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Rule : Dihydrofolate reductase (FOLA)

Rule Description

ID NRULE_0147
Rule name FOLA
Created 2013-02-20
Protein name
Protein name
Full
Dihydrofolate reductase
EC
EC 1.5.1.3
Gene name folA
Rule Trigger PFAM; PF00186; hit=1
Cross Reference
Gene Ontology
GO
GO:0004146, F:dihydrofolate reductase activity, IEA:EC
GO:0050661, F:NADP binding, IEA:InterPro
GO:0006545, P:glycine biosynthetic process, IEA:InterPro
GO:0009165, P:nucleotide biosynthetic process, IEA:InterPro
GO:0006730, P:one-carbon metabolic process, IEA:UniProtKB-KW
GO:0046677, P:response to antibiotic, IEA:UniProtKB-KW
GO:0031427, P:response to methotrexate, IEA:UniProtKB-KW
GO:0046654, P:tetrahydrofolate biosynthetic process, IEA:UniProtKB-UniPathway
Phylogenomic databases
KO
K00287, -
Family and domain databases
InterPro
IPR012259, DHFR
IPR017925, DHFR_CS
IPR001796, DHFR_dom
Pfam
PF00186, DHFR_1, 1
PIRSF
PIRSF000194, DHFR, 1
PRINTS
PR00070, DHFR
PROSITE
PS00075, DHFR_1, 1
PS51330, DHFR_2, 1
Feature
P0ABQ4 Escherichia coli (strain K12).
NP_BIND13 - 19NADP.
NP_BIND45 - 46NADP.
NP_BIND63 - 64NADP.
NP_BIND95 - 102NADP.
BINDING5Substrate; via carbonyl oxygen.
BINDING7NADP; via amide nitrogen and carbonyloxygen.
BINDING27Substrate.
BINDING52Substrate.
BINDING57Substrate.
BINDING76NADP; via carbonyl oxygen.
BINDING113Substrate.
P00381 Lactobacillus casei.
NP_BIND6 - 7NADP.
NP_BIND14 - 19NADP.
NP_BIND43 - 46NADP.
NP_BIND63 - 66NADP.
NP_BIND98 - 103NADP.
BINDING27Methotrexate.
BINDING27Substrate.
BINDING32Methotrexate.
BINDING32Substrate.
BINDING58Methotrexate.
BINDING58Substrate.
BINDING80NADP; via amide nitrogen.
BINDING117Substrate.
SITE22May be important for enzyme function.
General annotation
Function
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
Catalytic activity
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8- dihydrofolate + NADPH
Pathway
Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1
Sequence similarities
Belongs to the dihydrofolate reductase family
Contains 1 DHFR (dihydrofolate reductase) domain
Reference
P0ABQ4 Escherichia coli (strain K12).
6159575
Nucleotide sequence of the E coli gene coding for dihydrofolate reductase. (Nucleic Acids Res. 1980)
P00381 Lactobacillus casei.
3928445
Nucleotide sequence of the dihydrofolate reductase gene of methotrexate-resistant Lactobacillus casei. (Gene. 1985)
P00382 Escherichia coli.
