English site

遺伝子 : Aspartate 1-decarboxylase (PAND)

遺伝子情報

ID NRULE_0115
遺伝子ID PAND
作成日 2013/01/21
タンパク質名
Protein name
Full
Aspartate 1-decarboxylase
EC
EC 4.1.1.11
Synonym
Full
Aspartate alpha-decarboxylase
遺伝子名 panD
遺伝子条件 HAMAP; MF_00446; hit=1
参照
Gene Ontology
GO
GO:0005737, C:cytoplasm, IEA:UniProtKB-SubCell
GO:0004068, F:aspartate 1-decarboxylase activity, IEA:EC
GO:0006523, P:alanine biosynthetic process, IEA:InterPro
GO:0015940, P:pantothenate biosynthetic process, IEA:UniProtKB-UniPathway
GO:0016540, P:protein autoprocessing, IDA:EcoCyc
Phylogenomic databases
HOGENOM
HOG000221007, -
KO
K01579, -
ProtClustDB
PRK05449, -
Enzyme and pathway databases
BioCyc
MetaCyc:ASPDECARBOX-MONOMER, -
BRENDA
4.1.1.11, 2026
UniPathway
UPA00028, UER00002
Family and domain databases
HAMAP
MF_00446, PanD, 1, -
InterPro
IPR009010, Asp_de-COase-like_fold
IPR003190, Asp_decarbox
Pfam
PF02261, Asp_decarbox, 1
PIRSF
PIRSF006246, Asp_decarbox, 1
ProDom
PD009294, Asp_decarbox, 1
TIGRFAMs
TIGR00223, panD, 1
配列の特徴
P0A790 Escherichia coli (strain K12).
ACT_SITE25Schiff-base intermediate with substrate; via pyruvic acid.
ACT_SITE58Proton donor.
BINDING57Substrate (By similarity).
MOD_RES25Pyruvic acid (Ser).
注釈
Function
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Catalytic activity
L-aspartate = beta-alanine + CO(2)
Cofactor
Pyruvoyl group
Pathway
Cofactor biosynthesis; (R)-pantothenate biosynthesis; beta-alanine from L-aspartate: step 1/1
Subunit structure
Heterooctamer of four alpha and four beta subunits
Subcellular location
Cytoplasm
Sequence similarities
Belongs to the PanD family
参考文献
P0A790 Escherichia coli (strain K12).
8837478
Characterization and sequence of the Escherichia coli panBCD gene cluster. (FEMS Microbiol Lett. 1996)
6767707
Beta-alanine synthesis in Escherichia coli. (J Bacteriol. 1980)
12240302
Identification of Tyr58 as the proton donor in the aspartate-alpha-decarboxylase reaction. (Chem Commun (Camb). 2001)



関与する機能

機能名
(R)-pantothenate biosynthesis

該当CDS

データダウンロード
学名 NBRC番号 CDS タンパク質名
Acaricomes phytoseiuli107788C501_08980aspartate decarboxylase
Acaryochloris marina102967AM1_2358aspartate 1-decarboxylase
Acidithiobacillus ferrooxidansLferr_2688aspartate 1-decarboxylase
Acinetobacter radioresistens102413ACRAD_14_00710aspartate 1-decarboxylase
Acinetobacter sp.100985ACT4_021_01990aspartate 1-decarboxylase
Actinoalloteichus cyanogriseus14455G443_06_00280aspartate 1-decarboxylase
G443_07_00230aspartate 1-decarboxylase
Actinoalloteichus spitiensis102582ACTIDRAF_19705hypothetical protein
Actinomadura atramentaria14695G339_20895aspartate decarboxylase
Actinoplanes missouriensis102363AMIS_77760putative L-aspartate 1-decarboxylase
Actinopolyspora iraqiensis103187ACTIR_428_00020aspartate 1-decarboxylase
Actinosynnema mirum14064Amir_0326aspartate 1-decarboxylase
Alicyclobacillus acidocaldarius subsp. acidocaldarius15652Aaci_0298aspartate 1-decarboxylase
Aaci_1959aspartate 1-decarboxylase
Amycolatopsis azurea14573C791_0704Aspartate 1-decarboxylase
Amycolatopsis mediterranei13415RAM_25625aspartate alpha-decarboxylase
RAM_44830aspartate 1-decarboxylase
Anoxybacillus flavithermus15317Aflv_1128Aspartate 1-decarboxylase
Aquifex aeolicusaq_476aspartate 1-decarboxylase
Aquimarina agarilytica107695AagaZ_020100013824aspartate alpha-decarboxylase
