| accession | DB | alignment | Evalue | Score | Ident. | link | information | pubmed |
1
|
C0JWA9_9ACTO (C0JWA9) |
|
|
0.0 |
974 |
100% |
|
- Product
- PokS3
- Gene
- pokS3
- Organism
- Streptomyces diastatochromogenes
|
1uniprot[Pubmed] 19266534 Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009] |
|
2
|
Q93F99_STRAT (Q93F99) |
|
|
1e-144 |
516 |
55% |
|
- Product
- Sim20
- Gene
- sim20
- Organism
- Streptomyces antibioticus
|
1uniprot[Pubmed] 12115055 [Medline] 22109063 Cloning and analysis of the simocyclinone biosynthetic gene cluster of Streptomyces antibioticus Tu 6040.(Arch. Microbiol.) [2002] |
|
3
|
Q9AMH2_STRAT (Q9AMH2) |
|
|
1e-143 |
512 |
55% |
|
- Product
- Putative dNDP-4-keto-6-deoxy-glucose-2,3-dehydratase SimB3
- Gene
- simB3
- Organism
- Streptomyces antibioticus
|
1uniprot[Pubmed] 11959542 [Medline] 21955989 Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibiotic.(Antimicrob. Agents Chemother.) [2002] |
|
4
|
D6MSX2_9ACTO (D6MSX2) |
|
|
1e-139 |
501 |
54% |
|
- Product
- SsfS3
- Gene
- ssfS3
- Organism
- Streptomyces sp. SF2575
|
1uniprot[Pubmed] 19908837 Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.(J. Am. Chem. Soc.) [2009] |
|
5
|
Q194Q2_STRAA (Q194Q2) |
|
|
1e-137 |
492 |
53% |
|
- Product
- D-olivose, D-oliose and D-mycarose 2,3-dehydratase
- Gene
- mtmV
- Organism
- Streptomyces argillaceus
|
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996] | 2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996] | 3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997] | 4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998] | 5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999] | 6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999] | 7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000] | 8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001] | 9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003] | 10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999] | 11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002] | 12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000] | 13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000] | 14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002] | 15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003] | 16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996] | 17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004] | 18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997] | 19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005] | 20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000] | [pubmed all]
|
6
|
B8Y4F2_STRAU (B8Y4F2) |
|
|
1e-135 |
487 |
57% |
|
- Product
- Putative NDP-hexose 2,3-dehydratase
- Gene
- aur1S
- Organism
- Streptomyces aureofaciens
|
1uniprot[Pubmed] 20490753 Identification and characterization of an indigoidine-like gene for a blue pigment biosynthesis in Streptomyces aureofaciens CCM 3239.(Folia Microbiol. (Praha)) [2010] |
|
7
|
Q76KZ0_STRHA (Q76KZ0) |
|
|
1e-135 |
485 |
53% |
|
- Product
- DTDP-4-keto-6-deoxyglucose 2,3-dehydratase
- Gene
- vinD
- Organism
- Streptomyces halstedii
|
1uniprot[Pubmed] 15112997 Cloning, sequencing, and functional analysis of the biosynthetic gene cluster of macrolactam antibiotic vicenistatin in Streptomyces halstedii.(Chem. Biol.) [2004] |
|
8
|
Q9RR31_STRAT (Q9RR31) |
|
|
1e-134 |
483 |
55% |
|
- Product
- 2,3-dehydratase
- Gene
- oleV
- Organism
- Streptomyces antibioticus
|