6308574
The nucleotide sequence of the trimethoprim-resistant dihydrofolate reductase gene harbored by Tn7. (Nucleic Acids Res. 1983)



Related Function

Function name
Folate biosynthesis

CDS

Data Download
Scientific name NBRC No. CDS Product name
Acaricomes phytoseiuli107788C501_05345hypothetical protein
Acaryochloris marina102967AM1_4344riboflavin biosynthesis protein RibD C-terminal domain protein
AM1_4848riboflavin biosynthesis protein RibD C-terminus domain protein
Acholeplasma laidlawii14400ACL_0690dihydrofolate reductase
Acinetobacter radioresistens102413ACRAD_05_00880dihydrofolate reductase
Acinetobacter sp.100985ACT4_004_00220dihydrofolate reductase
Actinoplanes missouriensis102363AMIS_23410hypothetical protein
AMIS_68230putative dihydrofolate reductase
Aerococcus viridans12219HMPREF0061_0062dihydrofolate reductase
Alloiococcus otitis15545HMPREF9698_00446hypothetical protein
Alteromonas macleodii102226MASE_02375dihydrofolate reductase type I, trimethoprim resistance
Amycolatopsis mediterranei13415RAM_20935dihydrofolate reductase
Anoxybacillus flavithermus15317Aflv_1454Dihydrofolate reductase
Aquimarina agarilytica107695AagaZ_020100001547dihydrofolate reductase
Arcanobacterium haemolyticum15585Arch_0408Dihydrofolate reductase
Arthrobacter globiformis12137ARGLB_078_00870dihydrofolate reductase
Atopobium rimae15546ATORI0001_0356dihydrofolate reductase
Austwickia chelonae105200AUCHE_05_02610dihydrofolate reductase
Azorhizobium caulinodans14845AZC_4483dihydrofolate reductase
Bacillus amyloliquefaciens15535BAMF_2082dihydrofolate reductase
BAMF_3293putative oxidoreductase
Bacillus atrophaeus13721BATRMS_02_01420oxidoreductase
BATRMS_17_01290dihydrofolate reductase
Bacillus cereus15305BC_0650Pyrimidine Reductase
BC_2192Dihydrofolate reductase
Bacillus licheniformis12200BL03300dihydrofolate reductase
Bacillus licheniformis12195BLi02319dihydrofolate reductase DfrA
Bacillus mojavensis15718GYU_30_00250dihydrofolate reductase
Bacillus mycoides101228bmyco0001_19630Dihydrofolate reductase
bmyco0001_5480Enzyme
Bacillus pseudomycoides101232bpmyx0001_19890Dihydrofolate reductase
Bacillus psychrosaccharolyticus101233WYK_204_00440Enzyme; dihydrofolate reductase family protein
WYK_222_00150dihydrofolate reductase
Bacillus pumilus12092BAT_2109dihydrofolate reductase
BAT_3583riboflavin biosynthesis protein RibD C- domain protein
Bacillus subtilis3134BSU6633_00205dihydrofolate reductase
BSU6633_09671putative oxidoreductase
Bacillus subtilis subsp. subtilis13719BSU21810dihydrofolate reductase
BSU37220putative oxidoreductase
Bacillus thuringiensis101235bthur0008_20310Dihydrofolate reductase
bthur0008_5630Enzyme
Bacillus vallismortis101236BvalD_010100001562dihydrofolate reductase
BvalD_010100005004Dihydrofolate reductase
Bacteroides vulgatus14291BVU_1949dihydrofolate reductase
Balneola vulgarisB155_RS0100640hypothetical protein
Bergeyella zoohelcum16014HMPREF9699_02033hypothetical protein
Beutenbergia cavernae16432Bcav_2865Dihydrofolate reductase
Bradyrhizobium diazoefficiens14792bll6510dihydrofolate reductase
Brevibacillus brevis100599BBR47_43870dihydrofolate reductase
Brevibacterium linens12170BlinB_010200004219bifunctional deaminase-reductase domain protein
Brevundimonas diminuta12697BDIM_15150dihydrofolate reductase type 3
Brevundimonas subvibrioides16000Bresu_2478dihydrofolate reductase region
Caldilinea aerophila104270CLDAP_24250hypothetical protein
Caulobacter segnis15250Cseg_1294Dihydrofolate reductase
Cellulomonas fimi15513Celf_1550dihydrofolate reductase region
Cellulomonas flavigena3775Cfla_1528Dihydrofolate reductase