Arcanobacterium haemolyticum15585Arch_0260aspartate 1-decarboxylase
Arthrobacter globiformis12137ARGLB_073_01610aspartate 1-decarboxylase
Austwickia chelonae105200AUCHE_05_00860aspartate 1-decarboxylase
Bacillus amyloliquefaciens15535BAMF_2141aspartate 1-decarboxylase
Bacillus atrophaeus13721BATRMS_17_01890aspartate alpha-decarboxylase
Bacillus cereus15305BC_1542Aspartate 1-decarboxylase
Bacillus licheniformis12200BL02750aspartate 1-decarboxylase
Bacillus licheniformis12195BLi02376aspartate 1-decarboxylase PanD
Bacillus mojavensis15718GYU_35_00030aspartate alpha-decarboxylase
Bacillus mycoides101228bmyco0001_14040Aspartate 1-decarboxylase alpha chain
Bacillus pseudomycoides101232bpmyx0001_14180Aspartate 1-decarboxylase alpha chain
Bacillus psychrosaccharolyticus101233WYK_249_00350aspartate alpha-decarboxylase
Bacillus pumilus12092BAT_2047aspartate 1-decarboxylase
Bacillus subtilis3134BSU6633_18098aspartate alpha-decarboxylase
Bacillus subtilis subsp. subtilis13719BSU22410aspartate 1-decarboxylase
Bacillus thuringiensis101235bthur0008_14150Aspartate 1-decarboxylase alpha chain
Bacillus vallismortis101236BvalD_010100015635aspartate alpha-decarboxylase
Bacteroides vulgatus14291BVU_2899aspartate 1-decarboxylase precursor
Balneola vulgarisB155_RS13055aspartate 1-decarboxylase
Bergeyella zoohelcum16014HMPREF9699_00859aspartate 1-decarboxylase
Bradyrhizobium diazoefficiens14792blr2096aspartate 1-decarboxylase precursor
Brevibacillus brevis100599BBR47_25040aspartate 1-decarboxylase precursor
BBR47_30880aspartate 1-decarboxylase precursor
Brevundimonas subvibrioides16000Bresu_2790aspartate 1-decarboxylase
Calditerrivibrio nitroreducens101217Calni_1116L-aspartate 1-decarboxylase
Catenulispora acidiphila102108Caci_8382aspartate 1-decarboxylase
Caulobacter segnis15250Cseg_2946aspartate 1-decarboxylase
Cellulomonas fimi15513Celf_0572aspartate 1-decarboxylase
Cellulomonas flavigena3775Cfla_0636aspartate 1-decarboxylase
Cellulophaga lytica14961Celly_1052Aspartate 1-decarboxylase
Chitinispirillum alkaliphilumCHISP_2253Aspartate 1-decarboxylase
Chitinivibrio alkaliphilusCALK_0663aspartate 1-decarboxylase
Chitinophaga pinensis15968Cpin_3688aspartate 1-decarboxylase
Chloracidobacterium thermophilum BCabther_A0195L-aspartate-alpha-decarboxylase
Chlorobaculum tepidum103806CT0252aspartate 1-decarboxylase
Chlorobium limicola103803Clim_0310aspartate 1-decarboxylase
Chromobacterium violaceum12614CV_1637aspartate 1-decarboxylase
Chryseobacterium gleum15054HMPREF0204_12049aspartate 1-decarboxylase
Chrysiogenes arsenatisP304_RS0111140L-aspartate 1-decarboxylase
Chthoniobacter flavusCfE428DRAFT_1579aspartate 1-decarboxylase
Chthonomonas calidiroseaCCALI_02692L-aspartate 1-decarboxylase
Clostridium acetobutylicum13948CA_C2916Aspartate 1-decarboxylase
Clostridium clariflavum101661Clocl_2124L-aspartate 1-decarboxylase
Clostridium kluyveri12016CKR_1508hypothetical protein
Clostridium thermocellum103400Cthe_0900aspartate 1-decarboxylase
Conexibacter woesei100937Cwoe_2890aspartate 1-decarboxylase
Coraliomargarita akajimensisCaka_2406aspartate 1-decarboxylase
Corynebacterium callunae15359H924_00755aspartate alpha-decarboxylase
Corynebacterium efficiens100395CE0135aspartate 1-decarboxylase
