BLAST table : Aver_00160

DB	UniProtKB

	accession	alignment	Evalue	Score	Ident.	link	product	gene	organism
1	Q9S0P1_STRAW (Q9S0P1)		0.0	957	100%	UniProt GenBank	dTDP-4-keto-6-deoxy-L-hexose2,3-dehydratase	aveBVI SAV950 SAV_950	Streptomyces avermitilis
2	Q9ZGC4_STRCY (Q9ZGC4)		1e-174	615	71%	UniProt GenBank	NDP-hexose 2,3-dehydratase homolog	lanS	Streptomyces cyanogenus
3	B8Y4F2_STRAU (B8Y4F2)		1e-163	580	68%	UniProt GenBank	Putative NDP-hexose 2,3-dehydratase	aur1S	Streptomyces aureofaciens
4	Q9L4S4_STRFR (Q9L4S4)		1e-162	577	64%	UniProt GenBank	NDP-hexose 2,3-dehydratase UrdS	urdS	Streptomyces fradiae Streptomyces roseoflavus
5	Q2HR51_9ACTO (Q2HR51)	(2 hsp)	1e-162	577	66%	UniProt GenBank	Putative NDP-hexose 2, 3-dehydratase	schS2	Streptomyces sp. SCC 2136
6	F2RC29_STRVP (F2RC29)		1e-161	572	62%	UniProt GenBank	2,3-dehydratase	SVEN_5994	Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
7	D7CFD0_STRBB (D7CFD0)		1e-159	567	66%	UniProt GenBank	NDP-hexose 23-dehydratase	SBI_01545	Streptomyces bingchenggensis (strain BCW-1)
8	C4NYM3_9ACTO (C4NYM3)	(2 hsp)	1e-158	561	67%	UniProt GenBank	SaqS	saqS	Micromonospora sp. Tu 6368
9	D7BZT9_STRBB (D7BZT9)	(2 hsp)	1e-156	555	63%	UniProt GenBank	NDP-hexose 23-dehydratase	SBI_06874	Streptomyces bingchenggensis (strain BCW-1)
10	Q7WT23_9ACTO (Q7WT23)	(2 hsp)	1e-156	555	62%	UniProt GenBank	NDP-deoxyglucose-2,3-dehydratase	med-ORF16	Streptomyces sp. AM-7161
11	A8M282_SALAI (A8M282)		1e-154	550	65%	UniProt GenBank	NDP-hexose 23-dehydratase	Sare_2340	Salinispora arenicola (strain CNS-205)
12	Q83WG1_9ACTO (Q83WG1)		1e-154	548	62%	UniProt GenBank	2,3-dehydratase	staJ	Streptomyces sp. TP-A0274
13	B7T1A4_9BACT (B7T1A4)	(2 hsp)	1e-154	548	63%	UniProt GenBank	Veg32	veg32	uncultured soil bacterium
14	F8STZ2_AMYOR (F8STZ2)		1e-152	543	61%	UniProt GenBank	NDP-hexose 2,3-dehydrolase	vcm19	Amycolatopsis orientalis Nocardia orientalis
15	O52793_AMYOR (O52793)	(3 hsp)	1e-152	542	63%	UniProt GenBank	PCZA361.3		Amycolatopsis orientalis Nocardia orientalis
16	Q939X7_9PSEU (Q939X7)	(2 hsp)	1e-151	540	60%	UniProt GenBank	Putative NDP-hexose 2,3-dehydratase	dvaA	Amycolatopsis balhimycina
17	E9L1N4_9ZZZZ (E9L1N4)	(2 hsp)	1e-151	540	59%	UniProt GenBank	Putative uncharacterized protein	CA878-35	uncultured organism CA878
18	E9L1G4_9ZZZZ (E9L1G4)		1e-149	532	58%	UniProt GenBank	Putative uncharacterized protein	CA37-20	uncultured organism CA37
19	A4X6Y2_SALTO (A4X6Y2)	(2 hsp)	1e-147	526	61%	UniProt GenBank	NDP-hexose 2,3-dehydratase	Strop_2181	Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
20	Q2I757_9ACTO (Q2I757)	(2 hsp)	1e-146	523	61%	UniProt GenBank	PlaA2	plaA2 STTU_1456	Streptomyces sp. Tu6071
21	B0LJ28_9ACTO (B0LJ28)	(2 hsp)	1e-145	519	64%	UniProt GenBank	Lct45	lct45	Streptomyces rishiriensis
22	E9L1Q9_9ZZZZ (E9L1Q9)	(2 hsp)	1e-145	518	61%	UniProt GenBank	Putative uncharacterized protein	CA915-17	uncultured organism CA915
23	Q845B8_STRAH (Q845B8)		1e-144	517	60%	UniProt GenBank	DTDP-glucose-2,3-dehydratase	rub52	Streptomyces achromogenes
24	Q2PC37_STRAH (Q2PC37)		1e-144	516	60%	UniProt GenBank	Putative TDP-glucose-2,3-dehydratase	rubN3	Streptomyces achromogenes subsp. rubradiris
25	D6AT93_STRFL (D6AT93)	(2 hsp)	1e-143	512	61%	UniProt GenBank	NDP-hexose 2,3-dehydratase UrdS	SSGG_05537	Streptomyces roseosporus NRRL 15998
26	D1A611_THECD (D1A611)		1e-142	509	60%	UniProt GenBank	NDP-hexose 23-dehydratase	Tcur_2760	Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
27	D9WEH4_9ACTO (D9WEH4)		1e-135	487	58%	UniProt GenBank	dTDP-4-keto-6-deoxy-L-hexose2,3-dehydratase	SSOG_02927	Streptomyces himastatinicus ATCC 53653
28	Q9AL96_9ACTO (Q9AL96)		1e-135	485	58%	UniProt GenBank	NDP-hexose 2,3-dehydratase	jadO	Streptomyces venezuelae
29	Q30CR3_STRAU (Q30CR3)		1e-130	471	59%	UniProt GenBank	LipDig5	lipDig5	Streptomyces aureofaciens
30	D5SL06_STRCL (D5SL06)		1e-127	459	52%	UniProt GenBank	Staurosporine biosynthesis 2,3-dehydratase StaJ	staJ SCLAV_p1113	Streptomyces clavuligerus ATCC 27064
31	B5H2L9_STRCL (B5H2L9)		1e-127	458	52%	UniProt GenBank	2,3-dehydratase	SSCG_05826	Streptomyces clavuligerus ATCC 27064
32	C0JWA9_9ACTO (C0JWA9)		1e-127	458	53%	UniProt GenBank	PokS3	pokS3	Streptomyces diastatochromogenes
33	Q93F99_STRAT (Q93F99)		1e-127	458	50%	UniProt GenBank	Sim20	sim20	Streptomyces antibioticus
34	B5G893_9ACTO (B5G893)		1e-126	455	56%	UniProt GenBank	dTDP-4-keto-6-deoxy-L-hexose2,3-dehydratase	SSBG_00501	Streptomyces sp. SPB74