Cellulophaga lytica14961Celly_1950dihydrofolate reductase region
Chitinophaga pinensis15968Cpin_6452Dihydrofolate reductase
Chlamydia trachomatisCTL0876dihydrofolate reductase
Chromobacterium violaceum12614CV_1028dihydrofolate reductase
Chryseobacterium gleum15054HMPREF0204_10940dihydrofolate reductase
HMPREF0204_11536hypothetical protein
HMPREF0204_14852riboflavin biosynthesis protein RibD C-terminal domain protein
Chthoniobacter flavusCfE428DRAFT_3383dihydrofolate reductase region
Clostridium acetobutylicum13948CA_C1495Enzyme of dihydrofolate reductase family, ortholog YWFD B.subtilis
CA_C3004Dihydrofolate reductase
Clostridium kluyveri12016CKR_1935hypothetical protein
Clostridium thermocellum103400Cthe_1226dihydrofolate reductase region
Congregibacter litoralis104960KT71_05402dihydrofolate reductase
Coprobacillus sp.HMPREF1021_03287hypothetical protein
HMPREF1021_03927hypothetical protein
Coraliomargarita akajimensisCaka_1328Dihydrofolate reductase
Corynebacterium ammoniagenes12612HMPREF0281_00804dihydrofolate reductase
Corynebacterium callunae15359H924_04045hypothetical protein
Corynebacterium efficiens100395CE0918putative dihydrofolate reductase
Corynebacterium glutamicum12168Cgl0843Dihydrofolate reductase
Corynebacterium glutamicum12153KIQ_10541hypothetical protein
Corynebacterium matruchotii15360HMPREF0299_5654dihydrofolate reductase
Corynebacterium striatum15291HMPREF0308_0513dihydrofolate reductase
Corynebacterium terpenotabidum14764A606_02890dihydrofolate reductase
Cupriavidus metallidurans102507Rmet_2569dihydrofolate reductase
Cystobacter fuscus100088D187_000459Dihydrofolate reductase
Cytophaga hutchinsonii15051CHU_1297dihydrofolate reductase family protein
CHU_1569dihydrofolate reductase
Deinococcus proteolyticus101906Deipr_1760Dihydrofolate reductase
Edwardsiella tarda105688ET1_10_00390dihydrofolate reductase FolA
Enterobacter aerogenes13534EAE_11010dihydrofolate reductase
Enterobacter cloacae subsp. cloacae13535ECL_00846dihydrofolate reductase
Enterobacter hormaechei105718HMPREF9086_1783dihydrofolate reductase
HMPREF9086_4599dihydrofolate reductase
Enterococcus gilvus100696I592_01391dihydrofolate reductase
Enterococcus haemoperoxidus100709I583_00302hypothetical protein
I583_01233dihydrofolate reductase
Enterococcus hirae3181EHR_09180reductase
EHR_10060dihydrofolate reductase
EHR_13450thymidylate synthase
Enterococcus italicus107825HMPREF9088_1126dihydrofolate reductase
Enterococcus moraviensis100710I586_00296dihydrofolate reductase
I586_01228hypothetical protein
Enterococcus pallens100697I588_00467hypothetical protein
I588_02798dihydrofolate reductase
Enterococcus phoeniculicola100711I589_01183hypothetical protein
I589_01541dihydrofolate reductase
I589_03179dihydrofolate reductase
Escherichia coli3972EcolC_3607Dihydrofolate reductase
Escherichia coli13500WFL_00240dihydrofolate reductase
Escherichia coli12713Y75_0048dihydrofolate reductase
Escherichia fergusonii102419EFER_0056dihydrofolate reductase
Escherichia hermannii105704EH105704_02_03010dihydrofolate reductase FolA
Fibrobacter succinogenesFisuc_0020Dihydrofolate reductase
Fimbriimonas ginsengisoliOP10G_2548bifunctional deaminase-reductase-like protein
Finegoldia magnaFMG_0268dihydrofolate reductase
Flavobacterium johnsoniae14942Fjoh_1468dihydrofolate reductase
Fjoh_4439hypothetical protein
Flexibacter litoralis15988Fleli_3421dihydrofolate reductase
Fluviicola taffensis106335Fluta_0816dihydrofolate reductase
Frateuria aurantia3245Fraau_1543dihydrofolate reductase
Fructobacillus fructosus3516EWM_20_00700dihydrofolate reductase
Fusobacterium nucleatum subsp. NucleatumFN0241Dihydrofolate reductase
