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Rule : Para-aminobenzoate synthase component I (PABB)

Rule Description

ID NRULE_0161
Rule name PABB
Created 2013-02-26
Protein name
Protein name
Full
Para-aminobenzoate synthase component I
EC
EC 2.6.1.85
Synonym
Full
ADC synthase
Gene name pabB
Rule Trigger TIGRFAMs; TIGR00553; hit=1
OR
TIGRFAMs; TIGR01824; hit=1
Cross Reference
Gene Ontology
GO
GO:0046820, F:4-amino-4-deoxychorismate synthase activity, IEA:EC
GO:0016833, F:oxo-acid-lyase activity, IEA:InterPro
GO:0046656, P:folic acid biosynthetic process, IEA:UniProtKB-KW
GO:0046654, P:tetrahydrofolate biosynthetic process, IEA:UniProtKB-UniPathway
Enzyme and pathway databases
UniPathway
UPA00077, UER00149
Family and domain databases
InterPro
IPR005801, ADC_synthase
IPR019999, Anth_synth_I
IPR006805, Anth_synth_I_N
IPR015890, Chorismate-bd_C
IPR005802, Para-NH2Bz_synth_comp_1
IPR010118, Para-NH2Bz/anthranilate_synth
Pfam
PF04715, Anth_synt_I_N, 1
PF00425, Chorismate_bind, 1
PRINTS
PR00095, ANTSNTHASEI
TIGRFAMs
TIGR00553, pabB, 1
TIGR01824, PabB-clade2, 1
Feature Not assigned
General annotation
Function
Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine
Catalytic activity
Chorismate + L-glutamine = 4-amino-4- deoxychorismate + L-glutamate
Pathway
Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4- aminobenzoate from chorismate: step 1/2
Subunit structure
Consists of two non-identical chains: component I catalyzes the formation of ADC by binding chorismate and ammonia; component II provides the glutamine amidotransferase activity
Sequence similarities
Belongs to the anthranilate synthase component I family
Reference
P12679 Enterobacter aerogenes (Aerobacter aerogenes).
3057324
Evolution of aminobenzoate synthases: nucleotide sequences of Salmonella typhimurium and Klebsiella aerogenes pabB. (Mol Biol Evol. 1988)
2251281
p-Aminobenzoate synthesis in Escherichia coli: purification and characterization of PabB as aminodeoxychorismate synthase and enzyme X as aminodeoxychorismate lyase. (Proc Natl Acad Sci U S A. 1990)
P27629 Lactococcus lactis subsp. lactis (Streptococcus lactis).
8409921
Cloning, nucleotide sequence and expression in Streptomyces lividans and Escherichia coli of pabB from Lactococcus lactis subsp. lactis NCDO 496. (J Gen Microbiol. 1993)
2251281
p-Aminobenzoate synthesis in Escherichia coli: purification and characterization of PabB as aminodeoxychorismate synthase and enzyme X as aminodeoxychorismate lyase. (Proc Natl Acad Sci U S A. 1990)



Related Function

Function name
Folate biosynthesis

CDS

Data Download
Scientific name NBRC No. CDS Product name
Acaricomes phytoseiuli107788C501_08815hypothetical protein
Acaryochloris marina102967AM1_5363para-aminobenzoate synthase component I / anthranilate synthase
Acetobacter tropicalis101654ATPR_1727para-aminobenzoate synthase component I
Acidithiobacillus ferrooxidansLferr_0730para-aminobenzoate synthase, subunit I
Actinopolyspora iraqiensis103187ACTIR_063_00030para-aminobenzoate synthase component I
Actinosynnema mirum14064Amir_5650para-aminobenzoate synthase, subunit I
Alicyclobacillus acidocaldarius subsp. acidocaldarius15652Aaci_1357para-aminobenzoate synthase, subunit I
Alloiococcus otitis15545HMPREF9698_01161aminodeoxychorismate synthase, component I