35	Q9AMH2_STRAT (Q9AMH2)		1e-125	455	50%	UniProt GenBank	Putative dNDP-4-keto-6-deoxy-glucose-2,3-dehydratase SimB3	simB3	Streptomyces antibioticus
36	B1VRP4_STRGG (B1VRP4)		1e-125	454	59%	UniProt GenBank	Putative NDP-deoxyglucose-2,3-dehydratase	SGR_633	Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
37	D6MSX2_9ACTO (D6MSX2)		1e-123	447	51%	UniProt GenBank	SsfS3	ssfS3	Streptomyces sp. SF2575
38	Q194Q2_STRAA (Q194Q2)	(2 hsp)	1e-123	447	54%	UniProt GenBank	D-olivose, D-oliose and D-mycarose 2,3-dehydratase	mtmV	Streptomyces argillaceus
39	E0KQN4_STRVO (E0KQN4)		1e-122	443	54%	UniProt GenBank	NDP-hexose 23-dehydratase	StrviDRAFT_4961	Streptomyces violaceusniger Tu 4113
40	D5UX43_TSUPD (D5UX43)		1e-122	442	55%	UniProt GenBank	NDP-hexose 23-dehydratase	Tpau_3481	Tsukamurella paurometabola (strain ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040) Corynebacterium paurometabolum
41	D3CRC6_9ACTO (D3CRC6)	(2 hsp)	1e-121	441	51%	UniProt GenBank	NDP-hexose 23-dehydratase	FrEUN1fDRAFT_0124	Frankia sp. EUN1f
42	B3TMP2_9ACTO (B3TMP2)	(2 hsp)	1e-120	437	52%	UniProt GenBank	Sugar 2,3-dehydratase	KijB1	Actinomadura kijaniata
43	D8HZB0_AMYMU (D8HZB0)	(3 hsp)	1e-120	436	52%	UniProt GenBank	NDP-hexose 2,3-dehydratase	AMED_0645	Amycolatopsis mediterranei (strain U-32)
44	Q9AE03_AMYMD (Q9AE03)	(3 hsp)	1e-120	436	52%	UniProt GenBank	Putative 2,3-dehydratase		Amycolatopsis mediterranei Nocardia mediterranei
45	Q67G51_9ACTO (Q67G51)		1e-119	432	49%	UniProt GenBank	2,3-hexose dehydratase		Streptomyces griseoruber
46	B5L6M2_MICCH (B5L6M2)		1e-118	430	50%	UniProt GenBank	2,3-hexose dehydratase		Micromonospora chalcea
47	A8CAC1_9ACTO (A8CAC1)		1e-118	429	51%	UniProt GenBank	NDP-hexose 2,3-dehydratase/thioesterase		Streptomyces eurythermus
48	O54255_STRNO (O54255)		1e-118	429	52%	UniProt GenBank	SnogH	snogH	Streptomyces nogalater
49	Q76KZ0_STRHA (Q76KZ0)	(2 hsp)	1e-117	428	50%	UniProt GenBank	DTDP-4-keto-6-deoxyglucose 2,3-dehydratase	vinD	Streptomyces halstedii
50	P95833_STRPE (P95833)		1e-117	426	49%	UniProt GenBank	Doxorubicin biosynthesis protein DnmT	dnmT	Streptomyces peucetius
51	A8M6Z0_SALAI (A8M6Z0)	(3 hsp)	1e-116	424	52%	UniProt GenBank	NDP-hexose 23-dehydratase	Sare_1267	Salinispora arenicola (strain CNS-205)
52	D9UBQ2_STRPR (D9UBQ2)	(2 hsp)	1e-115	421	50%	UniProt GenBank	Putative NDP-hexose 2,3-dehydratase	cpp32	Streptomyces pristinaespiralis
53	B5HKI1_STRPR (B5HKI1)	(2 hsp)	1e-115	421	50%	UniProt GenBank	NDP-hexose 2,3-dehydratase	SSDG_05669	Streptomyces pristinaespiralis ATCC 25486
54	D8I4I8_AMYMU (D8I4I8)	(2 hsp)	1e-115	421	50%	UniProt GenBank	NDP-hexose 23-dehydratase	AMED_5402	Amycolatopsis mediterranei (strain U-32)
55	A8LZN2_SALAI (A8LZN2)		1e-115	420	49%	UniProt GenBank	NDP-hexose 23-dehydratase	Sare_2025	Salinispora arenicola (strain CNS-205)
56	Q9RR31_STRAT (Q9RR31)		1e-115	419	51%	UniProt GenBank	2,3-dehydratase	oleV	Streptomyces antibioticus
57	E5RLM8_9ACTO (E5RLM8)		1e-114	416	50%	UniProt GenBank	Putative NDP-hexose 2,3-dehydratase	pnxS3	Streptomyces sp. TA-0256
58	D6AXN3_9ACTO (D6AXN3)		1e-114	416	50%	UniProt GenBank	AclN	SSHG_05325	Streptomyces albus J1074
59	Q8KNC9_MICEC (Q8KNC9)	(2 hsp)	1e-113	415	49%	UniProt GenBank	CalS14	calS14	Micromonospora echinospora Micromonospora purpurea
60	Q9L6C6_STRAT (Q9L6C6)		1e-113	414	51%	UniProt GenBank	DTDP-4-keto-6-deoxyglucose 2,3-dehydratase		Streptomyces antibioticus
61	E5DUG9_9NOCA (E5DUG9)	(2 hsp)	1e-113	412	51%	UniProt GenBank	NocS5	nocS5	Nocardia sp. ATCC 202099
62	C7MX48_SACVD (C7MX48)	(2 hsp)	1e-112	411	51%	UniProt GenBank	NDP-hexose 2,3-dehydratase	Svir_29870	Saccharomonospora viridis (strain ATCC 15386 / DSM 43017 / JCM 3036 / NBRC 12207 / P101)
63	Q8VWC0_9ACTO (Q8VWC0)	(2 hsp)	1e-112	410	52%	UniProt GenBank	AclN	aclN	Streptomyces galilaeus
64	Q2J5G0_FRASC (Q2J5G0)		1e-112	410	50%	UniProt GenBank	NDP-hexose 2,3-dehydratase	Francci3_4134	Frankia sp. (strain CcI3)
65	Q70J94_STRGR (Q70J94)		1e-112	410	53%	UniProt GenBank	NDP-2,3-dehydratase	cmmV	Streptomyces griseus subsp. griseus
66	C4RP88_9ACTO (C4RP88)	(3 hsp)	1e-112	409	50%	UniProt GenBank	2,3-dehydratase	MCAG_03651	Micromonospora sp. ATCC 39149
67	D1GLT9_9ACTO (D1GLT9)	(2 hsp)	1e-111	406	51%	UniProt GenBank	NDP-hexose-2,3-dehydratase	slgS3	Streptomyces lydicus
68	D9T284_MICAI (D9T284)	(2 hsp)	1e-111	405	50%	UniProt GenBank	NDP-hexose 23-dehydratase	Micau_3987	Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
