Rule : Riboflavin synthase (RIBE)

Rule Description

ID	NRULE_0204
Rule name	RIBE
Created	2013-04-09
Protein name	Protein name Full Riboflavin synthase Short RS EC EC 2.5.1.9
Gene name	ribE
Rule Trigger	TIGRFAMs; TIGR00187; hit=1
Cross Reference	Gene Ontology GO GO:0000906, F:6,7-dimethyl-8-ribityllumazine synthase activity, IDA:EcoCyc GO:0016491, F:oxidoreductase activity, IEA:InterPro GO:0004746, F:riboflavin synthase activity, IDA:EcoCyc GO:0009231, P:riboflavin biosynthetic process, IDA:EcoCyc Phylogenomic databases eggNOG COG0307, - HOGENOM HOG000151758, - KO K00793, - ProtClustDB PRK09289, - Enzyme and pathway databases BioCyc MetaCyc:RIBOFLAVIN-SYN-MONOMER, - UniPathway UPA00275, UER00405 Family and domain databases InterPro IPR023366, ATPase_F1/A1-cplx_a_su_N IPR001783, Lumazine-bd IPR026017, Lumazine-bd_dom IPR017938, Riboflavin_synthase-like_b-brl Pfam PF00677, Lum_binding, 2 PIRSF PIRSF000498, Riboflavin_syn_A, 1 TIGRFAMs TIGR00187, ribE, 1 PROSITE PS51177, LUMAZINE_BIND, 2
Feature	Not assigned
General annotation	Function Catalyzes the dismutation of two molecules of 6,7- dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil Catalytic activity 2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine Pathway Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D- ribitylamino)uracil: step 2/2 Subunit structure Homotrimer. Unlike in B.subtilis, does not interact with 6,7-dimethyl-8-ribityllumazine synthase Sequence similarities Contains 2 lumazine-binding repeats
Reference	P0AFU8 Escherichia coli (strain K12). 9022701 Cloning, sequencing, mapping and hyperexpression of the ribC gene coding for riboflavin synthase of Escherichia coli. (Eur J Biochem. 1996) 9023191 Analysis of the boundaries of Salmonella pathogenicity island 2 and the corresponding chromosomal region of Escherichia coli K-12. (J Bacteriol. 1997) 9097039 A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map. (DNA Res. 1996) 9278503 The complete genome sequence of Escherichia coli K-12. (Science. 1997) 16738553 Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. (Mol Syst Biol. 2006) 11399071 The solution structure of the N-terminal domain of riboflavin synthase. (J Mol Biol. 2001) 11377200 Crystal structure of riboflavin synthase. (Structure. 2001) 12927541 The structure of the N-terminal domain of riboflavin synthase in complex with riboflavin at 2.6A resolution. (J Mol Biol. 2003)

Related Function

Function name
Riboflavin biosynthesis

CDS


Scientific name	NBRC No.	CDS	Product name
Acaricomes phytoseiuli	107788	C501_08365	hypothetical protein
Acaryochloris marina	102967	AM1_1983	riboflavin synthase, alpha subunit
Acetobacter aceti	14818	AaceN1_010100007817	riboflavin synthase subunit alpha
Acetobacter pasteurianus	105190	APA32_18570	Riboflavin synthase alpha subunit
Acetobacter pasteurianus	101655	APT_1570	riboflavin synthase alpha subunit
Acetobacter tropicalis	101654	ATPR_1354	riboflavin synthase alpha subunit
Acidiphilium multivorum	100883	ACMV_23650	riboflavin synthase alpha chain
Acidithiobacillus ferrooxidans		Lferr_0474	riboflavin synthase, alpha subunit
