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遺伝子 : 4-hydroxythreonine-4-phosphate dehydrogenase (PDXA)

遺伝子情報

ID NRULE_0211
遺伝子ID PDXA
作成日 2013/05/09
タンパク質名
Protein name
Full
4-hydroxythreonine-4-phosphate dehydrogenase
EC
EC 1.1.1.262
Synonym
Full
4-(phosphohydroxy)-L-threonine dehydrogenase
遺伝子名 pdxA
遺伝子条件 HAMAP; MF_00536; hit=1
参照
Gene Ontology
GO
GO:0005737, C:cytoplasm, IEA:UniProtKB-SubCell
GO:0050570, F:4-hydroxythreonine-4-phosphate dehydrogenase activity, IDA:EcoCyc
GO:0050897, F:cobalt ion binding, IEA:HAMAP
GO:0000287, F:magnesium ion binding, IDA:EcoCyc
GO:0051287, F:NAD binding, IDA:EcoCyc
GO:0008270, F:zinc ion binding, IDA:EcoCyc
GO:0042823, P:pyridoxal phosphate biosynthetic process, IMP:EcoCyc
GO:0008615, P:pyridoxine biosynthetic process, IMP:EcoCyc
Phylogenomic databases
eggNOG
COG1995, -
HOGENOM
HOG000221592, -
KO
K00097, -
ProtClustDB
PRK00232, -
Enzyme and pathway databases
BioCyc
MetaCyc:PDXA-MONOMER, -
UniPathway
UPA00244, UER00312
Family and domain databases
HAMAP
MF_00536, PdxA, 1, -
InterPro
IPR024084, IsoPropMal-DH-like_dom
IPR005255, PyrdxlP_synth_PdxA
Pfam
PF04166, PdxA, 1
TIGRFAMs
TIGR00557, pdxA, 1
配列の特徴
P19624 Escherichia coli (strain K12).
METAL166Divalent metal cation; shared with dimeric partner.
METAL211Divalent metal cation; shared with dimeric partner.
METAL266Divalent metal cation; shared with dimeric partner.
BINDING136Substrate.
BINDING137Substrate.
BINDING274Substrate.
BINDING283Substrate.
BINDING292Substrate.
注釈
Function
Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
Catalytic activity
4-(phosphonooxy)-L-threonine + NAD(+) = (2S)- 2-amino-3-oxo-4-phosphonooxybutanoate + NADH
参考文献
P19624 Escherichia coli (strain K12).
2670894
Overlap between pdxA and ksgA in the complex pdxA-ksgA-apaG-apaH operon of Escherichia coli K-12. (J Bacteriol. 1989)
1630901
Systematic sequencing of the Escherichia coli genome: analysis of the 0-2.4 min region. (Nucleic Acids Res. 1992)
9278503
The complete genome sequence of Escherichia coli K-12. (Science. 1997)
16738553
Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. (Mol Syst Biol. 2006)
15026039
Biosynthesis of vitamin B6: direct identification of the product of the PdxA-catalyzed oxidation of 4-hydroxy-l-threonine-4-phosphate using electrospray ionization mass spectrometry. (Bioorg Med Chem Lett. 2004)



関与する機能

機能名
Vitamin B6 biosynthesis (PdxA/PdxJ pathway)

該当CDS

データダウンロード
学名 NBRC番号 CDS タンパク質名
Acaryochloris marina102967AM1_45544-hydroxythreonine-4-phosphate dehydrogenase
Acetobacter aceti14818AaceN1_010100003493pyridoxal phosphate biosynthetic protein PdxA
Acetobacter pasteurianus105190APA32_21780Pyridoxal phosphate biosynthetic protein PdxA
Acetobacter pasteurianus101655APT_2445pyridoxal phosphate biosynthetic protein PdxA
Acetobacter tropicalis101654ATPR_2630pyridoxal phosphate biosynthetic protein PdxA
