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Rule : GTP cyclohydrolase-2 (RIBA)

Rule Description

ID NRULE_0201
Rule name RIBA
Created 2013-04-09
Protein name
Protein name
Full
GTP cyclohydrolase-2
EC
EC 3.5.4.25
Synonym
Full
GTP cyclohydrolase II
Gene name ribA
Rule Trigger PFAM; PF00925; hit=1
Cross Reference
Gene Ontology
GO
GO:0005525, F:GTP binding, IEA:UniProtKB-KW
GO:0003935, F:GTP cyclohydrolase II activity, IDA:EcoCyc
GO:0008270, F:zinc ion binding, IEA:HAMAP
GO:0009231, P:riboflavin biosynthetic process, IEA:HAMAP
Phylogenomic databases
eggNOG
COG0807, -
HOGENOM
HOG000115442, -
KO
K01497, -
ProtClustDB
PRK00393, -
Enzyme and pathway databases
BioCyc
MetaCyc:GTP-CYCLOHYDRO-II-MONOMER, -
UniPathway
UPA00275, UER00400
Family and domain databases
HAMAP
MF_00179, RibA, 1, -
InterPro
IPR000926, GTP_CycHdrlaseII_RibA
Pfam
PF00925, GTP_cyclohydro2, 1
TIGRFAMs
TIGR00505, ribA, 1
Feature
P0A7I7 Escherichia coli (strain K12).
NP_BIND49 - 53GTP.
NP_BIND92 - 94GTP.
ACT_SITE126Proton acceptor (Potential).
ACT_SITE128Nucleophile.
METAL54Zinc; catalytic.
METAL65Zinc; catalytic.
METAL67Zinc; catalytic.
BINDING70GTP.
BINDING114GTP.
BINDING149GTP.
BINDING154GTP.
General annotation
Function
Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate
Catalytic activity
GTP + 3 H(2)O = formate + 2,5-diamino-6- hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + diphosphate
Cofactor
Binds 1 zinc ion per subunit
Pathway
Cofactor biosynthesis; riboflavin biosynthesis; 5-amino- 6-(D-ribitylamino)uracil from GTP: step 1/4
Subunit structure
Homodimer
Sequence similarities
Belongs to the GTP cyclohydrolase II family
Reference
P0A7I7 Escherichia coli (strain K12).
8320220
Biosynthesis of riboflavin: cloning, sequencing, mapping, and expression of the gene coding for GTP cyclohydrolase II in Escherichia coli. (J Bacteriol. 1993)
9097039
A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map. (DNA Res. 1996)
9278503
The complete genome sequence of Escherichia coli K-12. (Science. 1997)
16738553
Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. (Mol Syst Biol. 2006)
1541275
The aconitase of Escherichia coli. Nucleotide sequence of the aconitase gene and amino acid sequence similarity with mitochondrial aconitases, the iron-responsive-element-binding protein and isopropylmalate isomerases. (Eur J Biochem. 1992)
235552
Purification and properties of guanosine triphosphate cyclohydrolase II from Escherichia coli. (J Biol Chem. 1975)
11301327
Biosynthesis of riboflavin: studies on the mechanism of GTP cyclohydrolase II. (J Biol Chem. 2001)
12392559
Biosynthesis of vitamin B2. (Eur J Biochem. 2002)



Related Function

Function name
Riboflavin biosynthesis

CDS

Data Download
Scientific name NBRC No. CDS Product name
Acaricomes phytoseiuli107788C501_08375hypothetical protein
Acaryochloris marina102967AM1_0608riboflavin biosynthesis protein ribAB (3,4-dihydroxy-2-butanone 4-phosphate synthase and GTP cyclohydrolase II)
Acetobacter aceti14818AaceN1_010100007822bifunctional protein 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Acetobacter pasteurianus105190APA32_18560Bifunctional protein 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Acetobacter pasteurianus101655APT_1569bifunctional protein 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Acetobacter tropicalis101654ATPR_1353bifunctional protein 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Acholeplasma laidlawii14400ACL_1321bifunctional protein: 3,4-dihydroxy-2-butanone 4-phosphate synthase and GTP cyclohydrolase II
Acidimicrobium ferrooxidans103882Afer_1683GTP cyclohydrolase II
Acidiphilium multivorum100883ACMV_236403,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
ACMV_31530GTP cyclohydrolase II
Acidithiobacillus ferrooxidansLferr_04753,4-dihydroxy-2-butanone 4-phosphate synthase
Acidobacterium capsulatum15755ACP_04203,4-dihydroxy-2-butanone 4-phosphate synthase/putative GTP cyclohydrolase II
ACP_0762GTP cyclohydrolase II
Acinetobacter radioresistens102413ACRAD_07_01340GTP cyclohydrolase II
ACRAD_18_005803,4-dihydroxy-2-butanone 4-phosphate synthase
Acinetobacter sp.100985ACT4_019_00570GTP cyclohydrolase II
