BLAST table : Mith_00250

DB	UniProtKB

	accession	Evalue	Score	Ident.	link	product	gene	organism
1	Q194Q0_STRAA (Q194Q0)	0.0	805	100%	UniProt GenBank	Glycosyltransferase	mtmGIV	Streptomyces argillaceus
2	Q70J68_STRGR (Q70J68)	1e-106	390	52%	UniProt GenBank	Glycosyltransferase	cmmGIV	Streptomyces griseus subsp. griseus
3	D7BZR5_STRBB (D7BZR5)	2e-78	297	44%	UniProt GenBank	Glycosyl transferase, NDP-D-desosamine: 3-L-mycarosyl erythronolide B	SBI_06850	Streptomyces bingchenggensis (strain BCW-1)
4	C0JWA3_9ACTO (C0JWA3)	2e-64	251	42%	UniProt GenBank	PokGT1	pokGT1	Streptomyces diastatochromogenes
5	D8I4K4_AMYMU (D8I4K4)	5e-63	246	41%	UniProt GenBank	Putative glycosyl transferase	AMED_5418	Amycolatopsis mediterranei (strain U-32)
6	Q70J70_STRGR (Q70J70)	1e-55	221	41%	UniProt GenBank	Glycosyltransferase	cmmGIII	Streptomyces griseus subsp. griseus
7	D8I4I4_AMYMU (D8I4I4)	8e-51	206	38%	UniProt GenBank	Putative glycosyl transferase	AMED_5398	Amycolatopsis mediterranei (strain U-32)
8	Q0R4P9_STRAT (Q0R4P9)	9e-51	206	38%	UniProt GenBank	ChlC7		Streptomyces antibioticus
9	B3TMN6_9ACTO (B3TMN6)	1e-50	205	38%	UniProt GenBank	Glycosyltransferase	KijA4	Actinomadura kijaniata
10	Q194P9_STRAA (Q194P9)	1e-49	202	37%	UniProt GenBank	Glycosyltransferase	mtmGIII	Streptomyces argillaceus
11	Q935Z8_9ACTO (Q935Z8)	2e-49	201	36%	UniProt GenBank	RdmH	rdmH	Streptomyces purpurascens
12	B3TMP5_9ACTO (B3TMP5)	1e-48	199	38%	UniProt GenBank	Glycosyltransferase	KijC1	Actinomadura kijaniata
13	A4F7P3_SACEN (A4F7P3)	1e-48	198	34%	UniProt GenBank	Glycosyl transferase, NDP-D-desosamine : 3-L-mycarosyl erythronolide B	eryCIII SACE_0726	Saccharopolyspora erythraea (strain NRRL 23338)
14	O54224_SACER (O54224)	1e-48	198	34%	UniProt GenBank	Glycosyltransferase	eryCIII	Saccharopolyspora erythraea Streptomyces erythraeus
15	D8I4K0_AMYMU (D8I4K0)	3e-48	197	36%	UniProt GenBank	Putative glycosyl transferase	AMED_5414	Amycolatopsis mediterranei (strain U-32)
16	Q9ZGH7_9ACTO (Q9ZGH7)	5e-48	196	36%	UniProt GenBank	Glycosyl transferase	desVII	Streptomyces venezuelae
17	O33935_SACER (O33935)	3e-47	194	34%	UniProt GenBank	Desosaminyltransferase	eryCIII	Saccharopolyspora erythraea Streptomyces erythraeus
18	B3TMP7_9ACTO (B3TMP7)	9e-47	192	35%	UniProt GenBank	Glycosyltransferase	KijC3	Actinomadura kijaniata
19	O87831_STRAT (O87831)	1e-46	192	35%	UniProt GenBank	Glycosyltransferase	oleG2	Streptomyces antibioticus
20	D2AY79_STRRD (D2AY79)	2e-46	191	42%	UniProt GenBank	IroB	Sros_4185	Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
21	Q70J80_STRGR (Q70J80)	2e-46	191	37%	UniProt GenBank	Glycosyltransferase	cmmGI	Streptomyces griseus subsp. griseus
22	B5L6L8_MICCH (B5L6L8)	4e-46	190	34%	UniProt GenBank	Glycosyltransferase		Micromonospora chalcea
23	Q4JHQ3_9PSEU (Q4JHQ3)	7e-46	189	35%	UniProt GenBank	BusP	busP	Saccharopolyspora pogona
24	Q8KRX7_9ACTO (Q8KRX7)	9e-46	189	35%	UniProt GenBank	NbmD	nbmD	Streptomyces narbonensis
25	Q76KZ6_STRHA (Q76KZ6)	1e-45	189	34%	UniProt GenBank	Glycosyltransferase	vinC	Streptomyces halstedii
26	D6AXN2_9ACTO (D6AXN2)	3e-45	187	33%	UniProt GenBank	RdmH	SSHG_05324	Streptomyces albus J1074
27	Q9ALN7_9PSEU (Q9ALN7)	4e-45	187	34%	UniProt GenBank	Probable NDP-forosamyltransferase	spnP	Saccharopolyspora spinosa
28	Q9F839_9ACTO (Q9F839)	5e-45	186	32%	UniProt GenBank	TDP-megosamine glycosyltransferase	megDI	Micromonospora megalomicea subsp. nigra
29	D7B014_NOCDD (D7B014)	5e-45	186	33%	UniProt GenBank	Putative uncharacterized protein	Ndas_4716	Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488) Actinomadura dassonvillei
30	B5G890_9ACTO (B5G890)	1e-44	185	33%	UniProt GenBank	Glycosyltransferase family 28 domain-containing protein	SSBG_00498	Streptomyces sp. SPB74
31	A4GV89_9ACTO (A4GV89)	1e-44	185	36%	UniProt GenBank	Glycosyltransferase	holN	Streptomyces sp. FU107
32	Q0R4N0_STRAT (Q0R4N0)	2e-44	184	35%	UniProt GenBank	ChlC6		Streptomyces antibioticus
33	D7BZS3_STRBB (D7BZS3)	3e-44	184	34%	UniProt GenBank	Glycosyl transferase, NDP-D-desosamine: 3-L-mycarosyl erythronolide B	SBI_06858	Streptomyces bingchenggensis (strain BCW-1)