Acidobacterium capsulatum	15755	ACP_3415	riboflavin synthase, alpha subunit
Acinetobacter radioresistens	102413	ACRAD_28_00300	riboflavin synthase
Acinetobacter sp.	100985	ACT4_010_00420	riboflavin synthase alpha chain
Actinoalloteichus cyanogriseus	14455	G443_17_00320	riboflavin synthase subunit alpha
Actinoalloteichus spitiensis	102582	ACTIDRAF_26225	hypothetical protein
Actinomadura atramentaria	14695	G339_09130	riboflavin synthase subunit alpha
Actinoplanes missouriensis	102363	AMIS_61950	putative riboflavin synthase alpha subunit
Actinopolyspora iraqiensis	103187	ACTIR_363_00040	riboflavin synthase subunit alpha
Actinosynnema mirum	14064	Amir_5219	riboflavin synthase, alpha subunit
Aerococcus viridans	12219	HMPREF0061_1456	riboflavin synthase, alpha subunit
Alicyclobacillus acidocaldarius subsp. acidocaldarius	15652	Aaci_0937	riboflavin synthase, alpha subunit
Alloiococcus otitis	15545	HMPREF9698_00869	riboflavin synthase, alpha subunit
Alteromonas macleodii	102226	MASE_12420	riboflavin synthase subunit alpha
Amycolatopsis azurea	14573	C791_6986	Riboflavin synthase
Amycolatopsis mediterranei	13415	RAM_14090	riboflavin synthase alpha chain
Anoxybacillus flavithermus	15317	Aflv_1016	Riboflavin synthase alpha chain
Aquifex aeolicus		aq_1707	riboflavin synthase alpha chain
Aquimarina agarilytica	107695	AagaZ_020100005310	riboflavin synthase subunit alpha
Ardenticatena maritima		ARMA_1603	riboflavin synthase
Arthrobacter globiformis	12137	ARGLB_051_00100	riboflavin synthase alpha chain
Austwickia chelonae	105200	AUCHE_05_05820	riboflavin synthase alpha chain
Azorhizobium caulinodans	14845	AZC_1264	riboflavin synthase subunit alpha
Bacillus amyloliquefaciens	15535	BAMF_2226	riboflavin synthase (alpha subunit)
Bacillus atrophaeus	13721	BATRMS_17_02770	riboflavin synthase subunit alpha
Bacillus cereus	15305	BC_4110	Riboflavin synthase alpha chain
Bacillus licheniformis	12200	BL01890	riboflavin synthase (alpha subunit)
Bacillus licheniformis	12195	BLi02474	riboflavin synthase alpha subunit RibE
Bacillus mojavensis	15718	GYU_39_00220	riboflavin synthase subunit alpha
Bacillus mycoides	101228	bmyco0001_37370	Riboflavin synthase alpha subunit
Bacillus pseudomycoides	101232	bpmyx0001_35920	Riboflavin synthase alpha subunit
Bacillus psychrosaccharolyticus	101233	WYK_005_00070	riboflavin synthase subunit alpha
Bacillus pumilus	12092	BAT_1957	riboflavin synthase, alpha subunit
Bacillus subtilis	3134	BSU6633_14182	riboflavin synthase subunit alpha
Bacillus subtilis subsp. subtilis	13719	BSU23270	riboflavin synthase (alpha subunit)
Bacillus thuringiensis	101235	bthur0008_39030	Riboflavin synthase alpha subunit
Bacillus vallismortis	101236	BvalD_010100002607	riboflavin synthase subunit alpha
Bacteroides vulgatus	14291	BVU_2721	riboflavin synthase alpha chain
Balneola vulgaris		B155_RS0110990	riboflavin synthase subunit alpha
Bergeyella zoohelcum	16014	HMPREF9699_00748	riboflavin synthase, alpha subunit
Beutenbergia cavernae	16432	Bcav_1765	riboflavin synthase, alpha subunit
Bradyrhizobium diazoefficiens	14792	bll5030	riboflavin synthase alpha chain
Brevibacillus brevis	100599	BBR47_48130	riboflavin synthase alpha subunit
