BLAST table : Urd_00040

DB	UniProtKB

	accession	Evalue	Score	Ident.	link	product	gene	organism
1	Q9RPA1_STRFR (Q9RPA1)	0.0	762	100%	UniProt GenBank	Glycosyl transferase	urdGT1b	Streptomyces fradiae Streptomyces roseoflavus
2	Q9RP99_STRFR (Q9RP99)	0.0	672	92%	UniProt GenBank	Glycosyl transferase	urdGT1c	Streptomyces fradiae Streptomyces roseoflavus
3	D7BZS3_STRBB (D7BZS3)	1e-129	467	62%	UniProt GenBank	Glycosyl transferase, NDP-D-desosamine: 3-L-mycarosyl erythronolide B	SBI_06858	Streptomyces bingchenggensis (strain BCW-1)
4	Q2HR28_9ACTO (Q2HR28)	1e-120	437	59%	UniProt GenBank	Putative O-glycosyltransferase	schS9	Streptomyces sp. SCC 2136
5	Q9ZGB8_STRCY (Q9ZGB8)	1e-114	417	56%	UniProt GenBank	Glycosyl transferase homolog	lanGT1	Streptomyces cyanogenus
6	A4GV88_9ACTO (A4GV88)	1e-113	414	55%	UniProt GenBank	Glycosyltransferase	holL	Streptomyces sp. Tu1156
7	C4NYL1_9ACTO (C4NYL1)	1e-111	407	59%	UniProt GenBank	SaqGT4	saqGT4	Micromonospora sp. Tu 6368
8	C4NYL0_9ACTO (C4NYL0)	1e-110	403	57%	UniProt GenBank	SaqGT3	saqGT3	Micromonospora sp. Tu 6368
9	Q6QR18_STRGL (Q6QR18)	1e-101	373	55%	UniProt GenBank	Glycosyl transferase		Streptomyces globisporus
10	D7BZS5_STRBB (D7BZS5)	1e-100	371	53%	UniProt GenBank	IroB	SBI_06860	Streptomyces bingchenggensis (strain BCW-1)
11	A4GV86_9ACTO (A4GV86)	1e-99	368	52%	UniProt GenBank	Glycosyltransferase	holA	Streptomyces sp. FU107
12	Q9ZGB4_STRCY (Q9ZGB4)	2e-92	344	52%	UniProt GenBank	Glycosyl transferase homolog	lanGT3	Streptomyces cyanogenus
13	E5RLN7_9ACTO (E5RLN7)	3e-80	303	45%	UniProt GenBank	Putative glycosyltransferase	pnxGT2	Streptomyces sp. TA-0256
14	Q4JHR2_9PSEU (Q4JHR2)	1e-59	235	38%	UniProt GenBank	BusG	busG	Saccharopolyspora pogona
15	Q9ALM8_9PSEU (Q9ALM8)	2e-58	231	36%	UniProt GenBank	Probable NDP-rhamnosyltransferase	spnG	Saccharopolyspora spinosa
16	D7BZR2_STRBB (D7BZR2)	5e-55	219	38%	UniProt GenBank	Glycosyl transferase, NDP-D-desosamine: 3-L-mycarosyl erythronolide B	SBI_06847	Streptomyces bingchenggensis (strain BCW-1)
17	D8I4K0_AMYMU (D8I4K0)	2e-50	204	37%	UniProt GenBank	Putative glycosyl transferase	AMED_5414	Amycolatopsis mediterranei (strain U-32)
18	C0JWA0_9ACTO (C0JWA0)	2e-50	204	37%	UniProt GenBank	PokGT2	pokGT2	Streptomyces diastatochromogenes
19	D9SZA9_MICAI (D9SZA9)	7e-50	202	41%	UniProt GenBank	Putative uncharacterized protein	Micau_3719	Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
20	E8S036_MICSL (E8S036)	9e-49	199	40%	UniProt GenBank	Putative uncharacterized protein	ML5_4680	Micromonospora sp. (strain L5)
21	D8I4K4_AMYMU (D8I4K4)	2e-48	197	35%	UniProt GenBank	Putative glycosyl transferase	AMED_5418	Amycolatopsis mediterranei (strain U-32)
22	Q70J70_STRGR (Q70J70)	5e-48	196	37%	UniProt GenBank	Glycosyltransferase	cmmGIII	Streptomyces griseus subsp. griseus
23	Q4R0L9_STRCX (Q4R0L9)	2e-47	194	37%	UniProt GenBank	ChaGT1 protein	chaGT1	Streptomyces chartreusis
24	Q70J80_STRGR (Q70J80)	5e-47	193	36%	UniProt GenBank	Glycosyltransferase	cmmGI	Streptomyces griseus subsp. griseus
25	Q194P9_STRAA (Q194P9)	2e-46	191	36%	UniProt GenBank	Glycosyltransferase	mtmGIII	Streptomyces argillaceus
26	Q0R4P9_STRAT (Q0R4P9)	3e-46	191	36%	UniProt GenBank	ChlC7		Streptomyces antibioticus
27	Q70J67_STRGR (Q70J67)	4e-46	190	39%	UniProt GenBank	Glycosyltransferase	cmmGII	Streptomyces griseus subsp. griseus
28	O87831_STRAT (O87831)	1e-45	188	34%	UniProt GenBank	Glycosyltransferase	oleG2	Streptomyces antibioticus
29	B5L6L8_MICCH (B5L6L8)	8e-45	186	32%	UniProt GenBank	Glycosyltransferase		Micromonospora chalcea
30	D4QF41_9ACTO (D4QF41)	2e-44	184	35%	UniProt GenBank	Rhamnosyltransferase	lipB1	Streptomyces sp. SANK 60405
31	D8I4I4_AMYMU (D8I4I4)	5e-44	183	35%	UniProt GenBank	Putative glycosyl transferase	AMED_5398	Amycolatopsis mediterranei (strain U-32)
32	Q70J68_STRGR (Q70J68)	7e-44	182	34%	UniProt GenBank	Glycosyltransferase	cmmGIV	Streptomyces griseus subsp. griseus
33	Q5SFB5_STRBI (Q5SFB5)	1e-43	182	35%	UniProt GenBank	Putative chalcose glycosyltransferase	chmCIII	Streptomyces bikiniensis
