BLAST table : Sch475_00300

DB	UniProtKB

	accession	Evalue	Score	Ident.	link	product	gene	organism	ec
1	Q2HR28_9ACTO (Q2HR28)	0.0	761	100%	UniProt GenBank	Putative O-glycosyltransferase	schS9	Streptomyces sp. SCC 2136
2	Q9RP99_STRFR (Q9RP99)	1e-116	422	59%	UniProt GenBank	Glycosyl transferase	urdGT1c	Streptomyces fradiae Streptomyces roseoflavus
3	Q9RPA1_STRFR (Q9RPA1)	1e-114	418	59%	UniProt GenBank	Glycosyl transferase	urdGT1b	Streptomyces fradiae Streptomyces roseoflavus
4	D7BZS3_STRBB (D7BZS3)	1e-111	407	56%	UniProt GenBank	Glycosyl transferase, NDP-D-desosamine: 3-L-mycarosyl erythronolide B	SBI_06858	Streptomyces bingchenggensis (strain BCW-1)
5	C4NYL1_9ACTO (C4NYL1)	1e-111	407	58%	UniProt GenBank	SaqGT4	saqGT4	Micromonospora sp. Tu 6368
6	Q9ZGB8_STRCY (Q9ZGB8)	1e-105	387	55%	UniProt GenBank	Glycosyl transferase homolog	lanGT1	Streptomyces cyanogenus
7	C4NYL0_9ACTO (C4NYL0)	1e-105	385	54%	UniProt GenBank	SaqGT3	saqGT3	Micromonospora sp. Tu 6368
8	A4GV88_9ACTO (A4GV88)	3e-99	367	50%	UniProt GenBank	Glycosyltransferase	holL	Streptomyces sp. Tu1156
9	Q6QR18_STRGL (Q6QR18)	1e-96	357	55%	UniProt GenBank	Glycosyl transferase		Streptomyces globisporus
10	D7BZS5_STRBB (D7BZS5)	3e-89	333	49%	UniProt GenBank	IroB	SBI_06860	Streptomyces bingchenggensis (strain BCW-1)
11	A4GV86_9ACTO (A4GV86)	7e-85	318	46%	UniProt GenBank	Glycosyltransferase	holA	Streptomyces sp. FU107
12	Q9ZGB4_STRCY (Q9ZGB4)	2e-83	314	49%	UniProt GenBank	Glycosyl transferase homolog	lanGT3	Streptomyces cyanogenus
13	E5RLN7_9ACTO (E5RLN7)	1e-73	281	43%	UniProt GenBank	Putative glycosyltransferase	pnxGT2	Streptomyces sp. TA-0256
14	Q4JHR2_9PSEU (Q4JHR2)	2e-58	231	37%	UniProt GenBank	BusG	busG	Saccharopolyspora pogona
15	Q9ALM8_9PSEU (Q9ALM8)	3e-55	220	35%	UniProt GenBank	Probable NDP-rhamnosyltransferase	spnG	Saccharopolyspora spinosa
16	D7BZR2_STRBB (D7BZR2)	1e-54	218	42%	UniProt GenBank	Glycosyl transferase, NDP-D-desosamine: 3-L-mycarosyl erythronolide B	SBI_06847	Streptomyces bingchenggensis (strain BCW-1)
17	C0JWA0_9ACTO (C0JWA0)	5e-52	209	39%	UniProt GenBank	PokGT2	pokGT2	Streptomyces diastatochromogenes
18	D8I4K4_AMYMU (D8I4K4)	3e-49	200	35%	UniProt GenBank	Putative glycosyl transferase	AMED_5418	Amycolatopsis mediterranei (strain U-32)
19	D8I4K0_AMYMU (D8I4K0)	4e-48	196	35%	UniProt GenBank	Putative glycosyl transferase	AMED_5414	Amycolatopsis mediterranei (strain U-32)
20	Q194P9_STRAA (Q194P9)	6e-48	196	36%	UniProt GenBank	Glycosyltransferase	mtmGIII	Streptomyces argillaceus
21	Q4R0L9_STRCX (Q4R0L9)	6e-46	189	36%	UniProt GenBank	ChaGT1 protein	chaGT1	Streptomyces chartreusis
22	D8I4J9_AMYMU (D8I4J9)	2e-45	187	36%	UniProt GenBank	Putative glycosyl transferase	AMED_5413	Amycolatopsis mediterranei (strain U-32)
23	Q70J70_STRGR (Q70J70)	3e-45	187	36%	UniProt GenBank	Glycosyltransferase	cmmGIII	Streptomyces griseus subsp. griseus
24	Q8GHC2_9ACTO (Q8GHC2)	3e-43	180	37%	UniProt GenBank	Glycosyltransferase	cloM	Streptomyces roseochromogenes subsp. oscitans
25	Q70J80_STRGR (Q70J80)	7e-43	179	34%	UniProt GenBank	Glycosyltransferase	cmmGI	Streptomyces griseus subsp. griseus
26	Q70J68_STRGR (Q70J68)	2e-42	178	35%	UniProt GenBank	Glycosyltransferase	cmmGIV	Streptomyces griseus subsp. griseus
27	D7BZR5_STRBB (D7BZR5)	3e-42	177	35%	UniProt GenBank	Glycosyl transferase, NDP-D-desosamine: 3-L-mycarosyl erythronolide B	SBI_06850	Streptomyces bingchenggensis (strain BCW-1)
28	Q9L9F5_STRSH (Q9L9F5)	4e-41	173	36%	UniProt GenBank	NovM	novM	Streptomyces spheroides Streptomyces caeruleus
29	D8I4I4_AMYMU (D8I4I4)	5e-40	170	34%	UniProt GenBank	Putative glycosyl transferase	AMED_5398	Amycolatopsis mediterranei (strain U-32)
30	Q194Q0_STRAA (Q194Q0)	5e-40	169	34%	UniProt GenBank	Glycosyltransferase	mtmGIV	Streptomyces argillaceus
31	E8S036_MICSL (E8S036)	1e-39	168	37%	UniProt GenBank	Putative uncharacterized protein	ML5_4680	Micromonospora sp. (strain L5)
32	Q70J67_STRGR (Q70J67)	3e-39	167	36%	UniProt GenBank	Glycosyltransferase	cmmGII	Streptomyces griseus subsp. griseus
33	Q9ZGH7_9ACTO (Q9ZGH7)	5e-39	166	33%	UniProt GenBank	Glycosyl transferase	desVII	Streptomyces venezuelae