ACT4_020_003403,4-dihydroxy-2-butanone 4-phosphate synthase
Actinoalloteichus cyanogriseus14455G443_17_00310GTP cyclohydrolase II/3,4-dihydroxy 2-butanone 4-phosphate synthase
Actinoalloteichus spitiensis102582ACTIDRAF_262203,4-dihydroxy-2-butanone 4-phosphate synthase
Actinomadura atramentaria14695G339_091203,4-dihydroxy-2-butanone 4-phosphate synthase
Actinoplanes missouriensis102363AMIS_13360putative GTP cyclohydrolase II
AMIS_50940putative GTP cyclohydrolase II
AMIS_60390putative GTP cyclohydrolase II
AMIS_61940"putative bifunctional GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase"
Actinopolyspora iraqiensis103187ACTIR_363_00030GTP cyclohydrolase II/3,4-dihydroxy 2-butanone 4-phosphate synthase
Actinosynnema mirum14064Amir_3980GTP cyclohydrolase II
Amir_52183,4-dihydroxy-2-butanone 4-phosphate synthase
Aerococcus viridans12219HMPREF0061_14573,4-dihydroxy-2-butanone-4-phosphate synthase
Alicyclobacillus acidocaldarius subsp. acidocaldarius15652Aaci_0938GTP cyclohydrolase II
Alloiococcus otitis15545HMPREF9698_00868GTP cyclohydrolase II
Alteromonas macleodii102226MASE_00675GTP cyclohydrolase II
MASE_124153,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Amycolatopsis azurea14573C791_64333,4-dihydroxy-2-butanone 4-phosphate synthase
C791_69853,4-dihydroxy-2-butanone 4-phosphate synthase
Amycolatopsis mediterranei13415RAM_14095GTP cyclohydrolase II/3,4-dihydroxy 2-butanone 4-phosphate synthase
RAM_16985GTP cyclohydrolase II
RAM_26775GTP cyclohydrolase II
RAM_42865GTP cyclohydrolase II
RAM_46635GTP cyclohydrolase II/3,4-dihydroxy 2-butanone 4-phosphate synthase
Anoxybacillus flavithermus15317Aflv_10173,4-dihydroxy-2-butanone 4-phosphate synthase and GTP cyclohydrolase II
Aquifex aeolicusaq_350GTP cyclohydrolase II
Aquimarina agarilytica107695AagaZ_0201000079693,4-dihydroxy-2-butanone 4-phosphate synthase
Archaeoglobus profundus100127Arcpr_1140GTP cyclohydrolase II
Ardenticatena maritimaARMA_16043,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II
Arthrobacter globiformis12137ARGLB_033_00050GTP cyclohydrolase II
ARGLB_051_00080GTP cyclohydrolase II
Austwickia chelonae105200AUCHE_05_05810GTP cyclohydrolase II
Azorhizobium caulinodans14845AZC_31023,4-dihydroxy-2-butanone 4-phosphate synthase
AZC_4172GTP cyclohydrolase
Bacillus amyloliquefaciens15535BAMF_2225fused GTP cyclohydrolase II and 3,4-dihydroxy-2-butanone 4-phosphate synthase
Bacillus atrophaeus13721BATRMS_17_02760bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein
Bacillus cereus15305BC_3388GTP cyclohydrolase II
BC_4111GTP cyclohydrolase II
Bacillus licheniformis12200BL01889GTP cyclohydrolase II and 3,4-dihydroxy-2-butanone 4-phosphate synthase
Bacillus licheniformis12195BLi02473bifunctional GTP cyclohydrolase II/ 3,4-dihydroxy-2-butanone 4-phosphate synthase RibA
Bacillus mojavensis15718GYU_39_00210bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein
Bacillus mycoides101228bmyco0001_37380GTP cyclohydrolase-2
Bacillus pseudomycoides101232bpmyx0001_359303,4-dihydroxy-2-butanone 4-phosphate synthase
Bacillus psychrosaccharolyticus101233WYK_005_000603,4-dihydroxy-2-butanone 4-phosphate synthase
Bacillus pumilus12092BAT_0977bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
BAT_3398GTP cyclohydrolase II
Bacillus subtilis3134BSU6633_14177bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein
Bacillus subtilis subsp. subtilis13719BSU23260fused GTP cyclohydrolase II and 3,4-dihydroxy-2-butanone 4-phosphate synthase
Bacillus thuringiensis101235bthur0008_30980GTP cyclohydrolase-2
bthur0008_39040GTP cyclohydrolase-2
Bacillus vallismortis101236BvalD_010100002602bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein
Bacteroides vulgatus14291BVU_0143GTP cyclohydrolase II
Balneola vulgarisB155_RS01061153,4-dihydroxy-2-butanone-4-phosphate synthase
Bergeyella zoohelcum16014HMPREF9699_010483,4-dihydroxy-2-butanone-4-phosphate synthase
HMPREF9699_01812GTP cyclohydrolase II
Bradyrhizobium diazoefficiens14792blr26153,4-dihydroxy-2-butanone-4-phoshate synthase/GTP cyclohydrolase II
blr7237probable GTP cyclohydrolase