34	Q83WE1_MICGR (Q83WE1)	1e-43	182	34%	UniProt GenBank	Glycosyltransferase	mycB	Micromonospora griseorubida
35	Q2P9Y9_9ACTO (Q2P9Y9)	1e-43	181	35%	UniProt GenBank	Glycosyl transferase	stfG	Streptomyces steffisburgensis
36	D9VBX2_9ACTO (D9VBX2)	2e-43	181	38%	UniProt GenBank	Putative uncharacterized protein	SSMG_03360	Streptomyces sp. AA4
37	Q76KZ6_STRHA (Q76KZ6)	3e-43	181	33%	UniProt GenBank	Glycosyltransferase	vinC	Streptomyces halstedii
38	Q331Q0_9ACTO (Q331Q0)	8e-43	179	34%	UniProt GenBank	Chalcosyltransferase	gerTII	Streptomyces sp. KCTC 0041BP
39	A1C188_9ACTO (A1C188)	1e-42	179	35%	UniProt GenBank	L-rhamnosyltransferase		Streptomyces echinatus
40	B4VEK6_9ACTO (B4VEK6)	1e-42	179	34%	UniProt GenBank	Chalcosyltransferase	SSAG_06216	Streptomyces sp. Mg1
41	A8WDM7_9ACTO (A8WDM7)	2e-42	178	35%	UniProt GenBank	Glycosyltransferase		Streptomyces eurythermus
42	Q194Q0_STRAA (Q194Q0)	4e-42	177	34%	UniProt GenBank	Glycosyltransferase	mtmGIV	Streptomyces argillaceus
43	B3TMP5_9ACTO (B3TMP5)	5e-42	176	35%	UniProt GenBank	Glycosyltransferase	KijC1	Actinomadura kijaniata
44	A4GV85_9ACTO (A4GV85)	6e-42	176	37%	UniProt GenBank	Glycosyltransferase	holC	Streptomyces rufochromogenes
45	Q0R4N0_STRAT (Q0R4N0)	7e-42	176	37%	UniProt GenBank	ChlC6		Streptomyces antibioticus
46	Q54824_STRPE (Q54824)	8e-42	176	34%	UniProt GenBank	Glycosyl transferase	dnrS	Streptomyces peucetius
47	Q9RN63_STRNO (Q9RN63)	1e-41	175	35%	UniProt GenBank	Putative glycosyl transferase	snogE	Streptomyces nogalater
48	D2AY79_STRRD (D2AY79)	3e-41	174	38%	UniProt GenBank	IroB	Sros_4185	Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
49	B3TMN6_9ACTO (B3TMN6)	4e-41	174	33%	UniProt GenBank	Glycosyltransferase	KijA4	Actinomadura kijaniata
50	B3TMP7_9ACTO (B3TMP7)	4e-41	173	32%	UniProt GenBank	Glycosyltransferase	KijC3	Actinomadura kijaniata
51	E3IZG9_FRASU (E3IZG9)	5e-41	173	36%	UniProt GenBank	Putative uncharacterized protein	FraEuI1c_4748	Frankia sp. (strain EuI1c)
52	Q9ZGH7_9ACTO (Q9ZGH7)	6e-41	173	34%	UniProt GenBank	Glycosyl transferase	desVII	Streptomyces venezuelae
53	D1A6T1_THECD (D1A6T1)	1e-40	172	37%	UniProt GenBank	Putative uncharacterized protein	Tcur_2790	Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
54	Q8GHC2_9ACTO (Q8GHC2)	2e-40	171	35%	UniProt GenBank	Glycosyltransferase	cloM	Streptomyces roseochromogenes subsp. oscitans
55	B5L6L9_MICCH (B5L6L9)	3e-40	171	34%	UniProt GenBank	Glycosyltransferase		Micromonospora chalcea
56	D8I4J9_AMYMU (D8I4J9)	3e-40	171	37%	UniProt GenBank	Putative glycosyl transferase	AMED_5413	Amycolatopsis mediterranei (strain U-32)
57	D6AXN2_9ACTO (D6AXN2)	3e-40	170	34%	UniProt GenBank	RdmH	SSHG_05324	Streptomyces albus J1074
58	A8Y8I1_STRAM (A8Y8I1)	5e-40	170	32%	UniProt GenBank	Probable glycosyltransferase	srm17	Streptomyces ambofaciens
59	B5G8A2_9ACTO (B5G8A2)	8e-40	169	37%	UniProt GenBank	Glycosyltransferase family 28 domain-containing protein	SSBG_00510	Streptomyces sp. SPB74
60	Q935Z8_9ACTO (Q935Z8)	9e-40	169	35%	UniProt GenBank	RdmH	rdmH	Streptomyces purpurascens
61	E8RWS4_MICSL (E8RWS4)	1e-39	168	34%	UniProt GenBank	Putative uncharacterized protein	ML5_4413	Micromonospora sp. (strain L5)
62	D9T2A5_MICAI (D9T2A5)	1e-39	168	34%	UniProt GenBank	Putative uncharacterized protein	Micau_4008	Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
63	Q9L4U6_9ACTO (Q9L4U6)	3e-39	167	36%	UniProt GenBank	Putative glycosyl transferase	aknS	Streptomyces galilaeus
64	D7B009_NOCDD (D7B009)	3e-39	167	33%	UniProt GenBank	Putative uncharacterized protein	Ndas_4711	Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488) Actinomadura dassonvillei
65	Q194P5_STRAA (Q194P5)	7e-39	166	33%	UniProt GenBank	Glycosyltransferase	mtmGI	Streptomyces argillaceus
66	Q9L9F5_STRSH (Q9L9F5)	9e-39	166	35%	UniProt GenBank	NovM	novM	Streptomyces spheroides Streptomyces caeruleus
67	B5G890_9ACTO (B5G890)	9e-39	166	32%	UniProt GenBank	Glycosyltransferase family 28 domain-containing protein	SSBG_00498	Streptomyces sp. SPB74
