BLAST table : Mith_00300

DB	UniProtKB

	accession	Evalue	Score	Ident.	link	product	gene	organism
1	Q194P5_STRAA (Q194P5)	0.0	758	100%	UniProt GenBank	Glycosyltransferase	mtmGI	Streptomyces argillaceus
2	Q70J80_STRGR (Q70J80)	1e-58	232	39%	UniProt GenBank	Glycosyltransferase	cmmGI	Streptomyces griseus subsp. griseus
3	Q70J68_STRGR (Q70J68)	7e-50	202	38%	UniProt GenBank	Glycosyltransferase	cmmGIV	Streptomyces griseus subsp. griseus
4	B3TMN6_9ACTO (B3TMN6)	5e-47	193	35%	UniProt GenBank	Glycosyltransferase	KijA4	Actinomadura kijaniata
5	B3TMP5_9ACTO (B3TMP5)	2e-46	191	36%	UniProt GenBank	Glycosyltransferase	KijC1	Actinomadura kijaniata
6	B5L6L8_MICCH (B5L6L8)	3e-46	190	34%	UniProt GenBank	Glycosyltransferase		Micromonospora chalcea
7	D8I4K4_AMYMU (D8I4K4)	2e-45	188	34%	UniProt GenBank	Putative glycosyl transferase	AMED_5418	Amycolatopsis mediterranei (strain U-32)
8	A4F7P3_SACEN (A4F7P3)	3e-44	184	33%	UniProt GenBank	Glycosyl transferase, NDP-D-desosamine : 3-L-mycarosyl erythronolide B	eryCIII SACE_0726	Saccharopolyspora erythraea (strain NRRL 23338)
9	O54224_SACER (O54224)	3e-44	184	33%	UniProt GenBank	Glycosyltransferase	eryCIII	Saccharopolyspora erythraea Streptomyces erythraeus
10	O33935_SACER (O33935)	3e-44	184	33%	UniProt GenBank	Desosaminyltransferase	eryCIII	Saccharopolyspora erythraea Streptomyces erythraeus
11	Q70J70_STRGR (Q70J70)	1e-43	181	39%	UniProt GenBank	Glycosyltransferase	cmmGIII	Streptomyces griseus subsp. griseus
12	B3TMP7_9ACTO (B3TMP7)	2e-43	181	32%	UniProt GenBank	Glycosyltransferase	KijC3	Actinomadura kijaniata
13	Q0R4P9_STRAT (Q0R4P9)	7e-43	179	35%	UniProt GenBank	ChlC7		Streptomyces antibioticus
14	Q93KW3_STRVR (Q93KW3)	8e-43	179	35%	UniProt GenBank	Putative glycosyltransferase	aviGT1	Streptomyces viridochromogenes
15	E5RLN7_9ACTO (E5RLN7)	1e-42	178	34%	UniProt GenBank	Putative glycosyltransferase	pnxGT2	Streptomyces sp. TA-0256
16	D8I4K0_AMYMU (D8I4K0)	2e-42	177	36%	UniProt GenBank	Putative glycosyl transferase	AMED_5414	Amycolatopsis mediterranei (strain U-32)
17	Q194P9_STRAA (Q194P9)	4e-42	177	35%	UniProt GenBank	Glycosyltransferase	mtmGIII	Streptomyces argillaceus
18	D7BZS5_STRBB (D7BZS5)	8e-42	176	34%	UniProt GenBank	IroB	SBI_06860	Streptomyces bingchenggensis (strain BCW-1)
19	B5L6L9_MICCH (B5L6L9)	3e-41	174	34%	UniProt GenBank	Glycosyltransferase		Micromonospora chalcea
20	D7BZS3_STRBB (D7BZS3)	5e-41	173	33%	UniProt GenBank	Glycosyl transferase, NDP-D-desosamine: 3-L-mycarosyl erythronolide B	SBI_06858	Streptomyces bingchenggensis (strain BCW-1)
21	Q5Y9G8_9ACTO (Q5Y9G8)	6e-41	173	33%	UniProt GenBank	L-desosaminyltransferase	eryCIII	Aeromicrobium erythreum
22	A8WDM7_9ACTO (A8WDM7)	7e-41	172	34%	UniProt GenBank	Glycosyltransferase		Streptomyces eurythermus
23	D2AY79_STRRD (D2AY79)	3e-40	171	39%	UniProt GenBank	IroB	Sros_4185	Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
24	A4GV88_9ACTO (A4GV88)	3e-40	170	34%	UniProt GenBank	Glycosyltransferase	holL	Streptomyces sp. Tu1156
25	D7B009_NOCDD (D7B009)	3e-40	170	35%	UniProt GenBank	Putative uncharacterized protein	Ndas_4711	Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488) Actinomadura dassonvillei
26	D7AZA5_NOCDD (D7AZA5)	4e-40	170	35%	UniProt GenBank	Putative uncharacterized protein	Ndas_4699	Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488) Actinomadura dassonvillei
27	Q9ZGB8_STRCY (Q9ZGB8)	5e-40	169	33%	UniProt GenBank	Glycosyl transferase homolog	lanGT1	Streptomyces cyanogenus
28	Q9ZGH7_9ACTO (Q9ZGH7)	8e-40	169	34%	UniProt GenBank	Glycosyl transferase	desVII	Streptomyces venezuelae
29	C4NYM1_9ACTO (C4NYM1)	8e-40	169	34%	UniProt GenBank	SaqGT6	saqGT6	Micromonospora sp. Tu 6368
30	Q2I780_9ACTO (Q2I780)	1e-39	168	35%	UniProt GenBank	PlaA6	plaA6 STTU_1431	Streptomyces sp. Tu6071
31	Q2P9Y9_9ACTO (Q2P9Y9)	2e-39	168	34%	UniProt GenBank	Glycosyl transferase	stfG	Streptomyces steffisburgensis
32	P95834_STRPE (P95834)	5e-39	166	33%	UniProt GenBank	Putative baumycin biosynthesis protein	dnrH	Streptomyces peucetius
33	B5L6J8_MICCH (B5L6J8)	1e-38	165	34%	UniProt GenBank	Glycosyltransferase		Micromonospora chalcea
34	Q9RPA1_STRFR (Q9RPA1)	1e-38	165	33%	UniProt GenBank	Glycosyl transferase	urdGT1b	Streptomyces fradiae Streptomyces roseoflavus