34	A8WDM7_9ACTO (A8WDM7)	9e-44	182	34%	UniProt GenBank	Glycosyltransferase		Streptomyces eurythermus
35	D8I4J6_AMYMU (D8I4J6)	2e-43	181	38%	UniProt GenBank	Putative glycosyl transferase	AMED_5410	Amycolatopsis mediterranei (strain U-32)
36	E5RLN7_9ACTO (E5RLN7)	2e-43	181	35%	UniProt GenBank	Putative glycosyltransferase	pnxGT2	Streptomyces sp. TA-0256
37	C4NYM1_9ACTO (C4NYM1)	3e-43	181	37%	UniProt GenBank	SaqGT6	saqGT6	Micromonospora sp. Tu 6368
38	Q83WE1_MICGR (Q83WE1)	3e-43	181	34%	UniProt GenBank	Glycosyltransferase	mycB	Micromonospora griseorubida
39	Q2P9Y9_9ACTO (Q2P9Y9)	3e-43	180	36%	UniProt GenBank	Glycosyl transferase	stfG	Streptomyces steffisburgensis
40	D7BZT2_STRBB (D7BZT2)	4e-43	180	37%	UniProt GenBank	IroB	SBI_06867	Streptomyces bingchenggensis (strain BCW-1)
41	P95834_STRPE (P95834)	5e-43	180	35%	UniProt GenBank	Putative baumycin biosynthesis protein	dnrH	Streptomyces peucetius
42	Q5Y9G8_9ACTO (Q5Y9G8)	6e-43	179	34%	UniProt GenBank	L-desosaminyltransferase	eryCIII	Aeromicrobium erythreum
43	D9VBX2_9ACTO (D9VBX2)	1e-42	178	35%	UniProt GenBank	Putative uncharacterized protein	SSMG_03360	Streptomyces sp. AA4
44	Q93KW3_STRVR (Q93KW3)	1e-42	178	33%	UniProt GenBank	Putative glycosyltransferase	aviGT1	Streptomyces viridochromogenes
45	Q9L555_9ACTO (Q9L555)	3e-42	177	31%	UniProt GenBank	AknK	aknK	Streptomyces galilaeus
46	Q2HR28_9ACTO (Q2HR28)	3e-42	177	34%	UniProt GenBank	Putative O-glycosyltransferase	schS9	Streptomyces sp. SCC 2136
47	E5L4T5_9ACTO (E5L4T5)	6e-42	176	32%	UniProt GenBank	Glycosyltransferase		Streptomyces sp. SCSIO 01934
48	B5L6L9_MICCH (B5L6L9)	7e-42	176	37%	UniProt GenBank	Glycosyltransferase		Micromonospora chalcea
49	Q9F826_9ACTO (Q9F826)	8e-42	176	33%	UniProt GenBank	TDP-desosamine glycosyltransferase	megCIII	Micromonospora megalomicea subsp. nigra
50	Q9RN63_STRNO (Q9RN63)	8e-42	176	36%	UniProt GenBank	Putative glycosyl transferase	snogE	Streptomyces nogalater
51	A4FFB3_SACEN (A4FFB3)	1e-41	175	33%	UniProt GenBank	Putative uncharacterized protein	SACE_3464	Saccharopolyspora erythraea (strain NRRL 23338)
52	A1C188_9ACTO (A1C188)	1e-41	175	35%	UniProt GenBank	L-rhamnosyltransferase		Streptomyces echinatus
53	A8Y8I1_STRAM (A8Y8I1)	1e-41	175	32%	UniProt GenBank	Probable glycosyltransferase	srm17	Streptomyces ambofaciens
54	D7B009_NOCDD (D7B009)	3e-41	174	36%	UniProt GenBank	Putative uncharacterized protein	Ndas_4711	Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488) Actinomadura dassonvillei
55	D9SZA9_MICAI (D9SZA9)	6e-41	173	38%	UniProt GenBank	Putative uncharacterized protein	Micau_3719	Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
56	Q8VWB7_9ACTO (Q8VWB7)	6e-41	173	31%	UniProt GenBank	AclK	aclK	Streptomyces galilaeus
57	D9T2A9_MICAI (D9T2A9)	6e-41	173	32%	UniProt GenBank	Putative uncharacterized protein	Micau_4012	Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
58	E8S036_MICSL (E8S036)	6e-41	173	38%	UniProt GenBank	Putative uncharacterized protein	ML5_4680	Micromonospora sp. (strain L5)
59	E0KQM6_STRVO (E0KQM6)	7e-41	172	32%	UniProt GenBank	Putative uncharacterized protein	StrviDRAFT_4953	Streptomyces violaceusniger Tu 4113
60	Q9RPA1_STRFR (Q9RPA1)	1e-40	172	34%	UniProt GenBank	Glycosyl transferase	urdGT1b	Streptomyces fradiae Streptomyces roseoflavus
61	Q9RP99_STRFR (Q9RP99)	1e-40	172	35%	UniProt GenBank	Glycosyl transferase	urdGT1c	Streptomyces fradiae Streptomyces roseoflavus
62	Q83X73_STRRO (Q83X73)	1e-40	172	32%	UniProt GenBank	Glycosyltransferase LkmI	lkmI	Streptomyces rochei Streptomyces parvullus
63	Q0H2X6_9ACTO (Q0H2X6)	2e-40	171	35%	UniProt GenBank	Putative O-glycosyltransferase	atG1	Actinomadura melliaura
64	D7BZS5_STRBB (D7BZS5)	4e-40	170	33%	UniProt GenBank	IroB	SBI_06860	Streptomyces bingchenggensis (strain BCW-1)
65	Q53881_STRS5 (Q53881)	4e-40	170	33%	UniProt GenBank	Glycosyltransferase	dauH	Streptomyces sp. (strain C5)
66	B4VEK6_9ACTO (B4VEK6)	4e-40	170	34%	UniProt GenBank	Chalcosyltransferase	SSAG_06216	Streptomyces sp. Mg1
67	D6MSX4_9ACTO (D6MSX4)	5e-40	170	34%	UniProt GenBank	SsfS6	ssfS6	Streptomyces sp. SF2575
68	Q331Q0_9ACTO (Q331Q0)	7e-40	169	33%	UniProt GenBank	Chalcosyltransferase	gerTII	Streptomyces sp. KCTC 0041BP
