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Rule : Dihydropteroate synthase (DHPS)

Rule Description

ID NRULE_0144
Rule name DHPS
Created 2013-02-20
Protein name
Protein name
Full
Dihydropteroate synthase
Short
DHPS
EC
EC 2.5.1.15
Synonym
Full
Dihydropteroate pyrophosphorylase
Gene name folP
Rule Trigger TIGRFAMs; TIGR01496; hit=1
Cross Reference
Gene Ontology
GO
GO:0004156, F:dihydropteroate synthase activity, IDA:MTBBASE
GO:0046872, F:metal ion binding, IEA:UniProtKB-KW
GO:0046656, P:folic acid biosynthetic process, IEA:UniProtKB-KW
GO:0046677, P:response to antibiotic, IEA:UniProtKB-KW
GO:0046654, P:tetrahydrofolate biosynthetic process, IEA:UniProtKB-UniPathway
Phylogenomic databases
KO
K00796, -
Family and domain databases
InterPro
IPR006390, DHP_synth
IPR000489, Pterin-binding
Pfam
PF00809, Pterin_bind, 1
TIGRFAMs
TIGR01496, DHPS, 1
PROSITE
PS00792, DHPS_1, 1
PS00793, DHPS_2, 1
PS50972, PTERIN_BINDING, 1
Feature
P0AC13 Escherichia coli (strain K12).
METAL22Magnesium.
BINDING30Substrate.
BINDING96Substrate.
BINDING115Substrate.
BINDING185Substrate.
BINDING221Substrate.
BINDING255Substrate.
BINDING257Substrate.
General annotation
Function
DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide
Catalytic activity
(2-amino-4-hydroxy-7,8-dihydropteridin-6- yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate
Cofactor
Binds 1 magnesium ion per subunit. Magnesium is required for activity, even if it interacts primarily with the substrate
Pathway
Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8- dihydropteridine diphosphate and 4-aminobenzoate: step 1/2
Subunit structure
Homodimer or homotrimer
Sequence similarities
Belongs to the DHPS family
Contains 1 pterin-binding domain
Reference
P0AC13 Escherichia coli (strain K12).
1522070
Cloning, sequencing, and enhanced expression of the dihydropteroate synthase gene of Escherichia coli MC4100. (J Bacteriol. 1992)
P0A578 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh). Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
10542185
Cloning and expression of Mycobacterium tuberculosis and Mycobacterium leprae dihydropteroate synthase in Escherichia coli. (J Bacteriol. 1999)
P0C002 Escherichia coli.
3054482
Site-specific recombination promotes linkage between trimethoprim- and sulfonamide resistance genes. Sequence characterization of dhfrV and sulI and a recombination active locus of Tn21. (Mol Gen Genet. 1988)



Related Function

Function name
Folate biosynthesis

CDS

Data Download
Scientific name NBRC No. CDS Product name
Acaricomes phytoseiuli107788C501_03655dihydropteroate synthase
Acaryochloris marina102967AM1_0188dihydropteroate synthase
Acetobacter aceti14818AaceN1_010100011353dihydropteroate synthase
Acetobacter pasteurianus105190APA32_26150Dihydropteroate synthase
Acetobacter pasteurianus101655APT_0687dihydropteroate synthase
Acetobacter tropicalis101654ATPR_1132dihydropteroate synthase
Acidimicrobium ferrooxidans103882Afer_1304dihydropteroate synthase
Afer_1911dihydropteroate synthase
Acidiphilium multivorum100883ACMV_10970dihydropteroate synthase
Acidithiobacillus ferrooxidansLferr_2261dihydropteroate synthase
Acidobacterium capsulatum15755ACP_2249dihydropteroate synthase