35	D7BZR5_STRBB (D7BZR5)	2e-38	165	36%	UniProt GenBank	Glycosyl transferase, NDP-D-desosamine: 3-L-mycarosyl erythronolide B	SBI_06850	Streptomyces bingchenggensis (strain BCW-1)
36	B3TMP8_9ACTO (B3TMP8)	2e-38	164	37%	UniProt GenBank	Glycosyltransferase	KijC4	Actinomadura kijaniata
37	P95747_STRFR (P95747)	3e-38	164	33%	UniProt GenBank	Glycosyltransferase	tylMII(orf2*)	Streptomyces fradiae Streptomyces roseoflavus
38	B3TMR7_9ACTO (B3TMR7)	3e-38	164	35%	UniProt GenBank	Glycosyltransferase	KijD9	Actinomadura kijaniata
39	B5G890_9ACTO (B5G890)	6e-38	163	32%	UniProt GenBank	Glycosyltransferase family 28 domain-containing protein	SSBG_00498	Streptomyces sp. SPB74
40	Q83WE1_MICGR (Q83WE1)	7e-38	162	32%	UniProt GenBank	Glycosyltransferase	mycB	Micromonospora griseorubida
41	Q9RP99_STRFR (Q9RP99)	7e-38	162	34%	UniProt GenBank	Glycosyl transferase	urdGT1c	Streptomyces fradiae Streptomyces roseoflavus
42	A1C188_9ACTO (A1C188)	8e-38	162	33%	UniProt GenBank	L-rhamnosyltransferase		Streptomyces echinatus
43	Q194Q0_STRAA (Q194Q0)	9e-38	162	34%	UniProt GenBank	Glycosyltransferase	mtmGIV	Streptomyces argillaceus
44	Q8KRX7_9ACTO (Q8KRX7)	1e-37	162	34%	UniProt GenBank	NbmD	nbmD	Streptomyces narbonensis
45	A4GV89_9ACTO (A4GV89)	1e-37	162	32%	UniProt GenBank	Glycosyltransferase	holN	Streptomyces sp. FU107
46	D1GLU2_9ACTO (D1GLU2)	2e-37	161	34%	UniProt GenBank	Glycosyltransferase	slgG	Streptomyces lydicus
47	A4GV85_9ACTO (A4GV85)	2e-37	161	33%	UniProt GenBank	Glycosyltransferase	holC	Streptomyces rufochromogenes
48	D7AZB3_NOCDD (D7AZB3)	4e-37	160	34%	UniProt GenBank	Putative uncharacterized protein	Ndas_4707	Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488) Actinomadura dassonvillei
49	C4NYL0_9ACTO (C4NYL0)	5e-37	160	32%	UniProt GenBank	SaqGT3	saqGT3	Micromonospora sp. Tu 6368
50	Q9RIP9_STRNO (Q9RIP9)	8e-37	159	34%	UniProt GenBank	SnogZ	snogZ	Streptomyces nogalater
51	D7BZR2_STRBB (D7BZR2)	1e-36	159	34%	UniProt GenBank	Glycosyl transferase, NDP-D-desosamine: 3-L-mycarosyl erythronolide B	SBI_06847	Streptomyces bingchenggensis (strain BCW-1)
52	D7BZT2_STRBB (D7BZT2)	1e-36	159	33%	UniProt GenBank	IroB	SBI_06867	Streptomyces bingchenggensis (strain BCW-1)
53	O87831_STRAT (O87831)	1e-36	159	32%	UniProt GenBank	Glycosyltransferase	oleG2	Streptomyces antibioticus
54	D6MSX4_9ACTO (D6MSX4)	1e-36	158	33%	UniProt GenBank	SsfS6	ssfS6	Streptomyces sp. SF2575
55	E8RWS3_MICSL (E8RWS3)	2e-36	158	32%	UniProt GenBank	Putative uncharacterized protein	ML5_4412	Micromonospora sp. (strain L5)
56	D9T2A9_MICAI (D9T2A9)	2e-36	157	31%	UniProt GenBank	Putative uncharacterized protein	Micau_4012	Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
57	D9T2A6_MICAI (D9T2A6)	3e-36	157	32%	UniProt GenBank	Putative uncharacterized protein	Micau_4009	Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
58	Q8GHC2_9ACTO (Q8GHC2)	3e-36	157	37%	UniProt GenBank	Glycosyltransferase	cloM	Streptomyces roseochromogenes subsp. oscitans
59	Q9F839_9ACTO (Q9F839)	3e-36	157	30%	UniProt GenBank	TDP-megosamine glycosyltransferase	megDI	Micromonospora megalomicea subsp. nigra
60	Q4R0L9_STRCX (Q4R0L9)	3e-36	157	37%	UniProt GenBank	ChaGT1 protein	chaGT1	Streptomyces chartreusis
61	D9SZA9_MICAI (D9SZA9)	3e-36	157	38%	UniProt GenBank	Putative uncharacterized protein	Micau_3719	Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
62	C4RP72_9ACTO (C4RP72)	3e-36	157	31%	UniProt GenBank	Glycosyl transferase	MCAG_03635	Micromonospora sp. ATCC 39149
63	Q9F826_9ACTO (Q9F826)	3e-36	157	31%	UniProt GenBank	TDP-desosamine glycosyltransferase	megCIII	Micromonospora megalomicea subsp. nigra
64	Q2HR28_9ACTO (Q2HR28)	8e-36	156	32%	UniProt GenBank	Putative O-glycosyltransferase	schS9	Streptomyces sp. SCC 2136
65	B5G8A2_9ACTO (B5G8A2)	8e-36	155	33%	UniProt GenBank	Glycosyltransferase family 28 domain-containing protein	SSBG_00510	Streptomyces sp. SPB74
66	Q0R4N0_STRAT (Q0R4N0)	9e-36	155	33%	UniProt GenBank	ChlC6		Streptomyces antibioticus
67	E8S036_MICSL (E8S036)	1e-35	155	38%	UniProt GenBank	Putative uncharacterized protein	ML5_4680	Micromonospora sp. (strain L5)
68	D6AXN2_9ACTO (D6AXN2)	1e-35	155	31%	UniProt GenBank	RdmH	SSHG_05324	Streptomyces albus J1074
69	Q9L9F5_STRSH (Q9L9F5)	2e-35	155	37%	UniProt GenBank	NovM	novM	Streptomyces spheroides Streptomyces caeruleus
