BLAST table : Chro_00300

DB	UniProtKB

	accession	Evalue	Score	Ident.	link	product	gene	organism	ec
1	Q70J68_STRGR (Q70J68)	0.0	837	100%	UniProt GenBank	Glycosyltransferase	cmmGIV	Streptomyces griseus subsp. griseus
2	Q194Q0_STRAA (Q194Q0)	1e-101	374	52%	UniProt GenBank	Glycosyltransferase	mtmGIV	Streptomyces argillaceus
3	D7BZR5_STRBB (D7BZR5)	7e-77	292	43%	UniProt GenBank	Glycosyl transferase, NDP-D-desosamine: 3-L-mycarosyl erythronolide B	SBI_06850	Streptomyces bingchenggensis (strain BCW-1)
4	C0JWA3_9ACTO (C0JWA3)	5e-67	259	43%	UniProt GenBank	PokGT1	pokGT1	Streptomyces diastatochromogenes
5	D8I4K4_AMYMU (D8I4K4)	2e-63	248	40%	UniProt GenBank	Putative glycosyl transferase	AMED_5418	Amycolatopsis mediterranei (strain U-32)
6	Q70J70_STRGR (Q70J70)	1e-61	242	44%	UniProt GenBank	Glycosyltransferase	cmmGIII	Streptomyces griseus subsp. griseus
7	B3TMN6_9ACTO (B3TMN6)	7e-61	239	41%	UniProt GenBank	Glycosyltransferase	KijA4	Actinomadura kijaniata
8	Q70J80_STRGR (Q70J80)	1e-59	235	41%	UniProt GenBank	Glycosyltransferase	cmmGI	Streptomyces griseus subsp. griseus
9	B3TMP5_9ACTO (B3TMP5)	5e-59	233	40%	UniProt GenBank	Glycosyltransferase	KijC1	Actinomadura kijaniata
10	B3TMP7_9ACTO (B3TMP7)	2e-58	231	39%	UniProt GenBank	Glycosyltransferase	KijC3	Actinomadura kijaniata
11	Q0R4P9_STRAT (Q0R4P9)	2e-58	231	39%	UniProt GenBank	ChlC7		Streptomyces antibioticus
12	D2AY79_STRRD (D2AY79)	2e-57	227	44%	UniProt GenBank	IroB	Sros_4185	Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
13	Q194P9_STRAA (Q194P9)	6e-55	219	39%	UniProt GenBank	Glycosyltransferase	mtmGIII	Streptomyces argillaceus
14	Q9ZGH7_9ACTO (Q9ZGH7)	3e-54	217	36%	UniProt GenBank	Glycosyl transferase	desVII	Streptomyces venezuelae
15	A4F7P3_SACEN (A4F7P3)	1e-53	215	35%	UniProt GenBank	Glycosyl transferase, NDP-D-desosamine : 3-L-mycarosyl erythronolide B	eryCIII SACE_0726	Saccharopolyspora erythraea (strain NRRL 23338)
16	O54224_SACER (O54224)	1e-53	215	35%	UniProt GenBank	Glycosyltransferase	eryCIII	Saccharopolyspora erythraea Streptomyces erythraeus
17	O33935_SACER (O33935)	1e-53	215	35%	UniProt GenBank	Desosaminyltransferase	eryCIII	Saccharopolyspora erythraea Streptomyces erythraeus
18	E5RLN7_9ACTO (E5RLN7)	4e-53	213	37%	UniProt GenBank	Putative glycosyltransferase	pnxGT2	Streptomyces sp. TA-0256
19	B5L6L8_MICCH (B5L6L8)	8e-53	212	35%	UniProt GenBank	Glycosyltransferase		Micromonospora chalcea
20	Q0R4N0_STRAT (Q0R4N0)	1e-52	212	37%	UniProt GenBank	ChlC6		Streptomyces antibioticus
21	D6AXN2_9ACTO (D6AXN2)	1e-52	212	37%	UniProt GenBank	RdmH	SSHG_05324	Streptomyces albus J1074
22	Q8KRX7_9ACTO (Q8KRX7)	2e-52	211	36%	UniProt GenBank	NbmD	nbmD	Streptomyces narbonensis
23	Q4JHQ3_9PSEU (Q4JHQ3)	6e-52	209	36%	UniProt GenBank	BusP	busP	Saccharopolyspora pogona
24	Q9ALN7_9PSEU (Q9ALN7)	5e-51	206	35%	UniProt GenBank	Probable NDP-forosamyltransferase	spnP	Saccharopolyspora spinosa
25	B5L6J8_MICCH (B5L6J8)	1e-50	205	37%	UniProt GenBank	Glycosyltransferase		Micromonospora chalcea
26	B5G890_9ACTO (B5G890)	2e-50	204	36%	UniProt GenBank	Glycosyltransferase family 28 domain-containing protein	SSBG_00498	Streptomyces sp. SPB74
27	B5L6L9_MICCH (B5L6L9)	3e-50	204	39%	UniProt GenBank	Glycosyltransferase		Micromonospora chalcea
28	O87831_STRAT (O87831)	4e-50	204	35%	UniProt GenBank	Glycosyltransferase	oleG2	Streptomyces antibioticus
29	B3TMR7_9ACTO (B3TMR7)	7e-50	202	37%	UniProt GenBank	Glycosyltransferase	KijD9	Actinomadura kijaniata
30	Q83WE1_MICGR (Q83WE1)	8e-50	202	36%	UniProt GenBank	Glycosyltransferase	mycB	Micromonospora griseorubida
31	D9T2A9_MICAI (D9T2A9)	1e-49	202	36%	UniProt GenBank	Putative uncharacterized protein	Micau_4012	Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
32	Q83X73_STRRO (Q83X73)	1e-49	202	34%	UniProt GenBank	Glycosyltransferase LkmI	lkmI	Streptomyces rochei Streptomyces parvullus
33	Q0PY15_STRMY (Q0PY15)	3e-49	201	37%	UniProt GenBank	Glycosyltransferase	midI	Streptomyces mycarofaciens
34	A4GV89_9ACTO (A4GV89)	3e-49	201	38%	UniProt GenBank	Glycosyltransferase	holN	Streptomyces sp. FU107