Acinetobacter radioresistens102413ACRAD_59_000207,8-dihydropteroate synthase
Acinetobacter sp.100985ACT4_037_00170dihydropteroate synthase
Actinoalloteichus cyanogriseus14455G443_01_03600dihydropteroate synthase
G443_06_00380dihydropteroate synthase
Actinoalloteichus spitiensis102582ACTIDRAF_08725hypothetical protein
ACTIDRAF_12595Inactive dihydropteroate synthase 2
Actinomadura atramentaria14695G339_15265dihydropteroate synthase
G339_23145hypothetical protein
Actinoplanes missouriensis102363AMIS_50270putative dihydropteroate synthase
AMIS_77880putative dihydropteroate synthase
Actinosynnema mirum14064Amir_0315dihydropteroate synthase
Amir_0777dihydropteroate synthase
Aerococcus viridans12219HMPREF0061_0617dihydropteroate synthase
Alicyclobacillus acidocaldarius subsp. acidocaldarius15652Aaci_0205dihydropteroate synthase
Alloiococcus otitis15545HMPREF9698_00476dihydropteroate synthase
Alteromonas macleodii102226MASE_08685dihydropteroate synthase
Amycolatopsis azurea14573C791_0614Non functional Dihydropteroate synthase 2
C791_0695Dihydropteroate synthase
Amycolatopsis mediterranei13415RAM_06870dihydropteroate synthase
RAM_19760dihydropteroate synthase
RAM_37020dihydropteroate synthase
RAM_44875dihydropteroate synthase
Anoxybacillus flavithermus15317Aflv_0069Dihydropteroate synthase
Aquifex aeolicusaq_1468dihydropteroate synthase
Aquimarina agarilytica107695AagaZ_020100011944dihydropteroate synthase
Arcanobacterium haemolyticum15585Arch_0253dihydropteroate synthase
Ardenticatena maritimaARMA_1896dihydropteroate synthase
Arthrobacter globiformis12137ARGLB_032_00350dihydropteroate synthase
Atopobium rimae15546ATORI0001_1446dihydropteroate synthase
Austwickia chelonae105200AUCHE_03_01710dihydropteroate synthase
Azorhizobium caulinodans14845AZC_1218dihydropteroate synthase
Bacillus amyloliquefaciens15535BAMF_0077dihydropteroate synthase
Bacillus atrophaeus13721BATRMS_24_00540dihydropteroate synthase
Bacillus cereus15305BC_0079Dihydropteroate synthase
Bacillus licheniformis12200BL00861dihydropteroate synthase
Bacillus licheniformis12195BLi00093dihydropteroate synthase Sul
Bacillus mojavensis15718GYU_04_02780dihydropteroate synthase
Bacillus mycoides101228bmyco0001_590Dihydropteroate synthase
Bacillus pseudomycoides101232bpmyx0001_590Dihydropteroate synthase
Bacillus psychrosaccharolyticus101233WYK_203_00060dihydropteroate synthase
Bacillus pumilus12092BAT_4072dihydropteroate synthase
Bacillus subtilis3134BSU6633_00660dihydropteroate synthase
Bacillus subtilis subsp. subtilis13719BSU00770dihydropteroate synthase
Bacillus thuringiensis101235bthur0008_610Dihydropteroate synthase
Bacteroides vulgatus14291BVU_0517dihydropteroate synthase
Balneola vulgarisB155_RS0105945dihydropteroate synthase
Bergeyella zoohelcum16014HMPREF9699_01216dihydropteroate synthase
Beutenbergia cavernae16432Bcav_0704dihydropteroate synthase
Bradyrhizobium diazoefficiens14792bll3059probable dihydropteroate synthase (EC 2.5.1.15)
Brevibacillus brevis100599BBR47_01760dihydropteroate synthase
Brevibacterium linens12170BlinB_010200002102dihydropteroate synthase
BlinB_010200013908dihydropteroate synthase
Brevundimonas diminuta12697BDIM_03270dihydropteroate synthase
Brevundimonas subvibrioides16000Bresu_0870dihydropteroate synthase
