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遺伝子 : Biotin synthase (BIOB)

遺伝子情報

ID NRULE_0185
遺伝子ID BIOB
作成日 2013/03/27
タンパク質名
Protein name
Full
Biotin synthase
EC
EC 2.8.1.6
遺伝子名 bioB
遺伝子条件 HAMAP; MF_01694; hit=1
OR
TIGRFAMs; TIGR00433; hit=1
参照
Gene Ontology
GO
GO:0051537, F:2 iron, 2 sulfur cluster binding, IDA:EcoCyc
GO:0051539, F:4 iron, 4 sulfur cluster binding, IDA:EcoCyc
GO:0004076, F:biotin synthase activity, IDA:EcoCyc
GO:0046872, F:metal ion binding, IEA:UniProtKB-KW
GO:0009102, P:biotin biosynthetic process, IMP:EcoCyc
Phylogenomic databases
eggNOG
COG0502, -
HOGENOM
HOG000239957, -
KO
K01012, -
ProtClustDB
PRK15108, -
Enzyme and pathway databases
BioCyc
MetaCyc:BIOTIN-SYN-MONOMER, -
UniPathway
UPA00078, UER00162
Family and domain databases
HAMAP
MF_01694, BioB, 1, -
InterPro
IPR013785, Aldolase_TIM
IPR010722, Biotin/thiamin_synth-assoc
IPR002684, Biotin_synth/BioAB
IPR024177, Biotin_synthase
IPR006638, Elp3/MiaB/NifB
IPR007197, rSAM
Pfam
PF06968, BATS, 1
PF04055, Radical_SAM, 1
PIRSF
PIRSF001619, Biotin_synth, 1
SMART
SM00876, BATS, 1
SM00729, Elp3, 1
TIGRFAMs
TIGR00433, bioB, 1
配列の特徴
P12996 Escherichia coli (strain K12).
METAL53Iron-sulfur 1 (4Fe-4S-S-AdoMet).
METAL57Iron-sulfur 1 (4Fe-4S-S-AdoMet).
METAL60Iron-sulfur 1 (4Fe-4S-S-AdoMet).
METAL97Iron-sulfur 2 (2Fe-2S).
METAL128Iron-sulfur 2 (2Fe-2S).
METAL188Iron-sulfur 2 (2Fe-2S).
METAL260Iron-sulfur 2 (2Fe-2S).
注釈
Function
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
Catalytic activity
Dethiobiotin + sulfur + 2 S-adenosyl-L- methionine = biotin + 2 L-methionine + 2 5'-deoxyadenosine
Cofactor
Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (By similarity)
Binds 1 2Fe-2S cluster. The cluster is coordinated with 3 cysteines and 1 arginine (By similarity)
Pathway
Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2
Subunit structure
Homodimer (By similarity)
Sequence similarities
Belongs to the radical SAM superfamily. Biotin synthase family
参考文献
P12996 Escherichia coli (strain K12).