Acidiphilium multivorum100883ACMV_075404-hydroxythreonine-4-phosphate dehydrogenase
ACMV_295604-hydroxythreonine-4-phosphate dehydrogenase
Acidithiobacillus ferrooxidansLferr_03444-hydroxythreonine-4-phosphate dehydrogenase
Acinetobacter radioresistens102413ACRAD_12_000704-hydroxythreonine-4-phosphate dehydrogenase
Acinetobacter sp.100985ACT4_033_005704-hydroxythreonine-4-phosphate dehydrogenase
Alteromonas macleodii102226MASE_031804-hydroxythreonine-4-phosphate dehydrogenase
Amycolatopsis mediterranei13415RAM_119054-hydroxythreonine-4-phosphate dehydrogenase
Aquifex aeolicusaq_852pyridoxal phosphate biosynthetic protein PdxA
Aquimarina agarilytica107695AagaZ_0201000053054-hydroxythreonine-4-phosphate dehydrogenase
Arthrobacter globiformis12137ARGLB_037_022704-hydroxythreonine-4-phosphate dehydrogenase
Azorhizobium caulinodans14845AZC_01754-hydroxythreonine-4-phosphate dehydrogenase
AZC_43214-hydroxythreonine-4-phosphate dehydrogenase
Bacillus licheniformis12200BL03434putative 4-hydroxythreonine-4-phosphate dehydrogenase
Bacillus licheniformis12195BLi036994-hydroxythreonine-4-phosphate dehydrogenase PdxA
Bacteroides vulgatus14291BVU_26004-hydroxythreonine-4-phosphate dehydrogenase
Balneola vulgarisB155_RS01018204-hydroxythreonine-4-phosphate dehydrogenase PdxA
Bergeyella zoohelcum16014HMPREF9699_020924-hydroxythreonine-4-phosphate dehydrogenase
Bradyrhizobium diazoefficiens14792bll4103pyridoxal phosphate biosynthesis protein
blr3887pyridoxal phosphate biosynthesis protein
blr4374pyridoxal phosphate biosynthesis protein
Brevibacterium linens12170BlinB_0102000015024-hydroxythreonine-4-phosphate dehydrogenase
BlinB_0102000164274-hydroxythreonine-4-phosphate dehydrogenase
Brevundimonas diminuta12697BDIM_182104-hydroxythreonine-4-phosphate dehydrogenase
Brevundimonas subvibrioides16000Bresu_25844-hydroxythreonine-4-phosphate dehydrogenase
Calditerrivibrio nitroreducens101217Calni_07724-hydroxythreonine-4-phosphate dehydrogenase
Candidatus Korarchaeum cryptofilumKcr_14934-hydroxythreonine-4-phosphate dehydrogenase
Candidatus Solibacter usitatusAcid_03904-hydroxythreonine-4-phosphate dehydrogenase
Caulobacter segnis15250Cseg_22934-hydroxythreonine-4-phosphate dehydrogenase
Cellulophaga lytica14961Celly_12714-hydroxythreonine-4-phosphate dehydrogenase
Chitinispirillum alkaliphilumCHISP_07544-hydroxythreonine-4-phosphate dehydrogenase
Chitinivibrio alkaliphilusCALK_03064-hydroxythreonine-4-phosphate dehydrogenase
Chitinophaga pinensis15968Cpin_12374-hydroxythreonine-4-phosphate dehydrogenase
Chlorobaculum tepidum103806CT0591pyridoxal phosphate biosynthetic protein PdxA
Chlorobium limicola103803Clim_05414-hydroxythreonine-4-phosphate dehydrogenase
Chromobacterium violaceum12614CV_4231pyridoxal phosphate biosynthesis protein
Chryseobacterium gleum15054HMPREF0204_116204-hydroxythreonine-4-phosphate dehydrogenase
Chrysiogenes arsenatisP304_RS0103460hypothetical protein