69	Q54824_STRPE (Q54824)	7e-40	169	34%	UniProt GenBank	Glycosyl transferase	dnrS	Streptomyces peucetius
70	A4GV85_9ACTO (A4GV85)	9e-40	169	34%	UniProt GenBank	Glycosyltransferase	holC	Streptomyces rufochromogenes
71	Q70J67_STRGR (Q70J67)	1e-39	169	36%	UniProt GenBank	Glycosyltransferase	cmmGII	Streptomyces griseus subsp. griseus
72	Q5SFB5_STRBI (Q5SFB5)	2e-39	168	33%	UniProt GenBank	Putative chalcose glycosyltransferase	chmCIII	Streptomyces bikiniensis
73	D7BZT8_STRBB (D7BZT8)	2e-39	168	35%	UniProt GenBank	Putative uncharacterized protein	SBI_06873	Streptomyces bingchenggensis (strain BCW-1)
74	Q0PY15_STRMY (Q0PY15)	3e-39	167	33%	UniProt GenBank	Glycosyltransferase	midI	Streptomyces mycarofaciens
75	A0ACI7_STRAM (A0ACI7)	3e-39	167	32%	UniProt GenBank	Putative glycosyltransferase	SAMR0481	Streptomyces ambofaciens ATCC 23877
76	D5UX47_TSUPD (D5UX47)	1e-38	165	35%	UniProt GenBank	Putative uncharacterized protein	Tpau_3487	Tsukamurella paurometabola (strain ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040) Corynebacterium paurometabolum
77	D8I4J8_AMYMU (D8I4J8)	2e-38	164	36%	UniProt GenBank	Putative glycosyl transferase	AMED_5412	Amycolatopsis mediterranei (strain U-32)
78	Q9ZGB8_STRCY (Q9ZGB8)	2e-38	164	34%	UniProt GenBank	Glycosyl transferase homolog	lanGT1	Streptomyces cyanogenus
79	D7B025_NOCDD (D7B025)	4e-38	163	35%	UniProt GenBank	Putative uncharacterized protein	Ndas_4727	Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488) Actinomadura dassonvillei
80	A8Y8F5_STRAM (A8Y8F5)	4e-38	163	34%	UniProt GenBank	Probable glycosyltransferase	srm3*c	Streptomyces ambofaciens
81	P95747_STRFR (P95747)	4e-38	163	32%	UniProt GenBank	Glycosyltransferase	tylMII(orf2*)	Streptomyces fradiae Streptomyces roseoflavus
82	D7AZA5_NOCDD (D7AZA5)	9e-38	162	35%	UniProt GenBank	Putative uncharacterized protein	Ndas_4699	Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488) Actinomadura dassonvillei
83	O87830_STRAT (O87830)	9e-38	162	33%	UniProt GenBank	Glycosyltransferase	oleG1	Streptomyces antibioticus
84	Q9L4U6_9ACTO (Q9L4U6)	1e-37	162	35%	UniProt GenBank	Putative glycosyl transferase	aknS	Streptomyces galilaeus
85	E8RWS3_MICSL (E8RWS3)	1e-37	162	34%	UniProt GenBank	Putative uncharacterized protein	ML5_4412	Micromonospora sp. (strain L5)
86	A4GV88_9ACTO (A4GV88)	2e-37	161	31%	UniProt GenBank	Glycosyltransferase	holL	Streptomyces sp. Tu1156
87	E8RWS0_MICSL (E8RWS0)	3e-37	161	32%	UniProt GenBank	Putative uncharacterized protein	ML5_4409	Micromonospora sp. (strain L5)
88	D8I4J7_AMYMU (D8I4J7)	5e-37	160	34%	UniProt GenBank	Putative glycosyl transferase	AMED_5411	Amycolatopsis mediterranei (strain U-32)
89	D9T2A6_MICAI (D9T2A6)	6e-37	160	34%	UniProt GenBank	Putative uncharacterized protein	Micau_4009	Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
90	Q9RIP9_STRNO (Q9RIP9)	6e-37	159	34%	UniProt GenBank	SnogZ	snogZ	Streptomyces nogalater
91	D7AZB3_NOCDD (D7AZB3)	9e-37	159	34%	UniProt GenBank	Putative uncharacterized protein	Ndas_4707	Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488) Actinomadura dassonvillei
92	B3TMP8_9ACTO (B3TMP8)	1e-36	159	37%	UniProt GenBank	Glycosyltransferase	KijC4	Actinomadura kijaniata
93	D8I4J9_AMYMU (D8I4J9)	1e-36	159	33%	UniProt GenBank	Putative glycosyl transferase	AMED_5413	Amycolatopsis mediterranei (strain U-32)
94	D9WNL3_9ACTO (D9WNL3)	1e-36	158	43%	UniProt GenBank	Putative glycosyltransferase	SSOG_05584	Streptomyces himastatinicus ATCC 53653
95	Q9F8U7_9ACTO (Q9F8U7)	3e-36	157	34%	UniProt GenBank	Glycosyl transferase	couM	Streptomyces rishiriensis
96	Q194P5_STRAA (Q194P5)	3e-36	157	35%	UniProt GenBank	Glycosyltransferase	mtmGI	Streptomyces argillaceus
97	D1GLU2_9ACTO (D1GLU2)	4e-36	157	32%	UniProt GenBank	Glycosyltransferase	slgG	Streptomyces lydicus
98	Q7WTE9_9ACTO (Q7WTE9)	7e-36	156	31%	UniProt GenBank	NanG5	nanG5	Streptomyces nanchangensis
99	C4NCL8_9ACTO (C4NCL8)	1e-35	155	33%	UniProt GenBank	Rhamnosyltransferase	cpz31	Streptomyces sp. MK730-62F2
100	Q9L9F5_STRSH (Q9L9F5)	1e-35	155	35%	UniProt GenBank	NovM	novM	Streptomyces spheroides Streptomyces caeruleus