Brevundimonas diminuta	12697	BDIM_11660	riboflavin synthase, alpha subunit
Brevundimonas subvibrioides	16000	Bresu_1886	riboflavin synthase, alpha subunit
Calditerrivibrio nitroreducens	101217	Calni_1659	riboflavin synthase, alpha subunit
Candidatus Nitrosopumilus sp.		NSED_08750	riboflavin synthase subunit alpha
Candidatus Solibacter usitatus		Acid_4223	riboflavin synthase, alpha subunit
Catenulispora acidiphila	102108	Caci_3107	riboflavin synthase, alpha subunit
Cellulomonas fimi	15513	Celf_1964	riboflavin synthase, alpha subunit
Cellulomonas flavigena	3775	Cfla_1859	riboflavin synthase, alpha subunit
Cellulophaga lytica	14961	Celly_1272	riboflavin synthase, alpha subunit
Cenarchaeum symbiosum		CENSYa_1754	riboflavin synthase alpha chain
Chitinispirillum alkaliphilum		CHISP_1005	riboflavin synthase subunit alpha
Chitinivibrio alkaliphilus		CALK_0702	riboflavin synthase subunit alpha
Chitinophaga pinensis	15968	Cpin_1696	riboflavin synthase, alpha subunit
Chlamydia trachomatis		CTL0662	riboflavin synthase alpha chain
Chloracidobacterium thermophilum B		Cabther_A1966	riboflavin synthase, alpha subunit
Chlorobaculum tepidum	103806	CT0756	riboflavin synthase, alpha subunit
Chlorobium limicola	103803	Clim_0835	riboflavin synthase, alpha subunit
Chromobacterium violaceum	12614	CV_2387	riboflavin synthase, alpha chain
Chryseobacterium gleum	15054	HMPREF0204_11621	riboflavin synthase, alpha subunit
Chrysiogenes arsenatis		P304_RS0104870	hypothetical protein
Chthoniobacter flavus		CfE428DRAFT_5904	riboflavin synthase, alpha subunit
Chthonomonas calidirosea		CCALI_00285	riboflavin synthase alpha chain
Clostridium acetobutylicum	13948	CA_C0591	Riboflavin synthase alpha chain
Clostridium clariflavum	101661	Clocl_1125	riboflavin synthase alpha chain
Clostridium kluyveri	12016	CKR_1903	hypothetical protein
Clostridium thermocellum	103400	Cthe_0105	riboflavin synthase, alpha subunit
Conexibacter woesei	100937	Cwoe_3707	riboflavin synthase, alpha subunit
Congregibacter litoralis	104960	KT71_01405	riboflavin synthase alpha chain
Coraliomargarita akajimensis		Caka_1769	riboflavin synthase, alpha subunit
Corynebacterium ammoniagenes	12612	HMPREF0281_00464	riboflavin synthase, alpha subunit
Corynebacterium callunae	15359	H924_07550	riboflavin synthase subunit alpha
Corynebacterium efficiens	100395	CE1715	putative riboflavin synthase alpha chain
Corynebacterium glutamicum	12168	Cgl1596	Riboflavin synthase alpha chain
Corynebacterium glutamicum	12153	KIQ_10037	riboflavin synthase subunit alpha
Corynebacterium matruchotii	15360	HMPREF0299_6476	riboflavin synthase, alpha subunit
Corynebacterium striatum	15291	HMPREF0308_0669	riboflavin synthase, alpha subunit
Corynebacterium terpenotabidum	14764	A606_05855	riboflavin synthase subunit alpha
Cupriavidus metallidurans	102507	Rmet_2689	riboflavin synthase alpha chain
Cystobacter fuscus	100088	D187_004606	Riboflavin synthase
Cytophaga hutchinsonii	15051	CHU_1926	riboflavin synthase, alpha subunit
Deferribacter desulfuricans	101012	DEFDS_1097	riboflavin synthase, alpha subunit
Dehalococcoides mccartyi		DehaBAV1_1000	riboflavin synthase, alpha subunit
