocatechuate 3,4-dioxygenase beta subunit | |
PCAB (NRULE_0068) | 3-carboxy-cis,cis-muconate cycloisomerase | |
PCAL (NRULE_0071) | 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase | |
PCAI (NRULE_0072) | 3-oxoadipate CoA-transferase subunit A | |
PCAJ (NRULE_0073) | 3-oxoadipate CoA-transferase subunit B | |
PCAF (NRULE_0074) | Beta-ketoadipyl-CoA thiolase | HMPREF9086_0303 |
Pyrroloquinoline quinone biosynthesis(NFUNC_0020) |
| 必須 | A | PQQC (NRULE_0092) | Pyrroloquinoline-quinone synthase | HMPREF9086_0390 |
|---|
| 任意 | | PQQA (NRULE_0090) | Coenzyme PQQ synthesis protein A | |
|---|
| | PQQB (NRULE_0091) | Coenzyme PQQ synthesis protein B | HMPREF9086_0389 |
| | PQQD (NRULE_0093) | Coenzyme PQQ synthesis protein D | HMPREF9086_0391 |
| | PQQE (NRULE_0094) | Coenzyme PQQ synthesis protein E | HMPREF9086_0392 |
| | PQQF (NRULE_0095) | Coenzyme PQQ synthesis protein F | HMPREF9086_0393 |
Riboflavin biosynthesis(NFUNC_0058) |
| 必須 | A | RIBB (NRULE_0200) | 3,4-dihydroxy-2-butanone 4-phosphate synthase | HMPREF9086_3889 |
|---|
RIBA (NRULE_0201) | GTP cyclohydrolase-2 | HMPREF9086_2588 |
RIBD (NRULE_0202) | Riboflavin biosynthesis protein RibD | HMPREF9086_1490 |
RIBH (NRULE_0203) | 6,7-dimethyl-8-ribityllumazine synthase | HMPREF9086_1591 HMPREF9086_1489 |
RIBE (NRULE_0204) | Riboflavin synthase | HMPREF9086_0516 |
| 任意 | | RIBF (NRULE_0205) | Riboflavin biosynthesis protein RibF | HMPREF9086_1805 |
|---|
Toluene degradation (conversion into protocatechuate via p-cresol)(NFUNC_0007) |
| 必須 | A | MMA (NRULE_0027) | Multicomponent monooxygenase alpha subunit | |
|---|
MMB (NRULE_0028) | Multicomponent monooxygenase beta subunit | |
FDR1 (NRULE_0032) | Oxygenase electron transfer component | HMPREF9086_0952 HMPREF9086_0308 HMPREF9086_1610 |
MME (NRULE_0033) | Multicomponent monooxygenase effector protein | |
PCHF (NRULE_0035) | 4-cresol dehydrogenase flavoprotein subunit | |
PCHC (NRULE_0036) | 4-cresol dehydrogenase cytochrome c subunit | |
PCHA (NRULE_0037) | p-hydroxybenzaldehyde dehydrogenase | |
POBA (NRULE_0038) | p-hydroxybenzoate hydroxylase | |
| 任意 | | MMG1 (NRULE_0029) | Multicomponent monooxygenase gamma subunit | |
|---|
| | MMG2 (NRULE_0030) | Multicomponent monooxygenase gamma subunit | |
| | MMG3 (NRULE_0031) | Multicomponent monooxygenase gamma subunit | |
| | FDX1 (NRULE_0034) | Putative Rieske-type ferredoxin | HMPREF9086_3799 HMPREF9086_3801 |
Trehalose biosynthesis (from maltooligosaccharide)(NFUNC_0037) |
| 必須 | A | TREY (NRULE_0140) | Maltooligosyl trehalose synthase | HMPREF9086_2407 |
|---|
TREZ (NRULE_0141) | Malto-oligosyltrehalose trehalohydrolase | HMPREF9086_2408 |
| 任意 | | GLGX (NRULE_0139) | Glycogen debranching enzyme | HMPREF9086_2406 HMPREF9086_4261 |
|---|
Trehalose biosynthesis (from NDP-glucose and glucose-6-phosphate)(NFUNC_0031) |
| 必須 | A | TPS (NRULE_0119) | Trehalose-phosphate synthase | HMPREF9086_2897 |
|---|
TPP (NRULE_0120) | Trehalose-6-phosphate phosphatase | HMPREF9086_2898 |
Uptake of osmoprotectant(NFUNC_0061) |
| 必須 | A | OPUAC (NRULE_0213) | Osmoprotectant ABC transporter substrate-binding protein | HMPREF9086_3565 |
|---|
OPUAB (NRULE_0214) | Osmoprotectant ABC transporter permease protein | HMPREF9086_3564 |
OPUAA (NRULE_0215) | Osmoprotectant ABC transporter ATP-binding protein | HMPREF9086_3563 HMPREF9086_0364 |
| B | EHUB (NRULE_0216) | Ectoine ABC transporter substrate-binding protein | |
EHUC (NRULE_0217) | Ectoine ABC transporter permease protein | |
EHUD (NRULE_0218) | Ectoine ABC transporter permease protein | |
EHUA (NRULE_0219) | Ectoine ABC transporter ATP-binding protein | |
| C | BCCT (NRULE_0220) | BCCT family transporter | HMPREF9086_2262 HMPREF9086_1257 |
| D | PROP (NRULE_0221) | Osmoprotectant transporter | HMPREF9086_2102 |
| E | OPUE (NRULE_0222) | Sodium/proline symporter | HMPREF9086_0834 |
| F | TEAA (NRULE_0223) | TRAP transporter substrate-binding protein TeaA | |
TEAB (NRULE_0224) | TRAP transporter small transmembrane protein TeaB | |
TEAC (NRULE_0225) | TRAP transporter large transmembrane protein TeaC | |
Vitamin B6 biosynthesis (PdxA/PdxJ pathway)(NFUNC_0060) |
| 必須 | A | EPD (NRULE_0208) | D-erythrose-4-phosphate dehydrogenase | HMPREF9086_3785 |
|---|
PDXB (NRULE_0209) | Erythronate-4-phosphate dehydrogenase | HMPREF9086_3236 |
SERC (NRULE_0210) | Phosphoserine aminotransferase | HMPREF9086_0917 |
PDXA (NRULE_0211) | 4-hydroxythreonine-4-phosphate dehydrogenase | HMPREF9086_1779 |
PDXJ (NRULE_0212) | Pyridoxine 5'-phosphate synthase | HMPREF9086_3413 |