35	A8WDM7_9ACTO (A8WDM7)	3e-49	201	36%	UniProt GenBank	Glycosyltransferase		Streptomyces eurythermus
36	Q5Y9G8_9ACTO (Q5Y9G8)	3e-49	201	35%	UniProt GenBank	L-desosaminyltransferase	eryCIII	Aeromicrobium erythreum
37	D9VBX2_9ACTO (D9VBX2)	3e-49	201	37%	UniProt GenBank	Putative uncharacterized protein	SSMG_03360	Streptomyces sp. AA4
38	A7DWJ3_STRTE (A7DWJ3)	3e-48	197	41%	UniProt GenBank	Putative inactive gylcosyltransferase	llpG	Streptomyces tendae
39	Q2P9Y9_9ACTO (Q2P9Y9)	4e-48	197	37%	UniProt GenBank	Glycosyl transferase	stfG	Streptomyces steffisburgensis
40	Q194P5_STRAA (Q194P5)	4e-48	197	38%	UniProt GenBank	Glycosyltransferase	mtmGI	Streptomyces argillaceus
41	A0ACI7_STRAM (A0ACI7)	5e-48	196	34%	UniProt GenBank	Putative glycosyltransferase	SAMR0481	Streptomyces ambofaciens ATCC 23877
42	D9T2A6_MICAI (D9T2A6)	9e-48	196	35%	UniProt GenBank	Putative uncharacterized protein	Micau_4009	Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
43	E8RWS3_MICSL (E8RWS3)	1e-47	195	36%	UniProt GenBank	Putative uncharacterized protein	ML5_4412	Micromonospora sp. (strain L5)
44	O87830_STRAT (O87830)	1e-47	195	34%	UniProt GenBank	Glycosyltransferase	oleG1	Streptomyces antibioticus
45	D8I4K0_AMYMU (D8I4K0)	2e-47	195	35%	UniProt GenBank	Putative glycosyl transferase	AMED_5414	Amycolatopsis mediterranei (strain U-32)
46	Q76KZ6_STRHA (Q76KZ6)	2e-47	195	35%	UniProt GenBank	Glycosyltransferase	vinC	Streptomyces halstedii
47	E8RWS0_MICSL (E8RWS0)	2e-47	194	36%	UniProt GenBank	Putative uncharacterized protein	ML5_4409	Micromonospora sp. (strain L5)
48	Q9L555_9ACTO (Q9L555)	2e-47	194	36%	UniProt GenBank	AknK	aknK	Streptomyces galilaeus
49	Q9F839_9ACTO (Q9F839)	3e-47	194	33%	UniProt GenBank	TDP-megosamine glycosyltransferase	megDI	Micromonospora megalomicea subsp. nigra
50	Q9L4U6_9ACTO (Q9L4U6)	4e-47	193	37%	UniProt GenBank	Putative glycosyl transferase	aknS	Streptomyces galilaeus
51	E8RWS4_MICSL (E8RWS4)	4e-47	193	33%	UniProt GenBank	Putative uncharacterized protein	ML5_4413	Micromonospora sp. (strain L5)
52	D9T2A5_MICAI (D9T2A5)	4e-47	193	33%	UniProt GenBank	Putative uncharacterized protein	Micau_4008	Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
53	B3TMP8_9ACTO (B3TMP8)	5e-47	193	39%	UniProt GenBank	Glycosyltransferase	KijC4	Actinomadura kijaniata
54	A8Y8F5_STRAM (A8Y8F5)	2e-46	191	36%	UniProt GenBank	Probable glycosyltransferase	srm3*c	Streptomyces ambofaciens
55	D5UX47_TSUPD (D5UX47)	5e-46	190	35%	UniProt GenBank	Putative uncharacterized protein	Tpau_3487	Tsukamurella paurometabola (strain ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040) Corynebacterium paurometabolum
56	D7BZT2_STRBB (D7BZT2)	6e-46	189	37%	UniProt GenBank	IroB	SBI_06867	Streptomyces bingchenggensis (strain BCW-1)
57	Q54824_STRPE (Q54824)	1e-45	189	35%	UniProt GenBank	Glycosyl transferase	dnrS	Streptomyces peucetius
58	D8I4I4_AMYMU (D8I4I4)	1e-45	189	35%	UniProt GenBank	Putative glycosyl transferase	AMED_5398	Amycolatopsis mediterranei (strain U-32)
59	E0KQM6_STRVO (E0KQM6)	1e-45	188	33%	UniProt GenBank	Putative uncharacterized protein	StrviDRAFT_4953	Streptomyces violaceusniger Tu 4113
60	E8S036_MICSL (E8S036)	1e-45	188	41%	UniProt GenBank	Putative uncharacterized protein	ML5_4680	Micromonospora sp. (strain L5)
61	Q9F826_9ACTO (Q9F826)	1e-45	188	36%	UniProt GenBank	TDP-desosamine glycosyltransferase	megCIII	Micromonospora megalomicea subsp. nigra
62	D7BZS3_STRBB (D7BZS3)	1e-45	188	35%	UniProt GenBank	Glycosyl transferase, NDP-D-desosamine: 3-L-mycarosyl erythronolide B	SBI_06858	Streptomyces bingchenggensis (strain BCW-1)
63	B5G8A2_9ACTO (B5G8A2)	2e-45	187	38%	UniProt GenBank	Glycosyltransferase family 28 domain-containing protein	SSBG_00510	Streptomyces sp. SPB74
64	A4FFB3_SACEN (A4FFB3)	3e-45	187	38%	UniProt GenBank	Putative uncharacterized protein	SACE_3464	Saccharopolyspora erythraea (strain NRRL 23338)
65	Q8VWB7_9ACTO (Q8VWB7)	4e-45	187	35%	UniProt GenBank	AclK	aclK	Streptomyces galilaeus
66	D9SZA9_MICAI (D9SZA9)	6e-45	186	40%	UniProt GenBank	Putative uncharacterized protein	Micau_3719	Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