Chthoniobacter flavusCfE428DRAFT_23484-hydroxythreonine-4-phosphate dehydrogenase
Clostridium clariflavum101661Clocl_26534-hydroxythreonine-4-phosphate dehydrogenase
Clostridium thermocellum103400Cthe_09284-hydroxythreonine-4-phosphate dehydrogenase
Congregibacter litoralis104960KT71_021924-hydroxythreonine-4-phosphate dehydrogenase
Coraliomargarita akajimensisCaka_08634-hydroxythreonine-4-phosphate dehydrogenase
Cupriavidus metallidurans102507Rmet_04384-hydroxy-L-threonine phosphate dehydrogenase, NAD-dependent
Rmet_25904-hydroxythreonine-4-phosphate dehydrogenase (4- (phosphohydroxy)-L-threonine dehydrogenase)
Cytophaga hutchinsonii15051CHU_16274-hydroxythreonine-4-phosphate dehydrogenase
Deferribacter desulfuricans101012DEFDS_18754-hydroxythreonine-4-phosphate dehydrogenase
Desulfovibrio magneticus104933DMR_228504-hydroxythreonine-4-phosphate dehydrogenase
Desulfovibrio vulgaris subsp. vulgaris104121DVU_2241pyridoxal phosphate biosynthetic protein PdxA
Edwardsiella tarda105688ET1_10_004304-hydroxythreonine-4-phosphate dehydrogenase
Elusimicrobium minutumEmin_14824-Hydroxythreonine-4-phosphate dehydrogenase
Endomicrobium proavitumEpro_12074-hydroxythreonine-4-phosphate dehydrogenase
Enterobacter aerogenes13534EAE_110304-hydroxythreonine-4-phosphate dehydrogenase
EAE_186054-hydroxythreonine-4-phosphate dehydrogenase 2
Enterobacter cloacae subsp. cloacae13535ECL_008504-hydroxythreonine-4-phosphate dehydrogenase
ECL_019964-hydroxythreonine-4-phosphate dehydrogenase 2
Enterobacter hormaechei105718HMPREF9086_17794-hydroxythreonine-4-phosphate dehydrogenase
Enterococcus pallens100697I588_018664-hydroxythreonine-4-phosphate dehydrogenase
Escherichia coli3972EcolC_36034-hydroxythreonine-4-phosphate dehydrogenase
Escherichia coli13500WFL_002604-hydroxythreonine-4-phosphate dehydrogenase
Escherichia coli12713Y75_00524-hydroxy-L-threonine phosphate dehydrogenase, NAD-dependent
Escherichia fergusonii102419EFER_00634-hydroxy-L-threonine phosphate dehydrogenase, NAD-dependent
Escherichia hermannii105704EH105704_02_030504-hydroxythreonine-4-phosphate dehydrogenase
EH105704_09_003704-hydroxythreonine-4-phosphate dehydrogenase
Fischerella sp.PCC9339_RS01300754-hydroxythreonine-4-phosphate dehydrogenase
Flavobacterium johnsoniae14942Fjoh_06494-hydroxythreonine-4-phosphate dehydrogenase
Flexibacter litoralis15988Fleli_05054-hydroxythreonine-4-phosphate dehydrogenase
Fluviicola taffensis106335Fluta_12474-hydroxythreonine-4-phosphate dehydrogenase
Fusobacterium nucleatum subsp. NucleatumFN0226Pyridoxal phosphate biosynthetic protein pdxA
Gemmata obscuriglobusGEMOB_RS231704-hydroxythreonine-4-phosphate dehydrogenase
Gemmatimonas aurantiaca100505GAU_21454-hydroxythreonine-4-phosphate dehydrogenase
Gloeobacter violaceusglr0970pyridoxal phosphate biosynthetic protein PdxA homolog
Gluconacetobacter hansenii14816GXY_013034-hydroxythreonine-4-phosphate dehydrogenase