3058702
The Escherichia coli biotin biosynthetic enzyme sequences predicted from the nucleotide sequence of the bio operon. (J Biol Chem. 1988)
19245793
Iron-sulfur cluster dynamics in biotin synthase: a new [2Fe-2S](1+) cluster. (Biochem Biophys Res Commun. 2009)



関与する機能

機能名
Biotin biosynthesis

該当CDS

データダウンロード
学名 NBRC番号 CDS タンパク質名
Acaryochloris marina102967AM1_1733biotin synthase
Acetobacter aceti14818AaceN1_010100007942biotin synthase
Acetobacter pasteurianus105190APA32_11590Biotin synthase
Acetobacter pasteurianus101655APT_0781biotin synthase
Acetobacter tropicalis101654ATPR_0916biotin synthase
Acidiphilium multivorum100883ACMV_21100biotin synthase
Acidithiobacillus ferrooxidansLferr_0436biotin synthase
Acinetobacter radioresistens102413ACRAD_20_00920biotin synthase
Acinetobacter sp.100985ACT4_028_01240biotin synthase
Actinoalloteichus cyanogriseus14455G443_05_02690biotin synthase
Actinoalloteichus spitiensis102582ACTIDRAF_08175biotin synthase
Actinomadura atramentaria14695G339_21970biotin synthase
Actinoplanes missouriensis102363AMIS_67990putative biotin synthase
Actinopolyspora iraqiensis103187ACTIR_271_00020biotin synthase
Actinosynnema mirum14064Amir_5738biotin synthase
Alicyclobacillus acidocaldarius subsp. acidocaldarius15652Aaci_2854biotin synthase
Alteromonas macleodii102226MASE_06275biotin synthase
Amycolatopsis azurea14573C791_1413Biotin synthase
C791_3408Biotin synthase
Amycolatopsis mediterranei13415RAM_11295biotin synthase
Anoxybacillus flavithermus15317Aflv_1376Biotin synthetase
Aquifex aeolicusaq_975biotin synthetase
Arthrobacter globiformis12137ARGLB_033_00120biotin synthase
Austwickia chelonae105200AUCHE_22_00460biotin synthase
Azorhizobium caulinodans14845AZC_0361biotin synthase
Bacillus amyloliquefaciens15535BAMF_1920biotin synthase
Bacillus atrophaeus13721BATRMS_05_00800biotin synthase
Bacillus cereus15305BC_4114Biotin synthase
Bacillus licheniformis12200BL00956biotin synthetase
Bacillus licheniformis12195BLi00770biotin synthase BioB
Bacillus mojavensis15718GYU_01_00450biotin synthase
Bacillus mycoides101228bmyco0001_37410Biotin synthase
Bacillus pseudomycoides101232bpmyx0001_35970Biotin synthase
Bacillus pumilus12092BAT_0217biotin synthase
Bacillus subtilis3134BSU6633_12887biotin synthase
Bacillus subtilis subsp. subtilis13719BSU30200biotin synthase
Bacillus thuringiensis101235bthur0008_39070Biotin synthase
Bacillus vallismortis101236BvalD_010100010255biotin synthase
Balneola vulgarisB155_RS0101735biotin synthase BioB
Bergeyella zoohelcum16014HMPREF9699_01915biotin synthase
Bradyrhizobium diazoefficiens14792blr2095biotin synthetase
Brevibacillus brevis100599BBR47_54620biotin synthase
Brevibacterium linens12170BlinB_010200018625biotin synthase
BlinB_010200019320biotin synthase
Brevundimonas subvibrioides16000Bresu_0036biotin synthase
Calditerrivibrio nitroreducens101217Calni_1516biotin synthase
Candidatus Nitrosopumilus sp.NSED_04535biotin synthase
Catenulispora acidiphila102108Caci_4597biotin synthase
Caci_7724biotin synthase
Caulobacter segnis15250Cseg_0162biotin synthase
Cellulophaga lytica14961Celly_1032biotin synthase
Cenarchaeum symbiosumCENSYa_0981biotin synthase
Chitinispirillum alkaliphilumCHISP_2150Biotin synthase
Chitinivibrio alkaliphilusCALK_2040biotin synthase
Chitinophaga pinensis15968Cpin_4622biotin synthase
Chloracidobacterium thermophilum BCabther_A1844biotin synthetase
Chlorobaculum tepidum103806CT0052biotin synthetase