69	E8RWU5_MICSL (E8RWU5)	(2 hsp)	1e-111	405	50%	UniProt GenBank	NDP-hexose 23-dehydratase	ML5_4434	Micromonospora sp. (strain L5)
70	Q3S871_9ACTO (Q3S871)		1e-110	405	48%	UniProt GenBank	2,3-dehydratase		Streptomyces neyagawaensis
71	Q9ALN6_9PSEU (Q9ALN6)	(2 hsp)	1e-109	400	49%	UniProt GenBank	Probable NDP-hexose-2,3-dehydratase	spnO	Saccharopolyspora spinosa
72	Q9ZA32_STRVN (Q9ZA32)	(2 hsp)	1e-109	399	48%	UniProt GenBank	Putative dTDP-4-keto-6-deoxyglucose-3,5-epimerase	gra-orf27	Streptomyces violaceoruber
73	C9YYJ0_STRSW (C9YYJ0)		1e-108	395	49%	UniProt GenBank	Putative NDP-hexose 2,3-dehydratase	SCAB_83991	Streptomyces scabies (strain 87.22) Streptomyces scabiei
74	D7B006_NOCDD (D7B006)	(2 hsp)	1e-107	395	51%	UniProt GenBank	NDP-hexose 23-dehydratase	Ndas_4708	Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488) Actinomadura dassonvillei
75	Q4JHQ4_9PSEU (Q4JHQ4)	(2 hsp)	1e-107	393	49%	UniProt GenBank	BusO	busO	Saccharopolyspora pogona
76	E2NJ87_9BACE (E2NJ87)	(2 hsp)	1e-107	392	45%	UniProt GenBank	Putative uncharacterized protein	BACCELL_04373	Bacteroides cellulosilyticus DSM 14838
77	E3T4A5_9ACTO (E3T4A5)		1e-106	391	49%	UniProt GenBank	dTDP-4-keto-6-deoxyglucose 2,3-dehydratase	gra-orf27	Streptomyces vietnamensis
78	Q9JN57_STRFR (Q9JN57)	(3 hsp)	1e-106	391	50%	UniProt GenBank	TylCVI	tylCVI	Streptomyces fradiae Streptomyces roseoflavus
79	O50540_SACER (O50540)	(3 hsp)	1e-106	390	47%	UniProt GenBank	Putative 2,3 dehydratase	EryBVI	Saccharopolyspora erythraea Streptomyces erythraeus
80	D7RFL3_AMYOR (D7RFL3)	(2 hsp)	1e-106	390	50%	UniProt GenBank	Putative sugar 2,3-dehydratase	bexV	Amycolatopsis orientalis subsp. vinearia
81	A4F7N4_SACEN (A4F7N4)	(3 hsp)	1e-106	390	47%	UniProt GenBank	NDP-4-keto-6-deoxy-glucose 2,3-dehydratase	eryBVI SACE_0717	Saccharopolyspora erythraea (strain NRRL 23338)
82	Q64Y66_BACFR (Q64Y66)	(2 hsp)	1e-106	389	43%	UniProt GenBank	Putative dNDP-4-keto-6-deoxy-glucose-2,3-dehydratase	BF0809	Bacteroides fragilis
83	A8Y8H1_STRAM (A8Y8H1)	(2 hsp)	1e-106	389	49%	UniProt GenBank	Probable NDP-hexose dehydratase	srm7	Streptomyces ambofaciens
84	Q0H2W5_9ACTO (Q0H2W5)	(2 hsp)	1e-106	389	49%	UniProt GenBank	Probable NDP-hexose-2,3-dehydratase	atS14	Actinomadura melliaura
85	O33941_SACER (O33941)	(3 hsp)	1e-106	388	47%	UniProt GenBank	EryBVI	eryBVI	Saccharopolyspora erythraea Streptomyces erythraeus
86	Q9REU2_STRFR (Q9REU2)	(2 hsp)	1e-103	380	48%	UniProt GenBank	TDP-6-deoxy-4-ketohexose 2,3-dehydratase	tylCVI	Streptomyces fradiae Streptomyces roseoflavus
87	D2L2F5_9DELT (D2L2F5)	(2 hsp)	1e-102	377	46%	UniProt GenBank	NDP-hexose 23-dehydratase	DFW101DRAFT_0868	Desulfovibrio sp. FW1012B
88	Q0R4N9_STRAT (Q0R4N9)	(2 hsp)	1e-102	375	48%	UniProt GenBank	ChlC3		Streptomyces antibioticus
89	Q53880_STRS5 (Q53880)	(2 hsp)	1e-100	371	44%	UniProt GenBank	Putative uncharacterized protein		Streptomyces sp. (strain C5)
90	E1K295_DESFR (E1K295)	(2 hsp)	1e-100	371	45%	UniProt GenBank	NDP-hexose 23-dehydratase	DesfrDRAFT_3995	Desulfovibrio fructosovorans JJ
91	C4XJ85_DESMR (C4XJ85)		2e-99	367	46%	UniProt GenBank	NDP-hexose 2,3-dehydratase	DMR_07580	Desulfovibrio magneticus (strain ATCC 700980 / DSM 13731 / RS-1)
92	A0M305_GRAFK (A0M305)	(2 hsp)	1e-96	358	39%	UniProt GenBank	NDP-hexose 2,3-dehydratase	GFO_2035	Gramella forsetii (strain KT0803)
93	Q83X51_STRRO (Q83X51)	(2 hsp)	1e-94	352	46%	UniProt GenBank	Putative NDP-4-keto-6-deoxyhexose 2,3-dehydratase	lkmBVI	Streptomyces rochei Streptomyces parvullus
94	C6BTH7_DESAD (C6BTH7)	(3 hsp)	6e-92	342	40%	UniProt GenBank	NDP-hexose 23-dehydratase	Desal_3612	Desulfovibrio salexigens (strain ATCC 14822 / DSM 2638 / NCIB 8403 / VKM B-1763)
95	E1CG34_9ACTO (E1CG34)		3e-91	340	43%	UniProt GenBank	Putative NDP-hexose 2,3-dehydratase	capE	Streptomyces sp. SANK 62799
96	Q5Y9H9_9ACTO (Q5Y9H9)	(3 hsp)	5e-88	330	42%	UniProt GenBank	Deoxyhexose dehydratase	eryBVI	Aeromicrobium erythreum
97	C6Z1M2_9BACE (C6Z1M2)	(3 hsp)	5e-88	330	38%	UniProt GenBank	NDP-hexose 2,3-dehydratase	BSFG_00928	Bacteroides sp. 4_3_47FAA
98	D9VC38_9ACTO (D9VC38)		2e-85	321	44%	UniProt GenBank	Predicted protein	SSMG_03426	Streptomyces sp. AA4
99	C7G1S5_STRGR (C7G1S5)		2e-85	320	43%	UniProt GenBank	Putative 2,3-dehydratase		Streptomyces griseus
100	D6HPU9_9FIRM (D6HPU9)		1e-78	298	35%	UniProt GenBank	dTDP-4-keto-6-deoxy-L-hexose2,3-dehydratase	HMPREF0863_02019	Erysipelotrichaceae bacterium 5_2_54FAA