70	D8I4I4_AMYMU (D8I4I4)	2e-35	154	33%	UniProt GenBank	Putative glycosyl transferase	AMED_5398	Amycolatopsis mediterranei (strain U-32)
71	D5UX47_TSUPD (D5UX47)	4e-35	153	33%	UniProt GenBank	Putative uncharacterized protein	Tpau_3487	Tsukamurella paurometabola (strain ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040) Corynebacterium paurometabolum
72	D8I4J6_AMYMU (D8I4J6)	4e-35	153	35%	UniProt GenBank	Putative glycosyl transferase	AMED_5410	Amycolatopsis mediterranei (strain U-32)
73	Q4JHR2_9PSEU (Q4JHR2)	4e-35	153	31%	UniProt GenBank	BusG	busG	Saccharopolyspora pogona
74	Q53881_STRS5 (Q53881)	5e-35	153	32%	UniProt GenBank	Glycosyltransferase	dauH	Streptomyces sp. (strain C5)
75	Q4JHQ3_9PSEU (Q4JHQ3)	6e-35	153	31%	UniProt GenBank	BusP	busP	Saccharopolyspora pogona
76	Q8VWB7_9ACTO (Q8VWB7)	6e-35	153	30%	UniProt GenBank	AclK	aclK	Streptomyces galilaeus
77	D7B025_NOCDD (D7B025)	7e-35	153	33%	UniProt GenBank	Putative uncharacterized protein	Ndas_4727	Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488) Actinomadura dassonvillei
78	E8RWS0_MICSL (E8RWS0)	9e-35	152	31%	UniProt GenBank	Putative uncharacterized protein	ML5_4409	Micromonospora sp. (strain L5)
79	Q9F832_9ACTO (Q9F832)	9e-35	152	32%	UniProt GenBank	TDP-mycarose glycosyltransferase	megBV	Micromonospora megalomicea subsp. nigra
80	E0KQM6_STRVO (E0KQM6)	1e-34	152	31%	UniProt GenBank	Putative uncharacterized protein	StrviDRAFT_4953	Streptomyces violaceusniger Tu 4113
81	Q83X73_STRRO (Q83X73)	2e-34	151	30%	UniProt GenBank	Glycosyltransferase LkmI	lkmI	Streptomyces rochei Streptomyces parvullus
82	D8I4J7_AMYMU (D8I4J7)	2e-34	151	34%	UniProt GenBank	Putative glycosyl transferase	AMED_5411	Amycolatopsis mediterranei (strain U-32)
83	A4F7N6_SACEN (A4F7N6)	2e-34	151	30%	UniProt GenBank	6-DEB TDP-mycarosyl glycosyltransferase	eryBV SACE_0719	Saccharopolyspora erythraea (strain NRRL 23338)
84	O33939_SACER (O33939)	2e-34	151	30%	UniProt GenBank	EryBV Putative glycosyltransferase	eryBV EryBV	Saccharopolyspora erythraea Streptomyces erythraeus
85	D8I4J9_AMYMU (D8I4J9)	2e-34	151	35%	UniProt GenBank	Putative glycosyl transferase	AMED_5413	Amycolatopsis mediterranei (strain U-32)
86	Q6QR18_STRGL (Q6QR18)	2e-34	151	32%	UniProt GenBank	Glycosyl transferase		Streptomyces globisporus
87	D7B014_NOCDD (D7B014)	3e-34	150	33%	UniProt GenBank	Putative uncharacterized protein	Ndas_4716	Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488) Actinomadura dassonvillei
88	Q9L4U6_9ACTO (Q9L4U6)	4e-34	150	33%	UniProt GenBank	Putative glycosyl transferase	aknS	Streptomyces galilaeus
89	Q9ALN7_9PSEU (Q9ALN7)	5e-34	150	29%	UniProt GenBank	Probable NDP-forosamyltransferase	spnP	Saccharopolyspora spinosa
90	D7AZA6_NOCDD (D7AZA6)	6e-34	149	32%	UniProt GenBank	Putative uncharacterized protein	Ndas_4700	Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488) Actinomadura dassonvillei
91	E8RWU6_MICSL (E8RWU6)	8e-34	149	34%	UniProt GenBank	Putative uncharacterized protein	ML5_4435	Micromonospora sp. (strain L5)
92	D9T283_MICAI (D9T283)	8e-34	149	34%	UniProt GenBank	Putative uncharacterized protein	Micau_3986	Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
93	Q9RN63_STRNO (Q9RN63)	1e-33	149	33%	UniProt GenBank	Putative glycosyl transferase	snogE	Streptomyces nogalater
94	D7B013_NOCDD (D7B013)	1e-33	149	32%	UniProt GenBank	Putative uncharacterized protein	Ndas_4715	Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488) Actinomadura dassonvillei
95	E4N0M1_KITSK (E4N0M1)	2e-33	148	36%	UniProt GenBank	Putative glycosyltransferase	KSE_59350	Kitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054) Streptomyces setae
96	Q0H2X6_9ACTO (Q0H2X6)	2e-33	147	32%	UniProt GenBank	Putative O-glycosyltransferase	atG1	Actinomadura melliaura
97	Q9L555_9ACTO (Q9L555)	4e-33	147	29%	UniProt GenBank	AknK	aknK	Streptomyces galilaeus
98	A4FFB3_SACEN (A4FFB3)	4e-33	147	34%	UniProt GenBank	Putative uncharacterized protein	SACE_3464	Saccharopolyspora erythraea (strain NRRL 23338)
99	Q5SFB5_STRBI (Q5SFB5)	5e-33	147	28%	UniProt GenBank	Putative chalcose glycosyltransferase	chmCIII	Streptomyces bikiniensis
100	Q9ALM8_9PSEU (Q9ALM8)	5e-33	146	30%	UniProt GenBank	Probable NDP-rhamnosyltransferase	spnG	Saccharopolyspora spinosa

