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Rule : Phosphoserine aminotransferase (SERC)

Rule Description

ID NRULE_0210
Rule name SERC
Created 2013-05-09
Protein name
Protein name
Full
Phosphoserine aminotransferase
EC
EC 2.6.1.52
Synonym
Full
Phosphohydroxythreonine aminotransferase
Short
PSAT
Gene name serC
Rule Trigger HAMAP; MF_00160; hit=1
Cross Reference
Gene Ontology
GO
GO:0005737, C:cytoplasm, IEA:UniProtKB-SubCell
GO:0004648, F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity, IDA:EcoCyc
GO:0030170, F:pyridoxal phosphate binding, IEA:HAMAP
GO:0006564, P:L-serine biosynthetic process, IMP:EcoCyc
GO:0042823, P:pyridoxal phosphate biosynthetic process, IMP:EcoCyc
GO:0008615, P:pyridoxine biosynthetic process, IEA:HAMAP
Phylogenomic databases
eggNOG
COG1932, -
HOGENOM
HOG000088965, -
KO
K00831, -
ProtClustDB
PRK05355, -
Enzyme and pathway databases
BioCyc
MetaCyc:PSERTRANSAM-MONOMER, -
UniPathway
UPA00135, UER00197
UPA00244, UER00311
Family and domain databases
HAMAP
MF_00160, SerC_aminotrans_5, 1, -
InterPro
IPR000192, Aminotrans_V/Cys_dSase
IPR020578, Aminotrans_V_PyrdxlP_BS
IPR022278, Pser_aminoTfrase
IPR003248, Pser_aminoTfrase_subgr
IPR015424, PyrdxlP-dep_Trfase
IPR015421, PyrdxlP-dep_Trfase_major_sub1
IPR015422, PyrdxlP-dep_Trfase_major_sub2
Pfam
PF00266, Aminotran_5, 1
PIRSF
PIRSF000525, SerC, 1
TIGRFAMs
TIGR01364, serC_1, 1
PROSITE
PS00595, AA_TRANSFER_CLASS_5, 1
Feature
P23721 Escherichia coli (strain K12).
BINDING9L-glutamate.
BINDING42L-glutamate.
BINDING102Pyridoxal phosphate.
BINDING153Pyridoxal phosphate.
BINDING174Pyridoxal phosphate.
BINDING197Pyridoxal phosphate.
MOD_RES198N6-(pyridoxal phosphate)lysine.
General annotation
Function
Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
Catalytic activity
O-phospho-L-serine + 2-oxoglutarate = 3- phosphonooxypyruvate + L-glutamate
4-phosphonooxy-L-threonine + 2-oxoglutarate = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate
Cofactor
Binds 1 pyridoxal phosphate per subunit (By similarity)
Pathway
Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3
Reference
P23721 Escherichia coli (strain K12).