accession

alignment

Evalue

Score

Ident.

link

information

pubmed

Q9S0P1_STRAW
(Q9S0P1)

0.0

957

100%

Product: dTDP-4-keto-6-deoxy-L-hexose2,3-dehydratase
Gene: aveBVI
SAV950
SAV_950
Organism: Streptomyces avermitilis

[pubmed all]
1uniprot[Pubmed] 10449723 [Medline] 99380548 Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis.(Proc. Natl. Acad. Sci. U.S.A.) [1999]
2uniprot[Pubmed] 11572948 [Medline] 21477403 Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.(Proc. Natl. Acad. Sci. U.S.A.) [2001]
3uniprot[Pubmed] 12692562 [Medline] 22608306 Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis.(Nat. Biotechnol.) [2003]

Q9ZGC4_STRCY
(Q9ZGC4)

1e-174

615

71%

Product: NDP-hexose 2,3-dehydratase homolog
Gene: lanS
Organism: Streptomyces cyanogenus

1uniprot[Pubmed] 9933932 [Medline] 99132695
Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin biosynthesis.(FEMS Microbiol. Lett.) [1999]

B8Y4F2_STRAU
(B8Y4F2)

1e-163

580

68%

Product: Putative NDP-hexose 2,3-dehydratase
Gene: aur1S
Organism: Streptomyces aureofaciens

1uniprot[Pubmed] 20490753
Identification and characterization of an indigoidine-like gene for a blue pigment biosynthesis in Streptomyces aureofaciens CCM 3239.(Folia Microbiol. (Praha)) [2010]

Q9L4S4_STRFR
(Q9L4S4)

1e-162

577

64%

Product: NDP-hexose 2,3-dehydratase UrdS
Gene: urdS
Organism: Streptomyces fradiae
Streptomyces roseoflavus

1uniprot[Pubmed] 11094336 [Medline] 20547803
The NDP-sugar co-substrate concentration and the enzyme expression level influence the substrate specificity of glycosyltransferases: cloning and characterization of deoxysugar biosynthetic genes of the urdamycin biosynthetic gene cluster.(Chem. Biol.) [2000]

Q2HR51_9ACTO
(Q2HR51)

(2 hsp)

1e-162

577

66%

Product: Putative NDP-hexose 2, 3-dehydratase
Gene: schS2
Organism: Streptomyces sp. SCC 2136

1uniprot
Angucyclines Sch 47554 and Sch 47555 from Streptomyces sp. SCC-2136: Cloning, Sequencing, and Characterization.(Mol. Cells) [2006]

2uniprot
Molecular cloning and characterization of biosynthetic genes cluster of Sch 47554 from Streptomyces sp. SCC 2136. [2004]

F2RC29_STRVP
(F2RC29)

1e-161

572

62%

Product: 2,3-dehydratase
Gene: SVEN_5994
Organism: Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)

1uniprot[Pubmed] 21463507
Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes.(BMC Genomics) [2011]

D7CFD0_STRBB
(D7CFD0)

1e-159

567

66%

Product: NDP-hexose 23-dehydratase
Gene: SBI_01545
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

C4NYM3_9ACTO
(C4NYM3)

(2 hsp)

1e-158

561

67%

Product: SaqS
Gene: saqS
Organism: Micromonospora sp. Tu 6368

[pubmed all]
1uniprot[Pubmed] 17497146 A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]
2uniprot[Pubmed] 19384899 Cloning and sequencing of the biosynthetic gene cluster for saquayamycin z and galtamycin B and the elucidation of the assembly of their saccharide chains.(Chembiochem) [2009]

D7BZT9_STRBB
(D7BZT9)

(2 hsp)

1e-156

555

63%

Product: NDP-hexose 23-dehydratase
Gene: SBI_06874
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

Q7WT23_9ACTO
(Q7WT23)

(2 hsp)

1e-156

555

62%

Product: NDP-deoxyglucose-2,3-dehydratase
Gene: med-ORF16
Organism: Streptomyces sp. AM-7161

1uniprot
Cloning, sequencing and heterologous expression of the medermycin biosynthetic gene cluster of Streptomyces sp. AM-7161: towards comparative analysis of the benzoisochromanequione gene clusters.(Microbiology (Mosc.)) [2003]

Q83WG1_9ACTO
(Q83WG1)