accession

alignment

Evalue

Score

Ident.

link

information

pubmed

Q194P5_STRAA
(Q194P5)

0.0

758

100%

Product: Glycosyltransferase
Gene: mtmGI
Organism: Streptomyces argillaceus

[pubmed all]
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]

B3TMN6_9ACTO
(B3TMN6)

5e-47

193

35%

Product: Glycosyltransferase
Gene: KijA4
Organism: Actinomadura kijaniata

1uniprot[Pubmed] 17985890
Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007]

B3TMP5_9ACTO
(B3TMP5)

2e-46

191

36%

Product: Glycosyltransferase
Gene: KijC1
Organism: Actinomadura kijaniata

1uniprot[Pubmed] 17985890
Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007]

B5L6L8_MICCH
(B5L6L8)

3e-46

190

34%

Product: Glycosyltransferase
Gene
Organism: Micromonospora chalcea

1uniprot[Pubmed] 18586939
Cloning and characterization of the tetrocarcin A gene cluster from Micromonospora chalcea NRRL 11289 reveals a highly conserved strategy for tetronate biosynthesis in spirotetronate antibiotics.(J. Bacteriol.) [2008]

D8I4K4_AMYMU
(D8I4K4)

2e-45

188

34%

Product: Putative glycosyl transferase
Gene: AMED_5418
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

A4F7P3_SACEN
(A4F7P3)

3e-44

184

33%

Product: Glycosyl transferase, NDP-D-desosamine : 3-L-mycarosyl erythronolide B
Gene: eryCIII
SACE_0726
Organism: Saccharopolyspora erythraea (strain NRRL 23338)

1uniprot[Pubmed] 17369815
Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007]

O33935_SACER
(O33935)

3e-44

184

33%

Product: Desosaminyltransferase
Gene: eryCIII
Organism: Saccharopolyspora erythraea
Streptomyces erythraeus

1uniprot[Pubmed] 9353926 [Medline] 98015410
Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production.(Microbiology)

B3TMP7_9ACTO
(B3TMP7)

2e-43

181

32%

Product: Glycosyltransferase
Gene: KijC3
Organism: Actinomadura kijaniata

1uniprot[Pubmed] 17985890
Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007]

Q0R4P9_STRAT
(Q0R4P9)

7e-43

179

35%

Product: ChlC7
Gene
Organism: Streptomyces antibioticus

1uniprot[Pubmed] 16793515
Genetic characterization of the chlorothricin gene cluster as a model for spirotetronate antibiotic biosynthesis.(Chem. Biol.) [2006]

Q93KW3_STRVR
(Q93KW3)

8e-43

179

35%

Product: Putative glycosyltransferase
Gene: aviGT1
Organism: Streptomyces viridochromogenes

[pubmed all]
1uniprot[Pubmed] 11410376 [Medline] 21303144 Biosynthesis of the orthosomycin antibiotic avilamycin A: deductions from the molecular analysis of the avi biosynthetic gene cluster of Streptomyces viridochromogenes Tu57 and production of new antibiotics.(Chem. Biol.) [2001]
2uniprot[Pubmed] 15489167 Novel avilamycin derivatives with improved polarity generated by targeted gene disruption.(Chem. Biol.) [2004]