Geodermatophilus obscurus13315Gobs_3945Dihydrofolate reductase
Gloeobacter violaceusglr2476dihydrofolate reductase
Gordonia aichiensis108223GOACH_05_00250dihydrofolate reductase
Gordonia alkanivorans16433GOALK_077_00510dihydrofolate reductase
Gordonia amarae15530GOAMR_71_00150dihydrofolate reductase
Gordonia amicalis100051GOAMI_19_00270dihydrofolate reductase
Gordonia araii100433GOARA_036_00320dihydrofolate reductase
Gordonia bronchialis16047Gbro_2177dihydrofolate reductase region
Gordonia effusa100432GOEFS_075_00250dihydrofolate reductase
Gordonia hirsuta16056GOHSU_42_00220dihydrofolate reductase
Gordonia namibiensis108229GONAM_14_01260dihydrofolate reductase
Gordonia otitidis100426GOOTI_087_00230dihydrofolate reductase
Gordonia polyisoprenivorans16320GOPIP_070_01790dihydrofolate reductase
Gordonia rhizosphera16068GORHZ_154_00330dihydrofolate reductase
Gordonia rubripertincta101908GORBP_053_01570dihydrofolate reductase
Gordonia sihwensis108236GSI01S_13_00220dihydrofolate reductase
Gordonia soli108243GS4_42_00300dihydrofolate reductase
Gordonia sputi100414GOSPT_046_00370dihydrofolate reductase
Gordonia terrae100016GOTRE_077_00150dihydrofolate reductase
Haloarcula vallismortis14741C437_07602dihydrofolate reductase
C437_15976dihydrofolate reductase
Halobacillus halophilus102448HBHAL_2149conserved hypothetical protein
HBHAL_3221dihydrofolate reductase
Halomonas elongata15536HELO_1702dihydrofolate reductase
Haloplasma contractileHLPCO_000240Dihydrofolate reductase protein
Hylemonella gracilis14920HGR_13829dihydrofolate reductase
Hyphomonas neptunium14232HNE_0463dihydrofolate reductase
Ignavibacterium album101810IALB_2114Dihydrofolate reductase
Intrasporangium calvum12989Intca_2184dihydrofolate reductase
Jonesia denitrificans15587Jden_1031Dihydrofolate reductase
Kineococcus radiotolerans101839Krad_2685bifunctional deaminase-reductase domain protein
Krad_4438Dihydrofolate reductase
Kineosphaera limosa100340KILIM_004_00570dihydrofolate reductase
Klebsiella pneumoniae14438KPR_0969
Klebsiella pneumoniae subsp. rhinoscleromatis105682HMPREF0484_4981dihydrofolate reductase
Kocuria rhizophila103217KRH_05680dihydrofolate reductase
Kordia algicida100336KAOT1_13007dihydrofolate reductase type I; trimethoprim resistance
Kribbella flavida14399Kfla_5968Dihydrofolate reductase
Kytococcus sedentarius15357Ksed_09350dihydrofolate reductase
Labrenzia aggregata16684SIAM614_19396probable dihydrofolate reductase protein
Lactobacillus acidipiscis102164LaciK1_010100003263dihydrofolate reductase subunit
LaciK1_010100010846riboflavin biosynthesis protein RibD C-terminal domain-containing protein
Lactobacillus animalis15882LaniK3_010100004768dihydrofolate reductase
Lactobacillus casei15883LCABL_16080Dihydrofolate reductase
Lactobacillus delbrueckii subsp. bulgaricus13953Ldb0788Dihydrofolate reductase
Lactobacillus farciminis107150LfarK3_010100003832dihydrofolate reductase
LfarK3_010100007731dihydrofolate reductase
Lactobacillus fermentum15885HMPREF0511_1286dihydrofolate reductase
Lactobacillus fermentum3956LAF_0888dihydrofolate reductase
Lactobacillus fructivorans13954LACFR_02_01130dihydrofolate reductase region
Lactobacillus helveticus15019HMPREF0518_0454dihydrofolate reductase
Lactobacillus hilgardii15886HMPREF0519_2182dihydrofolate reductase
Lactobacillus plantarum subsp. plantarum15891HMPREF0531_10866dihydrofolate reductase
Lactobacillus reuteri15892LAR_0740dihydrofolate reductase
Leadbetterella byssophila106382Lbys_0789bifunctional deaminase-reductase domain protein
Lbys_2007dihydrofolate reductase
Lentisphaera araneosaLNTAR_13747Dihydrofolate reductase