34	D2AY79_STRRD (D2AY79)	7e-39	166	39%	UniProt GenBank	IroB	Sros_4185	Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
35	D9SZA9_MICAI (D9SZA9)	8e-39	166	36%	UniProt GenBank	Putative uncharacterized protein	Micau_3719	Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
36	Q0R4P9_STRAT (Q0R4P9)	9e-39	166	34%	UniProt GenBank	ChlC7		Streptomyces antibioticus
37	O87831_STRAT (O87831)	1e-38	165	34%	UniProt GenBank	Glycosyltransferase	oleG2	Streptomyces antibioticus
38	D8I4J6_AMYMU (D8I4J6)	3e-38	164	34%	UniProt GenBank	Putative glycosyl transferase	AMED_5410	Amycolatopsis mediterranei (strain U-32)
39	D6MSX4_9ACTO (D6MSX4)	3e-38	164	32%	UniProt GenBank	SsfS6	ssfS6	Streptomyces sp. SF2575
40	B3TMN6_9ACTO (B3TMN6)	3e-38	164	33%	UniProt GenBank	Glycosyltransferase	KijA4	Actinomadura kijaniata
41	Q0R4N0_STRAT (Q0R4N0)	4e-38	164	33%	UniProt GenBank	ChlC6		Streptomyces antibioticus
42	D7B025_NOCDD (D7B025)	4e-38	164	34%	UniProt GenBank	Putative uncharacterized protein	Ndas_4727	Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488) Actinomadura dassonvillei
43	A8Y8I2_STRAM (A8Y8I2)	1e-37	162	34%	UniProt GenBank	Putative glycosyltransferase	srm18	Streptomyces ambofaciens
44	P95834_STRPE (P95834)	2e-37	161	31%	UniProt GenBank	Putative baumycin biosynthesis protein	dnrH	Streptomyces peucetius
45	D1GLU2_9ACTO (D1GLU2)	5e-37	160	32%	UniProt GenBank	Glycosyltransferase	slgG	Streptomyces lydicus
46	A4GV85_9ACTO (A4GV85)	6e-37	159	33%	UniProt GenBank	Glycosyltransferase	holC	Streptomyces rufochromogenes
47	D4QF41_9ACTO (D4QF41)	7e-37	159	33%	UniProt GenBank	Rhamnosyltransferase	lipB1	Streptomyces sp. SANK 60405
48	Q8KRX7_9ACTO (Q8KRX7)	7e-37	159	33%	UniProt GenBank	NbmD	nbmD	Streptomyces narbonensis
49	B3TMP7_9ACTO (B3TMP7)	8e-37	159	33%	UniProt GenBank	Glycosyltransferase	KijC3	Actinomadura kijaniata
50	D7B009_NOCDD (D7B009)	8e-37	159	33%	UniProt GenBank	Putative uncharacterized protein	Ndas_4711	Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488) Actinomadura dassonvillei
51	B3TMP5_9ACTO (B3TMP5)	1e-36	158	33%	UniProt GenBank	Glycosyltransferase	KijC1	Actinomadura kijaniata
52	Q935Z8_9ACTO (Q935Z8)	2e-36	157	31%	UniProt GenBank	RdmH	rdmH	Streptomyces purpurascens
53	Q2P9Y9_9ACTO (Q2P9Y9)	3e-36	157	34%	UniProt GenBank	Glycosyl transferase	stfG	Streptomyces steffisburgensis
54	E8RWS4_MICSL (E8RWS4)	6e-36	156	31%	UniProt GenBank	Putative uncharacterized protein	ML5_4413	Micromonospora sp. (strain L5)
55	D9T2A5_MICAI (D9T2A5)	6e-36	156	31%	UniProt GenBank	Putative uncharacterized protein	Micau_4008	Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
56	D6AXP3_9ACTO (D6AXP3)	7e-36	156	33%	UniProt GenBank	C-glycosyltransferase SaqGT5	SSHG_05335	Streptomyces albus J1074
57	Q5SFB5_STRBI (Q5SFB5)	9e-36	155	32%	UniProt GenBank	Putative chalcose glycosyltransferase	chmCIII	Streptomyces bikiniensis
58	E3IV35_FRASU (E3IV35)	1e-35	155	32%	UniProt GenBank	Putative uncharacterized protein	FraEuI1c_2005	Frankia sp. (strain EuI1c)
59	Q9F8U7_9ACTO (Q9F8U7)	1e-35	155	34%	UniProt GenBank	Glycosyl transferase	couM	Streptomyces rishiriensis
60	D7AZB3_NOCDD (D7AZB3)	2e-35	155	33%	UniProt GenBank	Putative uncharacterized protein	Ndas_4707	Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488) Actinomadura dassonvillei
61	C0JWA3_9ACTO (C0JWA3)	2e-35	155	32%	UniProt GenBank	PokGT1	pokGT1	Streptomyces diastatochromogenes
62	Q76KZ6_STRHA (Q76KZ6)	2e-35	154	29%	UniProt GenBank	Glycosyltransferase	vinC	Streptomyces halstedii
63	B5L6J8_MICCH (B5L6J8)	2e-35	154	32%	UniProt GenBank	Glycosyltransferase		Micromonospora chalcea
64	E4N0M1_KITSK (E4N0M1)	3e-35	154	36%	UniProt GenBank	Putative glycosyltransferase	KSE_59350	Kitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054) Streptomyces setae
65	Q331Q0_9ACTO (Q331Q0)	5e-35	153	31%	UniProt GenBank	Chalcosyltransferase	gerTII	Streptomyces sp. KCTC 0041BP
66	Q52V43_9ACTO (Q52V43)	6e-35	153	36%	UniProt GenBank	Glycosyltransferase		Streptomyces aizunensis
67	Q9ZA43_STRVN (Q9ZA43)	7e-35	152	30%	UniProt GenBank	Putative glycosyl transferase	gra-orf14	Streptomyces violaceoruber
68	B4VEK6_9ACTO (B4VEK6)	9e-35	152	31%	UniProt GenBank	Chalcosyltransferase	SSAG_06216	Streptomyces sp. Mg1