1uniprot[Pubmed] 10770761 [Medline] 20233594 Identification and expression of genes involved in biosynthesis of L-oleandrose and its intermediate L-olivose in the oleandomycin producer Streptomyces antibioticus.(Antimicrob. Agents Chemother.) [2000] |
|
9
|
E9L1G4_9ZZZZ (E9L1G4) |
|
(3 hsp) |
1e-134 |
482 |
55% |
|
- Product
- Putative uncharacterized protein
- Gene
- CA37-20
- Organism
- uncultured organism CA37
|
1uniprot[Pubmed] 20945895 Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010] |
|
10
|
Q9L6C6_STRAT (Q9L6C6) |
|
|
1e-133 |
481 |
54% |
|
- Product
- DTDP-4-keto-6-deoxyglucose 2,3-dehydratase
- Gene
-
- Organism
- Streptomyces antibioticus
|
1uniprot Mechanism of the 2-deoxygenation step in the biosynthesis of the deoxyhexose moieties of the antibiotics granaticin and oleandomycin.(J. Am. Chem. Soc.) [1999] |
|
11
|
Q7WT23_9ACTO (Q7WT23) |
|
|
1e-133 |
478 |
54% |
|
- Product
- NDP-deoxyglucose-2,3-dehydratase
- Gene
- med-ORF16
- Organism
- Streptomyces sp. AM-7161
|
1uniprot Cloning, sequencing and heterologous expression of the medermycin biosynthetic gene cluster of Streptomyces sp. AM-7161: towards comparative analysis of the benzoisochromanequione gene clusters.(Microbiology (Mosc.)) [2003] |
|
12
|
Q83WG1_9ACTO (Q83WG1) |
|
(2 hsp) |
1e-131 |
474 |
53% |
|
- Product
- 2,3-dehydratase
- Gene
- staJ
- Organism
- Streptomyces sp. TP-A0274
|
1uniprot Direct formation of chromopyrrolic acid from indole-3-pyruvic acid by StaD, a novel hemoprotein in indolocarbazole biosynthesis.(Tetrahedron Lett.) [2006] | 2uniprot Biosynthesis of heterocyclic antibiotics in actinomycetes and an approach to synthesize the natural compounds.(Nihon Hosenkin Gakkaishi) [2006] | 3uniprot[Pubmed] 12617516 [Medline] 22504382 Cloning of the staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274 and its heterologous expression in Streptomyces lividans.(J. Antibiot.) [2002] | 4uniprot Characterization of the biosynthetic gene cluster of rebecamycin from Lechevalieria aerocolonigenes ATCC 39243.(Biosci. Biotechnol. Biochem.) [2003] | 5uniprot[Pubmed] 16195595 Cytochrome P450 homolog is responsible for C-N bond formation between aglycone and deoxysugar in the staurosporine biosynthesis of Streptomyces sp. TP-A0274.(Biosci. Biotechnol. Biochem.) [2005] | [pubmed all]
|
13
|
D7BZT9_STRBB (D7BZT9) |
|
|
1e-131 |
473 |
53% |
|
- Product
- NDP-hexose 23-dehydratase
- Gene
- SBI_06874
- Organism
- Streptomyces bingchenggensis (strain BCW-1)
|
1uniprot[Pubmed] 20581206 Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010] |
|
14
|
E9L1Q9_9ZZZZ (E9L1Q9) |
|
|
1e-130 |
470 |
53% |
|
- Product
- Putative uncharacterized protein
- Gene
- CA915-17
- Organism
- uncultured organism CA915
|
1uniprot[Pubmed] 20945895 Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010] |
|
15
|
Q9ZGC4_STRCY (Q9ZGC4) |
|
|
1e-130 |
468 |
54% |
|
- Product
- NDP-hexose 2,3-dehydratase homolog
- Gene
- lanS
- Organism
- Streptomyces cyanogenus
|
1uniprot[Pubmed] 9933932 [Medline] 99132695 Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin biosynthesis.(FEMS Microbiol. Lett.) [1999] |
|
16
|
D1A611_THECD (D1A611) |
|
(2 hsp) |
1e-130 |
468 |
56% |
|
- Product
- NDP-hexose 23-dehydratase
- Gene
- Tcur_2760
- Organism
- Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
|
1uniprot Complete genome sequence of Thermomonospora curvata type strain (B9).(Stand. Genomic Sci.) [2011] |
|
17
|
C4NYM3_9ACTO (C4NYM3) |
|
|
1e-129 |
467 |
52% |
|