accession

alignment

Evalue

Score

Ident.

link

information

pubmed

Q194Q0_STRAA
(Q194Q0)

0.0

805

100%

Product: Glycosyltransferase
Gene: mtmGIV
Organism: Streptomyces argillaceus

[pubmed all]
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]

D7BZR5_STRBB
(D7BZR5)

2e-78

297

44%

Product: Glycosyl transferase, NDP-D-desosamine: 3-L-mycarosyl erythronolide B
Gene: SBI_06850
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

C0JWA3_9ACTO
(C0JWA3)

2e-64

251

42%

Product: PokGT1
Gene: pokGT1
Organism: Streptomyces diastatochromogenes

1uniprot[Pubmed] 19266534
Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009]

D8I4K4_AMYMU
(D8I4K4)

5e-63

246

41%

Product: Putative glycosyl transferase
Gene: AMED_5418
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

D8I4I4_AMYMU
(D8I4I4)

8e-51

206

38%

Product: Putative glycosyl transferase
Gene: AMED_5398
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

Q0R4P9_STRAT
(Q0R4P9)

9e-51

206

38%

Product: ChlC7
Gene
Organism: Streptomyces antibioticus

1uniprot[Pubmed] 16793515
Genetic characterization of the chlorothricin gene cluster as a model for spirotetronate antibiotic biosynthesis.(Chem. Biol.) [2006]

B3TMN6_9ACTO
(B3TMN6)

1e-50

205

38%

Product: Glycosyltransferase
Gene: KijA4
Organism: Actinomadura kijaniata

1uniprot[Pubmed] 17985890
Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007]

Q194P9_STRAA
(Q194P9)

1e-49

202

37%

Product: Glycosyltransferase
Gene: mtmGIII
Organism: Streptomyces argillaceus

[pubmed all]
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]

B3TMP5_9ACTO
(B3TMP5)

1e-48

199

38%

Product: Glycosyltransferase
Gene: KijC1
Organism: Actinomadura kijaniata

1uniprot[Pubmed] 17985890
Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007]

A4F7P3_SACEN
(A4F7P3)

1e-48

198

34%

Product: Glycosyl transferase, NDP-D-desosamine : 3-L-mycarosyl erythronolide B
Gene: eryCIII
SACE_0726
Organism: Saccharopolyspora erythraea (strain NRRL 23338)

1uniprot[Pubmed] 17369815
Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007]

D8I4K0_AMYMU
(D8I4K0)

3e-48

197

36%

Product: Putative glycosyl transferase
Gene: AMED_5414
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

Q9ZGH7_9ACTO
(Q9ZGH7)

5e-48

196

36%

Product: Glycosyl transferase
Gene: desVII
Organism: Streptomyces venezuelae

1uniprot[Pubmed] 9770448 [Medline] 98445333
A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity.(Proc. Natl. Acad. Sci. U.S.A.) [1998]

O33935_SACER
(O33935)

3e-47

194

34%

Product: Desosaminyltransferase
Gene: eryCIII
Organism: Saccharopolyspora erythraea
Streptomyces erythraeus