Deinococcus proteolyticus	101906	Deipr_1596	riboflavin synthase, alpha subunit
Desulfovibrio magneticus	104933	DMR_04650	riboflavin synthase alpha chain
Desulfovibrio vulgaris subsp. vulgaris	104121	DVU_1200	riboflavin synthase, alpha subunit
Edwardsiella tarda	105688	ET1_05_00020	riboflavin synthase
Endomicrobium proavitum		Epro_0585	riboflavin synthase, alpha subunit
Enterobacter aerogenes	13534	EAE_17765	riboflavin synthase subunit alpha
Enterobacter cloacae subsp. cloacae	13535	ECL_02345	riboflavin synthase subunit alpha
Enterobacter hormaechei	105718	HMPREF9086_0516	riboflavin synthase subunit alpha
Enterococcus hirae	3181	EHR_07315	riboflavin synthase subunit alpha
Escherichia coli	3972	EcolC_1967	riboflavin synthase, alpha subunit
Escherichia coli	13500	WFL_08970	riboflavin synthase subunit alpha
Escherichia coli	12713	Y75_1659	riboflavin synthase, alpha subunit
Escherichia fergusonii	102419	EFER_1382	riboflavin synthase, alpha subunit
Escherichia hermannii	105704	EH105704_01_00320	riboflavin synthase
Fibrobacter succinogenes		Fisuc_2735	riboflavin synthase, alpha subunit
Fimbriimonas ginsengisoli		OP10G_2004	riboflavin synthase, alpha subunit
Fischerella sp.		PCC9339_RS0119755	riboflavin synthase subunit alpha
Flavobacterium johnsoniae	14942	Fjoh_0650	riboflavin synthase, alpha subunit
Flexibacter litoralis	15988	Fleli_1575	riboflavin synthase alpha chain
Fluviicola taffensis	106335	Fluta_1726	riboflavin synthase, alpha subunit
Frateuria aurantia	3245	Fraau_0451	riboflavin synthase, alpha subunit
Fusobacterium nucleatum subsp. Nucleatum		FN1507	Riboflavin synthase alpha chain
Gemmata obscuriglobus		GEMOB_RS22950	riboflavin synthase subunit alpha
Gemmatimonas aurantiaca	100505	GAU_1472	riboflavin synthase alpha chain
Geodermatophilus obscurus	13315	Gobs_3112	riboflavin synthase, alpha subunit
Gloeobacter violaceus		glr3604	riboflavin synthase alpha chain
Gluconacetobacter hansenii	14816	GXY_00414	riboflavin synthase subunit alpha
Gluconobacter frateurii	101659	GfraN1_010100006431	riboflavin synthase subunit alpha
Gordonia aichiensis	108223	GOACH_05_01970	riboflavin synthase alpha chain
Gordonia alkanivorans	16433	GOALK_017_00300	riboflavin synthase alpha chain
Gordonia amarae	15530	GOAMR_03_00660	riboflavin synthase alpha chain
Gordonia amicalis	100051	GOAMI_17_00670	riboflavin synthase alpha chain
Gordonia araii	100433	GOARA_064_00440	riboflavin synthase alpha chain
Gordonia bronchialis	16047	Gbro_2354	riboflavin synthase, alpha subunit
Gordonia effusa	100432	GOEFS_049_00270	riboflavin synthase alpha chain
Gordonia hirsuta	16056	GOHSU_18_00690	riboflavin synthase alpha chain
Gordonia namibiensis	108229	GONAM_12_00480	riboflavin synthase alpha chain
Gordonia otitidis	100426	GOOTI_048_00120	riboflavin synthase alpha chain
Gordonia polyisoprenivorans	16320	GOPIP_056_00840	riboflavin synthase alpha chain
Gordonia rhizosphera	16068	GORHZ_090_00150	riboflavin synthase alpha chain
Gordonia sihwensis	108236	GSI01S_03_00380	riboflavin synthase alpha chain
Gordonia soli	108243	GS4_18_00670	riboflavin synthase
Gordonia sputi	100414	GOSPT_022_00640	riboflavin synthase alpha chain