Caldanaerobacter subterraneus subsp. tengcongensis100824TTE2370Dihydropteroate synthase
Caldisericum exile104410CSE_04190dihydropteroate synthase
Calditerrivibrio nitroreducens101217Calni_1444dihydropteroate synthase
Candidatus Korarchaeum cryptofilumKcr_0833dihydropteroate synthase
Candidatus Nitrosopumilus sp.NSED_00655dihydropteroate synthase
Candidatus Solibacter usitatusAcid_6708Dihydropteroate synthase
Catenulispora acidiphila102108Caci_7946dihydropteroate synthase
Caci_8423dihydropteroate synthase
Caulobacter segnis15250Cseg_0695dihydropteroate synthase
Cellulomonas fimi15513Celf_0561dihydropteroate synthase
Celf_2887dihydropteroate synthase
Cellulomonas flavigena3775Cfla_0629dihydropteroate synthase
Cfla_1001dihydropteroate synthase
Cellulophaga lytica14961Celly_2320dihydropteroate synthase
Cenarchaeum symbiosumCENSYa_2007dihydropteroate synthase
Chitinispirillum alkaliphilumCHISP_3342Dihydropteroate synthase
Chitinivibrio alkaliphilusCALK_0582dihydropteroate synthase
Chitinophaga pinensis15968Cpin_5465dihydropteroate synthase
Chlamydia trachomatisCTL08772-amino-4-hydroxy-6-hydroxymethyldihydropteridi ne pyrophosphokinase
Chloracidobacterium thermophilum BCabther_A0328Dihydropteroate synthase
Chlorobaculum tepidum103806CT1706dihydropteroate pyrophosphorylase
Chlorobium limicola103803Clim_1985dihydropteroate synthase
Chromobacterium violaceum12614CV_3796dihydropteroate synthase
Chryseobacterium gleum15054HMPREF0204_14707dihydropteroate synthase
Chrysiogenes arsenatisP304_RS13210hypothetical protein
Chthoniobacter flavusCfE428DRAFT_3030dihydropteroate synthase
CfE428DRAFT_4935dihydropteroate synthase
Chthonomonas calidiroseaCCALI_02063Dihydropteroate synthase
Clostridium acetobutylicum13948CA_C2926Dihydropteroate synthase
Clostridium clariflavum101661Clocl_4043Dihydropteroate synthase
Clostridium kluyveri12016CKR_0865hypothetical protein
Clostridium thermocellum103400Cthe_2581dihydropteroate synthase
Conexibacter woesei100937Cwoe_1674dihydropteroate synthase
Cwoe_3796dihydropteroate synthase
Congregibacter litoralis104960KT71_07974Dihydropteroate synthase
Coraliomargarita akajimensisCaka_2395dihydropteroate synthase
Corynebacterium ammoniagenes12612HMPREF0281_01494dihydropteroate synthase
HMPREF0281_01962dihydropteroate synthase
Corynebacterium callunae15359H924_05235dihydropteroate synthase
H924_11295dihydropteroate synthase
Corynebacterium efficiens100395CE1168putative dihydropteroate synthase
CE2540dihydropteroate synthase
Corynebacterium glutamicum12168Cgl1111Dihydropteroate synthase
Cgl2694Dihydropteroate synthase
Corynebacterium glutamicum12153KIQ_12255dihydropteroate synthase
KIQ_15602dihydropteroate synthase
Corynebacterium matruchotii15360HMPREF0299_7531dihydropteroate synthase
Corynebacterium striatum15291HMPREF0308_0047dihydropteroate synthase
HMPREF0308_2213dihydropteroate synthase
Corynebacterium terpenotabidum14764A606_01955dihydropteroate synthase
Cupriavidus metallidurans102507Rmet_21877,8-dihydropteroate synthase
Cystobacter fuscus100088D187_007108Dihydropteroate synthase
Cytophaga hutchinsonii15051CHU_3223Dihydropteroate synthase
Deferribacter desulfuricans101012DEFDS_1030dihydropteroate synthase
Dehalococcoides mccartyiDehaBAV1_1349Dihydropteroate synthase
Deinococcus proteolyticus101906Deipr_1896dihydropteroate synthase