- Product
- SaqS
- Gene
- saqS
- Organism
- Micromonospora sp. Tu 6368
|
1uniprot[Pubmed] 17497146 A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007] | 2uniprot[Pubmed] 19384899 Cloning and sequencing of the biosynthetic gene cluster for saquayamycin z and galtamycin B and the elucidation of the assembly of their saccharide chains.(Chembiochem) [2009] | [pubmed all]
|
19
|
O54255_STRNO (O54255) |
|
|
1e-129 |
466 |
54% |
|
- Product
- SnogH
- Gene
- snogH
- Organism
- Streptomyces nogalater
|
1uniprot[Pubmed] 8668120 [Medline] 96242142 A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.(Mol. Gen. Genet.) [1996] | 2uniprot[Pubmed] 9349712 [Medline] 98007868 Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.(Mol. Gen. Genet.) [1997] | 3uniprot[Pubmed] 8760909 [Medline] 96349102 Production of hybrid anthracycline antibiotics by heterologous expression of Streptomyces nogalater nogalamycin biosynthesis genes.(Microbiology) [1996] | [pubmed all]
|
20
|
D8HZB0_AMYMU (D8HZB0) |
|
|
1e-129 |
466 |
52% |
|
- Product
- NDP-hexose 2,3-dehydratase
- Gene
- AMED_0645
- Organism
- Amycolatopsis mediterranei (strain U-32)
|
1uniprot[Pubmed] 20567260 Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010] |
|
21
|
Q9AE03_AMYMD (Q9AE03) |
|
|
1e-129 |
466 |
52% |
|
- Product
- Putative 2,3-dehydratase
- Gene
-
- Organism
- Amycolatopsis mediterranei
Nocardia mediterranei
|
1uniprot[Pubmed] 9512878 [Medline] 98174059 Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699.(Chem. Biol.) [1998] | 2uniprot[Pubmed] 9497318 [Medline] 98165773 3-amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the formation of the precursor of mC7N units in rifamycin and related antibiotics.(J. Biol. Chem.) [1998] | 3uniprot[Pubmed] 11278540 [Medline] 21201076 Mutational analysis and reconstituted expression of the biosynthetic genes involved in the formation of 3-amino-5-hydroxybenzoic acid, the starter unit of rifamycin biosynthesis in amycolatopsis Mediterranei S699.(J. Biol. Chem.) [2001] | [pubmed all]
|
24
|
Q9ALN6_9PSEU (Q9ALN6) |
|
(2 hsp) |
1e-127 |
458 |
52% |
|
- Product
- Probable NDP-hexose-2,3-dehydratase
- Gene
- spnO
- Organism
- Saccharopolyspora spinosa
|
1uniprot[Pubmed] 11358695 [Medline] 21257765 Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa.(Chem. Biol.) [2001] |
|
26
|
Q9S0P1_STRAW (Q9S0P1) |
|
|
1e-126 |
457 |
53% |
|
- Product
- dTDP-4-keto-6-deoxy-L-hexose2,3-dehydratase
- Gene
- aveBVI
SAV950 SAV_950
- Organism
- Streptomyces avermitilis
|
1uniprot[Pubmed] 10449723 [Medline] 99380548 Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis.(Proc. Natl. Acad. Sci. U.S.A.) [1999] | 2uniprot[Pubmed] 11572948 [Medline] 21477403 Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.(Proc. Natl. Acad. Sci. U.S.A.) [2001] | 3uniprot[Pubmed] 12692562 [Medline] 22608306 Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis.(Nat. Biotechnol.) [2003] | [pubmed all]
|
27
|
D8I4I8_AMYMU (D8I4I8) |
|
(2 hsp) |
1e-126 |
456 |
54% |
|
- Product
- NDP-hexose 23-dehydratase
- Gene
- AMED_5402
- Organism
- Amycolatopsis mediterranei (strain U-32)
|
1uniprot[Pubmed] 20567260 Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010] |
|
28
|
C9YYJ0_STRSW (C9YYJ0) |
|
|
1e-126 |
456 |
54% |
|
- Product
- Putative NDP-hexose 2,3-dehydratase
- Gene
- SCAB_83991
- Organism
- Streptomyces scabies (strain 87.22)
Streptomyces scabiei
|