Brevibacillus brevis100599BBR47_48120riboflavin biosynthesis protein RibA
Brevibacterium linens12170BlinB_010200002257bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein
BlinB_010200017154riboflavin-specific deaminase/GTP cyclohydrolase II
Brevundimonas diminuta12697BDIM_116703,4-dihydroxy-2-butanone 4-phosphate synthase
Brevundimonas subvibrioides16000Bresu_18873,4-dihydroxy-2-butanone 4-phosphate synthase
Caldilinea aerophila104270CLDAP_31590GTP cyclohydrolase-2
Calditerrivibrio nitroreducens101217Calni_1658GTP cyclohydrolase II; 3,4-dihydroxy-2-butanone 4-phosphate synthase
Candidatus Solibacter usitatusAcid_1908GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase
Acid_2182GTP cyclohydrolase II
Catenulispora acidiphila102108Caci_1820GTP cyclohydrolase II
Caci_3108GTP cyclohydrolase II
Caci_3851GTP cyclohydrolase II
Cellulomonas fimi15513Celf_1963GTP cyclohydrolase II
Cellulomonas flavigena3775Cfla_1860GTP cyclohydrolase II
Cellulophaga lytica14961Celly_30373,4-dihydroxy-2-butanone 4-phosphate synthase
Chitinispirillum alkaliphilumCHISP_10063,4-dihydroxy-2-butanone 4-phosphate synthase
Chitinivibrio alkaliphilusCALK_07013,4-dihydroxy-2-butanone 4-phosphate synthase
Chitinophaga pinensis15968Cpin_59343,4-dihydroxy-2-butanone 4-phosphate synthase
Chlamydia trachomatisCTL0100GTP cyclohydrolase II
Chloracidobacterium thermophilum BCabther_A1570GTP cyclohydrolase II
Cabther_B0641GTP cyclohydrolase II
Chlorobaculum tepidum103806CT15913,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Chlorobium limicola103803Clim_19663,4-dihydroxy-2-butanone 4-phosphate synthase
Chromobacterium violaceum12614CV_2005GTP cyclohydrolase II
CV_2389riboflavin biosynthesis bifunctional protein : GTP cyclohydrolase ii and 3,4-dihydroxy-2-butanone-4-phosphate synthase
Chryseobacterium gleum15054HMPREF0204_10102GTP cyclohydrolase II
HMPREF0204_119493,4-dihydroxy-2-butanone-4-phosphate synthase
HMPREF0204_14301GTP cyclohydrolase II
Chrysiogenes arsenatisP304_RS01013803,4-dihydroxy-2-butanone 4-phosphate synthase
P304_RS15475hypothetical protein
Chthoniobacter flavusCfE428DRAFT_46673,4-dihydroxy-2-butanone 4-phosphate synthase
Chthonomonas calidiroseaCCALI_00836GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
Clostridium acetobutylicum13948CA_C0592Riboflavin biosynthes protein RIBA (GTPcyclohydrolase/3,4-dihydroxy-2-butanone 4-phosphate synthase)
Clostridium clariflavum101661Clocl_1126GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
Clostridium kluyveri12016CKR_1902hypothetical protein
Clostridium thermocellum103400Cthe_01063,4-dihydroxy-2-butanone 4-phosphate synthase
Conexibacter woesei100937Cwoe_214334-dihydroxy-2-butanone 4-phosphate synthase
Cwoe_37063,4-dihydroxy-2-butanone 4-phosphate synthase
Cwoe_40213,4-dihydroxy-2-butanone 4-phosphate synthase
Congregibacter litoralis104960KT71_01370GTP cyclohydrolase II
KT71_014003,4-dihydroxy-2-butanone 4-phosphate synthase
KT71_140793,4-dihydroxy-2-butanone 4-phosphate synthase
Coraliomargarita akajimensisCaka_09463,4-dihydroxy-2-butanone 4-phosphate synthase
Corynebacterium ammoniagenes12612HMPREF0281_004633,4-dihydroxy-2-butanone-4-phosphate synthase
Corynebacterium callunae15359H924_07545bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein
Corynebacterium efficiens100395CE17143,4-dihydroxy-2-butanone 4-phosphate synthase
Corynebacterium glutamicum12168Cgl1595GTP cyclohydrolase II
Corynebacterium glutamicum12153KIQ_10042bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein
Corynebacterium striatum15291HMPREF0308_06683,4-dihydroxy-2-butanone-4-phosphate synthase
Corynebacterium terpenotabidum14764A606_05850bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein
Cupriavidus metallidurans102507Rmet_0194GTP cyclohydrolase II
Rmet_2693bifunctional riboflavin biosynthesis protein RibBA: 3,4-dihydroxy-2-butanone-4-phosphate synthase and GTP cyclohydrolase II
Rmet_4572putative GTP cyclohydrolase II
Cystobacter fuscus100088D187_004528GTP cyclohydrolase II like protein
D187_0046053,4-dihydroxy-2-butanone 4-phosphate synthase
D187_009907GTP cyclohydrolase II
Cytophaga hutchinsonii15051CHU_0931GTP cyclohydrolase II