1uniprot[Pubmed] 9353926 [Medline] 98015410
Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production.(Microbiology)

B3TMP7_9ACTO
(B3TMP7)

9e-47

192

35%

Product: Glycosyltransferase
Gene: KijC3
Organism: Actinomadura kijaniata

1uniprot[Pubmed] 17985890
Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007]

O87831_STRAT
(O87831)

1e-46

192

35%

Product: Glycosyltransferase
Gene: oleG2
Organism: Streptomyces antibioticus

1uniprot[Pubmed] 9749673 [Medline] 98420102
Analysis of a Streptomyces antibioticus chromosomal region involved in oleandomycin biosynthesis, which encodes two glycosyltransferases responsible for glycosylation of the macrolactone ring.(Mol. Gen. Genet.) [1998]

D2AY79_STRRD
(D2AY79)

2e-46

191

42%

Product: IroB
Gene: Sros_4185
Organism: Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)

1uniprot
Complete genome sequence of Streptosporangium roseum type strain (NI 9100T).(Stand. Genomic Sci.) [2010]

B5L6L8_MICCH
(B5L6L8)

4e-46

190

34%

Product: Glycosyltransferase
Gene
Organism: Micromonospora chalcea

1uniprot[Pubmed] 18586939
Cloning and characterization of the tetrocarcin A gene cluster from Micromonospora chalcea NRRL 11289 reveals a highly conserved strategy for tetronate biosynthesis in spirotetronate antibiotics.(J. Bacteriol.) [2008]

Q4JHQ3_9PSEU
(Q4JHQ3)

7e-46

189

35%

Product: BusP
Gene: busP
Organism: Saccharopolyspora pogona

1uniprot[Pubmed] 16179985
Butenyl-spinosyns, a natural example of genetic engineering of antibiotic biosynthetic genes.(J. Ind. Microbiol. Biotechnol.) [2006]

Q76KZ6_STRHA
(Q76KZ6)

1e-45

189

34%

Product: Glycosyltransferase
Gene: vinC
Organism: Streptomyces halstedii

1uniprot[Pubmed] 15112997
Cloning, sequencing, and functional analysis of the biosynthetic gene cluster of macrolactam antibiotic vicenistatin in Streptomyces halstedii.(Chem. Biol.) [2004]

Q9ALN7_9PSEU
(Q9ALN7)

4e-45

187

34%

Product: Probable NDP-forosamyltransferase
Gene: spnP
Organism: Saccharopolyspora spinosa

1uniprot[Pubmed] 11358695 [Medline] 21257765
Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa.(Chem. Biol.) [2001]

Q9F839_9ACTO
(Q9F839)

5e-45

186

32%

Product: TDP-megosamine glycosyltransferase
Gene: megDI
Organism: Micromonospora megalomicea subsp. nigra

1uniprot[Pubmed] 10972798 [Medline] 20430101
Biosynthesis of the anti-parasitic agent megalomicin: transformation of erythromycin to megalomicin in Saccharopolyspora erythraea.(Mol. Microbiol.) [2000]

D7B014_NOCDD
(D7B014)

5e-45

186

33%

Product: Putative uncharacterized protein
Gene: Ndas_4716
Organism: Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei

1uniprot
Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010]

A4GV89_9ACTO
(A4GV89)

1e-44

185

36%

Product: Glycosyltransferase
Gene: holN
Organism: Streptomyces sp. FU107

1uniprot[Pubmed] 17497146
A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]

Q0R4N0_STRAT
(Q0R4N0)

2e-44

184

35%

Product: ChlC6
Gene
Organism: Streptomyces antibioticus

1uniprot[Pubmed] 16793515
Genetic characterization of the chlorothricin gene cluster as a model for spirotetronate antibiotic biosynthesis.(Chem. Biol.) [2006]

D7BZS3_STRBB
(D7BZS3)

3e-44

184

34%

Product: Glycosyl transferase, NDP-D-desosamine: 3-L-mycarosyl erythronolide B
Gene: SBI_06858
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

D8I4J6_AMYMU
(D8I4J6)

2e-43

181

38%

Product: Putative glycosyl transferase
Gene: AMED_5410
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

C4NYM1_9ACTO
(C4NYM1)

3e-43

181

37%

Product: SaqGT6
Gene: saqGT6
Organism: Micromonospora sp. Tu 6368

[pubmed all]
1uniprot[Pubmed] 17497146 A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]
2uniprot[Pubmed] 19384899 Cloning and sequencing of the biosynthetic gene cluster for saquayamycin z and galtamycin B and the elucidation of the assembly of their saccharide chains.(Chembiochem) [2009]

Q83WE1_MICGR
(Q83WE1)

3e-43

181

34%

Product: Glycosyltransferase
Gene: mycB
Organism: Micromonospora griseorubida

1uniprot[Pubmed] 12583909 [Medline] 22472038
Organization of the biosynthetic gene cluster for the polyketide macrolide mycinamicin in Micromonospora griseorubida.(FEMS Microbiol. Lett.) [2003]

Q2P9Y9_9ACTO
(Q2P9Y9)

3e-43

180

36%

Product: Glycosyl transferase
Gene: stfG
Organism: Streptomyces steffisburgensis

1uniprot[Pubmed] 16751529
Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin.(Appl. Environ. Microbiol.) [2006]

D7BZT2_STRBB
(D7BZT2)