1uniprot[Pubmed] 20064060 Streptomyces scabies 87-22 contains a coronafacic acid-like biosynthetic cluster that contributes to plant-microbe interactions.(Mol. Plant Microbe Interact.) [2010] |
|
29
|
Q3S871_9ACTO (Q3S871) |
|
(2 hsp) |
1e-125 |
455 |
54% |
|
- Product
- 2,3-dehydratase
- Gene
-
- Organism
- Streptomyces neyagawaensis
|
1uniprot[Pubmed] 16207901 Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449.(Microbiology) [2005] |
|
30
|
Q67G51_9ACTO (Q67G51) |
|
|
1e-125 |
454 |
54% |
|
- Product
- 2,3-hexose dehydratase
- Gene
-
- Organism
- Streptomyces griseoruber
|
1uniprot[Pubmed] 15271354 The hedamycin locus implicates a novel aromatic PKS priming mechanism.(Chem. Biol.) [2004] |
|
31
|
B7T1A4_9BACT (B7T1A4) |
|
(3 hsp) |
1e-125 |
454 |
51% |
|
- Product
- Veg32
- Gene
- veg32
- Organism
- uncultured soil bacterium
|
1uniprot[Pubmed] 18987322 Cloning and characterization of new glycopeptide gene clusters found in an environmental DNA megalibrary.(Proc. Natl. Acad. Sci. U.S.A.) [2008] |
|
32
|
E9L1N4_9ZZZZ (E9L1N4) |
|
(3 hsp) |
1e-125 |
454 |
52% |
|
- Product
- Putative uncharacterized protein
- Gene
- CA878-35
- Organism
- uncultured organism CA878
|
1uniprot[Pubmed] 20945895 Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010] |
|
33
|
Q4JHQ4_9PSEU (Q4JHQ4) |
|
|
1e-125 |
453 |
51% |
|
- Product
- BusO
- Gene
- busO
- Organism
- Saccharopolyspora pogona
|
1uniprot[Pubmed] 16179985 Butenyl-spinosyns, a natural example of genetic engineering of antibiotic biosynthetic genes.(J. Ind. Microbiol. Biotechnol.) [2006] |
|
36
|
B3TMP2_9ACTO (B3TMP2) |
|
|
1e-125 |
452 |
52% |
|
- Product
- Sugar 2,3-dehydratase
- Gene
- KijB1
- Organism
- Actinomadura kijaniata
|
1uniprot[Pubmed] 17985890 Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007] |
|
37
|
Q2HR51_9ACTO (Q2HR51) |
|
|
1e-124 |
451 |
51% |
|
- Product
- Putative NDP-hexose 2, 3-dehydratase
- Gene
- schS2
- Organism
- Streptomyces sp. SCC 2136
|
1uniprot Angucyclines Sch 47554 and Sch 47555 from Streptomyces sp. SCC-2136: Cloning, Sequencing, and Characterization.(Mol. Cells) [2006] | 2uniprot Molecular cloning and characterization of biosynthetic genes cluster of Sch 47554 from Streptomyces sp. SCC 2136. [2004] |
|
40
|
Q9L4S4_STRFR (Q9L4S4) |
|
(3 hsp) |
1e-124 |
450 |
51% |
|
- Product
- NDP-hexose 2,3-dehydratase UrdS
- Gene
- urdS
- Organism
- Streptomyces fradiae
Streptomyces roseoflavus
|
1uniprot[Pubmed] 11094336 [Medline] 20547803 The NDP-sugar co-substrate concentration and the enzyme expression level influence the substrate specificity of glycosyltransferases: cloning and characterization of deoxysugar biosynthetic genes of the urdamycin biosynthetic gene cluster.(Chem. Biol.) [2000] |
|
41
|
D7CFD0_STRBB (D7CFD0) |
|
(3 hsp) |
1e-124 |
449 |
52% |
|
- Product
- NDP-hexose 23-dehydratase
- Gene
- SBI_01545
- Organism
- Streptomyces bingchenggensis (strain BCW-1)
|
1uniprot[Pubmed] 20581206 Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010] |
|
42
|
Q8KNC9_MICEC (Q8KNC9) |
|
|
1e-124 |
449 |
54% |
|
- Product
- CalS14
- Gene
- calS14
- Organism
- Micromonospora echinospora
Micromonospora purpurea
|
1uniprot[Pubmed] 12183629 [Medline] 22171414 The calicheamicin gene cluster and its iterative type I enediyne PKS.(Science) [2002] |
|
43
|
F2RC29_STRVP (F2RC29) |
|
(3 hsp) |
1e-124 |
448 |
52% |
|
- Product
- 2,3-dehydratase
- Gene
- SVEN_5994
- Organism
- Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
|
1uniprot[Pubmed] 21463507 Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes.(BMC Genomics) [2011] |