Corynebacterium glutamicum12168Cgl0135Aspartate 1-decarboxylase
Corynebacterium glutamicum12153KIQ_15058aspartate alpha-decarboxylase
Corynebacterium terpenotabidum14764A606_01990aspartate alpha-decarboxylase
Cystobacter fuscus100088D187_000930Aspartate 1-decarboxylase
Cytophaga hutchinsonii15051CHU_3834aspartate 1-decarboxylase
Deferribacter desulfuricans101012DEFDS_0845aspartate 1-decarboxylase
Dehalococcoides mccartyiDehaBAV1_0726aspartate 1-decarboxylase
Deinococcus proteolyticus101906Deipr_0757Aspartate 1-decarboxylase
Edwardsiella tarda105688ET1_10_01190aspartate 1-decarboxylase
Endomicrobium proavitumEpro_0414Aspartate 1-decarboxylase
Enterobacter aerogenes13534EAE_11485aspartate alpha-decarboxylase
Enterobacter cloacae subsp. cloacae13535ECL_00943aspartate alpha-decarboxylase
Enterobacter hormaechei105718HMPREF9086_1690aspartate 1-decarboxylase
Escherichia coli3972EcolC_3528aspartate 1-decarboxylase
Escherichia coli13500WFL_00630aspartate alpha-decarboxylase
Escherichia coli12713Y75_0128aspartate 1-decarboxylase
Escherichia fergusonii102419EFER_0152aspartate 1-decarboxylase
Escherichia hermannii105704EH105704_09_00510aspartate 1-decarboxylase
Fibrobacter succinogenesFisuc_0456aspartate 1-decarboxylase
Fimbriimonas ginsengisoliOP10G_3944aspartate 1-decarboxylase
Fischerella sp.PCC9339_RS0115885aspartate decarboxylase
Flavobacterium johnsoniae14942Fjoh_0826aspartate 1-decarboxylase
Flexibacter litoralis15988Fleli_3517L-aspartate 1-decarboxylase
Fluviicola taffensis106335Fluta_0891L-aspartate 1-decarboxylase
Frateuria aurantia3245Fraau_2543L-aspartate-alpha-decarboxylase
Gemmata obscuriglobusGEMOB_RS05550aspartate decarboxylase
Geodermatophilus obscurus13315Gobs_0633aspartate 1-decarboxylase
Gloeobacter violaceusglr2845L-aspartate-alpha-decarboxylase
glr4228aspartate 1-decarboxylase
Gordonia aichiensis108223GOACH_01_01800aspartate 1-decarboxylase
Gordonia alkanivorans16433GOALK_015_00130aspartate 1-decarboxylase
Gordonia amarae15530GOAMR_72_00290aspartate 1-decarboxylase
Gordonia amicalis100051GOAMI_36_00090aspartate 1-decarboxylase
Gordonia araii100433GOARA_053_00090aspartate 1-decarboxylase
Gordonia bronchialis16047Gbro_4006aspartate 1-decarboxylase
Gordonia effusa100432GOEFS_047_00180aspartate 1-decarboxylase
GOEFS_091_00640aspartate 1-decarboxylase
Gordonia hirsuta16056GOHSU_27_00740aspartate 1-decarboxylase
Gordonia namibiensis108229GONAM_11_02220aspartate 1-decarboxylase
Gordonia otitidis100426GOOTI_012_00160aspartate 1-decarboxylase
Gordonia polyisoprenivorans16320GOPIP_077_01470aspartate 1-decarboxylase
Gordonia rhizosphera16068GORHZ_058_00060aspartate 1-decarboxylase
Gordonia rubripertincta101908GORBP_059_00430aspartate 1-decarboxylase
Gordonia sihwensis108236GSI01S_12_00180aspartate 1-decarboxylase
Gordonia soli108243GS4_11_03940aspartate 1-decarboxylase
Gordonia sputi100414GOSPT_103_00510aspartate 1-decarboxylase
Gordonia terrae100016GOTRE_054_00690aspartate 1-decarboxylase
Halobacillus halophilus102448HBHAL_3255aspartate 1-decarboxylase
Halomonas elongata15536HELO_4130aspartate 1-decarboxylase
Herpetosiphon aurantiacusHaur_0386aspartate 1-decarboxylase
Holophaga foetidaHOLFODRAFT_RS0213305aspartate decarboxylase
Hyphomonas neptunium14232HNE_1379aspartate 1-decarboxylase
Ignavibacterium album101810IALB_0059Aspartate 1-decarboxylase