Desulfovibrio magneticus104933DMR_25730dihydropteroate synthase
Desulfovibrio vulgaris subsp. vulgaris104121DVU_1279dihydropteroate synthase
Dictyoglomus turgidumDtur_0616dihydropteroate synthase
Edwardsiella tarda105688ET1_14_01240dihydropteroate synthase
Elusimicrobium minutumEmin_0633Dihydropteroate synthase
Endomicrobium proavitumEpro_0866Dihydropteroate synthase
Enterobacter aerogenes13534EAE_04320dihydropteroate synthase
Enterobacter cloacae subsp. cloacae13535ECL_03814dihydropteroate synthase
ECL_04556dihydropteroate synthase
Enterobacter hormaechei105718HMPREF9086_4036dihydropteroate synthase
Enterococcus haemoperoxidus100709I583_00583dihydropteroate synthase
Enterococcus pallens100697I588_03232dihydropteroate synthase
Escherichia coli3972EcolC_0523dihydropteroate synthase
Escherichia coli13500WFL_16870dihydropteroate synthase
Escherichia coli12713Y75_31377,8-dihydropteroate synthase
Escherichia fergusonii102419EFER_31547,8-dihydropteroate synthase
Escherichia hermannii105704EH105704_02_01930dihydropteroate synthase
Fibrobacter succinogenesFisuc_2777dihydropteroate synthase
Fimbriimonas ginsengisoliOP10G_3388dihydropteroate synthase
Finegoldia magnaFMG_0881dihydropteroate synthase
Fischerella sp.PCC9339_RS0120915dihydropteroate synthase
Flavobacterium johnsoniae14942Fjoh_3497Dihydropteroate synthase
Flexibacter litoralis15988Fleli_1514dihydropteroate synthase
Fluviicola taffensis106335Fluta_3166Dihydropteroate synthase
Frateuria aurantia3245Fraau_1996dihydropteroate synthase
Fusobacterium nucleatum subsp. NucleatumFN0073Dihydropteroate synthase
Gemmata obscuriglobusGEMOB_RS37505dihydropteroate synthase
Geodermatophilus obscurus13315Gobs_0295dihydropteroate synthase
Gobs_0618dihydropteroate synthase
Gobs_2876dihydropteroate synthase
Gobs_2900dihydropteroate synthase
Gloeobacter violaceusglr0540dihydropteroate synthase
Gluconacetobacter hansenii14816GXY_16127dihydropteroate synthase
Gluconobacter frateurii101659GfraN1_010100000375dihydropteroate synthase
Gordonia aichiensis108223GOACH_01_01730dihydropteroate synthase
GOACH_03_06090putative dihydropteroate synthase
Gordonia alkanivorans16433GOALK_015_00220dihydropteroate synthase
GOALK_072_01490putative dihydropteroate synthase
Gordonia amarae15530GOAMR_69_00530putative dihydropteroate synthase
GOAMR_72_00220dihydropteroate synthase
Gordonia amicalis100051GOAMI_15_01480putative dihydropteroate synthase
GOAMI_36_00180dihydropteroate synthase
Gordonia araii100433GOARA_053_00160dihydropteroate synthase
GOARA_061_00640putative dihydropteroate synthase
Gordonia bronchialis16047Gbro_3311dihydropteroate synthase
Gbro_4015dihydropteroate synthase
Gordonia effusa100432GOEFS_076_00330dihydropteroate synthase
GOEFS_132_00960putative dihydropteroate synthase
Gordonia hirsuta16056GOHSU_04_00900putative dihydropteroate synthase
GOHSU_61_00120dihydropteroate synthase
Gordonia namibiensis108229GONAM_09_00070putative dihydropteroate synthase
GONAM_34_00260dihydropteroate synthase
Gordonia otitidis100426GOOTI_012_00240dihydropteroate synthase
GOOTI_115_00120putative dihydropteroate synthase
Gordonia polyisoprenivorans16320GOPIP_004_00490putative dihydropteroate synthase
GOPIP_077_01400dihydropteroate synthase