|
46
|
Q2PC37_STRAH (Q2PC37) |
|
(3 hsp) |
1e-122 |
444 |
53% |
|
- Product
- Putative TDP-glucose-2,3-dehydratase
- Gene
- rubN3
- Organism
- Streptomyces achromogenes subsp. rubradiris
|
1uniprot[Pubmed] 9387157 [Medline] 98048398 Identification of a gene cluster of biosynthetic genes of rubradirin substructures in S. achromogenes var. rubradiris NRRL3061.(Mol. Cells) [1997] | 2uniprot[Pubmed] 12889805 [Medline] 22771458 Functional identification of rub52 gene involved in the biosynthesis of rubradirin.(Biotechnol. Lett.) [2003] | [pubmed all]
|
47
|
O52793_AMYOR (O52793) |
|
(3 hsp) |
1e-122 |
444 |
50% |
|
- Product
- PCZA361.3
- Gene
-
- Organism
- Amycolatopsis orientalis
Nocardia orientalis
|
1uniprot[Pubmed] 9545426 [Medline] 98212597 Sequencing and analysis of genes involved in the biosynthesis of a vancomycin group antibiotic.(Chem. Biol.) [1998] |
|
48
|
Q939X7_9PSEU (Q939X7) |
|
(3 hsp) |
1e-122 |
443 |
51% |
|
- Product
- Putative NDP-hexose 2,3-dehydratase
- Gene
- dvaA
- Organism
- Amycolatopsis balhimycina
|
1uniprot[Pubmed] 10390204 [Medline] 99318579 Identification and analysis of the balhimycin biosynthetic gene cluster and its use for manipulating glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908.(Antimicrob. Agents Chemother.) [1999] | 2uniprot[Pubmed] 11932455 [Medline] 21930292 Nonribosomal biosynthesis of vancomycin-type antibiotics: a heptapeptide backbone and eight peptide synthetase modules.(Microbiology) [2002] | 3uniprot[Pubmed] 11495926 [Medline] 21486455 A polyketide synthase in glycopeptide biosynthesis: the biosynthesis of the non-proteinogenic amino acid (S)-3,5-dihydroxyphenylglycine.(J. Biol. Chem.) [2001] | 4uniprot[Pubmed] 12404385 The biosynthesis of vancomycin-type glycopeptide antibiotics - the order of cyclization steps.(Angew. Chem. Int. Ed. Engl.) [2001] | 5uniprot[Pubmed] 11880037 [Medline] 21869276 Glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908: function of a halogenase and a haloperoxidase/perhydrolase.(Chem. Biol.) [2002] | 6uniprot Precursor-directed biosynthesis for the generation of novel glycopetides.(Ernst Schering Res. Found. Workshop) [2005] | [pubmed all]
|
49
|
P95833_STRPE (P95833) |
|
(2 hsp) |
1e-122 |
443 |
49% |
|
- Product
- Doxorubicin biosynthesis protein DnmT
- Gene
- dnmT
- Organism
- Streptomyces peucetius
|
1uniprot[Pubmed] 8955419 [Medline] 97113559 Enhanced antibiotic production by manipulation of the Streptomyces peucetius dnrH and dnmT genes involved in doxorubicin (adriamycin) biosynthesis.(J. Bacteriol.) [1996] | 2uniprot[Pubmed] 9864344 [Medline] 99084971 Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene.(J. Bacteriol.) [1999] | [pubmed all]
|
50
|
Q2I757_9ACTO (Q2I757) |
|
|
1e-121 |
441 |
51% |
|
- Product
- PlaA2
- Gene
- plaA2
STTU_1456
- Organism
- Streptomyces sp. Tu6071
|
1uniprot[Pubmed] 16632249 Biosynthesis of the terpene phenalinolactone in Streptomyces sp. Tu6071: analysis of the gene cluster and generation of derivatives.(Chem. Biol.) [2006] |
|
51
|
Q845B8_STRAH (Q845B8) |
|
(3 hsp) |
1e-121 |
439 |
53% |
|
- Product
- DTDP-glucose-2,3-dehydratase
- Gene
- rub52
- Organism
- Streptomyces achromogenes
|
1uniprot Biosynthesis of Rubranitrose from the Rubradirin Producer, Streptomyces achromogenes var rubradiris NRRL 3061. [2002] |
|
52
|
O50540_SACER (O50540) |
|
(3 hsp) |
1e-120 |
438 |
50% |
|
- Product
- Putative 2,3 dehydratase
- Gene
- EryBVI
- Organism