Gordonia terrae	100016	GOTRE_081_00480	riboflavin synthase alpha chain
Haloarcula vallismortis	14741	C437_03057	riboflavin synthase subunit alpha
Halobacillus halophilus	102448	HBHAL_4680	riboflavin synthase alpha subunit
Halobacterium sp.		VNG_2624G	riboflavin synthase alpha subunit
Halomonas elongata	15536	HELO_2996	riboflavin synthase subunit alpha
Haloplasma contractile		HLPCO_001292	Riboflavin synthase alpha-chain protein
Herpetosiphon aurantiacus		Haur_1304	riboflavin synthase, alpha subunit
Holophaga foetida		HOLFODRAFT_RS20575	hypothetical protein
Hylemonella gracilis	14920	HGR_09498	riboflavin synthase subunit alpha
Hyphomonas neptunium	14232	HNE_2057	riboflavin synthase, alpha subunit
Ignavibacterium album	101810	IALB_2405	Riboflavin synthase subunit alpha
Intrasporangium calvum	12989	Intca_1622	riboflavin synthase, alpha subunit
Jonesia denitrificans	15587	Jden_0681	riboflavin synthase, alpha subunit
Kineococcus radiotolerans	101839	Krad_2979	riboflavin synthase, alpha subunit
Kineosphaera limosa	100340	KILIM_040_00150	riboflavin synthase alpha chain
Kitasatospora setae	14216	KSE_11620	putative riboflavin synthase alpha chain
Klebsiella pneumoniae	14438	KPR_3042
Klebsiella pneumoniae subsp. rhinoscleromatis	105682	HMPREF0484_4720	riboflavin synthase, alpha subunit
Kocuria rhizophila	103217	KRH_11700	riboflavin synthase alpha chain/3,4-dihydroxy-2-butanone 4-phosphate synthase
Kordia algicida	100336	KAOT1_16453	riboflavin synthase, alpha subunit
Kribbella flavida	14399	Kfla_5136	riboflavin synthase, alpha subunit
Ktedonobacter racemifer		Krac_2156	riboflavin synthase, alpha subunit
Kyrpidia tusciae	15312	Btus_1825	riboflavin synthase, alpha subunit
Kytococcus sedentarius	15357	Ksed_01560	riboflavin synthase, alpha subunit
Labrenzia aggregata	16684	SIAM614_10433	riboflavin synthase subunit alpha
Lactobacillus farciminis	107150	LfarK3_010100008241	riboflavin synthase subunit alpha
Lactobacillus fermentum	15885	HMPREF0511_0775	riboflavin synthase, alpha subunit
Lactobacillus fermentum	3956	LAF_0775	riboflavin synthase alpha subunit
Lactobacillus plantarum subsp. plantarum	15891	HMPREF0531_10515	riboflavin synthase, alpha subunit
Lactobacillus reuteri	15892	LAR_0825	riboflavin synthase alpha subunit
Leadbetterella byssophila	106382	Lbys_1411	riboflavin synthase, alpha subunit
Lentisphaera araneosa		LNTAR_15832	riboflavin synthase subunit alpha
Leptospira interrogans		LA_1145	riboflavin synthase subunit alpha
Leuconostoc lactis	107866	EY7_758_00040	Riboflavin synthase, alpha subunit
Leuconostoc mesenteroides subsp. mesenteroides	100496	LEUM_0823	Riboflavin synthase alpha chain
Limnochorda pilosa	110152	LIP_3300	riboflavin synthase subunit alpha
Magnetospirillum gryphiswaldense	15271	MGR_2799	riboflavin synthase, alpha subunit
Magnetospirillum magnetotacticum	15272	Magn03003352	COG0307: Riboflavin synthase alpha chain
		Magn03004371	COG0307: Riboflavin synthase alpha chain
		Magn03009109	COG0307: Riboflavin synthase alpha chain
Marinomonas mediterranea	103028	Marme_1111	riboflavin synthase, alpha subunit
Mariprofundus ferrooxydans		SPV1_01702	riboflavin synthase subunit alpha