Gluconobacter frateurii101659GfraN1_0101000031134-hydroxythreonine-4-phosphate dehydrogenase
Halomonas elongata15536HELO_10384-hydroxythreonine-4-phosphate dehydrogenase
HELO_34834-hydroxythreonine-4-phosphate dehydrogenase
Hylemonella gracilis14920HGR_159394-hydroxythreonine-4-phosphate dehydrogenase
Hyphomonas neptunium14232HNE_21514-hydroxythreonine-4-phosphate dehydrogenase
Ignavibacterium album101810IALB_16134-hydroxythreonine-4-phosphate dehydrogenase
Kineococcus radiotolerans101839Krad_43664-hydroxythreonine-4-phosphate dehydrogenase
Klebsiella pneumoniae14438KPR_0973
KPR_2164
KPR_2528
Klebsiella pneumoniae subsp. rhinoscleromatis105682HMPREF0484_3328pyridoxal phosphate biosynthetic protein PdxA
HMPREF0484_49774-hydroxythreonine-4-phosphate dehydrogenase
Kordia algicida100336KAOT1_16458putative 4-hydroxythreonine-4-phosphate dehydrogenase
Labrenzia aggregata16684SIAM614_112534-hydroxythreonine-4-phosphate dehydrogenase
SIAM614_178444-hydroxythreonine-4-phosphate dehydrogenase
Leadbetterella byssophila106382Lbys_07634-hydroxythreonine-4-phosphate dehydrogenase
Lentisphaera araneosaLNTAR_081414-hydroxythreonine-4-phosphate dehydrogenase
Limnochorda pilosa110152LIP_19094-hydroxythreonine-4-phosphate dehydrogenase
LIP_20994-hydroxythreonine-4-phosphate dehydrogenase
Magnetospirillum gryphiswaldense15271MGR_2848Pyridoxal phosphate biosynthetic protein PdxA
Magnetospirillum magnetotacticum15272Magn03010055COG1995: Pyridoxal phosphate biosynthesis protein
Marinomonas mediterranea103028Marme_10194-hydroxythreonine-4-phosphate dehydrogenase
Mariprofundus ferrooxydansSPV1_134374-hydroxythreonine-4-phosphate dehydrogenase
Marivirga tractuosa15989Ftrac_31964-hydroxythreonine-4-phosphate dehydrogenase
Methylacidiphilum infernorumMinf_0291Pyridoxal phosphate biosynthesis protein
Methylobacterium radiotolerans15690Mrad2831_05534-hydroxythreonine-4-phosphate dehydrogenase
Mrad2831_46424-hydroxythreonine-4-phosphate dehydrogenase
Microscilla marina16560M23134_034854-hydroxythreonine-4-phosphate dehydrogenase
Myroides odoratus14945Myrod_19204-hydroxythreonine-4-phosphate dehydrogenase
Niastella koreensis106392Niako_35984-hydroxythreonine-4-phosphate dehydrogenase
Niako_69244-hydroxythreonine-4-phosphate dehydrogenase
Nitrosomonas europaea14298NE08834-hydroxythreonine-4-phosphate dehydrogenase
Nitrospina gracilisNITGR_1000474-hydroxythreonine-4-phosphate dehydrogenase
Nocardiopsis dassonvillei14626Ndas_24534-hydroxythreonine-4-phosphate dehydrogenase
Ndas_26244-hydroxythreonine-4-phosphate dehydrogenase
Nostoc sp.alr4755 pdxA gene product
Ochrobactrum anthropi15819Oant_26054-hydroxythreonine-4-phosphate dehydrogenase
Oant_30974-hydroxythreonine-4-phosphate dehydrogenase
Ochrobactrum intermedium15820OINT_10007174-hydroxythreonine-4-phosphate dehydrogenase
OINT_40000954-hydroxythreonine-4-phosphate dehydrogenase