1e-154

548

62%

Product: 2,3-dehydratase
Gene: staJ
Organism: Streptomyces sp. TP-A0274

[pubmed all]
1uniprot Direct formation of chromopyrrolic acid from indole-3-pyruvic acid by StaD, a novel hemoprotein in indolocarbazole biosynthesis.(Tetrahedron Lett.) [2006]
2uniprot Biosynthesis of heterocyclic antibiotics in actinomycetes and an approach to synthesize the natural compounds.(Nihon Hosenkin Gakkaishi) [2006]
3uniprot[Pubmed] 12617516 [Medline] 22504382 Cloning of the staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274 and its heterologous expression in Streptomyces lividans.(J. Antibiot.) [2002]
4uniprot Characterization of the biosynthetic gene cluster of rebecamycin from Lechevalieria aerocolonigenes ATCC 39243.(Biosci. Biotechnol. Biochem.) [2003]
5uniprot[Pubmed] 16195595 Cytochrome P450 homolog is responsible for C-N bond formation between aglycone and deoxysugar in the staurosporine biosynthesis of Streptomyces sp. TP-A0274.(Biosci. Biotechnol. Biochem.) [2005]

B7T1A4_9BACT
(B7T1A4)

(2 hsp)

1e-154

548

63%

Product: Veg32
Gene: veg32
Organism: uncultured soil bacterium

1uniprot[Pubmed] 18987322
Cloning and characterization of new glycopeptide gene clusters found in an environmental DNA megalibrary.(Proc. Natl. Acad. Sci. U.S.A.) [2008]

O52793_AMYOR
(O52793)

(3 hsp)

1e-152

542

63%

Product: PCZA361.3
Gene
Organism: Amycolatopsis orientalis
Nocardia orientalis

1uniprot[Pubmed] 9545426 [Medline] 98212597
Sequencing and analysis of genes involved in the biosynthesis of a vancomycin group antibiotic.(Chem. Biol.) [1998]

Q939X7_9PSEU
(Q939X7)

(2 hsp)

1e-151

540

60%

Product: Putative NDP-hexose 2,3-dehydratase
Gene: dvaA
Organism: Amycolatopsis balhimycina

[pubmed all]
1uniprot[Pubmed] 10390204 [Medline] 99318579 Identification and analysis of the balhimycin biosynthetic gene cluster and its use for manipulating glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908.(Antimicrob. Agents Chemother.) [1999]
2uniprot[Pubmed] 11932455 [Medline] 21930292 Nonribosomal biosynthesis of vancomycin-type antibiotics: a heptapeptide backbone and eight peptide synthetase modules.(Microbiology) [2002]
3uniprot[Pubmed] 11495926 [Medline] 21486455 A polyketide synthase in glycopeptide biosynthesis: the biosynthesis of the non-proteinogenic amino acid (S)-3,5-dihydroxyphenylglycine.(J. Biol. Chem.) [2001]
4uniprot[Pubmed] 12404385 The biosynthesis of vancomycin-type glycopeptide antibiotics - the order of cyclization steps.(Angew. Chem. Int. Ed. Engl.) [2001]
5uniprot[Pubmed] 11880037 [Medline] 21869276 Glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908: function of a halogenase and a haloperoxidase/perhydrolase.(Chem. Biol.) [2002]
6uniprot Precursor-directed biosynthesis for the generation of novel glycopetides.(Ernst Schering Res. Found. Workshop) [2005]

E9L1N4_9ZZZZ
(E9L1N4)

(2 hsp)

1e-151

540

59%

Product: Putative uncharacterized protein
Gene: CA878-35
Organism: uncultured organism CA878

1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]

E9L1G4_9ZZZZ
(E9L1G4)

1e-149

532

58%

Product: Putative uncharacterized protein
Gene: CA37-20
Organism: uncultured organism CA37

1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]

Q2I757_9ACTO
(Q2I757)

(2 hsp)

1e-146

523

61%

Product: PlaA2
Gene: plaA2
STTU_1456
Organism: Streptomyces sp. Tu6071

1uniprot[Pubmed] 16632249
Biosynthesis of the terpene phenalinolactone in Streptomyces sp. Tu6071: analysis of the gene cluster and generation of derivatives.(Chem. Biol.) [2006]

B0LJ28_9ACTO
(B0LJ28)

(2 hsp)

1e-145

519

64%

Product: Lct45
Gene: lct45
Organism: Streptomyces rishiriensis

1uniprot[Pubmed] 18070976
Biosynthetic investigations of lactonamycin and lactonamycin z: cloning of the biosynthetic gene clusters and discovery of an unusual starter unit.(Antimicrob. Agents Chemother.) [2008]

E9L1Q9_9ZZZZ
(E9L1Q9)

(2 hsp)

1e-145

518

61%

Product: Putative uncharacterized protein
Gene: CA915-17
Organism: uncultured organism CA915

1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]

Q845B8_STRAH
(Q845B8)

1e-144

517

60%

Product: DTDP-glucose-2,3-dehydratase
Gene: rub52
Organism: Streptomyces achromogenes

1uniprot
Biosynthesis of Rubranitrose from the Rubradirin Producer, Streptomyces achromogenes var rubradiris NRRL 3061. [2002]

Q2PC37_STRAH
(Q2PC37)

1e-144

516

60%

Product: Putative TDP-glucose-2,3-dehydratase
Gene: rubN3
Organism: Streptomyces achromogenes subsp. rubradiris

[pubmed all]
1uniprot[Pubmed] 9387157 [Medline] 98048398 Identification of a gene cluster of biosynthetic genes of rubradirin substructures in S. achromogenes var. rubradiris NRRL3061.(Mol. Cells) [1997]
2uniprot[Pubmed] 12889805 [Medline] 22771458 Functional identification of rub52 gene involved in the biosynthesis of rubradirin.(Biotechnol. Lett.) [2003]

D1A611_THECD
(D1A611)

1e-142

509

60%

Product: NDP-hexose 23-dehydratase
Gene: Tcur_2760
Organism: Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)

1uniprot
Complete genome sequence of Thermomonospora curvata type strain (B9).(Stand. Genomic Sci.) [2011]

Q9AL96_9ACTO
(Q9AL96)

1e-135

485

58%

Product: NDP-hexose 2,3-dehydratase
Gene: jadO
Organism: Streptomyces venezuelae

1uniprot[Pubmed] 11932454 [Medline] 21930291
Biosynthesis of the dideoxysugar component of jadomycin B: genes in the jad cluster of Streptomyces venezuelae ISP5230 for L-digitoxose assembly and transfer to the angucycline aglycone.(Microbiology) [2002]