69	Q9RN63_STRNO (Q9RN63)	1e-34	152	33%	UniProt GenBank	Putative glycosyl transferase	snogE	Streptomyces nogalater
70	A4F7H2_SACEN (A4F7H2)	2e-34	151	33%	UniProt GenBank	Putative glucosyltransferase	iroB SACE_0652	Saccharopolyspora erythraea (strain NRRL 23338)	2.4.1.- niceE keggE
71	A4GV89_9ACTO (A4GV89)	2e-34	151	33%	UniProt GenBank	Glycosyltransferase	holN	Streptomyces sp. FU107
72	A4FK43_SACEN (A4FK43)	2e-34	151	33%	UniProt GenBank	Putative glycosyl transferase, related to UDP-glucuronosyltransferase	iroB SACE_5174	Saccharopolyspora erythraea (strain NRRL 23338)
73	Q9RIP9_STRNO (Q9RIP9)	2e-34	151	34%	UniProt GenBank	SnogZ	snogZ	Streptomyces nogalater
74	B3TMR7_9ACTO (B3TMR7)	2e-34	151	33%	UniProt GenBank	Glycosyltransferase	KijD9	Actinomadura kijaniata
75	C4NCL8_9ACTO (C4NCL8)	2e-34	151	32%	UniProt GenBank	Rhamnosyltransferase	cpz31	Streptomyces sp. MK730-62F2
76	Q0H2X6_9ACTO (Q0H2X6)	2e-34	150	33%	UniProt GenBank	Putative O-glycosyltransferase	atG1	Actinomadura melliaura
77	E3IZG9_FRASU (E3IZG9)	3e-34	150	31%	UniProt GenBank	Putative uncharacterized protein	FraEuI1c_4748	Frankia sp. (strain EuI1c)
78	Q194P5_STRAA (Q194P5)	3e-34	150	32%	UniProt GenBank	Glycosyltransferase	mtmGI	Streptomyces argillaceus
79	D8I4J7_AMYMU (D8I4J7)	4e-34	150	35%	UniProt GenBank	Putative glycosyl transferase	AMED_5411	Amycolatopsis mediterranei (strain U-32)
80	A1C188_9ACTO (A1C188)	4e-34	150	32%	UniProt GenBank	L-rhamnosyltransferase		Streptomyces echinatus
81	E3T492_9ACTO (E3T492)	5e-34	150	30%	UniProt GenBank	Putative glycosyl transferase	gra-orf14	Streptomyces vietnamensis
82	Q2I780_9ACTO (Q2I780)	6e-34	149	31%	UniProt GenBank	PlaA6	plaA6 STTU_1431	Streptomyces sp. Tu6071
83	D9VBX2_9ACTO (D9VBX2)	7e-34	149	32%	UniProt GenBank	Putative uncharacterized protein	SSMG_03360	Streptomyces sp. AA4
84	D7AZA6_NOCDD (D7AZA6)	1e-33	148	33%	UniProt GenBank	Putative uncharacterized protein	Ndas_4700	Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488) Actinomadura dassonvillei
85	B5L6L9_MICCH (B5L6L9)	2e-33	147	34%	UniProt GenBank	Glycosyltransferase		Micromonospora chalcea
86	B5L6L8_MICCH (B5L6L8)	3e-33	147	31%	UniProt GenBank	Glycosyltransferase		Micromonospora chalcea
87	Q53881_STRS5 (Q53881)	4e-33	147	31%	UniProt GenBank	Glycosyltransferase	dauH	Streptomyces sp. (strain C5)
88	A0ACI7_STRAM (A0ACI7)	6e-33	146	30%	UniProt GenBank	Putative glycosyltransferase	SAMR0481	Streptomyces ambofaciens ATCC 23877
89	Q83WE1_MICGR (Q83WE1)	6e-33	146	32%	UniProt GenBank	Glycosyltransferase	mycB	Micromonospora griseorubida
90	A8WDM7_9ACTO (A8WDM7)	7e-33	146	32%	UniProt GenBank	Glycosyltransferase		Streptomyces eurythermus
91	D7B013_NOCDD (D7B013)	9e-33	145	33%	UniProt GenBank	Putative uncharacterized protein	Ndas_4715	Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488) Actinomadura dassonvillei
92	P95747_STRFR (P95747)	1e-32	145	34%	UniProt GenBank	Glycosyltransferase	tylMII(orf2*)	Streptomyces fradiae Streptomyces roseoflavus
93	D8HZA4_AMYMU (D8HZA4)	1e-32	145	31%	UniProt GenBank	DNTP-hexose glycosyl transferase	AMED_0639	Amycolatopsis mediterranei (strain U-32)
94	O52563_AMYMD (O52563)	1e-32	145	31%	UniProt GenBank	Putative dNTP-hexose glycosyltransferase		Amycolatopsis mediterranei Nocardia mediterranei
95	D7BZT2_STRBB (D7BZT2)	2e-32	145	34%	UniProt GenBank	IroB	SBI_06867	Streptomyces bingchenggensis (strain BCW-1)
96	A8M6E3_SALAI (A8M6E3)	2e-32	144	31%	UniProt GenBank	Putative uncharacterized protein	Sare_1263	Salinispora arenicola (strain CNS-205)
97	D7AZA5_NOCDD (D7AZA5)	2e-32	144	34%	UniProt GenBank	Putative uncharacterized protein	Ndas_4699	Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488) Actinomadura dassonvillei
98	B5G890_9ACTO (B5G890)	2e-32	144	29%	UniProt GenBank	Glycosyltransferase family 28 domain-containing protein	SSBG_00498	Streptomyces sp. SPB74
99	D7B014_NOCDD (D7B014)	3e-32	144	32%	UniProt GenBank	Putative uncharacterized protein	Ndas_4716	Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488) Actinomadura dassonvillei
100	A8Y8I1_STRAM (A8Y8I1)	3e-32	144	29%	UniProt GenBank	Probable glycosyltransferase	srm17	Streptomyces ambofaciens