3518706
The serC-aro A operon of Escherichia coli. A mixed function operon encoding enzymes from two different amino acid biosynthetic pathways. (Biochem J. 1986)
8905232
A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map. (DNA Res. 1996)
9278503
The complete genome sequence of Escherichia coli K-12. (Science. 1997)
16738553
Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. (Mol Syst Biol. 2006)
2121717
Metabolic relationships between pyridoxine (vitamin B6) and serine biosynthesis in Escherichia coli K-12. (J Bacteriol. 1990)
8706854
4-O-phosphoryl-L-threonine, a substrate of the pdxC(serC) gene product involved in vitamin B6 biosynthesis. (FEBS Lett. 1996)



Related Function

Function name
Vitamin B6 biosynthesis (PdxA/PdxJ pathway)

CDS

Data Download
Scientific name NBRC No. CDS Product name
Acidithiobacillus ferrooxidansLferr_1017phosphoserine aminotransferase
Acinetobacter radioresistens102413ACRAD_02_00880phosphoserine aminotransferase
Acinetobacter sp.100985ACT4_023_00560phosphoserine aminotransferase
Actinoalloteichus cyanogriseus14455G443_01_05910phosphoserine aminotransferase
Actinoalloteichus spitiensis102582ACTIDRAF_05260phosphoserine aminotransferase
Actinomadura atramentaria14695G339_00285phosphoserine aminotransferase
Actinopolyspora iraqiensis103187ACTIR_677_00020phosphoserine aminotransferase
Actinosynnema mirum14064Amir_0514phosphoserine aminotransferase
Aerococcus viridans12219HMPREF0061_0990phosphoserine transaminase
Alicyclobacillus acidocaldarius subsp. acidocaldarius15652Aaci_1232phosphoserine aminotransferase
Alteromonas macleodii102226MASE_101103-phosphoserine/phosphohydroxythreonine aminotransferase
Amycolatopsis azurea14573C791_2596Phosphoserine aminotransferase
Amycolatopsis mediterranei13415RAM_43430phosphoserine aminotransferase
Anaerolinea thermophila100420ANT_30620phosphoserine aminotransferase
Anoxybacillus flavithermus15317Aflv_2293Phosphoserine aminotransferase
Aquimarina agarilytica107695AagaZ_0201000101783-phosphoserine/phosphohydroxythreonine aminotransferase
Bacillus amyloliquefaciens15535BAMF_1096phosphoserine aminotransferase
Bacillus atrophaeus13721BATRMS_10_07800phosphoserine aminotransferase
Bacillus cereus15305BC_3249Phosphoserine aminotransferase
Bacillus licheniformis12200BL05093phosphoserine aminotransferase
Bacillus licheniformis12195BLi01082phosphoserine aminotransferase apoenzyme SerC
Bacillus mojavensis15718GYU_14_00710phosphoserine aminotransferase
Bacillus mycoides101228bmyco0001_29130Phosphoserine aminotransferase
Bacillus pseudomycoides101232bpmyx0001_26420Phosphoserine aminotransferase
Bacillus psychrosaccharolyticus101233WYK_260_00260phosphoserine aminotransferase
Bacillus pumilus12092BAT_3119phosphoserine aminotransferase
Bacillus subtilis3134BSU6633_15022phosphoserine aminotransferase
Bacillus subtilis subsp. subtilis13719BSU10020phosphoserine aminotransferase
Bacillus thuringiensis101235bthur0008_29810Phosphoserine aminotransferase
Bacillus vallismortis101236BvalD_0101000086283-phosphoserine/phosphohydroxythreonine aminotransferase
Bacteroides vulgatus14291BVU_3241phosphoserine aminotransferase
Balneola vulgarisB155_RS0111530phosphoserine transaminase
Bergeyella zoohelcum16014HMPREF9699_01218phosphoserine transaminase
Brevibacterium linens12170BlinB_010200003002phosphoserine aminotransferase
Cellulophaga lytica14961Celly_2990Phosphoserine aminotransferase
Chitinispirillum alkaliphilumCHISP_0245Phosphoserine aminotransferase