Deferribacter desulfuricans101012DEFDS_1098riboflavin biosynthesis bifunctional protein RibBA
Dehalococcoides mccartyiDehaBAV1_0999GTP cyclohydrolase II
Deinococcus proteolyticus101906Deipr_15953,4-dihydroxy-2-butanone 4-phosphate synthase
Desulfovibrio magneticus104933DMR_046103,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Desulfovibrio vulgaris subsp. vulgaris104121DVU_11993,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Edwardsiella tarda105688ET1_06_00370GTP cyclohydrolase II
Endomicrobium proavitumEpro_05843,4-dihydroxy-2-butanone 4-phosphate synthase
Enterobacter aerogenes13534EAE_21325GTP cyclohydrolase II
Enterobacter cloacae subsp. cloacae13535ECL_01744hypothetical protein
Enterobacter hormaechei105718HMPREF9086_2588GTP cyclohydrolase II
Enterococcus hirae3181EHR_07320GTP cyclohydrolase II
Escherichia coli3972EcolC_2349GTP cyclohydrolase II
Escherichia coli13500WFL_06680GTP cyclohydrolase II
Escherichia coli12713Y75_1264GTP cyclohydrolase II
Escherichia fergusonii102419EFER_1677GTP cyclohydrolase II
Escherichia hermannii105704EH105704_12_00230GTP cyclohydrolase II
Fibrobacter succinogenesFisuc_2736GTP cyclohydrolase II
Fimbriimonas ginsengisoliOP10G_23013,4-dihydroxy-2-butanone 4-phosphate synthase
Fischerella sp.PCC9339_RS01147503,4-dihydroxy-2-butanone 4-phosphate synthase
PCC9339_RS0133910hypothetical protein
Flavobacterium johnsoniae14942Fjoh_21093,4-dihydroxy-2-butanone 4-phosphate synthase
Flexibacter litoralis15988Fleli_3848GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
Fluviicola taffensis106335Fluta_3460GTP cyclohydrolase II
Fusobacterium nucleatum subsp. NucleatumFN1508GTP cyclohydrolase II
Gemmata obscuriglobusGEMOB_RS077453,4-dihydroxy-2-butanone 4-phosphate synthase
Gemmatimonas aurantiaca100505GAU_14733,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Geodermatophilus obscurus13315Gobs_3111GTP cyclohydrolase II
Gloeobacter violaceusglr0988riboflavin biosynthesis protein
Gluconacetobacter hansenii14816GXY_004193,4-dihydroxy-2-butanone 4-phosphate synthase
Gluconobacter frateurii101659GfraN1_0101000064263,4-Dihydroy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Gordonia aichiensis108223GOACH_05_01980riboflavin biosynthesis protein RibBA
GOACH_18_00910putative GTP cyclohydrolase II
Gordonia alkanivorans16433GOALK_017_00310riboflavin biosynthesis protein RibBA
GOALK_029_00020putative GTP cyclohydrolase II
GOALK_033_01240riboflavin biosynthesis protein RibBA
GOALK_079_00020riboflavin biosynthesis protein RibBA
Gordonia amarae15530GOAMR_03_00650riboflavin biosynthesis protein RibBA
GOAMR_03_01280putative GTP cyclohydrolase II
Gordonia amicalis100051GOAMI_01_01270GTP cyclohydrolase II
GOAMI_13_00680putative GTP cyclohydrolase II
GOAMI_17_00660riboflavin biosynthesis protein ribBA
GOAMI_50_00170GTP cyclohydrolase II
Gordonia araii100433GOARA_064_00430GTP cyclohydrolase-2
Gordonia bronchialis16047Gbro_16933,4-dihydroxy-2-butanone 4-phosphate synthase
Gbro_2355GTP cyclohydrolase II
Gbro_2716conserved hypothetical protein
Gordonia effusa100432GOEFS_049_00260riboflavin biosynthesis protein RibBA
Gordonia hirsuta16056GOHSU_18_00680riboflavin biosynthesis protein RibBA
Gordonia namibiensis108229GONAM_02_02300putative GTP cyclohydrolase II
GONAM_10_02400riboflavin biosynthesis protein RibBA
GONAM_12_00470riboflavin biosynthesis protein RibBA
GONAM_55_00030GTP cyclohydrolase II
Gordonia otitidis100426GOOTI_048_00130riboflavin biosynthesis protein RibBA
GOOTI_257_00060putative GTP cyclohydrolase II
Gordonia polyisoprenivorans16320GOPIP_009_00040putative GTP cyclohydrolase II
GOPIP_029_00160riboflavin biosynthesis protein RibBA
GOPIP_056_00850riboflavin biosynthesis protein RibBA
GOPIP_067_00690riboflavin biosynthesis protein RibBA
Gordonia rhizosphera16068GORHZ_026_00120riboflavin biosynthesis protein RibBA
GORHZ_060_00080putative GTP cyclohydrolase II
GORHZ_085_00320GTP cyclohydrolase II
GORHZ_090_00140riboflavin biosynthesis protein RibBA
GORHZ_121_00230riboflavin biosynthesis protein RibBA
GORHZ_125_01200riboflavin biosynthesis protein RibBA
Gordonia rubripertincta101908GORBP_023_00020riboflavin biosynthesis protein RibBA