Marivirga tractuosa	15989	Ftrac_1487	riboflavin synthase, alpha subunit
Meiothermus ruber	106122	Mrub_1254	riboflavin synthase, alpha subunit
Meiothermus silvanus	106475	Mesil_3463	putative hypothetical protein
Methylacidiphilum infernorum		Minf_2397	Riboflavin synthase alpha chain
Methylobacterium radiotolerans	15690	Mrad2831_3959	riboflavin synthase, alpha subunit
Microlunatus phosphovorus	101784	MLP_15290	riboflavin synthase alpha chain
Micromonospora aurantiaca	16155	Micau_2357	riboflavin synthase, alpha subunit
Microscilla marina	16560	M23134_00071	riboflavin synthase, alpha subunit
Mobilicoccus pelagius	104925	MOPEL_130_01600	riboflavin synthase alpha chain
Myroides odoratus	14945	Myrod_1921	riboflavin synthase alpha chain
Nakamurella multipartita	105858	Namu_4152	riboflavin synthase, alpha subunit
Niastella koreensis	106392	Niako_4947	riboflavin synthase alpha chain
Nitriliruptor alkaliphilus		NitalDRAFT_3422	riboflavin synthase alpha chain
Nitrosomonas europaea	14298	NE2555	Riboflavin synthase alpha chain family lumazine binding domain
Nitrososphaera viennensis		NVIE_2243	riboflavin synthase alpha chain
Nitrospina gracilis		NITGR_910040	Riboflavin synthase alpha chain
Nocardiopsis dassonvillei	14626	Ndas_0860	riboflavin synthase, alpha subunit
Nostoc sp.		all5258	riboflavin synthase alpha chain
Oceanithermus profundus	100410	Ocepr_1718	riboflavin synthase, alpha subunit
Ochrobactrum anthropi	15819	Oant_2527	riboflavin synthase, alpha subunit
Ochrobactrum intermedium	15820	OINT_1000798	riboflavin synthase, alpha subunit
Oscillibacter valericigenes	101213	OBV_01240	6,7-dimethyl-8-ribityllumazine synthase
Paenibacillus alvei	3343	PAV_3c05340	riboflavin synthase alpha chain RibE
Paenibacillus peoriae	15541	PpeoK3_010100005310	riboflavin synthase subunit alpha
Paenibacillus polymyxa	15309	PPT_16785	riboflavin synthase subunit alpha
Pedobacter heparinus	12017	Phep_3288	riboflavin synthase, alpha subunit
Pedobacter saltans	100064	Pedsa_1826	riboflavin synthase, alpha subunit
Pelobacter carbinolicus	103641	Pcar_1446	riboflavin synthase
Pelobacter propionicus	103807	Ppro_1595	riboflavin synthase, alpha subunit
Phaeobacter gallaeciensis	16654	PGA1_c08910	riboflavin synthase alpha chain
Photobacterium damselae subsp. damselae corrig.	15633	VDA_002335	riboflavin synthase alpha chain
Photobacterium damselae subsp. damselae corrig.	15633	VDA_002680	riboflavin synthase alpha chain
Phycisphaera mikurensis	102666	PSMK_17020	riboflavin synthase alpha chain
Planctomyces brasiliensis	103401	Plabr_2632	riboflavin synthase, alpha subunit
Prochlorococcus marinus subsp. marinus		Pro_0438	Riboflavin synthase alpha chain
Propionibacterium acidipropionici	12425	PACID_24660	Riboflavin synthase alpha chain
Propionibacterium avidum	15671	HMPREF9153_0360	riboflavin synthase subunit alpha
Proteus mirabilis	105697	HMPREF0693_0975	riboflavin synthase, alpha subunit
Providencia alcalifaciens	105687	PROVALCAL_03150	riboflavin synthase, alpha subunit
Pseudomonas putida	100650	PP_0515	riboflavin synthase, alpha subunit
Pseudomonas putida	100650	PP_2916	riboflavin synthase, alpha subunit
Pseudomonas stutzeri	14165	PSTAB_0723	riboflavin synthase subunit alpha