Gordonia rhizosphera16068GORHZ_058_00130dihydropteroate synthase
GORHZ_123_00200putative dihydropteroate synthase
GORHZ_200_00250dihydropteroate synthase
Gordonia rubripertincta101908GORBP_059_00520dihydropteroate synthase
GORBP_065_01680putative dihydropteroate synthase
Gordonia sihwensis108236GSI01S_10_00690putative dihydropteroate synthase
GSI01S_12_00110dihydropteroate synthase
Gordonia soli108243GS4_02_01350putative dihydropteroate synthase
GS4_11_04010dihydropteroate synthase
Gordonia sputi100414GOSPT_098_00050putative dihydropteroate synthase
GOSPT_103_00590dihydropteroate synthase
Gordonia terrae100016GOTRE_018_00230putative dihydropteroate synthase
GOTRE_054_00600dihydropteroate synthase
Haloarcula vallismortis14741C437_07682dihydropteroate synthase
C437_09508dihydropteroate synthase
Halobacillus halophilus102448HBHAL_1091dihydropteroate synthase
Halobacterium sp.VNG_0412Gdihydropteroate synthase
Halomonas elongata15536HELO_4143dihydropteroate synthase
Herpetosiphon aurantiacusHaur_3166dihydropteroate synthase
Holophaga foetidaHOLFODRAFT_RS21815hypothetical protein
Hylemonella gracilis14920HGR_12717dihydropteroate synthase
Hyphomonas neptunium14232HNE_2366dihydropteroate synthase
Ignavibacterium album101810IALB_1594Dihydropteroate synthase
Intrasporangium calvum12989Intca_0305Dihydropteroate synthase
Intca_0602Dihydropteroate synthase
Jonesia denitrificans15587Jden_0807dihydropteroate synthase
Jden_2102dihydropteroate synthase
Kineococcus radiotolerans101839Krad_0540dihydropteroate synthase
Kineosphaera limosa100340KILIM_069_00240dihydropteroate synthase
KILIM_093_00050dihydropteroate synthase
Kitasatospora setae14216KSE_43860putative dihydropteroate synthase
KSE_48480putative dihydropteroate synthase
Klebsiella pneumoniae14438KPR_4780
Klebsiella pneumoniae subsp. rhinoscleromatis105682HMPREF0484_2908dihydropteroate synthase
Kocuria rhizophila103217KRH_19260dihydropteroate synthase
Kordia algicida100336KAOT1_10516dihydropteroate synthase
Kribbella flavida14399Kfla_5172dihydropteroate synthase
Kfla_6465dihydropteroate synthase
Ktedonobacter racemiferKrac_7666dihydropteroate synthase
Kyrpidia tusciae15312Btus_0103dihydropteroate synthase
Kytococcus sedentarius15357Ksed_24760Dihydropteroate synthase
Labrenzia aggregata16684SIAM614_25387dihydropteroate synthase
Lactobacillus delbrueckii subsp. bulgaricus13953Ldb0249Dihydropteroate synthase
Lactobacillus fermentum15885HMPREF0511_1714dihydropteroate synthase
Lactobacillus fermentum3956LAF_1336dihydropteroate synthase
Lactobacillus helveticus15019HMPREF0518_0255dihydropteroate synthase
Lactobacillus hilgardii15886HMPREF0519_2230dihydropteroate synthase
Lactobacillus plantarum subsp. plantarum15891HMPREF0531_12975dihydropteroate synthase
Lactobacillus reuteri15892LAR_1208dihydropteroate synthase
Leadbetterella byssophila106382Lbys_1609Dihydropteroate synthase
Lentisphaera araneosaLNTAR_09074dihydropteroate pyrophosphorylase
Leptospira interrogansLA_0057dihydropteroate synthase
Limnochorda pilosa110152LIP_0132hypothetical protein
LIP_3124dihydropteroate synthase
Magnetospirillum gryphiswaldense15271MGR_1803Dihydropteroate synthase
Magnetospirillum magnetotacticum15272Magn03004888COG0294: Dihydropteroate synthase and related enzymes
Magn03010011COG0294: Dihydropteroate synthase and related enzymes