LNTAR_24149dihydrofolate reductase region
Leuconostoc lactis107866EY7_569_00020Dihydrofolate reductase
Leuconostoc mesenteroides subsp. cremoris107766HMPREF0555_1179dihydrofolate reductase
Leuconostoc mesenteroides subsp. mesenteroides100496LEUM_0757dihydrofolate reductase
Leuconostoc pseudomesenteroides107767LpseK3_010100002704dihydrofolate reductase
LpseK3_010100014705dihydrofolate reductase
Magnetospirillum gryphiswaldense15271MGR_1240Dihydrofolate reductase
Magnetospirillum magnetotacticum15272Magn03005379COG0262: Dihydrofolate reductase
Magn03008421COG0262: Dihydrofolate reductase
Magn03010980COG0262: Dihydrofolate reductase
Marinomonas mediterranea103028Marme_0712Dihydrofolate reductase
Mariprofundus ferrooxydansSPV1_12435Dihydrofolate reductase
Marivirga tractuosa15989Ftrac_0033dihydrofolate reductase
Ftrac_3444bifunctional deaminase-reductase domain protein
Meiothermus ruber106122Mrub_1855Dihydrofolate reductase
Meiothermus silvanus106475Mesil_0096Dihydrofolate reductase
Mesoplasma florum100688Mfl383dihydrofolate reductase
Methylobacterium radiotolerans15690Mrad2831_3892dihydrofolate reductase
Mrad2831_4526Dihydrofolate reductase
Micrococcus luteus3333Mlut_17470dihydrofolate reductase
Microlunatus phosphovorus101784MLP_38770dihydrofolate reductase
Microscilla marina16560M23134_05250dihydrofolate reductase
M23134_08207riboflavin biosynthesis protein RibD C-terminal domain protein
Mobilicoccus pelagius104925MOPEL_009_00590dihydrofolate reductase
Mycoplasma anatis14861GIG_01840hypothetical protein
GIG_03352dihydrofolate reductase
Mycoplasma arginini14476F805_01_01330dihydrofolate reductase
Mycoplasma gallisepticum14855F809_02_01260dihydrofolate reductase
F809_03_00850dihydrofolate reductase
Mycoplasma hyorhinis14858F801_00220dihydrofolate reductase
F801_01755dihydrofolate reductase
Mycoplasma pneumoniae14401MPNE_0342dihydrofolate reductase
MPNE_0374dihydrofolate reductase
Myroides odoratus14945Myrod_2371dihydrofolate reductase
Myrod_3283bifunctional deaminase-reductase domain protein
Myrod_3692hypothetical protein
Nakamurella multipartita105858Namu_2811Dihydrofolate reductase
Niastella koreensis106392Niako_4591dihydrofolate reductase
Nitrosomonas europaea14298NE0567Dihydrofolate reductase
Nitrososphaera viennensisNVIE_011950hypothetical protein
Ochrobactrum anthropi15819Oant_1793Dihydrofolate reductase
Ochrobactrum intermedium15820OINT_1001525Dihydrofolate reductase type 3
Oscillibacter valericigenes101213OBV_13630dihydrofolate reductase
Paenibacillus alvei3343PAV_7c00870dihydrofolate reductase DfrA
Paenibacillus peoriae15541PpeoK3_010100006480dihydrofolate reductase
PpeoK3_010100014891hypothetical protein
Paenibacillus polymyxa15309PPT_13635dihydrofolate reductase
PPT_14660dihydrofolate reductase
Pedobacter heparinus12017Phep_1421Dihydrofolate reductase
Pedobacter saltans100064Pedsa_1464bifunctional deaminase-reductase domain protein
Pedsa_2045dihydrofolate reductase
Pelobacter carbinolicus103641Pcar_2754dihydrofolate reductase
Phaeobacter gallaeciensis16654PGA1_c21170dihydrofolate reductase FolA
Phycisphaera mikurensis102666PSMK_14210dihydrofolate reductase
Propionibacterium acidipropionici12425PACID_23820Dihydrofolate reductase
Propionibacterium avidum15671HMPREF9153_0279dihydrofolate reductase
Proteus mirabilis105697HMPREF0693_2551dihydrofolate reductase
Providencia alcalifaciens105687PROVALCAL_00924riboflavin biosynthesis protein RibD C-terminal domain protein
PROVALCAL_02266dihydrofolate reductase
Pseudomonas putida100650PP_5132dihydrofolate reductase
Pseudomonas stutzeri14165PSTAB_3977dihydrofolate reductase
Rahnella aquatilis105701Rahaq2_3864dihydrofolate reductase