4e-43

180

37%

Product: IroB
Gene: SBI_06867
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

P95834_STRPE
(P95834)

5e-43

180

35%

Product: Putative baumycin biosynthesis protein
Gene: dnrH
Organism: Streptomyces peucetius

[pubmed all]
1uniprot[Pubmed] 8955419 [Medline] 97113559 Enhanced antibiotic production by manipulation of the Streptomyces peucetius dnrH and dnmT genes involved in doxorubicin (adriamycin) biosynthesis.(J. Bacteriol.) [1996]
2uniprot[Pubmed] 9864344 [Medline] 99084971 Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene.(J. Bacteriol.) [1999]

Q5Y9G8_9ACTO
(Q5Y9G8)

6e-43

179

34%

Product: L-desosaminyltransferase
Gene: eryCIII
Organism: Aeromicrobium erythreum

1uniprot[Pubmed] 15257441
The erythromycin biosynthetic gene cluster of Aeromicrobium erythreum.(J. Ind. Microbiol. Biotechnol.) [2004]

Q93KW3_STRVR
(Q93KW3)

1e-42

178

33%

Product: Putative glycosyltransferase
Gene: aviGT1
Organism: Streptomyces viridochromogenes

[pubmed all]
1uniprot[Pubmed] 11410376 [Medline] 21303144 Biosynthesis of the orthosomycin antibiotic avilamycin A: deductions from the molecular analysis of the avi biosynthetic gene cluster of Streptomyces viridochromogenes Tu57 and production of new antibiotics.(Chem. Biol.) [2001]
2uniprot[Pubmed] 15489167 Novel avilamycin derivatives with improved polarity generated by targeted gene disruption.(Chem. Biol.) [2004]

Q9L555_9ACTO
(Q9L555)

3e-42

177

31%

Product: AknK
Gene: aknK
Organism: Streptomyces galilaeus

1uniprot[Pubmed] 12137949 [Medline] 22133312
Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster.(Gene) [2002]

Q2HR28_9ACTO
(Q2HR28)

3e-42

177

34%

Product: Putative O-glycosyltransferase
Gene: schS9
Organism: Streptomyces sp. SCC 2136

1uniprot
Angucyclines Sch 47554 and Sch 47555 from Streptomyces sp. SCC-2136: Cloning, Sequencing, and Characterization.(Mol. Cells) [2006]

2uniprot
Molecular cloning and characterization of biosynthetic genes cluster of Sch 47554 from Streptomyces sp. SCC 2136. [2004]

B5L6L9_MICCH
(B5L6L9)

7e-42

176

37%

Product: Glycosyltransferase
Gene
Organism: Micromonospora chalcea

Q9F826_9ACTO
(Q9F826)

8e-42

176

33%

Product: TDP-desosamine glycosyltransferase
Gene: megCIII
Organism: Micromonospora megalomicea subsp. nigra

Q9RN63_STRNO
(Q9RN63)

8e-42

176

36%

Product: Putative glycosyl transferase
Gene: snogE
Organism: Streptomyces nogalater

[pubmed all]
1uniprot[Pubmed] 9349712 [Medline] 98007868 Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.(Mol. Gen. Genet.) [1997]
2uniprot[Pubmed] 10639368 [Medline] 20106987 Identification of a cyclase gene dictating the C-9 stereochemistry of anthracyclines from Streptomyces nogalater.(Antimicrob. Agents Chemother.) [2000]

A4FFB3_SACEN
(A4FFB3)

1e-41

175

33%

Product: Putative uncharacterized protein
Gene: SACE_3464
Organism: Saccharopolyspora erythraea (strain NRRL 23338)

1uniprot[Pubmed] 17369815
Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007]

A8Y8I1_STRAM
(A8Y8I1)

1e-41

175

32%

Product: Probable glycosyltransferase
Gene: srm17
Organism: Streptomyces ambofaciens

1uniprot
Organization of the biosynthetic gene cluster for the macrolide antibiotic spiramycin in Streptomyces ambofaciens.(Microbiology (Mosc.)) [2007]

D7B009_NOCDD
(D7B009)

3e-41

174

36%

Product: Putative uncharacterized protein
Gene: Ndas_4711
Organism: Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei

1uniprot
Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010]

Q8VWB7_9ACTO
(Q8VWB7)

6e-41

173

31%

Product: AclK
Gene: aclK
Organism: Streptomyces galilaeus

1uniprot[Pubmed] 12399480 [Medline] 22286521
Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus.(J. Bacteriol.) [2002]

Q9RPA1_STRFR
(Q9RPA1)

1e-40

172

34%

Product: Glycosyl transferase
Gene: urdGT1b
Organism: Streptomyces fradiae
Streptomyces roseoflavus

1uniprot[Pubmed] 10658661 [Medline] 20121748
Two new tailoring enzymes, a glycosyltransferase and an oxygenase, involved in biosynthesis of the angucycline antibiotic urdamycin A in Streptomyces fradiae Tu2717.(Microbiology) [2000]

Q9RP99_STRFR
(Q9RP99)

1e-40

172

35%

Product: Glycosyl transferase
Gene: urdGT1c
Organism: Streptomyces fradiae
Streptomyces roseoflavus

Q83X73_STRRO
(Q83X73)

1e-40

172

32%

Product: Glycosyltransferase LkmI
Gene: lkmI
Organism: Streptomyces rochei
Streptomyces parvullus