Intrasporangium calvum12989Intca_0612L-aspartate 1-decarboxylase
Jonesia denitrificans15587Jden_2095aspartate 1-decarboxylase
Kitasatospora setae14216KSE_34000putative L-aspartate 1-decarboxylase
KSE_70480putative L-aspartate 1-decarboxylase
Klebsiella pneumoniae14438KPR_1069
Klebsiella pneumoniae subsp. rhinoscleromatis105682HMPREF0484_4876aspartate 1-decarboxylase
Kocuria rhizophila103217KRH_03780aspartate 1-decarboxylase precursor
Kordia algicida100336KAOT1_15007aspartate 1-decarboxylase precursor
Kribbella flavida14399Kfla_1213aspartate 1-decarboxylase
Ktedonobacter racemiferKrac_8964aspartate 1-decarboxylase
Kyrpidia tusciae15312Btus_1692aspartate 1-decarboxylase
Leadbetterella byssophila106382Lbys_1175aspartate 1-decarboxylase
Lentisphaera araneosaLNTAR_20803aspartate 1-decarboxylase precursor
Leptospira interrogansLA_1729aspartate alpha-decarboxylase
Magnetospirillum gryphiswaldense15271MGR_2865Aspartate decarboxylase
Magnetospirillum magnetotacticum15272Magn03010092COG0853: Aspartate 1-decarboxylase
Marinomonas mediterranea103028Marme_1134Aspartate 1-decarboxylase
Mariprofundus ferrooxydansSPV1_02097aspartate 1-decarboxylase precursor
Marivirga tractuosa15989Ftrac_2049aspartate 1-decarboxylase
Micrococcus luteus3333Mlut_20270L-aspartate 1-decarboxylase
Micromonospora aurantiaca16155Micau_5857aspartate 1-decarboxylase
Microscilla marina16560M23134_04553aspartate 1-decarboxylase
Myroides odoratus14945Myrod_2001L-aspartate 1-decarboxylase
Nakamurella multipartita105858Namu_4391aspartate 1-decarboxylase
Niastella koreensis106392Niako_1524L-aspartate 1-decarboxylase
Nitriliruptor alkaliphilusNitalDRAFT_1541L-aspartate 1-decarboxylase
Nitrospina gracilisNITGR_590019Aspartate 1-decarboxylase
Nocardiopsis dassonvillei14626Ndas_1519aspartate 1-decarboxylase
Nostoc sp.all3569aspartate 1-decarboxylase
Oceanithermus profundus100410Ocepr_1248L-aspartate 1-decarboxylase
Paenibacillus alvei3343PAV_3c06400aspartate 1-decarboxylase PanD
Paenibacillus peoriae15541PpeoK3_010100005705aspartate 1-decarboxylase alpha chain
Paenibacillus polymyxa15309PPT_16380aspartate decarboxylase
Pedobacter heparinus12017Phep_0135aspartate 1-decarboxylase
Pedobacter saltans100064Pedsa_2816aspartate 1-decarboxylase
Pelobacter carbinolicus103641Pcar_1828aspartate 1-decarboxylase
Pelobacter propionicus103807Ppro_3533aspartate 1-decarboxylase
Proteus mirabilis105697HMPREF0693_3257aspartate 1-decarboxylase
Providencia alcalifaciens105687PROVALCAL_02386aspartate 1-decarboxylase
Pseudomonas stutzeri14165PSTAB_3345aspartate alpha-decarboxylase
Rahnella aquatilis105701Rahaq2_3758L-aspartate-alpha-decarboxylase
Renibacterium salmoninarum15589RSal33209_2226aspartate 1-decarboxylase
Rhizobium sp.101917NGR_b12520aspartate 1-decarboxylase precursor
Rhodococcus erythropolis100887RER_06340aspartate 1-decarboxylase
Rhodococcus opacus108011ROP_43320aspartate 1-decarboxylase
Saccharomonospora azurea14651SacazDRAFT_02318L-aspartate-alpha-decarboxylase
Saccharomonospora cyanea14841SaccyDRAFT_4686L-aspartate-alpha-decarboxylase
Saccharomonospora glauca14831SacglDRAFT_03944L-aspartate-alpha-decarboxylase
Saccharomonospora viridis12207Svir_35540L-aspartate 1-decarboxylase
Saccharopolyspora erythraea13426SACE_0407aspartate 1-decarboxylase precursor