68	Q4JHQ3_9PSEU (Q4JHQ3)	1e-38	165	34%	UniProt GenBank	BusP	busP	Saccharopolyspora pogona
69	O87830_STRAT (O87830)	2e-38	164	33%	UniProt GenBank	Glycosyltransferase	oleG1	Streptomyces antibioticus
70	Q52V43_9ACTO (Q52V43)	2e-38	164	35%	UniProt GenBank	Glycosyltransferase		Streptomyces aizunensis
71	D8I4J6_AMYMU (D8I4J6)	3e-38	164	35%	UniProt GenBank	Putative glycosyl transferase	AMED_5410	Amycolatopsis mediterranei (strain U-32)
72	B5L6J8_MICCH (B5L6J8)	4e-38	163	35%	UniProt GenBank	Glycosyltransferase		Micromonospora chalcea
73	C4NYK7_9ACTO (C4NYK7)	4e-38	163	34%	UniProt GenBank	SaqGT1	saqGT1	Micromonospora sp. Tu 6368
74	B0LJ53_9ACTO (B0LJ53)	6e-38	162	33%	UniProt GenBank	Lcz36	lcz36	Streptomyces sanglieri
75	Q8KRX7_9ACTO (Q8KRX7)	6e-38	162	32%	UniProt GenBank	NbmD	nbmD	Streptomyces narbonensis
76	Q5Y9G8_9ACTO (Q5Y9G8)	2e-37	161	35%	UniProt GenBank	L-desosaminyltransferase	eryCIII	Aeromicrobium erythreum
77	P95834_STRPE (P95834)	3e-37	160	33%	UniProt GenBank	Putative baumycin biosynthesis protein	dnrH	Streptomyces peucetius
78	E1ARK6_STRAU (E1ARK6)	3e-37	160	33%	UniProt GenBank	Putative glycosyltransferase	sa46	Streptomyces aureofaciens
79	Q194P6_STRAA (Q194P6)	3e-37	160	36%	UniProt GenBank	Glycosyltransferase	mtmGII	Streptomyces argillaceus
80	Q9RN61_STRNO (Q9RN61)	5e-37	160	35%	UniProt GenBank	Putative glycosyl transferase	snogD	Streptomyces nogalater
81	A0ACI7_STRAM (A0ACI7)	5e-37	160	32%	UniProt GenBank	Putative glycosyltransferase	SAMR0481	Streptomyces ambofaciens ATCC 23877
82	D7AZB3_NOCDD (D7AZB3)	9e-37	159	34%	UniProt GenBank	Putative uncharacterized protein	Ndas_4707	Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488) Actinomadura dassonvillei
83	D7RFK8_AMYOR (D7RFK8)	1e-36	158	35%	UniProt GenBank	Putative glycosyltransferase	bexG1	Amycolatopsis orientalis subsp. vinearia
84	A4GV89_9ACTO (A4GV89)	1e-36	158	34%	UniProt GenBank	Glycosyltransferase	holN	Streptomyces sp. FU107
85	Q9L555_9ACTO (Q9L555)	2e-36	157	31%	UniProt GenBank	AknK	aknK	Streptomyces galilaeus
86	D7B025_NOCDD (D7B025)	3e-36	157	33%	UniProt GenBank	Putative uncharacterized protein	Ndas_4727	Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488) Actinomadura dassonvillei
87	Q8VWB7_9ACTO (Q8VWB7)	3e-36	157	31%	UniProt GenBank	AclK	aclK	Streptomyces galilaeus
88	Q2HR27_9ACTO (Q2HR27)	4e-36	157	34%	UniProt GenBank	Putative O-glycosyltransferase	schS10	Streptomyces sp. SCC 2136
89	Q9F8U7_9ACTO (Q9F8U7)	4e-36	157	35%	UniProt GenBank	Glycosyl transferase	couM	Streptomyces rishiriensis
90	Q0H2X6_9ACTO (Q0H2X6)	4e-36	157	33%	UniProt GenBank	Putative O-glycosyltransferase	atG1	Actinomadura melliaura
91	Q9ALN7_9PSEU (Q9ALN7)	4e-36	157	33%	UniProt GenBank	Probable NDP-forosamyltransferase	spnP	Saccharopolyspora spinosa
92	Q9F839_9ACTO (Q9F839)	5e-36	156	33%	UniProt GenBank	TDP-megosamine glycosyltransferase	megDI	Micromonospora megalomicea subsp. nigra
93	Q83X73_STRRO (Q83X73)	5e-36	156	32%	UniProt GenBank	Glycosyltransferase LkmI	lkmI	Streptomyces rochei Streptomyces parvullus
94	E5L4T5_9ACTO (E5L4T5)	6e-36	156	30%	UniProt GenBank	Glycosyltransferase		Streptomyces sp. SCSIO 01934
95	D5UX47_TSUPD (D5UX47)	7e-36	156	33%	UniProt GenBank	Putative uncharacterized protein	Tpau_3487	Tsukamurella paurometabola (strain ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040) Corynebacterium paurometabolum
96	D7AZA5_NOCDD (D7AZA5)	1e-35	155	33%	UniProt GenBank	Putative uncharacterized protein	Ndas_4699	Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488) Actinomadura dassonvillei
97	B3TMR7_9ACTO (B3TMR7)	1e-35	155	34%	UniProt GenBank	Glycosyltransferase	KijD9	Actinomadura kijaniata
98	Q6T1C7_STRGL (Q6T1C7)	1e-35	155	33%	UniProt GenBank	Glycosyltransferase LndGT4		Streptomyces globisporus
99	C0JWA3_9ACTO (C0JWA3)	1e-35	155	34%	UniProt GenBank	PokGT1	pokGT1	Streptomyces diastatochromogenes
100	D6MSX4_9ACTO (D6MSX4)	1e-35	155	31%	UniProt GenBank	SsfS6	ssfS6	Streptomyces sp. SF2575