accession

alignment

Evalue

Score

Ident.

link

information

pubmed

Q2HR28_9ACTO
(Q2HR28)

0.0

761

100%

Product: Putative O-glycosyltransferase
Gene: schS9
Organism: Streptomyces sp. SCC 2136

1uniprot
Angucyclines Sch 47554 and Sch 47555 from Streptomyces sp. SCC-2136: Cloning, Sequencing, and Characterization.(Mol. Cells) [2006]

2uniprot
Molecular cloning and characterization of biosynthetic genes cluster of Sch 47554 from Streptomyces sp. SCC 2136. [2004]

Q9RP99_STRFR
(Q9RP99)

1e-116

422

59%

Product: Glycosyl transferase
Gene: urdGT1c
Organism: Streptomyces fradiae
Streptomyces roseoflavus

1uniprot[Pubmed] 10658661 [Medline] 20121748
Two new tailoring enzymes, a glycosyltransferase and an oxygenase, involved in biosynthesis of the angucycline antibiotic urdamycin A in Streptomyces fradiae Tu2717.(Microbiology) [2000]

Q9RPA1_STRFR
(Q9RPA1)

1e-114

418

59%

Product: Glycosyl transferase
Gene: urdGT1b
Organism: Streptomyces fradiae
Streptomyces roseoflavus

D7BZS3_STRBB
(D7BZS3)

1e-111

407

56%

Product: Glycosyl transferase, NDP-D-desosamine: 3-L-mycarosyl erythronolide B
Gene: SBI_06858
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

C4NYL1_9ACTO
(C4NYL1)

1e-111

407

58%

Product: SaqGT4
Gene: saqGT4
Organism: Micromonospora sp. Tu 6368

[pubmed all]
1uniprot[Pubmed] 17497146 A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]
2uniprot[Pubmed] 19384899 Cloning and sequencing of the biosynthetic gene cluster for saquayamycin z and galtamycin B and the elucidation of the assembly of their saccharide chains.(Chembiochem) [2009]

Q9ZGB8_STRCY
(Q9ZGB8)

1e-105

387

55%

Product: Glycosyl transferase homolog
Gene: lanGT1
Organism: Streptomyces cyanogenus

1uniprot[Pubmed] 9933932 [Medline] 99132695
Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin biosynthesis.(FEMS Microbiol. Lett.) [1999]

C4NYL0_9ACTO
(C4NYL0)

1e-105

385

54%

Product: SaqGT3
Gene: saqGT3
Organism: Micromonospora sp. Tu 6368

[pubmed all]
1uniprot[Pubmed] 17497146 A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]
2uniprot[Pubmed] 19384899 Cloning and sequencing of the biosynthetic gene cluster for saquayamycin z and galtamycin B and the elucidation of the assembly of their saccharide chains.(Chembiochem) [2009]

A4GV88_9ACTO
(A4GV88)

3e-99

367

50%

Product: Glycosyltransferase
Gene: holL
Organism: Streptomyces sp. Tu1156

1uniprot[Pubmed] 17497146
A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]

Q6QR18_STRGL
(Q6QR18)