D8I4K0_AMYMU
(D8I4K0)

2e-42

177

36%

Product: Putative glycosyl transferase
Gene: AMED_5414
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

Q194P9_STRAA
(Q194P9)

4e-42

177

35%

Product: Glycosyltransferase
Gene: mtmGIII
Organism: Streptomyces argillaceus

[pubmed all]
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]

D7BZS5_STRBB
(D7BZS5)

8e-42

176

34%

Product: IroB
Gene: SBI_06860
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

B5L6L9_MICCH
(B5L6L9)

3e-41

174

34%

Product: Glycosyltransferase
Gene
Organism: Micromonospora chalcea

D7BZS3_STRBB
(D7BZS3)

5e-41

173

33%

Product: Glycosyl transferase, NDP-D-desosamine: 3-L-mycarosyl erythronolide B
Gene: SBI_06858
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

Q5Y9G8_9ACTO
(Q5Y9G8)

6e-41

173

33%

Product: L-desosaminyltransferase
Gene: eryCIII
Organism: Aeromicrobium erythreum

1uniprot[Pubmed] 15257441
The erythromycin biosynthetic gene cluster of Aeromicrobium erythreum.(J. Ind. Microbiol. Biotechnol.) [2004]

D2AY79_STRRD
(D2AY79)

3e-40

171

39%

Product: IroB
Gene: Sros_4185
Organism: Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)

1uniprot
Complete genome sequence of Streptosporangium roseum type strain (NI 9100T).(Stand. Genomic Sci.) [2010]

A4GV88_9ACTO
(A4GV88)

3e-40

170

34%

Product: Glycosyltransferase
Gene: holL
Organism: Streptomyces sp. Tu1156

1uniprot[Pubmed] 17497146
A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]

D7B009_NOCDD
(D7B009)

3e-40

170

35%

Product: Putative uncharacterized protein
Gene: Ndas_4711
Organism: Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei

1uniprot
Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010]

D7AZA5_NOCDD
(D7AZA5)

4e-40

170

35%

Product: Putative uncharacterized protein
Gene: Ndas_4699
Organism: Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei

1uniprot
Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010]

Q9ZGB8_STRCY
(Q9ZGB8)

5e-40

169

33%

Product: Glycosyl transferase homolog
Gene: lanGT1
Organism: Streptomyces cyanogenus

1uniprot[Pubmed] 9933932 [Medline] 99132695
Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin biosynthesis.(FEMS Microbiol. Lett.) [1999]

Q9ZGH7_9ACTO
(Q9ZGH7)

8e-40

169

34%

Product: Glycosyl transferase
Gene: desVII
Organism: Streptomyces venezuelae

1uniprot[Pubmed] 9770448 [Medline] 98445333
A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity.(Proc. Natl. Acad. Sci. U.S.A.) [1998]

C4NYM1_9ACTO
(C4NYM1)

8e-40

169

34%

Product: SaqGT6
Gene: saqGT6
Organism: Micromonospora sp. Tu 6368

[pubmed all]
1uniprot[Pubmed] 17497146 A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]
2uniprot[Pubmed] 19384899 Cloning and sequencing of the biosynthetic gene cluster for saquayamycin z and galtamycin B and the elucidation of the assembly of their saccharide chains.(Chembiochem) [2009]

Q2I780_9ACTO
(Q2I780)

1e-39

168

35%

Product: PlaA6
Gene: plaA6
STTU_1431
Organism: Streptomyces sp. Tu6071

1uniprot[Pubmed] 16632249
Biosynthesis of the terpene phenalinolactone in Streptomyces sp. Tu6071: analysis of the gene cluster and generation of derivatives.(Chem. Biol.) [2006]

Q2P9Y9_9ACTO
(Q2P9Y9)

2e-39

168

34%

Product: Glycosyl transferase
Gene: stfG
Organism: Streptomyces steffisburgensis

1uniprot[Pubmed] 16751529
Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin.(Appl. Environ. Microbiol.) [2006]

P95834_STRPE
(P95834)

5e-39

166

33%

Product: Putative baumycin biosynthesis protein
Gene: dnrH
Organism: Streptomyces peucetius

[pubmed all]
1uniprot[Pubmed] 8955419 [Medline] 97113559 Enhanced antibiotic production by manipulation of the Streptomyces peucetius dnrH and dnmT genes involved in doxorubicin (adriamycin) biosynthesis.(J. Bacteriol.) [1996]
2uniprot[Pubmed] 9864344 [Medline] 99084971 Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene.(J. Bacteriol.) [1999]

B5L6J8_MICCH
(B5L6J8)

1e-38

165

34%

Product: Glycosyltransferase
Gene
Organism: Micromonospora chalcea

Q9RPA1_STRFR
(Q9RPA1)

1e-38

165

33%

Product: Glycosyl transferase
Gene: urdGT1b
Organism: Streptomyces fradiae
Streptomyces roseoflavus

1uniprot[Pubmed] 10658661 [Medline] 20121748
Two new tailoring enzymes, a glycosyltransferase and an oxygenase, involved in biosynthesis of the angucycline antibiotic urdamycin A in Streptomyces fradiae Tu2717.(Microbiology) [2000]

D7BZR5_STRBB
(D7BZR5)