GORBP_039_01280riboflavin biosynthesis protein RibBA
GORBP_062_00060putative GTP cyclohydrolase II
Gordonia sihwensis108236GSI01S_03_00390riboflavin biosynthesis protein RibBA
Gordonia soli108243GS4_18_00660riboflavin biosynthesis protein RibBA
Gordonia sputi100414GOSPT_022_00650riboflavin biosynthesis protein RibBA
GOSPT_085_00180putative GTP cyclohydrolase II
Gordonia terrae100016GOTRE_001_01500putative GTP cyclohydrolase II
GOTRE_019_00080riboflavin biosynthesis protein RibBA
GOTRE_081_00470riboflavin biosynthesis protein RibBA
GOTRE_125_01110riboflavin biosynthesis protein RibBA
GOTRE_150_00310GTP cyclohydrolase II
Halobacillus halophilus102448HBHAL_4679bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase / GTP cyclohydrolase II protein
Halomonas elongata15536HELO_1088GTP cyclohydrolase II
HELO_3590bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein
Haloplasma contractileHLPCO_001293GTP cyclohydrolase II protein
Herpetosiphon aurantiacusHaur_13063,4-dihydroxy-2-butanone 4-phosphate synthase
Holophaga foetidaHOLFODRAFT_RS02077903,4-dihydroxy-2-butanone 4-phosphate synthase
HOLFODRAFT_RS0208585GTP cyclohydrolase
Hylemonella gracilis14920HGR_095033,4-dihydroxy-2-butanone 4-phosphate synthase
HGR_11381hypothetical protein
Hyphomonas neptunium14232HNE_2056riboflavin biosynthesis protein RibA
Ignavibacterium album101810IALB_21053,4-dihydroxy 2-butanone 4-phosphate synthase
Intrasporangium calvum12989Intca_1032GTP cyclohydrolase II
Intca_1623GTP cyclohydrolase II; 3,4-dihydroxy-2-butanone 4-phosphate synthase
Jonesia denitrificans15587Jden_06823,4-dihydroxy-2-butanone 4-phosphate synthase
Kineococcus radiotolerans101839Krad_0125GTP cyclohydrolase II
Kineosphaera limosa100340KILIM_040_00170GTP cyclohydrolase II
Kitasatospora setae14216KSE_11600putative 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
KSE_59160putative GTP cyclohydrolase II
KSE_64690putative GTP cyclohydrolase II
Klebsiella pneumoniae14438KPR_2325
Klebsiella pneumoniae subsp. rhinoscleromatis105682HMPREF0484_3158GTP cyclohydrolase II
Kocuria rhizophila103217KRH_11710GTP cyclohydrolase II
Kordia algicida100336KAOT1_04560bifunctional protein: GTP cyclohydrolase II; 3,4 dihydroxy-2-butanone-4-phosphate synthase
Kribbella flavida14399Kfla_51343,4-dihydroxy-2-butanone 4-phosphate synthase
Ktedonobacter racemiferKrac_1421GTP cyclohydrolase II
Krac_1701GTP cyclohydrolase II
Krac_21543,4-dihydroxy-2-butanone 4-phosphate synthase
Kyrpidia tusciae15312Btus_18243,4-dihydroxy-2-butanone 4-phosphate synthase
Kytococcus sedentarius15357Ksed_015703,4-dihydroxy-2-butanone 4-phosphate synthase
Labrenzia aggregata16684SIAM614_06963GTP cyclohydrolase II
Lactobacillus farciminis107150LfarK3_010100008236GTP cyclohydrolase II
Lactobacillus fermentum15885HMPREF0511_07763,4-dihydroxy-2-butanone-4-phosphate synthase
Lactobacillus fermentum3956LAF_0774GTP cyclohydrolase II
Lactobacillus plantarum subsp. plantarum15891HMPREF0531_10516GTP cyclohydrolase II
Lactobacillus reuteri15892LAR_0826GTP cyclohydrolase II
Leadbetterella byssophila106382Lbys_1704GTP cyclohydrolase II
Lentisphaera araneosaLNTAR_18108bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein
LNTAR_181133,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Leptospira interrogansLA_1147bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Leuconostoc lactis107866EY7_758_000603,4-dihydroxy-2-butanone 4-phosphate synthase
Leuconostoc mesenteroides subsp. mesenteroides100496LEUM_0824GTP cyclohydrolase II
Leuconostoc pseudomesenteroides107767LpseK3_010100008066GTP cyclohydrolase II
Limnochorda pilosa110152LIP_33013,4-dihydroxy-2-butanone 4-phosphate synthase
Magnetospirillum gryphiswaldense15271MGR_2751GTP cyclohydrolase II
MGR_2800bifunctional GTP cyclohydrolase II/3,4-dihydroxy-2butanone-4-phosphate synthase
Magnetospirillum magnetotacticum15272Magn03005825COG0807: GTP cyclohydrolase II
Magn03009110COG0108: 3,4-dihydroxy-2-butanone 4-phosphate synthase
Magn03009111COG0807: GTP cyclohydrolase II
Magn03010469COG0807: GTP cyclohydrolase II
Marinomonas mediterranea103028Marme_04993,4-dihydroxy-2-butanone 4-phosphate synthase
Marme_2059GTP cyclohydrolase-2