67	E5L4T5_9ACTO (E5L4T5)	6e-45	186	33%	UniProt GenBank	Glycosyltransferase		Streptomyces sp. SCSIO 01934
68	P95834_STRPE (P95834)	2e-44	184	35%	UniProt GenBank	Putative baumycin biosynthesis protein	dnrH	Streptomyces peucetius
69	A1C188_9ACTO (A1C188)	2e-44	184	35%	UniProt GenBank	L-rhamnosyltransferase		Streptomyces echinatus
70	P95747_STRFR (P95747)	3e-44	184	34%	UniProt GenBank	Glycosyltransferase	tylMII(orf2*)	Streptomyces fradiae Streptomyces roseoflavus
71	Q935Z8_9ACTO (Q935Z8)	3e-44	184	35%	UniProt GenBank	RdmH	rdmH	Streptomyces purpurascens
72	A4GV85_9ACTO (A4GV85)	4e-44	183	36%	UniProt GenBank	Glycosyltransferase	holC	Streptomyces rufochromogenes
73	Q9RIP9_STRNO (Q9RIP9)	9e-44	182	36%	UniProt GenBank	SnogZ	snogZ	Streptomyces nogalater
74	Q9RN63_STRNO (Q9RN63)	9e-44	182	36%	UniProt GenBank	Putative glycosyl transferase	snogE	Streptomyces nogalater
75	Q6T1C7_STRGL (Q6T1C7)	1e-43	182	34%	UniProt GenBank	Glycosyltransferase LndGT4		Streptomyces globisporus
76	A8Y8I1_STRAM (A8Y8I1)	1e-43	182	33%	UniProt GenBank	Probable glycosyltransferase	srm17	Streptomyces ambofaciens
77	B0LJ53_9ACTO (B0LJ53)	2e-43	181	33%	UniProt GenBank	Lcz36	lcz36	Streptomyces sanglieri
78	C4NYM1_9ACTO (C4NYM1)	2e-43	181	35%	UniProt GenBank	SaqGT6	saqGT6	Micromonospora sp. Tu 6368
79	C4NYK7_9ACTO (C4NYK7)	2e-43	181	34%	UniProt GenBank	SaqGT1	saqGT1	Micromonospora sp. Tu 6368
80	Q0H2X6_9ACTO (Q0H2X6)	2e-43	181	35%	UniProt GenBank	Putative O-glycosyltransferase	atG1	Actinomadura melliaura
81	D8I4J6_AMYMU (D8I4J6)	3e-43	181	35%	UniProt GenBank	Putative glycosyl transferase	AMED_5410	Amycolatopsis mediterranei (strain U-32)
82	E8RWU6_MICSL (E8RWU6)	4e-43	180	38%	UniProt GenBank	Putative uncharacterized protein	ML5_4435	Micromonospora sp. (strain L5)
83	D9T283_MICAI (D9T283)	4e-43	180	38%	UniProt GenBank	Putative uncharacterized protein	Micau_3986	Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
84	Q2I780_9ACTO (Q2I780)	4e-43	180	37%	UniProt GenBank	PlaA6	plaA6 STTU_1431	Streptomyces sp. Tu6071
85	Q5SFB5_STRBI (Q5SFB5)	5e-43	180	33%	UniProt GenBank	Putative chalcose glycosyltransferase	chmCIII	Streptomyces bikiniensis
86	D7B014_NOCDD (D7B014)	8e-43	179	35%	UniProt GenBank	Putative uncharacterized protein	Ndas_4716	Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488) Actinomadura dassonvillei
87	Q331Q0_9ACTO (Q331Q0)	8e-43	179	33%	UniProt GenBank	Chalcosyltransferase	gerTII	Streptomyces sp. KCTC 0041BP
88	B4VEK6_9ACTO (B4VEK6)	1e-42	178	33%	UniProt GenBank	Chalcosyltransferase	SSAG_06216	Streptomyces sp. Mg1
89	D6AT98_STRFL (D6AT98)	1e-42	178	35%	UniProt GenBank	AknK	SSGG_05542	Streptomyces roseosporus NRRL 15998
90	B0LJ19_9ACTO (B0LJ19)	2e-42	178	33%	UniProt GenBank	Lct36	lct36	Streptomyces rishiriensis
91	Q2HR28_9ACTO (Q2HR28)	2e-42	178	35%	UniProt GenBank	Putative O-glycosyltransferase	schS9	Streptomyces sp. SCC 2136
92	D8I4J8_AMYMU (D8I4J8)	3e-42	177	35%	UniProt GenBank	Putative glycosyl transferase	AMED_5412	Amycolatopsis mediterranei (strain U-32)
93	Q9ZGB8_STRCY (Q9ZGB8)	4e-42	177	34%	UniProt GenBank	Glycosyl transferase homolog	lanGT1	Streptomyces cyanogenus
94	Q9ZGB1_STRCY (Q9ZGB1)	4e-42	177	34%	UniProt GenBank	Glycosyl transferase homolog	lanGT4	Streptomyces cyanogenus
95	Q53881_STRS5 (Q53881)	4e-42	177	34%	UniProt GenBank	Glycosyltransferase	dauH	Streptomyces sp. (strain C5)
96	D9UBQ5_STRPR (D9UBQ5)	1e-41	175	35%	UniProt GenBank	Putative glycosyltransferase	cpp29	Streptomyces pristinaespiralis	2.4.1.- niceE keggE
97	D6X7X2_STRPR (D6X7X2)	1e-41	175	35%	UniProt GenBank	Glycosyltransferase LndGT4	SSDG_07505	Streptomyces pristinaespiralis ATCC 25486
98	D8I4J7_AMYMU (D8I4J7)	2e-41	174	34%	UniProt GenBank	Putative glycosyl transferase	AMED_5411	Amycolatopsis mediterranei (strain U-32)
99	D7BZS5_STRBB (D7BZS5)	3e-41	174	34%	UniProt GenBank	IroB	SBI_06860	Streptomyces bingchenggensis (strain BCW-1)
100	D7AZB3_NOCDD (D7AZB3)	4e-41	173	36%	UniProt GenBank	Putative uncharacterized protein	Ndas_4707	Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488) Actinomadura dassonvillei