2e-38

165

36%

Product: Glycosyl transferase, NDP-D-desosamine: 3-L-mycarosyl erythronolide B
Gene: SBI_06850
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

B3TMP8_9ACTO
(B3TMP8)

2e-38

164

37%

Product: Glycosyltransferase
Gene: KijC4
Organism: Actinomadura kijaniata

1uniprot[Pubmed] 17985890
Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007]

P95747_STRFR
(P95747)

3e-38

164

33%

Product: Glycosyltransferase
Gene: tylMII(orf2*)
Organism: Streptomyces fradiae
Streptomyces roseoflavus

1uniprot[Pubmed] 9031628 [Medline] 97183662
Analysis of four tylosin biosynthetic genes from the tylLM region of Streptomyces fradiae.(Gene) [1997]

B3TMR7_9ACTO
(B3TMR7)

3e-38

164

35%

Product: Glycosyltransferase
Gene: KijD9
Organism: Actinomadura kijaniata

1uniprot[Pubmed] 17985890
Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007]

Q83WE1_MICGR
(Q83WE1)

7e-38

162

32%

Product: Glycosyltransferase
Gene: mycB
Organism: Micromonospora griseorubida

1uniprot[Pubmed] 12583909 [Medline] 22472038
Organization of the biosynthetic gene cluster for the polyketide macrolide mycinamicin in Micromonospora griseorubida.(FEMS Microbiol. Lett.) [2003]

Q9RP99_STRFR
(Q9RP99)

7e-38

162

34%

Product: Glycosyl transferase
Gene: urdGT1c
Organism: Streptomyces fradiae
Streptomyces roseoflavus

Q194Q0_STRAA
(Q194Q0)

9e-38

162

34%

Product: Glycosyltransferase
Gene: mtmGIV
Organism: Streptomyces argillaceus

[pubmed all]
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]

A4GV89_9ACTO
(A4GV89)

1e-37

162

32%

Product: Glycosyltransferase
Gene: holN
Organism: Streptomyces sp. FU107

1uniprot[Pubmed] 17497146
A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]

D1GLU2_9ACTO
(D1GLU2)

2e-37

161

34%

Product: Glycosyltransferase
Gene: slgG
Organism: Streptomyces lydicus

1uniprot
Deciphering biosynthesis of the RNA polymerase inhibitor streptolydigin and generation of glycosylated derivatives.(Chem. Biol.) [2009]

A4GV85_9ACTO
(A4GV85)

2e-37

161

33%

Product: Glycosyltransferase
Gene: holC
Organism: Streptomyces rufochromogenes

1uniprot[Pubmed] 17497146
A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]

D7AZB3_NOCDD
(D7AZB3)

4e-37

160

34%

Product: Putative uncharacterized protein
Gene: Ndas_4707
Organism: Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei

1uniprot
Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010]

C4NYL0_9ACTO
(C4NYL0)

5e-37

160

32%

Product: SaqGT3
Gene: saqGT3
Organism: Micromonospora sp. Tu 6368

[pubmed all]
1uniprot[Pubmed] 17497146 A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]
2uniprot[Pubmed] 19384899 Cloning and sequencing of the biosynthetic gene cluster for saquayamycin z and galtamycin B and the elucidation of the assembly of their saccharide chains.(Chembiochem) [2009]

Q9RIP9_STRNO
(Q9RIP9)

8e-37

159

34%

Product: SnogZ
Gene: snogZ
Organism: Streptomyces nogalater

[pubmed all]
1uniprot[Pubmed] 8668120 [Medline] 96242142 A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.(Mol. Gen. Genet.) [1996]
2uniprot[Pubmed] 9349712 [Medline] 98007868 Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.(Mol. Gen. Genet.) [1997]
3uniprot[Pubmed] 8760909 [Medline] 96349102 Production of hybrid anthracycline antibiotics by heterologous expression of Streptomyces nogalater nogalamycin biosynthesis genes.(Microbiology) [1996]

D7BZR2_STRBB
(D7BZR2)

1e-36

159

34%

Product: Glycosyl transferase, NDP-D-desosamine: 3-L-mycarosyl erythronolide B
Gene: SBI_06847
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

D7BZT2_STRBB
(D7BZT2)

1e-36

159

33%

Product: IroB
Gene: SBI_06867
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

O87831_STRAT
(O87831)

1e-36

159

32%

Product: Glycosyltransferase
Gene: oleG2
Organism: Streptomyces antibioticus

1uniprot[Pubmed] 9749673 [Medline] 98420102
Analysis of a Streptomyces antibioticus chromosomal region involved in oleandomycin biosynthesis, which encodes two glycosyltransferases responsible for glycosylation of the macrolactone ring.(Mol. Gen. Genet.) [1998]

D6MSX4_9ACTO
(D6MSX4)

1e-36

158

33%

Product: SsfS6
Gene: ssfS6
Organism: Streptomyces sp. SF2575

1uniprot[Pubmed] 19908837
Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.(J. Am. Chem. Soc.) [2009]

Q8GHC2_9ACTO
(Q8GHC2)

3e-36

157

37%

Product: Glycosyltransferase
Gene: cloM
Organism: Streptomyces roseochromogenes subsp. oscitans

1uniprot[Pubmed] 12480894 [Medline] 22368916
Molecular cloning and sequence analysis of the clorobiocin biosynthetic gene cluster: new insights into the biosynthesis of aminocoumarin antibiotics.(Microbiology) [2002]