Marinomonas mediterranea103028Marme_0973dihydropteroate synthase
Mariprofundus ferrooxydansSPV1_11386dihydropteroate synthase
Marivirga tractuosa15989Ftrac_3719Dihydropteroate synthase
Meiothermus silvanus106475Mesil_0310dihydropteroate synthase
Methylacidiphilum infernorumMinf_1898Dihydropteroate synthase
Methylobacterium radiotolerans15690Mrad2831_0513dihydropteroate synthase
Micrococcus luteus3333Mlut_01260Dihydropteroate synthase
Mlut_14860Dihydropteroate synthase
Microlunatus phosphovorus101784MLP_32710putative dihydropteroate synthase
MLP_48450dihydropteroate synthase
Micromonospora aurantiaca16155Micau_0655dihydropteroate synthase
Micau_1778dihydropteroate synthase
Micau_5873dihydropteroate synthase
Microscilla marina16560M23134_07025dihydropteroate synthase
Mobilicoccus pelagius104925MOPEL_074_00720dihydropteroate synthase
Myroides odoratus14945Myrod_2703dihydropteroate synthase
Nakamurella multipartita105858Namu_0850dihydropteroate synthase
Namu_2145dihydropteroate synthase
Niastella koreensis106392Niako_2018dihydropteroate synthase
Nitriliruptor alkaliphilusNitalDRAFT_0122dihydropteroate synthase
NitalDRAFT_1536dihydropteroate synthase
Nitrosomonas europaea14298NE0529Dihydropteroate synthase
Nitrospina gracilisNITGR_700027Dihydropteroate synthase
Nocardiopsis dassonvillei14626Ndas_1234dihydropteroate synthase
Ndas_4972dihydropteroate synthase
Nostoc sp.alr4386dihydropteroate synthase
Oceanithermus profundus100410Ocepr_1870Dihydropteroate synthase
Ochrobactrum anthropi15819Oant_2115dihydropteroate synthase
Ochrobactrum intermedium15820OINT_1001191dihydropteroate synthase
Paenibacillus alvei3343PAV_2c06580dihydropteroate synthase Sul
Paenibacillus peoriae15541PpeoK3_010100024094dihydropteroate synthase (dihydropteroate pyrophosphorylase)
Paenibacillus polymyxa15309PPT_00375dihydropteroate synthase
Pedobacter heparinus12017Phep_3663dihydropteroate synthase
Pedobacter saltans100064Pedsa_3680Dihydropteroate synthase
Pelobacter carbinolicus103641Pcar_0998dihydropteroate synthase
Pelobacter propionicus103807Ppro_2253Dihydropteroate synthase
Phaeobacter gallaeciensis16654PGA1_c06540dihydropteroate synthase FolP
Photobacterium damselae subsp. damselae corrig.15633VDA_002837dihydropteroate synthase
Phycisphaera mikurensis102666PSMK_03290dihydropteroate synthase
Picrophilus torridus100828PTO0551dihydropteroate synthase
Planctomyces brasiliensis103401Plabr_0523Dihydropteroate synthase
Prochlorococcus marinus subsp. marinusPro_0902Dihydropteroate synthase and related enzymes
Propionibacterium acidipropionici12425PACID_08730Dihydropteroate synthase ((2-amino-4-hydroxy-7, 8-dihydropteridin-6-yl)methyl-diphosphate:4- aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase)
PACID_28470Dihydropteroate synthase
Propionibacterium avidum15671HMPREF9153_1336dihydropteroate synthase
Proteus mirabilis105697HMPREF0693_2341dihydropteroate synthase
Providencia alcalifaciens105687PROVALCAL_01054dihydropteroate synthase
Pseudomonas putida100650PP_4717dihydropteroate synthase
Pseudomonas stutzeri14165PSTAB_3363dihydropteroate synthase
Rahnella aquatilis105701Rahaq2_0507dihydropteroate synthase
Renibacterium salmoninarum15589RSal33209_3213dihydropteroate synthase