accession

alignment

Evalue

Score

Ident.

link

information

pubmed

Q9RPA1_STRFR
(Q9RPA1)

0.0

762

100%

Product: Glycosyl transferase
Gene: urdGT1b
Organism: Streptomyces fradiae
Streptomyces roseoflavus

1uniprot[Pubmed] 10658661 [Medline] 20121748
Two new tailoring enzymes, a glycosyltransferase and an oxygenase, involved in biosynthesis of the angucycline antibiotic urdamycin A in Streptomyces fradiae Tu2717.(Microbiology) [2000]

Q9RP99_STRFR
(Q9RP99)

0.0

672

92%

Product: Glycosyl transferase
Gene: urdGT1c
Organism: Streptomyces fradiae
Streptomyces roseoflavus

D7BZS3_STRBB
(D7BZS3)

1e-129

467

62%

Product: Glycosyl transferase, NDP-D-desosamine: 3-L-mycarosyl erythronolide B
Gene: SBI_06858
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

Q2HR28_9ACTO
(Q2HR28)

1e-120

437

59%

Product: Putative O-glycosyltransferase
Gene: schS9
Organism: Streptomyces sp. SCC 2136

1uniprot
Angucyclines Sch 47554 and Sch 47555 from Streptomyces sp. SCC-2136: Cloning, Sequencing, and Characterization.(Mol. Cells) [2006]

2uniprot
Molecular cloning and characterization of biosynthetic genes cluster of Sch 47554 from Streptomyces sp. SCC 2136. [2004]

Q9ZGB8_STRCY
(Q9ZGB8)

1e-114

417

56%

Product: Glycosyl transferase homolog
Gene: lanGT1
Organism: Streptomyces cyanogenus

1uniprot[Pubmed] 9933932 [Medline] 99132695
Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin biosynthesis.(FEMS Microbiol. Lett.) [1999]

A4GV88_9ACTO
(A4GV88)

1e-113

414

55%

Product: Glycosyltransferase
Gene: holL
Organism: Streptomyces sp. Tu1156

1uniprot[Pubmed] 17497146
A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]

C4NYL1_9ACTO
(C4NYL1)

1e-111

407

59%

Product: SaqGT4
Gene: saqGT4
Organism: Micromonospora sp. Tu 6368

[pubmed all]
1uniprot[Pubmed] 17497146 A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]
2uniprot[Pubmed] 19384899 Cloning and sequencing of the biosynthetic gene cluster for saquayamycin z and galtamycin B and the elucidation of the assembly of their saccharide chains.(Chembiochem) [2009]

C4NYL0_9ACTO
(C4NYL0)

1e-110

403

57%

Product: SaqGT3
Gene: saqGT3
Organism: Micromonospora sp. Tu 6368

[pubmed all]
1uniprot[Pubmed] 17497146 A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]
2uniprot[Pubmed] 19384899 Cloning and sequencing of the biosynthetic gene cluster for saquayamycin z and galtamycin B and the elucidation of the assembly of their saccharide chains.(Chembiochem) [2009]

Q6QR18_STRGL
(Q6QR18)

1e-101

373

55%

Product: Glycosyl transferase
Gene
Organism: Streptomyces globisporus

1uniprot[Pubmed] 15123249
Generation of new landomycins by combinatorial biosynthetic manipulation of the LndGT4 gene of the landomycin E cluster in S. globisporus.(Chem. Biol.) [2004]

D7BZS5_STRBB
(D7BZS5)

1e-100

371

53%

Product: IroB
Gene: SBI_06860
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

A4GV86_9ACTO
(A4GV86)

1e-99

368

52%

Product: Glycosyltransferase
Gene: holA
Organism: Streptomyces sp. FU107

1uniprot[Pubmed] 17497146
A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]

Q9ZGB4_STRCY
(Q9ZGB4)

2e-92

344

52%

Product: Glycosyl transferase homolog
Gene: lanGT3
Organism: Streptomyces cyanogenus