[pubmed all]
1uniprot[Pubmed] 12791134 [Medline] 22676866 The large linear plasmid pSLA2-L of Streptomyces rochei has an unusually condensed gene organization for secondary metabolism.(Mol. Microbiol.) [2003]
2uniprot[Pubmed] 10954087 [Medline] 20408175 Cloning and analysis of the replication origin and the telomeres of the large linear plasmid pSLA2-L in Streptomyces rochei.(Mol. Gen. Genet.) [2000]
3uniprot[Pubmed] 10767533 [Medline] 20231737 Identification of two polyketide synthase gene clusters on the linear plasmid pSLA2-L in Streptomyces rochei.(Gene) [2000]
4uniprot[Pubmed] 9836424 [Medline] 99053144 Physical mapping of the linear plasmid pSLA2-L and localization of the eryAI and actI homologs.(Biosci. Biotechnol. Biochem.) [1998]

Q0H2X6_9ACTO
(Q0H2X6)

2e-40

171

35%

Product: Putative O-glycosyltransferase
Gene: atG1
Organism: Actinomadura melliaura

1uniprot[Pubmed] 16873021
Deciphering indolocarbazole and enediyne aminodideoxypentose biosynthesis through comparative genomics: insights from the AT2433 biosynthetic locus.(Chem. Biol.) [2006]

D7BZS5_STRBB
(D7BZS5)

4e-40

170

33%

Product: IroB
Gene: SBI_06860
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

Q53881_STRS5
(Q53881)

4e-40

170

33%

Product: Glycosyltransferase
Gene: dauH
Organism: Streptomyces sp. (strain C5)

1uniprot[Pubmed] 8655529 [Medline] 96236066
Cloning, sequencing, and analysis of aklaviketone reductase from Streptomyces sp. strain C5.(J. Bacteriol.) [1996]

D6MSX4_9ACTO
(D6MSX4)

5e-40

170

34%

Product: SsfS6
Gene: ssfS6
Organism: Streptomyces sp. SF2575

1uniprot[Pubmed] 19908837
Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.(J. Am. Chem. Soc.) [2009]

Q331Q0_9ACTO
(Q331Q0)

7e-40

169

33%

Product: Chalcosyltransferase
Gene: gerTII
Organism: Streptomyces sp. KCTC 0041BP

1uniprot[Pubmed] 17053005
Biosynthesis of dTDP-6-deoxy-beta-D-allose, biochemical characterization of dTDP-4-keto-6-deoxyglucose reductase (GerKI) from Streptomyces sp. KCTC 0041BP.(Glycobiology) [2007]

2uniprot
Cloning and characterization of a gene cluster for the production of the polyketide macrolide antibiotic dihydrochalcomycin in Streptomyces sp. KCTC 0041BP.(J. Microbiol. Biotechnol.) [2006]

Q54824_STRPE
(Q54824)

7e-40

169

34%

Product: Glycosyl transferase
Gene: dnrS
Organism: Streptomyces peucetius

1uniprot[Pubmed] 7592454 [Medline] 96062261
Cloning and characterization of the Streptomyces peucetius dnrQS genes encoding a daunosamine biosynthesis enzyme and a glycosyl transferase involved in daunorubicin biosynthesis.(J. Bacteriol.) [1995]

A4GV85_9ACTO
(A4GV85)

9e-40

169

34%

Product: Glycosyltransferase
Gene: holC
Organism: Streptomyces rufochromogenes

1uniprot[Pubmed] 17497146
A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]

Q5SFB5_STRBI
(Q5SFB5)

2e-39

168

33%

Product: Putative chalcose glycosyltransferase
Gene: chmCIII
Organism: Streptomyces bikiniensis

1uniprot[Pubmed] 15561847
Chalcomycin biosynthesis gene cluster from Streptomyces bikiniensis: novel features of an unusual ketolide produced through expression of the chm polyketide synthase in Streptomyces fradiae.(Antimicrob. Agents Chemother.) [2004]

D7BZT8_STRBB
(D7BZT8)

2e-39

168

35%

Product: Putative uncharacterized protein
Gene: SBI_06873
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

Q0PY15_STRMY
(Q0PY15)

3e-39

167

33%

Product: Glycosyltransferase
Gene: midI
Organism: Streptomyces mycarofaciens

1uniprot[Pubmed] 17342257
Cloning and characterization of genes encoded in dTDP-D-mycaminose biosynthetic pathway from a midecamycin-producing strain, Streptomyces mycarofaciens.(Acta Biochim. Biophys. Sin.) [2007]

A0ACI7_STRAM
(A0ACI7)

3e-39

167

32%

Product: Putative glycosyltransferase
Gene: SAMR0481
Organism: Streptomyces ambofaciens ATCC 23877

1uniprot[Pubmed] 16956972
Evolution of the terminal regions of the Streptomyces linear chromosome.(Mol. Biol. Evol.) [2006]

2uniprot
Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877.(Microbiology (Mosc.)) [2006]

D8I4J8_AMYMU
(D8I4J8)

2e-38

164

36%

Product: Putative glycosyl transferase
Gene: AMED_5412
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

Q9ZGB8_STRCY
(Q9ZGB8)

2e-38

164

34%

Product: Glycosyl transferase homolog
Gene: lanGT1
Organism: Streptomyces cyanogenus

1uniprot[Pubmed] 9933932 [Medline] 99132695
Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin biosynthesis.(FEMS Microbiol. Lett.) [1999]