accession

alignment

Evalue

Score

Ident.

link

information

pubmed

Q194Q0_STRAA
(Q194Q0)

1e-101

374

52%

Product: Glycosyltransferase
Gene: mtmGIV
Organism: Streptomyces argillaceus

[pubmed all]
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]

D7BZR5_STRBB
(D7BZR5)

7e-77

292

43%

Product: Glycosyl transferase, NDP-D-desosamine: 3-L-mycarosyl erythronolide B
Gene: SBI_06850
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

C0JWA3_9ACTO
(C0JWA3)

5e-67

259

43%

Product: PokGT1
Gene: pokGT1
Organism: Streptomyces diastatochromogenes

1uniprot[Pubmed] 19266534
Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009]

D8I4K4_AMYMU
(D8I4K4)

2e-63

248

40%

Product: Putative glycosyl transferase
Gene: AMED_5418
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

B3TMN6_9ACTO
(B3TMN6)

7e-61

239

41%

Product: Glycosyltransferase
Gene: KijA4
Organism: Actinomadura kijaniata

1uniprot[Pubmed] 17985890
Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007]

B3TMP5_9ACTO
(B3TMP5)

5e-59

233

40%

Product: Glycosyltransferase
Gene: KijC1
Organism: Actinomadura kijaniata

1uniprot[Pubmed] 17985890
Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007]

B3TMP7_9ACTO
(B3TMP7)

2e-58

231

39%

Product: Glycosyltransferase
Gene: KijC3
Organism: Actinomadura kijaniata

1uniprot[Pubmed] 17985890
Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007]

Q0R4P9_STRAT
(Q0R4P9)

2e-58

231

39%

Product: ChlC7
Gene
Organism: Streptomyces antibioticus

1uniprot[Pubmed] 16793515
Genetic characterization of the chlorothricin gene cluster as a model for spirotetronate antibiotic biosynthesis.(Chem. Biol.) [2006]

D2AY79_STRRD
(D2AY79)

2e-57

227

44%

Product: IroB
Gene: Sros_4185
Organism: Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)

1uniprot
Complete genome sequence of Streptosporangium roseum type strain (NI 9100T).(Stand. Genomic Sci.) [2010]

Q194P9_STRAA
(Q194P9)