Mariprofundus ferrooxydansSPV1_017073,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Marivirga tractuosa15989Ftrac_0930GTP cyclohydrolase II
Meiothermus ruber106122Mrub_1253GTP cyclohydrolase II
Meiothermus silvanus106475Mesil_3464hypothetical protein
Methylacidiphilum infernorumMinf_24303,4-dihydroxy-2-butanone 4-phosphate synthase and GTP cyclohydrolase II
Methylobacterium radiotolerans15690Mrad2831_27553,4-dihydroxy-2-butanone 4-phosphate synthase
Micrococcus luteus3333Mlut_10870GTP cyclohydrolase II /3,4-dihydroxy-2-butanone 4-phosphate synthase
Microlunatus phosphovorus101784MLP_01300GTP cyclohydrolase II
Micromonospora aurantiaca16155Micau_23593,4-dihydroxy-2-butanone 4-phosphate synthase
Micau_3610GTP cyclohydrolase II
Microscilla marina16560M23134_08222riboflavin biosynthesis protein ribAB
Mobilicoccus pelagius104925MOPEL_130_01580GTP cyclohydrolase II
Myroides odoratus14945Myrod_27203,4-dihydroxy-2-butanone 4-phosphate synthase
Nakamurella multipartita105858Namu_41513,4-dihydroxy-2-butanone 4-phosphate synthase
Niastella koreensis106392Niako_0400GTP cyclohydrolase-2
Nitriliruptor alkaliphilusNitalDRAFT_24993,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II
NitalDRAFT_34233,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II
Nitrosomonas europaea14298NE2556ribAB; riboflavin biosynthesis bifunctional protein: GTP cyclohydrolase II and 3,4-dihydroxy-2-butanone-4-phosphate synthase
Nitrospina gracilisNITGR_910039Riboflavin biosynthesis protein RibBA
Nocardiopsis dassonvillei14626Ndas_08613,4-dihydroxy-2-butanone 4-phosphate synthase
Nostoc sp.all3536GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase
Oceanithermus profundus100410Ocepr_1717GTP cyclohydrolase II; 3,4-dihydroxy-2-butanone 4-phosphate synthase
Ochrobactrum anthropi15819Oant_05403,4-dihydroxy-2-butanone 4-phosphate synthase
Ochrobactrum intermedium15820OINT_10004803,4-dihydroxy-2-butanone 4-phosphate synthase
Oscillibacter valericigenes101213OBV_012503,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Paenibacillus alvei3343PAV_1c08520GTP cyclohydrolase-2
PAV_3c05350riboflavin biosynthesis protein RibBA
Paenibacillus peoriae15541PpeoK3_010100008891GTP cyclohydrolase II
Paenibacillus polymyxa15309PPT_23650GTP cyclohydrolase
Pedobacter heparinus12017Phep_35613,4-dihydroxy-2-butanone 4-phosphate synthase
Pedobacter saltans100064Pedsa_0362GTP cyclohydrolase II
Pelobacter carbinolicus103641Pcar_14473,4-dihydroxy-2-butanone-4-phosphate synthase and GTP cyclohydrolase II
Pelobacter propionicus103807Ppro_16523,4-dihydroxy-2-butanone 4-phosphate synthase
Phaeobacter gallaeciensis16654PGA1_c089203,4-dihydroxy-2-butanone 4-phosphate synthase RibB
PGA1_c33340putative GTP cyclohydrolase-2
Photobacterium damselae subsp. damselae corrig.15633VDA_002191GTP cyclohydrolase II
VDA_0026793,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Phycisphaera mikurensis102666PSMK_00420putative 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Picrophilus torridus100828PTO0570GTP cyclohydrolase II
Planctomyces brasiliensis103401Plabr_4695GTP cyclohydrolase II
Prochlorococcus marinus subsp. marinusPro_09433,4-dihydroxy-2-butanone 4-phosphate synthase
Propionibacterium acidipropionici12425PACID_246503,4-dihydroxy-2-butanone-4-phosphate synthase
Propionibacterium avidum15671HMPREF9153_0359riboflavin biosynthesis protein ribBA
Proteus mirabilis105697HMPREF0693_0892GTP cyclohydrolase II
Providencia alcalifaciens105687PROVALCAL_02828GTP cyclohydrolase II
Pseudomonas putida100650PP_05163,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
PP_0522GTP cyclohydrolase II
PP_38133,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Pseudomonas stutzeri14165PSTAB_0724bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein
PSTAB_0730GTP cyclohydrolase II
Rahnella aquatilis105701Rahaq2_2075GTP cyclohydrolase II
Renibacterium salmoninarum15589RSal33209_2345GTP cyclohydrolase II
Rhizobium etli15573RHE_PD00121GTP cyclohydrolase II protein
Rhizobium sp.101917NGR_c05210riboflavin biosynthesis protein
Rhizobium tropici15247RTCIAT899_CH04470riboflavin biosynthesis protein ribBA