Saccharopolyspora spinosa15153SspiN1_010100021168aspartate decarboxylase
Saccharothrix espanaensis15066BN6_03650Aspartate 1-decarboxylase
BN6_58900Aspartate 1-decarboxylase
Salinibacter ruberSRU_1412aspartate 1-decarboxylase
Salinispora arenicola105043Q5S_3003_00010aspartate 1-decarboxylase
Salinispora tropica105044Strop_4282L-aspartate 1-decarboxylase
Sanguibacter keddieii16158Sked_32000L-aspartate 1-decarboxylase
Selenomonas ruminantium subsp. lactilytica103574SELR_01990putative aspartate 1-decarboxylase
Serratia odorifera102598HMPREF0758_2156aspartate 1-decarboxylase
Shimwellia blattae105725EB105725_11_00630aspartate 1-decarboxylase
Solitalea canadensis15130Solca_3494L-aspartate-alpha-decarboxylase
Sphingobacterium spiritivorum14948HMPREF0766_11163aspartate 1-decarboxylase
Sporichthya polymorpha12702Spopo_30_20180Aspartate 1-decarboxylase
Stackebrandtia nassauensis102104Snas_0089aspartate 1-decarboxylase
Snas_0195aspartate 1-decarboxylase
Staphylococcus epidermidis12993SE_2139aspartate 1-decarboxylase
Staphylococcus saprophyticus subsp. saprophyticus102446SSP0933truncated aspartate 1-decarboxylase precursor
Streptomyces avermitilis14893SAV7245putative L-aspartate 1-decarboxylase
Streptomyces cattleya14057SCAT_p0659aspartate 1-decarboxylase
Streptomyces clavuligerus13307SCLAV_p0287L-aspartate 1-decarboxylase
Streptomyces ghanaensis15414SSFG_00761aspartate alpha-decarboxylase
Streptomyces mobaraensis13819H340_28777aspartate 1-decarboxylase
H340_29761Aspartate 1-decarboxylase
Streptomyces pristinaespiralis13074SSDG_02625aspartate 1-decarboxylase
Streptomyces purpureus13925STRPU_17_02530Aspartate 1-decarboxylase
Streptomyces sviceus13980SSEG_05564aspartate 1-decarboxylase
Streptomyces venezuelae13096SVEN_6802Aspartate 1-decarboxylase
Streptosporangium roseum3776Sros_9159Aspartate 1-decarboxylase
Synechocystis sp.sll0892aspartate 1-decarboxylase
Thermanaerovibrio acidaminovoransTaci_0465aspartate 1-decarboxylase
Thermobispora bispora14880Tbis_3425aspartate 1-decarboxylase
Thermodesulfobacterium communeHL41_09055aspartate decarboxylase
Thermodesulfobium narugense100082Thena_0443Aspartate 1-decarboxylase
Thermodesulfovibrio yellowstoniiTHEYE_A1874aspartate 1-decarboxylase
Thermomonospora curvata15933Tcur_0364aspartate 1-decarboxylase
Tcur_4486aspartate 1-decarboxylase
Thermoproteus neutrophilus100436Tneu_0357aspartate 1-decarboxylase
Thermotoga lettingae107922Tlet_0872aspartate 1-decarboxylase
Thermotoga maritima100826TM_0939aspartate 1-decarboxylase
Thermotoga naphthophila104846Tnap_1805aspartate 1-decarboxylase
Thermotoga neapolitana107923CTN_1637Aspartate 1-decarboxylase precursor
Thermotoga petrophila104847Tpet_1803L-aspartate 1-decarboxylase
Thermotoga thermarum107925Theth_1433L-aspartate 1-decarboxylase
Thermus thermophilus101084TTHA0606aspartate 1-decarboxylase
Thermus thermophilus101085TT_C0241aspartate 1-decarboxylase
Tsukamurella paurometabola16120Tpau_0568aspartate 1-decarboxylase
Weeksella virosa16016Weevi_0983Aspartate 1-decarboxylase
Xenococcus sp.Xen7305DRAFT_00023200L-aspartate 1-decarboxylase
Xylanimonas cellulosilytica107835Xcel_1645aspartate 1-decarboxylase
Yersinia bercovieri105717yberc0001_11400Aspartate 1-decarboxylase alpha chain
Yersinia rohdei105715yrohd0001_3630Aspartate 1-decarboxylase alpha chain