6e-55

219

39%

Product: Glycosyltransferase
Gene: mtmGIII
Organism: Streptomyces argillaceus

[pubmed all]
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]

Q9ZGH7_9ACTO
(Q9ZGH7)

3e-54

217

36%

Product: Glycosyl transferase
Gene: desVII
Organism: Streptomyces venezuelae

1uniprot[Pubmed] 9770448 [Medline] 98445333
A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity.(Proc. Natl. Acad. Sci. U.S.A.) [1998]

A4F7P3_SACEN
(A4F7P3)

1e-53

215

35%

Product: Glycosyl transferase, NDP-D-desosamine : 3-L-mycarosyl erythronolide B
Gene: eryCIII
SACE_0726
Organism: Saccharopolyspora erythraea (strain NRRL 23338)

1uniprot[Pubmed] 17369815
Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007]

O33935_SACER
(O33935)

1e-53

215

35%

Product: Desosaminyltransferase
Gene: eryCIII
Organism: Saccharopolyspora erythraea
Streptomyces erythraeus

1uniprot[Pubmed] 9353926 [Medline] 98015410
Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production.(Microbiology)

B5L6L8_MICCH
(B5L6L8)

8e-53

212

35%

Product: Glycosyltransferase
Gene
Organism: Micromonospora chalcea

1uniprot[Pubmed] 18586939
Cloning and characterization of the tetrocarcin A gene cluster from Micromonospora chalcea NRRL 11289 reveals a highly conserved strategy for tetronate biosynthesis in spirotetronate antibiotics.(J. Bacteriol.) [2008]

Q0R4N0_STRAT
(Q0R4N0)

1e-52

212

37%

Product: ChlC6
Gene
Organism: Streptomyces antibioticus

1uniprot[Pubmed] 16793515
Genetic characterization of the chlorothricin gene cluster as a model for spirotetronate antibiotic biosynthesis.(Chem. Biol.) [2006]

Q4JHQ3_9PSEU
(Q4JHQ3)

6e-52

209

36%

Product: BusP
Gene: busP
Organism: Saccharopolyspora pogona

1uniprot[Pubmed] 16179985
Butenyl-spinosyns, a natural example of genetic engineering of antibiotic biosynthetic genes.(J. Ind. Microbiol. Biotechnol.) [2006]

Q9ALN7_9PSEU
(Q9ALN7)

5e-51

206

35%

Product: Probable NDP-forosamyltransferase
Gene: spnP
Organism: Saccharopolyspora spinosa

1uniprot[Pubmed] 11358695 [Medline] 21257765
Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa.(Chem. Biol.) [2001]

B5L6J8_MICCH
(B5L6J8)

1e-50

205

37%

Product: Glycosyltransferase
Gene
Organism: Micromonospora chalcea

B5L6L9_MICCH
(B5L6L9)

3e-50

204

39%

Product: Glycosyltransferase
Gene
Organism: Micromonospora chalcea

O87831_STRAT
(O87831)

4e-50

204

35%

Product: Glycosyltransferase
Gene: oleG2
Organism: Streptomyces antibioticus

1uniprot[Pubmed] 9749673 [Medline] 98420102
Analysis of a Streptomyces antibioticus chromosomal region involved in oleandomycin biosynthesis, which encodes two glycosyltransferases responsible for glycosylation of the macrolactone ring.(Mol. Gen. Genet.) [1998]

B3TMR7_9ACTO
(B3TMR7)

7e-50

202

37%

Product: Glycosyltransferase
Gene: KijD9
Organism: Actinomadura kijaniata

1uniprot[Pubmed] 17985890
Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007]

Q83WE1_MICGR
(Q83WE1)

8e-50

202

36%

Product: Glycosyltransferase
Gene: mycB
Organism: Micromonospora griseorubida

1uniprot[Pubmed] 12583909 [Medline] 22472038
Organization of the biosynthetic gene cluster for the polyketide macrolide mycinamicin in Micromonospora griseorubida.(FEMS Microbiol. Lett.) [2003]

Q83X73_STRRO
(Q83X73)

1e-49

202

34%

Product: Glycosyltransferase LkmI
Gene: lkmI
Organism: Streptomyces rochei
Streptomyces parvullus

[pubmed all]
1uniprot[Pubmed] 12791134 [Medline] 22676866 The large linear plasmid pSLA2-L of Streptomyces rochei has an unusually condensed gene organization for secondary metabolism.(Mol. Microbiol.) [2003]
2uniprot[Pubmed] 10954087 [Medline] 20408175 Cloning and analysis of the replication origin and the telomeres of the large linear plasmid pSLA2-L in Streptomyces rochei.(Mol. Gen. Genet.) [2000]
3uniprot[Pubmed] 10767533 [Medline] 20231737 Identification of two polyketide synthase gene clusters on the linear plasmid pSLA2-L in Streptomyces rochei.(Gene) [2000]
4uniprot[Pubmed] 9836424 [Medline] 99053144 Physical mapping of the linear plasmid pSLA2-L and localization of the eryAI and actI homologs.(Biosci. Biotechnol. Biochem.) [1998]

Q0PY15_STRMY
(Q0PY15)