Alteromonas macleodii102226MASE_09510P-aminobenzoate synthetase, component I
Amycolatopsis azurea14573C791_2329Para-aminobenzoate synthase, aminase component
Amycolatopsis mediterranei13415RAM_42400aminodeoxychorismate synthase component I
Aquimarina agarilytica107695AagaZ_020100007729anthranilate synthase
Ardenticatena maritimaARMA_0014para-aminobenzoate synthetase/4-amino-4-deoxychorismate lyase
Arthrobacter globiformis12137ARGLB_073_01200para-aminobenzoate synthase
Austwickia chelonae105200AUCHE_16_00230para-aminobenzoate synthase
Azorhizobium caulinodans14845AZC_1598para-aminobenzoate synthase
Bacillus amyloliquefaciens15535BAMF_00744-amino-4-deoxychorismate synthase (para-aminobenzoate synthase)
Bacillus atrophaeus13721BATRMS_24_00510para-aminobenzoate synthase subunit A
Bacillus cereus15305BC_0076Para-aminobenzoate synthase component I
Bacillus mycoides101228bmyco0001_560Para-aminobenzoate synthase component 1
Bacillus psychrosaccharolyticus101233WYK_205_00720para-aminobenzoate synthase component II
Bradyrhizobium diazoefficiens14792bll2092para-aminobenzoate synthase component I
Brevibacterium linens12170BlinB_010200013316para-aminobenzoate synthase
Caulobacter segnis15250Cseg_3450para-aminobenzoate synthase component I
Cellulophaga lytica14961Celly_3018Anthranilate synthase
Chitinispirillum alkaliphilumCHISP_1979Para-aminobenzoate synthase, aminase component
Chlorobaculum tepidum103806CT1712para-aminobenzoate synthetase, putative
Chlorobium limicola103803Clim_1992para-aminobenzoate synthase, subunit I
Chthoniobacter flavusCfE428DRAFT_5862para-aminobenzoate synthase, subunit I
Coraliomargarita akajimensisCaka_2392para-aminobenzoate synthase, subunit I
Corynebacterium ammoniagenes12612HMPREF0281_01617aminodeoxychorismate synthase, component I
Corynebacterium callunae15359H924_04680PARA-aminobenzoate synthase component I and II
Corynebacterium efficiens100395CE1059putative p-aminobenzoic acid synthase
Corynebacterium glutamicum12168Cgl0997Anthranilate/para-aminobenzoate synthases component I
Corynebacterium glutamicum12153KIQ_09655anthranilate/para-aminobenzoate synthase component I
Corynebacterium matruchotii15360HMPREF0299_5532aminodeoxychorismate synthase, component I
Corynebacterium terpenotabidum14764A606_02670para-aminobenzoate synthase component I/II
Cupriavidus metallidurans102507Rmet_2920Anthranilate/para-aminobenzoate synthase component I
Edwardsiella tarda105688ET1_05_01450para-aminobenzoate synthase component I
Enterobacter aerogenes13534EAE_22580aminodeoxychorismate synthase subunit I
Enterobacter cloacae subsp. cloacae13535ECL_01492aminodeoxychorismate synthase, subunit I
Enterobacter hormaechei105718HMPREF9086_2757para-aminobenzoate synthase
Escherichia coli3972EcolC_1821para-aminobenzoate synthase, subunit I
Escherichia coli13500WFL_09735aminodeoxychorismate synthase subunit I
Escherichia coli12713Y75_1809aminodeoxychorismate synthase, subunit I
Escherichia fergusonii102419EFER_1264aminodeoxychorismate synthase, subunit I
Escherichia hermannii105704EH105704_01_03030para-aminobenzoate synthase component I
Fusobacterium nucleatum subsp. NucleatumFN1730Para-aminobenzoate synthase component I
Geodermatophilus obscurus13315Gobs_2871para-aminobenzoate synthase, subunit I
Gordonia alkanivorans16433GOALK_117_00210para-aminobenzoate synthase
Gordonia amicalis100051GOAMI_12_00220para-aminobenzoate synthase