1e-96

357

55%

Product: Glycosyl transferase
Gene
Organism: Streptomyces globisporus

1uniprot[Pubmed] 15123249
Generation of new landomycins by combinatorial biosynthetic manipulation of the LndGT4 gene of the landomycin E cluster in S. globisporus.(Chem. Biol.) [2004]

D7BZS5_STRBB
(D7BZS5)

3e-89

333

49%

Product: IroB
Gene: SBI_06860
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

A4GV86_9ACTO
(A4GV86)

7e-85

318

46%

Product: Glycosyltransferase
Gene: holA
Organism: Streptomyces sp. FU107

1uniprot[Pubmed] 17497146
A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]

Q9ZGB4_STRCY
(Q9ZGB4)

2e-83

314

49%

Product: Glycosyl transferase homolog
Gene: lanGT3
Organism: Streptomyces cyanogenus

Q4JHR2_9PSEU
(Q4JHR2)

2e-58

231

37%

Product: BusG
Gene: busG
Organism: Saccharopolyspora pogona

1uniprot[Pubmed] 16179985
Butenyl-spinosyns, a natural example of genetic engineering of antibiotic biosynthetic genes.(J. Ind. Microbiol. Biotechnol.) [2006]

Q9ALM8_9PSEU
(Q9ALM8)

3e-55

220

35%

Product: Probable NDP-rhamnosyltransferase
Gene: spnG
Organism: Saccharopolyspora spinosa

1uniprot[Pubmed] 11358695 [Medline] 21257765
Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa.(Chem. Biol.) [2001]

D7BZR2_STRBB
(D7BZR2)

1e-54

218

42%

Product: Glycosyl transferase, NDP-D-desosamine: 3-L-mycarosyl erythronolide B
Gene: SBI_06847
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

C0JWA0_9ACTO
(C0JWA0)

5e-52

209

39%

Product: PokGT2
Gene: pokGT2
Organism: Streptomyces diastatochromogenes

1uniprot[Pubmed] 19266534
Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009]

D8I4K4_AMYMU
(D8I4K4)

3e-49

200

35%

Product: Putative glycosyl transferase
Gene: AMED_5418
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

D8I4K0_AMYMU
(D8I4K0)

4e-48

196

35%

Product: Putative glycosyl transferase
Gene: AMED_5414
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

Q194P9_STRAA
(Q194P9)

6e-48

196

36%

Product: Glycosyltransferase
Gene: mtmGIII
Organism: Streptomyces argillaceus

[pubmed all]
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]

Q4R0L9_STRCX
(Q4R0L9)

6e-46

189

36%

Product: ChaGT1 protein
Gene: chaGT1
Organism: Streptomyces chartreusis

1uniprot[Pubmed] 15911378
Biosynthesis of the antitumor agent chartreusin involves the oxidative rearrangement of an anthracyclic polyketide.(Chem. Biol.) [2005]

D8I4J9_AMYMU
(D8I4J9)

2e-45

187

36%

Product: Putative glycosyl transferase
Gene: AMED_5413
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

Q8GHC2_9ACTO
(Q8GHC2)

3e-43

180

37%

Product: Glycosyltransferase
Gene: cloM
Organism: Streptomyces roseochromogenes subsp. oscitans

1uniprot[Pubmed] 12480894 [Medline] 22368916
Molecular cloning and sequence analysis of the clorobiocin biosynthetic gene cluster: new insights into the biosynthesis of aminocoumarin antibiotics.(Microbiology) [2002]

D7BZR5_STRBB
(D7BZR5)

3e-42

177

35%

Product: Glycosyl transferase, NDP-D-desosamine: 3-L-mycarosyl erythronolide B
Gene: SBI_06850
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

Q9L9F5_STRSH
(Q9L9F5)

4e-41

173

36%

Product: NovM
Gene: novM
Organism: Streptomyces spheroides
Streptomyces caeruleus

1uniprot[Pubmed] 10770754 [Medline] 20233587
Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891.(Antimicrob. Agents Chemother.) [2000]

D8I4I4_AMYMU
(D8I4I4)

5e-40

170

34%

Product: Putative glycosyl transferase
Gene: AMED_5398
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

Q194Q0_STRAA
(Q194Q0)

5e-40

169

34%

Product: Glycosyltransferase
Gene: mtmGIV
Organism: Streptomyces argillaceus

[pubmed all]
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]

Q9ZGH7_9ACTO
(Q9ZGH7)

5e-39

166

33%

Product: Glycosyl transferase
Gene: desVII
Organism: Streptomyces venezuelae

1uniprot[Pubmed] 9770448 [Medline] 98445333
A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity.(Proc. Natl. Acad. Sci. U.S.A.) [1998]

D2AY79_STRRD
(D2AY79)

7e-39

166

39%

Product: IroB
Gene: Sros_4185
Organism: Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)

1uniprot
Complete genome sequence of Streptosporangium roseum type strain (NI 9100T).(Stand. Genomic Sci.) [2010]

Q0R4P9_STRAT
(Q0R4P9)

9e-39

166

34%

Product: ChlC7
Gene
Organism: Streptomyces antibioticus

1uniprot[Pubmed] 16793515
Genetic characterization of the chlorothricin gene cluster as a model for spirotetronate antibiotic biosynthesis.(Chem. Biol.) [2006]

O87831_STRAT
(O87831)