3e-49

201

37%

Product: Glycosyltransferase
Gene: midI
Organism: Streptomyces mycarofaciens

1uniprot[Pubmed] 17342257
Cloning and characterization of genes encoded in dTDP-D-mycaminose biosynthetic pathway from a midecamycin-producing strain, Streptomyces mycarofaciens.(Acta Biochim. Biophys. Sin.) [2007]

A4GV89_9ACTO
(A4GV89)

3e-49

201

38%

Product: Glycosyltransferase
Gene: holN
Organism: Streptomyces sp. FU107

1uniprot[Pubmed] 17497146
A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]

Q5Y9G8_9ACTO
(Q5Y9G8)

3e-49

201

35%

Product: L-desosaminyltransferase
Gene: eryCIII
Organism: Aeromicrobium erythreum

1uniprot[Pubmed] 15257441
The erythromycin biosynthetic gene cluster of Aeromicrobium erythreum.(J. Ind. Microbiol. Biotechnol.) [2004]

A7DWJ3_STRTE
(A7DWJ3)

3e-48

197

41%

Product: Putative inactive gylcosyltransferase
Gene: llpG
Organism: Streptomyces tendae

1uniprot
Isolation of the lysolipin gene cluster of Streptomyces tendae Tu 4042.(Gene) [2010]

Q2P9Y9_9ACTO
(Q2P9Y9)

4e-48

197

37%

Product: Glycosyl transferase
Gene: stfG
Organism: Streptomyces steffisburgensis

1uniprot[Pubmed] 16751529
Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin.(Appl. Environ. Microbiol.) [2006]

Q194P5_STRAA
(Q194P5)

4e-48

197

38%

Product: Glycosyltransferase
Gene: mtmGI
Organism: Streptomyces argillaceus

[pubmed all]
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]

A0ACI7_STRAM
(A0ACI7)

5e-48

196

34%

Product: Putative glycosyltransferase
Gene: SAMR0481
Organism: Streptomyces ambofaciens ATCC 23877

1uniprot[Pubmed] 16956972
Evolution of the terminal regions of the Streptomyces linear chromosome.(Mol. Biol. Evol.) [2006]

2uniprot
Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877.(Microbiology (Mosc.)) [2006]

O87830_STRAT
(O87830)

1e-47

195

34%

Product: Glycosyltransferase
Gene: oleG1
Organism: Streptomyces antibioticus

D8I4K0_AMYMU
(D8I4K0)

2e-47

195

35%

Product: Putative glycosyl transferase
Gene: AMED_5414
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

Q76KZ6_STRHA
(Q76KZ6)

2e-47

195

35%

Product: Glycosyltransferase
Gene: vinC
Organism: Streptomyces halstedii

1uniprot[Pubmed] 15112997
Cloning, sequencing, and functional analysis of the biosynthetic gene cluster of macrolactam antibiotic vicenistatin in Streptomyces halstedii.(Chem. Biol.) [2004]

Q9L555_9ACTO
(Q9L555)

2e-47

194

36%

Product: AknK
Gene: aknK
Organism: Streptomyces galilaeus

1uniprot[Pubmed] 12137949 [Medline] 22133312
Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster.(Gene) [2002]

Q9F839_9ACTO
(Q9F839)

3e-47

194

33%

Product: TDP-megosamine glycosyltransferase
Gene: megDI
Organism: Micromonospora megalomicea subsp. nigra

1uniprot[Pubmed] 10972798 [Medline] 20430101
Biosynthesis of the anti-parasitic agent megalomicin: transformation of erythromycin to megalomicin in Saccharopolyspora erythraea.(Mol. Microbiol.) [2000]

Q9L4U6_9ACTO
(Q9L4U6)

4e-47

193

37%

Product: Putative glycosyl transferase
Gene: aknS
Organism: Streptomyces galilaeus

1uniprot[Pubmed] 11016846 [Medline] 20469061
A gene cluster from Streptomyces galilaeus involved in glycosylation of aclarubicin.(Mol. Gen. Genet.) [2000]

B3TMP8_9ACTO
(B3TMP8)

5e-47

193

39%

Product: Glycosyltransferase
Gene: KijC4
Organism: Actinomadura kijaniata

1uniprot[Pubmed] 17985890
Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007]

A8Y8F5_STRAM
(A8Y8F5)

2e-46

191

36%

Product: Probable glycosyltransferase
Gene: srm3*c
Organism: Streptomyces ambofaciens

1uniprot
Organization of the biosynthetic gene cluster for the macrolide antibiotic spiramycin in Streptomyces ambofaciens.(Microbiology (Mosc.)) [2007]

D7BZT2_STRBB
(D7BZT2)

6e-46

189

37%

Product: IroB
Gene: SBI_06867
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

Q54824_STRPE
(Q54824)

1e-45

189

35%

Product: Glycosyl transferase
Gene: dnrS
Organism: Streptomyces peucetius

1uniprot[Pubmed] 7592454 [Medline] 96062261
Cloning and characterization of the Streptomyces peucetius dnrQS genes encoding a daunosamine biosynthesis enzyme and a glycosyl transferase involved in daunorubicin biosynthesis.(J. Bacteriol.) [1995]

D8I4I4_AMYMU
(D8I4I4)