Q30CR3_STRAU
(Q30CR3)

1e-130

471

59%

Product: LipDig5
Gene: lipDig5
Organism: Streptomyces aureofaciens

1uniprot[Pubmed] 16723573
Biosynthetic gene cluster for the polyenoyltetramic acid alpha-lipomycin.(Antimicrob. Agents Chemother.) [2006]

D5SL06_STRCL
(D5SL06)

1e-127

459

52%

Product: Staurosporine biosynthesis 2,3-dehydratase StaJ
Gene: staJ
SCLAV_p1113
Organism: Streptomyces clavuligerus ATCC 27064

1uniprot
The sequence of a 1.8 Mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.(Genome Biol. Evol.) [2010]

C0JWA9_9ACTO
(C0JWA9)

1e-127

458

53%

Product: PokS3
Gene: pokS3
Organism: Streptomyces diastatochromogenes

1uniprot[Pubmed] 19266534
Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009]

Q93F99_STRAT
(Q93F99)

1e-127

458

50%

Product: Sim20
Gene: sim20
Organism: Streptomyces antibioticus

1uniprot[Pubmed] 12115055 [Medline] 22109063
Cloning and analysis of the simocyclinone biosynthetic gene cluster of Streptomyces antibioticus Tu 6040.(Arch. Microbiol.) [2002]

Q9AMH2_STRAT
(Q9AMH2)

1e-125

455

50%

Product: Putative dNDP-4-keto-6-deoxy-glucose-2,3-dehydratase SimB3
Gene: simB3
Organism: Streptomyces antibioticus

1uniprot[Pubmed] 11959542 [Medline] 21955989
Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibiotic.(Antimicrob. Agents Chemother.) [2002]

B1VRP4_STRGG
(B1VRP4)

1e-125

454

59%

Product: Putative NDP-deoxyglucose-2,3-dehydratase
Gene: SGR_633
Organism: Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)

1uniprot[Pubmed] 18375553
Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350.(J. Bacteriol.) [2008]

D6MSX2_9ACTO
(D6MSX2)

1e-123

447

51%

Product: SsfS3
Gene: ssfS3
Organism: Streptomyces sp. SF2575

1uniprot[Pubmed] 19908837
Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.(J. Am. Chem. Soc.) [2009]

Q194Q2_STRAA
(Q194Q2)

(2 hsp)

1e-123

447

54%

Product: D-olivose, D-oliose and D-mycarose 2,3-dehydratase
Gene: mtmV
Organism: Streptomyces argillaceus

[pubmed all]
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]

B3TMP2_9ACTO
(B3TMP2)

(2 hsp)

1e-120

437

52%

Product: Sugar 2,3-dehydratase
Gene: KijB1
Organism: Actinomadura kijaniata

1uniprot[Pubmed] 17985890
Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007]

D8HZB0_AMYMU
(D8HZB0)

(3 hsp)

1e-120

436

52%

Product: NDP-hexose 2,3-dehydratase
Gene: AMED_0645
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

Q9AE03_AMYMD
(Q9AE03)

(3 hsp)

1e-120

436

52%

Product: Putative 2,3-dehydratase
Gene
Organism: Amycolatopsis mediterranei
Nocardia mediterranei

[pubmed all]
1uniprot[Pubmed] 9512878 [Medline] 98174059 Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699.(Chem. Biol.) [1998]
2uniprot[Pubmed] 9497318 [Medline] 98165773 3-amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the formation of the precursor of mC7N units in rifamycin and related antibiotics.(J. Biol. Chem.) [1998]
3uniprot[Pubmed] 11278540 [Medline] 21201076 Mutational analysis and reconstituted expression of the biosynthetic genes involved in the formation of 3-amino-5-hydroxybenzoic acid, the starter unit of rifamycin biosynthesis in amycolatopsis Mediterranei S699.(J. Biol. Chem.) [2001]

Q67G51_9ACTO
(Q67G51)

1e-119

432

49%

Product: 2,3-hexose dehydratase
Gene
Organism: Streptomyces griseoruber

1uniprot[Pubmed] 15271354
The hedamycin locus implicates a novel aromatic PKS priming mechanism.(Chem. Biol.) [2004]

B5L6M2_MICCH
(B5L6M2)

1e-118

430

50%

Product: 2,3-hexose dehydratase
Gene
Organism: Micromonospora chalcea

1uniprot[Pubmed] 18586939
Cloning and characterization of the tetrocarcin A gene cluster from Micromonospora chalcea NRRL 11289 reveals a highly conserved strategy for tetronate biosynthesis in spirotetronate antibiotics.(J. Bacteriol.) [2008]

O54255_STRNO
(O54255)

1e-118

429

52%

Product: SnogH
Gene: snogH
Organism: Streptomyces nogalater

[pubmed all]
1uniprot[Pubmed] 8668120 [Medline] 96242142 A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.(Mol. Gen. Genet.) [1996]
2uniprot[Pubmed] 9349712 [Medline] 98007868 Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.(Mol. Gen. Genet.) [1997]
3uniprot[Pubmed] 8760909 [Medline] 96349102 Production of hybrid anthracycline antibiotics by heterologous expression of Streptomyces nogalater nogalamycin biosynthesis genes.(Microbiology) [1996]

Q76KZ0_STRHA
(Q76KZ0)

(2 hsp)

1e-117

428

50%

Product: DTDP-4-keto-6-deoxyglucose 2,3-dehydratase
Gene: vinD
Organism: Streptomyces halstedii

1uniprot[Pubmed] 15112997
Cloning, sequencing, and functional analysis of the biosynthetic gene cluster of macrolactam antibiotic vicenistatin in Streptomyces halstedii.(Chem. Biol.) [2004]

P95833_STRPE
(P95833)

1e-117

426

49%

Product: Doxorubicin biosynthesis protein DnmT
Gene: dnmT
Organism: Streptomyces peucetius

[pubmed all]
1uniprot[Pubmed] 8955419 [Medline] 97113559 Enhanced antibiotic production by manipulation of the Streptomyces peucetius dnrH and dnmT genes involved in doxorubicin (adriamycin) biosynthesis.(J. Bacteriol.) [1996]
2uniprot[Pubmed] 9864344 [Medline] 99084971 Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene.(J. Bacteriol.) [1999]

D9UBQ2_STRPR
(D9UBQ2)

(2 hsp)

1e-115

421

50%

Product: Putative NDP-hexose 2,3-dehydratase
Gene: cpp32
Organism: Streptomyces pristinaespiralis