- Saccharopolyspora erythraea
Streptomyces erythraeus
|
1uniprot[Pubmed] 9393448 [Medline] 98055166 Analysis of seven genes from the eryAI-eryK region of the erythromycin biosynthetic gene cluster in Saccharopolyspora erythraea.(Mol. Gen. Genet.) [1997] |
|
54
|
A4F7N4_SACEN (A4F7N4) |
|
(3 hsp) |
1e-120 |
437 |
50% |
|
- Product
- NDP-4-keto-6-deoxy-glucose 2,3-dehydratase
- Gene
- eryBVI
SACE_0717
- Organism
- Saccharopolyspora erythraea (strain NRRL 23338)
|
1uniprot[Pubmed] 17369815 Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007] |
|
55
|
B5L6M2_MICCH (B5L6M2) |
|
|
1e-120 |
436 |
49% |
|
- Product
- 2,3-hexose dehydratase
- Gene
-
- Organism
- Micromonospora chalcea
|
1uniprot[Pubmed] 18586939 Cloning and characterization of the tetrocarcin A gene cluster from Micromonospora chalcea NRRL 11289 reveals a highly conserved strategy for tetronate biosynthesis in spirotetronate antibiotics.(J. Bacteriol.) [2008] |
|
56
|
O33941_SACER (O33941) |
|
(3 hsp) |
1e-120 |
435 |
50% |
|
- Product
- EryBVI
- Gene
- eryBVI
- Organism
- Saccharopolyspora erythraea
Streptomyces erythraeus
|
1uniprot[Pubmed] 9353926 [Medline] 98015410 Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production.(Microbiology) |
|
58
|
Q0R4N9_STRAT (Q0R4N9) |
|
|
1e-119 |
433 |
54% |
|
- Product
- ChlC3
- Gene
-
- Organism
- Streptomyces antibioticus
|
1uniprot[Pubmed] 16793515 Genetic characterization of the chlorothricin gene cluster as a model for spirotetronate antibiotic biosynthesis.(Chem. Biol.) [2006] |
|
62
|
B0LJ28_9ACTO (B0LJ28) |
|
|
1e-118 |
430 |
50% |
|
- Product
- Lct45
- Gene
- lct45
- Organism
- Streptomyces rishiriensis
|
1uniprot[Pubmed] 18070976 Biosynthetic investigations of lactonamycin and lactonamycin z: cloning of the biosynthetic gene clusters and discovery of an unusual starter unit.(Antimicrob. Agents Chemother.) [2008] |
|
63
|
Q30CR3_STRAU (Q30CR3) |
|
(2 hsp) |
1e-118 |
429 |
50% |
|
- Product
- LipDig5
- Gene
- lipDig5
- Organism
- Streptomyces aureofaciens
|
1uniprot[Pubmed] 16723573 Biosynthetic gene cluster for the polyenoyltetramic acid alpha-lipomycin.(Antimicrob. Agents Chemother.) [2006] |
|
65
|
E5DUG9_9NOCA (E5DUG9) |
|
(2 hsp) |
1e-117 |
426 |
48% |
|
- Product
- NocS5
- Gene
- nocS5
- Organism
- Nocardia sp. ATCC 202099
|
1uniprot[Pubmed] 20473441 Moving posttranslational modifications forward to biosynthesize the glycosylated thiopeptide nocathiacin I in Nocardia sp. ATCC202099.(Mol. Biosyst.) [2010] |
|
67
|
D9UBQ2_STRPR (D9UBQ2) |
|
(2 hsp) |
1e-117 |
426 |
50% |
|
- Product
- Putative NDP-hexose 2,3-dehydratase
- Gene
- cpp32
- Organism
- Streptomyces pristinaespiralis
|
1uniprot[Pubmed] 21342465 Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011] |
|
69
|
Q0H2W5_9ACTO (Q0H2W5) |
|
(3 hsp) |
1e-116 |
423 |
50% |
|
- Product
- Probable NDP-hexose-2,3-dehydratase
- Gene
- atS14
- Organism
- Actinomadura melliaura
|
1uniprot[Pubmed] 16873021 Deciphering indolocarbazole and enediyne aminodideoxypentose biosynthesis through comparative genomics: insights from the AT2433 biosynthetic locus.(Chem. Biol.) [2006] |
|
71
|
D1GLT9_9ACTO (D1GLT9) |
|
(3 hsp) |
1e-114 |
418 |
51% |
|
- Product
- NDP-hexose-2,3-dehydratase
- Gene
- slgS3
- Organism
- Streptomyces lydicus
|
1uniprot Deciphering biosynthesis of the RNA polymerase inhibitor streptolydigin and generation of glycosylated derivatives.(Chem. Biol.) [2009] |
|
72
|
Q2J5G0_FRASC (Q2J5G0) |
|
|
1e-114 |
417 |
49% |
|