Rhizobium etli15573RHE_CH02336dihydropteroate synthase protein
Rhizobium sp.101917NGR_c16600dihydropteroate synthase
Rhizobium tropici15247RTCIAT899_CH10005dihydropteroate synthase
Rhodobacter capsulatus16581RCAP_rcc01211dihydropteroate synthase
Rhodobacter sphaeroides12203RSP_1862Dihydropteroate synthase
Rhodococcus erythropolis100887RER_06270dihydropteroate synthase
RER_41670putative dihydropteroate synthase
Rhodococcus opacus108011ROP_15020dihydropteroate synthase
ROP_43250dihydropteroate synthase
ROP_60280putative dihydropteroate synthase
Roseobacter denitrificans15277RD1_1951dihydropteroate synthase
Roseobacter litoralis15278RLO149_c010460dihydropteroate synthase (DHPS)
Rothia dentocariosa12531HMPREF0733_10714dihydropteroate synthase
Rothia mucilaginosa15673ROTMU0001_1805dihydropteroate synthase
Rubrobacter xylanophilus100952Rxyl_2184Dihydropteroate synthase
Saccharomonospora azurea14651SacazDRAFT_02326dihydropteroate synthase
SacazDRAFT_04013dihydropteroate synthase
Saccharomonospora cyanea14841SaccyDRAFT_1351dihydropteroate synthase
SaccyDRAFT_4695dihydropteroate synthase
Saccharomonospora glauca14831SacglDRAFT_01265dihydropteroate synthase
SacglDRAFT_03953dihydropteroate synthase
Saccharomonospora viridis12207Svir_11500Dihydropteroate synthase
Svir_11700dihydropteroate synthase
Svir_35630Dihydropteroate synthase
Saccharopolyspora erythraea13426SACE_03987,8-dihydropteroate synthase (partial match)
SACE_1023dihydropteroate synthase
SACE_4499dihydropteroate synthase
Saccharopolyspora spinosa15153SspiN1_010100007180dihydropteroate synthase
SspiN1_010100010289dihydropteroate synthase
SspiN1_0101000211237,8-dihydropteroate synthase (partial match)
SspiN1_010100023887dihydropteroate synthase
Saccharothrix espanaensis15066BN6_03520Dihydropteroate synthase 1
BN6_08630Inactive dihydropteroate synthase 2
Salinibacter ruberSRU_1947dihydropteroate synthase
Salinispora tropica105044Strop_0702Dihydropteroate synthase
Strop_4297dihydropteroate synthase
Sanguibacter keddieii16158Sked_25940Dihydropteroate synthase
Sked_32070Dihydropteroate synthase
Selenomonas ruminantium subsp. lactilytica103574SELR_27270putative dihydropteroate synthase
Serratia odorifera102598HMPREF0758_0809dihydropteroate synthase
Shimwellia blattae105725EB105725_14_00960dihydropteroate synthase
Solitalea canadensis15130Solca_4429dihydropteroate synthase
Sphingobacterium spiritivorum14948HMPREF0766_10242dihydropteroate synthase
Sphingobium japonicum101211SJA_C1-27270dihydropteroate synthase
Sphingobium sp.103272SLG_20910dihydropteroate synthase
Sphingomonas echinoides15742SechA1_010100012512dihydropteroate synthase
Sphingomonas wittichii105917Swit_4577Dihydropteroate synthase
Sporichthya polymorpha12702Spopo_30_19730Dihydropteroate synthase
Spopo_31_05310Inactive dihydropteroate synthase 2
Stackebrandtia nassauensis102104Snas_6218dihydropteroate synthase
Staphylococcus epidermidis12993SE_2269dihydropteroate synthase chain A synthetase
Staphylococcus saprophyticus subsp. saprophyticus102446SSP2242dihydropteroate synthase
Starkeya novella14993Snov_0656dihydropteroate synthase
Streptococcus equinus12553HMPREF0819_0601dihydropteroate synthase
Streptococcus mitis106071SM12261_0582dihydropteroate synthase
Streptomyces avermitilis14893SAV3123putative dihydropteroate synthase