Gordonia hirsuta16056GOHSU_19_00330anthranilate synthase component I
Gordonia namibiensis108229GONAM_02_03280para-aminobenzoate synthase
Gordonia rhizosphera16068GORHZ_200_00240para-aminobenzoate synthase
Gordonia rubripertincta101908GORBP_075_00560para-aminobenzoate synthase
Gordonia terrae100016GOTRE_123_00590para-aminobenzoate synthase
Haloarcula vallismortis14741C437_10196para-aminobenzoate synthase component I
Halobacillus halophilus102448HBHAL_4860para-aminobenzoate synthase subunit I
Halobacterium sp.VNG_0384Ganthranilate synthase alpha chain
Halomonas elongata15536HELO_1738para-aminobenzoate synthase component I
Herpetosiphon aurantiacusHaur_2989para-aminobenzoate synthase, subunit I
Ignavibacterium album101810IALB_17344-amino-4-deoxychorismate lyase
Kineosphaera limosa100340KILIM_008_00140para-aminobenzoate synthase component I
Klebsiella pneumoniae14438KPR_3240
Klebsiella pneumoniae subsp. rhinoscleromatis105682HMPREF0484_2124aminodeoxychorismate synthase, component I
Kordia algicida100336KAOT1_07493hypothetical protein
Kribbella flavida14399Kfla_4134para-aminobenzoate synthase, subunit I
Kfla_5869para-aminobenzoate synthase, subunit I
Ktedonobacter racemiferKrac_5281para-aminobenzoate synthase, subunit I
Kyrpidia tusciae15312Btus_1115para-aminobenzoate synthase, subunit I
Labrenzia aggregata16684SIAM614_04270para-aminobenzoate synthase, component I
Lentisphaera araneosaLNTAR_17168para-aminobenzoate synthetase, putative
Leptospira interrogansLA_0110para-aminobenzoate synthase component I
Limnochorda pilosa110152LIP_3372aminobenzoate synthetase
Magnetospirillum gryphiswaldense15271MGR_0665Para-aminobenzoate synthase, component I
Marinomonas mediterranea103028Marme_3079para-aminobenzoate synthase, subunit I
Marivirga tractuosa15989Ftrac_0756Chorismate binding protein
Methylobacterium radiotolerans15690Mrad2831_1638para-aminobenzoate synthase, subunit I
Nocardiopsis dassonvillei14626Ndas_1766para-aminobenzoate synthase, subunit I
Ndas_2111para-aminobenzoate synthase, subunit I
Nostoc sp.alr3443p-aminobenzoic acid synthase
Ochrobactrum anthropi15819Oant_4261para-aminobenzoate synthase, subunit I
Ochrobactrum intermedium15820OINT_2001339para-aminobenzoate synthase, component I
Pelobacter propionicus103807Ppro_2808para-aminobenzoate synthase, subunit I
Phaeobacter gallaeciensis16654PGA1_c24550putative para-aminobenzoate synthase component 1
Photobacterium damselae subsp. damselae corrig.15633VDA_001838para-aminobenzoate synthase aminase component
Planctomyces brasiliensis103401Plabr_2374Anthranilate synthase
Propionibacterium avidum15671HMPREF9153_0598para-aminobenzoate synthase
Proteus mirabilis105697HMPREF0693_1233aminodeoxychorismate synthase, component I
Providencia alcalifaciens105687PROVALCAL_01851aminodeoxychorismate synthase, component I
Pseudomonas putida100650PP_2329para-aminobenzoate synthase, component I
Pseudomonas stutzeri14165PSTAB_1929para-aminobenzoate synthase, component I
Rahnella aquatilis105701Rahaq2_2917aminodeoxychorismate synthase, component I
Renibacterium salmoninarum15589RSal33209_1025para-aminobenzoate synthase
Rhizobium etli15573RHE_CH03550para-aminobenzoate synthase component I protein
Rhizobium sp.101917NGR_c28430para-aminobenzoate synthase, component I
Rhizobium tropici15247RTCIAT899_CH15060aminodeoxychorismate synthase, component I