Rhodobacter capsulatus16581RCAP_rcc00262GTP cyclohydrolase II
RCAP_rcc030753,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Rhodobacter sphaeroides12203RSP_0757GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase
RSP_0846GTP cyclohydrolase II
Rhodococcus erythropolis100887RER_30220riboflavin biosynthesis bifunctional protein RibA
Rhodococcus opacus108011ROP_03890putative GTP cyclohydrolase II
ROP_13740GTP cyclohydrolase II
ROP_337303,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
ROP_466003,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
ROP_695103,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Roseobacter denitrificans15277RD1_0043GTP cyclohydrolase II
RD1_18013,4-dihydroxy-2-butanone 4-phosphate synthase
Roseobacter litoralis15278RLO149_c029170riboflavin biosynthesis protein
RLO149_c039330GTP cyclohydrolase II
Rothia dentocariosa12531HMPREF0733_11816putative GTP cyclohydrolase II
Rothia mucilaginosa15673ROTMU0001_0384putative GTP cyclohydrolase II
Rubrobacter xylanophilus100952Rxyl_0381GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase
Rxyl_1366GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase
Rxyl_1780GTP cyclohydrolase II
Saccharomonospora azurea14651SacazDRAFT_00051GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
Saccharomonospora cyanea14841SaccyDRAFT_1937GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
Saccharomonospora glauca14831SacglDRAFT_01790GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
Saccharomonospora viridis12207Svir_15730GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
Saccharopolyspora erythraea13426SACE_21233,4-dihydroxy-2-butanone 4-phosphate synthase
SACE_278634-dihydroxy-2-butanone 4-phosphate synthase
SACE_2884GTP cyclohydrolase II
Saccharopolyspora spinosa15153SspiN1_0101000264393,4-dihydroxy-2-butanone 4-phosphate synthase
SspiN1_0101000278593,4-dihydroxy-2-butanone 4-phosphate synthase
SspiN1_010100036704bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein
SspiN1_0101000374493,4-dihydroxy-2-butanone 4-phosphate synthase
SspiN1_0101000376643,4-dihydroxy-2-butanone 4-phosphate synthase
Saccharothrix espanaensis15066BN6_41270putative dihydroxybutanonphosphate synthase/GTP-cyclohydrolase II
BN6_62920Riboflavin biosynthesis protein ribBA
Salinibacter ruberSRU_00123,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
SRU_1510riboflavin-specific deaminase/GTP cyclohydrolase II
Salinispora arenicola105043Q5S_1272_00010GTP cyclohydrolase II/3,4-dihydroxy 2-butanone 4-phosphate synthase
Q5S_1850_00030GTP cyclohydrolase II
Salinispora tropica105044Strop_1877GTP cyclohydrolase II
Strop_2559GTP cyclohydrolase II
Sanguibacter keddieii16158Sked_18160GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
Selenomonas ruminantium subsp. lactilytica103574SELR_09870putative riboflavin biosynthesis protein RibBA
Serratia odorifera102598HMPREF0758_3564GTP cyclohydrolase II
Shimwellia blattae105725EB105725_19_00220GTP cyclohydrolase II
Solitalea canadensis15130Solca_0222GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
Sphingobacterium spiritivorum14948HMPREF0766_123873,4-dihydroxy-2-butanone-4-phosphate synthase
Sphingobium japonicum101211SJA_C1-02930GTP cyclohydrolase II
SJA_C1-35060GTP cyclohydrolase II
SJA_C2-03830GTP cyclohydrolase II
Sphingobium sp.103272SLG_02010GTP cyclohydrolase II
SLG_368903,4-dihydroxy-2-butanone 4-phosphate synthase
Sphingomonas echinoides15742SechA1_0101000006203,4-dihydroxy-2-butanone 4-phosphate synthase
SechA1_0101000112533,4-dihydroxy-2-butanone 4-phosphate synthase
SechA1_010100011543GTP cyclohydrolase
Sphingomonas wittichii105917Swit_10043,4-dihydroxy-2-butanone 4-phosphate synthase
Swit_24453,4-dihydroxy-2-butanone 4-phosphate synthase
Swit_37713,4-dihydroxy-2-butanone 4-phosphate synthase
Swit_3789GTP cyclohydrolase II
Sporichthya polymorpha12702Spopo_31_16950GTP cyclohydrolase II
Stackebrandtia nassauensis102104Snas_25983,4-dihydroxy-2-butanone 4-phosphate synthase
Staphylococcus epidermidis12993SE_1439riboflavin biosynthesis protein
Staphylococcus saprophyticus subsp. saprophyticus102446SSP0997riboflavin biosynthesis protein
Starkeya novella14993Snov_0099GTP cyclohydrolase II