Oscillibacter valericigenes101213OBV_345204-hydroxythreonine-4-phosphate dehydrogenase
OBV_438104-hydroxythreonine-4-phosphate dehydrogenase
Paenibacillus peoriae15541PpeoK3_0101000150264-hydroxythreonine-4-phosphate dehydrogenase
Pedobacter heparinus12017Phep_05234-hydroxythreonine-4-phosphate dehydrogenase
Phep_38134-hydroxythreonine-4-phosphate dehydrogenase
Pedobacter saltans100064Pedsa_03294-hydroxythreonine-4-phosphate dehydrogenase
Pedsa_33034-hydroxythreonine-4-phosphate dehydrogenase
Pelobacter carbinolicus103641Pcar_00884-hydroxythreonine-4-phosphate dehydrogenase
Pelobacter propionicus103807Ppro_32294-hydroxythreonine-4-phosphate dehydrogenase
Phaeobacter gallaeciensis16654PGA1_c198504-hydroxythreonine-4-phosphate dehydrogenase PdxA
Photobacterium damselae subsp. damselae corrig.15633VDA_0029764-hydroxythreonine-4-phosphate dehydrogenase
Phycisphaera mikurensis102666PSMK_118604-hydroxythreonine-4-phosphate dehydrogenase
Planctomyces brasiliensis103401Plabr_25164-hydroxythreonine-4-phosphate dehydrogenase
Prochlorococcus marinus subsp. marinusPro_0028Pyridoxal phosphate biosynthesis protein
Proteus mirabilis105697HMPREF0693_25474-hydroxythreonine-4-phosphate dehydrogenase
Providencia alcalifaciens105687PROVALCAL_022704-hydroxythreonine-4-phosphate dehydrogenase
Pseudomonas putida100650PP_0402pyridoxal phosphate biosynthetic protein PdxA
Pseudomonas stutzeri14165PSTAB_06224-hydroxythreonine-4-phosphate dehydrogenase
Rahnella aquatilis105701Rahaq2_38604-hydroxythreonine-4-phosphate dehydrogenase
Rhizobium etli15573RHE_CH014504-hydroxythreonine-4-phosphate dehydrogenase protein
RHE_PB000284-hydroxythreonine-4-phosphate dehydrogenase protein
Rhizobium sp.101917NGR_b06680predicted Pyridoxal phosphate biosynthetic protein PdxA
NGR_b171604-hydroxythreonine-4-phosphate dehydrogenase 2
NGR_b211304-hydroxythreonine-4-phosphate dehydrogenase 3
NGR_c089904-hydroxythreonine-4-phosphate dehydrogenase 1
Rhizobium tropici15247RTCIAT899_CH061604-hydroxythreonine-4-phosphate dehydrogenase
RTCIAT899_CH159154-hydroxythreonine-4-phosphate dehydrogenase
Rhodobacter capsulatus16581RCAP_rcc026904-hydroxythreonine-4-phosphate dehydrogenase
Rhodobacter sphaeroides12203RSP_2904Putative4-hydroxythreonine-4-phosphate dehydrogenase 1
RSP_34064-hydroxythreonine-4-phosphate dehydrogenase 2
Rhodococcus erythropolis100887RER_05270probable 4-hydroxythreonine-4-phosphate dehydrogenase
Rhodococcus opacus108011ROP_471104-hydroxythreonine-4-phosphate dehydrogenase
Roseobacter denitrificans15277RD1_31234-hydroxythreonine-4-phosphate dehydrogenase
Roseobacter litoralis15278RLO149_c0235204-hydroxythreonine-4-phosphate dehydrogenase PdxA
Rubrobacter xylanophilus100952Rxyl_29884-hydroxythreonine-4-phosphate dehydrogenase
Saccharomonospora azurea14651SacazDRAFT_044244-hydroxythreonine-4-phosphate dehydrogenase