Chlorobium limicola103803Clim_2430Biotin synthase
Chromobacterium violaceum12614CV_4381biotin synthase
Chryseobacterium gleum15054HMPREF0204_13792biotin synthase
Chrysiogenes arsenatisP304_RS15605biotin synthase BioB
Chthoniobacter flavusCfE428DRAFT_2352biotin synthase
Clostridium acetobutylicum13948CA_C0210Biotine synthase (gene bioB)
Clostridium clariflavum101661Clocl_0758biotin synthase
Clostridium kluyveri12016CKR_1576hypothetical protein
Clostridium thermocellum103400Cthe_0020biotin synthase
Conexibacter woesei100937Cwoe_0422biotin synthase
Cwoe_1571biotin synthase
Congregibacter litoralis104960KT71_03680biotin synthase
Coprobacillus sp.HMPREF1021_02310biotin synthase
Coraliomargarita akajimensisCaka_0765biotin synthase
Corynebacterium ammoniagenes12612HMPREF0281_00860biotin synthase
Corynebacterium callunae15359H924_00450biotin synthase
Corynebacterium efficiens100395CE0089biotin synthase
Corynebacterium glutamicum12168Cgl0072Biotin synthase and related enzymes
Corynebacterium glutamicum12153KIQ_05988biotin synthase
Corynebacterium matruchotii15360HMPREF0299_5173biotin synthase
Corynebacterium striatum15291HMPREF0308_2386biotin synthase
Corynebacterium terpenotabidum14764A606_04290biotin synthase
Cupriavidus metallidurans102507Rmet_0117biotin synthase slightly down RPM proteomics BL (0,72)down also RWV BL (0.68)
Cystobacter fuscus100088D187_000314Biotin synthase
Cytophaga hutchinsonii15051CHU_2466biotin synthase
Deferribacter desulfuricans101012DEFDS_1300biotin synthetase
Desulfovibrio magneticus104933DMR_33650putative biotin synthase
Desulfovibrio vulgaris subsp. vulgaris104121DVU_2558biotin synthase
Edwardsiella tarda105688ET1_08_00170biotin synthase
Endomicrobium proavitumEpro_1056Biotin synthase
Enterobacter aerogenes13534EAE_14445biotin synthase
Enterobacter cloacae subsp. cloacae13535ECL_02961biotin synthase
Enterobacter hormaechei105718HMPREF9086_1085biotin synthase
Enterococcus hirae3181EHR_07055biotin synthetase
Escherichia coli3972EcolC_2868biotin synthase
Escherichia coli13500WFL_04025biotin synthase
Escherichia coli12713Y75_0752biotin synthase
Escherichia fergusonii102419EFER_2338biotin synthase
Escherichia hermannii105704EH105704_23_00140biotin synthase
Fibrobacter succinogenesFisuc_0159Biotin synthase
Fisuc_0621biotin synthase
Fischerella sp.PCC9339_RS0110030biotin synthase
Flavobacterium johnsoniae14942Fjoh_0801biotin synthase
Flexibacter litoralis15988Fleli_1254biotin synthase
Fluviicola taffensis106335Fluta_2554Biotin synthase
Frateuria aurantia3245Fraau_0176biotin synthetase
Fusobacterium nucleatum subsp. NucleatumFN1000Biotin synthase
Gemmatimonas aurantiaca100505GAU_2843biotin synthase
Gloeobacter violaceusglr4328biotin synthase
Gluconacetobacter hansenii14816GXY_05753biotin synthase
Gluconobacter frateurii101659GfraN1_010100004924biotin synthase
Gordonia aichiensis108223GOACH_16_01200biotin synthase
Gordonia alkanivorans16433GOALK_084_00110biotin synthase
Gordonia amarae15530GOAMR_51_00040biotin synthase
Gordonia amicalis100051GOAMI_54_00230biotin synthase
Gordonia araii100433GOARA_052_00310biotin synthase
Gordonia bronchialis16047Gbro_2972biotin synthase
Gordonia effusa100432GOEFS_073_00960biotin synthase
Gordonia hirsuta16056GOHSU_02_00590biotin synthase
Gordonia namibiensis108229GONAM_46_00240biotin synthase
Gordonia otitidis100426GOOTI_099_00040biotin synthase
Gordonia polyisoprenivorans16320GOPIP_071_00310biotin synthase