- Product
- NDP-hexose 2,3-dehydratase
- Gene
- Francci3_4134
- Organism
- Frankia sp. (strain CcI3)
|
1uniprot[Pubmed] 17151343 Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007] |
|
73
|
D7B006_NOCDD (D7B006) |
|
|
1e-113 |
414 |
51% |
|
- Product
- NDP-hexose 23-dehydratase
- Gene
- Ndas_4708
- Organism
- Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei
|
1uniprot Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010] |
|
74
|
C4XJ85_DESMR (C4XJ85) |
|
|
1e-113 |
413 |
48% |
|
- Product
- NDP-hexose 2,3-dehydratase
- Gene
- DMR_07580
- Organism
- Desulfovibrio magneticus (strain ATCC 700980 / DSM 13731 / RS-1)
|
1uniprot[Pubmed] 19675025 Whole genome sequence of Desulfovibrio magneticus strain RS-1 revealed common gene clusters in magnetotactic bacteria.(Genome Res.) [2009] |
|
75
|
A8Y8H1_STRAM (A8Y8H1) |
|
(2 hsp) |
1e-113 |
412 |
51% |
|
- Product
- Probable NDP-hexose dehydratase
- Gene
- srm7
- Organism
- Streptomyces ambofaciens
|
1uniprot Organization of the biosynthetic gene cluster for the macrolide antibiotic spiramycin in Streptomyces ambofaciens.(Microbiology (Mosc.)) [2007] |
|
76
|
C7MX48_SACVD (C7MX48) |
|
|
1e-113 |
412 |
49% |
|
- Product
- NDP-hexose 2,3-dehydratase
- Gene
- Svir_29870
- Organism
- Saccharomonospora viridis (strain ATCC 15386 / DSM 43017 / JCM 3036 / NBRC 12207 / P101)
|
1uniprot Complete genome sequence of Saccharomonospora viridis type strain (P101T).(Stand. Genomic Sci.) [2009] |
|
78
|
D5SL06_STRCL (D5SL06) |
|
(2 hsp) |
1e-112 |
410 |
45% |
|
- Product
- Staurosporine biosynthesis 2,3-dehydratase StaJ
- Gene
- staJ
SCLAV_p1113
- Organism
- Streptomyces clavuligerus ATCC 27064
|
1uniprot The sequence of a 1.8 Mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.(Genome Biol. Evol.) [2010] |
|
80
|
Q8VWC0_9ACTO (Q8VWC0) |
|
|
1e-111 |
408 |
51% |
|
- Product
- AclN
- Gene
- aclN
- Organism
- Streptomyces galilaeus
|
1uniprot[Pubmed] 12399480 [Medline] 22286521 Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus.(J. Bacteriol.) [2002] |
|
81
|
D7RFL3_AMYOR (D7RFL3) |
|
(3 hsp) |
1e-111 |
407 |
50% |
|
- Product
- Putative sugar 2,3-dehydratase
- Gene
- bexV
- Organism
- Amycolatopsis orientalis subsp. vinearia
|
1uniprot[Pubmed] 20443562 A biosynthetic pathway for BE-7585A, a 2-thiosugar-containing angucycline-type natural product.(J. Am. Chem. Soc.) [2010] |
|
82
|
Q9ZA32_STRVN (Q9ZA32) |
|
(2 hsp) |
1e-111 |
405 |
51% |
|
- Product
- Putative dTDP-4-keto-6-deoxyglucose-3,5-epimerase
- Gene
- gra-orf27
- Organism
- Streptomyces violaceoruber
|
1uniprot[Pubmed] 2583128 [Medline] 90060034 Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber Tu22.(EMBO J.) [1989] | 2uniprot[Pubmed] 7476861 [Medline] 96027933 Identification of Streptomyces violaceoruber Tu22 genes involved in the biosynthesis of granaticin.(Mol. Gen. Genet.) [1995] | 3uniprot[Pubmed] 9831526 [Medline] 99051446 The granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tu22: sequence analysis and expression in a heterologous host.(Chem. Biol.) [1998] | [pubmed all]
|
85
|
Q64Y66_BACFR (Q64Y66) |
|
(2 hsp) |
1e-110 |
402 |
43% |
|
- Product
- Putative dNDP-4-keto-6-deoxy-glucose-2,3-dehydratase
- Gene
- BF0809
- Organism
- Bacteroides fragilis
|
1uniprot[Pubmed] 15466707 Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation.(Proc. Natl. Acad. Sci. U.S.A.) [2004] |
|
87
|
Q9JN57_STRFR (Q9JN57) |
|
(2 hsp) |
1e-106 |
390 |
48% |
|
- Product
- TylCVI
- Gene
- tylCVI
- Organism