Rahnella aquatilis	105701	Rahaq2_2818	riboflavin synthase, alpha subunit
Renibacterium salmoninarum	15589	RSal33209_2347	riboflavin synthase, alpha chain
Rhizobium etli	15573	RHE_CH01511	riboflavin synthase, alpha chain protein
Rhizobium sp.	101917	NGR_c09600	riboflavin synthase alpha chain
Rhizobium tropici	15247	RTCIAT899_CH06475	riboflavin synthase, alpha subunit
Rhodobacter capsulatus	16581	RCAP_rcc03076	riboflavin synthase, alpha subunit
Rhodobacter sphaeroides	12203	RSP_0758	Lumazine-binding protein
Rhodococcus erythropolis	100887	RER_30210	riboflavin synthase alpha chain
Rhodococcus opacus	108011	ROP_69500	riboflavin synthase alpha chain
Roseobacter denitrificans	15277	RD1_1800	riboflavin synthase, alpha subunit
Roseobacter litoralis	15278	RLO149_c029180	riboflavin synthase alpha chain
Rothia dentocariosa	12531	HMPREF0733_11815	riboflavin synthase, alpha subunit
Rothia mucilaginosa	15673	ROTMU0001_0385	riboflavin synthase, alpha subunit
Rubrobacter xylanophilus	100952	Rxyl_1365	riboflavin synthase, alpha subunit
Saccharomonospora azurea	14651	SacazDRAFT_00050	riboflavin synthase, alpha subunit
Saccharomonospora cyanea	14841	SaccyDRAFT_1936	riboflavin synthase, alpha subunit
Saccharomonospora glauca	14831	SacglDRAFT_01789	riboflavin synthase, alpha subunit
Saccharomonospora viridis	12207	Svir_15720	riboflavin synthase, alpha subunit
Saccharopolyspora erythraea	13426	SACE_2122	riboflavin synthase alpha chain
Saccharopolyspora spinosa	15153	SspiN1_010100026444	riboflavin synthase subunit alpha
Saccharothrix espanaensis	15066	BN6_62930	Riboflavin synthase alpha chain
Salinibacter ruber		SRU_2303	riboflavin synthase, alpha subunit
Salinispora arenicola	105043	Q5S_1270_00020	riboflavin synthase subunit alpha
Salinispora tropica	105044	Strop_1875	riboflavin synthase, alpha subunit
Sanguibacter keddieii	16158	Sked_18150	riboflavin synthase, alpha subunit
Selenomonas ruminantium subsp. lactilytica	103574	SELR_09860	putative riboflavin synthase alpha chain
Serratia odorifera	102598	HMPREF0758_3930	riboflavin synthase, alpha subunit
Shimwellia blattae	105725	EB105725_05_01430	riboflavin synthase
Solitalea canadensis	15130	Solca_0688	riboflavin synthase, alpha subunit
Sphingobacterium spiritivorum	14948	HMPREF0766_13694	riboflavin synthase, alpha subunit
Sphingobium japonicum	101211	SJA_C1-02920	riboflavin synthase alpha-chain
Sphingobium sp.	103272	SLG_36910	riboflavin synthase alpha chain
Sphingomonas echinoides	15742	SechA1_010100011248	riboflavin synthase subunit alpha
Sphingomonas wittichii	105917	Swit_2444	riboflavin synthase, alpha subunit
Sporichthya polymorpha	12702	Spopo_31_16940	Riboflavin synthase subunit alpha
Stackebrandtia nassauensis	102104	Snas_2597	riboflavin synthase, alpha subunit
Staphylococcus epidermidis	12993	SE_1440	riboflavin synthase alpha chain
Staphylococcus saprophyticus subsp. saprophyticus	102446	SSP0996	riboflavin synthase alpha chain
Starkeya novella	14993	Snov_1655	riboflavin synthase, alpha subunit
Streptococcus equinus	12553	HMPREF0819_0140	riboflavin synthase, alpha subunit
Streptomyces avermitilis	14893	SAV6902	putative riboflavin synthase