Q4JHR2_9PSEU
(Q4JHR2)

1e-59

235

38%

Product: BusG
Gene: busG
Organism: Saccharopolyspora pogona

1uniprot[Pubmed] 16179985
Butenyl-spinosyns, a natural example of genetic engineering of antibiotic biosynthetic genes.(J. Ind. Microbiol. Biotechnol.) [2006]

Q9ALM8_9PSEU
(Q9ALM8)

2e-58

231

36%

Product: Probable NDP-rhamnosyltransferase
Gene: spnG
Organism: Saccharopolyspora spinosa

1uniprot[Pubmed] 11358695 [Medline] 21257765
Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa.(Chem. Biol.) [2001]

D7BZR2_STRBB
(D7BZR2)

5e-55

219

38%

Product: Glycosyl transferase, NDP-D-desosamine: 3-L-mycarosyl erythronolide B
Gene: SBI_06847
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

D8I4K0_AMYMU
(D8I4K0)

2e-50

204

37%

Product: Putative glycosyl transferase
Gene: AMED_5414
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

C0JWA0_9ACTO
(C0JWA0)

2e-50

204

37%

Product: PokGT2
Gene: pokGT2
Organism: Streptomyces diastatochromogenes

1uniprot[Pubmed] 19266534
Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009]

D8I4K4_AMYMU
(D8I4K4)

2e-48

197

35%

Product: Putative glycosyl transferase
Gene: AMED_5418
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

Q4R0L9_STRCX
(Q4R0L9)

2e-47

194

37%

Product: ChaGT1 protein
Gene: chaGT1
Organism: Streptomyces chartreusis

1uniprot[Pubmed] 15911378
Biosynthesis of the antitumor agent chartreusin involves the oxidative rearrangement of an anthracyclic polyketide.(Chem. Biol.) [2005]

Q194P9_STRAA
(Q194P9)

2e-46

191

36%

Product: Glycosyltransferase
Gene: mtmGIII
Organism: Streptomyces argillaceus

[pubmed all]
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]

Q0R4P9_STRAT
(Q0R4P9)

3e-46

191

36%

Product: ChlC7
Gene
Organism: Streptomyces antibioticus

1uniprot[Pubmed] 16793515
Genetic characterization of the chlorothricin gene cluster as a model for spirotetronate antibiotic biosynthesis.(Chem. Biol.) [2006]

O87831_STRAT
(O87831)

1e-45

188

34%

Product: Glycosyltransferase
Gene: oleG2
Organism: Streptomyces antibioticus

1uniprot[Pubmed] 9749673 [Medline] 98420102
Analysis of a Streptomyces antibioticus chromosomal region involved in oleandomycin biosynthesis, which encodes two glycosyltransferases responsible for glycosylation of the macrolactone ring.(Mol. Gen. Genet.) [1998]

B5L6L8_MICCH
(B5L6L8)

8e-45

186

32%

Product: Glycosyltransferase
Gene
Organism: Micromonospora chalcea

1uniprot[Pubmed] 18586939
Cloning and characterization of the tetrocarcin A gene cluster from Micromonospora chalcea NRRL 11289 reveals a highly conserved strategy for tetronate biosynthesis in spirotetronate antibiotics.(J. Bacteriol.) [2008]

D4QF41_9ACTO
(D4QF41)

2e-44

184

35%

Product: Rhamnosyltransferase
Gene: lipB1
Organism: Streptomyces sp. SANK 60405

1uniprot[Pubmed] 20043306
The biosynthesis of liposidomycin-like A-90289 antibiotics featuring a new type of sulfotransferase.(Chembiochem) [2010]

D8I4I4_AMYMU
(D8I4I4)

5e-44

183

35%

Product: Putative glycosyl transferase
Gene: AMED_5398
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

Q5SFB5_STRBI
(Q5SFB5)

1e-43

182

35%

Product: Putative chalcose glycosyltransferase
Gene: chmCIII
Organism: Streptomyces bikiniensis

1uniprot[Pubmed] 15561847
Chalcomycin biosynthesis gene cluster from Streptomyces bikiniensis: novel features of an unusual ketolide produced through expression of the chm polyketide synthase in Streptomyces fradiae.(Antimicrob. Agents Chemother.) [2004]

Q83WE1_MICGR
(Q83WE1)

1e-43

182

34%

Product: Glycosyltransferase
Gene: mycB
Organism: Micromonospora griseorubida

1uniprot[Pubmed] 12583909 [Medline] 22472038
Organization of the biosynthetic gene cluster for the polyketide macrolide mycinamicin in Micromonospora griseorubida.(FEMS Microbiol. Lett.) [2003]

Q2P9Y9_9ACTO
(Q2P9Y9)

1e-43

181

35%

Product: Glycosyl transferase
Gene: stfG
Organism: Streptomyces steffisburgensis

1uniprot[Pubmed] 16751529
Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin.(Appl. Environ. Microbiol.) [2006]

Q76KZ6_STRHA
(Q76KZ6)

3e-43

181

33%

Product: Glycosyltransferase
Gene: vinC
Organism: Streptomyces halstedii

1uniprot[Pubmed] 15112997
Cloning, sequencing, and functional analysis of the biosynthetic gene cluster of macrolactam antibiotic vicenistatin in Streptomyces halstedii.(Chem. Biol.) [2004]

Q331Q0_9ACTO
(Q331Q0)

8e-43

179

34%

Product: Chalcosyltransferase
Gene: gerTII
Organism: Streptomyces sp. KCTC 0041BP