1e-38

165

34%

Product: Glycosyltransferase
Gene: oleG2
Organism: Streptomyces antibioticus

1uniprot[Pubmed] 9749673 [Medline] 98420102
Analysis of a Streptomyces antibioticus chromosomal region involved in oleandomycin biosynthesis, which encodes two glycosyltransferases responsible for glycosylation of the macrolactone ring.(Mol. Gen. Genet.) [1998]

D8I4J6_AMYMU
(D8I4J6)

3e-38

164

34%

Product: Putative glycosyl transferase
Gene: AMED_5410
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

D6MSX4_9ACTO
(D6MSX4)

3e-38

164

32%

Product: SsfS6
Gene: ssfS6
Organism: Streptomyces sp. SF2575

1uniprot[Pubmed] 19908837
Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.(J. Am. Chem. Soc.) [2009]

B3TMN6_9ACTO
(B3TMN6)

3e-38

164

33%

Product: Glycosyltransferase
Gene: KijA4
Organism: Actinomadura kijaniata

1uniprot[Pubmed] 17985890
Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007]

Q0R4N0_STRAT
(Q0R4N0)

4e-38

164

33%

Product: ChlC6
Gene
Organism: Streptomyces antibioticus

1uniprot[Pubmed] 16793515
Genetic characterization of the chlorothricin gene cluster as a model for spirotetronate antibiotic biosynthesis.(Chem. Biol.) [2006]

D7B025_NOCDD
(D7B025)

4e-38

164

34%

Product: Putative uncharacterized protein
Gene: Ndas_4727
Organism: Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei

1uniprot
Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010]

A8Y8I2_STRAM
(A8Y8I2)

1e-37

162

34%

Product: Putative glycosyltransferase
Gene: srm18
Organism: Streptomyces ambofaciens

1uniprot
Organization of the biosynthetic gene cluster for the macrolide antibiotic spiramycin in Streptomyces ambofaciens.(Microbiology (Mosc.)) [2007]

P95834_STRPE
(P95834)

2e-37

161

31%

Product: Putative baumycin biosynthesis protein
Gene: dnrH
Organism: Streptomyces peucetius

[pubmed all]
1uniprot[Pubmed] 8955419 [Medline] 97113559 Enhanced antibiotic production by manipulation of the Streptomyces peucetius dnrH and dnmT genes involved in doxorubicin (adriamycin) biosynthesis.(J. Bacteriol.) [1996]
2uniprot[Pubmed] 9864344 [Medline] 99084971 Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene.(J. Bacteriol.) [1999]

D1GLU2_9ACTO
(D1GLU2)

5e-37

160

32%

Product: Glycosyltransferase
Gene: slgG
Organism: Streptomyces lydicus

1uniprot
Deciphering biosynthesis of the RNA polymerase inhibitor streptolydigin and generation of glycosylated derivatives.(Chem. Biol.) [2009]

A4GV85_9ACTO
(A4GV85)

6e-37

159

33%

Product: Glycosyltransferase
Gene: holC
Organism: Streptomyces rufochromogenes

1uniprot[Pubmed] 17497146
A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]

D4QF41_9ACTO
(D4QF41)

7e-37

159

33%

Product: Rhamnosyltransferase
Gene: lipB1
Organism: Streptomyces sp. SANK 60405

1uniprot[Pubmed] 20043306
The biosynthesis of liposidomycin-like A-90289 antibiotics featuring a new type of sulfotransferase.(Chembiochem) [2010]

B3TMP7_9ACTO
(B3TMP7)

8e-37

159

33%

Product: Glycosyltransferase
Gene: KijC3
Organism: Actinomadura kijaniata

1uniprot[Pubmed] 17985890
Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007]

D7B009_NOCDD
(D7B009)

8e-37

159

33%

Product: Putative uncharacterized protein
Gene: Ndas_4711
Organism: Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei

1uniprot
Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010]

B3TMP5_9ACTO
(B3TMP5)

1e-36

158

33%

Product: Glycosyltransferase
Gene: KijC1
Organism: Actinomadura kijaniata

1uniprot[Pubmed] 17985890
Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007]

Q2P9Y9_9ACTO
(Q2P9Y9)

3e-36

157

34%

Product: Glycosyl transferase
Gene: stfG
Organism: Streptomyces steffisburgensis

1uniprot[Pubmed] 16751529
Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin.(Appl. Environ. Microbiol.) [2006]

Q5SFB5_STRBI
(Q5SFB5)

9e-36

155

32%

Product: Putative chalcose glycosyltransferase
Gene: chmCIII
Organism: Streptomyces bikiniensis

1uniprot[Pubmed] 15561847
Chalcomycin biosynthesis gene cluster from Streptomyces bikiniensis: novel features of an unusual ketolide produced through expression of the chm polyketide synthase in Streptomyces fradiae.(Antimicrob. Agents Chemother.) [2004]

Q9F8U7_9ACTO
(Q9F8U7)

1e-35

155

34%

Product: Glycosyl transferase
Gene: couM
Organism: Streptomyces rishiriensis

1uniprot[Pubmed] 11036020 [Medline] 20493109
Identification of the coumermycin A(1) biosynthetic gene cluster of Streptomyces rishiriensis DSM 40489.(Antimicrob. Agents Chemother.) [2000]

D7AZB3_NOCDD
(D7AZB3)

2e-35

155

33%

Product: Putative uncharacterized protein
Gene: Ndas_4707
Organism: Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei

1uniprot
Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010]

C0JWA3_9ACTO
(C0JWA3)

2e-35

155

32%

Product: PokGT1
Gene: pokGT1
Organism: Streptomyces diastatochromogenes

1uniprot[Pubmed] 19266534
Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009]