Snov_44473,4-dihydroxy-2-butanone 4-phosphate synthase
Streptococcus equinus12553HMPREF0819_01413,4-dihydroxy-2-butanone-4-phosphate synthase
Streptomyces avermitilis14893SAV0545putative GTP cyclohydrolase II
SAV1791putative GTP cyclohydrolase II
SAV4121putative GTP cyclohydrolase II
SAV6904putative GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
Streptomyces cattleya14057SCAT_5373fused GTP cyclohydrolase II and 3, 4-dihydroxy-2-butanone 4-phosphate synthase
Streptomyces clavuligerus13307SCLAV_06783,4-dihydroxy-2-butanone 4-phosphate synthase
Streptomyces ghanaensis15414SSFG_01135GTP cyclohydrolase-2
SSFG_059253,4-dihydroxy-2-butanone 4-phosphate synthase
Streptomyces mobaraensis13819H340_26731bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein
Streptomyces pristinaespiralis13074SSDG_036243,4-dihydroxy-2-butanone 4-phosphate synthase
Streptomyces purpureus13925STRPU_03_008003,4-dihydroxy-2-butanone 4-phosphate synthase or GTP cyclohydrolase II
Streptomyces sviceus13980SSEG_02892GTP cyclohydrolase II
SSEG_07766GTP cyclohydrolase II
SSEG_098183,4-dihydroxy-2-butanone 4-phosphate synthase
Streptomyces venezuelae13096SVEN_10383,4-dihydroxy-2-butanone 4-phosphate synthase or GTP cyclohydrolase II
Streptosporangium roseum3776Sros_2835conserved hypothetical protein
Synechococcus elongatusSynpcc7942_1432GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase
Synechocystis sp.sll1894GTP cyclohydrolase II
Thauera linaloolentis102519C666_12435GTP cyclohydrolase II
C666_13935bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein
Thermanaerovibrio acidaminovoransTaci_10083,4-dihydroxy-2-butanone 4-phosphate synthase
Thermobispora bispora14880Tbis_13743,4-dihydroxy-2-butanone 4-phosphate synthase
Thermodesulfobacterium communeHL41_002453,4-dihydroxy-2-butanone 4-phosphate synthase
Thermodesulfobium narugense100082Thena_1542GTP cyclohydrolase-2
Thermodesulfovibrio yellowstoniiTHEYE_A0208riboflavin biosynthesis protein RibA
Thermomicrobium roseumtrd_0504riboflavin biosynthesis protein ribA
Thermomonospora curvata15933Tcur_29953,4-dihydroxy-2-butanone 4-phosphate synthase
Thermotoga maritima100826TM_1826GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
Thermotoga naphthophila104846Tnap_1001GTP cyclohydrolase II
Thermotoga neapolitana107923CTN_0758Riboflavin biosynthesis protein ribBA
Thermotoga petrophila104847Tpet_1111GTP cyclohydrolase II
Thermotoga thermarum107925Theth_1645GTP cyclohydrolase II
Thermus thermophilus101084TTHA1062GTP cyclohydrolase II/3,4-dihydroxy-2-butanone-4-phosphate synthase
Thermus thermophilus101085TT_C0697GTP cyclohydrolase II/3,4-dihydroxy-2-butanone-4-phosphate synthase
Tsukamurella paurometabola16120Tpau_2561GTP cyclohydrolase II
Turicella otitidis106139HMPREF9719_00717GTP cyclohydrolase II
Vibrio alginolyticus15630N646_1002GTP cyclohydrolase II
N646_28343,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
N646_3470GTP cyclohydrolase II
Vibrio ichthyoenteri15847VII00023_026093,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
VII00023_07144GTP cyclohydrolase II
Vibrio metschnikovii103153VIB_0006573,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
VIB_001377GTP cyclohydrolase II
Vibrio orientalis15638VIOR3934_05004GTP cyclohydrolase II
VIOR3934_141223,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
VIOR3934_19055GTP cyclohydrolase II
Vibrio tubiashii15644VITU9109_06220GTP cyclohydrolase II
VITU9109_22396GTP cyclohydrolase II
Vibrio vulnificus15645B736_02170GTP cyclohydrolase
B736_090803,4-dihydroxy-2-butanone 4-phosphate synthase
B736_14885GTP cyclohydrolase
Weeksella virosa16016Weevi_07613,4-dihydroxy-2-butanone 4-phosphate synthase
Xenococcus sp.Xen7305DRAFT_00032940GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
Xylanimonas cellulosilytica107835Xcel_1728GTP cyclohydrolase II
Yersinia bercovieri105717yberc0001_36490GTP cyclohydrolase-2
Yersinia rohdei105715yrohd0001_32480GTP cyclohydrolase-2
Zimmermannella faecalis15706G328_04475hypothetical protein
Zymomonas mobilis subsp. pomaceae13757Zymop_07443,4-dihydroxy-2-butanone 4-phosphate synthase
Zymop_1420GTP cyclohydrolase II