Gordonia rhizosphera16068GORHZ_073_00140biotin synthase
Gordonia rubripertincta101908GORBP_068_00580biotin synthase
Gordonia sihwensis108236GSI01S_06_02070biotin synthase
Gordonia soli108243GS4_30_00630biotin synthase
Gordonia sputi100414GOSPT_058_00910biotin synthase
Gordonia terrae100016GOTRE_063_00240biotin synthase
Haloarcula vallismortis14741C437_16081biotin synthase
Halomonas elongata15536HELO_2170biotin synthase
Holophaga foetidaHOLFODRAFT_RS0202175biotin synthase
HOLFODRAFT_RS0203945biotin synthase
Hylemonella gracilis14920HGR_12047biotin synthase
Hyphomonas neptunium14232HNE_0048biotin synthase
Intrasporangium calvum12989Intca_2344biotin synthase
Kineosphaera limosa100340KILIM_012_00190biotin synthase
Kitasatospora setae14216KSE_71120putative biotin synthase
Klebsiella pneumoniae subsp. rhinoscleromatis105682HMPREF0484_1380biotin synthase
Kocuria rhizophila103217KRH_02440biotin synthase
Kordia algicida100336KAOT1_14877biotin synthase
Kribbella flavida14399Kfla_6017biotin synthase
Kyrpidia tusciae15312Btus_2595biotin synthase
Kytococcus sedentarius15357Ksed_26490biotin synthetase
Lentisphaera araneosaLNTAR_02372biotin synthase
Leptospira interrogansLA_2143biotin synthase
Magnetospirillum gryphiswaldense15271MGR_0588Biotin synthase and related enzymes
Magnetospirillum magnetotacticum15272Magn03007824COG0502: Biotin synthase and related enzymes
Marinomonas mediterranea103028Marme_3251Biotin synthase
Mariprofundus ferrooxydansSPV1_10311biotin synthase
Marivirga tractuosa15989Ftrac_1088biotin synthase
Methanocaldococcus jannaschii100440MJ_1296biotin synthetase (bioB)
Methanococcus maripaludis101832MMP1238TonB-dependent receptor protein:Biotin synthase
Methanococcus maripaludisMmarC5_0353biotin synthase
Methylacidiphilum infernorumMinf_1134Biotin synthase or related enzyme
Methylobacterium radiotolerans15690Mrad2831_5067biotin synthase
Micrococcus luteus3333Mlut_02190biotin synthase
Micromonospora aurantiaca16155Micau_1677biotin synthase
Microscilla marina16560M23134_00622biotin synthase
Mobilicoccus pelagius104925MOPEL_096_00270biotin synthase
Myroides odoratus14945Myrod_2879biotin synthase
Niastella koreensis106392Niako_3683biotin synthase
Nitriliruptor alkaliphilusNitalDRAFT_4966biotin synthase
Nitrosomonas europaea14298NE2300Biotin synthase
Nitrososphaera viennensisNVIE_004840biotin synthase
Nitrospina gracilisNITGR_310062Biotin synthase
Nocardiopsis dassonvillei14626Ndas_2103biotin synthase
Nostoc sp.alr1921biotin synthase
Ochrobactrum anthropi15819Oant_2823biotin synthase
Ochrobactrum intermedium15820OINT_2000090biotin synthase
Paenibacillus alvei3343PAV_1c04820biotin synthase BioB
Paenibacillus peoriae15541PpeoK3_010100017299biotin synthase
Paenibacillus polymyxa15309PPT_13270biotin synthase
Pedobacter heparinus12017Phep_2168biotin synthase
Pedobacter saltans100064Pedsa_3335biotin synthase
Pelobacter carbinolicus103641Pcar_1458biotin synthase
Pelobacter propionicus103807Ppro_1175biotin synthase
Phaeobacter gallaeciensis16654PGA1_c09120biotin synthase BioB
Photobacterium damselae subsp. damselae corrig.15633VDA_002298biotin synthase
Phycisphaera mikurensis102666PSMK_16230biotin synthase
Planctomyces brasiliensis103401Plabr_1086biotin synthase
Prochlorococcus marinus subsp. marinusPro_1102Biotin synthase
Propionibacterium acidipropionici12425PACID_10240Biotin synthase
Propionibacterium avidum15671HMPREF9153_0004biotin synthase
Proteus mirabilis105697HMPREF0693_1956biotin synthase