D7B025_NOCDD
(D7B025)

4e-38

163

35%

Product: Putative uncharacterized protein
Gene: Ndas_4727
Organism: Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei

1uniprot
Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010]

A8Y8F5_STRAM
(A8Y8F5)

4e-38

163

34%

Product: Probable glycosyltransferase
Gene: srm3*c
Organism: Streptomyces ambofaciens

1uniprot
Organization of the biosynthetic gene cluster for the macrolide antibiotic spiramycin in Streptomyces ambofaciens.(Microbiology (Mosc.)) [2007]

P95747_STRFR
(P95747)

4e-38

163

32%

Product: Glycosyltransferase
Gene: tylMII(orf2*)
Organism: Streptomyces fradiae
Streptomyces roseoflavus

1uniprot[Pubmed] 9031628 [Medline] 97183662
Analysis of four tylosin biosynthetic genes from the tylLM region of Streptomyces fradiae.(Gene) [1997]

D7AZA5_NOCDD
(D7AZA5)

9e-38

162

35%

Product: Putative uncharacterized protein
Gene: Ndas_4699
Organism: Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei

1uniprot
Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010]

O87830_STRAT
(O87830)

9e-38

162

33%

Product: Glycosyltransferase
Gene: oleG1
Organism: Streptomyces antibioticus

Q9L4U6_9ACTO
(Q9L4U6)

1e-37

162

35%

Product: Putative glycosyl transferase
Gene: aknS
Organism: Streptomyces galilaeus

1uniprot[Pubmed] 11016846 [Medline] 20469061
A gene cluster from Streptomyces galilaeus involved in glycosylation of aclarubicin.(Mol. Gen. Genet.) [2000]

A4GV88_9ACTO
(A4GV88)

2e-37

161

31%

Product: Glycosyltransferase
Gene: holL
Organism: Streptomyces sp. Tu1156

1uniprot[Pubmed] 17497146
A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007]

D8I4J7_AMYMU
(D8I4J7)

5e-37

160

34%

Product: Putative glycosyl transferase
Gene: AMED_5411
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

Q9RIP9_STRNO
(Q9RIP9)

6e-37

159

34%

Product: SnogZ
Gene: snogZ
Organism: Streptomyces nogalater

[pubmed all]
1uniprot[Pubmed] 8668120 [Medline] 96242142 A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.(Mol. Gen. Genet.) [1996]
2uniprot[Pubmed] 9349712 [Medline] 98007868 Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis.(Mol. Gen. Genet.) [1997]
3uniprot[Pubmed] 8760909 [Medline] 96349102 Production of hybrid anthracycline antibiotics by heterologous expression of Streptomyces nogalater nogalamycin biosynthesis genes.(Microbiology) [1996]

D7AZB3_NOCDD
(D7AZB3)

9e-37

159

34%

Product: Putative uncharacterized protein
Gene: Ndas_4707
Organism: Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei

1uniprot
Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010]

B3TMP8_9ACTO
(B3TMP8)

1e-36

159

37%

Product: Glycosyltransferase
Gene: KijC4
Organism: Actinomadura kijaniata

1uniprot[Pubmed] 17985890
Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007]

D8I4J9_AMYMU
(D8I4J9)

1e-36

159

33%

Product: Putative glycosyl transferase
Gene: AMED_5413
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

Q9F8U7_9ACTO
(Q9F8U7)

3e-36

157

34%

Product: Glycosyl transferase
Gene: couM
Organism: Streptomyces rishiriensis

1uniprot[Pubmed] 11036020 [Medline] 20493109
Identification of the coumermycin A(1) biosynthetic gene cluster of Streptomyces rishiriensis DSM 40489.(Antimicrob. Agents Chemother.) [2000]

Q194P5_STRAA
(Q194P5)

3e-36

157

35%

Product: Glycosyltransferase
Gene: mtmGI
Organism: Streptomyces argillaceus

[pubmed all]
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]

D1GLU2_9ACTO
(D1GLU2)

4e-36

157

32%

Product: Glycosyltransferase
Gene: slgG
Organism: Streptomyces lydicus

1uniprot
Deciphering biosynthesis of the RNA polymerase inhibitor streptolydigin and generation of glycosylated derivatives.(Chem. Biol.) [2009]

Q7WTE9_9ACTO
(Q7WTE9)

7e-36

156

31%

Product: NanG5
Gene: nanG5
Organism: Streptomyces nanchangensis

1uniprot[Pubmed] 12770825 [Medline] 22654646
A complete gene cluster from Streptomyces nanchangensis NS3226 encoding biosynthesis of the polyether ionophore nanchangmycin.(Chem. Biol.) [2003]

C4NCL8_9ACTO
(C4NCL8)

1e-35

155

33%

Product: Rhamnosyltransferase
Gene: cpz31
Organism: Streptomyces sp. MK730-62F2

1uniprot[Pubmed] 19351877
Identification and manipulation of the caprazamycin gene cluster leads to new simplified liponucleoside antibiotics and gives insights into the biosynthetic pathway.(J. Biol. Chem.) [2009]

100

Q9L9F5_STRSH
(Q9L9F5)

1e-35

155

35%

Product: NovM
Gene: novM
Organism: Streptomyces spheroides
Streptomyces caeruleus

1uniprot[Pubmed] 10770754 [Medline] 20233587
Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891.(Antimicrob. Agents Chemother.) [2000]