Chitinivibrio alkaliphilusCALK_0666phosphoserine aminotransferase
Chitinophaga pinensis15968Cpin_1139phosphoserine aminotransferase
Chloracidobacterium thermophilum BCabther_A0876phosphoserine aminotransferase apoenzyme
Chromobacterium violaceum12614CV_2301phosphoserine transaminase
Chryseobacterium gleum15054HMPREF0204_14177putative phosphoserine transaminase
Chthonomonas calidiroseaCCALI_00700phosphoserine aminotransferase apoenzyme
Congregibacter litoralis104960KT71_10814phosphoserine aminotransferase apoenzyme
Corynebacterium ammoniagenes12612HMPREF0281_00819putative phosphoserine transaminase
Corynebacterium glutamicum12153KIQ_10466phosphoserine aminotransferase
Corynebacterium striatum15291HMPREF0308_0527putative phosphoserine transaminase
Corynebacterium terpenotabidum14764A606_02830phosphoserine aminotransferase
Cupriavidus metallidurans102507Rmet_07153-phosphoserine/phosphohydroxythreonine aminotransferase
Cystobacter fuscus100088D187_001751Phosphoserine aminotransferase
Edwardsiella tarda105688ET1_21_00680phosphoserine aminotransferase
Enterobacter aerogenes13534EAE_151403-phosphoserine/phosphohydroxythreonine aminotransferase
Enterobacter cloacae subsp. cloacae13535ECL_02746phosphoserine aminotransferase
Enterobacter hormaechei105718HMPREF9086_0917phosphoserine transaminase
Enterococcus gilvus100696I592_03461phosphoserine transaminase
Enterococcus haemoperoxidus100709I583_02779phosphoserine aminotransferase
Enterococcus italicus107825HMPREF9088_1873phosphoserine transaminase
Enterococcus moraviensis100710I586_02565phosphoserine transaminase
Enterococcus pallens100697I588_00090phosphoserine aminotransferase
Enterococcus phoeniculicola100711I589_03312phosphoserine transaminase
Escherichia coli3972EcolC_2689phosphoserine aminotransferase
Escherichia coli13500WFL_049453-phosphoserine/phosphohydroxythreonine aminotransferase
Escherichia coli12713Y75_08833-phosphoserine/phosphohydroxythreonine aminotransferase
Escherichia fergusonii102419EFER_10523-phosphoserine/phosphohydroxythreonine aminotransferase
Escherichia hermannii105704EH105704_01_04740phosphoserine aminotransferase
Fibrobacter succinogenesFisuc_0581Phosphoserine transaminase
Fimbriimonas ginsengisoliOP10G_2941phosphoserine aminotransferase
Flavobacterium johnsoniae14942Fjoh_2462aminotransferase
Fluviicola taffensis106335Fluta_3594Phosphoserine aminotransferase
Frateuria aurantia3245Fraau_1191phosphoserine aminotransferase
Fraau_2069phosphoserine aminotransferase
Geodermatophilus obscurus13315Gobs_0829phosphoserine aminotransferase
Gordonia aichiensis108223GOACH_07_00770phosphoserine aminotransferase
Gordonia alkanivorans16433GOALK_131_00210phosphoserine aminotransferase
Gordonia amarae15530GOAMR_52_00400phosphoserine aminotransferase
Gordonia amicalis100051GOAMI_16_00120phosphoserine aminotransferase
Gordonia araii100433GOARA_056_01190phosphoserine aminotransferase
Gordonia bronchialis16047Gbro_1258phosphoserine aminotransferase
Gordonia effusa100432GOEFS_037_00250phosphoserine aminotransferase
Gordonia hirsuta16056GOHSU_21_00250phosphoserine aminotransferase
Gordonia namibiensis108229GONAM_48_00040phosphoserine aminotransferase
Gordonia otitidis100426GOOTI_123_00020phosphoserine aminotransferase
Gordonia polyisoprenivorans16320GOPIP_011_00250phosphoserine aminotransferase
Gordonia rubripertincta101908GORBP_049_00600phosphoserine aminotransferase
Gordonia sihwensis108236GSI01S_02_00280phosphoserine aminotransferase
Gordonia soli108243GS4_14_01290phosphoserine aminotransferase