1uniprot[Pubmed] 21342465
Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011]

D8I4I8_AMYMU
(D8I4I8)

(2 hsp)

1e-115

421

50%

Product: NDP-hexose 23-dehydratase
Gene: AMED_5402
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

Q9RR31_STRAT
(Q9RR31)

1e-115

419

51%

Product: 2,3-dehydratase
Gene: oleV
Organism: Streptomyces antibioticus

1uniprot[Pubmed] 10770761 [Medline] 20233594
Identification and expression of genes involved in biosynthesis of L-oleandrose and its intermediate L-olivose in the oleandomycin producer Streptomyces antibioticus.(Antimicrob. Agents Chemother.) [2000]

Q8KNC9_MICEC
(Q8KNC9)

(2 hsp)

1e-113

415

49%

Product: CalS14
Gene: calS14
Organism: Micromonospora echinospora
Micromonospora purpurea

1uniprot[Pubmed] 12183629 [Medline] 22171414
The calicheamicin gene cluster and its iterative type I enediyne PKS.(Science) [2002]

Q9L6C6_STRAT
(Q9L6C6)

1e-113

414

51%

Product: DTDP-4-keto-6-deoxyglucose 2,3-dehydratase
Gene
Organism: Streptomyces antibioticus

1uniprot
Mechanism of the 2-deoxygenation step in the biosynthesis of the deoxyhexose moieties of the antibiotics granaticin and oleandomycin.(J. Am. Chem. Soc.) [1999]

E5DUG9_9NOCA
(E5DUG9)

(2 hsp)

1e-113

412

51%

Product: NocS5
Gene: nocS5
Organism: Nocardia sp. ATCC 202099

1uniprot[Pubmed] 20473441
Moving posttranslational modifications forward to biosynthesize the glycosylated thiopeptide nocathiacin I in Nocardia sp. ATCC202099.(Mol. Biosyst.) [2010]

C7MX48_SACVD
(C7MX48)

(2 hsp)

1e-112

411

51%

Product: NDP-hexose 2,3-dehydratase
Gene: Svir_29870
Organism: Saccharomonospora viridis (strain ATCC 15386 / DSM 43017 / JCM 3036 / NBRC 12207 / P101)

1uniprot
Complete genome sequence of Saccharomonospora viridis type strain (P101T).(Stand. Genomic Sci.) [2009]

Q8VWC0_9ACTO
(Q8VWC0)

(2 hsp)

1e-112

410

52%

Product: AclN
Gene: aclN
Organism: Streptomyces galilaeus

1uniprot[Pubmed] 12399480 [Medline] 22286521
Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus.(J. Bacteriol.) [2002]

Q2J5G0_FRASC
(Q2J5G0)

1e-112

410

50%

Product: NDP-hexose 2,3-dehydratase
Gene: Francci3_4134
Organism: Frankia sp. (strain CcI3)

1uniprot[Pubmed] 17151343
Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007]

D1GLT9_9ACTO
(D1GLT9)

(2 hsp)

1e-111

406

51%

Product: NDP-hexose-2,3-dehydratase
Gene: slgS3
Organism: Streptomyces lydicus

1uniprot
Deciphering biosynthesis of the RNA polymerase inhibitor streptolydigin and generation of glycosylated derivatives.(Chem. Biol.) [2009]

Q3S871_9ACTO
(Q3S871)

1e-110

405

48%

Product: 2,3-dehydratase
Gene
Organism: Streptomyces neyagawaensis

1uniprot[Pubmed] 16207901
Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449.(Microbiology) [2005]

Q9ALN6_9PSEU
(Q9ALN6)

(2 hsp)

1e-109

400

49%

Product: Probable NDP-hexose-2,3-dehydratase
Gene: spnO
Organism: Saccharopolyspora spinosa

1uniprot[Pubmed] 11358695 [Medline] 21257765
Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa.(Chem. Biol.) [2001]

Q9ZA32_STRVN
(Q9ZA32)

(2 hsp)

1e-109

399

48%

Product: Putative dTDP-4-keto-6-deoxyglucose-3,5-epimerase
Gene: gra-orf27
Organism: Streptomyces violaceoruber

[pubmed all]
1uniprot[Pubmed] 2583128 [Medline] 90060034 Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber Tu22.(EMBO J.) [1989]
2uniprot[Pubmed] 7476861 [Medline] 96027933 Identification of Streptomyces violaceoruber Tu22 genes involved in the biosynthesis of granaticin.(Mol. Gen. Genet.) [1995]
3uniprot[Pubmed] 9831526 [Medline] 99051446 The granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tu22: sequence analysis and expression in a heterologous host.(Chem. Biol.) [1998]

C9YYJ0_STRSW
(C9YYJ0)

1e-108

395

49%

Product: Putative NDP-hexose 2,3-dehydratase
Gene: SCAB_83991
Organism: Streptomyces scabies (strain 87.22)
Streptomyces scabiei

1uniprot[Pubmed] 20064060
Streptomyces scabies 87-22 contains a coronafacic acid-like biosynthetic cluster that contributes to plant-microbe interactions.(Mol. Plant Microbe Interact.) [2010]

D7B006_NOCDD
(D7B006)

(2 hsp)

1e-107

395

51%

Product: NDP-hexose 23-dehydratase
Gene: Ndas_4708
Organism: Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei

1uniprot
Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010]

Q4JHQ4_9PSEU
(Q4JHQ4)

(2 hsp)

1e-107

393

49%

Product: BusO
Gene: busO
Organism: Saccharopolyspora pogona

1uniprot[Pubmed] 16179985
Butenyl-spinosyns, a natural example of genetic engineering of antibiotic biosynthetic genes.(J. Ind. Microbiol. Biotechnol.) [2006]

Q9JN57_STRFR
(Q9JN57)

(3 hsp)

1e-106

391

50%

Product: TylCVI
Gene: tylCVI
Organism: Streptomyces fradiae
Streptomyces roseoflavus

[pubmed all]
1uniprot[Pubmed] 7984112 [Medline] 95075319 Analysis of five tylosin biosynthetic genes from the tyllBA region of the Streptomyces fradiae genome.(Mol. Microbiol.) [1994]
2uniprot[Pubmed] 10467127 [Medline] 99398833 Multiple regulatory genes in the tylosin biosynthetic cluster of Streptomyces fradiae.(Chem. Biol.) [1999]
3uniprot[Pubmed] 10658660 [Medline] 20121747 The mycarose-biosynthetic genes of Streptomyces fradiae, producer of tylosin.(Microbiology) [2000]