Q76KZ6_STRHA
(Q76KZ6)

2e-35

154

29%

Product: Glycosyltransferase
Gene: vinC
Organism: Streptomyces halstedii

1uniprot[Pubmed] 15112997
Cloning, sequencing, and functional analysis of the biosynthetic gene cluster of macrolactam antibiotic vicenistatin in Streptomyces halstedii.(Chem. Biol.) [2004]

B5L6J8_MICCH
(B5L6J8)

2e-35

154

32%

Product: Glycosyltransferase
Gene
Organism: Micromonospora chalcea

1uniprot[Pubmed] 18586939
Cloning and characterization of the tetrocarcin A gene cluster from Micromonospora chalcea NRRL 11289 reveals a highly conserved strategy for tetronate biosynthesis in spirotetronate antibiotics.(J. Bacteriol.) [2008]

E4N0M1_KITSK
(E4N0M1)

3e-35

154

36%

Product: Putative glycosyltransferase
Gene: KSE_59350
Organism: Kitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054)
Streptomyces setae

1uniprot[Pubmed] 21059706
Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary snapshot of the family Streptomycetaceae.(DNA Res.) [2010]

Q331Q0_9ACTO
(Q331Q0)

5e-35

153

31%

Product: Chalcosyltransferase
Gene: gerTII
Organism: Streptomyces sp. KCTC 0041BP

1uniprot[Pubmed] 17053005
Biosynthesis of dTDP-6-deoxy-beta-D-allose, biochemical characterization of dTDP-4-keto-6-deoxyglucose reductase (GerKI) from Streptomyces sp. KCTC 0041BP.(Glycobiology) [2007]

2uniprot
Cloning and characterization of a gene cluster for the production of the polyketide macrolide antibiotic dihydrochalcomycin in Streptomyces sp. KCTC 0041BP.(J. Microbiol. Biotechnol.) [2006]

Q52V43_9ACTO
(Q52V43)

6e-35

153

36%

Product: Glycosyltransferase
Gene
Organism: Streptomyces aizunensis

1uniprot[Pubmed] 15844935
Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example.(J. Nat. Prod.) [2005]

Q9ZA43_STRVN
(Q9ZA43)

7e-35

152

30%

Product: Putative glycosyl transferase
Gene: gra-orf14
Organism: Streptomyces violaceoruber

[pubmed all]
1uniprot[Pubmed] 2583128 [Medline] 90060034 Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber Tu22.(EMBO J.) [1989]
2uniprot[Pubmed] 7476861 [Medline] 96027933 Identification of Streptomyces violaceoruber Tu22 genes involved in the biosynthesis of granaticin.(Mol. Gen. Genet.) [1995]
3uniprot[Pubmed] 9831526 [Medline] 99051446 The granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tu22: sequence analysis and expression in a heterologous host.(Chem. Biol.) [1998]

Q9RN63_STRNO
(Q9RN63)

1e-34

152

33%

Product: Putative glycosyl transferase
Gene: snogE
Organism: Streptomyces nogalater

[pubmed all]
1uniprot[Pubmed] 9349712 [Medline] 98007868 Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.(Mol. Gen. Genet.) [1997]
2uniprot[Pubmed] 10639368 [Medline] 20106987 Identification of a cyclase gene dictating the C-9 stereochemistry of anthracyclines from Streptomyces nogalater.(Antimicrob. Agents Chemother.) [2000]

A4F7H2_SACEN
(A4F7H2)

2e-34

151

33%

Product: Putative glucosyltransferase
Gene: iroB
SACE_0652
Organism: Saccharopolyspora erythraea (strain NRRL 23338)

1uniprot[Pubmed] 17369815
Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007]

A4GV89_9ACTO
(A4GV89)

2e-34

151

33%

Product: Glycosyltransferase
Gene: holN
Organism: Streptomyces sp. FU107

1uniprot[Pubmed] 17497146
A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]

A4FK43_SACEN
(A4FK43)

2e-34

151

33%

Product: Putative glycosyl transferase, related to UDP-glucuronosyltransferase
Gene: iroB
SACE_5174
Organism: Saccharopolyspora erythraea (strain NRRL 23338)

1uniprot[Pubmed] 17369815
Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007]

Q9RIP9_STRNO
(Q9RIP9)

2e-34

151

34%

Product: SnogZ
Gene: snogZ
Organism: Streptomyces nogalater

[pubmed all]
1uniprot[Pubmed] 8668120 [Medline] 96242142 A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.(Mol. Gen. Genet.) [1996]
2uniprot[Pubmed] 9349712 [Medline] 98007868 Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.(Mol. Gen. Genet.) [1997]
3uniprot[Pubmed] 8760909 [Medline] 96349102 Production of hybrid anthracycline antibiotics by heterologous expression of Streptomyces nogalater nogalamycin biosynthesis genes.(Microbiology) [1996]

B3TMR7_9ACTO
(B3TMR7)

2e-34

151

33%

Product: Glycosyltransferase
Gene: KijD9
Organism: Actinomadura kijaniata

1uniprot[Pubmed] 17985890
Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007]

C4NCL8_9ACTO
(C4NCL8)

2e-34

151

32%

Product: Rhamnosyltransferase
Gene: cpz31
Organism: Streptomyces sp. MK730-62F2

1uniprot[Pubmed] 19351877
Identification and manipulation of the caprazamycin gene cluster leads to new simplified liponucleoside antibiotics and gives insights into the biosynthetic pathway.(J. Biol. Chem.) [2009]