1uniprot[Pubmed] 17053005
Biosynthesis of dTDP-6-deoxy-beta-D-allose, biochemical characterization of dTDP-4-keto-6-deoxyglucose reductase (GerKI) from Streptomyces sp. KCTC 0041BP.(Glycobiology) [2007]

2uniprot
Cloning and characterization of a gene cluster for the production of the polyketide macrolide antibiotic dihydrochalcomycin in Streptomyces sp. KCTC 0041BP.(J. Microbiol. Biotechnol.) [2006]

Q194Q0_STRAA
(Q194Q0)

4e-42

177

34%

Product: Glycosyltransferase
Gene: mtmGIV
Organism: Streptomyces argillaceus

[pubmed all]
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]

B3TMP5_9ACTO
(B3TMP5)

5e-42

176

35%

Product: Glycosyltransferase
Gene: KijC1
Organism: Actinomadura kijaniata

1uniprot[Pubmed] 17985890
Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007]

A4GV85_9ACTO
(A4GV85)

6e-42

176

37%

Product: Glycosyltransferase
Gene: holC
Organism: Streptomyces rufochromogenes

1uniprot[Pubmed] 17497146
A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]

Q0R4N0_STRAT
(Q0R4N0)

7e-42

176

37%

Product: ChlC6
Gene
Organism: Streptomyces antibioticus

1uniprot[Pubmed] 16793515
Genetic characterization of the chlorothricin gene cluster as a model for spirotetronate antibiotic biosynthesis.(Chem. Biol.) [2006]

Q54824_STRPE
(Q54824)

8e-42

176

34%

Product: Glycosyl transferase
Gene: dnrS
Organism: Streptomyces peucetius

1uniprot[Pubmed] 7592454 [Medline] 96062261
Cloning and characterization of the Streptomyces peucetius dnrQS genes encoding a daunosamine biosynthesis enzyme and a glycosyl transferase involved in daunorubicin biosynthesis.(J. Bacteriol.) [1995]

Q9RN63_STRNO
(Q9RN63)

1e-41

175

35%

Product: Putative glycosyl transferase
Gene: snogE
Organism: Streptomyces nogalater

[pubmed all]
1uniprot[Pubmed] 9349712 [Medline] 98007868 Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.(Mol. Gen. Genet.) [1997]
2uniprot[Pubmed] 10639368 [Medline] 20106987 Identification of a cyclase gene dictating the C-9 stereochemistry of anthracyclines from Streptomyces nogalater.(Antimicrob. Agents Chemother.) [2000]

D2AY79_STRRD
(D2AY79)

3e-41

174

38%

Product: IroB
Gene: Sros_4185
Organism: Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)

1uniprot
Complete genome sequence of Streptosporangium roseum type strain (NI 9100T).(Stand. Genomic Sci.) [2010]

B3TMN6_9ACTO
(B3TMN6)

4e-41

174

33%

Product: Glycosyltransferase
Gene: KijA4
Organism: Actinomadura kijaniata

1uniprot[Pubmed] 17985890
Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007]

B3TMP7_9ACTO
(B3TMP7)

4e-41

173

32%

Product: Glycosyltransferase
Gene: KijC3
Organism: Actinomadura kijaniata

1uniprot[Pubmed] 17985890
Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007]

Q9ZGH7_9ACTO
(Q9ZGH7)

6e-41

173

34%

Product: Glycosyl transferase
Gene: desVII
Organism: Streptomyces venezuelae

1uniprot[Pubmed] 9770448 [Medline] 98445333
A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity.(Proc. Natl. Acad. Sci. U.S.A.) [1998]

D1A6T1_THECD
(D1A6T1)

1e-40

172

37%

Product: Putative uncharacterized protein
Gene: Tcur_2790
Organism: Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)

1uniprot
Complete genome sequence of Thermomonospora curvata type strain (B9).(Stand. Genomic Sci.) [2011]

Q8GHC2_9ACTO
(Q8GHC2)

2e-40

171

35%

Product: Glycosyltransferase
Gene: cloM
Organism: Streptomyces roseochromogenes subsp. oscitans

1uniprot[Pubmed] 12480894 [Medline] 22368916
Molecular cloning and sequence analysis of the clorobiocin biosynthetic gene cluster: new insights into the biosynthesis of aminocoumarin antibiotics.(Microbiology) [2002]

B5L6L9_MICCH
(B5L6L9)

3e-40

171

34%

Product: Glycosyltransferase
Gene
Organism: Micromonospora chalcea

D8I4J9_AMYMU
(D8I4J9)

3e-40

171

37%

Product: Putative glycosyl transferase
Gene: AMED_5413
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

A8Y8I1_STRAM
(A8Y8I1)

5e-40

170

32%

Product: Probable glycosyltransferase
Gene: srm17
Organism: Streptomyces ambofaciens

1uniprot
Organization of the biosynthetic gene cluster for the macrolide antibiotic spiramycin in Streptomyces ambofaciens.(Microbiology (Mosc.)) [2007]

Q9L4U6_9ACTO
(Q9L4U6)

3e-39

167

36%

Product: Putative glycosyl transferase
Gene: aknS
Organism: Streptomyces galilaeus

1uniprot[Pubmed] 11016846 [Medline] 20469061
A gene cluster from Streptomyces galilaeus involved in glycosylation of aclarubicin.(Mol. Gen. Genet.) [2000]

D7B009_NOCDD
(D7B009)

3e-39

167

33%

Product: Putative uncharacterized protein
Gene: Ndas_4711
Organism: Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei

1uniprot
Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010]

Q194P5_STRAA
(Q194P5)

7e-39

166

33%

Product: Glycosyltransferase
Gene: mtmGI
Organism: Streptomyces argillaceus

[pubmed all]
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]

Q9L9F5_STRSH
(Q9L9F5)

9e-39

166

35%

Product: NovM
Gene: novM
Organism: Streptomyces spheroides
Streptomyces caeruleus

1uniprot[Pubmed] 10770754 [Medline] 20233587
Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891.(Antimicrob. Agents Chemother.) [2000]

Q4JHQ3_9PSEU
(Q4JHQ3)

1e-38

165

34%

Product: BusP
Gene: busP
Organism: Saccharopolyspora pogona

1uniprot[Pubmed] 16179985
Butenyl-spinosyns, a natural example of genetic engineering of antibiotic biosynthetic genes.(J. Ind. Microbiol. Biotechnol.) [2006]

O87830_STRAT
(O87830)

2e-38

164

33%

Product: Glycosyltransferase
Gene: oleG1
Organism: Streptomyces antibioticus

Q52V43_9ACTO
(Q52V43)

2e-38

164

35%

Product: Glycosyltransferase
Gene
Organism: Streptomyces aizunensis

1uniprot[Pubmed] 15844935
Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example.(J. Nat. Prod.) [2005]

D8I4J6_AMYMU
(D8I4J6)

3e-38

164

35%

Product: Putative glycosyl transferase
Gene: AMED_5410
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

B5L6J8_MICCH
(B5L6J8)

4e-38

163

35%

Product: Glycosyltransferase
Gene
Organism: Micromonospora chalcea

C4NYK7_9ACTO
(C4NYK7)

4e-38

163

34%

Product: SaqGT1
Gene: saqGT1
Organism: Micromonospora sp. Tu 6368

[pubmed all]
1uniprot[Pubmed] 17497146 A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]
2uniprot[Pubmed] 19384899 Cloning and sequencing of the biosynthetic gene cluster for saquayamycin z and galtamycin B and the elucidation of the assembly of their saccharide chains.(Chembiochem) [2009]

B0LJ53_9ACTO
(B0LJ53)

6e-38

162

33%

Product: Lcz36
Gene: lcz36
Organism: Streptomyces sanglieri

1uniprot[Pubmed] 18070976
Biosynthetic investigations of lactonamycin and lactonamycin z: cloning of the biosynthetic gene clusters and discovery of an unusual starter unit.(Antimicrob. Agents Chemother.) [2008]

Q5Y9G8_9ACTO
(Q5Y9G8)

2e-37

161

35%

Product: L-desosaminyltransferase
Gene: eryCIII
Organism: Aeromicrobium erythreum

1uniprot[Pubmed] 15257441
The erythromycin biosynthetic gene cluster of Aeromicrobium erythreum.(J. Ind. Microbiol. Biotechnol.) [2004]

P95834_STRPE
(P95834)

3e-37

160

33%

Product: Putative baumycin biosynthesis protein
Gene: dnrH
Organism: Streptomyces peucetius

[pubmed all]
1uniprot[Pubmed] 8955419 [Medline] 97113559 Enhanced antibiotic production by manipulation of the Streptomyces peucetius dnrH and dnmT genes involved in doxorubicin (adriamycin) biosynthesis.(J. Bacteriol.) [1996]
2uniprot[Pubmed] 9864344 [Medline] 99084971 Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene.(J. Bacteriol.) [1999]

E1ARK6_STRAU
(E1ARK6)

3e-37

160

33%

Product: Putative glycosyltransferase
Gene: sa46
Organism: Streptomyces aureofaciens

1uniprot[Pubmed] 21393365
The role of two SARP family transcriptional regulators in regulation of the auricin gene cluster in Streptomyces aureofaciens CCM 3239.(Microbiology) [2011]

Q194P6_STRAA
(Q194P6)

3e-37

160

36%

Product: Glycosyltransferase
Gene: mtmGII
Organism: Streptomyces argillaceus

[pubmed all]
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]

Q9RN61_STRNO
(Q9RN61)

5e-37

160

35%

Product: Putative glycosyl transferase
Gene: snogD
Organism: Streptomyces nogalater

[pubmed all]
1uniprot[Pubmed] 9349712 [Medline] 98007868 Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.(Mol. Gen. Genet.) [1997]
2uniprot[Pubmed] 10639368 [Medline] 20106987 Identification of a cyclase gene dictating the C-9 stereochemistry of anthracyclines from Streptomyces nogalater.(Antimicrob. Agents Chemother.) [2000]

A0ACI7_STRAM
(A0ACI7)

5e-37

160

32%

Product: Putative glycosyltransferase
Gene: SAMR0481
Organism: Streptomyces ambofaciens ATCC 23877

1uniprot[Pubmed] 16956972
Evolution of the terminal regions of the Streptomyces linear chromosome.(Mol. Biol. Evol.) [2006]

2uniprot
Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877.(Microbiology (Mosc.)) [2006]

D7AZB3_NOCDD
(D7AZB3)

9e-37

159

34%

Product: Putative uncharacterized protein
Gene: Ndas_4707
Organism: Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei

1uniprot
Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010]

D7RFK8_AMYOR
(D7RFK8)

1e-36

158

35%

Product: Putative glycosyltransferase
Gene: bexG1
Organism: Amycolatopsis orientalis subsp. vinearia

1uniprot[Pubmed] 20443562
A biosynthetic pathway for BE-7585A, a 2-thiosugar-containing angucycline-type natural product.(J. Am. Chem. Soc.) [2010]