O50540_SACER
(O50540)

(3 hsp)

1e-106

390

47%

Product: Putative 2,3 dehydratase
Gene: EryBVI
Organism: Saccharopolyspora erythraea
Streptomyces erythraeus

1uniprot[Pubmed] 9393448 [Medline] 98055166
Analysis of seven genes from the eryAI-eryK region of the erythromycin biosynthetic gene cluster in Saccharopolyspora erythraea.(Mol. Gen. Genet.) [1997]

D7RFL3_AMYOR
(D7RFL3)

(2 hsp)

1e-106

390

50%

Product: Putative sugar 2,3-dehydratase
Gene: bexV
Organism: Amycolatopsis orientalis subsp. vinearia

1uniprot[Pubmed] 20443562
A biosynthetic pathway for BE-7585A, a 2-thiosugar-containing angucycline-type natural product.(J. Am. Chem. Soc.) [2010]

A4F7N4_SACEN
(A4F7N4)

(3 hsp)

1e-106

390

47%

Product: NDP-4-keto-6-deoxy-glucose 2,3-dehydratase
Gene: eryBVI
SACE_0717
Organism: Saccharopolyspora erythraea (strain NRRL 23338)

1uniprot[Pubmed] 17369815
Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007]

Q64Y66_BACFR
(Q64Y66)

(2 hsp)

1e-106

389

43%

Product: Putative dNDP-4-keto-6-deoxy-glucose-2,3-dehydratase
Gene: BF0809
Organism: Bacteroides fragilis

1uniprot[Pubmed] 15466707
Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation.(Proc. Natl. Acad. Sci. U.S.A.) [2004]

A8Y8H1_STRAM
(A8Y8H1)

(2 hsp)

1e-106

389

49%

Product: Probable NDP-hexose dehydratase
Gene: srm7
Organism: Streptomyces ambofaciens

1uniprot
Organization of the biosynthetic gene cluster for the macrolide antibiotic spiramycin in Streptomyces ambofaciens.(Microbiology (Mosc.)) [2007]

Q0H2W5_9ACTO
(Q0H2W5)

(2 hsp)

1e-106

389

49%

Product: Probable NDP-hexose-2,3-dehydratase
Gene: atS14
Organism: Actinomadura melliaura

1uniprot[Pubmed] 16873021
Deciphering indolocarbazole and enediyne aminodideoxypentose biosynthesis through comparative genomics: insights from the AT2433 biosynthetic locus.(Chem. Biol.) [2006]

O33941_SACER
(O33941)

(3 hsp)

1e-106

388

47%

Product: EryBVI
Gene: eryBVI
Organism: Saccharopolyspora erythraea
Streptomyces erythraeus

1uniprot[Pubmed] 9353926 [Medline] 98015410
Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production.(Microbiology)

Q0R4N9_STRAT
(Q0R4N9)

(2 hsp)

1e-102

375

48%

Product: ChlC3
Gene
Organism: Streptomyces antibioticus

1uniprot[Pubmed] 16793515
Genetic characterization of the chlorothricin gene cluster as a model for spirotetronate antibiotic biosynthesis.(Chem. Biol.) [2006]

Q53880_STRS5
(Q53880)

(2 hsp)

1e-100

371

44%

Product: Putative uncharacterized protein
Gene
Organism: Streptomyces sp. (strain C5)

1uniprot[Pubmed] 8655529 [Medline] 96236066
Cloning, sequencing, and analysis of aklaviketone reductase from Streptomyces sp. strain C5.(J. Bacteriol.) [1996]

C4XJ85_DESMR
(C4XJ85)

2e-99

367

46%

Product: NDP-hexose 2,3-dehydratase
Gene: DMR_07580
Organism: Desulfovibrio magneticus (strain ATCC 700980 / DSM 13731 / RS-1)

1uniprot[Pubmed] 19675025
Whole genome sequence of Desulfovibrio magneticus strain RS-1 revealed common gene clusters in magnetotactic bacteria.(Genome Res.) [2009]

A0M305_GRAFK
(A0M305)

(2 hsp)

1e-96

358

39%

Product: NDP-hexose 2,3-dehydratase
Gene: GFO_2035
Organism: Gramella forsetii (strain KT0803)

1uniprot[Pubmed] 17107561
Whole genome analysis of the marine Bacteroidetes'Gramella forsetii' reveals adaptations to degradation of polymeric organic matter.(Environ. Microbiol.) [2006]

Q83X51_STRRO
(Q83X51)

(2 hsp)

1e-94

352

46%

Product: Putative NDP-4-keto-6-deoxyhexose 2,3-dehydratase
Gene: lkmBVI
Organism: Streptomyces rochei
Streptomyces parvullus

[pubmed all]
1uniprot[Pubmed] 12791134 [Medline] 22676866 The large linear plasmid pSLA2-L of Streptomyces rochei has an unusually condensed gene organization for secondary metabolism.(Mol. Microbiol.) [2003]
2uniprot[Pubmed] 10954087 [Medline] 20408175 Cloning and analysis of the replication origin and the telomeres of the large linear plasmid pSLA2-L in Streptomyces rochei.(Mol. Gen. Genet.) [2000]
3uniprot[Pubmed] 10767533 [Medline] 20231737 Identification of two polyketide synthase gene clusters on the linear plasmid pSLA2-L in Streptomyces rochei.(Gene) [2000]
4uniprot[Pubmed] 9836424 [Medline] 99053144 Physical mapping of the linear plasmid pSLA2-L and localization of the eryAI and actI homologs.(Biosci. Biotechnol. Biochem.) [1998]

Q5Y9H9_9ACTO
(Q5Y9H9)

(3 hsp)

5e-88

330

42%

Product: Deoxyhexose dehydratase
Gene: eryBVI
Organism: Aeromicrobium erythreum

1uniprot[Pubmed] 15257441
The erythromycin biosynthetic gene cluster of Aeromicrobium erythreum.(J. Ind. Microbiol. Biotechnol.) [2004]

C7G1S5_STRGR
(C7G1S5)

2e-85

320

43%

Product: Putative 2,3-dehydratase
Gene
Organism: Streptomyces griseus

1uniprot
Identification of the biosynthetic gene cluster of A-500359s in Streptomyces griseus SANK60196.(J. Antibiot.) [2009]