Q0H2X6_9ACTO
(Q0H2X6)

2e-34

150

33%

Product: Putative O-glycosyltransferase
Gene: atG1
Organism: Actinomadura melliaura

1uniprot[Pubmed] 16873021
Deciphering indolocarbazole and enediyne aminodideoxypentose biosynthesis through comparative genomics: insights from the AT2433 biosynthetic locus.(Chem. Biol.) [2006]

Q194P5_STRAA
(Q194P5)

3e-34

150

32%

Product: Glycosyltransferase
Gene: mtmGI
Organism: Streptomyces argillaceus

[pubmed all]
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]

D8I4J7_AMYMU
(D8I4J7)

4e-34

150

35%

Product: Putative glycosyl transferase
Gene: AMED_5411
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

Q2I780_9ACTO
(Q2I780)

6e-34

149

31%

Product: PlaA6
Gene: plaA6
STTU_1431
Organism: Streptomyces sp. Tu6071

1uniprot[Pubmed] 16632249
Biosynthesis of the terpene phenalinolactone in Streptomyces sp. Tu6071: analysis of the gene cluster and generation of derivatives.(Chem. Biol.) [2006]

D7AZA6_NOCDD
(D7AZA6)

1e-33

148

33%

Product: Putative uncharacterized protein
Gene: Ndas_4700
Organism: Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei

1uniprot
Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010]

B5L6L9_MICCH
(B5L6L9)

2e-33

147

34%

Product: Glycosyltransferase
Gene
Organism: Micromonospora chalcea

B5L6L8_MICCH
(B5L6L8)

3e-33

147

31%

Product: Glycosyltransferase
Gene
Organism: Micromonospora chalcea

Q53881_STRS5
(Q53881)

4e-33

147

31%

Product: Glycosyltransferase
Gene: dauH
Organism: Streptomyces sp. (strain C5)

1uniprot[Pubmed] 8655529 [Medline] 96236066
Cloning, sequencing, and analysis of aklaviketone reductase from Streptomyces sp. strain C5.(J. Bacteriol.) [1996]

A0ACI7_STRAM
(A0ACI7)

6e-33

146

30%

Product: Putative glycosyltransferase
Gene: SAMR0481
Organism: Streptomyces ambofaciens ATCC 23877

1uniprot[Pubmed] 16956972
Evolution of the terminal regions of the Streptomyces linear chromosome.(Mol. Biol. Evol.) [2006]

2uniprot
Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877.(Microbiology (Mosc.)) [2006]

Q83WE1_MICGR
(Q83WE1)

6e-33

146

32%

Product: Glycosyltransferase
Gene: mycB
Organism: Micromonospora griseorubida

1uniprot[Pubmed] 12583909 [Medline] 22472038
Organization of the biosynthetic gene cluster for the polyketide macrolide mycinamicin in Micromonospora griseorubida.(FEMS Microbiol. Lett.) [2003]

D7B013_NOCDD
(D7B013)

9e-33

145

33%

Product: Putative uncharacterized protein
Gene: Ndas_4715
Organism: Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei

1uniprot
Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010]

P95747_STRFR
(P95747)

1e-32

145

34%

Product: Glycosyltransferase
Gene: tylMII(orf2*)
Organism: Streptomyces fradiae
Streptomyces roseoflavus

1uniprot[Pubmed] 9031628 [Medline] 97183662
Analysis of four tylosin biosynthetic genes from the tylLM region of Streptomyces fradiae.(Gene) [1997]

D8HZA4_AMYMU
(D8HZA4)

1e-32

145

31%

Product: DNTP-hexose glycosyl transferase
Gene: AMED_0639
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

O52563_AMYMD
(O52563)

1e-32

145

31%

Product: Putative dNTP-hexose glycosyltransferase
Gene
Organism: Amycolatopsis mediterranei
Nocardia mediterranei

[pubmed all]
1uniprot[Pubmed] 9512878 [Medline] 98174059 Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699.(Chem. Biol.) [1998]
2uniprot[Pubmed] 9497318 [Medline] 98165773 3-amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the formation of the precursor of mC7N units in rifamycin and related antibiotics.(J. Biol. Chem.) [1998]
3uniprot[Pubmed] 11278540 [Medline] 21201076 Mutational analysis and reconstituted expression of the biosynthetic genes involved in the formation of 3-amino-5-hydroxybenzoic acid, the starter unit of rifamycin biosynthesis in amycolatopsis Mediterranei S699.(J. Biol. Chem.) [2001]

D7BZT2_STRBB
(D7BZT2)

2e-32

145

34%

Product: IroB
Gene: SBI_06867
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

D7AZA5_NOCDD
(D7AZA5)

2e-32

144

34%

Product: Putative uncharacterized protein
Gene: Ndas_4699
Organism: Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei

1uniprot
Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010]

D7B014_NOCDD
(D7B014)

3e-32

144

32%

Product: Putative uncharacterized protein
Gene: Ndas_4716
Organism: Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei

1uniprot
Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010]

100

A8Y8I1_STRAM
(A8Y8I1)

3e-32

144

29%

Product: Probable glycosyltransferase
Gene: srm17
Organism: Streptomyces ambofaciens

1uniprot
Organization of the biosynthetic gene cluster for the macrolide antibiotic spiramycin in Streptomyces ambofaciens.(Microbiology (Mosc.)) [2007]