Providencia alcalifaciens105687PROVALCAL_03259biotin synthase
Pseudomonas putida100650PP_0362biotin synthetase
Pseudomonas stutzeri14165PSTAB_3817biotin synthase
Rahnella aquatilis105701Rahaq2_3124biotin synthetase
Renibacterium salmoninarum15589RSal33209_0557biotin synthase
Rhizobium sp.101917NGR_c25140biotin synthase BioB
Rhodobacter capsulatus16581RCAP_rcc03363biotin synthase
Rhodobacter sphaeroides12203RSP_1923Biotin synthase
Rhodococcus erythropolis100887RER_34880biotin synthase
Rhodococcus opacus108011ROP_07700biotin synthase
Saccharomonospora azurea14651SacazDRAFT_03942biotin synthetase
Saccharomonospora cyanea14841SaccyDRAFT_1258biotin synthetase
Saccharomonospora glauca14831SacglDRAFT_01189biotin synthetase
Saccharomonospora viridis12207Svir_10790biotin synthetase
Saccharopolyspora erythraea13426SACE_4683biotin synthase
Saccharopolyspora spinosa15153SspiN1_010100017356biotin synthase
Saccharothrix espanaensis15066BN6_68760Biotin synthase
Salinibacter ruberSRU_0756biotin synthase
Salinispora tropica105044Strop_1569biotin synthase
Selenomonas ruminantium subsp. lactilytica103574SELR_pSRC102540putative biotin synthase
Serratia odorifera102598HMPREF0758_4798biotin synthase
Shimwellia blattae105725EB105725_03_00250biotin synthase
Solitalea canadensis15130Solca_1841biotin synthetase
Sphingobacterium spiritivorum14948HMPREF0766_11940biotin synthase
Sphingobium japonicum101211SJA_C1-17030biotin synthetase
Sphingobium sp.103272SLG_24680biotin synthase
Sphingomonas echinoides15742SechA1_010100015447biotin synthase
Sphingomonas wittichii105917Swit_2890biotin synthase
Sporichthya polymorpha12702Spopo_31_09490Biotin synthase
Stackebrandtia nassauensis102104Snas_0469biotin synthase
Staphylococcus epidermidis12993SE_0234biotin synthase
Streptomyces avermitilis14893SAV7093putative biotin synthase
Streptomyces cattleya14057SCAT_0347biotin synthase
SCAT_p1299biotin synthase
Streptomyces clavuligerus13307SCLAV_0531Biotin synthase
Streptomyces ghanaensis15414SSFG_06093biotin synthase
Streptomyces mobaraensis13819H340_16526biotin synthase
Streptomyces pristinaespiralis13074SSDG_00910biotin synthase
Streptomyces purpureus13925STRPU_02_00690Biotin synthase
Streptomyces sviceus13980SSEG_09605biotin synthase
Streptomyces venezuelae13096SVEN_0844Biotin synthase
Streptosporangium roseum3776Sros_8311Biotin synthase
Synechococcus elongatusSynpcc7942_0419biotin synthase
Synechocystis sp.slr1364biotin synthetase
Thauera linaloolentis102519C666_07885biotin synthase
Thermanaerovibrio acidaminovoransTaci_0244Biotin synthase
Thermodesulfobium narugense100082Thena_1717Biotin synthase
Thermodesulfovibrio yellowstoniiTHEYE_A0809biotin synthase
Thermomonospora curvata15933Tcur_3698biotin synthase
Thermotoga neapolitana107923CTN_0289Biotin synthase
Thermotoga petrophila104847Tpet_0559biotin synthase
Thermus thermophilus101084TTHA0607biotin synthase (biotin synthetase)
Thermus thermophilus101085TT_C0242biotin synthase
Tsukamurella paurometabola16120Tpau_2002biotin synthase
Turicella otitidis106139HMPREF9719_00392biotin synthase 1
Vibrio alginolyticus15630N646_0164biotin synthase
Vibrio ichthyoenteri15847VII00023_15121biotin synthase
Vibrio metschnikovii103153VIB_001496biotin synthase
Vibrio orientalis15638VIOR3934_03222biotin synthase
Vibrio tubiashii15644VITU9109_16353biotin synthase
Xenococcus sp.Xen7305DRAFT_00043200biotin synthase
Zymomonas mobilis subsp. pomaceae13757Zymop_1127biotin synthase