1e-45

189

35%

Product: Putative glycosyl transferase
Gene: AMED_5398
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

Q9F826_9ACTO
(Q9F826)

1e-45

188

36%

Product: TDP-desosamine glycosyltransferase
Gene: megCIII
Organism: Micromonospora megalomicea subsp. nigra

D7BZS3_STRBB
(D7BZS3)

1e-45

188

35%

Product: Glycosyl transferase, NDP-D-desosamine: 3-L-mycarosyl erythronolide B
Gene: SBI_06858
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

A4FFB3_SACEN
(A4FFB3)

3e-45

187

38%

Product: Putative uncharacterized protein
Gene: SACE_3464
Organism: Saccharopolyspora erythraea (strain NRRL 23338)

1uniprot[Pubmed] 17369815
Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007]

Q8VWB7_9ACTO
(Q8VWB7)

4e-45

187

35%

Product: AclK
Gene: aclK
Organism: Streptomyces galilaeus

1uniprot[Pubmed] 12399480 [Medline] 22286521
Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus.(J. Bacteriol.) [2002]

P95834_STRPE
(P95834)

2e-44

184

35%

Product: Putative baumycin biosynthesis protein
Gene: dnrH
Organism: Streptomyces peucetius

[pubmed all]
1uniprot[Pubmed] 8955419 [Medline] 97113559 Enhanced antibiotic production by manipulation of the Streptomyces peucetius dnrH and dnmT genes involved in doxorubicin (adriamycin) biosynthesis.(J. Bacteriol.) [1996]
2uniprot[Pubmed] 9864344 [Medline] 99084971 Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene.(J. Bacteriol.) [1999]

P95747_STRFR
(P95747)

3e-44

184

34%

Product: Glycosyltransferase
Gene: tylMII(orf2*)
Organism: Streptomyces fradiae
Streptomyces roseoflavus

1uniprot[Pubmed] 9031628 [Medline] 97183662
Analysis of four tylosin biosynthetic genes from the tylLM region of Streptomyces fradiae.(Gene) [1997]

A4GV85_9ACTO
(A4GV85)

4e-44

183

36%

Product: Glycosyltransferase
Gene: holC
Organism: Streptomyces rufochromogenes

1uniprot[Pubmed] 17497146
A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]

Q9RIP9_STRNO
(Q9RIP9)

9e-44

182

36%

Product: SnogZ
Gene: snogZ
Organism: Streptomyces nogalater

[pubmed all]
1uniprot[Pubmed] 8668120 [Medline] 96242142 A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.(Mol. Gen. Genet.) [1996]
2uniprot[Pubmed] 9349712 [Medline] 98007868 Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.(Mol. Gen. Genet.) [1997]
3uniprot[Pubmed] 8760909 [Medline] 96349102 Production of hybrid anthracycline antibiotics by heterologous expression of Streptomyces nogalater nogalamycin biosynthesis genes.(Microbiology) [1996]

Q9RN63_STRNO
(Q9RN63)

9e-44

182

36%

Product: Putative glycosyl transferase
Gene: snogE
Organism: Streptomyces nogalater

[pubmed all]
1uniprot[Pubmed] 9349712 [Medline] 98007868 Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.(Mol. Gen. Genet.) [1997]
2uniprot[Pubmed] 10639368 [Medline] 20106987 Identification of a cyclase gene dictating the C-9 stereochemistry of anthracyclines from Streptomyces nogalater.(Antimicrob. Agents Chemother.) [2000]

Q6T1C7_STRGL
(Q6T1C7)

1e-43

182

34%

Product: Glycosyltransferase LndGT4
Gene
Organism: Streptomyces globisporus

1uniprot[Pubmed] 15123249
Generation of new landomycins by combinatorial biosynthetic manipulation of the LndGT4 gene of the landomycin E cluster in S. globisporus.(Chem. Biol.) [2004]

A8Y8I1_STRAM
(A8Y8I1)

1e-43

182

33%

Product: Probable glycosyltransferase
Gene: srm17
Organism: Streptomyces ambofaciens

1uniprot
Organization of the biosynthetic gene cluster for the macrolide antibiotic spiramycin in Streptomyces ambofaciens.(Microbiology (Mosc.)) [2007]

B0LJ53_9ACTO
(B0LJ53)

2e-43

181

33%

Product: Lcz36
Gene: lcz36
Organism: Streptomyces sanglieri

1uniprot[Pubmed] 18070976
Biosynthetic investigations of lactonamycin and lactonamycin z: cloning of the biosynthetic gene clusters and discovery of an unusual starter unit.(Antimicrob. Agents Chemother.) [2008]

C4NYM1_9ACTO
(C4NYM1)

2e-43

181

35%

Product: SaqGT6
Gene: saqGT6
Organism: Micromonospora sp. Tu 6368

[pubmed all]
1uniprot[Pubmed] 17497146 A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]
2uniprot[Pubmed] 19384899 Cloning and sequencing of the biosynthetic gene cluster for saquayamycin z and galtamycin B and the elucidation of the assembly of their saccharide chains.(Chembiochem) [2009]

C4NYK7_9ACTO
(C4NYK7)