Renibacterium salmoninarum15589RSal33209_0957dihydrofolate reductase
Rhizobium etli15573RHE_CH02798dihydrofolate reductase protein
Rhizobium sp.101917NGR_c20290dihydrofolate reductase
Rhizobium tropici15247RTCIAT899_CH11060dihydrofolate reductase
Rhodobacter sphaeroides12203RSP_0389dihydrofolate reductase
Rhodococcus erythropolis100887RER_44620dihydrofolate reductase
Rhodococcus opacus108011ROP_19630dihydrofolate reductase
Roseobacter denitrificans15277RD1_1875dihydrofolate reductase
Roseobacter litoralis15278RLO149_c009710putative dihydrofolate reductase
Rothia dentocariosa12531HMPREF0733_10373dihydrofolate reductase
Rothia mucilaginosa15673ROTMU0001_0632dihydrofolate reductase
Saccharomonospora cyanea14841SaccyDRAFT_2137dihydrofolate reductase
Saccharothrix espanaensis15066BN6_78140Dihydrofolate reductase
Salinibacter ruberSRU_0412dihydrofolate reductase
Salinispora tropica105044Strop_4238bifunctional deaminase-reductase domain protein
Sanguibacter keddieii16158Sked_14580dihydrofolate reductase
Sked_23300dihydrofolate reductase
Selenomonas ruminantium subsp. lactilytica103574SELR_27250putative 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase/dihydrofolate reductase
Serratia odorifera102598HMPREF0758_0557dihydrofolate reductase
Shimwellia blattae105725EB105725_11_01420dihydrofolate reductase FolA
Solitalea canadensis15130Solca_2293dihydrofolate reductase
Solca_3594dihydrofolate reductase
Sphingobacterium spiritivorum14948HMPREF0766_14418dihydrofolate reductase
Sphingobium japonicum101211SJA_C1-22930dihydrofolate reductase
Sphingobium sp.103272SLG_05410dihydrofolate reductase
Sphingomonas echinoides15742SechA1_010100015612dihydrofolate reductase
Sphingomonas wittichii105917Swit_3786dihydrofolate reductase
Stackebrandtia nassauensis102104Snas_5799bifunctional deaminase-reductase domain protein
Staphylococcus epidermidis12993SE_1119dihydrofolate reductase
Staphylococcus saprophyticus subsp. saprophyticus102446SSP1313dihydrofolate reductase
Starkeya novella14993Snov_3092Dihydrofolate reductase
Streptococcus equinus12553HMPREF0819_0618dihydrofolate reductase
Streptococcus mitis106071SM12261_1142dihydrofolate reductase
Streptomyces mobaraensis13819H340_24150dihydrofolate reductase
Streptosporangium roseum3776Sros_4921Dihydrofolate reductase
Synechococcus elongatusSynpcc7942_1819conserved hypothetical protein
Tetragenococcus halophilus12172TEH_15920dihydrofolate reductase
Thauera linaloolentis102519C666_04665dihydrofolate reductase
Thermotoga maritima100826TM_1641dihydrofolate reductase
Thermotoga naphthophila104846Tnap_1165dihydrofolate reductase region
Thermotoga neapolitana107923CTN_0817Dihydrofolate reductase
Thermotoga petrophila104847Tpet_1150Dihydrofolate reductase-like protein
Tsukamurella paurometabola16120Tpau_1761Dihydrofolate reductase
Tpau_2516bifunctional deaminase-reductase domain protein
Turicella otitidis106139HMPREF9719_01063hypothetical protein
Vibrio alginolyticus15630N646_2522dihydrofolate reductase
Vibrio ichthyoenteri15847VII00023_17071hypothetical protein
Vibrio metschnikovii103153VIB_002094dihydrofolate reductase
Vibrio orientalis15638VIOR3934_09775hypothetical protein
Vibrio tubiashii15644VITU9109_25650hypothetical protein
Vibrio vulnificus15645B736_10520diacylglycerol kinase
Weeksella virosa16016Weevi_0641Dihydrofolate reductase
Xylanimonas cellulosilytica107835Xcel_2833Dihydrofolate reductase
Yersinia bercovieri105717yberc0001_9600Dihydrofolate reductase
Yersinia rohdei105715yrohd0001_5510Dihydrofolate reductase
Zymomonas mobilis subsp. pomaceae13757Zymop_0869dihydrofolate reductase region