Streptomyces cattleya	14057	SCAT_5371	riboflavin synthase (alpha subunit)
Streptomyces clavuligerus	13307	SCLAV_0680	riboflavin synthase subunit alpha
Streptomyces ghanaensis	15414	SSFG_05923	riboflavin synthase subunit alpha
Streptomyces mobaraensis	13819	H340_26741	riboflavin synthase subunit alpha
Streptomyces pristinaespiralis	13074	SSDG_03623	riboflavin synthase subunit alpha
Streptomyces purpureus	13925	STRPU_03_00820	Riboflavin synthase subunit alpha
Streptomyces sviceus	13980	SSEG_09820	riboflavin synthase, alpha subunit
Streptomyces venezuelae	13096	SVEN_1040	Riboflavin synthase alpha chain
Streptosporangium roseum	3776	Sros_2833	Riboflavin synthase
Synechococcus elongatus		Synpcc7942_1624	riboflavin synthase, alpha subunit
Synechocystis sp.		sll0300	riboflavin synthase alpha chain
Thauera linaloolentis	102519	C666_13940	riboflavin synthase subunit alpha
Thermanaerovibrio acidaminovorans		Taci_1009	riboflavin synthase, alpha subunit
Thermobispora bispora	14880	Tbis_1372	riboflavin synthase, alpha subunit
Thermodesulfobacterium commune		HL41_04745	riboflavin synthase subunit alpha
Thermodesulfobium narugense	100082	Thena_1782	riboflavin synthase, alpha subunit
Thermodesulfovibrio yellowstonii		THEYE_A0097	riboflavin synthase, alpha subunit
Thermomicrobium roseum		trd_0503	riboflavin synthase, alpha subunit
Thermomonospora curvata	15933	Tcur_2996	riboflavin synthase, alpha subunit
Thermotoga thermarum	107925	Theth_1644	riboflavin synthase, alpha subunit
Thermus thermophilus	101084	TTHA1063	riboflavin synthase alpha chain
Thermus thermophilus	101085	TT_C0698	riboflavin synthase alpha chain
Tsukamurella paurometabola	16120	Tpau_2562	riboflavin synthase, alpha subunit
Turicella otitidis	106139	HMPREF9719_00718	riboflavin synthase, alpha subunit
Vibrio alginolyticus	15630	N646_0537	riboflavin synthase subunit alpha
Vibrio alginolyticus	15630	N646_2833	Riboflavin synthase alpha chain
Vibrio ichthyoenteri	15847	VII00023_02614	riboflavin synthase subunit alpha
Vibrio ichthyoenteri	15847	VII00023_10894	riboflavin synthase subunit alpha
Vibrio metschnikovii	103153	VIB_000656	riboflavin synthase alpha chain
Vibrio metschnikovii	103153	VIB_001257	lumazine protein
Vibrio orientalis	15638	VIOR3934_14127	riboflavin synthase subunit alpha
Vibrio orientalis	15638	VIOR3934_21551	riboflavin synthase subunit alpha
Vibrio tubiashii	15644	VITU9109_06225	riboflavin synthase subunit alpha
Vibrio tubiashii	15644	VITU9109_11067	lumazine protein
Vibrio vulnificus	15645	B736_02900	riboflavin synthase subunit alpha
Vibrio vulnificus	15645	B736_09075	riboflavin synthase subunit alpha
Weeksella virosa	16016	Weevi_1076	riboflavin synthase, alpha subunit
Xenococcus sp.		Xen7305DRAFT_00031140	riboflavin synthase alpha chain
Xylanimonas cellulosilytica	107835	Xcel_1727	riboflavin synthase, alpha subunit
Yersinia bercovieri	105717	yberc0001_22230	Riboflavin synthase alpha chain
Yersinia rohdei	105715	yrohd0001_27510	Riboflavin synthase alpha chain
Zimmermannella faecalis	15706	G328_10480	hypothetical protein
Zymomonas mobilis subsp. pomaceae	13757	Zymop_0743	riboflavin synthase, alpha subunit