2e-43

181

34%

Product: SaqGT1
Gene: saqGT1
Organism: Micromonospora sp. Tu 6368

[pubmed all]
1uniprot[Pubmed] 17497146 A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]
2uniprot[Pubmed] 19384899 Cloning and sequencing of the biosynthetic gene cluster for saquayamycin z and galtamycin B and the elucidation of the assembly of their saccharide chains.(Chembiochem) [2009]

Q0H2X6_9ACTO
(Q0H2X6)

2e-43

181

35%

Product: Putative O-glycosyltransferase
Gene: atG1
Organism: Actinomadura melliaura

1uniprot[Pubmed] 16873021
Deciphering indolocarbazole and enediyne aminodideoxypentose biosynthesis through comparative genomics: insights from the AT2433 biosynthetic locus.(Chem. Biol.) [2006]

D8I4J6_AMYMU
(D8I4J6)

3e-43

181

35%

Product: Putative glycosyl transferase
Gene: AMED_5410
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

Q2I780_9ACTO
(Q2I780)

4e-43

180

37%

Product: PlaA6
Gene: plaA6
STTU_1431
Organism: Streptomyces sp. Tu6071

1uniprot[Pubmed] 16632249
Biosynthesis of the terpene phenalinolactone in Streptomyces sp. Tu6071: analysis of the gene cluster and generation of derivatives.(Chem. Biol.) [2006]

Q5SFB5_STRBI
(Q5SFB5)

5e-43

180

33%

Product: Putative chalcose glycosyltransferase
Gene: chmCIII
Organism: Streptomyces bikiniensis

1uniprot[Pubmed] 15561847
Chalcomycin biosynthesis gene cluster from Streptomyces bikiniensis: novel features of an unusual ketolide produced through expression of the chm polyketide synthase in Streptomyces fradiae.(Antimicrob. Agents Chemother.) [2004]

D7B014_NOCDD
(D7B014)

8e-43

179

35%

Product: Putative uncharacterized protein
Gene: Ndas_4716
Organism: Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei

1uniprot
Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010]

Q331Q0_9ACTO
(Q331Q0)

8e-43

179

33%

Product: Chalcosyltransferase
Gene: gerTII
Organism: Streptomyces sp. KCTC 0041BP

1uniprot[Pubmed] 17053005
Biosynthesis of dTDP-6-deoxy-beta-D-allose, biochemical characterization of dTDP-4-keto-6-deoxyglucose reductase (GerKI) from Streptomyces sp. KCTC 0041BP.(Glycobiology) [2007]

2uniprot
Cloning and characterization of a gene cluster for the production of the polyketide macrolide antibiotic dihydrochalcomycin in Streptomyces sp. KCTC 0041BP.(J. Microbiol. Biotechnol.) [2006]

B0LJ19_9ACTO
(B0LJ19)

2e-42

178

33%

Product: Lct36
Gene: lct36
Organism: Streptomyces rishiriensis

Q2HR28_9ACTO
(Q2HR28)

2e-42

178

35%

Product: Putative O-glycosyltransferase
Gene: schS9
Organism: Streptomyces sp. SCC 2136

1uniprot
Angucyclines Sch 47554 and Sch 47555 from Streptomyces sp. SCC-2136: Cloning, Sequencing, and Characterization.(Mol. Cells) [2006]

2uniprot
Molecular cloning and characterization of biosynthetic genes cluster of Sch 47554 from Streptomyces sp. SCC 2136. [2004]

D8I4J8_AMYMU
(D8I4J8)

3e-42

177

35%

Product: Putative glycosyl transferase
Gene: AMED_5412
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

Q9ZGB8_STRCY
(Q9ZGB8)

4e-42

177

34%

Product: Glycosyl transferase homolog
Gene: lanGT1
Organism: Streptomyces cyanogenus

1uniprot[Pubmed] 9933932 [Medline] 99132695
Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin biosynthesis.(FEMS Microbiol. Lett.) [1999]

Q9ZGB1_STRCY
(Q9ZGB1)

4e-42

177

34%

Product: Glycosyl transferase homolog
Gene: lanGT4
Organism: Streptomyces cyanogenus

Q53881_STRS5
(Q53881)

4e-42

177

34%

Product: Glycosyltransferase
Gene: dauH
Organism: Streptomyces sp. (strain C5)

1uniprot[Pubmed] 8655529 [Medline] 96236066
Cloning, sequencing, and analysis of aklaviketone reductase from Streptomyces sp. strain C5.(J. Bacteriol.) [1996]

D9UBQ5_STRPR
(D9UBQ5)

1e-41

175

35%

Product: Putative glycosyltransferase
Gene: cpp29
Organism: Streptomyces pristinaespiralis

1uniprot[Pubmed] 21342465
Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011]

D8I4J7_AMYMU
(D8I4J7)

2e-41

174

34%

Product: Putative glycosyl transferase
Gene: AMED_5411
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

D7BZS5_STRBB
(D7BZS5)

3e-41

174

34%

Product: IroB
Gene: SBI_06860
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

100

D7AZB3_NOCDD
(D7AZB3)

4e-41

173

36%

Product: Putative uncharacterized protein
Gene: Ndas_4707
Organism: Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei

1uniprot
Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010]