Q9F839_9ACTO
(Q9F839)

3e-36

157

30%

Product: TDP-megosamine glycosyltransferase
Gene: megDI
Organism: Micromonospora megalomicea subsp. nigra

1uniprot[Pubmed] 10972798 [Medline] 20430101
Biosynthesis of the anti-parasitic agent megalomicin: transformation of erythromycin to megalomicin in Saccharopolyspora erythraea.(Mol. Microbiol.) [2000]

Q4R0L9_STRCX
(Q4R0L9)

3e-36

157

37%

Product: ChaGT1 protein
Gene: chaGT1
Organism: Streptomyces chartreusis

1uniprot[Pubmed] 15911378
Biosynthesis of the antitumor agent chartreusin involves the oxidative rearrangement of an anthracyclic polyketide.(Chem. Biol.) [2005]

Q9F826_9ACTO
(Q9F826)

3e-36

157

31%

Product: TDP-desosamine glycosyltransferase
Gene: megCIII
Organism: Micromonospora megalomicea subsp. nigra

Q2HR28_9ACTO
(Q2HR28)

8e-36

156

32%

Product: Putative O-glycosyltransferase
Gene: schS9
Organism: Streptomyces sp. SCC 2136

1uniprot
Angucyclines Sch 47554 and Sch 47555 from Streptomyces sp. SCC-2136: Cloning, Sequencing, and Characterization.(Mol. Cells) [2006]

2uniprot
Molecular cloning and characterization of biosynthetic genes cluster of Sch 47554 from Streptomyces sp. SCC 2136. [2004]

Q0R4N0_STRAT
(Q0R4N0)

9e-36

155

33%

Product: ChlC6
Gene
Organism: Streptomyces antibioticus

1uniprot[Pubmed] 16793515
Genetic characterization of the chlorothricin gene cluster as a model for spirotetronate antibiotic biosynthesis.(Chem. Biol.) [2006]

Q9L9F5_STRSH
(Q9L9F5)

2e-35

155

37%

Product: NovM
Gene: novM
Organism: Streptomyces spheroides
Streptomyces caeruleus

1uniprot[Pubmed] 10770754 [Medline] 20233587
Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891.(Antimicrob. Agents Chemother.) [2000]

D8I4I4_AMYMU
(D8I4I4)

2e-35

154

33%

Product: Putative glycosyl transferase
Gene: AMED_5398
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

D8I4J6_AMYMU
(D8I4J6)

4e-35

153

35%

Product: Putative glycosyl transferase
Gene: AMED_5410
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

Q4JHR2_9PSEU
(Q4JHR2)

4e-35

153

31%

Product: BusG
Gene: busG
Organism: Saccharopolyspora pogona

1uniprot[Pubmed] 16179985
Butenyl-spinosyns, a natural example of genetic engineering of antibiotic biosynthetic genes.(J. Ind. Microbiol. Biotechnol.) [2006]

Q53881_STRS5
(Q53881)

5e-35

153

32%

Product: Glycosyltransferase
Gene: dauH
Organism: Streptomyces sp. (strain C5)

1uniprot[Pubmed] 8655529 [Medline] 96236066
Cloning, sequencing, and analysis of aklaviketone reductase from Streptomyces sp. strain C5.(J. Bacteriol.) [1996]

Q4JHQ3_9PSEU
(Q4JHQ3)

6e-35

153

31%

Product: BusP
Gene: busP
Organism: Saccharopolyspora pogona

1uniprot[Pubmed] 16179985
Butenyl-spinosyns, a natural example of genetic engineering of antibiotic biosynthetic genes.(J. Ind. Microbiol. Biotechnol.) [2006]

Q8VWB7_9ACTO
(Q8VWB7)

6e-35

153

30%

Product: AclK
Gene: aclK
Organism: Streptomyces galilaeus

1uniprot[Pubmed] 12399480 [Medline] 22286521
Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus.(J. Bacteriol.) [2002]

D7B025_NOCDD
(D7B025)

7e-35

153

33%

Product: Putative uncharacterized protein
Gene: Ndas_4727
Organism: Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei

1uniprot
Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010]

Q9F832_9ACTO
(Q9F832)

9e-35

152

32%

Product: TDP-mycarose glycosyltransferase
Gene: megBV
Organism: Micromonospora megalomicea subsp. nigra

Q83X73_STRRO
(Q83X73)

2e-34

151

30%

Product: Glycosyltransferase LkmI
Gene: lkmI
Organism: Streptomyces rochei
Streptomyces parvullus

[pubmed all]
1uniprot[Pubmed] 12791134 [Medline] 22676866 The large linear plasmid pSLA2-L of Streptomyces rochei has an unusually condensed gene organization for secondary metabolism.(Mol. Microbiol.) [2003]
2uniprot[Pubmed] 10954087 [Medline] 20408175 Cloning and analysis of the replication origin and the telomeres of the large linear plasmid pSLA2-L in Streptomyces rochei.(Mol. Gen. Genet.) [2000]
3uniprot[Pubmed] 10767533 [Medline] 20231737 Identification of two polyketide synthase gene clusters on the linear plasmid pSLA2-L in Streptomyces rochei.(Gene) [2000]
4uniprot[Pubmed] 9836424 [Medline] 99053144 Physical mapping of the linear plasmid pSLA2-L and localization of the eryAI and actI homologs.(Biosci. Biotechnol. Biochem.) [1998]