Gordonia sputi100414GOSPT_079_00100phosphoserine aminotransferase
Gordonia terrae100016GOTRE_039_01850phosphoserine aminotransferase
Halomonas elongata15536HELO_2720phosphoserine aminotransferase
Herpetosiphon aurantiacusHaur_1719phosphoserine aminotransferase
Holophaga foetidaHOLFODRAFT_RS0206955MFS transporter
Hylemonella gracilis14920HGR_057563-phosphoserine/phosphohydroxythreonine aminotransferase
Ignavibacterium album101810IALB_0155Phosphoserine aminotransferase
Intrasporangium calvum12989Intca_0746phosphoserine aminotransferase apoenzyme
Kitasatospora setae14216KSE_44680putative phosphoserine aminotransferase
Klebsiella pneumoniae14438KPR_3643
Klebsiella pneumoniae subsp. rhinoscleromatis105682HMPREF0484_1231phosphoserine transaminase
Kordia algicida100336KAOT1_07648phosphoserine aminotransferase
Kyrpidia tusciae15312Btus_1006phosphoserine aminotransferase
Lactobacillus animalis15882LaniK3_0101000021623-phosphoserine/phosphohydroxythreonine aminotransferase
Lactobacillus farciminis107150LfarK3_0101000061303-phosphoserine/phosphohydroxythreonine aminotransferase
Lactobacillus fermentum15885HMPREF0511_0781putative phosphoserine transaminase
Lactobacillus fermentum3956LAF_0768phosphoserine aminotransferase
Lactobacillus hilgardii15886HMPREF0519_1271phosphoserine transaminase
Lactobacillus plantarum subsp. plantarum15891HMPREF0531_10275phosphoserine transaminase
Leptospira interrogansLA_0366phosphoserine aminotransferase
Leuconostoc lactis107866EY7_163_00010Phosphoserine aminotransferase
Leuconostoc mesenteroides subsp. cremoris107766HMPREF0555_0902putative phosphoserine transaminase
Leuconostoc mesenteroides subsp. mesenteroides100496LEUM_1464phosphoserine aminotransferase apoenzyme
Leuconostoc pseudomesenteroides107767LpseK3_010100016129MFS transporter
Marinomonas mediterranea103028Marme_1464Phosphoserine aminotransferase
Mariprofundus ferrooxydansSPV1_02302phosphoserine aminotransferase
Micrococcus luteus3333Mlut_04180phosphoserine aminotransferase, Methanosarcina type/phosphoserine aminotransferase, putative
Microlunatus phosphovorus101784MLP_46140phosphoserine aminotransferase
Mobilicoccus pelagius104925MOPEL_091_00160phosphoserine aminotransferase
Myroides odoratus14945Myrod_0842phosphoserine aminotransferase apoenzyme
Nakamurella multipartita105858Namu_4709phosphoserine aminotransferase
Niastella koreensis106392Niako_5812phosphoserine aminotransferase apoenzyme
Nitrosomonas europaea14298NE0333Aminotransferase class-V:Phosphoserine aminotransferase
Nocardiopsis dassonvillei14626Ndas_4171phosphoserine aminotransferase
Oscillibacter valericigenes101213OBV_26750phosphoserine aminotransferase
Paenibacillus alvei3343PAV_16c00340phosphoserine aminotransferase SerC
Paenibacillus peoriae15541PpeoK3_0101000222483-phosphoserine/phosphohydroxythreonine aminotransferase
Paenibacillus polymyxa15309PPT_08255MFS transporter
Pedobacter heparinus12017Phep_1857phosphoserine aminotransferase
Pedobacter saltans100064Pedsa_1000phosphoserine aminotransferase apoenzyme
Pelobacter propionicus103807Ppro_0735phosphoserine aminotransferase apoenzyme
Photobacterium damselae subsp. damselae corrig.15633VDA_002369phosphoserine aminotransferase
Phycisphaera mikurensis102666PSMK_19300phosphoserine aminotransferase
Planctomyces brasiliensis103401Plabr_0485phosphoserine aminotransferase apoenzyme
Proteus mirabilis105697HMPREF0693_2064phosphoserine transaminase
Providencia alcalifaciens105687PROVALCAL_00837phosphoserine transaminase