Rhodobacter capsulatus16581RCAP_rcc02644para-aminobenzoate synthase, component I
Rhodobacter sphaeroides12203RSP_0817aminodeoxychorismate synthase, subunit I
Rhodococcus erythropolis100887RER_18480para-aminobenzoate synthase
Rhodococcus opacus108011ROP_61630para-aminobenzoate synthase
Roseobacter denitrificans15277RD1_3657para-aminobenzoate synthase, component I, putative
Roseobacter litoralis15278RLO149_c008050putative chorismate-binding protein
Rubrobacter xylanophilus100952Rxyl_0761aminodeoxychorismate synthase, subunit I
Saccharomonospora viridis12207Svir_32510aminodeoxychorismate synthase, component I
Saccharopolyspora erythraea13426SACE_0793para-aminobenzoate synthetase component I
SACE_4036putative para-aminobenzoic acid synthase
Saccharopolyspora spinosa15153SspiN1_010100016231para-aminobenzoate synthase
SspiN1_010100022915para-aminobenzoate synthase
SspiN1_010100041375aminodeoxychorismate synthase
Saccharothrix espanaensis15066BN6_50300para-aminobenzoate synthase
BN6_67720para-aminobenzoate synthase
Salinibacter ruberSRU_1685chorismate binding enzyme
Serratia odorifera102598HMPREF0758_3332aminodeoxychorismate synthase, component I
Shimwellia blattae105725EB105725_24_00300para-aminobenzoate synthase component I
Sphingobium japonicum101211SJA_C1-08130para-aminobenzoate synthetase component I
Sphingobium sp.103272SLG_37000para-aminobenzoate synthetase component I
Sphingomonas echinoides15742SechA1_010100012027para-aminobenzoate synthase
Staphylococcus saprophyticus subsp. saprophyticus102446SSP2006putative para-aminobenzoate synthase component
Starkeya novella14993Snov_2281para-aminobenzoate synthase, subunit I
Streptococcus mitis106071SM12261_1217chorismate binding enzyme
Streptomyces cattleya14057SCAT_1462Para-aminobenzoate synthase
SCAT_5490Para-aminobenzoate synthase
Streptomyces ghanaensis15414SSFG_000664-amino-4-deoxychorismate synthase
Streptomyces mobaraensis13819H340_04874para-aminobenzoate synthase
Streptomyces purpureus13925STRPU_02_02020Para-aminobenzoate synthase, amidotransferase co mponent or Para-aminobenzoate synthase, aminase component
Streptomyces venezuelae13096SVEN_0920Para-aminobenzoate synthase, amidotransferase component or Para-aminobenzoate synthase, aminase component
Streptosporangium roseum3776Sros_3761para-aminobenzoate synthase
Synechococcus elongatusSynpcc7942_1334aminodeoxychorismate synthase, subunit I
Synechocystis sp.slr1979anthranilate synthase component I
Turicella otitidis106139HMPREF9719_01781aminodeoxychorismate synthase, component I
Vibrio alginolyticus15630N646_0962para-aminobenzoate synthase component I
Vibrio ichthyoenteri15847VII00023_07094para-aminobenzoate synthase component I
Vibrio metschnikovii103153VIB_001356para-aminobenzoate synthase aminase component
Vibrio orientalis15638VIOR3934_04944para-aminobenzoate synthase component I
Vibrio tubiashii15644VITU9109_22341para-aminobenzoate synthase component I
Vibrio vulnificus15645B736_12235aminodeoxychorismate synthase subunit I
Xenococcus sp.Xen7305DRAFT_00045680aminodeoxychorismate synthase, component I
Yersinia bercovieri105717yberc0001_20110Para-aminobenzoate synthase component 1
Yersinia rohdei105715yrohd0001_28940Para-aminobenzoate synthase component 1
Zymomonas mobilis subsp. pomaceae13757Zymop_1132para-aminobenzoate synthase, subunit I