Saccharomonospora cyanea14841SaccyDRAFT_17714-hydroxythreonine-4-phosphate dehydrogenase
Saccharomonospora glauca14831SacglDRAFT_016064-hydroxythreonine-4-phosphate dehydrogenase
Saccharopolyspora erythraea13426SACE_34604-hydroxythreonine-4-phosphate dehydrogenase
SACE_45484-hydroxythreonine-4-phosphate dehydrogenase
Salinibacter ruberSRU_10064-hydroxythreonine-4-phosphate dehydrogenase
Serratia odorifera102598HMPREF0758_05524-hydroxythreonine-4-phosphate dehydrogenase
HMPREF0758_21454-hydroxythreonine-4-phosphate dehydrogenase
Shimwellia blattae105725EB105725_11_007304-hydroxythreonine-4-phosphate dehydrogenase
EB105725_11_013804-hydroxythreonine-4-phosphate dehydrogenase
Solitalea canadensis15130Solca_32334-hydroxythreonine-4-phosphate dehydrogenase
Sphingobacterium spiritivorum14948HMPREF0766_111174-hydroxythreonine-4-phosphate dehydrogenase
Sphingobium japonicum101211SJA_C1-255504-hydroxythreonine-4-phosphate dehydrogenase
Sphingobium sp.103272SLG_148904-hydroxythreonine-4-phosphate dehydrogenase
Sphingomonas echinoides15742SechA1_0101000015364-hydroxythreonine-4-phosphate dehydrogenase
Sphingomonas wittichii105917Swit_04094-hydroxythreonine-4-phosphate dehydrogenase
Stackebrandtia nassauensis102104Snas_32644-hydroxythreonine-4-phosphate dehydrogenase
Starkeya novella14993Snov_10924-hydroxythreonine-4-phosphate dehydrogenase
Snov_16044-hydroxythreonine-4-phosphate dehydrogenase
Snov_35784-hydroxythreonine-4-phosphate dehydrogenase
Snov_36444-hydroxythreonine-4-phosphate dehydrogenase
Streptomyces purpureus13925STRPU_17_080704-hydroxythreonine-4-phosphate dehydrogenase
Synechococcus elongatusSynpcc7942_08044-hydroxythreonine-4-phosphate dehydrogenase
Synechocystis sp.sll0660pyridoxal phosphate biosynthetic protein; PdxA
Thauera linaloolentis102519C666_018204-hydroxythreonine-4-phosphate dehydrogenase
Thermodesulfobacterium communeHL41_011654-hydroxythreonine-4-phosphate dehydrogenase
Thermodesulfovibrio yellowstoniiTHEYE_A11484-hydroxythreonine-4-phosphate dehydrogenase
Vibrio alginolyticus15630N646_2526pyridoxal phosphate biosynthetic protein PdxA
Vibrio ichthyoenteri15847VII00023_170914-hydroxythreonine-4-phosphate dehydrogenase
Vibrio metschnikovii103153VIB_0020904-hydroxythreonine-4-phosphate dehydrogenase
Vibrio orientalis15638VIOR3934_097954-hydroxythreonine-4-phosphate dehydrogenase
Vibrio tubiashii15644VITU9109_256754-hydroxythreonine-4-phosphate dehydrogenase
Vibrio vulnificus15645B736_105404-hydroxythreonine-4-phosphate dehydrogenase
Weeksella virosa16016Weevi_14484-hydroxythreonine-4-phosphate dehydrogenase
Xenococcus sp.Xen7305DRAFT_000030704-hydroxythreonine-4-phosphate dehydrogenase
Yersinia bercovieri105717yberc0001_95604-hydroxythreonine-4-phosphate dehydrogenase
Yersinia rohdei105715yrohd0001_55504-hydroxythreonine-4-phosphate dehydrogenase
Zymomonas mobilis subsp. pomaceae13757Zymop_00274-hydroxythreonine-4-phosphate dehydrogenase