A4GV89_9ACTO
(A4GV89)

1e-36

158

34%

Product: Glycosyltransferase
Gene: holN
Organism: Streptomyces sp. FU107

1uniprot[Pubmed] 17497146
A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]

Q9L555_9ACTO
(Q9L555)

2e-36

157

31%

Product: AknK
Gene: aknK
Organism: Streptomyces galilaeus

1uniprot[Pubmed] 12137949 [Medline] 22133312
Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster.(Gene) [2002]

D7B025_NOCDD
(D7B025)

3e-36

157

33%

Product: Putative uncharacterized protein
Gene: Ndas_4727
Organism: Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei

1uniprot
Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010]

Q8VWB7_9ACTO
(Q8VWB7)

3e-36

157

31%

Product: AclK
Gene: aclK
Organism: Streptomyces galilaeus

1uniprot[Pubmed] 12399480 [Medline] 22286521
Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus.(J. Bacteriol.) [2002]

Q2HR27_9ACTO
(Q2HR27)

4e-36

157

34%

Product: Putative O-glycosyltransferase
Gene: schS10
Organism: Streptomyces sp. SCC 2136

1uniprot
Angucyclines Sch 47554 and Sch 47555 from Streptomyces sp. SCC-2136: Cloning, Sequencing, and Characterization.(Mol. Cells) [2006]

2uniprot
Molecular cloning and characterization of biosynthetic genes cluster of Sch 47554 from Streptomyces sp. SCC 2136. [2004]

Q9F8U7_9ACTO
(Q9F8U7)

4e-36

157

35%

Product: Glycosyl transferase
Gene: couM
Organism: Streptomyces rishiriensis

1uniprot[Pubmed] 11036020 [Medline] 20493109
Identification of the coumermycin A(1) biosynthetic gene cluster of Streptomyces rishiriensis DSM 40489.(Antimicrob. Agents Chemother.) [2000]

Q0H2X6_9ACTO
(Q0H2X6)

4e-36

157

33%

Product: Putative O-glycosyltransferase
Gene: atG1
Organism: Actinomadura melliaura

1uniprot[Pubmed] 16873021
Deciphering indolocarbazole and enediyne aminodideoxypentose biosynthesis through comparative genomics: insights from the AT2433 biosynthetic locus.(Chem. Biol.) [2006]

Q9ALN7_9PSEU
(Q9ALN7)

4e-36

157

33%

Product: Probable NDP-forosamyltransferase
Gene: spnP
Organism: Saccharopolyspora spinosa

1uniprot[Pubmed] 11358695 [Medline] 21257765
Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa.(Chem. Biol.) [2001]

Q9F839_9ACTO
(Q9F839)

5e-36

156

33%

Product: TDP-megosamine glycosyltransferase
Gene: megDI
Organism: Micromonospora megalomicea subsp. nigra

1uniprot[Pubmed] 10972798 [Medline] 20430101
Biosynthesis of the anti-parasitic agent megalomicin: transformation of erythromycin to megalomicin in Saccharopolyspora erythraea.(Mol. Microbiol.) [2000]

Q83X73_STRRO
(Q83X73)

5e-36

156

32%

Product: Glycosyltransferase LkmI
Gene: lkmI
Organism: Streptomyces rochei
Streptomyces parvullus

[pubmed all]
1uniprot[Pubmed] 12791134 [Medline] 22676866 The large linear plasmid pSLA2-L of Streptomyces rochei has an unusually condensed gene organization for secondary metabolism.(Mol. Microbiol.) [2003]
2uniprot[Pubmed] 10954087 [Medline] 20408175 Cloning and analysis of the replication origin and the telomeres of the large linear plasmid pSLA2-L in Streptomyces rochei.(Mol. Gen. Genet.) [2000]
3uniprot[Pubmed] 10767533 [Medline] 20231737 Identification of two polyketide synthase gene clusters on the linear plasmid pSLA2-L in Streptomyces rochei.(Gene) [2000]
4uniprot[Pubmed] 9836424 [Medline] 99053144 Physical mapping of the linear plasmid pSLA2-L and localization of the eryAI and actI homologs.(Biosci. Biotechnol. Biochem.) [1998]

D7AZA5_NOCDD
(D7AZA5)

1e-35

155

33%

Product: Putative uncharacterized protein
Gene: Ndas_4699
Organism: Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei

1uniprot
Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010]

B3TMR7_9ACTO
(B3TMR7)

1e-35

155

34%

Product: Glycosyltransferase
Gene: KijD9
Organism: Actinomadura kijaniata

1uniprot[Pubmed] 17985890
Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007]

Q6T1C7_STRGL
(Q6T1C7)

1e-35

155

33%

Product: Glycosyltransferase LndGT4
Gene
Organism: Streptomyces globisporus

1uniprot[Pubmed] 15123249
Generation of new landomycins by combinatorial biosynthetic manipulation of the LndGT4 gene of the landomycin E cluster in S. globisporus.(Chem. Biol.) [2004]

C0JWA3_9ACTO
(C0JWA3)

1e-35

155

34%

Product: PokGT1
Gene: pokGT1
Organism: Streptomyces diastatochromogenes

1uniprot[Pubmed] 19266534
Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009]

100

D6MSX4_9ACTO
(D6MSX4)

1e-35

155

31%

Product: SsfS6
Gene: ssfS6
Organism: Streptomyces sp. SF2575

1uniprot[Pubmed] 19908837
Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.(J. Am. Chem. Soc.) [2009]