SAV4672putative dihydropteroate synthase
Streptomyces cattleya14057SCAT_2649dihydropteroate synthase
SCAT_3998Dihydropteroate synthase 2
Streptomyces clavuligerus13307SCLAV_2407Dihydropteroate synthase
SCLAV_3999Dihydropteroate synthase
Streptomyces ghanaensis15414SSFG_02541dihydropteroate synthase
SSFG_03186dihydropteroate synthase
Streptomyces mobaraensis13819H340_05534dihydropteroate synthase
H340_23433dihydropteroate synthase
Streptomyces pristinaespiralis13074SSDG_01879dihydropteroate synthase
SSDG_04933dihydropteroate synthase
Streptomyces purpureus13925STRPU_11_01790Dihydropteroate synthase
STRPU_13_03930Dihydropteroate synthase
Streptomyces sviceus13980SSEG_04236dihydropteroate synthase
SSEG_09480dihydropteroate synthase
Streptomyces venezuelae13096SVEN_3250Dihydropteroate synthase
SVEN_4787Non functional Dihydropteroate synthase 2
SVEN_5577Dihydropteroate synthase
Streptosporangium roseum3776Sros_3417Dihydropteroate synthase
Sros_9173Dihydropteroate synthase
Synechococcus elongatusSynpcc7942_2303Dihydropteroate synthase
Synechocystis sp.slr2026gene:folP or dhpS
Thauera linaloolentis102519C666_03315dihydropteroate synthase
Thermanaerovibrio acidaminovoransTaci_0619dihydropteroate synthase
Thermobispora bispora14880Tbis_1874dihydropteroate synthase
Tbis_3445dihydropteroate synthase
Thermococcus sp.GQS_03295dihydropteroate synthase
Thermodesulfobacterium communeHL41_02750dihydropteroate synthase
Thermodesulfobium narugense100082Thena_1770dihydropteroate synthase
Thermodesulfovibrio yellowstoniiTHEYE_A0627dihydropteroate synthase
Thermomicrobium roseumtrd_1325dihydropteroate synthase
Thermomonospora curvata15933Tcur_2621dihydropteroate synthase
Tcur_4503dihydropteroate synthase
Thermotoga lettingae107922Tlet_0902dihydropteroate synthase
Thermotoga maritima100826TM_0040dihydropteroate synthase
Thermotoga naphthophila104846Tnap_0671dihydropteroate synthase
Thermotoga neapolitana107923CTN_0651Dihydropteroate synthase
Thermotoga petrophila104847Tpet_0883Dihydropteroate synthase
Thermotoga thermarum107925Theth_0255dihydropteroate synthase
Thermus thermophilus101084TTHA0191dihydropteroate synthase
Thermus thermophilus101085TT_C1795dihydropteroate synthase
Tsukamurella paurometabola16120Tpau_0561dihydropteroate synthase
Tpau_1164dihydropteroate synthase
Turicella otitidis106139HMPREF9719_01344dihydropteroate synthase
Vibrio alginolyticus15630N646_1557dihydropteroate synthase
Vibrio ichthyoenteri15847VII00023_04068dihydropteroate synthase
Vibrio metschnikovii103153VIB_000257dihydropteroate synthase
Vibrio orientalis15638VIOR3934_00975dihydropteroate synthase
Vibrio tubiashii15644VITU9109_06924dihydropteroate synthase
VITU9109_26230dihydropteroate synthase
Vibrio vulnificus15645B736_01580dihydropteroate synthase
Weeksella virosa16016Weevi_1503dihydropteroate synthase
Xenococcus sp.Xen7305DRAFT_00029050dihydropteroate synthase
Xylanimonas cellulosilytica107835Xcel_0978dihydropteroate synthase
Xcel_2985dihydropteroate synthase
Yersinia bercovieri105717yberc0001_8640Dihydropteroate synthase
Yersinia rohdei105715yrohd0001_7020Dihydropteroate synthase
Zimmermannella faecalis15706G328_13140hypothetical protein
Zymomonas mobilis subsp. pomaceae13757Zymop_0272dihydropteroate synthase