Pseudomonas putida100650PP_17683-phosphoserine aminotransferase
Pseudomonas stutzeri14165PSTAB_2222phosphoserine aminotransferase
Rahnella aquatilis105701Rahaq2_1562phosphoserine aminotransferase
Rahaq2_3295phosphoserine aminotransferase
Rhodococcus erythropolis100887RER_46170phosphoserine aminotransferase
Rhodococcus opacus108011ROP_50530phosphoserine aminotransferase
Saccharomonospora azurea14651SacazDRAFT_02141phosphoserine aminotransferase, putative
Saccharomonospora cyanea14841SaccyDRAFT_4480phosphoserine aminotransferase, putative
Saccharomonospora glauca14831SacglDRAFT_03750phosphoserine aminotransferase, putative
Saccharomonospora viridis12207Svir_33860phosphoserine aminotransferase, putative
Saccharopolyspora erythraea13426SACE_0630phosphoserine aminotransferase
Saccharopolyspora spinosa15153SspiN1_010100022130phosphoserine aminotransferase
Saccharothrix espanaensis15066BN6_05490Phosphoserine aminotransferase
Salinibacter ruberSRU_2207phosphoserine aminotransferase
Sanguibacter keddieii16158Sked_30790phosphoserine aminotransferase
Selenomonas ruminantium subsp. lactilytica103574SELR_09980putative phosphoserine aminotransferase
Serratia odorifera102598HMPREF0758_4386phosphoserine transaminase
Shimwellia blattae105725EB105725_03_01360phosphoserine aminotransferase
Solitalea canadensis15130Solca_1811phosphoserine aminotransferase
Sphingobacterium spiritivorum14948HMPREF0766_13518phosphoserine transaminase
Sporichthya polymorpha12702Spopo_30_18790Phosphoserine aminotransferase
Streptococcus equinus12553HMPREF0819_1011phosphoserine transaminase
Streptomyces avermitilis14893SAV3883putative aminotransferase
Streptomyces cattleya14057SCAT_2402Phosphoserine aminotransferase
Streptomyces clavuligerus13307SCLAV_3352Phosphoserine aminotransferase
Streptomyces ghanaensis15414SSFG_04039phosphoserine aminotransferase
Streptomyces mobaraensis13819H340_009043-phosphoserine/phosphohydroxythreonine aminotransferase
H340_28425phosphoserine aminotransferase
Streptomyces pristinaespiralis13074SSDG_06648phosphoserine aminotransferase
Streptomyces purpureus13925STRPU_10_03730Putative phosphoserine transaminase
Streptomyces sviceus13980SSEG_00216phosphoserine aminotransferase
Streptomyces venezuelae13096SVEN_4162Phosphoserine aminotransferase
Streptosporangium roseum3776Sros_1004Phosphoserine aminotransferase-like protein
Tetragenococcus halophilus12172TEH_03040phosphoserine aminotransferase
Thauera linaloolentis102519C666_027453-phosphoserine/phosphohydroxythreonine aminotransferase
Thermobispora bispora14880Tbis_0519phosphoserine aminotransferase
Thermomonospora curvata15933Tcur_0832phosphoserine aminotransferase
Tsukamurella paurometabola16120Tpau_0847phosphoserine aminotransferase
Turicella otitidis106139HMPREF9719_01073phosphoserine aminotransferase
Vibrio alginolyticus15630N646_0284phosphoserine aminotransferase
Vibrio ichthyoenteri15847VII00023_21242phosphoserine aminotransferase
Vibrio metschnikovii103153VIB_001055phosphoserine aminotransferase
Vibrio orientalis15638VIOR3934_045393-phosphoserine/phosphohydroxythreonine aminotransferase
Vibrio tubiashii15644VITU9109_234203-phosphoserine/phosphohydroxythreonine aminotransferase
Vibrio vulnificus15645B736_025203-phosphoserine/phosphohydroxythreonine aminotransferase
Weeksella virosa16016Weevi_0417Phosphoserine aminotransferase
Yersinia bercovieri105717yberc0001_26030Phosphoserine aminotransferase
Yersinia rohdei105715yrohd0001_30930Phosphoserine aminotransferase