D8I4J7_AMYMU
(D8I4J7)

2e-34

151

34%

Product: Putative glycosyl transferase
Gene: AMED_5411
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

A4F7N6_SACEN
(A4F7N6)

2e-34

151

30%

Product: 6-DEB TDP-mycarosyl glycosyltransferase
Gene: eryBV
SACE_0719
Organism: Saccharopolyspora erythraea (strain NRRL 23338)

1uniprot[Pubmed] 17369815
Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007]

O33939_SACER
(O33939)

2e-34

151

30%

Product: EryBV
Putative glycosyltransferase
Gene: eryBV
EryBV
Organism: Saccharopolyspora erythraea
Streptomyces erythraeus

[pubmed all]
1uniprot[Pubmed] 9353926 [Medline] 98015410 Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production.(Microbiology)
2uniprot[Pubmed] 9393448 [Medline] 98055166 Analysis of seven genes from the eryAI-eryK region of the erythromycin biosynthetic gene cluster in Saccharopolyspora erythraea.(Mol. Gen. Genet.) [1997]

D8I4J9_AMYMU
(D8I4J9)

2e-34

151

35%

Product: Putative glycosyl transferase
Gene: AMED_5413
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

Q6QR18_STRGL
(Q6QR18)

2e-34

151

32%

Product: Glycosyl transferase
Gene
Organism: Streptomyces globisporus

1uniprot[Pubmed] 15123249
Generation of new landomycins by combinatorial biosynthetic manipulation of the LndGT4 gene of the landomycin E cluster in S. globisporus.(Chem. Biol.) [2004]

D7B014_NOCDD
(D7B014)

3e-34

150

33%

Product: Putative uncharacterized protein
Gene: Ndas_4716
Organism: Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei

1uniprot
Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010]

Q9L4U6_9ACTO
(Q9L4U6)

4e-34

150

33%

Product: Putative glycosyl transferase
Gene: aknS
Organism: Streptomyces galilaeus

1uniprot[Pubmed] 11016846 [Medline] 20469061
A gene cluster from Streptomyces galilaeus involved in glycosylation of aclarubicin.(Mol. Gen. Genet.) [2000]

Q9ALN7_9PSEU
(Q9ALN7)

5e-34

150

29%

Product: Probable NDP-forosamyltransferase
Gene: spnP
Organism: Saccharopolyspora spinosa

1uniprot[Pubmed] 11358695 [Medline] 21257765
Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa.(Chem. Biol.) [2001]

D7AZA6_NOCDD
(D7AZA6)

6e-34

149

32%

Product: Putative uncharacterized protein
Gene: Ndas_4700
Organism: Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei

1uniprot
Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010]

Q9RN63_STRNO
(Q9RN63)

1e-33

149

33%

Product: Putative glycosyl transferase
Gene: snogE
Organism: Streptomyces nogalater

[pubmed all]
1uniprot[Pubmed] 9349712 [Medline] 98007868 Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.(Mol. Gen. Genet.) [1997]
2uniprot[Pubmed] 10639368 [Medline] 20106987 Identification of a cyclase gene dictating the C-9 stereochemistry of anthracyclines from Streptomyces nogalater.(Antimicrob. Agents Chemother.) [2000]

D7B013_NOCDD
(D7B013)

1e-33

149

32%

Product: Putative uncharacterized protein
Gene: Ndas_4715
Organism: Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei

1uniprot
Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010]

E4N0M1_KITSK
(E4N0M1)

2e-33

148

36%

Product: Putative glycosyltransferase
Gene: KSE_59350
Organism: Kitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054)
Streptomyces setae

1uniprot[Pubmed] 21059706
Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary snapshot of the family Streptomycetaceae.(DNA Res.) [2010]

Q0H2X6_9ACTO
(Q0H2X6)

2e-33

147

32%

Product: Putative O-glycosyltransferase
Gene: atG1
Organism: Actinomadura melliaura

1uniprot[Pubmed] 16873021
Deciphering indolocarbazole and enediyne aminodideoxypentose biosynthesis through comparative genomics: insights from the AT2433 biosynthetic locus.(Chem. Biol.) [2006]

Q9L555_9ACTO
(Q9L555)

4e-33

147

29%

Product: AknK
Gene: aknK
Organism: Streptomyces galilaeus

1uniprot[Pubmed] 12137949 [Medline] 22133312
Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster.(Gene) [2002]

A4FFB3_SACEN
(A4FFB3)

4e-33

147

34%

Product: Putative uncharacterized protein
Gene: SACE_3464
Organism: Saccharopolyspora erythraea (strain NRRL 23338)

1uniprot[Pubmed] 17369815
Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007]

Q5SFB5_STRBI
(Q5SFB5)

5e-33

147

28%

Product: Putative chalcose glycosyltransferase
Gene: chmCIII
Organism: Streptomyces bikiniensis

1uniprot[Pubmed] 15561847
Chalcomycin biosynthesis gene cluster from Streptomyces bikiniensis: novel features of an unusual ketolide produced through expression of the chm polyketide synthase in Streptomyces fradiae.(Antimicrob. Agents Chemother.) [2004]

100

Q9ALM8_9PSEU
(Q9ALM8)

5e-33

146

30%

Product: Probable NDP-rhamnosyltransferase
Gene: spnG
Organism: Saccharopolyspora spinosa

1uniprot[Pubmed] 11358695 [Medline] 21257765
Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa.(Chem. Biol.) [2001]