- Streptomyces fradiae
Streptomyces roseoflavus
|
1uniprot[Pubmed] 7984112 [Medline] 95075319 Analysis of five tylosin biosynthetic genes from the tyllBA region of the Streptomyces fradiae genome.(Mol. Microbiol.) [1994] | 2uniprot[Pubmed] 10467127 [Medline] 99398833 Multiple regulatory genes in the tylosin biosynthetic cluster of Streptomyces fradiae.(Chem. Biol.) [1999] | 3uniprot[Pubmed] 10658660 [Medline] 20121747 The mycarose-biosynthetic genes of Streptomyces fradiae, producer of tylosin.(Microbiology) [2000] | [pubmed all]
|
88
|
Q53880_STRS5 (Q53880) |
|
(2 hsp) |
1e-104 |
383 |
46% |
|
- Product
- Putative uncharacterized protein
- Gene
-
- Organism
- Streptomyces sp. (strain C5)
|
1uniprot[Pubmed] 8655529 [Medline] 96236066 Cloning, sequencing, and analysis of aklaviketone reductase from Streptomyces sp. strain C5.(J. Bacteriol.) [1996] |
|
89
|
A0M305_GRAFK (A0M305) |
|
(2 hsp) |
1e-104 |
382 |
39% |
|
- Product
- NDP-hexose 2,3-dehydratase
- Gene
- GFO_2035
- Organism
- Gramella forsetii (strain KT0803)
|
1uniprot[Pubmed] 17107561 Whole genome analysis of the marine Bacteroidetes'Gramella forsetii' reveals adaptations to degradation of polymeric organic matter.(Environ. Microbiol.) [2006] |
|
90
|
Q83X51_STRRO (Q83X51) |
|
(2 hsp) |
1e-103 |
381 |
50% |
|
- Product
- Putative NDP-4-keto-6-deoxyhexose 2,3-dehydratase
- Gene
- lkmBVI
- Organism
- Streptomyces rochei
Streptomyces parvullus
|
1uniprot[Pubmed] 12791134 [Medline] 22676866 The large linear plasmid pSLA2-L of Streptomyces rochei has an unusually condensed gene organization for secondary metabolism.(Mol. Microbiol.) [2003] | 2uniprot[Pubmed] 10954087 [Medline] 20408175 Cloning and analysis of the replication origin and the telomeres of the large linear plasmid pSLA2-L in Streptomyces rochei.(Mol. Gen. Genet.) [2000] | 3uniprot[Pubmed] 10767533 [Medline] 20231737 Identification of two polyketide synthase gene clusters on the linear plasmid pSLA2-L in Streptomyces rochei.(Gene) [2000] | 4uniprot[Pubmed] 9836424 [Medline] 99053144 Physical mapping of the linear plasmid pSLA2-L and localization of the eryAI and actI homologs.(Biosci. Biotechnol. Biochem.) [1998] | [pubmed all]
|
91
|
Q9AL96_9ACTO (Q9AL96) |
|
|
1e-103 |
380 |
48% |
|
- Product
- NDP-hexose 2,3-dehydratase
- Gene
- jadO
- Organism
- Streptomyces venezuelae
|
1uniprot[Pubmed] 11932454 [Medline] 21930291 Biosynthesis of the dideoxysugar component of jadomycin B: genes in the jad cluster of Streptomyces venezuelae ISP5230 for L-digitoxose assembly and transfer to the angucycline aglycone.(Microbiology) [2002] |
|
94
|
Q5Y9H9_9ACTO (Q5Y9H9) |
|
|
1e-101 |
375 |
45% |
|
- Product
- Deoxyhexose dehydratase
- Gene
- eryBVI
- Organism
- Aeromicrobium erythreum
|
1uniprot[Pubmed] 15257441 The erythromycin biosynthetic gene cluster of Aeromicrobium erythreum.(J. Ind. Microbiol. Biotechnol.) [2004] |
|
95
|
B1VRP4_STRGG (B1VRP4) |
|
(2 hsp) |
2e-98 |
364 |
48% |
|
- Product
- Putative NDP-deoxyglucose-2,3-dehydratase
- Gene
- SGR_633
- Organism
- Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
|
1uniprot[Pubmed] 18375553 Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350.(J. Bacteriol.) [2008] |
|
98
|
C7G1S5_STRGR (C7G1S5) |
|
(2 hsp) |
7e-94 |
349 |
44% |
|
- Product
- Putative 2,3-dehydratase
- Gene
-
- Organism
- Streptomyces griseus
|
1uniprot Identification of the biosynthetic gene cluster of A-500359s in Streptomyces griseus SANK60196.(J. Antibiot.) [2009] |
|